Professor Wen Wang

Wen Wang

Vice President (Science and Engineering)

School of Engineering and Materials Science
Queen Mary University of London

Research

Vascular mechanics, Cell engineering, Endothelial glycocalyx, Modelling and simulation, Circulating cells

Cardiovascular Models

Interests

My work focuses on vascular bioengineering and biomaterial mechanics, including studies on the endothelial glycocalyx, vascular stem cells and progenator cells, transmembrane and transcapillary exchange. We are interested in developing in vitro models to study fundamental vascular mechanobiology and involvement in disease.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2026

Real-time high-throughput characterisation of the surface elasticity of suspended cells
Guo Z, Sui Y, Wang W
Lab On a Chip, Royal Society of Chemistry (Rsc) 
01-01-2026

2025

Bacteria extracellular vesicles derived from Lactobacillus reuteri delivering intrinsic miR-21a-5p to accelerate diabetic wound healing
Li Y, Zheng Z, Kong X, Wang Y, Liu Z, Wang W, Hu H, Xu F et al.
Nano Research, Tsinghua University Press vol. 18 (11) 
01-11-2025
Hydrogel empowered extracellular vesicles isolation, detection, and delivery
Li Y, Liu Z, Zheng Z, Bai L, Wang W, Min L, Hu H, Shi Y
Nano Today, Elsevier vol. 64 
01-10-2025
Harnessing the therapeutic potential of bacterial extracellular vesicles via functional peptides
Shi Y, Zheng Z, Wang W, Hu H
Interdisciplinary Medicine, Wiley vol. 3 (4) 
23-03-2025

2024

An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z et al.
European Journal of Cell Biology, Elsevier vol. 103 (4) 
24-10-2024
Droplets can enhance microcapsule deformation in channel flow
Jing D, Lu R, Farutin A, Guo Z, Wang F, Wang W, Misbah C, Sui Y
Communications Physics, Springer Nature vol. 7 (1) 
20-09-2024
A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT et al.
Advanced Healthcare Materials, Wiley vol. 13 (17) 
22-03-2024
Highly sensitive SERS platform for pathogen analysis by cyclic DNA nanostructure@AuNP tags and cascade primer exchange reaction
Xiao Y, Luo S, Qiu J, Zhang Y, Liu W, Zhao Y, Zhu Y, Deng Y et al.
Journal of Nanobiotechnology, Springer Nature vol. 22 (1) 
26-02-2024

2023

A sensitive and rapid electrochemical biosensor for sEV-miRNA detection based on domino-type localized catalytic hairpin assembly
Li W, Wang W, Luo S, Chen S, Ji T, Li N, Pan W, Zhang X et al.
Journal of Nanobiotechnology, Springer Nature vol. 21 (1) 
09-09-2023
Core–Shell-Structured Electrorheological Fluid with a Polarizability-Tunable Nanocarbon Shell for Enhanced Stimuli-Responsive Activity
Chen S, Cheng Y, Zhao Z, Zhang K, Hao T, Sui Y, Wang W, Zhao J et al.
Acs Applied Materials & Interfaces, American Chemical Society (Acs) vol. 15 (29), 35741-35749.  
14-07-2023
Rapid and efficient fluorescent aptasensor for PD-L1 positive extracellular vesicles isolation and analysis: EV-ANCHOR
Feng J, Jia L, Pan W, Fan Y, Guo J, Luo T, Liu C, Wang W et al.
Chemical Engineering Journal, Elsevier vol. 465 
01-06-2023
A method for real-time mechanical characterisation of microcapsules
Guo Z, Lin T, Jing D, Wang W, Sui Y
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 22 (4), 1209-1220.  
24-03-2023
A computational model for the transit of a cancer cell through a constricted microchannel
Wang Z, Lu R, Wang W, Tian FB, Feng JJ, Sui Y
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 22 (4), 1129-1143.  
28-02-2023
A simple and sensitive electrochemical biosensor for circulating tumor cell determination based on dual-toehold accelerated catalytic hairpin assembly
Zhang X, Jiang X, Wang W, Luo S, Guan S, Li W, Situ B, Li B et al.
Microchimica Acta, Springer Nature vol. 190 (2) 
24-01-2023

2022

Localized DNA tetrahedrons assisted catalytic hairpin assembly for the rapid and sensitive profiling of small extracellular vesicle-associated microRNAs
Zhang Y, Li W, Ji T, Luo S, Qiu J, Situ B, Li B, Zhang X et al.
Journal of Nanobiotechnology, Springer Nature vol. 20 (1) 
01-12-2022
[Retracted] Diagnostic Value of IGFBP‐2 in Predicting Preeclampsia before 20 Weeks of Pregnancy: A Prospective Nested Case‐Control Study
Gao F, Yin J, Long Y, Zhu S, Huang Z, Wang J, Zheng H, Wang W et al.
Computational and Mathematical Methods in Medicine, Hindawi vol. 2022 (1) 
28-09-2022
Extracellular Vesicles of Mesenchymal Stem Cells Are More Effectively Accessed through Polyethylene Glycol‐Based Precipitation than by Ultracentrifugation
Jia L, Li B, Fang C, Liang X, Xie Y, Sun X, Wang W, Zheng L et al.
Stem Cells International, Hindawi vol. 2022 (1) 
06-09-2022
Disinfector‐Assisted Low Temperature Reduced Graphene Oxide‐Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma
Wu Y, Yang J, van Teijlingen A, Berardo A, Corridori I, Feng J, Xu J, Titirici M et al.
Advanced Functional Materials, Wiley vol. 32 (38) 
08-07-2022
Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network
Lin T, Wang Z, Lu RX, Wang W, Sui Y
Advances in Applied Mathematics and Mechanics, Global Science Press vol. 14 (1), 79-100.  
01-06-2022
Investigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging
Zhang Y, Hollis D, Ross R, Snow T, Terrill NJ, Lu Y, Wang W, Connelly J et al.
Materials, Mdpi vol. 15 (5) 
01-03-2022

