Prof Wen Wang

Wen Wang

Vice-Principal and Executive Dean

School of Engineering and Materials Science
Queen Mary University of London

Research

Cardiovascular Models

Interests

My work focuses on vascular bioengineering and biomaterial mechanics, including studies on the endothelial glycocalyx, vascular stem cells and progenator cells, transmembrane and transcapillary exchange. We are interested in developing in vitro models to study fundamental vascular mechanobiology and involvement in disease.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W and Xiao Q (2024). An Unexpected Role of IL10 in Mesoderm Induction and Differentiation from Pluripotent Stem Cells: Implications in Zebrafish Angiogenic Sprouting, Vascular Organoid Development, and Therapeutic Angiogenesis. Elsevier  European Journal of Cell Biology   
Jing D, Lu R, Farutin A, Guo Z, Wang F, Wang W, Misbah C and Sui Y (2024). Droplets can enhance microcapsule deformation in channel flow. Springer Nature  Communications Physics  vol. 7, (1)  
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT, Scarpa A, Wang W, Knight M, Loessner D, Heeschen C, Mata A and Pearce OMT (2024). A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer. Wiley  Advanced Healthcare Materials  vol. 13, (17)  
Xiao Y, Luo S, Qiu J, Zhang Y, Liu W, Zhao Y, Zhu Y, Deng Y, Lu M, Liu S, Lin Y, Huang A, Wang W, Hu X and Gu B (2024). Highly sensitive SERS platform for pathogen analysis by cyclic DNA nanostructure@AuNP tags and cascade primer exchange reaction. Springer Nature  Journal of Nanobiotechnology  vol. 22, (1)  

2023

Li W, Wang W, Luo S, Chen S, Ji T, Li N, Pan W, Zhang X, Wang X, Li K, Zhang Y and Yan X (2023). A sensitive and rapid electrochemical biosensor for sEV-miRNA detection based on domino-type localized catalytic hairpin assembly. Springer Nature  Journal of Nanobiotechnology  vol. 21, (1)  
Chen S, Cheng Y, Zhao Z, Zhang K, Hao T, Sui Y, Wang W, Zhao J and Li Y (2023). Core–Shell-Structured Electrorheological Fluid with a Polarizability-Tunable Nanocarbon Shell for Enhanced Stimuli-Responsive Activity. American Chemical Society (ACS)  ACS Applied Materials & Interfaces  vol. 15, (29) 35741-35749.  
Feng J, Jia L, Pan W, Fan Y, Guo J, Luo T, Liu C, Wang W, Zheng L and Li B (2023). Rapid and efficient fluorescent aptasensor for PD-L1 positive extracellular vesicles isolation and analysis: EV-ANCHOR. Elsevier  Chemical Engineering Journal  vol. 465,  
Guo Z, Lin T, Jing D, Wang W and Sui Y (2023). A method for real-time mechanical characterisation of microcapsules. Springer Nature  Biomechanics and Modeling in Mechanobiology  vol. 22, (4) 1209-1220.  
Wang Z, Lu R, Wang W, Tian FB, Feng JJ and Sui Y (2023). A computational model for the transit of a cancer cell through a constricted microchannel. Springer Nature  Biomechanics and Modeling in Mechanobiology  vol. 22, (4) 1129-1143.  
Zhang X, Jiang X, Wang W, Luo S, Guan S, Li W, Situ B, Li B, Zhang Y and Zheng L (2023). A simple and sensitive electrochemical biosensor for circulating tumor cell determination based on dual-toehold accelerated catalytic hairpin assembly. Springer Nature  Microchimica Acta  vol. 190, (2)  

2022

Zhang Y, Li W, Ji T, Luo S, Qiu J, Situ B, Li B, Zhang X, Zhang T, Wang W, Xiao Y, Zheng L and Yan X (2022). Localized DNA tetrahedrons assisted catalytic hairpin assembly for the rapid and sensitive profiling of small extracellular vesicle-associated microRNAs. Springer Nature  Journal of Nanobiotechnology  vol. 20, (1)  
Gao F, Yin J, Long Y, Zhu S, Huang Z, Wang J, Zheng H, Wang W and Zheng L (2022). [Retracted] Diagnostic Value of IGFBP‐2 in Predicting Preeclampsia before 20 Weeks of Pregnancy: A Prospective Nested Case‐Control Study. Hindawi  Computational and Mathematical Methods in Medicine  vol. 2022, (1)  
Jia L, Li B, Fang C, Liang X, Xie Y, Sun X, Wang W, Zheng L and Wang D (2022). Extracellular Vesicles of Mesenchymal Stem Cells Are More Effectively Accessed through Polyethylene Glycol‐Based Precipitation than by Ultracentrifugation. Hindawi  Stem Cells International  vol. 2022, (1)  
Wu Y, Yang J, van Teijlingen A, Berardo A, Corridori I, Feng J, Xu J, Titirici MM, Rodriguez-Cabello JC, Pugno NM, Sun J, Wang W, Tuttle T and Mata A (2022). Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma. Advanced Functional Materials   
Zhang Y, Hollis D, Ross R, Snow T, Terrill NJ, Lu Y, Wang W, Connelly J, Tozzi G and Gupta HS (2022). Investigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging. MDPI  Materials (Basel)  vol. 15, (5)  
T. Lin TL, Z. Wang ZW, R. X. Lu RXL, W. Wang WW and Y. Sui YS (2022). Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network. Global Science Press  Advances in Applied Mathematics and Mechanics  vol. 14, (1) 79-100.  

