Prof Julien Gautrot

Julien Gautrot

Professor of Biomaterials and Biointerfaces

School of Engineering and Materials Science
Queen Mary University of London
ResearcherID ORCID Google Scholar LinkedIn X

Research

Hydrogels, Microfabrication, 3D Printing, Mechanosensing, Microvascularisation, Bone marrow models

Underpinning Bioengineering, Cancer Models, Cardiovascular Models, Musculoskeletal Models, Neuronal Models, Skin Models

Interests

My lab is interested in the engineering of the cell microenvironment for advanced in vitro models and regenerative medicine applications. We design hydrogels with controlled biochemistry, mechanics, degradability and microstructure, allowing the regulation of stem cell phenotype (maintenance, differentiation, secretory phenotype). The biomaterials we engineer are also 3D printable and enable microfabrication (e.g. embedding in microfluidic chips or via photopatterning). We have a particular interest in microvascular models and their application to cancer, brain, cardiac and skin models, in collaboration with partners from the medical school.

Publications

Publications of specific relevance to Predictive in vitro Models

2024

Di Cio S, Marhuenda E, Haddrick M and Gautrot JE (2024). Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics. Springer Nature  Scientific Reports  vol. 14, (1) 10.1038/s41598-024-53678-w
Scemama A, Lunetto S, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2024). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. Faculty of 1000  F1000research  vol. 12, 10.12688/f1000research.131810.2

2023

Summan SK, Mayes A, Gunn D, Gautrot J, Caley M and O’Toole E (2023). P16 How does skin ageing-related basement membrane collagen loss affect the nucleus? Oxford University Press (Oup)  British Journal of Dermatology  vol. 189, (1) e20-e20. 10.1093/bjd/ljad174.037
Neri-Cruz CE, Teixeira FME and Gautrot JE (2023). A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes. Royal Society of Chemistry  Chemical Communications  vol. 59, (49) 7534-7558. 10.1039/d3cc01082a
Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M and O'Toole E (2023). 741 The effect of skin ageing-related basement membrane collagen loss on the nucleus. Elsevier  Journal of Investigative Dermatology  vol. 143, (5) s127-s127. 10.1016/j.jid.2023.03.750
Scemama A, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2023). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. Taylor and Francis  F1000research  vol. 12, 439-439. 10.12688/f1000research.131810.1
Cervantes-Salguero K, Gutiérrez Fosado YA, Megone W, Gautrot JE and Palma M (2023). Programmed Self-Assembly of DNA Nanosheets with Discrete Single-Molecule Thickness and Interfacial Mechanics: Design, Simulation, and Characterization. Mdpi  Molecules  vol. 28, (9) 10.3390/molecules28093686
Dibble M, Di Cio’ S, Luo P, Balkwill F and Gautrot JE (2023). The impact of pericytes on the stability of microvascular networks in response to nanoparticles. Springer Nature  Scientific Reports  vol. 13, (1) 10.1038/s41598-023-31352-x
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F (2023). Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer. American Association For Cancer Research (Aacr)  Cancer Research  vol. 83, (7_Supplement) 4576-4576. 10.1158/1538-7445.am2023-4576
Peng L, Nadal C and Gautrot JE (2023). Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oils. Iop Publishing  Biomedical Materials  vol. 18, (3) 10.1088/1748-605x/acbdda
Peng L, Matellan C, Bosch‐Fortea M, Gonzalez‐Molina J, Frigerio M, Salentinig S, del Rio Hernandez A and Gautrot JE (2023). Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces. Wiley  Advanced Healthcare Materials  vol. 12, (13) 10.1002/adhm.202203297
Nguyen KDQ, Dejean S, Nottelet B and Gautrot JE (2023). Mechanical Evaluation of Hydrogel–Elastomer Interfaces Generated through Thiol–Ene Coupling. American Chemical Society (Acs)  Acs Applied Polymer Materials  vol. 5, (2) 1364-1373. 10.1021/acsapm.2c01878
Chrysanthou A, Bosch-Fortea M and Gautrot JE (2023). Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilization of Bioemulsions Enabling Adherent Cell Expansion. American Chemical Society (Acs)  Biomacromolecules  vol. 24, (10) 4465-4477. 10.1021/acs.biomac.2c01289
Chrysanthou A, Kanso H, Zhong W, Shang L and Gautrot JE (2023). Supercharged Protein Nanosheets for Cell Expansion on Bioemulsions. American Chemical Society (Acs)  Acs Applied Materials & Interfaces  vol. 15, (2) 2760-2770. 10.1021/acsami.2c20188
Kaur A, Gautrot JE, Akutagawa K, Watson D, Bickley A and Busfield JJC (2023). Thiyl radical induced cis / trans isomerism in double bond containing elastomers. Royal Society of Chemistry (Rsc)  Rsc Advances  vol. 13, (34) 23967-23975. 10.1039/d3ra04157c

