Prof Wen Wang

Wen Wang

Vice-Principal and Executive Dean

School of Engineering and Materials Science
Queen Mary University of London

Research

Cardiovascular Models

Interests

My work focuses on vascular bioengineering and biomaterial mechanics, including studies on the endothelial glycocalyx, vascular stem cells and progenator cells, transmembrane and transcapillary exchange. We are interested in developing in vitro models to study fundamental vascular mechanobiology and involvement in disease.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Hydrogel empowered extracellular vesicles isolation, detection, and delivery

Nano Today, Elsevier Bv vol. 64, 102817-102817.  
01-10-2025
Harnessing the therapeutic potential of bacterial extracellular vesicles via functional peptides

Interdisciplinary Medicine, Wiley vol. 3 (4) 
23-03-2025
Microfluidic SERS biosensor based on Au-semicoated photonic crystals for melanoma diagnosis

Biosensors and Bioelectronics, Elsevier Bv vol. 271, 116983-116983.  
01-03-2025
Delivery of small interfering RNA by hydrogen sulfide-releasing nanomotor for the treatment of Parkinson's disease

Journal of Controlled Release, Elsevier Bv vol. 377, 648-660.  
01-01-2025

2024

An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis

European Journal of Cell Biology, Elsevier Bv vol. 103 (4), 151465-151465.  
01-12-2024
Droplets can enhance microcapsule deformation in channel flow

Communications Physics, Springer Science and Business Media Llc vol. 7 (1) 
20-09-2024
A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer

Advanced Healthcare Materials, Wiley vol. 13 (17) 
22-03-2024
Highly sensitive SERS platform for pathogen analysis by cyclic DNA nanostructure@AuNP tags and cascade primer exchange reaction

Journal of Nanobiotechnology, Springer Science and Business Media Llc vol. 22 (1) 
26-02-2024

2023

A sensitive and rapid electrochemical biosensor for sEV-miRNA detection based on domino-type localized catalytic hairpin assembly

Journal of Nanobiotechnology, Springer Science and Business Media Llc vol. 21 (1) 
09-09-2023
Core–Shell-Structured Electrorheological Fluid with a Polarizability-Tunable Nanocarbon Shell for Enhanced Stimuli-Responsive Activity

Acs Applied Materials &Amp; Interfaces, American Chemical Society (Acs) vol. 15 (29), 35741-35749.  
14-07-2023
Rapid and efficient fluorescent aptasensor for PD-L1 positive extracellular vesicles isolation and analysis: EV-ANCHOR

Chemical Engineering Journal, Elsevier Bv vol. 465, 142811-142811.  
01-06-2023
A method for real-time mechanical characterisation of microcapsules

Biomechanics and Modeling in Mechanobiology, Springer Science and Business Media Llc vol. 22 (4), 1209-1220.  
24-03-2023
A computational model for the transit of a cancer cell through a constricted microchannel

Biomechanics and Modeling in Mechanobiology, Springer Science and Business Media Llc vol. 22 (4), 1129-1143.  
28-02-2023
A simple and sensitive electrochemical biosensor for circulating tumor cell determination based on dual-toehold accelerated catalytic hairpin assembly

Microchimica Acta, Springer Science and Business Media Llc vol. 190 (2) 
24-01-2023

2022

Localized DNA tetrahedrons assisted catalytic hairpin assembly for the rapid and sensitive profiling of small extracellular vesicle-associated microRNAs

Journal of Nanobiotechnology, Springer Science and Business Media Llc vol. 20 (1) 
01-12-2022
Diagnostic Value of IGFBP-2 in Predicting Preeclampsia before 20 Weeks of Pregnancy: A Prospective Nested Case-Control Study

Computational and Mathematical Methods in Medicine, Wiley vol. 2022, 1-8.  
28-09-2022
Extracellular Vesicles of Mesenchymal Stem Cells Are More Effectively Accessed through Polyethylene Glycol-Based Precipitation than by Ultracentrifugation

Stem Cells International, Wiley vol. 2022, 1-12.  
06-09-2022
Disinfector‐Assisted Low Temperature Reduced Graphene Oxide‐Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma

Advanced Functional Materials, Wiley vol. 32 (38) 
08-07-2022
Investigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging

Materials, Mdpi Ag vol. 15 (5), 1836-1836.  
01-03-2022
Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network

Advances in Applied Mathematics and Mechanics, Global Science Press vol. 14 (1), 79-100.  
01-01-2022

2021

Growth and self-jumping of single condensed droplet on nanostructured surfaces: A molecular dynamics simulation

Journal of Molecular Liquids, Elsevier Bv vol. 340, 116902-116902.  
01-10-2021
The role of actomyosin in the regulation of syndecan-1 in hyperosmosis

Biochimica Et Biophysica Acta (Bba) - General Subjects, Elsevier Bv vol. 1865 (10), 129975-129975.  
01-10-2021
Path selection of a train of spherical capsules in a branched microchannel

Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 923 
22-07-2021
Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion

Acs Applied Materials &Amp; Interfaces, American Chemical Society (Acs) vol. 13 (22), 25792-25804.  
26-05-2021
An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability

Biofabrication, Iop Publishing vol. 13 (3), 035027-035027.  
08-04-2021
Stable and Efficient Nanofilm Pure Evaporation on Nanopillar Surfaces

Langmuir, American Chemical Society (Acs) vol. 37 (12), 3731-3739.  
18-03-2021
The Identification of Plasma Exosomal miR-423-3p as a Potential Predictive Biomarker for Prostate Cancer Castration-Resistance Development by Plasma Exosomal miRNA Sequencing

Frontiers in Cell and Developmental Biology, Frontiers Media Sa vol. 8 
07-01-2021
Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction

Osteoarthritis and Cartilage, Elsevier Bv vol. 29 (1), 89-99.  
01-01-2021
A high-throughput method to characterize membrane viscosity of flowing microcapsules

Physics of Fluids, Aip Publishing vol. 33 (1) 
01-01-2021
A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules

Soft Matter, Royal Society of Chemistry (Rsc) vol. 17 (15), 4027-4039.  
01-01-2021
Correction: A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules

Soft Matter, Royal Society of Chemistry (Rsc) vol. 17 (15), 4213-4213.  
01-01-2021
Molecular Dynamics Simulation of Effect of Temperature Difference on Surface Condensation

In Advances in Heat Transfer and Thermal Engineering, Springer Singapore 99-103.  
01-01-2021

2020

miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia

Stem Cell Research &Amp; Therapy, Springer Science and Business Media Llc vol. 11 (1) 
03-11-2020
Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices

Nature Communications, Springer Science and Business Media Llc vol. 11 (1) 
04-03-2020
Generation and Evolution of Nanobubbles on Heated Nanoparticles: A Molecular Dynamics Study

Langmuir, American Chemical Society (Acs) vol. 36 (9), 2375-2382.  
03-02-2020
A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3γ phosphorylation

Stem Cells, Oxford University Press (Oup) vol. 38 (4), 556-573.  
29-01-2020
Problematic Internet Use, Non-Medical Use of Prescription Drugs, and Depressive Symptoms among Adolescents: A Large-Scale Study in China

International Journal of Environmental Research and Public Health, Mdpi Ag vol. 17 (3), 774-774.  
26-01-2020

2019

Dependences of Formation and Transition of the Surface Condensation Mode on Wettability and Temperature Difference

Langmuir, American Chemical Society (Acs) vol. 36 (1), 456-464.  
15-12-2019
Membrane tension regulates syndecan-1 expression through actin remodelling

Biochimica Et Biophysica Acta (Bba) - General Subjects, Elsevier Bv vol. 1863 (11), 129413-129413.  
01-11-2019
Heparanase-Dependent Remodeling of Initial Lymphatic Glycocalyx Regulates Tissue-Fluid Drainage During Acute Inflammation in vivo

Frontiers in Immunology, Frontiers Media Sa vol. 10 
04-10-2019
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation

Osteoarthritis and Cartilage, Elsevier Bv vol. 27 (7), 1064-1074.  
01-07-2019
Dependence of nano-confined surface condensation on tangentially external force field