2021

Li W and Wang W (2021). The role of actomyosin in the regulation of syndecan-1 in hyperosmosis. Elsevier  BBA - General Subjects  vol. 1865, (10)  
Lu RX, Wang Z, Salsac A-V, Barthès-Biesel D, Wang W and Sui Y (2021). Path selection of a train of spherical capsules in a branched microchannel. Cambridge University Press (CUP)  Journal of Fluid Mechanics  vol. 923,  
Pu JH, Wang SK, Sun J, Wang W and Wang HS (2021). Growth and self-jumping of single condensed droplet on nanostructured surfaces: A molecular dynamics simulation. Elsevier  Journal of Molecular Liquids  vol. 340, 116902-116902.  
Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS (2021). Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. American Chemical Society  ACS Applied Materials and Interfaces  vol. 13, (22) 25792-25804.  
Wu Y, Fortunato GM, Okesola BO, Brocchetti FLPD, Suntornnond R, Connelly J, De Maria C, Rodriguez-Cabello JC, Vozzi G, Wang W and Mata A (2021). An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability. IOP Publishing  Biofabrication  vol. 13, (3)  
Pu JH, Wang SK, Sun J, Wang W and Wang HS (2021). Stable and Efficient Nanofilm Pure Evaporation on Nanopillar Surfaces. Langmuir  vol. 37, (12) 3731-3739.  
Guo T, Wang Y, Jia J, Mao X, Stankiewicz E, Scandura G, Burke E, Xu L, Marzec J, Davies CR, Lu JJ, Rajan P, Grey A, Tipples K, Hines J, Kudahetti S, Oliver T, Powles T, Alifrangis C, Kohli M, Shaw G, Wang W, Feng N, Shamash J, Berney D, Wang L and Lu Y-J (2021). The Identification of Plasma Exosomal miR-423-3p as a Potential Predictive Biomarker for Prostate Cancer Castration-Resistance Development by Plasma Exosomal miRNA Sequencing. Frontiers  Frontiers in Cell and Developmental Biology  vol. 8,  
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M (2021). Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction., Editors: Block JA. Elsevier  Osteoarthritis and Cartilage   
Lin T, Wang Z, Lu R, Wang W and Sui Y (2021). A high-throughput method to characterize membrane viscosity of flowing microcapsules. AIP Publishing  Physics of Fluids  vol. 33, (1)  
Lin T, Wang Z, Wang W and Sui Y (2021). A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules. Royal Society of Chemistry (RSC)  Soft Matter  vol. 17, (15) 4027-4039.  
Lin T, Wang Z, Wang W and Sui Y (2021). Correction: A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules. Royal Society of Chemistry (RSC)  Soft Matter  vol. 17, (15) 4213-4213.  
Pu JH, Sheng Q, Sun J, Wang W and Wang HS (2021). Molecular Dynamics Simulation of Effect of Temperature Difference on Surface Condensation. Advances in Heat Transfer and Thermal Engineering  Springer Nature   

2020

He S, Yang F, Yang M, An W, Maguire EM, Chen Q, Xiao R, Wu W, Zhang L, Wang W and Xiao Q (2020). miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia. Springer Nature  Stem Cell Research & Therapy  vol. 11, (1)  
Wu Y, Wang W, Mata A, Pugno N, Azevedo H, Karabasov S and Titirici M-M (2020). Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices. Nature Research (part of Springer Nature)  Nature Communications   
Pu JH, Sun J, Wang W and Wang HS (2020). Generation and Evolution of Nanobubbles on Heated Nanoparticles: A Molecular Dynamics Study. American Chemical Society  Langmuir: the ACS journal of surfaces and colloids  vol. 36, 2375-2382.  
Yang J, Moraga A, Xu J, Zhao Y, Luo P, Lao KH, Margariti A, Zhao Q, Ding W, Wang G, Zhang M, Zheng L, Zhang Z, Hu Y, Wang W, Shen L, Smith A, Shah AM, Wang Q and Zeng L (2020). A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3γ phosphorylation. Oxford University Press (OUP)  Stem Cells  vol. 38, (4) 556-573.  
Fan B, Wang W, Wang T, Xie B, Zhang H, Liao Y, Lu C and Guo L (2020). Problematic Internet Use, Non-Medical Use of Prescription Drugs, and Depressive Symptoms among Adolescents: A Large-Scale Study in China. MDPI  International Journal of Environmental Research and Public Health  vol. 17, (3)  