2022

Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2022). Kinetic analysis of thiol-ene based cross-linking reaction of polychloroprene rubber. Constitutive Models For Rubber Xii  Taylor & Francis  10.1201/9781003310266-38
Gautrot JE, Chang L, Alexis C, Gutfreund P and Zarbakhsh A (2022). The Architecture of Oligonucleotide-Polycationic Brush Complexes – A Neutron Reflectometry Study. Wiley  Advanced Materials Interfaces  10.1002/admi.202201344
Jones CFE, Di Cio S, Connelly JT and Gautrot JE (2022). Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model. Frontiers Media  Frontiers in Bioengineering and Biotechnology  vol. 10, 10.3389/fbioe.2022.915702
Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT (2022). Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models. Mdpi  Biomolecules  vol. 12, (6) 10.3390/biom12060837
Ghorbani S, Shahrokhtash A, Gautrot JE and Sutherland DS (2022). Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions. Wiley  Small Methods  vol. 6, (6) 10.1002/smtd.202200152
Kong D, Peng L, Bosch-Fortea M, Chrysanthou A, Alexis CVJM, Matellan C, Zarbakhsh A, Mastroianni G, del Rio Hernandez A and Gautrot JE (2022). Impact of the multiscale viscoelasticity of quasi-2D self-assembled protein networks on stem cell expansion at liquid interfaces. Elsevier  Biomaterials  vol. 284, 10.1016/j.biomaterials.2022.121494
Nguyen NT, Jennings J, Milani AH, Martino CDS, Nguyen LTB, Wu S, Mokhtar MZ, Saunders JM, Gautrot JE, Armes SP and Saunders BR (2022). Highly Stretchable Conductive Covalent Coacervate Gels for Electronic Skin. American Chemical Society (Acs)  Biomacromolecules  vol. 23, (3) 1423-1432. 10.1021/acs.biomac.1c01660

2021

Peng L and Gautrot JE (2021). Long term expansion profile of mesenchymal stromal cells at protein nanosheet-stabilised bioemulsions for next generation cell culture microcarriers. Elsevier  Materials Today Bio  vol. 12, 100159-100159. 10.1016/j.mtbio.2021.100159
Raynold AAM, Li D, Chang L and Gautrot JE (2021). Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors. Springer Nature  Nature Communications  vol. 12, (1) 10.1038/s41467-021-26695-w
Nguyen KDQ, Crespo-Ribadeneyra M, Picot O, Colak B and Gautrot JE (2021). Ultrafast Photo-Crosslinking of Thiol–Norbornene Opaque Silicone Elastomer Nanocomposites in Air. American Chemical Society  Acs Applied Polymer Materials  10.1021/acsapm.1c00440
Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2021). Novel Crosslinking System for Poly-Chloroprene Rubber to Enable Recyclability and Introduce Self-Healing. Mdpi  Polymers  vol. 13, (19) 10.3390/polym13193347
Megone W, Tang P, Roohpour N and Gautrot JE (2021). Impact of the molecular structure of cationic binders on the rheological and adhesive properties of carboxymethyl cellulose-based coacervate hydrogels. Arkat Usa  Arkivoc  vol. 2021, (6) 101-119. 10.24820/ark.5550190.p011.516
Chang L, Yan H, Chang J and Gautrot JE (2021). Cationic Polymer Brush-Coated Bioglass Nanoparticles for the Design of Bioresorbable RNA Delivery Vectors. Elsevier  European Polymer Journal  110593-110593. 10.1016/j.eurpolymj.2021.110593
Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS (2021). Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. American Chemical Society  Acs Applied Materials and Interfaces  vol. 13, (22) 25792-25804. 10.1021/acsami.1c05574
Megone W, Kong D, Peng L and Gautrot JE (2021). Extreme reversal in mechanical anisotropy in liquid-liquid interfaces reinforced with self-assembled protein nanosheets. Elsevier  Journal of Colloid and Interface Science  vol. 594, 650-657. 10.1016/j.jcis.2021.03.055
Qu F, Ma X and Gautrot JE (2021). Precise positioning of enzymes within hierarchical polymer nanostructures for switchable bioelectrocatalysis. Elsevier  Biosensors and Bioelectronics  vol. 179, 113045-113045. 10.1016/j.bios.2021.113045
Cozens EJ, Roohpour N and Gautrot JE (2021). Comparative Adhesion of Chemically and Physically Crosslinked Poly(Acrylic Acid)-Based Hydrogels to Soft Tissues. Elsevier  European Polymer Journal  110250-110250. 10.1016/j.eurpolymj.2020.110250
Qu F, Raynold AM and Gautrot JE (2021). Chapter 11 Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications. Soft Matter For Biomedical Applications  Royal Society of Chemistry (Rsc)  10.1039/9781839161124-00264

