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Musculoskeletal Models

Queen Mary University of London holds two chairs of Versus Arthritis, prestigious awards in musculoskeletal research and is intimately linked to the Barts Health NHS Trust Musculoskeletal Clinical Service connecting the bench to the clinic. QMUL have also obtained a major investment from Bart’s Charity for the establishment of a new Centre of Excellence for Academic Trauma and Orthopaedic Surgery. Utilising human musculoskeletal models is highly advantageous to identify novel therapeutics that will halt inflammation as well as repair and regenerate damaged tissues.  

Musculoskeletal models research at QMUL is interdisciplinary combining biology, bioengineering and materials science. Key research areas include development and use of in vitro models for cartilage, bone, synovium, ligament/tendon and muscle. This is associated with research in tissue regeneration, musculoskeletal biomechanics, pathology, mechanobiology and implant biomaterials

Some of the state-of-the art projects include: 3D bioprinting human pluripotent stem cell-derived skeletal muscle constructs for disease modelling (Dr Lin/Dr. Connelly);  organ-on-a-chip models for safety testing of regenerative medicine products (Prof. Screen, Prof. Knight); development and testing of osteoinductive synthetic bone graft substitutes (Dr. Hing); as well as development of novel organ-chip models for synovium, tendon, bone and cartilage.