Dr Oliver Pearce

Oliver Pearce

Reader in Tumour Extracellular Matrix

Centre for Tumour Microenvironment
Barts Cancer Institute

Research

Extracellular matrix, Immunity, decellularised tissue models

Cancer Models

Interests

We make decellularised models from human cancer tissues to explore how the tumour immune infiltrate is orientated and activated by the extracellular matrix. I run a service providing access to decellularised models and associated assays. www.matrixdynamics.co.uk

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Tyler EJ and Pearce OMT (2024). Tumor's Digest: Macrophage Metabolism Creates a Barrier to T Cells. American Association for Cancer Research (AACR)  Cancer Research  vol. 84, (20) 3322-3323.  
Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S, Alonge KM and Pearce OMT (2024). Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate. American Association for Cancer Research (AACR)  Cancer Research Communications  vol. 4, (4) 970-985.  
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT, Scarpa A, Wang W, Knight M, Loessner D, Heeschen C, Mata A and Pearce OMT (2024). A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer. Wiley  Advanced Healthcare Materials  vol. 13, (17)  

2023

Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM (2023). A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells. Wiley  Advanced Science  vol. 11, (2) 2305842-2305842.  
Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Dijke PT, Cameron AJ, Pearce O and Grose RP (2023). Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function. Wiley  The Journal of Pathology  vol. 262, (1) 90-104.  
Carter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, Dijke PT, Cameron A, Pearce O and Grose R (2023). Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function. Elsevier  Pancreatology  vol. 23, (4) e13-e14.  
Puttock EH, Tyler EJ, Manni M, Maniati E, Butterworth C, Burger Ramos M, Peerani E, Hirani P, Gauthier V, Liu Y, Maniscalco G, Rajeeve V, Cutillas P, Trevisan C, Pozzobon M, Lockley M, Rastrick J, Läubli H, White A and Pearce OMT (2023). Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis. Springer Nature  Nature Communications  vol. 14, (1)  
Hirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN and Pearce OM (2023). Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancer. American Association for Cancer Research (AACR)  Cancer Research  vol. 83, (7_Supplement) 5841-5841.  
Gauthier V, Tyler E, Liu Y, Sharp TV and Pearce OM (2023). Abstract 1339: Targeting specific extracellular matrix proteins to reactivate T cell trafficking in triple-negative breast cancer. American Association for Cancer Research (AACR)  Cancer Research  vol. 83, (7_Supplement) 1339-1339.  
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW (2023). Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK. MDPI  Cancers  vol. 15, (3)  

2022

Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM (2022). YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression. Elsevier  Osteoarthritis and Cartilage  vol. 31, (5) 600-612.  
Stanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J, Trefny MP, Monaco G, Bärenwaldt A, Gray MA, Petrone A, Kashyap AS, Glatz K, Kasenda B, Normington K, Broderick J, Peng L, Pearce OMT, Pearce EL, Bertozzi CR, Zippelius A and Läubli H (2022). Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade. American Association for the Advancement of Science (AAAS)  Science Translational Medicine  vol. 14, (669) eabj1270-eabj1270.  
Beatson R, Läubli H, Pearce OMT and Reis CA (2022). Editorial: Glycans: Masters of immunity, from cancers to inflammatory disease. Frontiers  Frontiers in Immunology  vol. 13,  
Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT (2022). Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models. MDPI  Biomolecules  vol. 12, (6)  
Malacrida B, Pearce OMT and Balkwill FR (2022). Building in vitro 3D human multicellular models of high-grade serous ovarian cancer. Elsevier  STAR Protocols  vol. 3, (1)  
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, Hodivala-Dilke K, Grose RP, Kocher HM, Gavara N, Pearce O, Cutillas P, Marshall JF and Cameron AJM (2022). Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion. Elsevier  Cell Reports  vol. 38, (4)  

2021

Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C, Novak M, McDermott J, Brenton JD, Cutillas PR, Rajeeve V, Hennino A, Drapkin R, Loessner D and Balkwill FR (2021). TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian CancerTGFBI and Ovarian Cancer. American Association for Cancer Research (AACR)  Cancer Research  vol. 81, (22) 5706-5719.  
Hirani P, Gauthier V, Allen CE, Wight TN and Pearce OMT (2021). Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer. Frontiers  Frontiers in Oncology  vol. 11,  
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM (2021). Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype. MDPI  Cancers  vol. 13, (12)  
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT (2021). A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. Elsevier  iScience  vol. 24, (6)  
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. Elsevier  iScience  vol. 24, (6)  
Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer., Editors: Balkwill F. biorxiv.org   
Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwängler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR and Clausen-Schaumann H (2021). Basement membrane stiffness determines metastases formation. Springer Nature  Nature Materials  vol. 20, (6) 892-903.  

