Prof Martin Knight

Martin Knight
BEng, MSc, PhD

Professor of Mechanobiology, Dean for Research
Co-Director of the Centre for Predictive in vitro Models

School of Engineering and Materials Science
Queen Mary University of London
+44 (0)20 7882 8868
www.sems.qmul.ac.uk/m.m.knight
ORCID Google Scholar LinkedIn

Research

Inflammation, Arthritis, Cartilage, Kidney, Cancer, Bone, Synovium, Organ-on-a-chip

Underpinning Bioengineering, Cancer Models, Cardiovascular Models, Infectious Disease and Inflammation Models, Musculoskeletal Models

Interests

Prof Martin Knight is a bioengineer developing and using organ-on-a-chip technology to study human health and disease and to streamline the drug development pipeline. Much of his work examines role of mechanobiology and how this can be incorporated into in vitro models to more accurately predict in vivo behaviour. This includes work on osteoarthritis, inflammation, cardiovascular disease, cancer and kidney disease. He has secured over £12M of recent research funding, primarily in the area of organ-on-a-chip, including £7M funding for an EPSRC Centre for Doctoral Training in Next Generation Organ-on-a-chip technology.

Prof Knight is the co-Director of the Queen Mary Centre for Predictive in vitro Models, and co-directed the UK Organ-on-a-chip Technologies Network. He is active in helping to shape policy around the implementation of organ-chip technology, working with industry and other key stake holders including UK Government.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP
Hou Y, Screen HRC, Knight MM
Apl Bioengineering, Aip Publishing vol. 9 (2) 
01-06-2025
Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems
Hopkins T, Midha S, Grossemy S, Screen HRC, Wann AKT, Knight MM
Journal of Tissue Engineering, Sage Publications vol. 16 
18-04-2025

2024

Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit
Badar W, Inamdar SR, Fratzl P, Snow T, Terrill NJ, Knight MM, Gupta HS
Advanced Science, Wiley vol. 12 (1) 
11-11-2024
Air Pollution and Osteoporosis
Allen O, Knight MM, Verbruggen SW
Current Osteoporosis Reports, Springer Science and Business Media Llc vol. 22 (6), 590-598.  
20-09-2024
Data (SAXS and mechanical data) for W. Badar et al \Nonlinear Stress-induced Transformations in Collagen Fibrillar Organisation, Disorder and Strain Mechanisms In The Bone-Cartilage Unit\\
Gupta H, Snow T, Terrill N, Knight M, Badar W, Fratzl P
 
04-07-2024
Data used in the paper \Nonlinear Stress-induced Transformations in Collagen Fibrillar Organisation, Disorder and Strain Mechanisms In The Bone-Cartilage Unit\ by W. Badar et al
Gupta H, Badar W, Knight M, Terrill N, Snow T, Fratzl P
 
02-07-2024
A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer

Advanced Healthcare Materials, Wiley vol. 13 (17) 
22-03-2024

2023

A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR, Knight MM
Advanced Science, Wiley vol. 11 (2) 
15-11-2023
Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT, Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6) 
10-10-2023
Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM, Verbruggen SW
Cancers, Mdpi Ag vol. 15 (3), 635-635.  
19-01-2023

2022

Techniques for Visualization and Quantification of Primary Cilia in Chondrocytes
Meng H, Thompson CL, Coveney CR, Wann AK, Knight MM
In Methods in Molecular Biology, Springer Us 157-176.  
11-11-2022
YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N, Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 31 (5), 600-612.  
08-11-2022
Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF, Jones JL
Npj Breast Cancer, Springer Science and Business Media Llc vol. 8 (1) 
20-09-2022
Collagen pre-strain discontinuity at the bone—Cartilage interface
Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P et al.
Plos One, Public Library of Science (Plos) vol. 17 (9), e0273832-e0273832.  
15-09-2022
Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM, Lee DA
In Vitro Models, Springer Science and Business Media Llc vol. 1 (6), 405-412.  
31-08-2022
CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis
Stylianou P, Rushwan S, Wang W, Miah MA, Darweesh O, Mackinnon A, Roach KM, Hitchman CJ et al.
In Cold Spring Harbor Laboratory 
15-08-2022
BCU static scanning data sets
Gupta H, Badar W, Knight M
 