2019

Pu JH, Sun J, Sheng Q, Wang W and Wang HS (2019). Dependences of Formation and Transition of the Surface Condensation Mode on Wettability and Temperature Difference. American Chemical Society  Langmuir: the ACS journal of surfaces and colloids  vol. 36, 456-464.  
Arokiasamy S, King R, Boulaghrasse H, Poston R, Nourshargh S, Wang W and Voisin M-B (2019). Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo. Frontiers Media  Frontiers in Immunology   
Li W and Wang W (2019). Membrane tension regulates syndecan-1 expression through actin remodelling. Biochim Biophys Acta Gen Subj  vol. 1863, (11) 129413-129413.  
Pang X, Li W, Landwehr E, Yuan Y, Wang W and Azevedo HS (2019). Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces. Faraday Discuss   
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM (2019). Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Elsevier  Osteoarthritis and Cartilage  vol. 27, (7) 1064-1074.  
PU JH, SHENG Q, Sun J, WANG W and WANG H (2019). Dependence of nano-confined surface condensation on tangentially external force field. Elsevier  Journal of Molecular Liquids   
Wang F, Contò FP, Naz N, Castrejón-Pita JR, Castrejón-Pita AA, Bailey CG, Wang W, Feng JJ and Sui Y (2019). A fate-alternating transitional regime in contracting liquid filaments. Journal of Fluid Mechanics  vol. 860, 640-653.  
Lu Y and Wang W (2019). Biofluids: Microcirculation. Comprehensive Biotechnology  
Wang Z, Sui Y, Wang W, Barthѐs-Biesel D and Salsac A-V (2019). Path Selection of a Spherical Capsule in a Branched Channel. Tech Science Press  Molecular & Cellular Biomechanics  vol. 16, (S2) 42-43.  

2018

Peng J, Wang W, Zheng L, Guan Y, Ye G, Tong H, Wang Y and Wang Q (2018). Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy. Oxford University Press (OUP)  Lab Medicine  vol. 50, (2) 163-167.  
Tang P, di Cio S, Wang W and E Gautrot J (2018). Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes. Langmuir  vol. 34, (34) 10019-10027.  
ZHAO T, DENG L, WANG W, Elson D and SU L (2018). Bayes’ theorem based binary algorithm for fast reference-less calibration of a multimode fiber. Optical Society of America (OSA)  Optics Express   
Wang Z, Sui Y, Salsac AV, Barthès-Biesel D and Wang W (2018). Path selection of a spherical capsule in a microfluidic branched channel: Towards the design of an enrichment device. Journal of Fluid Mechanics  vol. 849, 136-162.  
Liu J, Zhang Y, Zhao Q, Situ B, Zhao J, Luo S, Li B, Yan X, Vadgama P, Su L, Ma W, Wang W and Zheng L (2018). Bifunctional aptamer-mediated catalytic hairpin assembly for the sensitive and homogenous detection of rare cancer cells. Anal Chim Acta  vol. 1029, 58-64.  
Yang J, Xu J, Danniel M, Wang X, Wang W, Zeng L and Shen L (2018). The interaction between XBP1 and eNOS contributes to endothelial cell migration. Elsevier  Experimental Cell Research  vol. 363, (2) 262-270.  
Zhao K, Zhao Q, Guo Z, Chen Z, Hu Y, Su J, Chen L, He Z, Cai X, Chen M, Zheng L, Wang W and Wang Q (2018). Hsa_Circ_0001275: A Potential Novel Diagnostic Biomarker for Postmenopausal Osteoporosis. Karger Publishers  Cellular Physiology and Biochemistry  vol. 46, (6) 2508-2516.  

