Prof Karin Hing
BSc, PhD, CEng, MIMMM, FHEA, FRSA, FWESBaxter/Royal Academy of Engineering Research Chair in Biomaterials and Tissue Regeneration
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Biomaterials, Bone graft substitutes, 3D in vitro Bone models, Tissue Engineering, Orthobiologics and Regenerative Medicine, Bone
Interests
Development of 3D in vitro 'Tissue in a Tube' Models for screening of synthetic bone graft substitute safety and efficacy - to inform development of future biomaterial and orthobiologic innovations.The ultimate aim being to develop human ‘cohort specific’ models to innovate tailored interventions through understanding the role that the physico-chemical characteristics of scaffold structures or substrates play in modulating local environments and thus local cell responses and MSK tissue regeneration.
Publications
2023
SSNMR confirms silicate ion substitution in the apatitic structure of 0.8wt% Si hydroxyapatiteMafina M-K, Wilson RM, Rees GJ, Gierth P, Sullivan AC, Hing KA
Academia Materials Science, Academia.Edu Journals vol. 1 (1)
05-11-2023
SSNMR confirms silicate ion substitution in the apatitic\nstructure of 0.8wt% Si hydroxyapatiteMafina M-K, Wilson R, Rees G, Gierth P, Sullivan A, Hing K
Academia Materials Science
05-11-2023
2022
Photoelectrochemical Detection of Calcium Ions Based on Hematite Nanorod SensorsZhou B, Jiang Y, Guo Q, Das A, Sobrido ABJ, Hing KA, Zayats AV, Krause S
Acs Applied Nano Materials, American Chemical Society (Acs) vol. 5 (11), 17087-17094.
10-11-2022
Photoelectrochemical detection of calcium ions based on hematite nanorod sensor substratesZhou B, Jiang Y, Guo Q, Das A, Sobrido A, Hing K, Zayats A, Krause S
In American Chemical Society (Acs)
06-09-2022
OSTEOGENIC ACTIVITY OF ACTIFUSE™ IS NOT ENHANCED BY PRE-ADSORBED BMP2Kohnken-Sawall J, Rawlinson SCF, Hing KA
01-01-2022
2021
Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responsesZhou B, Das A, Zhong M, Guo Q, Zhang D-W, Hing KA, Sobrido AJ, Titirici M-M et al.
Biosensors and Bioelectronics, Elsevier Bv vol. 180, 113121-113121.
01-05-2021
2020
Decellularized porcine xenograft for anterior cruciate ligament reconstructionHexter AT, Hing KA, Haddad FS, Blunn G
Bone &Amp; Joint Research, British Editorial Society of Bone & Joint Surgery vol. 9 (6), 293-301.
01-06-2020
2019
Photoelectrochemical Imaging System for the Mapping of Cell Surface ChargesWu F, Zhou B, Wang J, Zhong M, Das A, Watkinson M, Hing K, Zhang D-W et al.
Analytical Chemistry, American Chemical Society (Acs) vol. 91 (9), 5896-5903.
15-04-2019
2017
Use of a fluorescent probe to monitor the enhanced affinity of rh-BMP-2 to silicated-calcium phosphate synthetic bone graft substitutes under competitive conditionsMafina M-K, Sullivan AC, Hing KA
Materials Science and Engineering: C, Elsevier Bv vol. 80, 207-212.
01-11-2017
The effect of the incorporation of fluoride into strontium containing bioactive glassesSriranganathan D, Chen X, Hing KA, Kanwal N, Hill RG
Journal of Non-Crystalline Solids, Elsevier Bv vol. 457, 25-30.
01-02-2017
2016
Porous Bone Graft SubstitutesCampion C, Hing KA
347-371.
23-12-2016
The effect of increased microporosity on bone formation within silicate‐substituted scaffolds in an ovine posterolateral spinal fusion modelCoathup MJ, Blunn GW, Campion C, Ho C, Hing KA
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley vol. 105 (4), 805-814.