29-07-2022

2021

Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage
Inamdar SR, Prévost S, Terrill NJ, Knight MM, Gupta HS
Acta Biomaterialia, Elsevier Bv vol. 136, 314-326.  
01-12-2021
Collagen Pre-strain Discontinuity at the Cartilage - Bone Interface
Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P et al.
In Cold Spring Harbor Laboratory 
02-10-2021
Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer
Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR
 
01-07-2021
Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR, Knight MM
Cancers, Mdpi Ag vol. 13 (12), 2906-2906.  
10-06-2021
A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M et al.
Iscience, Elsevier vol. 24 (6) 
29-05-2021
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT et al.
Iscience, Elsevier vol. 24 (6) 
29-05-2021
Polycystin-2 Is Required for Chondrocyte Mechanotransduction and Traffics to the Primary Cilium in Response to Mechanical Stimulation
Thompson CL, McFie M, Chapple JP, Beales P, Knight MM
International Journal of Molecular Sciences, Mdpi Ag vol. 22 (9), 4313-4313.  
21-04-2021
Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.
Wu H, Wang Z, Liu S, Meng H, Liu S, Shelton JC, Thompson CL, Fu S et al.
Biochem Biophys Res Commun 
15-04-2021
Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM, Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers Media Sa vol. 9 
18-02-2021
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O et al.
Biorxiv.Org 
02-02-2021
Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction

Osteoarthritis and Cartilage, Elsevier Bv vol. 29 (1), 89-99.  
01-01-2021
Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer.
Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR
 
01-01-2021

2020

Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films
Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM et al.
Acs Nano, American Chemical Society (Acs) vol. 14 (9), 11029-11039.  
27-08-2020
Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Knight MM, Thorpe SD
Frontiers in Bioengineering and Biotechnology vol. 8 
01-01-2020

2019

Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β
Fu S, Meng H, Freer F, Kwon J, Shelton JC, Knight MM
Clinical Biomechanics, Elsevier vol. 79 
24-12-2019
Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage
Inamdar SR, Barbieri E, Terrill NJ, Knight MM, Gupta HS
Acta Biomaterialia, Elsevier Bv vol. 97, 437-450.  
01-10-2019
Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM et al.
Nature Communications, Springer Science and Business Media Llc vol. 10 (1) 
06-09-2019
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation

Osteoarthritis and Cartilage, Elsevier Bv vol. 27 (7), 1064-1074.  
01-07-2019
Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression
Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K et al.
Cancers, Mdpi Ag vol. 11 (5), 701-701.  
21-05-2019
An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation
Harris C, Thorpe SD, Rushwan S, Wang W, Thompson CL, Peacock JL, Knight MM, Gooptu B et al.
Journal of Biomechanics, Elsevier Bv vol. 88, 186-189.  
01-05-2019
Nanoscale Mapping Reveals Functional Differences in Ion Channels Populating the Membrane of Primary Cilia

Cellular Physiology and Biochemistry, Cell Physiol Biochem Press Gmbh and Co Kg vol. 54 (1), 15-26.  
10-01-2019
Oncometabolite induced primary cilia loss in pheochromocytoma
O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al.
Endocrine-Related Cancer, Bioscientifica vol. 26 (1), 165-180.  
01-01-2019
Transglutaminase-2 mediates stromal biomechanics in colorectal cancer
Delaine-Smith R, Wright N, Hanley CJ, Hanwell R, Bhome R, Bullock M, Drifka CR, Eliceiri KW et al.
 