2017

SHENG Q, SUN J, WANG W, WANG HS and BAILEY CG (2017). How solid surface free energy determines coalescence-induced nanodroplet jumping: A molecular dynamics investigation. AIP Publishing  Journal of Applied Physics  vol. 122, 245301 (2017),  
Hughes-Brittain NF, Qiu L, Wang W, Peijs T and Bastiaansen CWM (2017). Degradation and biocompatibility of photoembossed PLGA-acrylate blend for improved cell adhesion. J Biomed Mater Res B Appl Biomater  vol. 106, (1) 163-171.  
Norton R, Honarbakshs S, Wang W, Schilling R and Hunter R (2017). 118A novel method to determine left atrial compliance in vivo: relationship with markers of remodelling in AF. Oxford University Press (OUP)  EP Europace  vol. 19, (suppl_1) i49-i49.  
WANG W (2017). Effects of High Pressure on Phospholipid Bilayers. American Chemical Society  Journal of Physical Chemistry B   
Li W and Wang W (2017). Structural alteration of the endothelial glycocalyx: contribution of the actin cytoskeleton. Biomech Model Mechanobiol   
Hughes-Brittain NF, Qiu L, Picot OT, Wang W, Peijs T and Bastiaansen CWM (2017). Surface texturing of electrospun fibres by photoembossing using pulsed laser interference holography and its effects on endothelial cell adhesion. Polymer (United Kingdom)  vol. 125, 40-49.  
Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, Barco Barrantes ID, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A and Xu Q (2017). A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective. Circulation  vol. 136, (11) 1022-1036.  
VOISIN M (2017). Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. Nature Publishing Group  Scientific Reports   

2016

Qiu L, Hughes-Brittain NF, Bastiaansen CWM, Peijs T and Wang W (2016). Responses of Vascular Endothelial Cells to Photoembossed Topographies on Poly(Methyl Methacrylate) Films. J Funct Biomater  vol. 7, (4)  
Wang Z, Sui Y, Salsac AV, Barthès-Biesel D and Wang W (2016). Motion of a spherical capsule in branched tube flow with finite inertia. Journal of Fluid Mechanics  vol. 806, 603-626.  
Mo J, Prévost SF, Blowes LM, Egertová M, Terrill NJ, Wang W, Elphick MR and Gupta HS (2016). Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale. Proc Natl Acad Sci U S A   
Sheng Q, Sun J, Wang Q, Wang W and Wang HS (2016). On the onset of surface condensation: Formation and transition mechanisms of condensation mode. Nature Publishing Group: Open Access Journals - Option C  Scientific Reports   
Yu B, Wong MM, Potter CMF, Simpson RML, Karamariti E, Zhang Z, Zeng L, Warren D, Hu Y, Wang W and Xu Q (2016). Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation. Wiley  Stem Cells  vol. 34, (9) 2368-2380.  
Lv W, Zhao J, Situ B, Li B, Ma W, Liu J, Wu Z, Wang W, Yan X and Zheng L (2016). A target-triggered dual amplification strategy for sensitive detection of microRNA. Biosensors and Bioelectronics   
KNIGHT MM, wang W, wang Z, wann A, thompson C and hassen A (2016). IFT88 influences chondrocyte actin organization and biomechanics. Osteoarthritis and Cartilage   

2015

Ma W, Situ B, Lv W, Li B, Yin X, Vadgama P, Zheng L and Wang W (2015). Electrochemical determination of microRNAs based on isothermal strand-displacement polymerase reaction coupled with multienzyme functionalized magnetic micro-carriers. Biosensors and Bioelectronics  vol. 80, 344-351.  
Ding W, Palaiokostas M, Wang W and Orsi M (2015). Effects of Lipid Composition on Bilayer Membranes Quantified by All-Atom Molecular Dynamics. American Chemical Society (ACS)  The Journal of Physical Chemistry B  vol. 119, (49) 15263-15274.  
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y and Xu Q (2015). XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 35, (10) 2134-2144.  
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J, Ye S, Xu Q, Wang W and Xiao Q (2015). Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Cell Death and Differentiation  vol. 22, (7) 1170-1180.  
Wang X, Karamariti E, Simpson R, Wang W and Xu Q (2015). Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling*. Elsevier  Journal of Biological Chemistry  vol. 290, (32) 19844-19852.  
Yang J, Zeng L, Wang W and Li Y (2015). Abstract 662: X-box Binding Protein 1 Splicing Promotes Wound Healing via Modulating Endothelial Nitric Oxide Synthase. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 35, (suppl_1)  
Yu B, Wong MM, Wang W, Hu Y and Xu Q (2015). Abstract 200: Vascular Stem Cell Migration in Response to Monocyte Chemoattractant Protein-1 Promotes Neointima Lesion Formation. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 35, (suppl_1)  
Yu B, Wong MM, Potter C, Hu Y, Wang W and Xu Q (2015). Abstract 9: Smooth Muscle Cells Are Crucial for Vascular Stem Cell Migration and Vasculogenesis via Keratinocyte Cell-derived Chemokine. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 35, (suppl_1)  
Yang J-Y, Wang Q, Wang W and Zeng L-F (2015). Histone deacetylases and cardiovascular cell lineage commitment. Baishideng Publishing Group  World Journal of Stem Cells  vol. 7, (5) 852-858.  

