The following journal papers published by the members of the CPM, specifically relate to the development and/or use of predictive in vitro models.
2022

Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA,
McArthur S, Purvis GSD, O'Riordan CE, Ferorelli D, Dell'Erba A, Kieswich J, Reutelingsperger C, Maiorano E, Yaqoob M, Thiemermann C, Baragetti A, Catapano AL, Norata GD, Marelli-Berg F, Virgintino D and
Solito E (2022).
Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues. Faseb Journal vol. 36, (1)
10.1096/fj.202101297R2021

Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T,
Solito E, Fonseca S, Carvalho AL, Carding SR, Muller M, Glen RC, Vauzour D and
Mcarthur S (2021).
Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide. Biomed Central Microbiome 10.1186/s40168-021-01181-z
Ciancetta A, Gill AK, Ding T, Karlov DS, Chalhoub G,
McCormick PJ and Tikhonova IG (2021).
Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction. Acs Central Science vol. 7, (11) 1847-1862.
10.1021/acscentsci.1c00802
Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B, Yang F, Liu P, Marino S, Pourquié O, Muntoni F, Wang J, Lieberam I and
Lin YY (2021).
Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections. Science Advances vol. 7, (37)
10.1126/sciadv.abi8787
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M,
Knight MM,
Balkwill FR and Pearce OMT (2021).
A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. Iscience vol. 24, (6)
10.1016/j.isci.2021.102676
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT,
Knight MM and
Balkwill FR (2021).
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. Iscience vol. 24, (6)
10.1016/j.isci.2021.102674
Verbruggen SW,
Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and
Knight MM (2021).
Mechanical stimulation modulates osteocyte regulation of cancer cell phenotype. Cancers vol. 13, (12)
10.3390/cancers13122906
Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y,
Chan LF, Ben-Zvi D,
McCormick PJ, Niv MY and Shalev-Benami M (2021).
Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. Science vol. 372, (6544) 808-814.
10.1126/science.abf7958
Zhou B, Das A, Zhong M, Guo Q, Zhang DW,
Hing KA, Sobrido AJ, Titirici MM and
Krause S (2021).
Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responses. Biosensors and Bioelectronics vol. 180,
10.1016/j.bios.2021.113121
Smith C, Maharaj AV, Qamar Y, Read J, Williams J,
Chan L, Marimuthu V and
Metherell L (2021).
In Vitro Splicing Assay Proves the Pathogenicity of Intronic Variants in MRAP. Journal of The Endocrine Society vol. 5, (Suppl 1) a85-a86.
10.1210/jendso/bvab048.172
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and
Perretti M (2021).
Alpha-1-antitrypsin reduces inflammation and exerts chondroprotection in arthritis. Faseb Journal vol. 35, (5)
10.1096/fj.202001801R
Ismail AS, Goodwin GR, Castrejon-Pita JR, Noyce AJ and Azevedo HS (2021).
A novel capsule-based smell test fabricated via coaxial dripping. The Royal Society Journal of The Royal Society Interface vol. 18, (177)
10.1098/rsif.2021.0039
Lin T, Wang Z,
Wang W and
Sui Y (2021).
A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules. Soft Matter vol. 17, (15) 4027-4039.
10.1039/d0sm02121k
Thompson CL, Fu S,
Heywood HK,
Knight MM and Thorpe SD (2021).
Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models (Front. Bioeng. Biotechnol., (2020), 8, 602646, 10.3389/fbioe.2020.602646). Frontiers in Bioengineering and Biotechnology vol. 9,
10.3389/fbioe.2021.658873
Laly AC, Sliogeryte K, Pundel OJ, Ross R, Keeling MC, Avisetti D, Waseem A, Gavara N and
Connelly JT (2021).
The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction. Science Advances vol. 7, (5)
10.1126/sciadv.abd6187
Lin T, Wang Z, Lu R,
Wang W and
Sui Y (2021).
A high-throughput method to characterize membrane viscosity of flowing microcapsules. Physics of Fluids vol. 33, (1)
10.1063/5.0031640
Maudhoo A, Maharaj A, Buonocore F, Martos-Moreno GA, Argente J, Achermann JC,
Chan LF and
Metherell LA (2021).
Missplicing due to a synonymous, t96= exonic substitution in the t-box transcription factor tbx19 resulting in isolated acth deficiency. Endocrinology, Diabetes and Metabolism Case Reports vol. 2021, (1)
10.1530/EDM-21-01282020