2021

Growth and self-jumping of single condensed droplet on nanostructured surfaces: A molecular dynamics simulation
Pu JH, Wang SK, Sun J, Wang W, Wang HS
Journal of Molecular Liquids, Elsevier vol. 340 
01-10-2021
The role of actomyosin in the regulation of syndecan-1 in hyperosmosis
Li W, Wang W
Biochimica Et Biophysica Acta (Bba) - General Subjects, Elsevier vol. 1865 (10) 
31-07-2021
Path selection of a train of spherical capsules in a branched microchannel
Lu RX, Wang Z, Salsac A-V, Barthès-Biesel D, Wang W, Sui Y
Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 923 
22-07-2021
Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion
Pang X, Li W, Chang L, Gautrot JE, Wang W, Azevedo HS
Acs Applied Materials & Interfaces, American Chemical Society (Acs) vol. 13 (22), 25792-25804.  
26-05-2021
An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability.
Wu Y, Fortunato GM, Okesola BO, Brocchetti FLPD, Suntornnond R, Connelly J, De Maria C, Rodriguez-Cabello JC et al.
Biofabrication, Iop Publishing vol. 13 (3) 
08-04-2021
Stable and Efficient Nanofilm Pure Evaporation on Nanopillar Surfaces
Pu JH, Wang SK, Sun J, Wang W, Wang HS
Langmuir, American Chemical Society (Acs) vol. 37 (12), 3731-3739.  
18-03-2021
The Identification of Plasma Exosomal miR-423-3p as a Potential Predictive Biomarker for Prostate Cancer Castration-Resistance Development by Plasma Exosomal miRNA Sequencing
Guo T, Wang Y, Jia J, Mao X, Stankiewicz E, Scandura G, Burke E, Xu L et al.
Frontiers in Cell and Developmental Biology, Frontiers vol. 8 
07-01-2021
Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson CL, Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 29 (1), 89-99.  
01-01-2021
A high-throughput method to characterize membrane viscosity of flowing microcapsules
Lin T, Wang Z, Lu R, Wang W, Sui Y
Physics of Fluids, Aip Publishing vol. 33 (1) 
01-01-2021
A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules
Lin T, Wang Z, Wang W, Sui Y
Soft Matter, Royal Society of Chemistry (Rsc) vol. 17 (15), 4027-4039.  
01-01-2021
Correction: A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules
Lin T, Wang Z, Wang W, Sui Y
Soft Matter, Royal Society of Chemistry (Rsc) vol. 17 (15), 4213-4213.  
01-01-2021
Molecular Dynamics Simulation of Effect of Temperature Difference on Surface Condensation
Pu JH, Sheng Q, Sun J, Wang W, Wang HS
In Advances in Heat Transfer and Thermal Engineering, Springer Nature 99-103.  
01-01-2021

2020

miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia
He S, Yang F, Yang M, An W, Maguire EM, Chen Q, Xiao R, Wu W et al.
Stem Cell Research & Therapy, Springer Nature vol. 11 (1) 
03-11-2020
Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices
Wu Y, Okesola BO, Xu J, Korotkin I, Berardo A, Corridori I, di Brocchetti FLP, Kanczler J et al.
Nature Communications, Springer Nature vol. 11 (1) 
04-03-2020
Generation and Evolution of Nanobubbles on Heated Nanoparticles: A Molecular Dynamics Study
Pu JH, Sun J, Wang W, Wang HS
Langmuir, American Chemical Society (Acs) vol. 36 (9), 2375-2382.  
03-02-2020
A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3γ phosphorylation
Yang J, Moraga A, Xu J, Zhao Y, Luo P, Lao KH, Margariti A, Zhao Q et al.
Stem Cells, Oxford University Press (Oup) vol. 38 (4), 556-573.  
29-01-2020
Problematic Internet Use, Non-Medical Use of Prescription Drugs, and Depressive Symptoms among Adolescents: A Large-Scale Study in China
Fan B, Wang W, Wang T, Xie B, Zhang H, Liao Y, Lu C, Guo L
International Journal of Environmental Research and Public Health, Mdpi vol. 17 (3) 
26-01-2020