2014

Liu W, Wang X, Bai K, Lin M, Sukhorukov G and Wang W (2014). Microcapsules functionalized with neuraminidase can enter vascular endothelial cells in vitro. J R Soc Interface  vol. 11, (101)  
Wang Z, Irianto J, Kazun S, Wang W and Knight MM (2014). The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes. Elsevier  Osteoarthritis and Cartilage  vol. 23, (2) 289-299.  
Deo DI, Gautrot JE, Sukhorukov GB and Wang W (2014). Biofunctionalization of PEGylated microcapsules for exclusive binding to protein substrates. Biomacromolecules  vol. 15, (7) 2555-2562.  
Sun J, Wang W and Wang HS (2014). Viscous dissipation effect in nano-confined shear flows: a comparative study between molecular dynamics and multi-scale hybrid simulations. Springer Link  Microfluidics and Nanofluidics   
Hughes-Brittain NF, Qiu L, Wang W, Peijs T and Bastiaansen CWM (2014). Photoembossing of surface relief structures in polymer films for biomedical applications. J Biomed Mater Res B Appl Biomater  vol. 102, (2) 214-220.  
Bai K and Wang W (2014). Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro. Biomechanics and Modeling in Mechanobiology  vol. 13, (2) 303-311.  
Lu$y.lu@derby.ac.uk$School of Engineering and Technology Y, University of Derby , Derby , Science UW-QLSOEAM, Mary , University of London , London , Oraifige$School of Engineering and Technology UI and Science UWWSOEAM (2014). Converging Parallel Plate Flow Chambers for Studies on the Effect of the Spatial Gradient of Wall Shear Stress on Endothelial Cells. Scientific Research Publishing  Journal of Biosciences and Medicines  vol. 02, (02) 50-56.  

2013

Wang Z, Sui Y, Spelt PDM and Wang W (2013). Three-dimensional dynamics of oblate and prolate capsules in shear flow. American Physical Society  Physical Review E: Statistical, Nonlinear, and Soft Matter Physics  vol. 88,  
Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z, Yin X, Mayr M, Cockerill G, Li JY-S, Chien S, Hu Y and Xu Q (2013). Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2. J Biol Chem  vol. 288, (44) 31853-31866.  
Luo Z, Wen G, Wang G, Pu X, Ye S, Xu Q, Wang W and Xiao Q (2013). MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1. Stem Cells  vol. 31, (9) 1749-1762.  
Ye S, Wang W and Shao X (2013). Numerical simulation of the hydrodynamics of endothelial glycocalyx under shear flow. IEEE International Conference on Control and Automation, ICCA  923-928.  
Zhao H, Huang Y, Yu X, Wen G, Wang W, Ye S and Xiao Q (2013). Abstract 004: Microrna-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells By Targeting Methyl Cpg Binding Protein 2. Wolters Kluwer  Circulation Research  vol. 113, (suppl_1)  
Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J, Wang W, Cockerill G, Mori K, Yi-Shuan Li J, Chien S, Hu Y and Xu Q (2013). Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation  vol. 127, (16) 1712-1722.  
Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q and Zeng L (2013). XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. Journal of Biological Chemistry  vol. 288, (2) 859-872.  
Sun J, Wang W and Wang HS (2013). Dependence of nanoconfined liquid behavior on boundary and bulk factors. Physical Review E: Statistical, Nonlinear, and Soft Matter Physics  vol. 87,  
Sun J, Wang W and Wang HS (2013). Dependence between velocity slip and temperature jump in shear flows. American Institute of Physics  The Journal of Chemical Physics  vol. 138, (23)  
Bai K and Wang W (2013). Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro. Biomechanics and Modeling in Mechanobiology  1-9.  

2012

Bai K and Wang W (2012). Spatio-temporal development of the endothelial glycocalyx layer and its mechanical property in vitro. Journal of the Royal Society Interface  vol. 9, (74) 2290-2298.  
Lu Y, Michel CC and Wang W (2012). Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels. J Appl Physiol (1985)  vol. 113, (3) 487-497.  
Tsai TN, Kirton JP, Campagnolo P, Zhang L, Xiao Q, Zhang Z, Wang W, Hu Y and Xu Q (2012). Contribution of stem cells to neointimal formation of decellularized vessel grafts in a novel mouse model. American Journal of Pathology  vol. 181, (1) 362-373.  
Hunter RJ, Liu Y, Lu Y, Wang W and Schilling RJ (2012). Left atrial wall stress distribution and its relationship to electrophysiologic remodeling in persistent atrial fibrillation. Circulation: Arrhythmia and Electrophysiology  vol. 5, (2) 351-360.  
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology  vol. 11, (3-4) 439-447.  
Luo Z, Wen G, Wang G, Pu X, Wang W, Ye S, Xu Q and Xiao Q (2012). Microrna-200c and-150 Play a Role in Human Embryonic Stem Cell Differentiation Into Endothelial Cells and Blood Vessel Formation by Targeting Transcription Repressor Zebi. CIRCULATION  vol. 126, (21)  