Journal of Molecular Liquids, Elsevier Bv vol. 283, 440-450.  
01-06-2019
Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces

Faraday Discussions, Royal Society of Chemistry (Rsc) vol. 219, 168-182.  
01-01-2019
Path Selection of a Spherical Capsule in a Branched Channel

Molecular &Amp; Cellular Biomechanics, Tech Science Press vol. 16 (S2), 42-43.  
01-01-2019

2018

A fate-alternating transitional regime in contracting liquid filaments

Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 860, 640-653.  
10-12-2018
Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy

Laboratory Medicine, Oxford University Press (Oup) vol. 50 (2), 163-167.  
04-12-2018
Bifunctional aptamer-mediated catalytic hairpin assembly for the sensitive and homogenous detection of rare cancer cells

Analytica Chimica Acta, Elsevier Bv vol. 1029, 58-64.  
01-10-2018
Bayes’ theorem-based binary algorithm for fast reference-less calibration of a multimode fiber

Optics Express, Optica Publishing Group vol. 26 (16), 20368-20368.  
26-07-2018
Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes

Langmuir, American Chemical Society (Acs) vol. 34 (34), 10019-10027.  
21-07-2018
Path selection of a spherical capsule in a microfluidic branched channel: towards the design of an enrichment device

Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 849, 136-162.  
18-06-2018
The interaction between XBP1 and eNOS contributes to endothelial cell migration

Experimental Cell Research, Elsevier Bv vol. 363 (2), 262-270.  
01-02-2018
DETECTION OF LIQUID-VAPOUR INTERFACE IN MOLECULAR DYNAMICS SIMULATION

International Heat Transfer Conference 16 10 Aug 2018 - 15 Aug 2018. 
01-01-2018
Hsa_Circ_0001275: A Potential Novel Diagnostic Biomarker for Postmenopausal Osteoporosis

Cellular Physiology and Biochemistry, S. Karger Ag vol. 46 (6), 2508-2516.  
01-01-2018

2017

How solid surface free energy determines coalescence-induced nanodroplet jumping: A molecular dynamics investigation

Journal of Applied Physics, Aip Publishing vol. 122 (24) 
27-12-2017
Effects of High Pressure on Phospholipid Bilayers

The Journal of Physical Chemistry B, American Chemical Society (Acs) vol. 121 (41), 9597-9606.  
05-10-2017
118A novel method to determine left atrial compliance in vivo: relationship with markers of remodelling in AF

Ep Europace, Oxford University Press (Oup) vol. 19 (suppl_1), i49-i49.  
01-10-2017
A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective

Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 136 (11), 1022-1036.  
12-09-2017
Surface texturing of electrospun fibres by photoembossing using pulsed laser interference holography and its effects on endothelial cell adhesion

Polymer, Elsevier Bv vol. 125, 40-49.  
01-09-2017
Structural alteration of the endothelial glycocalyx: contribution of the actin cytoskeleton

Biomechanics and Modeling in Mechanobiology, Springer Science and Business Media Llc vol. 17 (1), 147-158.  
14-08-2017
Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation

Scientific Reports, Springer Science and Business Media Llc vol. 7 (1) 
13-03-2017
Characterisation of the lymphatic endothelium glycocalyx and its regulation during acute inflammation in vivo

 
01-01-2017

2016

Responses of Vascular Endothelial Cells to Photoembossed Topographies on Poly(Methyl Methacrylate) Films

Journal of Functional Biomaterials, Mdpi Ag vol. 7 (4), 33-33.  
09-12-2016
Degradation and biocompatibility of photoembossed PLGA–acrylate blend for improved cell adhesion

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley vol. 106 (1), 163-171.  
02-12-2016
Motion of a spherical capsule in branched tube flow with finite inertia

Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 806, 603-626.  
13-10-2016
Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale

Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 113 (42) 
05-10-2016
A target-triggered dual amplification strategy for sensitive detection of microRNA

Biosensors and Bioelectronics, Elsevier Bv vol. 83, 250-255.  
01-09-2016
On the onset of surface condensation: formation and transition mechanisms of condensation mode