Zamboulis D, Thorpe CT, Ashraf Kharaz Y, Birch HL, Clegg PD and
Screen H (2020).
Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix. Elife Sciences Publications Ltd Elife 10.7554/eLife.58075
Eldridge SE, Barawi A, Wang H, Roelofs AJ,
Kaneva M, GUAN Z, Lydon H, Thomas B, Thorup A-S, Fernandez-Fernandez B, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, McCaskie AW, De Bari C and Dell'Accio F (2020).
Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. American Association For The Advancement of Science Science Translational Medicine vol. 12, (559)
10.1126/scitranslmed.aax9086
Maharaj A, Williams J, Bradshaw T, Güran T, Braslavsky D, Casas J,
Chan LF,
Metherell LA and Prasad R (2020).
Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction. J Steroid Biochem Mol Biol vol. 202,
10.1016/j.jsbmb.2020.105730
Moreno-Delgado D, Puigdellívol M, Moreno E, Rodríguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA, Scarselli M, Casadó V, Cortés A, Ferré S, Guzmán M, Lluís C, Alberch J, Canela EI, Ginés S and
McCormick PJ (2020).
Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease. Elife vol. 9, 1-31.
10.7554/eLife.51093
Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V,
Mcarthur S and
Solito E (2020).
Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier. Biomed Central Journal of Neuroinflammation 10.1186/s12974-020-01810-8
Ma J, Wang Z, Young J, Lai JCS,
Sui Y and Tian FB (2020).
An immersed boundary-lattice Boltzmann method for fluid-structure interaction problems involving viscoelastic fluids and complex geometries. Elsevier Journal of Computational Physics vol. 415,
10.1016/j.jcp.2020.109487
Radvar E,
Shi Y, Grasso S, Edwards-Gayle CJC, Liu X, Mauter MS, Castelletto V, Hamley IW, Reece MJ and Azevedo HS (2020).
Magnetic field-induced alignment of nanofibrous supramolecular membranes: a molecular design approach to create tissue-like biomaterials. American Chemical Society Acs Applied Materials and Interfaces 10.1021/acsami.0c05191
Wu Y,
Wang W, Mata A, Pugno N, Azevedo H, Karabasov S and Titirici M-M (2020).
Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices. Nature Research (Part of Springer Nature) Nature Communications 10.1038/s41467-020-14716-z
Ward M and
Iskratsch T (2020).
Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart. Biochimica Et Biophysica Acta - Molecular Cell Research vol. 1867, (3)
10.1016/j.bbamcr.2019.01.0172019

Zhou B, Das A, Kappers M, Oliver R, Humphreys C and
Krause S (2019).
InGaN as a substrate for AC photoelectrochemical imaging. Mdpi Sensors 10.3390/s19204386
Pang X, O'Malley C, Borges J, Rahman MM, Collis DWP, Mano JF, Mackenzie IC and S. Azevedo H (2019).
Supramolecular Presentation of Hyaluronan onto Model Surfaces for Studying the Behaviour of Cancer Stem Cells. Wiley Advanced Biosystems 1900017-1900017.
10.1002/adbi.201900017
Fu S,
Thompson CL, Ali A,
Wang W,
Chapple JP, Mitchison HM, Beales PL, Wann AKT and
Knight MM (2019).
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthritis and Cartilage vol. 27, (7) 1064-1074.
10.1016/j.joca.2019.03.003
Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL and
Connelly JT (2019).
High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform. Wiley Advanced Biosystems 1900011-1900011.
10.1002/adbi.201900011
Sit B, Gutmann D and
Iskratsch T (2019).
Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing. Journal of Muscle Research and Cell Motility vol. 40, (2) 197-209.
10.1007/s10974-019-09529-7
Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K, Thomas G,
Knight M, Mirnezami A and Peake N (2019).
Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression. Mdpi Ag Cancers 10.3390/cancers11050701
Chineye U, Jones E, Riley G, Morrissey D and
Screen H (2019).
An in vitro investigation into the effects of 10Hz cyclic loading on tenocyte metabolism. Wiley Scandinavian Journal of Medicine and Science in Sports 10.1111/sms.13465
Harris C, THORPE SD, Rushwan S, Wang W,
THOMPSON C, Peacock J,
KNIGHT M, Gooptu B and Greenough A (2019).
An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. Elsevier Journal of Biomechanics 10.1016/j.jbiomech.2019.03.024
Hawkes W, Huang D, Reynolds P, Hammond L,
Ward M, Gadegaard N, Marshall JF, Iskratch T and
Palma M (2019).
Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control. Royal Society of Chemistry (Rsc) Faraday Discussions 10.1039/c9fd00023b
Wang Z,
Sui Y,
Wang W, Barthѐs-Biesel D and Salsac A-V (2019).
Path Selection of a Spherical Capsule in a Branched Channel. Molecular & Cellular Biomechanics vol. 16, (S2) 42-43.
10.32604/mcb.2019.071482018