2019

Dependences of Formation and Transition of the Surface Condensation Mode on Wettability and Temperature Difference
Pu JH, Sun J, Sheng Q, Wang W, Wang HS
Langmuir, American Chemical Society (Acs) vol. 36 (1), 456-464.  
15-12-2019
Heparanase-Dependent Remodeling of Initial Lymphatic Glycocalyx Regulates Tissue-Fluid Drainage During Acute Inflammation in vivo
Arokiasamy S, King R, Boulaghrasse H, Poston RN, Nourshargh S, Wang W, Voisin M-B
Frontiers in Immunology, Frontiers vol. 10 
04-10-2019
Membrane tension regulates syndecan-1 expression through actin remodelling
Li W, Wang W
Biochimica Et Biophysica Acta (Bba) - General Subjects, Elsevier vol. 1863 (11) 
08-08-2019
Dependence of nano-confined surface condensation on tangentially external force field
Pu JH, Sheng Q, Sun J, Wang W, Wang HS
Journal of Molecular Liquids, Elsevier vol. 283, 440-450.  
01-06-2019
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT et al.
Osteoarthritis and Cartilage, Elsevier vol. 27 (7), 1064-1074.  
25-03-2019
Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces
Pang X, Li W, Landwehr E, Yuan Y, Wang W, Azevedo HS
Faraday Discussions, Royal Society of Chemistry (Rsc) vol. 219, 168-182.  
01-01-2019
Biofluids: Microcirculation
Lu Y, Wang W
In Comprehensive Biotechnology 32-46.  
01-01-2019
Path Selection of a Spherical Capsule in a Branched Channel
Wang Z, Sui Y, Wang W, Barthѐs-Biesel D, Salsac A-V
Molecular & Cellular Biomechanics, Tech Science Press vol. 16 (S2), 42-43.  
01-01-2019

2018

A fate-alternating transitional regime in contracting liquid filaments
Wang F, Contò FP, Naz N, Castrejón-Pita JR, Castrejón-Pita AA, Bailey CG, Wang W, Feng JJ et al.
Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 860, 640-653.  
10-12-2018
Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy
Peng J, Wang W, Zheng L, Guan Y, Ye G, Tong H, Wang Y, Wang Q
Lab Medicine, Oxford University Press (Oup) vol. 50 (2), 163-167.  
04-12-2018
Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes.
Tang P, di Cio S, Wang W, E Gautrot J
Langmuir vol. 34 (34), 10019-10027.  
28-08-2018
Bayes' theorem-based binary algorithm for fast reference-less calibration of a multimode fiber.
Zhao T, Deng L, Wang W, Elson DS, Su L
Optics Express, Optica Publishing Group vol. 26 (16), 20368-20378.  
26-07-2018
Path selection of a spherical capsule in a microfluidic branched channel: Towards the design of an enrichment device
Wang Z, Sui Y, Salsac AV, Barthès-Biesel D, Wang W
Journal of Fluid Mechanics vol. 849, 136-162.  
18-06-2018
Bifunctional aptamer-mediated catalytic hairpin assembly for the sensitive and homogenous detection of rare cancer cells
Liu J, Zhang Y, Zhao Q, Situ B, Zhao J, Luo S, Li B, Yan X et al.
Analytica Chimica Acta, Elsevier vol. 1029, 58-64.  
04-05-2018
The interaction between XBP1 and eNOS contributes to endothelial cell migration
Yang J, Xu J, Danniel M, Wang X, Wang W, Zeng L, Shen L
Experimental Cell Research, Elsevier vol. 363 (2), 262-270.  
17-01-2018
DETECTION OF LIQUID-VAPOUR INTERFACE IN MOLECULAR DYNAMICS SIMULATION
Sheng Q, Sun J, You X, Wang W, Wang HS
International Heat Transfer Conference 16. 
01-01-2018
Hsa_Circ_0001275: A Potential Novel Diagnostic Biomarker for Postmenopausal Osteoporosis
Zhao K, Zhao Q, Guo Z, Chen Z, Hu Y, Su J, Chen L, He Z et al.
Cellular Physiology and Biochemistry, Karger Publishers vol. 46 (6), 2508-2516.  
01-01-2018

2017

How solid surface free energy determines coalescence-induced nanodroplet jumping: A molecular dynamics investigation
Sheng Q, Sun J, Wang W, Wang HS, Bailey CG
Journal of Applied Physics, Aip Publishing vol. 122 (24) 
27-12-2017
Effects of High Pressure on Phospholipid Bilayers
Ding W, Palaiokostas M, Shahane G, Wang W, Orsi M
The Journal of Physical Chemistry B, American Chemical Society (Acs) vol. 121 (41), 9597-9606.  
05-10-2017
118A novel method to determine left atrial compliance in vivo: relationship with markers of remodelling in AF
Norton R, Honarbakshs S, Wang W, Schilling R, Hunter R
Ep Europace, Oxford University Press (Oup) vol. 19 (suppl_1), i49-i49.  
01-10-2017
Structural alteration of the endothelial glycocalyx: contribution of the actin cytoskeleton
Li W, Wang W
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 17 (1), 147-158.  
14-08-2017
Surface texturing of electrospun fibres by photoembossing using pulsed laser interference holography and its effects on endothelial cell adhesion
Hughes-Brittain NF, Qiu L, Picot OT, Wang W, Peijs T, Bastiaansen CWM
Polymer (United Kingdom) vol. 125, 40-49.  
26-07-2017
A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective
Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A et al.
Circulation, Wolters Kluwer vol. 136 (11), 1022-1036.  
03-07-2017
Characterisation of the lymphatic endothelium glycocalyx and its regulation during acute inflammation in vivo
Arokiasamy S, Nourshargh S, Wang W, Voisin M-B
NA. 
01-06-2017
Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation
Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S, Voisin M-B
Scientific Reports, Springer Nature vol. 7 (1) 
13-03-2017