01-01-2019
Lithium chloride triggers primary cilia elongation and inhibits hedgehog signalling in articular chondrocytes
Thompson CL, Poole CA, Knight MM
International Journal of Experimental Pathology vol. 100 (4), A39-A40.  
01-01-2019

2018

Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
Rowson DT, Shelton JC, Screen HRC, Knight MM
Scientific Reports, Springer Nature vol. 8 (1) 
23-07-2018
Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC
European Cells and Materials vol. 36, 142-155.  
01-07-2018
Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT
Journal of Cell Science, The Company of Biologists vol. 131 (10) 
15-05-2018
Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM et al.
Acta Biomater vol. 72, 434-446.  
09-04-2018
Investigating drivers of the tumour matrisome, and their role in disease progression
Pearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM et al.
 
01-01-2018

2017

Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.
Cancer Discov 
01-12-2017
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling
Thompson CL, Plant JCT, Wann AKT, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP et al.
European Cells and Materials, Forum Multimedia Publishing Llc vol. 34, 128-141.  
20-09-2017
The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization during Physiological Loading of Cartilage
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM, Gupta HS
Acs Nano, American Chemical Society (Acs) vol. 11 (10), 9728-9737.  
17-08-2017
Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis
Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA et al.
Acta Biomaterialia, Elsevier Bv vol. 57, 487-497.  
01-07-2017
Abstract 5558: Deconstruction of a human tumor microenvironment
Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M
 
01-07-2017
P07 Interleukin response to cyclical mechanical stretch with models of different neonatal ventilation modes
Harris C, Rushwan S, Wang W, Thorpe S, Thompson C, Peacock J, Knight M, Gooptu B et al.
Royal College of Paediatrics and Child Health, Abstracts of the Annual Conference, 24–26 May 2017, ICC, Birmingham. 
01-05-2017
Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria
Thorpe SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A, Knight MM
Journal of Cellular Physiology, Wiley vol. 232 (9), 2407-2417.  
31-03-2017
Smoothened‐antagonists reverse homogentisic acid‐induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria
Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL et al.
Journal of Cellular Physiology, Wiley vol. 232 (11), 3103-3111.  
29-03-2017
A Cd98hc-Dependent Mechanism Mediates Pro-Inflammatory Cytokine Release In Cell And Animal Models Of Lung Injury
Gooptu B, Rushwan S, Wang W, Harris C, Thorpe S, Knight M, Sethi T
 
01-01-2017
Polycystins are required for primary cilia-mediated mechanotransduction in chondrocytes
Thompson CL, Chapple JP, Beales PL, Mitchison HM, Ramachandran M, Knight MM
 
01-01-2017
Primary cilia mechanobiology
Knight MM
 
01-01-2017
Cyclic loading leads to primary cilia disassembly in human tenocytes
Rowson DT, Knight MM, Screen HRC
 
01-01-2017

2016

Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics
Delaine-Smith RM, Burney S, Balkwill FR, Knight MM
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier Bv vol. 60, 401-415.  
01-07-2016
Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion
Sliogeryte K, Botto L, Lee DA, Knight MM
Osteoarthritis and Cartilage, Elsevier Bv vol. 24 (5), 912-920.  
01-05-2016
Chondrocyte dedifferentiation down regulates mechano-responsiveness and hedgehog signalling associated with changes in primary cilia structure
Kelly T-AN, Thompson CL, Tan E, Wann AK, Thorpe SD, Chapple JP, Hung CT, Knight MM
 
01-04-2016
Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria
Thorpe SD, Gambassi S, Patel R, Santucci A, Knight MM
 
01-04-2016
Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.
Rowson D, Knight MM, Screen HRC
J Orthop Res vol. 34 (12), 2146-2153.  
23-03-2016
IFT88 influences chondrocyte actin organization and biomechanics

Osteoarthritis and Cartilage, Elsevier Bv vol. 24 (3), 544-554.  
01-03-2016
Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N, Knight MM
Journal of Biomechanics, Elsevier Bv vol. 49 (2), 310-317.  
01-01-2016
Physiology of urethral flow
Knight M, Buchholz N, Bourdoumis A
In Handbook of Urinary Stents: Basic Science and Clinical Applications, Jaypee Brothers Medical Publishers (P) Ltd. 219-219.  
01-01-2016