14-01-2016
2015
Strontium substituted bioactive glasses for tissue engineered scaffolds: the importance of octacalcium phosphateSriranganathan D, Kanwal N, Hing KA, Hill RG
Journal of Materials Science: Materials in Medicine, Springer Science and Business Media Llc vol. 27 (2)
24-12-2015
Efficacy of silicate-substituted calcium phosphate with enhanced strut porosity as a standalone bone graft substitute and autograft extender in an ovine distal femoral critical defect modelHutchens SA, Campion C, Assad M, Chagnon M, Hing KA
Journal of Materials Science: Materials in Medicine, Springer Science and Business Media Llc vol. 27 (1)
18-12-2015
Apatite formation of bioactive glasses is enhanced by low additions of fluoride but delayed in the presence of serum proteinsShah FA, Brauer DS, Hill RG, Hing KA
Materials Letters, Elsevier Bv vol. 153, 143-147.
01-08-2015
2014
Fluoride-containing bioactive glasses and Bioglass® 45S5 form apatite in low pH cell culture mediumShah FA, Brauer DS, Desai N, Hill RG, Hing KA
Materials Letters, Elsevier Bv vol. 119, 96-99.
01-03-2014
2013
Antibacterial effect of incorporating silver ions in electrochemically deposited hydroxyapatite coating: An experimental studyGhani Y, Coathup MJ, Hing KA, Blunn GW
Jrsm Short Reports, Sage Publications vol. 4 (9)
23-08-2013
HMSC proliferation and differentiation are dependent on chemistry and surface roughness of calcium phosphate bone substitutesCastagna V, Olivares-Navarrete R, Schwartz Z, Boyan BD, Hing KA
European Cells and Materials vol. 26 (SUPPL. 3)
08-08-2013
Influence of cell culture medium composition on in vitro dissolution behavior of a fluoride‐containing bioactive glassShah FA, Brauer DS, Wilson RM, Hill RG, Hing KA
Journal of Biomedical Materials Research Part A, Wiley vol. 102 (3), 647-654.
18-05-2013
Development of Novel Fluorescent Probes for the Analysis of Protein Interactions under Physiological Conditions with Medical DevicesMafina M-K, Hing KA, Sullivan AC
Langmuir, American Chemical Society (Acs) vol. 29 (5), 1420-1426.
25-01-2013
Contributor contact detailsRuys A, Tampieri A, Sprio S, Ehrlich H, Rabiei R, Dastjerdi AK, Mirkhalaf M, Barthelat F et al.
In Biomimetic Biomaterials, Elsevier ix-xi.
01-01-2013
8 Biomimetic bone regenerationHing KA
In Biomimetic Biomaterials, Elsevier 207-237.
01-01-2013
2012
Microstructure and chemistry affects apatite nucleation on calcium phosphate bone graft substitutesCampion CR, Ball SL, Clarke DL, Hing KA
Journal of Materials Science: Materials in Medicine, Springer Science and Business Media Llc vol. 24 (3), 597-610.
16-12-2012
The effects of microporosity on osteoinduction of calcium phosphate bone graft substitute biomaterialsChan O, Coathup MJ, Nesbitt A, Ho C-Y, Hing KA, Buckland T, Campion C, Blunn GW
Acta Biomaterialia, Elsevier Bv vol. 8 (7), 2788-2794.
01-07-2012
Effect of increased strut porosity of calcium phosphate bone graft substitute biomaterials on osteoinductionCoathup MJ, Hing KA, Samizadeh S, Chan O, Fang YS, Campion C, Buckland T, Blunn GW
Journal of Biomedical Materials Research Part A, Wiley vol. 100A (6), 1550-1555.
15-03-2012
Microstructure and chemistry affects the in vitro bioactivity of calcium phosphate bone graft substitutesCampion R, Ball S, Clarke D, Hing K
01-01-2012
Microstructure and chemistry affects the in vitro bioactivity of calcium phosphate bone graft substitutesCampion C, Ball S, Clarke D, Hing K
01-01-2012
Bioactivity And Bone Formation In Silicon-Substituted HydroxyapatiteOzad U, Parish A, Hing KA
SaÜ Fen Bilimleri EnstitüSü Dergisi, Lookus Bilisim a.S. vol. 16 (3), 170-177.