2016

Responses of Vascular Endothelial Cells to Photoembossed Topographies on Poly(Methyl Methacrylate) Films
Qiu L, Hughes-Brittain NF, Bastiaansen CWM, Peijs T, Wang W
Journal of Functional Biomaterials, Mdpi vol. 7 (4) 
09-12-2016
Degradation and biocompatibility of photoembossed PLGA–acrylate blend for improved cell adhesion
Hughes‐Brittain NF, Qiu L, Wang W, Peijs T, Bastiaansen CWM
Journal of Biomedical Materials Research Part B Applied Biomaterials, Wiley vol. 106 (1), 163-171.  
02-12-2016
Motion of a spherical capsule in branched tube flow with finite inertia
Wang Z, Sui Y, Salsac A-V, Barthès-Biesel D, Wang W
Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 806, 603-626.  
13-10-2016
Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale
Mo J, Prévost SF, Blowes LM, Egertová M, Terrill NJ, Wang W, Elphick MR, Gupta HS
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 113 (42), e6362-e6371.  
05-10-2016
On the onset of surface condensation: formation and transition mechanisms of condensation mode
Sheng Q, Sun J, Wang Q, Wang W, Wang HS
Scientific Reports, Springer Nature vol. 6 (1) 
02-08-2016
Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation
Yu B, Wong MM, Potter CMF, Simpson RML, Karamariti E, Zhang Z, Zeng L, Warren D et al.
Stem Cells, Oxford University Press (Oup) vol. 34 (9), 2368-2380.  
28-06-2016
A target-triggered dual amplification strategy for sensitive detection of microRNA
Lv W, Zhao J, Situ B, Li B, Ma W, Liu J, Wu Z, Wang W et al.
Biosensors and Bioelectronics, Elsevier vol. 83, 250-255.  
19-04-2016
Molecular Simulation of Lipids and Water: Atomistic, Coarse-Grained, and Mixed Resolutions
Orsi M, Ding W, Palaiokostas M, Wang W
 
01-02-2016
Atomistic and Coarse-Grained Molecular Simulations of Mixed Lamellar/Nonlamellar Lipid Membranes
Ding W, Palaiokostas M, Wang W, Orsi M
 
01-02-2016

2015

Electrochemical determination of microRNAs based on isothermal strand-displacement polymerase reaction coupled with multienzyme functionalized magnetic micro-carriers
Ma W, Situ B, Lv W, Li B, Yin X, Vadgama P, Zheng L, Wang W
Biosensors and Bioelectronics, Elsevier vol. 80, 344-351.  
21-12-2015
Effects of Lipid Composition on Bilayer Membranes Quantified by All-Atom Molecular Dynamics
Ding W, Palaiokostas M, Wang W, Orsi M
The Journal of Physical Chemistry B, American Chemical Society (Acs) vol. 119 (49), 15263-15274.  
24-11-2015
IFT88 influences chondrocyte actin organization and biomechanics
Wang Z, Wann AKT, Thompson CL, Hassen A, Wang W, Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 24 (3), 544-554.  
19-10-2015
XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X et al.
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (10), 2134-2144.  
27-08-2015
Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J et al.
Cell Death and Differentiation vol. 22 (7), 1170-1180.  
01-07-2015
Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling*
Wang X, Karamariti E, Simpson R, Wang W, Xu Q
Journal of Biological Chemistry, Elsevier vol. 290 (32), 19844-19852.  
23-06-2015
Abstract 662: X-box Binding Protein 1 Splicing Promotes Wound Healing via Modulating Endothelial Nitric Oxide Synthase
Yang J, Zeng L, Wang W, Li Y
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (suppl_1) 
01-05-2015
Abstract 200: Vascular Stem Cell Migration in Response to Monocyte Chemoattractant Protein-1 Promotes Neointima Lesion Formation
Yu B, Wong MM, Wang W, Hu Y, Xu Q
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (suppl_1) 
01-05-2015
Abstract 9: Smooth Muscle Cells Are Crucial for Vascular Stem Cell Migration and Vasculogenesis via Keratinocyte Cell-derived Chemokine
Yu B, Wong MM, Potter C, Hu Y, Wang W, Xu Q
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (suppl_1) 
01-05-2015
Histone deacetylases and cardiovascular cell lineage commitment.
Yang J-Y, Wang Q, Wang W, Zeng L-F
World Journal of Stem Cells, Baishideng Publishing Group vol. 7 (5), 852-858.  
01-01-2015