2020

Zhang X, Shi X, Gautrot JE and Peijs T (2020). Nanoengineered electrospun fibers and their biomedical applications: a review. Taylor & Francis  Nanocomposites  vol. 7, (1) 1-34. 10.1080/20550324.2020.1857121
You Y, Kobayashi K, Colak B, Luo P, Cozen E, Fields L, Suzuki K and Gautrot J (2020). Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair. Elsevier  Biomaterials  120356-120356. 10.1016/j.biomaterials.2020.120356
Li D, Xu L, Wang J and Gautrot JE (2020). Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics. Wiley  Advanced Healthcare Materials  10.1002/adhm.202000953
Wu L, Di Cio S, Azevedo HS and Gautrot JE (2020). Photoconfigurable, Cell-Remodelable Disulfide Cross-linked Hyaluronic Acid Hydrogels. American Chemical Society  Biomacromolecules  10.1021/acs.biomac.0c00603
Colak B, Wu L, Cozens EJ and Gautrot JE (2020). Modulation of Thiol-Ene Coupling by the Molecular Environment of Polymer Backbones for Hydrogel Formation and Cell Encapsulation. American Chemical Society  Acs Applied Bio Materials  10.1021/acsabm.0c00908
Zhang X, Megone W, Peijs T and Gautrot JE (2020). Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites. Taylor & Francis Group  Nanocomposites  10.1080/20550324.2020.1784600

2019

Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Elsevier  Biomaterials  vol. 232, 10.1016/j.biomaterials.2019.119683
Cozens EJ, Kong D, Roohpour N and Gautrot JE (2019). The physico-chemistry of adhesions of protein resistant and weak polyelectrolyte brushes to cells and tissues. Royal Society of Chemistry  Soft Matter  vol. 16, (2) 505-522. 10.1039/c9sm01403a
Li D, Wu L, Qu F, Ribadeneyra MC, Tu G and Gautrot J (2019). Core-independent approach for polymer brush-functionalised nanomaterials with a fluorescent tag for RNA delivery. Royal Society of Chemistry  Chemical Communications  vol. 55, (94) 14166-14169. 10.1039/c9cc05790k
Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Gautrot JE, Watkinson M, Becer CR and Krause S (2019). Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules  vol. 20, (7) 2506-2514. 10.1021/acs.biomac.9b00245
Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). Photo‐Responsive Graphene: A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites (Adv. Funct. Mater. 24/2019). Wiley  Advanced Functional Materials  vol. 29, (24) 10.1002/adfm.201970165
Qu F, Li D, Ma X, Chen F and Gautrot JE (2019). A Kinetic Model of Oligonucleotide–Brush Interactions for the Rational Design of Gene Delivery Vectors. American Chemical Society (Acs)  Biomacromolecules  vol. 20, (6) 2218-2229. 10.1021/acs.biomac.9b00155
Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites. Wiley  Advanced Functional Materials  vol. 29, (24) 10.1002/adfm.201900738
Ahmad N, Colak B, Zhang D-W, Gibbs MJ, Watkinson M, Becer CR, Gautrot JE and Krause S (2019). Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase. Mdpi  Sensors  vol. 19, (7) 10.3390/s19071677
GAUTROT JEE (2019). Conformational Dynamics and Responsiveness of Weak and Strong Polyelectrolyte Brushes: Atomistic Simulations of PDMAEMA and PMETAC. American Chemical Society  Langmuir  10.1021/acs.langmuir.8b04268
GAUTROT JEE (2019). Modes of adsorption of polyelectrolytes to model substrates of hydroxyapatite. Elsevier  Journal of Colloid and Interface Science  vol. 543, 237-237. 10.1016/j.jcis.2019.02.063