01-01-2012
2011
The Osteoinductivity of Silicate-Substituted Calcium PhosphateCoathup MJ, Samizadeh S, Fang YS, Buckland T, Hing KA, Blunn GW
Journal of Bone and Joint Surgery, Ovid Technologies (Wolters Kluwer Health) vol. 93 (23), 2219-2226.
07-12-2011
The quantitative and qualitative analysis bone ingrowth network quality of hydroxyapatite implants over time to investigate the process of internal bone growth via novel automated 3D image processingParish A, Davis G, Hing K
24th European Conference On Biomaterials Annual Conference of The European Society For Biomaterials
01-12-2011
Fibronectin adsorption to stoichiometric and silicate substituted hydroxyapatite sensitive to FN concentration and presence of serum proteinsCastagna V, Sullivan A, Hing K
24th European Conference On Biomaterials Annual Conference of The European Society For Biomaterials
01-12-2011
Effects of serum protein on ionic exchange between culture medium and microporous hydroxyapatite and silicate-substituted hydroxyapatiteGuth K, Campion C, Buckland T, Hing KA
J Mater Sci-Mater M vol. 22 (10), 2155-2164.
01-10-2011
Development of a hydroxyapatite coating containing silver for the prevention of peri‐prosthetic infectionGhani Y, Coathup MJ, Hing KA, Blunn GW
Journal of Orthopaedic Research, Wiley vol. 30 (3), 356-363.
07-09-2011
Increasing strut porosity in silicate-substituted calcium-phosphate bone graft substitutes enhances osteogenesisCampion CR, Chander C, Buckland T, Hing K
J Biomed Mater Res B vol. 97B (2), 245-254.
01-05-2011
Behaviour of fibronectin on interaction with stoichiometric and silicate substituted hydroxyapatite bone graft substitiutesCastagna V, Sullivan A, Hing KA
European Cells and Materials vol. 22 (SUPPL.2)
01-01-2011
Recording and evaluating the effect of silicon-substitution on protein adsorption/desorption to hydroxyapatiteMafina MK, Sullivan AC, Hing KA
European Cells and Materials vol. 22 (SUPPL.2)
01-01-2011
Automated computation of 3D histomorphometry within implanted hydroxyapatite porous scaffoldsParish AJB, Davis GR, Hing KA
European Cells and Materials vol. 22 (SUPPL.2)
01-01-2011
2010
Surface Physiochemistry Affects Protein Adsorption to Stoichiometric and Silicate-Substituted Microporous HydroxyapatitesGuth K, Campion C, Buckand T, Hing KA
Adv Eng Mater vol. 12 (4), B113-B121.
01-04-2010
Effect of Silicate-Substitution on Attachment and Early Development of Human Osteoblast-Like Cells Seeded on Microporous Hydroxyapatite DiscsGuth K, Campion C, Buckland T, Hing KA
Adv Eng Mater vol. 12 (1-2), B26-B36.
01-02-2010
Tissue engineeringHing K
Materials World vol. 18 (9), 28-30.
01-01-2010
2009
Monitoring the effect of silicate substitution on protein adsorption/desorption to hydroxyapatiteMafina MK, Sullivan AC, Hing KA
European Cells and Materials vol. 18 (SUPPL. 2)
01-07-2009
foamed ceramicsHING KA, Bonfield W
US Patent US8613876 B2.
25-06-2009
Encouraging Nature with Ceramics: The roles of surface roughness and physio-chemistry on cell response to substituted apatitesChristophy C, Rashid N, Di Silvio L, Hing KA
01-01-2009
2008
Osseoinduction by calcium phosphate bone substitutes is a function of chemical composition and structureSamizadeh S, Amogbokpa J, Fang SC, Coathup MJ, Hing KA, Buckland T, Blunn GW
8th World Biomaterials Congress 2008 vol. 2
01-12-2008
Biomaterials — where biology, physics, chemistry, engineering and medicine meetHing KA
01-03-2008
Biomaterials - Where biology, physics, chemistry, engineering and medicine meetHing KA
Journal of Physics Conference Series vol. 105 (1)
01-03-2008
Nano-scale manipulation of silicate-substituted apatite chemistry impacts surface charge, hydrophilicity, protein adsorption and cell attachmentRashid N, Harding IS, Buckland T, Hing KA
International Journal of Nano and Biomaterials, Inderscience Publishers vol. 1 (3), 299-299.