Scientific Reports, Springer Science and Business Media Llc vol. 6 (1) 
02-08-2016
Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation

Stem Cells, Oxford University Press (Oup) vol. 34 (9), 2368-2380.  
28-06-2016
Electrochemical determination of microRNAs based on isothermal strand-displacement polymerase reaction coupled with multienzyme functionalized magnetic micro-carriers

Biosensors and Bioelectronics, Elsevier Bv vol. 80, 344-351.  
01-06-2016
IFT88 influences chondrocyte actin organization and biomechanics

Osteoarthritis and Cartilage, Elsevier Bv vol. 24 (3), 544-554.  
01-03-2016
Molecular Simulation of Lipids and Water: Atomistic, Coarse-Grained, and Mixed Resolutions

 
01-02-2016
Atomistic and Coarse-Grained Molecular Simulations of Mixed Lamellar/Nonlamellar Lipid Membranes

 
01-02-2016

2015

Effects of Lipid Composition on Bilayer Membranes Quantified by All-Atom Molecular Dynamics

The Journal of Physical Chemistry B, American Chemical Society (Acs) vol. 119 (49), 15263-15274.  
24-11-2015
XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling

Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 35 (10), 2134-2144.  
01-10-2015
Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling

Journal of Biological Chemistry, Elsevier Bv vol. 290 (32), 19844-19852.  
01-08-2015
Abstract 662: X-box Binding Protein 1 Splicing Promotes Wound Healing via Modulating Endothelial Nitric Oxide Synthase

Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 35 (suppl_1) 
01-05-2015
Abstract 200: Vascular Stem Cell Migration in Response to Monocyte Chemoattractant Protein-1 Promotes Neointima Lesion Formation

Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 35 (suppl_1) 
01-05-2015
Abstract 9: Smooth Muscle Cells Are Crucial for Vascular Stem Cell Migration and Vasculogenesis via Keratinocyte Cell-derived Chemokine

Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 35 (suppl_1) 
01-05-2015
The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes

Osteoarthritis and Cartilage, Elsevier Bv vol. 23 (2), 289-299.  
01-02-2015
Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

Cell Death and Differentiation vol. 22 (7), 1170-1180.  
01-01-2015
Histone deacetylases and cardiovascular cell lineage commitment

World Journal of Stem Cells, Baishideng Publishing Group Inc. vol. 7 (5), 852-852.  
01-01-2015

2014

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells

Cell Death &Amp; Differentiation, Springer Science and Business Media Llc vol. 22 (7), 1170-1180.  
19-12-2014
Microcapsules functionalized with neuraminidase can enter vascular endothelial cells in vitro

Journal of The Royal Society Interface, The Royal Society vol. 11 (101), 20141027-20141027.  
06-12-2014
Biofunctionalization of PEGylated Microcapsules for Exclusive Binding to Protein Substrates

Biomacromolecules, American Chemical Society (Acs) vol. 15 (7), 2555-2562.  
30-05-2014
Viscous dissipation effect in nano-confined shear flows: a comparative study between molecular dynamics and multi-scale hybrid simulations

Microfluidics and Nanofluidics, Springer Science and Business Media Llc vol. 18 (1), 103-109.  
16-05-2014
Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro

Biomechanics and Modeling in Mechanobiology vol. 13 (2), 303-311.  
01-01-2014
Converging Parallel Plate Flow Chambers for Studies on the Effect of the Spatial Gradient of Wall Shear Stress on Endothelial Cells

Journal of Biosciences and Medicines, Scientific Research Publishing, Inc. vol. 02 (02), 50-56.  
01-01-2014

2013

Three-dimensional dynamics of oblate and prolate capsules in shear flow

Physical Review E, American Physical Society (Aps) vol. 88 (5) 
26-11-2013
Histone Deacetylase 3 Unconventional Splicing Mediates Endothelial-to-mesenchymal Transition through Transforming Growth Factor β2

Journal of Biological Chemistry, Elsevier Bv vol. 288 (44), 31853-31866.  
01-11-2013
MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1