2020

Pearce OMT and Läubli H (2020). A Sweet Approach to Heat Up Cancer Response to Immunotherapy. American Association for Cancer Research (AACR)  Cancer Discovery  vol. 10, (12) 1789-1790.  
Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OMT, Martineau Y, Pyronnet S, Bousquet C and Jean C (2020). FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer. EMBO MOLECULAR MEDICINE  vol. 12, (11)  
Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant‐Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OM, Martineau Y, Pyronnet S, Bousquet C and Jean C (2020). FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer. Springer Nature  EMBO Molecular Medicine  vol. 12, (11)  
Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE and Frevert CW (2020). Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation. Frontiers Media  Frontiers in Immunology  vol. 11,  
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joyce JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill F (2020). Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Elsevier BV  SSRN Electronic Journal   

2018

Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR and Hynes RO (2018). Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. Journal of Proteome Research  vol. 16, (8) 3083-3091.  
Pearce OMT and Läubli H (2018). Cancer Immunotherapy. Oxford University Press (OUP)  Glycobiology  vol. 28, (9) 638-639.  
Pearce OM (2018). Cancer glycan epitopes: biosynthesis, structure, and function. Glycobiology   

2017

Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov   
Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG and Varki A (2017). N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils. Proc Natl Acad Sci U S A  vol. 114, (39) E8155-E8164.  

2016

Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M and Balkwill FR (2016). A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases. American Association for Cancer Research  Clinical Cancer Research   
BALKWILL F, Anne Montfort and Oliver Pearce (2016). Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma. American Association for Cancer Research  Clinical Cancer Research   

2015

Pearce OMT and Läubli H (2015). Sialic acids in cancer biology and immunity. Oxford University Press (OUP)  Glycobiology  vol. 26, (2) 111-128.  
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Interleukin-6 Stimulates Defective Angiogenesis. American Association for Cancer Research (AACR)  Cancer Research  vol. 75, (15) 3098-3107.  
Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Abstract 4162: Interleukin–6 stimulates defective angiogenesis. American Association for Cancer Research (AACR)  Cancer Research  vol. 75, (15_Supplement) 4162-4162.  
Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OMT, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K and Sato C (2015). Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin*. Elsevier  Journal of Biological Chemistry  vol. 290, (21) 13202-13214.  
Pearce OMT, Samraj AN, Läubli H, Varki NM and Varki A (2015). Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 112, (12) e1405-e1405.  
Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, Varki A and Gagneux P (2015). Siglec receptors impact mammalian lifespan by modulating oxidative stress. eLife  eLife  vol. 4,  

2014

Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM and Varki A (2014). A red meat-derived glycan promotes inflammation and cancer progression. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 112, (2) 542-547.  
Läubli H, Pearce OMT, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD and Varki A (2014). Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 111, (39) 14211-14216.  
Pearce OM, Läubli H, Bui J and Varki A (2014). Hormesis in cancer immunology. Taylor & Francis  OncoImmunology  vol. 3, (6)  
Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD and Varki A (2014). Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies. Proceedings of the National Academy of Sciences  Proceedings of the National Academy of Sciences of the United States of America  vol. 111, (16) 5998-6003.  
Bergfeld A, Lawrence R, Diaz S, Pearce O, van Vleet J, Esko J, Choudhury B and Varki A (2014). Discovery of novel monosaccharides in animal glycans: natural occurrence of N‐glycolylhexosamines (607.6). Wiley  The FASEB Journal  vol. 28, (S1)  

2013

Buchlis G, Odorizzi P, Soto PC, Pearce OMT, Hui DJ, Jordan MS, Varki A, Wherry EJ and High KA (2013). Enhanced T Cell Function in a Mouse Model of Human Glycosylation. The American Association of Immunologists  The Journal of Immunology  vol. 191, (1) 228-237.  

2012

Bergfeld AK, Pearce OMT, Diaz SL, Pham T and Varki A (2012). Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID*. Elsevier  Journal of Biological Chemistry  vol. 287, (34) 28865-28881.  
Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R and Varki A (2012). Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups RESISTANCE OF α2–8-LINKED N-GLYCOLYLNEURAMINIC ACID TO ENZYMATIC CLEAVAGE*. Elsevier  Journal of Biological Chemistry  vol. 287, (34) 28917-28931.  
Bergfeld AK, Pearce OMT, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD and Varki A (2012). Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups INCORPORATION OF N-GLYCOLYLHEXOSAMINES INTO MAMMALIAN GLYCANS BY FEEDING N-GLYCOLYLGALACTOSAMINE*. Elsevier  Journal of Biological Chemistry  vol. 287, (34) 28898-28916.  
Davies L, Pearce O, Tessier M, Assar S, Smutova V, Pshezhetsky A, Woods R and Varki A (2012). Unusual chemical and enzymatic stability of polysialic acid containing N‐glycolylneuraminic acid. Wiley  The FASEB Journal  vol. 26, (S1) 610.1-610.1.  

2010

Buchlis G, Mingozzi F, Soto PC, Pearce O, Hui DJ, Varki AP and High KA (2010). Intrinsically Hyperactive and Hyperproliferative CD8+ T Cells In Cmah-/- Mice as a Model of Human Gene Transfer Responses. American Society of Hematology  Blood  vol. 116, (21)  
Pearce OMT and Varki A (2010). Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose. Elsevier  Carbohydrate Research  vol. 345, (9) 1225-1229.  

2005

Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG (2005). Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer. Wiley  Angewandte Chemie International Edition  vol. 44, (7) 1057-1061.  
Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG (2005). Titelbild: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. 7/2005). Wiley  Angewandte Chemie  vol. 117, (7) 1005-1005.  
Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG (2005). Cover Picture: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. Int. Ed. 7/2005). Wiley  Angewandte Chemie International Edition  vol. 44, (7) 983-983.  

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
solid heart iconOrgan-on-a-chip model of breast cancer bone metastases
and
£268,711 CR-UK Cancer Research UK (01-01-2021 - 30-06-2024)