01-01-2008
2007
Comparative performance of three ceramic bone graft substitutesHing KA, Wilson LE, Buckland T
Spine J vol. 7 (4), 475-490.
01-07-2007
Osteoclastic responses to phase pure hydroxyapatite (HA) and silicon (SI)-substituted HAMabilleau G, Xia Z, Hing KA, Buckland T, Sabokbar A
01-01-2007
2006
In vitro testing of Nd:YAG laser processed calcium phosphate coatingsDe Carlos A, Lusquiños F, Pou J, León B, Pérez-Amor M, Driessens FCM, Hing K, Best S et al.
01-11-2006
Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffoldsHing KA, Revell PA, Smith N, Buckland T
Biomaterials vol. 27 (29), 5014-5026.
01-10-2006
Silicon Dissolution from Microporous Silicon Substituted Hydroxyapatite and its Effect on Osteoblast BehaviourGuth K, Buckland T, Hing KA
01-05-2006
In vitro testing of Nd : YAG laser processed calcium phosphate coatings.De Carlos A, Lusquinos F, Pou J, Leon B, Perez-Amor M, Driessens FCM, HING KA, Best S et al.
Journal of Materials Science Materials in Medicine vol. 17 (11), 1153-1160.
01-01-2006
2005
Surface charge and the effect of excess calcium ions on the hydroxyapatite surfaceHarding IS, Rashid N, Hing KA
Biomaterials vol. 26 (34), 6818-6826.
01-12-2005
Hydroxyapatite promotes superior keratocyte adhesion and proliferation in comparison with current keratoprosthesis skirt materialsMehta JS
British Journal of Ophthalmology, Bmj vol. 89 (10), 1356-1362.
01-10-2005
Bioceramic Bone Graft Substitutes: Influence of Porosity and ChemistryHing KA
International Journal of Applied Ceramic Technology, Wiley vol. 2 (3), 184-199.
01-05-2005
Microporosity enhances bioactivity of synthetic bone graft substitutesHing KA, Annaz B, Saeed S, Revell PA, Buckland T
01-05-2005
Microporosity enhances bioactivity of synthetic bone graft substitutesHING KA, Annaz B, Saeed S, Revell PA, Buckland T
Journal of Materials Science Materials in Medicine vol. 16 (5), 467-475.
01-01-2005
2004
Bone repair in the twenty-first century: biology, chemistry or engineering?Hing KA
Philos T Roy Soc A vol. 362 (1825), 2821-2850.
15-12-2004
Effect of silicate substitution on the surface charge of hydroxyapatiteRashid N, Harding I, Hing KA
Transactions 7th World Biomaterials Congress
01-12-2004
Bone development is sensitive to silicon level in substituted apatitesHing KA, Saeed S, Annaz B, Buckland T, Revell PA
Transactions 7th World Biomaterials Congress
01-12-2004
Microporosity enhances bioactivity of synthetic bone graft substitutesHing KA, Saeed S, Annaz B, Buckland T, Revell PA
Transactions 7th World Biomaterials Congress
01-12-2004
HA activates T cells and causes inflammation in liver and spleen from rabbits following intraosseous implantationSaeed S, Hing K, Revell PA
Transactions 7th World Biomaterials Congress
01-12-2004
The role of microporosity in synthetic porous ceramicsAnnaz B, Hing KA, Kayser M, Buckland T, Di Silvio L
Transactions 7th World Biomaterials Congress
01-12-2004
An ultrastructural study of cellular response to variation in porosity in phase-pure hydroxyapatiteAnnaz B, Hing KA, Kayser M, Buckland T, Di Silvio L
J Microsc-Oxford vol. 216, 97-109.