2015

Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult
Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL et al.
Arthritis Research &Amp; Therapy, Springer Science and Business Media Llc vol. 17 (1) 
01-12-2015
Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β
Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP, Knight MM
Arthritis Research &Amp; Therapy, Springer Science and Business Media Llc vol. 17 (1) 
01-12-2015
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Thompson CL, Wiles A, Poole CA, Knight MM
The Faseb Journal, Wiley vol. 30 (2), 716-726.  
23-10-2015
FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD
CHEN J, BADER DL, LEE DA, KNIGHT MM
Journal of Mechanics in Medicine and Biology, World Scientific Pub Co Pte Lt vol. 15 (05), 1550077-1550077.  
01-10-2015
Lithium chloride prevents interleukin‐1β induced cartilage degradation and loss of mechanical properties
Thompson CL, Yasmin H, Varone A, Wiles A, Poole CA, Knight MM
Journal of Orthopaedic Research, Wiley vol. 33 (10), 1552-1559.  
29-07-2015
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM
Stem Cells, Oxford University Press (Oup) vol. 33 (6), 1952-1961.  
21-05-2015
The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes

Osteoarthritis and Cartilage, Elsevier Bv vol. 23 (2), 289-299.  
01-02-2015

2014

Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics
Sliogeryte K, Thorpe SD, Lee DA, Botto L, Knight MM
Scientific Reports, Springer Science and Business Media Llc vol. 4 (1) 
04-12-2014
89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix
Rowson D, Knight M, Screen H
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a58-a59.  
01-09-2014
The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity
Wann AKT, Chapple JP, Knight MM
Cellular Signalling, Elsevier Bv vol. 26 (8), 1735-1742.  
01-08-2014
In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model
Shaheen T, Edirisinghe T, Gabriel M, Bourdoumis A, Buchholz N, Knight M
Urolithiasis, Springer Science and Business Media Llc vol. 42 (3), 203-207.  
18-03-2014
Quantification of chromatin condensation level by image processing
Irianto J, Lee DA, Knight MM
Medical Engineering &Amp; Physics, Elsevier Bv vol. 36 (3), 412-417.  
01-03-2014
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes
Thompson CL, Chapple JP, Knight MM
Osteoarthritis and Cartilage, Elsevier Bv vol. 22 (3), 490-498.  
01-03-2014
Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage
Irianto J, Ramaswamy G, Serra R, Knight MM
Journal of Biomechanics, Elsevier Bv vol. 47 (2), 579-582.  
01-01-2014

2013

Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP
Plos One, Public Library of Science (Plos) vol. 8 (12) 
30-12-2013
Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells
McMurray RJ, Wann AKT, Thompson CL, Connelly JT, Knight MM
Scientific Reports, Springer Science and Business Media Llc vol. 3 (1) 
18-12-2013
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium
Wann AKT, Thompson CL, Chapple JP, Knight MM
Cilia, Springer Science and Business Media Llc vol. 2 (1) 
01-12-2013
Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP
Plos One, Public Library of Science (Plos) vol. 8 (10), e74604-e74604.  
09-10-2013
Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?
Shafat M, Rajakumar K, Syme H, Buchholz N, Knight MM
Urolithiasis, Springer Science and Business Media Llc vol. 41 (6), 481-486.  
05-10-2013
Bardet–Biedl syndrome proteins control the cilia length through regulation of actin polymerization
Hernandez-Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M, Beales PL
Human Molecular Genetics, Oxford University Press (Oup) vol. 22 (19), 3858-3868.  
27-05-2013
The role of primary cilia in cartilage health and disease
Knight MM
 