2014

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J et al.
Cell Death & Differentiation, Springer Nature vol. 22 (7), 1170-1180.  
19-12-2014
Microcapsules functionalized with neuraminidase can enter vascular endothelial cells in vitro.
Liu W, Wang X, Bai K, Lin M, Sukhorukov G, Wang W
J R Soc Interface vol. 11 (101) 
06-12-2014
The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes
Wang Z, Irianto J, Kazun S, Wang W, Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 23 (2), 289-299.  
11-11-2014
Biofunctionalization of PEGylated microcapsules for exclusive binding to protein substrates.
Deo DI, Gautrot JE, Sukhorukov GB, Wang W
Biomacromolecules vol. 15 (7), 2555-2562.  
14-07-2014
Viscous dissipation effect in nano-confined shear flows: a comparative study between molecular dynamics and multi-scale hybrid simulations
Sun J, Wang W, Wang HS
Microfluidics and Nanofluidics, Springer Link 
01-05-2014
Photoembossing of surface relief structures in polymer films for biomedical applications.
Hughes-Brittain NF, Qiu L, Wang W, Peijs T, Bastiaansen CWM
J Biomed Mater Res B Appl Biomater vol. 102 (2), 214-220.  
01-02-2014
Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro
Bai K, Wang W
Biomechanics and Modeling in Mechanobiology vol. 13 (2), 303-311.  
01-01-2014
Converging Parallel Plate Flow Chambers for Studies on the Effect of the Spatial Gradient of Wall Shear Stress on Endothelial Cells
Lu$y.lu@derby.ac.uk$School of Engineering and Technology Y, University of Derby, Derby, Science UW-QLSOEAM, Mary, University of London, London, Oraifige$School of Engineering and Technology UI et al.
Journal of Biosciences and Medicines, Scientific Research Publishing vol. 02 (02), 50-56.  
01-01-2014

2013

Three-dimensional dynamics of oblate and prolate capsules in shear flow
Wang Z, Sui Y, Spelt PDM, Wang W
Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, American Physical Society vol. 88 
26-11-2013
Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2.
Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z et al.
J Biol Chem vol. 288 (44), 31853-31866.  
01-11-2013
MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1.
Luo Z, Wen G, Wang G, Pu X, Ye S, Xu Q, Wang W, Xiao Q
Stem Cells vol. 31 (9), 1749-1762.  
01-09-2013
Numerical simulation of the hydrodynamics of endothelial glycocalyx under shear flow
Ye S, Wang W, Shao X
Ieee International Conference On Control and Automation Icca, 923-928.  
26-08-2013
Abstract 004: Microrna-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells By Targeting Methyl Cpg Binding Protein 2
Zhao H, Huang Y, Yu X, Wen G, Wang W, Ye S, Xiao Q
Circulation Research, Wolters Kluwer vol. 113 (suppl_1) 
01-08-2013
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J et al.
Circulation vol. 127 (16), 1712-1722.  
23-04-2013
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation
Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q et al.
Journal of Biological Chemistry vol. 288 (2), 859-872.  
11-01-2013
Dependence of nanoconfined liquid behavior on boundary and bulk factors
Sun J, Wang W, Wang HS
Physical Review E: Statistical, Nonlinear, and Soft Matter Physics vol. 87 
01-01-2013
Dependence between velocity slip and temperature jump in shear flows
Sun J, Wang W, Wang HS
The Journal of Chemical Physics, American Institute of Physics vol. 138 (23) 
01-01-2013
Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro
Bai K, Wang W
Biomechanics and Modeling in Mechanobiology, 1-9.  
01-01-2013
MicroRNA-34a Regulated Sirtuin 1 is Required for Smooth Muscle Cell Differentiation From Murine and Human Embryonic Stem Cells
Yu X, Zhang L, Wen G, Zhao H, Huang Y, Zhu J, Xu Q, Ye S et al.
 
01-01-2013

2012

Spatio-temporal development of the endothelial glycocalyx layer and its mechanical property in vitro
Bai K, Wang W
Journal of The Royal Society Interface vol. 9 (74), 2290-2298.  
07-09-2012
Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels.
Lu Y, Michel CC, Wang W
J Appl Physiol (1985) vol. 113 (3), 487-497.  
01-08-2012
Contribution of stem cells to neointimal formation of decellularized vessel grafts in a novel mouse model
Tsai TN, Kirton JP, Campagnolo P, Zhang L, Xiao Q, Zhang Z, Wang W, Hu Y et al.
American Journal of Pathology vol. 181 (1), 362-373.  
01-07-2012
Left atrial wall stress distribution and its relationship to electrophysiologic remodeling in persistent atrial fibrillation
Hunter RJ, Liu Y, Lu Y, Wang W, Schilling RJ
Circulation Arrhythmia and Electrophysiology vol. 5 (2), 351-360.  
01-04-2012
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA
Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.  
01-01-2012
Microrna-200c and-150 Play a Role in Human Embryonic Stem Cell Differentiation Into Endothelial Cells and Blood Vessel Formation by Targeting Transcription Repressor Zebi
Luo Z, Wen G, Wang G, Pu X, Wang W, Ye S, Xu Q, Xiao Q
Circulation vol. 126 (21) 
01-01-2012

