Cardiovascular Models

Cardiovascular disease is a leading cause of death in the UK and its social and economic cost is increasing constantly due to our ageing society. Queen Mary University of London (QMUL) has a longstanding commitment to world-leading research to better understand and treat heart disease. Activities include the development of innovative cardiovascular devices at the Centre for Cardiovascular Medicine and Device Innovation (CVDHub), as well as basic and translational cardiovascular research at the William Harvey Research Institute (WHRI), or molecular and computational cardiovascular engineering at the School of Engineering and Materials Science

The Centre for Predictive In Vitro Models (CPM) ties in directly with these activities by focusing on advanced three dimensional vascular networks and cardiac tissues for improving understanding of disease mechanisms and development of novel treatments. Currently ongoing state-of-the art projects include bioprinted vessels-on-a-chip (Gautrot Lab), vascular disease modelling based on induced pluripotent stem cells and models for studying vascular endothelial mechanosensing (Xiao Lab, Wang Lab, Krams Lab), bio-nanoarrays to study cardiomyocyte and vascular smooth muscle cell receptor-ligand interactions (Palma Lab, Iskratsch Lab), force sensing nanopillar arrays to measure cardiomyocyte contraction dynamics, or engineered heart tissues for investigating the effects of cardiac disease causing mutations or cardiotoxicity of drugs (Iskratsch Lab, Lin Lab, Tinker Lab).

People

  • Prof Thomas Iskratsch
    Theme Lead for Cardiovascular Models
    Professor of Cardiovascular Mechanobiology and Bioengineering, Queen Mary University of London
  • Dr Vahitha Abdul Salam
    Lecturer, Queen Mary University of London
  • Prof Amrita Ahluwalia
    Dean For Research Faculty of Medicine and Dentistry, QMUL
  • Prof Jesmond Dalli
    Professor in Molecular Pharmacology, Barts and The London School of Medicine and Dentistry
  • Dr Neil Dufton
    Lecturer in Inflammatory Sciences, Faculty of Medicine and Dentistry, Queen Mary University of London
  • Professor Paul Evans
    Professor of Vascular Metabolism, QMUL
  • Prof Julien Gautrot
    Professor of Biomaterials and Biointerfaces, Queen Mary University of London
  • Prof Steve Greenwald
    Professor of Cardiovascular Mechanics, Faculty of Medicine and Dentistry, Queen Mary University of London
  • Dr. Muhammad Salman Haleem
    Lecturer (Assistant Professor) in Computer Science, Electronic Engineering and Computer Science
  • Prof Adrian Hobbs
    Professor of Cardiovascular Pharmacology, Faculty of Medicine and Dentistry, Queen Mary University of London
  • Prof David Kelsell
    Professor of Human Molecular Genetics, Faculty of Medicine and Dentistry, Queen Mary University of London
  • Prof Martin Knight
    Professor of Mechanobiology, Dean for Research, Queen Mary University of London
  • Prof Rob Krams
    Professor of Molecular Bioengineering, Queen Mary University of London
  • Prof David Lee
    Professor of Cell & Tissue Engineering, Queen Mary University of London
  • Dr Yung-Yao Lin
    Senior Lecturer, Faculty of Medicine and Dentistry, Queen Mary University of London
  • Dr Pradeepa Madapura
    Senior Lecturer, Faculty of Medicine and Dentistry
  • Dr Simon McArthur
    Senior Lecturer in Neuroscience and Pharmacology, Faculty of Medicine and Dentistry, Queen Mary University of London
  • Prof Lou Metherell
    Professor of Endocrine Genetics, Faculty of Medicine and Dentistry, Queen Mary University of London
  • Dr Tom Nightingale
    Senior Lecturer, Faculty of Medicine and Dentistry, Queen Mary University of London
  • Prof Mauro Perretti
    Professor of Immunopharmacology, Queen Mary University of London
  • Dr Caroline Roney
    Lecturer in Computational Medicine, Queen Mary University of London
  • Prof Hazel Screen
    Professor of Biomedical Engineering, Queen Mary University of London
  • Prof Greg Slabaugh
    Director of the Digital Environment Research Institute, Queen Mary University of London
  • Dr Manikandan Subramanian
    Senior Lecturer, William Harvey Research Institute
  • Prof Yi Sui
    Professor of Fluid Mechanics, Queen Mary University of London
  • Prof Andrew Tinker
    , Faculty of Medicine and Dentistry, Queen Mary University of London
  • Prof Zion Tse
    Academy of Medical Sciences Professor in Bioengineering, Queen Mary University of London
  • Prof Wen Wang
    Vice-Principal and Executive Dean, Queen Mary University of London
  • Prof Qingzhong Xiao
    Professor of Stem Cell and Cardiovascular Disease, Faculty of Medicine and Dentistry, Queen Mary University of London