Models Directory
Researchers with the Centre for Predictive in vitro Models are actively developing and using a wide range of in vitro models including organ-on-a-chip, organoids and other forms of microphysiological systems, spanning the following clinical specialties:
Cardiology • Dermatology • Endocrinology & Diabetes • Gastroenterology • Haematology • Infectious Diseases • Nephrology • Neurology • Oncology • Respiratory Medicine • Rheumatology
Unless indicated, further details on all models listed below are available in peer-reviewed publications (*pre-print only). Models in additional areas are under development and will be added as they become available.
| Category | Model | Context of Use |
|---|---|---|
| Endocrinology & Diabetes | Adipose Niches | Ovarian cancer cell migration to the omentum, adipose bone marrow |
| Oncology | Breast Cancer Bone Metastasis | Osteolytic bone metastasis in breast cancer |
| Cardiology | Cardiac Organoid | Cardiomyocyte electrophysiology |
| Neurology | Cerebellar Organoid | Cerebellum development and cancer |
| Cardiology | Coronary Artery | Arterial inflammation, cardiovascular disease, atherosclerosis |
| Oncology | Early Breast Cancer |
Progression from ductal carcinoma in situ to invasive ductal carcinoma
|
| Dermatology | Full Thickness Skin | Epidermal barrier homeostasis, lipid deficiency and barrier damage, ichthyoses |
| Oncology | Glioma Outgrowth | Interactions between healthy and cancerous brain tissue |
| Rheumatology | Growth Plate | Osteochondral development |
| Oncology | Head and Neck Cancer | Head and neck squamous cell carcinoma drug screening |
| Gastroenterology | Intestine* | Inflammatory bowel disease, Crohn’s disease, ulcerative colitis |
| Gastroenterology | Liver Fibrosis | Endothelial-to-mesenchymal transition |
| Cardiology | Microvascularised Tissue-on-Chip | 3D hydrogel models with perfused microvascular networks |
| Neurology | Neuromuscular Junction | Neuromuscular disease, drug toxicity, ageing |
| Oncology | Ovarian Cancer Niche | High-grade serous ovarian cancer microenvironment |
| Oncology | Ovarian Tumour Slices | Ovarian cancer immune microenvironments |
| Cardiology | Perfused Blood Vessels | Endothelial cells under flow |
| Dermatology | Skin Inflammation | Immune-cell trafficking and skin ageing |
| Dermatology | Skin Senescence | Skin senescence and ageing |
| Rheumatology | Tendon & Tendinopathy* | Tendinopathy and cellular crosstalk |
| Cardiology | Vascular Organoid | Vascular inflammation, atherosclerosis, angiogenesis |
| Oncology | Vascularised Ovarian Cancer | Omental metastasis and CAR‑T cell therapy |
| Rheumatology | Vascularised Synovium | Synovial inflammation, synovitis, arthritis |