2011

DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TOWARDS THE ENDOTHELIAL LINEAGE INVOLVES MICRORNAS
Luo Z, Xiao Q, Wang W, Xu Q
Heart vol. 97 (20), 4-4.  
01-10-2011
Biofluids
Lu Y, Wang W
In Comprehensive Biotechnology Second Edition 237-250.  
09-09-2011
Simulated Microgravity, Erythroid Differentiation, and the Expression of Transcription Factor GATA-1 in CD34(+) Cells
Zheng L, Liu JZ, Hu YW, Zhong TY, Xiong SL, Wang W, Wang Q
Aviat Space Envir Md vol. 82 (5), 513-517.  
01-05-2011
Taylor dispersion in finite-length capillaries
Vikhansky A, Wang W
Chem Eng Sci vol. 66 (4), 642-649.  
15-02-2011
Inbuilt mechanisms for overcoming functional problems inherent in hepatic microlobular structure.
Cohen RD, Brown CL, Nickols C, Levey P, Boucher BJ, Greenwald SE, Wang W
Comput Math Methods Med vol. 2011 
01-01-2011
Signalling pathways that regulate endothelial differentiation from stem cells
Luo ZL, Wang G, Wang W, Xiao QZ, Xu QB
Front Biosci-Landmrk vol. 16, 472-485.  
01-01-2011
5.19 Biofluids | Microcirculation
Lu Y, Wang W
In Comprehensive Biotechnology, Elsevier 237-250.  
01-01-2011
5.03 Biofluids: Microcirculation
Lu Y, Wang W
In Comprehensive Biotechnology, Elsevier 32-46.  
01-01-2011

2010

Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations
Bai K, Huang Y, Jia X, Fan Y, Wang W
Journal of Biomechanics vol. 43 (6), 1176-1181.  
01-04-2010
Multiscale modeling of fluid and solute transport in soft tissues and microvessels
Lu Y, Wang W
Journal of Multiscale Modeling vol. 2 (1-2), 127-145.  
01-03-2010
A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles
Ye S, Maeda E, Knight M, Lee D, Bader D, Wang W
Faseb Journal vol. 24 
01-01-2010
1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)
Maeda E, Ye S, Knight M, Wang W, Bader D, Lee D
Seibutsu Butsuri, Biophysical Society of Japan vol. 50 (supplement2) 
01-01-2010

2009

Growth factors enhance endothelial progenitor cell proliferation under high-glucose conditions
Li W, Yang SYY, Hu ZF, Winslet MC, Wang W, Seifalian AM
Med Sci Monitor vol. 15 (12), BR357-BR363.  
01-12-2009
Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system
Campbell JJ, Maeda E, Ye SJ, Wang W, Lee DA
European Cells and Materials vol. 18 (SUPPL. 2) 
01-07-2009
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow
Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W et al.
Proceedings of The National Academy of Sciences of The United States of America vol. 106 (20), 8326-8331.  
19-05-2009
Dynamic responses of shear flows over a deformable porous surface layer in a cylindrical tube
Wen PH, Hon YC, Wang W
Appl Math Model vol. 33 (1), 423-436.  
01-01-2009

2008

Rheological effects of blood in a nonplanar distal end-to-side anastomosis
Wang QQ, Ping BH, Xu QB, Wang W
Journal of Biomechanical Engineering vol. 130 (5) 
01-10-2008
Interaction between the interstitial fluid and the extracellular matrix in confined indentation
Lu Y, Wang W
Journal of Biomechanical Engineering vol. 130 (4) 
01-08-2008
Interaction between micro-particles in Oseen flows by the method of fundamental solutions
Wang W, Wen PH
Eng Anal Bound Elem vol. 32 (4), 318-327.  
01-04-2008

2007

Change in properties of the glycocalyx affects the shear rate and stress distribution on endothelial cells
Wang W
J Biomech Eng-T Asme vol. 129 (3), 324-329.  
01-06-2007
Movement of a spherical cell in capillaries using a boundary element method
Wen PH, Aliabadi MH, Wang W
J Biomech vol. 40 (8), 1786-1793.  
01-01-2007

2006

Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells
Yin XK, Mayr M, Xiao QZ, Wang W, Xu QB
Proteomics vol. 6 (24), 6437-6446.  
01-12-2006
Characterization of a laminar flow cell for the prevention of biosensor fouling
Kyriacou G, Vadgama P, Wang W
Med Eng Phys vol. 28 (10), 989-998.  
01-12-2006
Laminar flow of micropolar fluid in rectangular microchannels
Ye SJ, Zhu KQ, Wang W
Acta Mech Sinica vol. 22 (5), 403-408.  
01-10-2006
Indices of electromyographic activity and the slow component of oxygen uptake kinetics during high-intensity knee-extension exercise in humans
Garland SW, Wang W, Ward SA
Eur J Appl Physiol vol. 97 (4), 413-423.  
01-07-2006
Effects of osmotic pressure in the extracellular matrix on tissue deformation
Lu Y, Parker KH, Wang W
Philos T R Soc A vol. 364 (1843), 1407-1422.  
15-06-2006
Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses.
Chen J, Lu X-Y, Wang W
J Biomech vol. 39 (11), 1983-1995.  
01-01-2006
Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses
Chen J, Lu XY, Wang W
J Biomech vol. 39 (11), 1983-1995.  
01-01-2006
In vitro measurement of local oxygen partial pressures in chondrocyte-agarose constructs
Li W, Bader DL, Wang W
 