01-04-2013
Osmotic Challenge Drives Rapid and Reversible Chromatin Condensation in Chondrocytes
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA
Biophysical Journal, Elsevier Bv vol. 104 (4), 759-769.  
01-02-2013
Super-resolution imaging strategies for Cell Biologists using a spinning disk microscope
Hosny NA, Song M, Knight MM, Wheeler AP
Molecular Biology of The Cell vol. 24 
01-01-2013

2012

Heat shock induces rapid resorption of primary cilia
Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL, Chapple JP
Development, The Company of Biologists vol. 139 (24), e2408-e2408.  
15-12-2012
Heat-shock induces rapid resorption of primary cilia
Thompson CL, Prodromou NV, Osborn DP, Ashworth R, Knight MM, Beales PL, Chapple JP
Cilia, Springer Science and Business Media Llc vol. 1 (S1) 
01-11-2012
Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes
Thompson CL, Chapple JP, Knight MM
Cilia, Springer Science and Business Media Llc vol. 1 (S1) 
01-11-2012
Topographical regulation of primary cilia orientation and length in mesenchymal stem cells
McMurray R, Knight MM
Cilia, Springer Science and Business Media Llc vol. 1 (S1) 
01-11-2012
A role for IFT88/the primary cilium in the inflammatory response to interleukin-1
Wann AKT, Knight MM
Cilia, Springer Science and Business Media Llc vol. 1 (S1) 
01-11-2012
Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation
Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M, Beales PL
Cilia, Springer Science and Business Media Llc vol. 1 (S1) 
01-11-2012
The primary cilium conducts chondrocyte mechanotransduction
Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR, Knight MM
Cilia, Springer Science and Business Media Llc vol. 1 (S1) 
01-11-2012
The Shape of the Urine Stream — From Biophysics to Diagnostics
Wheeler APS, Morad S, Buchholz N, Knight MM
Plos One, Public Library of Science (Plos) vol. 7 (10), e47133-e47133.  
16-10-2012
Viscoelastic Cell Mechanics and Actin Remodelling Are Dependent on the Rate of Applied Pressure
Pravincumar P, Bader DL, Knight MM
Plos One, Public Library of Science (Plos) vol. 7 (9), e43938-e43938.  
11-09-2012
Cell Mechanics, Structure, and Function Are Regulated by the Stiffness of the Three-Dimensional Microenvironment
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL, Knight MM
Biophysical Journal, Elsevier Bv vol. 103 (6), 1188-1197.  
01-09-2012
Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: A case study
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL, Stevens MM
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier Bv vol. 11, 72-81.  
01-07-2012
PRESSURE RATE SENSITIVE VISCOELASTIC CELL DEFORMATION INVOLVES ACTIN REMODELLING
Pravincumar P, Bader D, Knight M
Journal of Biomechanics, Elsevier Bv vol. 45, S423-S423.  
01-07-2012
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response
Wann AKT, Knight MM
Cellular and Molecular Life Sciences, Springer Science and Business Media Llc vol. 69 (17), 2967-2977.  
06-04-2012
Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids.
Gladman SJ, Huang W, Lim S-N, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV et al.
J Neurosci vol. 32 (2), 563-571.  
11-01-2012
Primary cilia mediate mechanotransduction through control of ATP‐induced Ca2+signaling in compressed chondrocytes
Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR, Knight MM
The Faseb Journal, Wiley vol. 26 (4), 1663-1671.  
05-01-2012
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA
Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.  
01-01-2012
Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations
Hosny NA, Lee DA, Knight MM
Journal of Biomedical Optics, Spie-Intl Soc Optical Eng vol. 17 (1), 016007-016007.  
01-01-2012
Heat shock induces rapid resorption of primary cilia
Prodromou NV, Thompson C, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL, Chapple JP
Journal of Cell Science, The Company of Biologists 
01-01-2012
The Role of the Primary Cilium in Chondrocyte Response to Mechanical Loading
Wann AKT, Thompson C, Knight MM
In Mechanically Gated Channels and Their Regulation, Springer Netherlands 405-426.  
01-01-2012
Topographical regulation of primary cilia orientation and length in mesenchymal stem cells
McMurray R, Knight MM
Cilia vol. 1 (Suppl 1), P34-P34.  
01-01-2012
Heat-shock induces rapid resorption of primary cilia
Thompson CL, Prodromou NV, Osborn DP, Ashworth R, Knight MM, Beales PL, Chapple JP
Cilia vol. 1 (Suppl 1), P52-P52.  
01-01-2012