2018

Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M, Gautrot JE and Krause S (2018). Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films. Mdpi  10.3390/proceedings2130961
Kong D, Peng L, Di Cio S, Novak P and Gautrot JE (2018). Stem Cell Expansion and Fate Decision on Liquid Substrates Are Regulated by Self-Assembled Nanosheets. Acs Nano  vol. 12, (9) 9206-9213. 10.1021/acsnano.8b03865
Zhang X, Geven MA, Wang X, Qin L, Grijpma DW, Peijs T, Eglin D, Guillaume O and Gautrot JE (2018). A drug eluting poly(trimethylene carbonate)/poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules. Taylor & Francis  International Journal of Nanomedicine  vol. 13, 5701-5718. 10.2147/ijn.s163219
Tang P, di Cio S, Wang W and E Gautrot J (2018). Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes. Langmuir  vol. 34, (34) 10019-10027. 10.1021/acs.langmuir.8b01682
Zhang F, An Y, Roohpour N, Barber AH and Gautrot JE (2018). Hydration dependent mechanical performance of denture adhesive hydrogels. Elsevier  Dental Materials  vol. 34, (10) 1440-1448. 10.1016/j.dental.2018.06.015
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Elsevier  Developmental Cell  vol. 45, (5) 10.1016/j.devcel.2018.05.016
Megone W, Roohpour N and Gautrot JE (2018). Impact of surface adhesion and sample heterogeneity on the multiscale mechanical characterisation of soft biomaterials. Sci Rep  vol. 8, (1) 6780-6780. 10.1038/s41598-018-24671-x
Mata A, Azevedo HS, Connelly J and Gautrot J (2018). Bioengineering Complexity and Tuneability in Hydrogels. Hydrogels  Taylor & Francis  10.1201/9781315152226-17
Kong D, Megone W, Nguyen KDQ, Di Cio S, Ramstedt M and Gautrot JE (2018). Protein Nanosheet Mechanics Controls Cell Adhesion and Expansion on Low-Viscosity Liquids. Nano Lett  10.1021/acs.nanolett.7b05339
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell  vol. 44, (3) 326-336.e3. 10.1016/j.devcel.2017.12.024
Li D, Sharili AS, Connelly J and Gautrot JE (2018). Highly Stable RNA Capture by Dense Cationic Polymer Brushes for the Design of Cytocompatible, Serum-Stable SiRNA Delivery Vectors. Biomacromolecules  10.1021/acs.biomac.7b01686
Gill SK, Roohpour N, An Y, Gautrot JE, Topham PD and Tighe BJ (2018). Hydrophobic and hydrophilic effects on water structuring and adhesion in denture adhesives. Wiley  Journal of Biomedical Materials Research Part A  vol. 106, (5) 1355-1362. 10.1002/jbm.a.36341
Colak B, Di Cio S and Gautrot JE (2018). Biofunctionalised Patterned Polymer Brushes via Thiol-Ene Coupling for the Control of Cell Adhesion and the Formation of Cell Arrays. Biomacromolecules  10.1021/acs.biomac.7b01436