2011

Luo Z, Xiao Q, Wang W and Xu Q (2011). DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TOWARDS THE ENDOTHELIAL LINEAGE INVOLVES MICRORNAS. HEART  vol. 97, (20) 4-4.  
Lu Y and Wang W (2011). Biofluids. Comprehensive Biotechnology, Second Edition  
Zheng L, Liu JZ, Hu YW, Zhong TY, Xiong SL, Wang W and Wang Q (2011). Simulated Microgravity, Erythroid Differentiation, and the Expression of Transcription Factor GATA-1 in CD34(+) Cells. AVIAT SPACE ENVIR MD  vol. 82, (5) 513-517.  
Vikhansky A and Wang W (2011). Taylor dispersion in finite-length capillaries. CHEM ENG SCI  vol. 66, (4) 642-649.  
Cohen RD, Brown CL, Nickols C, Levey P, Boucher BJ, Greenwald SE and Wang W (2011). Inbuilt mechanisms for overcoming functional problems inherent in hepatic microlobular structure. Comput Math Methods Med  vol. 2011,  
Luo ZL, Wang G, Wang W, Xiao QZ and Xu QB (2011). Signalling pathways that regulate endothelial differentiation from stem cells. FRONT BIOSCI-LANDMRK  vol. 16, 472-485.  
Lu Y and Wang W (2011). 5.19 Biofluids | Microcirculation. Comprehensive Biotechnology  Elsevier   
Lu Y and Wang W (2011). 5.03 Biofluids: Microcirculation. Comprehensive Biotechnology  Elsevier   

2010

Bai K, Huang Y, Jia X, Fan Y and Wang W (2010). Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations. Journal of Biomechanics  vol. 43, (6) 1176-1181.  
Lu Y and Wang W (2010). Multiscale modeling of fluid and solute transport in soft tissues and microvessels. Journal of Multiscale Modeling  vol. 2, (1-2) 127-145.  
Ye S, Maeda E, Knight M, Lee D, Bader D and Wang W (2010). A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles. FASEB JOURNAL  vol. 24,  
Maeda E, Ye S, Knight M, Wang W, Bader D and Lee D (2010). 1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan). Biophysical Society of Japan  Seibutsu Butsuri  vol. 50, (supplement2)  

2009

Li W, Yang SYY, Hu ZF, Winslet MC, Wang W and Seifalian AM (2009). Growth factors enhance endothelial progenitor cell proliferation under high-glucose conditions. MED SCI MONITOR  vol. 15, (12) BR357-BR363.  
Campbell JJ, Maeda E, Ye SJ, Wang W and Lee DA (2009). Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system. European Cells and Materials  vol. 18, (SUPPL. 2)  
Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin ZG, Cockerill G, Mori K, Li YSJ, Hu Y, Chien S and Xu Q (2009). Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proceedings of the National Academy of Sciences of the United States of America  vol. 106, (20) 8326-8331.  
Wen PH, Hon YC and Wang W (2009). Dynamic responses of shear flows over a deformable porous surface layer in a cylindrical tube. APPL MATH MODEL  vol. 33, (1) 423-436.  

2008

Wang QQ, Ping BH, Xu QB and Wang W (2008). Rheological effects of blood in a nonplanar distal end-to-side anastomosis. Journal of Biomechanical Engineering  vol. 130, (5)  
Lu Y and Wang W (2008). Interaction between the interstitial fluid and the extracellular matrix in confined indentation. Journal of Biomechanical Engineering  vol. 130, (4)  
Wang W and Wen PH (2008). Interaction between micro-particles in Oseen flows by the method of fundamental solutions. ENG ANAL BOUND ELEM  vol. 32, (4) 318-327.  

2007

Wang W (2007). Change in properties of the glycocalyx affects the shear rate and stress distribution on endothelial cells. J BIOMECH ENG-T ASME  vol. 129, (3) 324-329.  
Wen PH, Aliabadi MH and Wang W (2007). Movement of a spherical cell in capillaries using a boundary element method. J BIOMECH  vol. 40, (8) 1786-1793.  