2011

Omega-3 fatty acids and acute neurological trauma: a perspective on clinical translation*
Gladman S, Lim S-N, Dyall S, Knight MM, Priestley JV, Michael-Titus AT
OléAgineux Corps Gras Lipides, Edp Sciences vol. 18 (6), 317-323.  
01-11-2011
E84 Can Shockwave lithotripsy remove encrustation from ureteric nitinol stents?
Gabriel CEL, Nedilko T, Paulose PA, Bach C, Buchholz N, Knight MM
European Urology Supplements, Elsevier Bv vol. 10 (7), 482-482.  
01-10-2011
E70 The influence of extracorporeal shock wave lithotripsy on tissue viability around metallic ureteral stents
Edirisinghe TY, Knight MM, Buchholz N, Bach C
European Urology Supplements, Elsevier Bv vol. 10 (7), 477-477.  
01-10-2011
E189 Does the composition of feline urine prevent calcium oxalate encrustation of urethral stents?
Shafat M, Nedilko T, Syme H, Buchholz N, Knight MM
European Urology Supplements, Elsevier Bv vol. 10 (7), 517-518.  
01-10-2011
E75 Comparison of encrustation rates between ureteric metal stents and Double J stents
Nedilko T, Paulose PA, Buchholz N, Knight MM
European Urology Supplements, Elsevier Bv vol. 10 (7), 479-479.  
01-10-2011
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading

Biomechanics and Modeling in Mechanobiology, Springer Science and Business Media Llc vol. 11 (3-4), 439-447.  
25-06-2011
Stem Cell Mechanobiology
Lee DA, Knight MM, Campbell JJ, Bader DL
J Cell Biochem vol. 112 (1), 1-9.  
01-01-2011

2010

The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro.
Gladman SJ, Ward RE, Michael-Titus AT, Knight MM, Priestley JV
Neuroscience vol. 171 (2), 577-587.  
01-12-2010
The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures
Vaughan NM, Grainger J, Bader DL, Knight MM
Med Biol Eng Comput vol. 48 (12), 1215-1222.  
01-12-2010
Both Superficial and Deep Zone Articular Chondrocyte Subpopulations Exhibit the Crabtree Effect But Have Different Basal Oxygen Consumption Rates
Heywood HK, Knight MM, Lee DA
J Cell Physiol vol. 223 (3), 630-639.  
01-06-2010
Mechanical loading modulates chondrocyte primary cilia incidence and length
McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S, Poole CA
Cell Biol Int vol. 34 (5), 441-446.  
01-05-2010
A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles

The Faseb Journal, Wiley vol. 24 (S1) 
01-04-2010
Cyclic Loading Opens Hemichannels to Release ATP as Part of a Chondrocyte Mechanotransduction Pathway
Garcia M, Knight MM
J Orthop Res vol. 28 (4), 510-515.  
01-04-2010
Measuring the biomechanical properties of cartilage cells
Bader DL, Knight MM
, Elsevier, 106-136.  
01-01-2010
Contributor contact details
Archer C, Ralphs J, Säämänen A-M, Arokoski JPA, Jurvelin JS, Kiviranta I, Hinz B, Hunziker EB et al.
In Regenerative Medicine and Biomaterials For The Repair of Connective Tissues, Elsevier xiii-xvii.  
01-01-2010
4 Measuring the biomechanical properties of cartilage cells
Bader DL, Knight MM
In Regenerative Medicine and Biomaterials For The Repair of Connective Tissues, Elsevier 106-136.  
01-01-2010
1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)