01-01-2006

2005

Modelling the concentration polarisation of hyaluronan on the surface of the synovial lining of infused joints
Lu Y, Levick JR, Wang W
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 824-825.  
01-12-2005
Microelectrodes and biocompatible sensors for skin pO2 measurements
Wang W, Vadgama P
, 337-352.  
01-12-2005
The mechanism of synovial fluid retention in pressurized joint cavities
Lu Y, Levick JR, Wang W
Microcirculation vol. 12 (7), 581-595.  
01-10-2005
In vivo measurements and theoretical modelling of oxygen partial pressure in outer layers of human skin
Wang W
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Effects of cyclic loads on transport of fluid and solutes in cell seeded constructs
Lu Y, Wang W
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Concentration polarisation of hyaluronan on the synovial lining of infused joints
Lu YL, Levick JR, Wang W
 
04-03-2005
Oxygen partial pressure in outer layers of skin: Simulation using three-dimensional multilayered models
Wang W
Microcirculation vol. 12 (2), 195-207.  
01-03-2005
Proteomic dataset of Sca-1+ progenitor cells
WANG W, Yin XK, Xu QB, Wait R, Mayr U, Mayr M, Xiao QZ, Tarelli E
Proteomics vol. 5 (17), 4533-4545.  
01-01-2005

2004

Concentration polarization of hyaluronan on the surface of the synovial lining of infused joints
Lu Y, Levick JR, Wang W
J Physiol-London vol. 561 (2), 559-573.  
01-12-2004
O-2 microsensors for minimally invasive tissue monitoring
Wang W, Vadgama P
J Roy Soc Interface vol. 1 (1), 109-117.  
22-11-2004
Numerical Analysis of the non-Newtonian blood flow in the non-planar artery with bifurcation
WANG W, Zhuang LX, Chen J, Lu XY
Journal of Hydrodynamics, B 
01-01-2004
Solute transport in porous medium under external loads
Lu Y, Wang W
Proceedings of The Asme Heat Transfer Fluids Engineering Summer Conference 2004 Ht Fed 2004 vol. 4, 693-699.  
01-01-2004
Concentration polarisation of hyaluronan on the surface of the synovial lining of infused joints
WANG W, Lu Y, Levick JR
Journal of Physiology 
01-01-2004
O2 microsensors for minimally invasive tissue monitoring
VADGAMA PM, Wang W
J.R. Soc. Interface vol. 1, 109-117.  
01-01-2004
Osmotic pressure of large molecules in extracellular matrix under dynamic loading conditions
Lu Y, Parker KH, Vadgama P, Bader DL, Wang W, Zhuang F, Li JC
 
01-01-2004
Interaction between fluid and solid i extracellular matrix
Bader DL, WANG W, Lu Y, Li ZY, Parker KH
Recent Advances in Fluid Mechanics, 679-682.  
01-01-2004
Interaction between fluid and solid in extracellular matrix
Li ZY, Lu YL, Parker KH, Bader DL, Wang W, Zhuang F, Li JC
 
01-01-2004

2003

Oxygen partial pressure in outer layers of skin of human finger nail folds
Wang W, Winlove CP, Michel CC
J Physiol-London vol. 549 (3), 855-863.  
15-06-2003

2002

A numerical study on oxygen transport by cutaneous microcirculation in outer layers of skin
Chen W, Lu XY, Zhuang LX, Wang W
Chinese Journal of Biomedical Engineering vol. 21 (6), 481-492.  
20-12-2002
Parallel-plate flow chamber for studies of 3D flow-endothelium interaction
Watkins NV, Caro CG, Wang W
Biorheology vol. 39 (3-4), 337-342.  
01-01-2002
Breaking symmetry in non-planar bifurcations: Distribution of flow and wall shear stress
Lu YL, Lu XY, Zhuang LX, Wang W
Biorheology vol. 39 (3-4), 431-436.  
01-01-2002
Breaking symmetry in a non-planar bifurcations: distribution of flow and wall shear stress
WANG W, Lu YL, Zhuang LX, Lu XY
Biorheology vol. 39, 431-436.  
01-01-2002
A numerical study on oxygen transport by cutaneous microcirculation in outer layers of skin
WANG W, Lu XY, Chen W, Zhuang LX
Journal of Biomedical Engineering vol. 21 (6), 216-228.  
01-01-2002

2001

Distribution of oxygen partial pressure in dermal papillae of human finger nailfolds
WANG W, Michel CC, Winlove CP
Journal of Vascular Research vol. 38 (4), 398-412.  
01-01-2001
exchange mechanism between microvessels and interstitium in the renal medulla
WANG W
Recent Advances in Biomechanics, 248-262.  
01-01-2001
Parallel-plate flow chamber for studies of 3D flow-endothelium interaction
WANG W, Caro CG, Watkins NV, Gao ZX
Journal of Physiology vol. 531P, 14-14.  
01-01-2001

2000

Modeling exchange of plasma proteins between microcirculation and interstitium of the renal medulla
Wang W, Michel CC
Am J Physiol-Renal vol. 279 (2), F334-F344.  
01-08-2000
A critical parameter for transcapillary exchange of small solutes in countercurrent systems
Wang W
J Biomech vol. 33 (5), 543-548.  
01-05-2000
Clearance of plasma proteins from the renal medulla
Wang W, Michel CC
Faseb J vol. 14 (4), A23-A23.  
15-03-2000