01-11-2004
Porosity variation in hydroxyapatite and osteoblast morphology: a scanning electron microscopy studyAnnaz B, Hing KA, Kayser M, Buckland T, Di Silvio L
J Microsc-Oxford vol. 215, 100-110.
01-07-2004
Novel Bioceramic Foams For Bone GraftingHING KA, Revell PA, McInness T, Damien E
Journal of Bone & Joint Surgery - British Volume vol. 86-B Suppl I:II
01-01-2004
Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutesHing KA, Best SM, Tanner KE, Bonfield W, Revell PA
J Biomed Mater Res A vol. 68A (1), 187-200.
01-01-2004
2003
Microporosity Affects Bioactivity of Macroporous Hydroxyapatite Bone Graft SubstitutesHing KA, Saeed S, Annaz B, Buckland T, Revell PA
15-12-2003
Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutesHing KA, Best SM, Tanner KE, Bonfield W, Revell PA
Journal of Biomedical Materials Research Part A, Wiley vol. 68A (1), 187-200.
01-12-2003
A preliminary study on the enhancement of the osteointegration of a novel synthetic hydroxyapatite scaffold in vivoDamien E, Hing K, Saeed S, Revell PA
Journal of Biomedical Materials Research Part A vol. 66A (2), 241-246.
01-08-2003
Calcium phosphate coatings obtained by Nd : YAG laser cladding: Physicochemical and biologic propertiesLusquinos F, De Carlos A, Pou J, Arias JL, Boutinguiza M, Leon B, Perez-Amor M, Driessens FCM et al.
J Biomed Mater Res A vol. 64A (4), 630-637.
15-03-2003
2002
A comparative study on the in vivo behavior of hydroxyapatite and silicon substituted hydroxyapatite granulesPatel N, Best SM, Bonfield W, Gibson IR, Hing KA, Damien E, Revell PA
J Mater Sci-Mater M vol. 13 (12), 1199-1206.
01-12-2002
2001
Fabrication of Porous Hydroxyapatite by Foam TechniquePedroviejo JJ, Reusmaazran Yusof M, Besar I, Mustafa R, Hing KA
01-12-2001
Characterisation of Mono- and Biphasic Calcium Phosphates GranulesKe S, Gibson IR, Hing KA
01-11-2001
The In Vivo Response of Phase Pure Hydroxyapatite and Carbonate Substituted Hydroxyapaite Granules of Varying Size RangesPatel N, Gibson IR, Hing KA, Best S, Damien E, Revell PA, Bonfield W
01-11-2001
Enhanced In Vivo Response to Silicate-Substituted HydroxyapatiteGibson IR, Hing KA, Revell PA, Santos JD, Best S, Bonfield W
01-11-2001
Insulin like growth factor (IGF-I) increases the bioactivity of porous hydroxyapatite (PHA) in vivo in rabbits.Damien E, MacInnes T, Hing K, Revell PA
Journal of Pathology vol. 193, 6A-6A.
01-01-2001
2000
Influence of Phase Purity on the in Vivo Response to HydroxyapatiteHing KA, Gibson IR, Revell PA, Best S, Bonfield W
01-09-2000
Preparation and Characterisation of Hydroxyapatite and Carbonate Substituted Hydroxyapatite GranulesPatel N, Best S, Gibson IR, Ke S, Hing KA, Bonfield W
01-09-2000
1999
A COMPARATIVE STUDY OF VARIOUS ASSAYS FOR IN VITRO BIOCOMPATIBILITY ASSESSMENT OF EXPERIMENTAL ZIRCONIAHuang J, Hing KA, Best SM, Lee DA, Silvio LD, Bonfield W
Proceedings of the 12th International Symposium on Ceramics in Medicine.
01-10-1999
PHYSICAL PROPERTIES OF A NOVEL GLASS-CERAMIC-REINFORCED HYRDROXYAPATITE COMPOSITEParsons NS, Hing KA, Buckland T, Best SM, Bonfield W
Proceedings of the 12th International Symposium on Ceramics in Medicine.