Seibutsu Butsuri, Biophysical Society of Japan vol. 50 (supplement2), S79-S79.  
01-01-2010
Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.
Wann AKT, Mistry J, Blain EJ, Michael-Titus AT, Knight MM
Arthritis Res Ther vol. 12 (6) 
01-01-2010

2009

Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium?
Knight MM, McGlashan SR, Garcia M, Jensen CG, Poole CA
J Anat vol. 214 (2), 275-283.  
01-02-2009

2008

Biomechanical analysis of structural deformation in living cells
Bader DL, Knight MM
Med Biol Eng Comput vol. 46 (10), 951-963.  
01-10-2008
Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes
Pingguan-Murphy B, Knight MM
In Mechanosensitive Ion Channels, Springer Netherlands 235-251.  
01-01-2008

2007

An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers
Campbell JJ, Knight MM
Microsc Res Techniq vol. 70 (12), 1034-1040.  
01-12-2007
Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
Campbell JJ, Blain EJ, Chowdhury TT, Knight MM
Biochem Bioph Res Co vol. 361 (2), 329-334.  
21-09-2007
Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
KNIGHT MM, Chowdhury TT, Campbell JJ, Blain EJ
Biochemical and Biophysical Research Communications vol. 361 (21), 329-334.  
01-09-2007

2006

Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression
Chowdhury TT, Knight MM
J Cell Physiol vol. 209 (3), 845-853.  
01-12-2006
Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner
Pingguan-Murphy B, El-Azzeh M, Bader DL, Knight MM
J Cell Physiol vol. 209 (2), 389-397.  
01-11-2006
Ultrastructure of insect and spider cocoon silks
Hakimi O, Knight DP, Knight MM, Grahn MF, Vadgama P
Biomacromolecules vol. 7 (10), 2901-2908.  
09-10-2006
Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm
Bomzon Z, Knight MM, Bader DL, Kimmel E
J Biomech Eng-T Asme vol. 128 (5), 674-679.  
01-10-2006
Chondrocyte Deformation Induces Mitochondrial Distortion and Heterogeneous Intracellular Strain Fields
Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA, Bader DL
Biomechanics and Modeling in Mechanobiology, Springer Science and Business Media Llc vol. 5 (2-3), 180-191.  
07-03-2006
Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose
Knight MM, Toyoda T, Lee DA, Bader DL
J Biomech vol. 39 (8), 1547-1551.  
01-01-2006
Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration
Ohashi T, Hagiwara M, Bader DL, Knight MM
Biorheology vol. 43 (3-4), 201-214.  
01-01-2006
Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2)
Bader DL, Lee DA, Knight MM
The Proceedings of The Bioengineering Conference Annual Meeting of Bed/Jsme, Japan Society of Mechanical Engineers vol. 2005.18, 2-3.  
01-01-2006
Probing mechanical heterogeneity in chondrocytes using passive microtheology
Bomzon Z, Knight MM, Bader DL, Kimmel E
Journal of Biomechanics, Elsevier Bv vol. 39, S230-S230.  
01-01-2006

2005

Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles
Pingguan-Murphy B, Lee DA, Bader DL, Knight MM
Arch Biochem Biophys vol. 444 (1), 45-51.  
01-12-2005

2004

Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.
Sawae Y, Shelton JC, Bader DL, Knight MM
Ann Biomed Eng vol. 32 (6), 860-870.  
01-06-2004
Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage
Holloway I, Kayser M, Lee DA, Bader DL, Bentley G, Knight MM
Osteoarthr Cartilage vol. 12 (1), 17-24.  
01-01-2004
Mechanical Loading of Chondrocytes Embedded in 3D Constructs
Lee DA, Knight MM
In Cartilage and Osteoarthritis, Springer Nature 307-324.  
01-01-2004

