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Research Grants

Current funding of Predictive in vitro Model research:
£6,261,909

Staff within the Centre for Predictive in vitro Models (CPM) currently hold a large portfolio of grants directly related to the development and use of predictive in vitro models.

The following are current funded research projects led by members of the CPM:

Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease
Knight MM and Bishop C
Engineering and Physical Sciences Research Council (06-09-2021 - 03-03-2025)
Summary
Reprogramming Resolution in the Arthritic Joint
Norling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)
Identifying and manipulating molecular mechanisms controlling cancer stem cell metastatic potential in a human oral cancer model.
Biddle AJ and Wang J
£679,533 Medical Research Council (02-08-2021 - 01-08-2024)
The regulation of mechanosensing in healthy and atherosclerotic vascular smooth muscle cells
Swiatlowska P and Iskratsch T
£238,020 British Heart Foundation (01-12-2020 - 30-11-2023)
PhD studentship: Biophysical effects of Physiogel on human skin equivalents
Connelly JT
£116,000 Biotechnology and Biological Sciences Research Council (01-10-2019 - 01-10-2023)
Queen Mary+Emulate Organs-on-chips Centre
Screen HRC and Knight MM
£525,375 Emulate Inc and QMUL (20-09-2019 - 19-09-2023)
Summary
MICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Screen HRC, Knight MM and El Haj A
£504,557 Medical Research Council (24-08-2020 - 23-08-2023)
Summary
Organ-on-a-chip model of breast cancer bone metastases
Knight MM
£269,601 Cancer Research UK (04-01-2021 - 01-07-2023)
Summary
PhD studentship: Development of an immune-responsive human skin model
Connelly JT
Medical Research Council (01-10-2019 - 01-03-2023)
3D Photoelectrochemical imaging in porous light-addressable structures
Krause SK and Zhou B
£202,249 Engineering and Physical Sciences Research Council (01-02-2021 - 31-10-2022)
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
Biddle AJ, Scemama A and Gautrot JEE
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-09-2022)
Expert technical support for CREATE Lab pump-priming projects
Connelly JT
£240,000 Barts Charity (01-10-2018 - 30-09-2022)
Investigation of synovium-cartilage pro-inflammatory cross talk and the role of primary cilia using organ-chip models
Knight MM and Terrazas D
Conacyt Scholarship (16-09-2019 - 15-09-2022)
Combined LAPS and SICM for multimodal live cell imaging
Krause SK and Das A
£571,838 Engineering and Physical Sciences Research Council (01-09-2018 - 31-08-2022)
Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopillars
Iskratsch T
£490,544 Biotechnology and Biological Sciences Research Council (01-02-2019 - 31-01-2022)
Summary
The Animal Replacement Centre of Excellence
Biddle AJ and Youssef G
£1,000,000 Animal Free Research UK (01-08-2016 - 31-07-2021)
Organ-on-a-chip Technologies
Screen HRC, Bull AMJ, Haj AJE, Knight MM, Carr AJ, Gunn JPG, Dalby MJ and Workman P
£479,338 Medical Research Council (31-07-2018 - 30-07-2021)
Summary
Understanding the mechnobiology of senescence and ageing
Connelly JT
£134,000 Dunhill Medical Trust (15-04-2019 - 14-06-2021)


Multiscale nuclear mechanobiology within the skin: from biophysical cues to epigenetic effects
Connelly JT and Gavara N
£469,683 Biotechnology and Biological Sciences Research Council (01-05-2017 - 30-04-2020)
Summary
Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degeneration
Krause SK and Das A
£146,591 Horizon 2020 (01-07-2017 - 30-06-2019)
Towards in-vivo electrochemical imaging with flexible, light-addressable electrodes
Krause SK and Fenwick OJ
£15,000 Royal Society (15-03-2018 - 14-03-2019)
Super-resolution Light-Addressable Potentiometric Sensors (LAPS)
Krause SK and Zhang D
£147,661 Biotechnology and Biological Sciences Research Council (20-07-2017 - 19-07-2018)
The role of high frequency loading in the treatment of tendinopathy.
Screen HRC
Orthopaedic Research UK (01-10-2012 - 30-09-2015)
Human tenocyte metabolism under physiological and pathological loading conditions
Screen H
£100,761 Versus Arthritis (03-10-2011 - 02-10-2014)
Summary
Role of JAM-C in inflammatory and vascular events in vivo as studied using an experimental model of ovarian cancer.
Nourshargh S and Balkwill FR
£227,807 Wellcome Trust (01-01-2010 - 31-12-2012)
Summary