2017

Li D and Gautrot JE (2017). Design of Polymer Brushes for Cell Culture and Cellular Delivery. Polymer and Biopolymer Brushes  Wiley  10.1002/9781119455042.ch20
Krishnamoorthy M, Li D, Sharili AS, Gulin-Sarfraz T, Rosenholm JM and Gautrot JE (2017). The Solution Conformation of Polymer Brushes Determines their Interactions with DNA and Transfection Efficiency. Biomacromolecules  10.1021/acs.biomac.7b01175
Darshan GH, Kong D, Gautrot J and Vootla S (2017). Physico-chemical characterization of Antheraea mylitta silk mats for wound healing applications. Springer Nature  Scientific Reports  vol. 7, (1) 10.1038/s41598-017-10531-7
Zhang X, Geven MA, Grijpma D, Peijs T and Gautrot JE (2017). Tunable and processable shape memory composites based on degradable polymers. Polymer  10.1016/j.polymer.2017.06.066
Kong D, Nguyen KDQ, Megone W, Peng L and Gautrot JE (2017). The culture of HaCaT cells on liquid substrates is mediated by a mechanically strong liquid–liquid interface. Faraday Discuss.  vol. 204, 367-381. 10.1039/C7FD00091J
Di Cio S, Bøggild TML, Connelly J, Sutherland DS and Gautrot JE (2017). Differential integrin expression regulates cell sensing of the matrix nanoscale geometry. Acta Biomaterialia  vol. 50, 280-292. 10.1016/j.actbio.2016.11.069
Gh D, Kong D, Gautrot J and Vootla SK (2017). Fabrication and Characterization of Conductive Conjugated Polymer-Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications. Macromol Biosci  vol. 17, (7) 10.1002/mabi.201600443
Amabilino D, Bâldea I, Barykina O, Batteas J, Besenius P, Beton P, Bilbao N, Buck M, Chi L, Clarke S, Costantini G, Davidson J, Davies P, De Feyter S, Diaz Fernandez Y, Dwivedi D, Ernst K-H, Flood A, Gautrot J, Jabbarzadeh A, Korolkov V, Kühnle A, Lackinger M, Pradier C-M, Rahman T, Raval R, Schwaminger S, Seibel J, Tait SL and Teyssandier J (2017). Preparing macromolecular systems on surfaces: general discussion. Royal Society of Chemistry (Rsc)  Faraday Discussions  vol. 204, 395-418. 10.1039/c7fd90076g

2016

Gautrot JE (2016). Cell Sensing of the Physical Properties of the Microenvironment at Multiple Scales. Mechanobiology  Wiley  10.1002/9781118966174.ch19
Attwood SJ, Cortes E, Haining AW, Robinson B, Li D, Gautrot J and Del Río Hernández A (2016). Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment. Sci Rep  vol. 6, 34334-34334. 10.1038/srep34334
Colak B, Da Silva JCS, Soares TA and Gautrot JE (2016). Impact of the Molecular Environment on Thiol-Ene Coupling For Biofunctionalization and Conjugation. American Chemical Society  Bioconjugate Chemistry  vol. 27, (9) 2111-2123. 10.1021/acs.bioconjchem.6b00349
Nguyen KDQ, Megone WV, Kong D and Gautrot JE (2016). Ultrafast diffusion-controlled thiol-ene based crosslinking of silicone elastomers with tailored mechanical properties for biomedical applications. Polymer Chemistry  vol. 7, (33) 5281-5293. 10.1039/c6py01134a
Zhang X, Geven MA, Grijpma DW, Gautrot JE and Peijs T (2016). “Polymer-polymer composites for the design of strong and tough degradable biomaterials”. Materials Today Communications  vol. 8, 53-63. 10.1016/j.mtcomm.2016.05.001
An Y, Li D, Roohpour N, Gautrot JE and Barber AH (2016). Failure mechanisms in denture adhesives. Elsevier  Dental Materials  vol. 32, (5) 615-623. 10.1016/j.dental.2016.01.007
Di Cio S and Gautrot JE (2016). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Acta Biomaterialia  vol. 30, 26-48. 10.1016/j.actbio.2015.11.027
Tan KY, Ramstedt M, Colak B, Huck WTS and Gautrot JE (2016). Study of thiol–ene chemistry on polymer brushes and application to surface patterning and protein adsorption. Royal Society of Chemistry (Rsc)  Polymer Chemistry  vol. 7, (4) 979-990. 10.1039/c5py01687h

