Research Grants
Current funding of Predictive in vitro Model research:
£6,451,909
£6,451,909
Staff within the Centre for Predictive in vitro Models (CPM) currently hold a large portfolio of grants directly related to the development and use of predictive in vitro models.
The following are examples of current funded research projects, specifically related to predictive in vitro models and led by members of the CPM
Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney DiseaseKnight MM and Bishop C
Engineering and Physical Sciences Research Council (06-09-2021 - 03-03-2025)
Reprogramming Resolution in the Arthritic JointNorling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)
Identifying and manipulating molecular mechanisms controlling cancer stem cell metastatic potential in a human oral cancer model.Biddle AJ and Wang J
£679,533 Medical Research Council (02-08-2021 - 01-08-2024)
The regulation of mechanosensing in healthy and atherosclerotic vascular smooth muscle cellsSwiatlowska P and Iskratsch T
£238,020 British Heart Foundation (01-12-2020 - 30-11-2023)
3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling and drug discoveryLin Y-Y
£90,000 National Centre for the Replacement Refinement and Reduction of Animals in Research (01-11-2020 - 31-10-2023)
PhD studentship: Biophysical effects of Physiogel on human skin equivalentsConnelly JT
£116,000 Biotechnology and Biological Sciences Research Council (01-10-2019 - 01-10-2023)
Queen Mary+Emulate Organs-on-chips CentreScreen HRC and Knight MM
£525,375 Emulate Inc and QMUL (20-09-2019 - 19-09-2023)
MICA: Organ-on-a-chip models for safety testing of regenerative medicine productsScreen HRC, Knight MM and El Haj A
£504,557 Medical Research Council (24-08-2020 - 23-08-2023)
Organ-on-a-chip model of breast cancer bone metastasesKnight MM
£269,601 Cancer Research UK (04-01-2021 - 01-07-2023)
PhD studentship: Development of an immune-responsive human skin modelConnelly JT
Medical Research Council (01-10-2019 - 01-03-2023)
3D Photoelectrochemical imaging in porous light-addressable structuresKrause SK and Zhou B
£202,249 Engineering and Physical Sciences Research Council (01-02-2021 - 31-10-2022)
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic modelBiddle AJ, Scemama A and Gautrot JEE
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-09-2022)
Expert technical support for CREATE Lab pump-priming projectsConnelly JT
£240,000 Barts Charity (01-10-2018 - 30-09-2022)
Investigation of synovium-cartilage pro-inflammatory cross talk and the role of primary cilia using organ-chip modelsKnight MM and Terrazas D
Conacyt Scholarship (16-09-2019 - 15-09-2022)
Combined LAPS and SICM for multimodal live cell imagingKrause SK and Das A
£571,838 Engineering and Physical Sciences Research Council (01-09-2018 - 31-08-2022)
Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopillarsIskratsch T
£490,544 Biotechnology and Biological Sciences Research Council (01-02-2019 - 31-01-2022)
Engineering a human microphysiological platform for modelling soft tissue injury and regenerationLin Y-Y
£100,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (04-01-2021 - 11-08-2021)
The Animal Replacement Centre of ExcellencePhilpott MP, Biddle AJ and Youssef G
£1,000,000 Animal Free Research UK (01-08-2016 - 31-07-2021)
Organ-on-a-chip TechnologiesScreen HRC, Bull AMJ, Haj AJE, Knight MM, Carr AJ, Gunn JPG, Dalby MJ and Workman P
£479,338 Medical Research Council (31-07-2018 - 30-07-2021)
Understanding the mechnobiology of senescence and ageingConnelly JT
£134,000 Dunhill Medical Trust (15-04-2019 - 14-06-2021)
CRISPR/Cas9 Engineered Human IPSC Models for Muscular DystrophyLin Y-Y
£490,000 Pfizer (13-11-2017 - 31-03-2021)
A microphysiological human 3D neuromuscular platform for modelling DMD and assessing potential therapeuticsLin Y-Y
EUR25,000 Duchenne Parent Project (01-02-2020 - 01-02-2021)
Multiscale nuclear mechanobiology within the skin: from biophysical cues to epigenetic effectsConnelly JT and Gavara N
£469,683 Biotechnology and Biological Sciences Research Council (01-05-2017 - 30-04-2020)
Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degenerationKrause SK and Das A
£146,591 Horizon 2020 (01-07-2017 - 30-06-2019)
Towards in-vivo electrochemical imaging with flexible, light-addressable electrodesKrause SK and Fenwick OJ
£15,000 Royal Society (15-03-2018 - 14-03-2019)
Super-resolution Light-Addressable Potentiometric Sensors (LAPS)Krause SK and Zhang D
£147,661 Biotechnology and Biological Sciences Research Council (20-07-2017 - 19-07-2018)
The role of high frequency loading in the treatment of tendinopathy.Screen HRC
Orthopaedic Research UK (01-10-2012 - 30-09-2015)
Human tenocyte metabolism under physiological and pathological loading conditionsScreen H
£100,761 Versus Arthritis (03-10-2011 - 02-10-2014)
Role of JAM-C in inflammatory and vascular events in vivo as studied using an experimental model of ovarian cancer.Nourshargh S and Balkwill FR
£227,807 Wellcome Trust (01-01-2010 - 31-12-2012)