Prof Karin Hing
Professor of Biomaterials and Tissue Regeneration
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Biomaterials, Bone graft substitutes, 3D in vitro Bone models, Tissue Engineering, Orthobiologics and Regenerative Medicine, Bone
Interests
Development of 3D in vitro 'Tissue in a Tube' Models for screening of synthetic bone graft substitute safety and efficacy - to inform development of future biomaterial and orthobiologic innovations.The ultimate aim being to develop human ‘cohort specific’ models to innovate tailored interventions through understanding the role that the physico-chemical characteristics of scaffold structures or substrates play in modulating local environments and thus local cell responses and MSK tissue regeneration.
Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2023
SSNMR confirms silicate ion substitution in the apatitic structure of 0.8wt% Si hydroxyapatiteMafina M-K, Wilson RM, Rees GJ, Gierth P, Sullivan AC and Hing KA
Academia Materials Science, Academia.Edu Journals vol. 1 (1)
05-11-2023
SSNMR confirms silicate ion substitution in the apatitic
structure of 0.8wt% Si hydroxyapatiteMafina M-K, Wilson R, Rees G, Gierth P, Sullivan A and Hing K
Academia Materials Science
05-11-2023
2022
Photoelectrochemical Detection of Calcium Ions Based on Hematite Nanorod SensorsZhou B, Jiang Y, Guo Q, Das A, Jorge Sobrido A, Hing K, Zayats A and Krause S
Acs Applied Nano Materials, American Chemical Society
10-11-2022
2021
Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responsesZhou B, Das A, Zhong M, Guo Q, Zhang D-W, Hing KA, Sobrido AJ, Titirici M-M and Krause S
Biosensors and Bioelectronics, Elsevier vol. 180
02-03-2021
2020
Decellularized porcine xenograft for anterior cruciate ligament reconstruction: A histological study in sheep comparing cross-pin and cortical suspensory femoral fixationHexter AT, Hing KA, Haddad FS and Blunn G
Bone and Joint Research, The British Editorial Society of Bone & Joint Surgery vol. 9 (6), 293-301.
17-06-2020
2019
Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges.Wu F, Zhou B, Wang J, Zhong M, Das A, Watkinson M, Hing K, Zhang D-W and Krause S
Anal Chem
15-04-2019
2017
Use of a fluorescent probe to monitor the enhanced affinity of rh-BMP-2 to silicated-calcium phosphate synthetic bone graft substitutes under competitive conditionsMafina MK, Sullivan AC and Hing KA
Materials Science and Engineering C vol. 80, 207-212.
01-11-2017
The effect of the incorporation of fluoride into strontium containing bioactive glassesSriranganathan D, Chen X, Hing KA, Kanwal N and Hill RG
Journal of Non-Crystalline Solids vol. 457, 25-30.
01-02-2017
2016
The effect of increased microporosity on bone formation within silicate-substituted scaffolds in an ovine posterolateral spinal fusion model.Coathup MJ, Blunn GW, Campion C, Ho C-Y and Hing KA
J Biomed Mater Res B Appl Biomater vol. 105 (4), 805-814.
14-01-2016
2015
Strontium substituted bioactive glasses for tissue engineered scaffolds: the importance of octacalcium phosphateSriranganathan D, Kanwal N, Hing KA and Hill RG
Journal of Materials Science: Materials in Medicine, Springer Nature vol. 27 (2)
24-12-2015
Efficacy of silicate-substituted calcium phosphate with enhanced strut porosity as a standalone bone graft substitute and autograft extender in an ovine distal femoral critical defect model.Hutchens SA, Campion C, Assad M, Chagnon M and Hing KA
J Mater Sci Mater Med vol. 27 (1), 20-20.
18-12-2015
Apatite formation of bioactive glasses is enhanced by low additions of fluoride but delayed in the presence of serum proteinsShah FA, Brauer DS, Hill RG and Hing KA
Materials Letters, Elsevier vol. 153, 143-147.
01-08-2015
2014
Fluoride-containing bioactive glasses and Bioglass® 45S5 form apatite in low pH cell culture mediumShah FA, Brauer DS, Desai N, Hill RG and Hing KA
Materials Letters vol. 119, 96-99.
15-03-2014
Influence of cell culture medium composition on in vitro dissolution behavior of a fluoride-containing bioactive glassShah FA, Brauer DS, Wilson RM, Hill RG and Hing KA
Journal of Biomedical Materials Research - Part A vol. 102 (3), 647-654.