2006

Yin XK, Mayr M, Xiao QZ, Wang W and Xu QB (2006). Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells. PROTEOMICS  vol. 6, (24) 6437-6446.  
Kyriacou G, Vadgama P and Wang W (2006). Characterization of a laminar flow cell for the prevention of biosensor fouling. MED ENG PHYS  vol. 28, (10) 989-998.  
Ye SJ, Zhu KQ and Wang W (2006). Laminar flow of micropolar fluid in rectangular microchannels. ACTA MECH SINICA  vol. 22, (5) 403-408.  
Garland SW, Wang W and Ward SA (2006). Indices of electromyographic activity and the slow component of oxygen uptake kinetics during high-intensity knee-extension exercise in humans. EUR J APPL PHYSIOL  vol. 97, (4) 413-423.  
Lu Y, Parker KH and Wang W (2006). Effects of osmotic pressure in the extracellular matrix on tissue deformation. PHILOS T R SOC A  vol. 364, (1843) 1407-1422.  
Chen J, Lu X-Y and Wang W (2006). Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses. J Biomech  vol. 39, (11) 1983-1995.  
Chen J, Lu XY and Wang W (2006). Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses. J BIOMECH  vol. 39, (11) 1983-1995.  

2005

Lu Y, Levick JR and Wang W (2005). Modelling the concentration polarisation of hyaluronan on the surface of the synovial lining of infused joints. Proceedings of the 2005 Summer Bioengineering Conference  vol. 2005, 824-825.  
Wang W and Vadgama P (2005). Microelectrodes and biocompatible sensors for skin pO2 measurements. 
Lu Y, Levick JR and Wang W (2005). The mechanism of synovial fluid retention in pressurized joint cavities. MICROCIRCULATION  vol. 12, (7) 581-595.  
Wang W (2005). In vivo measurements and theoretical modelling of oxygen partial pressure in outer layers of human skin. European Cells and Materials  vol. 10, (SUPPL.2)  
Lu Y and Wang W (2005). Effects of cyclic loads on transport of fluid and solutes in cell seeded constructs. European Cells and Materials  vol. 10, (SUPPL.2)  
Wang W (2005). Oxygen partial pressure in outer layers of skin: Simulation using three-dimensional multilayered models. MICROCIRCULATION  vol. 12, (2) 195-207.  
WANG W, Yin XK, Xu QB, Wait R, Mayr U, Mayr M, Xiao QZ and Tarelli E (2005). Proteomic dataset of Sca-1+ progenitor cells. Proteomics  vol. 5, (17) 4533-4545.  

2004

Lu Y, Levick JR and Wang W (2004). Concentration polarization of hyaluronan on the surface of the synovial lining of infused joints. J PHYSIOL-LONDON  vol. 561, (2) 559-573.  
Wang W and Vadgama P (2004). O-2 microsensors for minimally invasive tissue monitoring. J ROY SOC INTERFACE  vol. 1, (1) 109-117.  
WANG W, Zhuang LX, Chen J and Lu XY (2004). Numerical Analysis of the non-Newtonian blood flow in the non-planar artery with bifurcation. Journal of Hydrodynamics, B   
Lu Y and Wang W (2004). Solute transport in porous medium under external loads. Proceedings of the ASME Heat Transfer/Fluids Engineering Summer Conference 2004, HT/FED 2004  vol. 4, 693-699.  
WANG W, Lu Y and Levick JR (2004). Concentration polarisation of hyaluronan on the surface of the synovial lining of infused joints. Journal of Physiology   
VADGAMA PM and Wang W (2004). O2 microsensors for minimally invasive tissue monitoring. J.R. Soc. Interface  vol. 1, 109-117.  
Bader DL, WANG W, Lu Y, Li ZY and Parker KH (2004). Interaction between fluid and solid i extracellular matrix. Recent Advances in Fluid Mechanics  679-682.  

2003

Wang W, Winlove CP and Michel CC (2003). Oxygen partial pressure in outer layers of skin of human finger nail folds. J PHYSIOL-LONDON  vol. 549, (3) 855-863.  

2002

Chen W, Lu XY, Zhuang LX and Wang W (2002). A numerical study on oxygen transport by cutaneous microcirculation in outer layers of skin. Chinese Journal of Biomedical Engineering  vol. 21, (6) 481-492.  
Watkins NV, Caro CG and Wang W (2002). Parallel-plate flow chamber for studies of 3D flow-endothelium interaction. BIORHEOLOGY  vol. 39, (3-4) 337-342.  
Lu YL, Lu XY, Zhuang LX and Wang W (2002). Breaking symmetry in non-planar bifurcations: Distribution of flow and wall shear stress. BIORHEOLOGY  vol. 39, (3-4) 431-436.  
WANG W, Lu YL, Zhuang LX and Lu XY (2002). Breaking symmetry in a non-planar bifurcations: distribution of flow and wall shear stress. Biorheology  vol. 39, 431-436.  
WANG W, Lu XY, Chen W and Zhuang LX (2002). A numerical study on oxygen transport by cutaneous microcirculation in outer layers of skin. Journal of Biomedical Engineering  vol. 21, (6) 216-228.  

