A World-Leading Centre for Predictive in vitro Model Research, Training and Translation
The Queen Mary, Centre for Predictive in vitro Models (CPM) provides a beacon of multidisciplinary research, training, and translation focusing on the development and use of predictive in vitro models. This incorporates a wide range of model systems including 2D and 3D cell culture models, organoids, microphysiological systems, organ-on-a-chip technology, Non Animal Methods (NAMs), and other types of in vitro model.
With approximately 70 academic staff across the Faculty of Science and Engineering and the Faculty of Medicine and Dentistry, Queen Mary's Centre for Predictive in vitro Models is leading development and use of these complex in vitro models in partnership the regulatory authorities, pharmaceuticals and healthcare industry, companies developing the technology platforms, and other stake holders.
Queen Mary led the UK Organ-on-a-Chip Technologies Network funded by UKRI (2018-2022) with over 1,000 members from 60+ universities and multiple stake holder partners, successfully establishing the organ-chip community in the UK. Queen Mary continues to provide leadership in this field hosting the annual UK symposium and engaging with Government, policy makers, funders, industry and other stake holders to support development and adoption of this transformative technology.
Events
| Tue 11 - Thu 13 Feb 2025 | World Organoid & Organ-Chip Research Day (WORD+) 2025 |
 Thu 20 Feb 2025 | CPM Affiliates Club Meeting & Showcase |
| Mon 9 - Fri 13 Jun 2025 | Microphysiological Systems (MPS) World Summit 2025 |
| Wed 18 - Fri 20 Jun 2025 | Tissue & Cell Engineering Society Conference 2025 |
Recent Publications
- Air Pollution and Osteoporosis
Allen O, Knight MM and Verbruggen SW
Current Osteoporosis Reports, Springer Science and Business Media Llc
20-09-2024 - Guidelines for minimal information on cellular senescence experimentation in vivo
Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T and Yun MH
Cell, Elsevier vol. 187 (16), 4150-4175.
01-08-2024 - Human 3D Ovarian Cancer Models Reveal Malignant Cell-Intrinsic and -Extrinsic Factors That Influence CAR T-cell Activity.
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Manchanda R, Annibaldi A, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill FR
Cancer Res vol. 84 (15), 2432-2449.
01-08-2024
Recent Grants
- Organ-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacement
Hazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in ResearchGrant Summary
07-10-2024 - 14-03-2025 - Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicines
Martin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research CouncilGrant Summary
01-10-2024 - 30-09-2027 - The role of novel mechanosensitive complex in cardiomyocyte pathophysiology
Thomas Iskratsch and Andrew Tinker
£254,588 BHF British Heart Foundation
01-10-2024 - 30-09-2027