01-03-2014
2013
HMSC proliferation and differentiation are dependent on chemistry and surface roughness of calcium phosphate bone substitutesCastagna V, Olivares-Navarrete R, Schwartz Z, Boyan BD and Hing KA
European Cells and Materials vol. 26 (SUPPL. 3)
08-08-2013
Microstructure and chemistry affects apatite nucleation on calcium phosphate bone graft substitutesCampion CR, Ball SL, Clarke DL and Hing KA
Journal of Materials Science: Materials in Medicine vol. 24 (3), 597-610.
01-03-2013
Development of novel fluorescent probes for the analysis of protein interactions under physiological conditions with medical devices.Mafina M-K, Hing KA and Sullivan AC
Langmuir vol. 29 (5), 1420-1426.
05-02-2013
Antibacterial effect of incorporating silver ions in electrochemically deposited hydroxyapatite coating: An experimental study.Ghani Y, Coathup MJ, Hing KA and Blunn GW
Jrsm Short Rep vol. 4 (9)
01-01-2013
Contributor contact detailsRuys A, Tampieri A, Sprio S, Ehrlich H, Rabiei R, Dastjerdi AK, Mirkhalaf M, Barthelat F, Chánová EM, Rypáček F, Boughton P, Roger G, Rohanizadeh R, Mason RS, Boughton E, McLennan SV, Le Bao Ha T, Hing KA, Zhu J, Hu J, Marchant RE and Campbell D
In Biomimetic Biomaterials, Elsevier ix-xi.
01-01-2013
2012
Effect of increased strut porosity of calcium phosphate bone graft substitute biomaterials on osteoinductionCoathup MJ, Hing KA, Samizadeh S, Chan O, Fang YS, Campion C, Buckland T and Blunn GW
Journal of Biomedical Materials Research - Part A vol. 100 A (6), 1550-1555.
01-06-2012
Development of a hydroxyapatite coating containing silver for the prevention of peri-prosthetic infection.Ghani Y, Coathup MJ, Hing KA and Blunn GW
J Orthop Res vol. 30 (3), 356-363.
01-03-2012
The effects of microporosity on osteoinduction of calcium phosphate bone graft substitute biomaterialsChan O, Coathup MJ, Nesbitt A, Ho CY, Hing KA, Buckland T, Campion C and Blunn GW
Acta Biomaterialia vol. 8 (7), 2788-2794.
01-01-2012
Bioactivity And Bone Formation In Silicon-Substituted HydroxyapatiteOzad U, Parish A and Hing KA
Sakarya University Journal of Science, Lookus Bilisim vol. 16 (3), 170-177.
01-01-2012
2011
The osteoinductivity of silicate-substituted calcium phosphate.Coathup MJ, Samizadeh S, Fang YS, Buckland T, Hing KA and Blunn GW
J Bone Joint Surg Am vol. 93 (23), 2219-2226.
07-12-2011
The quantitative and qualitative analysis bone ingrowth network quality of hydroxyapatite implants over time to investigate the process of internal bone growth via novel automated 3D image processingParish A, Davis G and Hing K
24th European Conference On Biomaterials - Annual Conference of The European Society For Biomaterials
01-12-2011
Fibronectin adsorption to stoichiometric and silicate substituted hydroxyapatite sensitive to FN concentration and presence of serum proteinsCastagna V, Sullivan A and Hing K
24th European Conference On Biomaterials - Annual Conference of The European Society For Biomaterials
01-12-2011
Effects of serum protein on ionic exchange between culture medium and microporous hydroxyapatite and silicate-substituted hydroxyapatiteGuth K, Campion C, Buckland T and Hing KA
Journal of Materials Science: Materials in Medicine vol. 22 (10), 2155-2164.
01-10-2011
Increasing strut porosity in silicate-substituted calcium-phosphate bone graft substitutes enhances osteogenesisCampion CR, Chander C, Buckland T and Hing K
Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 97 B (2), 245-254.
