Research Grants

Staff within the Centre for Predictive in vitro Models (CPM) currently hold a large portfolio of grants directly related to the development and use of predictive in vitro models.

The following are examples of current funded research projects, specifically related to predictive in vitro models and led by members of the CPM

PhD Studentship: Development of an arterial organ-chip to study the role of primary cilia in atherosclerosis
Knight MM and Screen H
China Scholarship Council (06-09-2021 - 08-09-2025)

Summary

PhD Studentship: Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease
Knight MM and Bishop C
Engineering and Physical Sciences Research Council (06-09-2021 - 03-03-2025)

Summary

Reprogramming Resolution in the Arthritic Joint
Norling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)

Identifying and manipulating molecular mechanisms controlling cancer stem cell metastatic potential in a human oral cancer model.
Biddle AJ and Wang J
£679,533 Medical Research Council (02-08-2021 - 01-08-2024)

EC Jetting: Towards the Next Generation of Printing Technologies
Ismail ASM
£296,834 Engineering and Physical Sciences Research Council (01-04-2022 - 31-03-2024)

Summary

The regulation of mechanosensing in healthy and atherosclerotic vascular smooth muscle cells
Swiatlowska P and Iskratsch T
£238,020 British Heart Foundation (01-12-2020 - 30-11-2023)

3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling and drug discovery
Lin Y-Y and Moreno Sierra N
National Centre for the Replacement Refinement and Reduction of Animals in Research (09-11-2020 - 08-11-2023)

Summary

3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling and drug discovery
Lin Y-Y
£90,000 National Centre for the Replacement Refinement and Reduction of Animals in Research (01-11-2020 - 31-10-2023)

Summary

PhD studentship: Biophysical effects of Physiogel on human skin equivalents
Connelly JT
£116,000 Biotechnology and Biological Sciences Research Council (01-10-2019 - 01-10-2023)

Queen Mary+Emulate Organs-on-chips Centre
Screen HRC and Knight MM
£525,375 Emulate Inc and QMUL (20-09-2019 - 19-09-2023)

Summary

MICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Screen HRC, Knight MM and El Haj A
£504,557 Medical Research Council (24-08-2020 - 23-08-2023)

Summary

Organ-on-a-chip model of breast cancer bone metastases
Knight MM
£269,601 Cancer Research UK (04-01-2021 - 01-07-2023)

Summary

Human tissue-resident immunity to intestinal fungi
McCarthy NE
£153,432 Bart's Charity (30-09-2019 - 31-03-2023)

PhD studentship: Development of an immune-responsive human skin model
Connelly JT
Medical Research Council (01-10-2019 - 01-03-2023)

Fungal suppression by human gut Vdelta2 T-cells in mucosal immunity and inflammation
Mccarthy NE
£547,618 Medical Research Council (02-01-2018 - 01-01-2023)

Summary

QM+Emulate Organs-on-Chips Centre Technician
Knight MM
£49,584 Emulate Inc. (05-04-2021 - 01-01-2023)

Summary

3D Photoelectrochemical imaging in porous light-addressable structures
Krause SK and Zhou B
£202,249 Engineering and Physical Sciences Research Council (01-02-2021 - 31-10-2022)

A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
Biddle AJ, Scemama A and Gautrot JEE
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-09-2022)

Expert technical support for CREATE Lab pump-priming projects
Connelly JT
£240,000 Barts Charity (01-10-2018 - 30-09-2022)

PhD Studentship: Investigation of synovium-cartilage pro-inflammatory cross talk and the role of primary cilia using organ-chip models
Knight MM and Terrazas D
Conacyt Scholarship (16-09-2019 - 15-09-2022)

Combined LAPS and SICM for multimodal live cell imaging
Krause SK and Das A
£571,838 Engineering and Physical Sciences Research Council (01-09-2018 - 31-08-2022)

Novel capsule based smell test for the assessment of hyposmia/anosmia
Ismail ASM
£9,000 EPSRC IAA & STFC IAA (01-12-2020 - 31-03-2022)

Summary

Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopillars
Iskratsch T
£490,544 Biotechnology and Biological Sciences Research Council (01-02-2019 - 31-01-2022)

Summary

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Engineering a human microphysiological platform for modelling soft tissue injury and regeneration
Lin Y-Y
£100,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (04-01-2021 - 11-08-2021)

The Animal Replacement Centre of Excellence
Philpott MP, Biddle AJ and Youssef G
£1,000,000 Animal Free Research UK (01-08-2016 - 31-07-2021)

Organ-on-a-chip Technologies
Screen HRC, Bull AMJ, Haj AJE, Knight MM, Carr AJ, Gunn JPG, Dalby MJ and Workman P
£479,338 Medical Research Council (31-07-2018 - 30-07-2021)

Summary

Understanding the mechnobiology of senescence and ageing
Connelly JT
£134,000 Dunhill Medical Trust (15-04-2019 - 14-06-2021)

CRISPR/Cas9 Engineered Human IPSC Models for Muscular Dystrophy
Lin Y-Y
£490,000 Pfizer (13-11-2017 - 31-03-2021)

A microphysiological human 3D neuromuscular platform for modelling DMD and assessing potential therapeutics
Lin Y-Y
EUR25,000 Duchenne Parent Project (01-02-2020 - 01-02-2021)

Multiscale nuclear mechanobiology within the skin: from biophysical cues to epigenetic effects
Connelly JT and Gavara N
£469,683 Biotechnology and Biological Sciences Research Council (01-05-2017 - 30-04-2020)

Summary

Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degeneration
Krause SK and Das A
£146,591 Horizon 2020 (01-07-2017 - 30-06-2019)

Towards in-vivo electrochemical imaging with flexible, light-addressable electrodes
Krause SK and Fenwick OJ
£15,000 Royal Society (15-03-2018 - 14-03-2019)

Super-resolution Light-Addressable Potentiometric Sensors (LAPS)
Krause SK, Zhang D and Castrejon Pita JR
£147,661 Biotechnology and Biological Sciences Research Council (20-07-2017 - 19-07-2018)

Targeting Feutin-A as an innovative chondroprotective strategy
Perretti M and Kaneva M
William Harvey Research Limited (01-03-2014 - 28-02-2018)

Summary

The role of high frequency loading in the treatment of tendinopathy.
Screen HRC
Orthopaedic Research UK (01-10-2012 - 30-09-2015)

Human tenocyte metabolism under physiological and pathological loading conditions
Screen H
£100,761 Versus Arthritis (03-10-2011 - 02-10-2014)

Summary

Role of JAM-C in inflammatory and vascular events in vivo as studied using an experimental model of ovarian cancer.
Nourshargh S and Balkwill FR
£227,807 Wellcome Trust (01-01-2010 - 31-12-2012)

Summary