1999

A three-dimensional model on PO2 distribution in outer layers of human skin
Wang W, Michel CC, Winlove CP
J Vasc Res vol. 36 (4), 333-333.  
01-07-1999
Modelling PO2 distribution in outer layers of skin
Wang W, Michel CC, Winlove CP
Faseb J vol. 13 (4), A25-A25.  
12-03-1999

1998

Movement of spherical particles in capillaries using a boundary singularity method
Wang W, Parker KH
J Biomech vol. 31 (4), 347-354.  
01-04-1998

1997

Effects of anastomoses on salute transcapillary exchange in countercurrent systems
Wang W, Michel CC
Microcirculation-London vol. 4 (3), 381-390.  
01-01-1997

1996

CFD studies of separation of mists from gases using vane-type separators
Wang W, Davies GA
Chemical Engineering Research & Design vol. 74 (A2), 232-238.  
01-01-1996

1995

A SIMPLIFIED MATHEMATICAL-MODEL FOR THE TRANSCAPILLARY EXCHANGE OF FLUID AND ALBUMIN IN THE RENAL MEDULLA
WANG W, MICHEL CC
J Physiol-London vol. 483P, P139-P139.  
01-02-1995
THE EFFECT OF DEFORMABLE POROUS SURFACE-LAYERS ON THE MOTION OF A SPHERE IN A NARROW CYLINDRICAL TUBE
WANG W, PARKER KH
J Fluid Mech vol. 283, 287-305.  
25-01-1995
A theoretical study of transient cross-flow filtration using force balance analysis
Wang W, Jia X, Davies GA
Chemical Engineering Journal and The Biochemical Engineering Journal vol. 60 (1-3), 55-62.  
01-01-1995

1994

A MODEL FOR FLOW-THROUGH DISCONTINUITIES IN THE TIGHT JUNCTION OF THE ENDOTHELIAL INTERCELLULAR CLEFT
PHILLIPS CG, PARKER KH, WANG W
B Math Biol vol. 56 (4), 723-741.  
01-07-1994

1993

PATHWAYS THROUGH THE INTERCELLULAR CLEFTS OF FROG MESENTERIC CAPILLARIES
ADAMSON RH, MICHEL CC, PARKER KH, PHILLIPS CG, WANG W
J Physiol-London vol. 466, 303-327.  
01-07-1993

Human coronary artery tri-culture organ-chip recapitulates anti-inflammatory effect of pulsatile wall strain
Hou Y, Ziakas G, Hopkins T, Wang W, Screen HRC, Knight MM
In Biorxiv 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconEPSRC Core Equipment 2024
Wen Wang, Kshitij Sabnis, Andrei Sapelkin, Joseph Briscoe, Ian Sanders, James Busfield and Akram Alomainy
£849,082 Engineering and Physical Sciences Research Council
01-01-2025 - 30-06-2026
solid heart iconEpithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme 
Grant Summary

01-12-2023 - 30-11-2027

bullet iconEPSRC Core Equipment Award 2022
Wen Wang, Isabelle Mareschal, Massimo Poesio and Michael Reece
£875,000 EPSRC Engineering and Physical Sciences Research Council
03-01-2023 - 02-07-2024
bullet iconEPSRC Core Equipment 2020
Wen Wang, Ketao Zhang, Matteo Palma and Ildar Farkhatdinov
£497,496 Engineering and Physical Sciences Research Council
01-11-2020 - 30-04-2022
bullet iconNewton International Fellowship 2019: Dynamics of microcapsules in inertial two-phase flows-Dalei Jing
Wen Wang and Yi Sui
£103,316 Royal Society
01-03-2020 - 28-02-2022
bullet iconEPSRC Core Equipment Call
Wen Wang, Martin Knight, Clive Parini and Isaac Abrahams
£125,000 EPSRC Engineering and Physical Sciences Research Council
13-02-2020 - 12-08-2021
bullet iconPhD stipend and consumables for Mr S Feng
Wen Wang
£100,000 Zhoukou Tianjiukang Pharmaceutical Co. Ltd
01-01-2019 - 31-12-2022
bullet iconNPIF Doctoral Training Grant
Wen Wang
£34,664 EPSRC Engineering and Physical Sciences Research Council
01-10-2018 - 31-03-2020
bullet iconIndustrial PhD Award
Wen Wang
£100,000 Jinan Yucaoxuan Biotechnology Co. Ltd
01-09-2018 - 31-08-2022
bullet iconPhD Scholarship: Miss Xinqing Pang
Wen Wang
£60,000 ShijiazHuiran Software Technology
01-10-2017 - 30-09-2021
bullet iconPhD Scholarship: Mr Yuezhou Zhang
Wen Wang
£49,500 Wuxi Second Hospital
01-10-2017 - 30-09-2020
bullet iconPhD Scholarship in Complex Networks
Wen Wang
£80,000 Shenzhen Aoxinke Electronics Ltd
01-09-2016 - 30-09-2020
bullet iconPhD Scholarship in Vascular Bioengineering
Wen Wang
£60,000 Ju-Nail Technology Co Ltd
01-12-2015 - 30-11-2019
bullet iconMSMART
Wen Wang
£127,046 EU Commission - Horizon 2020
01-09-2015 - 31-08-2018