01-05-2011
Behaviour of fibronectin on interaction with stoichiometric and silicate substituted hydroxyapatite bone graft substitiutesCastagna V, Sullivan A and Hing KA
European Cells and Materials vol. 22 (SUPPL.2)
01-01-2011
Recording and evaluating the effect of silicon-substitution on protein adsorption/desorption to hydroxyapatiteMafina MK, Sullivan AC and Hing KA
European Cells and Materials vol. 22 (SUPPL.2)
01-01-2011
Automated computation of 3D histomorphometry within implanted hydroxyapatite porous scaffoldsParish AJB, Davis GR and Hing KA
European Cells and Materials vol. 22 (SUPPL.2)
01-01-2011
2010
Surface physiochemistry affects protein adsorption to stoichiometric and silicate-substituted microporous hydroxyapatitesGuth K, Campion C, Buckland T and Hing KA
Advanced Engineering Materials vol. 12 (4)
01-04-2010
Effect of silicate-substitution on attachment and early development of human osteoblast-like cells seeded on microporous hydroxyapatite discsGuth K, Campion C, Buckland T and Hing KA
Advanced Engineering Materials vol. 12 (1-2)
01-02-2010
2009
Monitoring the effect of silicate substitution on protein adsorption/desorption to hydroxyapatiteMafina MK, Sullivan AC and Hing KA
European Cells and Materials vol. 18 (SUPPL. 2)
01-07-2009
2008
Osseoinduction by calcium phosphate bone substitutes is a function of chemical composition and structureSamizadeh S, Amogbokpa J, Fang SC, Coathup MJ, Hing KA, Buckland T and Blunn GW
8th World Biomaterials Congress 2008 vol. 2
01-12-2008
Biomaterials - Where biology, physics, chemistry, engineering and medicine meetHing KA
Journal of Physics: Conference Series vol. 105 (1)
01-03-2008
Nano-scale manipulation of silicate-substituted apatite chemistry impacts surface charge, hydrophilicity, protein adsorption and cell attachment.Rashid N, Harding I, Buckland T and HING KA
, Editors: Meenan BJ and Boyd AR. International Journal of Nano and Biomaterials vol. 1 (3), 299-319.
01-01-2008
2007
Comparative performance of three ceramic bone graft substitutes.Hing KA, Wilson LF and Buckland T
Spine J vol. 7 (4), 475-490.
01-01-2007
2006
Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds.Hing KA, Revell PA, Smith N and Buckland T
Biomaterials vol. 27 (29), 5014-5026.
01-10-2006
In vitro testing of Nd : YAG laser processed calcium phosphate coatings.De Carlos A, Lusquinos F, Pou J, Leon B, Perez-Amor M, Driessens FCM, HING KA, Best S and Bonfield W
Journal of Materials Science Materials in Medicine vol. 17 (11), 1153-1160.
01-01-2006
2005
Surface charge and the effect of excess calcium ions on the hydroxyapatite surface.Harding IS, Rashid N and Hing KA
Biomaterials vol. 26 (34), 6818-6826.
01-12-2005
Hydroxyapatite promotes superior keratocyte adhesion and proliferation in comparison with current keratoprosthesis skirt materialsMehta JS, Futter CE, Sandeman SR, Faragher RGAF, Hing KA, Tanner KE and Allan BDS
Brit J Ophthalmol vol. 89 (10), 1356-1362.
01-10-2005
Microporosity enhances bioactivity of synthetic bone graft substitutesHING KA, Annaz B, Saeed S, Revell PA and Buckland T
Journal of Materials Science Materials in Medicine vol. 16 (5), 467-475.
01-01-2005
Bioceramic bone graft substitutes: Influence of porosity and chemistryHing KA
Int J Appl Ceram Tec vol. 2 (3), 184-199.
01-01-2005
2004
Bone repair in the twenty-first century: biology, chemistry or engineering?Hing KA
Philos Trans a Math Phys Eng Sci vol. 362 (1825), 2821-2850.
15-12-2004
Effect of silicate substitution on the surface charge of hydroxyapatiteRashid N, Harding I and Hing KA
Transactions - 7th World Biomaterials Congress
01-12-2004
Bone development is sensitive to silicon level in substituted apatitesHing KA, Saeed S, Annaz B, Buckland T and Revell PA
Transactions - 7th World Biomaterials Congress
01-12-2004
Microporosity enhances bioactivity of synthetic bone graft substitutesHing KA, Saeed S, Annaz B, Buckland T and Revell PA
Transactions - 7th World Biomaterials Congress
01-12-2004
HA activates T cells and causes inflammation in liver and spleen from rabbits following intraosseous implantationSaeed S, Hing K and Revell PA
Transactions - 7th World Biomaterials Congress
01-12-2004
The role of microporosity in synthetic porous ceramicsAnnaz B, Hing KA, Kayser M, Buckland T and Di Silvio L
Transactions - 7th World Biomaterials Congress
01-12-2004
An ultrastructural study of cellular response to variation in porosity in phase-pure hydroxyapatite.Annaz B, Hing KA, Kayser M, Buckland T and Di Silvio L
J Microsc vol. 216 (Pt 2), 97-109.