2001

WANG W, Michel CC and Winlove CP (2001). Distribution of oxygen partial pressure in dermal papillae of human finger nailfolds. Journal of Vascular Research  vol. 38, (4) 398-412.  
WANG W (2001). exchange mechanism between microvessels and interstitium in the renal medulla. Recent Advances in Biomechanics  248-262.  
WANG W, Caro CG, Watkins NV and Gao ZX (2001). Parallel-plate flow chamber for studies of 3D flow-endothelium interaction. Journal of Physiology  vol. 531P, 14-14.  

2000

Wang W and Michel CC (2000). Modeling exchange of plasma proteins between microcirculation and interstitium of the renal medulla. AM J PHYSIOL-RENAL  vol. 279, (2) F334-F344.  
Wang W (2000). A critical parameter for transcapillary exchange of small solutes in countercurrent systems. J BIOMECH  vol. 33, (5) 543-548.  
Wang W and Michel CC (2000). Clearance of plasma proteins from the renal medulla. FASEB J  vol. 14, (4) A23-A23.  

1999

Wang W, Michel CC and Winlove CP (1999). A three-dimensional model on PO2 distribution in outer layers of human skin. J VASC RES  vol. 36, (4) 333-333.  
Wang W, Michel CC and Winlove CP (1999). Modelling PO2 distribution in outer layers of skin. FASEB J  vol. 13, (4) A25-A25.  

1998

Wang W and Parker KH (1998). Movement of spherical particles in capillaries using a boundary singularity method. J BIOMECH  vol. 31, (4) 347-354.  

1997

Wang W and Michel CC (1997). Effects of anastomoses on salute transcapillary exchange in countercurrent systems. MICROCIRCULATION-LONDON  vol. 4, (3) 381-390.  

1996

Wang W and Davies GA (1996). CFD studies of separation of mists from gases using vane-type separators. CHEMICAL ENGINEERING RESEARCH & DESIGN  vol. 74, (A2) 232-238.  

1995

WANG W and MICHEL CC (1995). A SIMPLIFIED MATHEMATICAL-MODEL FOR THE TRANSCAPILLARY EXCHANGE OF FLUID AND ALBUMIN IN THE RENAL MEDULLA. J PHYSIOL-LONDON  vol. 483P, P139-P139.  
WANG W and PARKER KH (1995). THE EFFECT OF DEFORMABLE POROUS SURFACE-LAYERS ON THE MOTION OF A SPHERE IN A NARROW CYLINDRICAL TUBE. J FLUID MECH  vol. 283, 287-305.  
Wang W, Jia X and Davies GA (1995). A theoretical study of transient cross-flow filtration using force balance analysis. The Chemical Engineering Journal and The Biochemical Engineering Journal  vol. 60, (1-3) 55-62.  

1994

PHILLIPS CG, PARKER KH and WANG W (1994). A MODEL FOR FLOW-THROUGH DISCONTINUITIES IN THE TIGHT JUNCTION OF THE ENDOTHELIAL INTERCELLULAR CLEFT. B MATH BIOL  vol. 56, (4) 723-741.  

1993

ADAMSON RH, MICHEL CC, PARKER KH, PHILLIPS CG and WANG W (1993). PATHWAYS THROUGH THE INTERCELLULAR CLEFTS OF FROG MESENTERIC CAPILLARIES. J PHYSIOL-LONDON  vol. 466, 303-327.  

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
solid heart iconEpithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body - MSCA-2022-DN Martin Knight
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme (01-12-2023 - 30-11-2027)


bullet iconEPSRC Core Equipment Award 2022
Wen Wang, Isabelle Mareschal, Massimo Poesio and Michael Reece
£875,000 EPSRC Engineering and Physical Sciences Research Council (03-01-2023 - 02-07-2024)
bullet iconEPSRC Core Equipment 2020
Wen Wang, Ketao Zhang, Matteo Palma and Ildar Farkhatdinov
£497,496 EPSRC Engineering and Physical Sciences Research Council (01-11-2020 - 30-04-2022)
bullet iconPhD Scholarship: Mr Yuezhou Zhang
Wen Wang
£49,500 Wuxi Second Hospital (01-10-2017 - 30-09-2020)