Liu R, Becer CR and
Screen HRC (2018).
Guided Cell Attachment via Aligned Electrospinning of Glycopolymers. Macromolecular Bioscience vol. 18, (12)
10.1002/mabi.201800293
Ghetti M, Topouzi H, Theocharidis G, Papa V, Williams G, Bondioli E, Cenacchi G,
Connelly JT and Higgins CA (2018).
Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic. British Journal of Dermatology vol. 179, (2) 381-393.
10.1111/bjd.16255
Wang Z,
Sui Y, Salsac AV, Barthès-Biesel D and
Wang W (2018).
Path selection of a spherical capsule in a microfluidic branched channel: Towards the design of an enrichment device. Journal of Fluid Mechanics vol. 849, 136-162.
10.1017/jfm.2018.414
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC,
Knight MM, Philpott MP and
Connelly JT (2018).
Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling. Journal of Cell Science vol. 131, (10) 215780-215780.
10.1242/jcs.215780
PATEL D, Sharma S,
SCREEN HRC and BRYANT S (2018).
Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel. Elsevier Biochemical and Biophysical Research Communications 10.1016/j.bbrc.2018.03.203
Hoyles L, Snelling T, Umlai U-K, Nicholson JK, Carding SR, Glen RC and
MCARTHUR S (2018).
Microbiome-host systems interactions: Protective effects of propionate upon the bloodbrain barrier. Biomed Central Bmc Microbiome vol. 6, 55-55.
10.1186/s40168-018-0439-y
Pandey P, Hawkes W, Hu J, Megone WV,
Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and
Iskratsch T (2018).
Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell vol. 44, (3) 326-336.e3.
10.1016/j.devcel.2017.12.0242017

Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG,
Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C,
Knight M and
Balkwill FR (2017).
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov 10.1158/2159-8290.CD-17-0284
Mafina MK, Sullivan AC and
Hing KA (2017).
Use of a fluorescent probe to monitor the enhanced affinity of rh-BMP-2 to silicated-calcium phosphate synthetic bone graft substitutes under competitive conditions. Materials Science and Engineering C vol. 80, 207-212.
10.1016/j.msec.2017.05.142
Wu F, Campos I, Zhang D and
KRAUSE SK (2017).
Biological imaging using light-addressable potentiometric sensors and scanning photo-induced impedance microscopy. Royal Society, The Proceedings of The Royal Society a: Mathematical, Physical and Engineering Sciences 10.1098/rspa.2017.0130
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and
Perretti M (2017).
Identification of novel chondroprotective mediators in resolving inflammatory exudates. Journal of Immunology vol. 198, (7) 2876-2885.
10.4049/jimmunol.1601111
Patel D, Sharma S, Bryant SJ and
Screen HRC (2017).
Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response. Advanced Healthcare Materials vol. 6, (4)
10.1002/adhm.2016010952016

Sharili AS, Kenny FN, Vartiainen MK and
Connelly JT (2016).
Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes. Sci Rep vol. 6, 33893-33893.
10.1038/srep33893
Zhang DW, Wu F, Wang J, Watkinson M and
KRAUSE SK (2016).
Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS). Electrochemistry Communications vol. 72, 41-45.
10.1016/j.elecom.2016.08.017
Mozdzen L, Thorpe S,
SCREEN HRC and Harley B (2016).
The effect of gradations in mineral content, matrix alignment, and applied strain on human mesenchymal stem cell morphology within collagen biomaterials. Wiley: 12 Months Advanced Healthcare Materials 10.1002/adhm.201600181
Kao AP,
Connelly JT and Barber AH (2016).
3D nanomechanical evaluations of dermal structures in skin. Journal of The Mechanical Behavior of Biomedical Materials vol. 57, 14-23.
10.1016/j.jmbbm.2015.11.017
Theocharidis G, Drymoussi Z, Kao AP, Barber AH,
Lee DA, Braun KM and
Connelly JT (2016).
Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol vol. 136, (1) 74-83.
10.1038/JID.2015.3522015