01-11-2004
Porosity variation in hydroxyapatite and osteoblast morphology: a scanning electron microscopy study.Annaz B, Hing KA, Kayser M, Buckland T and Di Silvio L
J Microsc vol. 215 (Pt 1), 100-110.
01-07-2004
Mediation of bone ingrowth in porous hydroxyaptite bone graft substitutesHING KA, Tanner KE, Best SM, Bonfield W and Revell PA
Journal of Biomedical Materials Research vol. 68A, 187-200.
01-01-2004
Novel Bioceramic Foams For Bone GraftingHING KA, Revell PA, McInness T and Damien E
Journal of Bone & Joint Surgery - British Volume vol. 86-B Suppl I:II
01-01-2004
Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes.Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA
J Biomed Mater Res A vol. 68 (1), 187-200.
01-01-2004
2003
A preliminary study on the enhancement of the osteointegration of a novel synthetic hydroxyapatite scaffold in vivo.Damien E, Hing K, Saeed S and Revell PA
J Biomed Mater Res A vol. 66 (2), 241-246.
01-08-2003
Calcium phosphate coatings obtained by Nd:YAG laser cladding: physicochemical and biologic properties.Lusquiños F, De Carlos A, Pou J, Arias JL, Boutinguiza M, León B, Pérez-Amor M, Driessens FCM, Hing K, Gibson I, Best S and Bonfield W
J Biomed Mater Res A vol. 64 (4), 630-637.
15-03-2003
2002
A comparative study on the in vivo behavior of hydroxyapatite and silicon substituted hydroxyapatite granules.Patel N, Best SM, Bonfield W, Gibson IR, Hing KA, Damien E and Revell PA
J Mater Sci Mater Med vol. 13 (12), 1199-1206.
01-12-2002
2001
Insulin like growth factor (IGF-I) increases the bioactivity of porous hydroxyapatite (PHA) in vivo in rabbits.Damien E, MacInnes T, Hing K and Revell PA
J Pathol vol. 193, 6A-6A.
01-03-2001
1999
Characterization of porous hydroxyapatite.Hing KA, Best SM and Bonfield W
J Mater Sci Mater Med vol. 10 (3), 135-145.
01-03-1999
Macroporous hydroxyapatites: Potential drug delivery systemsDi Silvio L, Hing K and Bonfield W
Proceedings of The Controlled Release Society (26), 1152-1153.
01-01-1999
Quantification of bone ingrowth within bone-derived porous hydroxyapatite implants of varying density.Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA
J Mater Sci Mater Med vol. 10 (10/11), 663-670.
01-01-1999
1998
Histomorphological and biomechanical characterization of calcium phosphates in the osseous environment.Hing KA, Best SM, Tanner KE, Revell PA and Bonfield W
Proc Inst Mech Eng H vol. 212 (6), 437-451.
01-01-1998
1997
Biomechanical assessment of bone ingrowth in porous hydroxyapatite.Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA
J Mater Sci Mater Med vol. 8 (12), 731-736.
01-12-1997
1996
Histomorphometric and biomechanical assessment of bone ingrowth in porous hydroxyapatiteHing KA, Best SM, Revell PA, Tanner KE and Bonfield W
Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 2
01-12-1996
Assessment of porous hydroxyapatite for bone replacementHING KA
, Editors: Best SM and Bonfield W.
01-01-1996
Grants
3D perfusion bioreactor studentship Baxter - EPSRC DTP CASE Conversion 2021Karin Hing
£30,000 Baxter Healthcare Corporation
21-09-2021 - 20-09-2025
KTP AKT (QMUL-Lucideon) - Radio Opaque Cements and Osteoclast Testing: Traceable Bio-Remodellable CementsKarin Hing and Simon Rawlinson
£41,283 Innovate UK
25-03-2024 - 24-07-2024
KTP with Lucideon: Cell testing to assist development of novel biomaterialsKarin Hing and Simon Rawlinson
£256,237 Innovate UK
17-02-2021 - 17-02-2024
Bioresorbable bioactive composites Kick offKarin Hing and Emiliano Bilotti
£50,243 Baxter Healthcare Corporation
11-01-2021 - 22-01-2025
Bioactive bioresorbable composites for load bearing guided bone regenerationKarin Hing
£29,000 Baxter Healthcare Corporation
01-10-2020 - 30-09-2024
Development of mechanically enhanced osteoinductive synthetic bone graft substitutesKarin Hing
£87,500 Apatech Ltd
01-10-2017 - 31-03-2022
Doctoral Educational Research AgreementKarin Hing
£79,714 Baxter Healthcare Corporation
01-01-2015 - 31-03-2022