Stem Cells, Oxford University Press (Oup) vol. 31 (9), 1749-1762.  
01-09-2013
Photoembossing of surface relief structures in polymer films for biomedical applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley vol. 102 (2), 214-220.  
02-08-2013
Abstract 004: Microrna-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells By Targeting Methyl Cpg Binding Protein 2

Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 113 (suppl_1) 
01-08-2013
Dependence between velocity slip and temperature jump in shear flows

The Journal of Chemical Physics, Aip Publishing vol. 138 (23) 
19-06-2013
Numerical simulation of the hydrodynamics of endothelial glycocalyx under shear flow

2013 10th Ieee International Conference On Control and Automation (Icca), Ieee, 923-928.  
01-06-2013
Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro

Biomechanics and Modeling in Mechanobiology, Springer Science and Business Media Llc vol. 13 (2), 303-311.  
29-05-2013
Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis

Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 127 (16), 1712-1722.  
23-04-2013
Dependence of nanoconfined liquid behavior on boundary and bulk factors

Physical Review E, American Physical Society (Aps) vol. 87 (2) 
26-02-2013
XBP1 mRNA Splicing Triggers an Autophagic Response in Endothelial Cells through BECLIN-1 Transcriptional Activation

Journal of Biological Chemistry, Elsevier Bv vol. 288 (2), 859-872.  
01-01-2013
MicroRNA-34a Regulated Sirtuin 1 is Required for Smooth Muscle Cell Differentiation From Murine and Human Embryonic Stem Cells

 
01-01-2013

2012

Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels

Journal of Applied Physiology, American Physiological Society vol. 113 (3), 487-497.  
01-08-2012
Contribution of Stem Cells to Neointimal Formation of Decellularized Vessel Grafts in a Novel Mouse Model

The American Journal of Pathology, Elsevier Bv vol. 181 (1), 362-373.  
01-07-2012
Left Atrial Wall Stress Distribution and Its Relationship to Electrophysiologic Remodeling in Persistent Atrial Fibrillation

Circulation: Arrhythmia and Electrophysiology, Ovid Technologies (Wolters Kluwer Health) vol. 5 (2), 351-360.  
01-04-2012
Spatio-temporal development of the endothelial glycocalyx layer and its mechanical property in vitro

Journal of The Royal Society Interface, The Royal Society vol. 9 (74), 2290-2298.  
14-03-2012
Microrna-200c and-150 Play a Role in Human Embryonic Stem Cell Differentiation Into Endothelial Cells and Blood Vessel Formation by Targeting Transcription Repressor Zebi

Circulation vol. 126 (21) 
01-01-2012

2011

6 Differentiation of human embryonic stem cells towards the endothelial lineage involves microRNAs

Heart, Bmj vol. 97 (20), e7-e7.  
23-09-2011
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading

Biomechanics and Modeling in Mechanobiology, Springer Science and Business Media Llc vol. 11 (3-4), 439-447.  
25-06-2011
Simulated Microgravity, Erythroid Differentiation, and the Expression of Transcription Factor GATA-1 in CD34<SUP>+</SUP> Cells

Aviation, Space, and Environmental Medicine, Aerospace Medical Association vol. 82 (5), 513-517.  
01-05-2011
Taylor dispersion in finite-length capillaries

Chemical Engineering Science, Elsevier Bv vol. 66 (4), 642-649.  
01-02-2011
Inbuilt Mechanisms for Overcoming Functional Problems Inherent in Hepatic Microlobular Structure

Comput Math Method M 
01-01-2011
Signalling pathways that regulate endothelial differentiation from stem cells

Frontiers in Bioscience, Imr Press vol. 16 (1), 472-472.  
01-01-2011
Biofluids | Microcirculation

In Comprehensive Biotechnology, Elsevier 237-250.  
01-01-2011
Biofluids: Microcirculation

In Comprehensive Biotechnology, Elsevier 32-46.  
01-01-2011
5.19 Biofluids | Microcirculation

In Comprehensive Biotechnology, Elsevier 237-250.  
01-01-2011
5.03 Biofluids: Microcirculation

In Comprehensive Biotechnology, Elsevier 32-46.  
01-01-2011

2010

Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations

J Biomech vol. 43 (6), 1176-1181.  
19-04-2010
A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles

The Faseb Journal, Wiley vol. 24 (S1) 
01-04-2010
MULTISCALE MODELING OF FLUID AND SOLUTE TRANSPORT IN SOFT TISSUES AND MICROVESSELS

Journal of Multiscale Modelling, World Scientific Pub Co Pte Ltd vol. 02 (01n02), 127-145.  
01-03-2010
1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri, Biophysical Society of Japan vol. 50 (supplement2), S79-S79.  
01-01-2010

2009

Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system

European Cells and Materials vol. 18 (SUPPL. 2) 
01-07-2009
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

P Natl Acad Sci Usa vol. 106 (20), 8326-8331.  
19-05-2009
Dynamic responses of shear flows over a deformable porous surface layer in a cylindrical tube

Applied Mathematical Modelling, Elsevier Bv vol. 33 (1), 423-436.  
01-01-2009
Growth factors enhance endothelial progenitor cell proliferation under high-glucose conditions

Medical Science Monitor vol. 15 (12), BR357-BR363.  
01-01-2009

2008

Rheological effects of blood in a nonplanar distal end-to-side anastomosis

J Biomech Eng-T Asme vol. 130 (5) 
01-10-2008
Interaction between the interstitial fluid and the extracellular matrix in confined indentation

J Biomech Eng-T Asme vol. 130 (4) 
01-08-2008
Interaction between micro-particles in Oseen flows by the method of fundamental solutions

Engineering Analysis With Boundary Elements, Elsevier Bv vol. 32 (4), 318-327.  
01-04-2008

2007

Movement of a spherical cell in capillaries using a boundary element method

Journal of Biomechanics, Elsevier Bv vol. 40 (8), 1786-1793.  
01-01-2007

2006

Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells

Proteomics, Wiley vol. 6 (24), 6437-6446.  
01-12-2006
Characterization of a laminar flow cell for the prevention of biosensor fouling

Medical Engineering &Amp; Physics, Elsevier Bv vol. 28 (10), 989-998.  
01-12-2006
Change in Properties of the Glycocalyx Affects the Shear Rate and Stress Distribution on Endothelial Cells

Journal of Biomechanical Engineering, Asme International vol. 129 (3), 324-329.  
04-11-2006
Laminar flow of micropolar fluid in rectangular microchannels

Acta Mechanica Sinica, Springer Science and Business Media Llc vol. 22 (5), 403-408.  
02-09-2006
Indices of electromyographic activity and the “slow” component of oxygen uptake kinetics during high-intensity knee-extension exercise in humans

European Journal of Applied Physiology, Springer Science and Business Media Llc vol. 97 (4), 413-423.  
10-05-2006
Effects of osmotic pressure in the extracellular matrix on tissue deformation

Philosophical Transactions of The Royal Society a: Mathematical, Physical and Engineering Sciences, The Royal Society vol. 364 (1843), 1407-1422.  
18-04-2006
Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses

Journal of Biomechanics, Elsevier Bv vol. 39 (11), 1983-1995.  
01-01-2006
In vitro measurement of local oxygen partial pressures in chondrocyte-agarose constructs

 
01-01-2006

2005

Modelling the concentration polarisation of hyaluronan on the surface of the synovial lining of infused joints

Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 824-825.  
01-12-2005
Proteomic dataset of Sca-1(+) progenitor cells

Proteomics vol. 5 (17), 4533-4545.  
01-11-2005
The Mechanism of Synovial Fluid Retention in Pressurized Joint Cavities

Microcirculation, Wiley vol. 12 (7), 581-595.  
11-10-2005
Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses.