2015

Di Cio S and Gautrot JE (2015). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Elsevier  Acta Biomaterialia  vol. 30, 26-48. 10.1016/j.actbio.2015.11.027
Eglin D, Alini M, de Bruijn J, Gautrot J, Grijpma DW, Kamer L, Lai Y, Lu S, Peijs T, Peng J, Tang TT, Wang X, Richards RG and Qin L (2015). The RAPIDOS project-European and Chinese collaborative research on biomaterials. J Orthop Translat  vol. 3, (2) 78-84. 10.1016/j.jot.2015.02.001
Hackett AJ, Malmström J, Molino PJ, Gautrot JE, Zhang H, Higgins MJ, Wallace GG, Williams DE and Travas-Sejdic J (2015). Conductive surfaces with dynamic switching in response to temperature and salt. Royal Society of Chemistry (Rsc)  Journal of Materials Chemistry B  vol. 3, (48) 9285-9294. 10.1039/c5tb02125a

2014

Wang J, Zhou Y, Watkinson M, Gautrot J and Krause S (2014). High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers. Elsevier  Sensors and Actuators B: Chemical  vol. 209, 230-236. 10.1016/j.snb.2014.11.071
Krishnamoorthy M, Hakobyan S, Ramstedt M and GAUTROT JEE (2014). Surface initiated polymer brushes in the biomedical field: Applications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatings. American Chemical Society  Chemical Reviews  vol. 114, (21) 10976-11026. 10.1021/cr500252u
Deo DI, Gautrot JE, Sukhorukov GB and Wang W (2014). Biofunctionalization of PEGylated microcapsules for exclusive binding to protein substrates. Biomacromolecules  vol. 15, (7) 2555-2562. 10.1021/bm500412d
Gautrot JE, Malmström J, Sundh M, Margadant C, Sonnenberg A and Sutherland DS (2014). The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction. Nano Letters  vol. 14, (7) 3945-3952. 10.1021/nl501248y
Costa P, Gautrot JE and Connelly JT (2014). Directing cell migration using micropatterned and dynamically adhesive polymer brushes. Acta Biomater  vol. 10, (6) 2415-2422. 10.1016/j.actbio.2014.01.029

2013

Tan KY, Lin H, Ramstedt M, Watt FM, Huck WTS and Gautrot JE (2013). Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns. Integr Biol (Camb)  vol. 5, (6) 899-910. 10.1039/c3ib40026c
GAUTROT JEE, Rzhepishevska O, Hakobyan S, Ruhal R, Barbero D and Ramstedt M (2013). The surface charge of anti-bacterial coatings alters motility and biofilm architecture. Journal of Biomaterials Science: Polymer Edition  vol. 1, (6) 589-602. 10.1039/C3BM00197K

2012

Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WTS and Watt FM (2012). Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials  vol. 33, (21) 5221-5229. 10.1016/j.biomaterials.2012.04.009
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM and Huck WTS (2012). Extracellular-matrix tethering regulates stem-cell fate. Nature Materials  10.1038/nmat3339

2011

Rodriguez-Emmenegger C, Brynda E, Riedel T, Houska M, Šubr V, Alles AB, Hasan E, Gautrot JE and Huck WTS (2011). Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces. Macromol Rapid Commun  vol. 32, (13) 952-957. 10.1002/marc.201100189
Tan KY, Gautrot JE and Huck WTS (2011). Formation of pickering emulsions using ion-specific responsive colloids. Langmuir  vol. 27, (4) 1251-1259. 10.1021/la102904r
Connelly JT, Mishra A, Gautrot JE and Watt FM (2011). Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. Plos One  vol. 6, (11) 10.1371/journal.pone.0027259
Tan KY, Gautrot JE and Huck WTS (2011). Island brushes to control adhesion of water in oil droplets on planar surfaces. Soft Matter  vol. 7, (15) 7013-7020. 10.1039/c0sm01501f
Strandman S, Gautrot JE and Zhu XX (2011). Recent advances in entropy-driven ring-opening polymerizations. Polymer Chemistry  vol. 2, (4) 791-799. 10.1039/c0py00328j

