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Research Grants

Current funding of Predictive in vitro Model research:
£6,451,909

Staff within the Centre for Predictive in vitro Models (CPM) currently hold a large portfolio of grants directly related to the development and use of predictive in vitro models.

The following are examples of current funded research projects, specifically related to predictive in vitro models and led by members of the CPM

Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease
Knight MM and Bishop C
Engineering and Physical Sciences Research Council (06-09-2021 - 03-03-2025)
Summary
Reprogramming Resolution in the Arthritic Joint
Norling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)
Identifying and manipulating molecular mechanisms controlling cancer stem cell metastatic potential in a human oral cancer model.
Biddle AJ and Wang J
£679,533 Medical Research Council (02-08-2021 - 01-08-2024)
The regulation of mechanosensing in healthy and atherosclerotic vascular smooth muscle cells
Swiatlowska P and Iskratsch T
£238,020 British Heart Foundation (01-12-2020 - 30-11-2023)
3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling and drug discovery
Lin Y-Y
£90,000 National Centre for the Replacement Refinement and Reduction of Animals in Research (01-11-2020 - 31-10-2023)
Summary
PhD studentship: Biophysical effects of Physiogel on human skin equivalents
Connelly JT
£116,000 Biotechnology and Biological Sciences Research Council (01-10-2019 - 01-10-2023)
Queen Mary+Emulate Organs-on-chips Centre
Screen HRC and Knight MM
£525,375 Emulate Inc and QMUL (20-09-2019 - 19-09-2023)
Summary
MICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Screen HRC, Knight MM and El Haj A
£504,557 Medical Research Council (24-08-2020 - 23-08-2023)
Summary
Organ-on-a-chip model of breast cancer bone metastases
Knight MM
£269,601 Cancer Research UK (04-01-2021 - 01-07-2023)
Summary
PhD studentship: Development of an immune-responsive human skin model
Connelly JT
Medical Research Council (01-10-2019 - 01-03-2023)
3D Photoelectrochemical imaging in porous light-addressable structures
Krause SK and Zhou B
£202,249 Engineering and Physical Sciences Research Council (01-02-2021 - 31-10-2022)
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
Biddle AJ, Scemama A and Gautrot JEE
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-09-2022)
Expert technical support for CREATE Lab pump-priming projects
Connelly JT
£240,000 Barts Charity (01-10-2018 - 30-09-2022)
Investigation of synovium-cartilage pro-inflammatory cross talk and the role of primary cilia using organ-chip models
Knight MM and Terrazas D
Conacyt Scholarship (16-09-2019 - 15-09-2022)
Combined LAPS and SICM for multimodal live cell imaging
Krause SK and Das A
£571,838 Engineering and Physical Sciences Research Council (01-09-2018 - 31-08-2022)
Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopillars
Iskratsch T
£490,544 Biotechnology and Biological Sciences Research Council (01-02-2019 - 31-01-2022)
Summary
Engineering a human microphysiological platform for modelling soft tissue injury and regeneration
Lin Y-Y
£100,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (04-01-2021 - 11-08-2021)
The Animal Replacement Centre of Excellence
Philpott MP, Biddle AJ and Youssef G
£1,000,000 Animal Free Research UK (01-08-2016 - 31-07-2021)
Organ-on-a-chip Technologies
Screen HRC, Bull AMJ, Haj AJE, Knight MM, Carr AJ, Gunn JPG, Dalby MJ and Workman P
£479,338 Medical Research Council (31-07-2018 - 30-07-2021)
Summary


Understanding the mechnobiology of senescence and ageing
Connelly JT
£134,000 Dunhill Medical Trust (15-04-2019 - 14-06-2021)
CRISPR/Cas9 Engineered Human IPSC Models for Muscular Dystrophy
Lin Y-Y
£490,000 Pfizer (13-11-2017 - 31-03-2021)
A microphysiological human 3D neuromuscular platform for modelling DMD and assessing potential therapeutics
Lin Y-Y
EUR25,000 Duchenne Parent Project (01-02-2020 - 01-02-2021)
Multiscale nuclear mechanobiology within the skin: from biophysical cues to epigenetic effects
Connelly JT and Gavara N
£469,683 Biotechnology and Biological Sciences Research Council (01-05-2017 - 30-04-2020)
Summary
Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degeneration
Krause SK and Das A
£146,591 Horizon 2020 (01-07-2017 - 30-06-2019)
Towards in-vivo electrochemical imaging with flexible, light-addressable electrodes
Krause SK and Fenwick OJ
£15,000 Royal Society (15-03-2018 - 14-03-2019)
Super-resolution Light-Addressable Potentiometric Sensors (LAPS)
Krause SK and Zhang D
£147,661 Biotechnology and Biological Sciences Research Council (20-07-2017 - 19-07-2018)
The role of high frequency loading in the treatment of tendinopathy.
Screen HRC
Orthopaedic Research UK (01-10-2012 - 30-09-2015)
Human tenocyte metabolism under physiological and pathological loading conditions
Screen H
£100,761 Versus Arthritis (03-10-2011 - 02-10-2014)
Summary
Role of JAM-C in inflammatory and vascular events in vivo as studied using an experimental model of ovarian cancer.
Nourshargh S and Balkwill FR
£227,807 Wellcome Trust (01-01-2010 - 31-12-2012)
Summary