Journal of Biomechanics vol. 39 (11), 1983-1995.  
01-08-2005
In vivo measurements and theoretical modelling of oxygen partial pressure in outer layers of human skin

European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Effects of cyclic loads on transport of fluid and solutes in cell seeded constructs

European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Oxygen Partial Pressure in Outer Layers of Skin: Simulation Using Three‐Dimensional Multilayered Models

Microcirculation, Wiley vol. 12 (2), 195-207.  
01-03-2005
Microelectrodes and Biocompatible Sensors for Skin pO2 Measurements

, Springer Berlin Heidelberg, 337-352.  
01-01-2005
Concentration polarisation of hyaluronan on the synovial lining of infused joints

 
01-01-2005

2004

Concentration polarization of hyaluronan on the surface of the synovial lining of infused joints

The Journal of Physiology, Wiley vol. 561 (2), 559-573.  
26-11-2004
O2microsensors for minimally invasive tissue monitoring

Journal of The Royal Society Interface, The Royal Society vol. 1 (1), 109-117.  
22-11-2004
NUMERICAL ANALYSIS OF THE NON-NEWTONIAN BLOOD FLOW IN THE NON-PLANAR ARTERY WITH BIFURCATION

Journal of Hydrodynamics vol. 16 (3), 248-253.  
01-01-2004
Solute Transport in Porous Medium Under External Loads

Volume 4, Asmedc, 693-699.  
01-01-2004
Osmotic pressure of large molecules in extracellular matrix under dynamic loading conditions

 
01-01-2004
Interaction between fluid and solid i extracellular matrix

Recent Advances in Fluid Mechanics, 679-682.  
01-01-2004
O2 microsensors for minimally invasive tissue monitoring

Journal of The Royal Society Interface vol. 1 (1), 109-117.  
01-01-2004
Interaction between fluid and solid in extracellular matrix

 
01-01-2004
Concentration polarization of hyaluronan on the surface of the synovial lining of infused joints

Journal of Physiology-London vol. 561 (2), 559-573.  
01-01-2004

2003

Oxygen Partial Pressure in Outer Layers of Skin of Human Finger Nail Folds

The Journal of Physiology, Wiley vol. 549 (3), 855-863.  
01-06-2003

2002

A numerical study on oxygen transport by cutaneous microcirculation in outer layers of skin

Chinese Journal of Biomedical Engineering vol. 21 (6), 481-492.  
20-12-2002
Parallel‐plate flow chamber for studies of 3D flow–endothelium interaction

Biorheology: The Official Journal of The International Society of Biorheology, Sage Publications vol. 39 (3-4), 337-342.  
01-05-2002
Breaking symmetry in non‐planar bifurcations: Distribution of flow and wall shear stress

Biorheology: The Official Journal of The International Society of Biorheology, Sage Publications vol. 39 (3-4), 431-436.  
01-05-2002
Breaking symmetry in a non-planar bifurcations: distribution of flow and wall shear stress

Biorheology vol. 39, 431-436.  
01-01-2002
A numerical study on oxygen transport by cutaneous microcirculation in outer layers of skin

Journal of Biomedical Engineering vol. 21 (6), 216-228.  
01-01-2002

2001

Distribution of oxygen partial pressure in dermal papillae of human finger nailfolds

Journal of Vascular Research vol. 38 (4), 398-412.  
01-01-2001
exchange mechanism between microvessels and interstitium in the renal medulla

Recent Advances in Biomechanics, 248-262.  
01-01-2001
Parallel-plate flow chamber for studies of 3D flow-endothelium interaction

Journal of Physiology vol. 531P, 14-14.  
01-01-2001

2000

Modeling exchange of plasma proteins between microcirculation and interstitium of the renal medulla

American Journal of Physiology-Renal Physiology, American Physiological Society vol. 279 (2), F334-F344.  
01-08-2000
A critical parameter for transcapillary exchange of small solutes in countercurrent systems

Journal of Biomechanics, Elsevier Bv vol. 33 (5), 543-548.  
01-05-2000
Clearance of plasma proteins from the renal medulla

Faseb Journal vol. 14 (4), A23-A23.  
01-01-2000

1999

Modelling PO2 distribution in outer layers of skin

Faseb Journal vol. 13 (4), A25-A25.  
01-01-1999
A three-dimensional model on PO2 distribution in outer layers of human skin

Journal of Vascular Research vol. 36 (4), 333-333.  
01-01-1999

1998

Movement of spherical particles in capillaries using a boundary singularity method