Thorpe CT, Chaudhry S, Lei II, Varone A, Riley GP, Birch HL, Clegg PD and
Screen HRC (2015).
Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation. Scandinavian Journal of Medicine and Science in Sports vol. 25, (4) e381-e391.
10.1111/sms.12333
Screen HRC, Berk DE, Kadler KE, Ramirez F and Young MF (2015).
Tendon functional extracellular matrix. Journal of Orthopaedic Research vol. 33, (6) 793-799.
10.1002/jor.22818
Almeida FV, Walko G, McMillan JR, McGrath JA, Wiche G, Barber AH and
Connelly JT (2015).
The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes. Journal of Cell Science vol. 128, (24) 4475-4486.
10.1242/jcs.1734352014
Kaneva MK, Kerrigan MJP, Grieco P, Curley GP, Locke IC and Getting SJ (2014).
Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Biochem Pharmacol vol. 92, (2) 336-347.
10.1016/j.bcp.2014.08.019
Greco KV, Nalesso G,
Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F and
Perretti M (2014).
Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol vol. 91, (3) 348-358.
10.1016/j.bcp.2014.07.034
Shah FA, Brauer DS, Wilson RM, Hill RG and
Hing KA (2014).
Influence of cell culture medium composition on in vitro dissolution behavior of a fluoride-containing bioactive glass. Journal of Biomedical Materials Research - Part A vol. 102, (3) 647-654.
10.1002/jbm.a.347242013

Shafat M, Rajakumar K, Syme H, Buchholz N and
Knight MM (2013).
Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference? Urolithiasis vol. 41, (6) 481-486.
10.1007/s00240-013-0608-1
Campion CR, Ball SL, Clarke DL and
Hing KA (2013).
Microstructure and chemistry affects apatite nucleation on calcium phosphate bone graft substitutes. Journal of Materials Science: Materials in Medicine vol. 24, (3) 597-610.
10.1007/s10856-012-4833-x
Mafina M-K,
Hing KA and Sullivan AC (2013).
Development of novel fluorescent probes for the analysis of protein interactions under physiological conditions with medical devices. Langmuir vol. 29, (5) 1420-1426.
10.1021/la304244s
Legerlotz K, Jones GC,
Screen HRC and Riley GP (2013).
Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes. Scandinavian Journal of Medicine and Science in Sports vol. 23, (1) 31-37.
10.1111/j.1600-0838.2011.01410.x2012

Driskell RR, Juneja VR,
Connelly JT, Kretzschmar K, Tan DW-M and Watt FM (2012).
Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo. J Invest Dermatol vol. 132, (4) 1084-1093.
10.1038/jid.2011.428
Trappmann B,
Gautrot JE,
Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM and Huck WTS (2012).
Extracellular-matrix tethering regulates stem-cell fate. Nature Materials 10.1038/nmat33392011

Guth K, Campion C, Buckland T and
Hing KA (2011).
Effects of serum protein on ionic exchange between culture medium and microporous hydroxyapatite and silicate-substituted hydroxyapatite. Journal of Materials Science: Materials in Medicine vol. 22, (10) 2155-2164.
10.1007/s10856-011-4409-12010
Connelly JT,
Gautrot JE, Trappmann B, Tan DWM, Donati G, Huck WTS and Watt FM (2010).
Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biology vol. 12, (7) 711-718.
10.1038/ncb2074
Connelly JT, Vanderploeg EJ, Mouw JK, Wilson CG and Levenston ME (2010).
Tensile loading modulates bone marrow stromal cell differentiation and the development of engineered fibrocartilage constructs. Tissue Eng Part A vol. 16, (6) 1913-1923.
10.1089/ten.TEA.2009.0561
Guth K, Campion C, Buckland T and
Hing KA (2010).
Surface physiochemistry affects protein adsorption to stoichiometric and silicate-substituted microporous hydroxyapatites. Advanced Engineering Materials vol. 12, (4)
10.1002/adem.200980026
Screen HRC, Byers S, Lynn AD, Nguyen V, Patel D and Bryant SJ (2010).
Characterization of a novel fiber composite material for mechanotransduction research of fibrous connective tissues. Advanced Functional Materials vol. 20, (5) 738-747.
10.1002/adfm.200901711
Guth K, Campion C, Buckland T and
Hing KA (2010).
Effect of silicate-substitution on attachment and early development of human osteoblast-like cells seeded on microporous hydroxyapatite discs. Advanced Engineering Materials vol. 12, (1-2)
10.1002/adem.2009800032008
Connelly JT, García AJ and Levenston ME (2008).
Interactions between integrin ligand density and cytoskeletal integrity regulate BMSC chondrogenesis. J Cell Physiol vol. 217, (1) 145-154.
10.1002/jcp.21484
Rashid N, Harding I, Buckland T and
HING KA (2008).
Nano-scale manipulation of silicate-substituted apatite chemistry impacts surface charge, hydrophilicity, protein adsorption and cell attachment., Editors: Meenan BJ and Boyd AR.
International Journal of Nano and Biomaterials vol. 1, (3) 299-319.
10.1504/IJNBM.2008.0168772007