01-10-1999
EFFECT OF CARBONATE CONTENT ON THE RESPONSE OF HUMAN OSTEOBLAST-LIKE CELLS TO CARBONATE SUBSTITUTED HYDROXYAPATITEHing KA, Merry JC, Gibson IR, Di-Silvio L, Best SM, Bonfield W
Proceedings of the 12th International Symposium on Ceramics in Medicine.
01-10-1999
Quantification of bone ingrowth within bone-derived porous hydroxyapatite implants of varying densityHing KA, Best SM, Tanner KE, Bonfield W, Revell PA
J Mater Sci-Mater M vol. 10 (10-11), 663-670.
01-10-1999
Characterization of porous hydroxyapatiteHing KA, Best SM, Bonfield W
J Mater Sci-Mater M vol. 10 (3), 135-145.
01-03-1999
Macroporous hydroxyapatites: Potential drug delivery systemsDi Silvio L, Hing K, Bonfield W
Proceedings of The Controlled Release Society (26), 1152-1153.
01-01-1999
1998
Histomorphological and biomechanical characterization of calcium phosphates in the osseous environmentHing KA, Best SM, Tanner KE, Revell PA, Bonfield W
P I Mech Eng H vol. 212 (H6), 437-451.
01-01-1998
Prize-winning peeks at the microscopic worldHing K, Knight M
01-01-1998
A degradable drug delivery system for orthopaedic applicationDi Silvio L, Hing K, Bonfield W
01-01-1998
1997
Biomechanical assessment of bone ingrowth in porous hydroxyapatiteHing KA, Best SM, Tanner KE, Bonfield W, Revell PA
Journal of Materials Science-Materials in Medicine vol. 8 (12), 731-736.
01-12-1997
Effect of fluoride substitution of the biocompatibility of hydroxyapatiteHing KA, Di-Silvio L, Gibson IR, Ohtsuki C, Jha LJ, Best SM, Bonfield W
01-01-1997
Biological evaluation of glass reinforced hydroxyapatite by flow cytometryLopes MA, Knowles JC, Hing KA, Santos JD, Monteiro FJ, Olsen I
01-01-1997
Osseointegration of porous hydroxyapatiteRevell PA, Hing KA, Tanner KE, Best SM, Bonfield W
01-01-1997
1996
Histomorphometric and biomechanical assessment of bone ingrowth in porous hydroxyapatiteHing KA, Best SM, Revell PA, Tanner KE, Bonfield W
Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 2
01-12-1996
Assessment of porous hydroxyapatite for bone replacementHING KA
01-01-1996
Hematite Nanorods as a Platform for Photoelectrochemical Imaging and SensingKrause S, Zhou B, Jiang Y, Guo Q, Das A, Sobrido AJ, Hing KA, Zayats AV
Grants
Grants of specific relevance to Predictive in vitro Models
RAEng Research Chair Sept 2024 KA HingKarin Hing
£209,059 Royal Academy of Engineering
28-04-2025 - 27-04-2030
3D perfusion bioreactor studentship Baxter - EPSRC DTP CASE Conversion 2021Karin Hing
£30,000 Baxter Healthcare Corporation
21-09-2021 - 20-03-2026
KTP AKT (QMUL-Lucideon) - Radio Opaque Cements and Osteoclast Testing: Traceable Bio-Remodellable CementsKarin Hing and Simon Rawlinson
£41,283 Innovate UK
25-03-2024 - 24-07-2024
KTP with Lucideon: Cell testing to assist development of novel biomaterialsKarin Hing and Simon Rawlinson
£256,237 Innovate UK
17-02-2021 - 17-02-2024
Bioresorbable bioactive composites Kick offKarin Hing and Emiliano Bilotti
£50,243 Baxter Healthcare Corporation
11-01-2021 - 22-01-2025
Bioactive bioresorbable composites for load bearing guided bone regenerationKarin Hing
£29,000 Baxter Healthcare Corporation
01-10-2020 - 30-09-2024
Development of mechanically enhanced osteoinductive synthetic bone graft substitutesKarin Hing
£87,500 Apatech Ltd
01-10-2017 - 31-03-2022
Doctoral Educational Research AgreementKarin Hing
£79,714 Baxter Healthcare Corporation
01-01-2015 - 31-03-2022