Journal of Biomechanics, Elsevier Bv vol. 31 (4), 347-354.  
01-04-1998

1997

Effects of Anastomoses on Solute Transcapillary Exchange in Countercurrent Systems

Microcirculation, Wiley vol. 4 (3), 381-390.  
01-09-1997

1996

CFD studies of separation of mists from gases using vane-type separators

Chemical Engineering Research and Design vol. 74 (2), 232-238.  
01-12-1996

1995

A theoretical study of transient cross-flow filtration using force balance analysis

The Chemical Engineering Journal and The Biochemical Engineering Journal, Elsevier Bv vol. 60 (1-3), 55-62.  
01-12-1995
The effect of deformable porous surface layers on the motion of a sphere in a narrow cylindrical tube

Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 283, 287-305.  
25-01-1995
A SIMPLIFIED MATHEMATICAL-MODEL FOR THE TRANSCAPILLARY EXCHANGE OF FLUID AND ALBUMIN IN THE RENAL MEDULLA

Journal of Physiology-London vol. 483P, P139-P139.  
01-01-1995

1994

A model for flow through discontinuities in the tight junction of the endothelial intercellular cleft

Bulletin of Mathematical Biology, Springer Science and Business Media Llc vol. 56 (4), 723-741.  
01-07-1994

1993

Pathways through the intercellular clefts of frog mesenteric capillaries.

The Journal of Physiology, Wiley vol. 466 (1), 303-327.  
01-07-1993

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconEPSRC Core Equipment 2024
Wen Wang, Kshitij Sabnis, Andrei Sapelkin, Joseph Briscoe and Ian Sanders
£449,082 EPSRC Engineering and Physical Sciences Research Council
01-01-2025 - 30-06-2026
solid heart iconEpithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme 
Grant Summary

01-12-2023 - 30-11-2027

bullet iconEPSRC Core Equipment Award 2022
Wen Wang, Isabelle Mareschal, Massimo Poesio and Michael Reece
£875,000 EPSRC Engineering and Physical Sciences Research Council
03-01-2023 - 02-07-2024
bullet iconEPSRC Core Equipment 2020
Wen Wang, Ketao Zhang, Matteo Palma and Ildar Farkhatdinov
£497,496 Engineering and Physical Sciences Research Council
01-11-2020 - 30-04-2022
bullet iconNewton International Fellowship 2019: Dynamics of microcapsules in inertial two-phase flows-Dalei Jing
Wen Wang and Yi Sui
£103,316 Royal Society
01-03-2020 - 28-02-2022
bullet iconEPSRC Core Equipment Call
Wen Wang, Martin Knight, Clive Parini and Isaac Abrahams
£125,000 EPSRC Engineering and Physical Sciences Research Council
13-02-2020 - 12-08-2021
bullet iconPhD stipend and consumables for Mr S Feng
Wen Wang
£100,000 Zhoukou Tianjiukang Pharmaceutical Co. Ltd
01-01-2019 - 31-12-2022
bullet iconNPIF Doctoral Training Grant
Wen Wang
£34,664 EPSRC Engineering and Physical Sciences Research Council
01-10-2018 - 31-03-2020
bullet iconIndustrial PhD Award
Wen Wang
£100,000 Jinan Yucaoxuan Biotechnology Co. Ltd
01-09-2018 - 31-08-2022
bullet iconPhD Scholarship: Miss Xinqing Pang
Wen Wang
£60,000 ShijiazHuiran Software Technology
01-10-2017 - 30-09-2021
bullet iconPhD Scholarship: Mr Yuezhou Zhang
Wen Wang
£49,500 Wuxi Second Hospital
01-10-2017 - 30-09-2020
bullet iconPhD Scholarship in Complex Networks
Wen Wang
£80,000 Shenzhen Aoxinke Electronics Ltd
01-09-2016 - 30-09-2020
bullet iconPhD Scholarship in Vascular Bioengineering
Wen Wang
£60,000 Ju-Nail Technology Co Ltd
01-12-2015 - 30-11-2019
bullet iconMSMART
Wen Wang
£127,046 EU Commission - Horizon 2020
01-09-2015 - 31-08-2018