2010

Connelly JT, Gautrot JE, Trappmann B, Tan DWM, Donati G, Huck WTS and Watt FM (2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biology  vol. 12, (7) 711-718. 10.1038/ncb2074
Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM and Huck WTS (2010). Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale. Biomaterials  vol. 31, (18) 5030-5041. 10.1016/j.biomaterials.2010.02.066
Gautrot JE, Huck WTS, Welch M and Ramstedt M (2010). Protein-resistant NTA-functionalized polymer brushes for selective and stable immobilization of histidine-tagged proteins. Acs Appl Mater Interfaces  vol. 2, (1) 193-202. 10.1021/am9006484
Therien-Aubin H, Gautrot JE, Shao Y, Zhang J and Zhu XX (2010). Shape memory properties of main chain bile acids polymers. Polymer  vol. 51, (1) 22-25. 10.1016/j.polymer.2009.11.027

2009

Gautrot JE and Zhu XX (2009). Shape memory polymers based on naturally-occurring bile acids. Macromolecules  vol. 42, (19) 7324-7331. 10.1021/ma901090r
Trmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WTS and Gautrot JE (2009). Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms. Biomacromolecules  vol. 10, (10) 2885-2894. 10.1021/bm900706r
Gautrot JE and Zhu XX (2009). Macrocyclic bile acids: from molecular recognition to degradable biomaterial building blocks. Journal of Materials Chemistry  vol. 19, (32) 5705-5716. 10.1039/b821340b
Huck WTS, Gautrot J and Watt F (2009). The effects of surface chemistry on epidermal stem cell differentiation. Abstracts of Papers of The American Chemical Society  vol. 237,
Hodge P and Gautrot JE (2009). Polymers containing in-chain quinone moieties: synthesis and properties. Polymer International  vol. 58, (3) 261-266. 10.1002/pi.2528
Gautrot JE, Zhang J, Shao Y and Zhu XX (2009). New degradable polymers made from natural compounds bile acids by ROMP. Abstracts of Papers of The American Chemical Society  vol. 237,
Gautrot JE, Hodge P, Helliwell M, Raftery J and Cupertino D (2009). Synthesis of electron-accepting polymers containing phenanthra-9,10-quinone units. Journal of Materials Chemistry  vol. 19, (24) 4148-4156. 10.1039/b901853k

2008

Gautrot JE and Zhu XX (2008). High molecular weight bile acid and ricinoleic acid-based copolyesters via entropy-driven ring-opening metathesis polymerisation. Chem Commun (Camb)  (14) 1674-1676. 10.1039/b719021b

2007

Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Silver nanoparticles stabilized by nitrocellulose as low conversion temperature precursors for inkjet-printed electronic circuits. 2007 Nsti Nanotechnology Conference and Trade Show - Nsti Nanotech 2007, Technical Proceedings  vol. 2, 68-71.
Charbonneau C, Gautrot JE, Hébert M-J, Zhu XX and Lerouge S (2007). Chondroitin-4-sulfate: a bioactive macromolecule to foster vascular healing around stent-grafts after endovascular aneurysm repair. Macromol Biosci  vol. 7, (5) 746-752. 10.1002/mabi.200700008
Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. Langmuir  vol. 23, (3) 1047-1051. 10.1021/la0624945
Gautrot JE and Zhu XX (2007). Molar mass of main-chain bile acid-based oligo-esters measured by SEC, MALDI-TOF spectrometry and NMR spectroscopy: a comparative study. Anal Chim Acta  vol. 581, (2) 281-286. 10.1016/j.aca.2006.08.020
Gautrot JE, Hodge P, Cupertino D and Helliwell M (2007). 2,6-Diaryl-9,10-anthraquinones as models for electron-accepting polymers. New Journal of Chemistry  vol. 31, (9) 1585-1593. 10.1039/b701257h
Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. Langmuir  vol. 23, (3) 1047-1051. 10.1021/la0624945
Chen Y, Gautrot JE, Li Z and Zhu XX (2007). Preparation and thermo-responsive light diffraction behaviors of soft polymerized crystalline colloidal arrays. Soft Matter  vol. 3, (5) 571-579. 10.1039/b611445h
Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Nitrocellulose-stabilized silver nanoparticles as low conversion temperature precursors useful for inkjet printed electronics. Journal of Materials Chemistry  vol. 17, (17) 1725-1730. 10.1039/b616446c
Gautrot JE and Hodge P (2007). Poly(dibenzo[a,c]phenazine-2,7-diyl)s -: Synthesis and characterisation of a new family of electron-accepting conjugated polymers. Polymer  vol. 48, (24) 7065-7077. 10.1016/j.polymer.2007.09.045

2006

Gautrot JE and Zhu XX (2006). Main-chain bile acid based degradable elastomers synthesized by entropy-driven ring-opening metathesis polymerization. Angew Chem Int Ed Engl  vol. 45, (41) 6872-6874. 10.1002/anie.200602096
Gautrot JE and Zhu XX (2006). Main‐Chain Bile Acid Based Degradable Elastomers Synthesized by Entropy‐Driven Ring‐Opening Metathesis Polymerization. Wiley  Angewandte Chemie  vol. 118, (41) 7026-7028. 10.1002/ange.200602096
Nguyen BT, Gautrot JE, Ji C, Brunner P-L, Nguyen MT and Zhu XX (2006). Enhancing the photoluminescence intensity of conjugated polycationic polymers by using quantum dots as antiaggregation reagents. Langmuir  vol. 22, (10) 4799-4803. 10.1021/la053399j
Gautrot JE and Zhu XX (2006). Biodegradable polymers based on bile acids and potential biomedical applications. Journal of Biomaterials Science-Polymer Edition  vol. 17, (10) 1123-1139. 10.1163/156856206778530713
Gautrot JE, Hodge P, Cupertino D and Helliwell M (2006). Experimental evidence for carbonyl-π electron cloud interactions. New Journal of Chemistry  vol. 30, (12) 1801-1807. 10.1039/b608628d

2005

Schroeder R, Majewski LA, Grell M, Maunoury J, Gautrot J, Hodge P and Turner M (2005). Electrode specific electropolymerization of ethylenedioxythiophene: Injection enhancement in organic transistors. Applied Physics Letters  vol. 87, (11) 10.1063/1.2035879

Grants

Grants of specific relevance to Predictive in vitro Models
Engineered Recombinant Strategies to Organogel Design for Food Product Formulations
Gautrot JE and Lee T-Y
Biotechnology and Biological Sciences Research Council (25-09-2022 - 29-09-2026)
Summary
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering
GAUTROT J
EUR1,999,389 European Research Council (01-09-2018 - 31-08-2024)
Summary


Design of an organ-on-a-chip model of soft-hard tissue interfaces
Gautrot JE and Da San Martino C
Biotechnology and Biological Sciences Research Council (22-09-2019 - 29-09-2023)
Summary
A biophysical model of gum reintegration on enamel
Gautrot JE
£108,279 Biotechnology and Biological Sciences Research Council (30-09-2019 - 29-09-2023)
Summary
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
Biddle AJ, Scemama A and Gautrot JEE
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-09-2022)
Protein Nanosheet-Stabilised Emulsions for Next Generation Biomanufacturing
GAUTROT J
EUR150,000 European Research Council (01-03-2021 - 31-08-2022)
Summary
Design of A Microfluidics Integrated Skin-on-a-Chip Tissue Model
Gautrot JE and Jones CF
Engineering and Physical Sciences Research Council (02-04-2017 - 02-10-2020)
Summary
To develop and exploit novel concepts and formulations for the cure chemistry of silicone composite materials and associated crosslinkers to improve the safety of silicone composites and improve their stability and cure rate.
Gautrot J
£75,443 Innovate UK (15-12-2016 - 31-08-2020)
An Ovarian Cancer Model on a Chip
Gautrot JE
£90,000 National Centre for the Replacement Refinement and Reduction of Animals in Research (31-08-2015 - 30-08-2018)
Summary
Photo-responsive graphene for anti-corrosive and conductive strong, compliant silicone nanocomposites
Bilotti E and Gautrot JE
£88,336 Engineering and Physical Sciences Research Council (30-09-2015 - 29-09-2016)
Summary