2003

Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death
Knight MM, Roberts SR, Lee DA, Bader DL
Am J Physiol-Cell Ph vol. 284 (4), C1083-C1089.  
01-04-2003
Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear.
Bader DL, SHELTON JC, Knight MM, Sawae Y
J Biochemical Engineering Asme 
01-01-2003

2002

Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose
Knight MM, Toyoda T, Bader DL, Lee DA
 
01-12-2002
Light-induced calcium signalling in chondrocytes
Knight MM, Roberts SR, Lee DA, Bader DL
 
01-12-2002
Changes in cell morphology and cytoskeletal organisation in osteoarthric cartilage
Holloway I, Knight MM, Lee DA, Bader DL, Bentley G
 
01-09-2002
Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus
Knight MM, Bravenboer JVDB, Lee DA, van Osch GJVM, Weinans H, Bader DL
Bba-Gen Subjects vol. 1570 (1), 1-8.  
15-02-2002
Light-induced calcium signalling in chondrocytes.
Knight MM, Roberts SR, LEE DA, Bader DL
TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society University of Glasgow, Scotland 19 Sep 2002 - 20 Sep 2002. 
01-01-2002
Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.
Knight MM, Toyoda T, LEE DA, Bader DL
48th Annual Meeting of the Orthopaedic Research Society. 
01-01-2002
Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage.
Holloway I, Knight MM, LEE DA, Bader DL, Bentley G
48th Annual Meeting of the Orthopaedic Research Society. 
01-01-2002
Deformation properties of articular chondrocytes: A critique of three separate techniques
Bader DL, Ohashi T, Knight MM, Lee DA, Sato M
 
01-01-2002

2001

Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose
Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL, Poole CA
Bba-Gen Subjects vol. 1526 (2), 141-146.  
03-05-2001
Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique
Knight MM, Idowu BD, Lee DA, Bader DL
Med Biol Eng Comput vol. 39 (3), 397-404.  
01-05-2001
Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs
Roberts SR, Knight MM, Lee DA, Bader DL
J Appl Physiol vol. 90 (4), 1385-1391.  
01-04-2001
Compressive deformation and damage of muscle cell subpopulations in a model system
Bouten CVC, Knight MM, Lee DA, Bader DL
Ann Biomed Eng vol. 29 (2), 153-163.  
01-02-2001
Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds.
Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA, Bader DL
47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. 
01-01-2001
Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs.
LEE DA, Idowu BD, Knight MM, Bader DL
47th Annual Meeting, Orthopaedic Research Society San Francisco, California 25 Feb 2001 - 28 Feb 2001. 
01-01-2001

2000

Intracellular - CA2+ signalling in compressed chondrocyte agarose constructs
Roberts SR, Knight MM, Lee DA, Bader DL
 
01-12-2000
Compression induced cell and nucleus deformation in chondrocyte-alginate constructs
Knight MM, Van De Breevaart Bravenboer J, Bader DL, Lee DA
 
01-12-2000
Beta transition and stress-induced phase separation in the spinning of spider dragline silk
Knight DP, Knight MM, Vollrath F
Int J Biol Macromol vol. 27 (3), 205-210.  
13-06-2000
Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose
Idowu BD, Knight MM, Bader DL, Lee DA
Histochem J vol. 32 (3), 165-174.  
01-03-2000
Intracellular calcium signalling in compressed chondrocyte agarose constructs
Roberts SR, Knight MM, Lee DA, Bader DL
 
01-01-2000
Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels
Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV, Bader DL
J Biomech vol. 33 (1), 81-95.  
01-01-2000

1998

Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression
Knight MM, Ghori SA, Lee DA, Bader DL
Med Eng Phys vol. 20 (9), 684-688.  
01-11-1998
Response of chondrocyte subpopulations cultured within unloaded and loaded agarose
Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G, Bader DL
J Orthop Res vol. 16 (6), 726-733.  
01-11-1998
The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose
Knight MM, Lee DA, Bader DL
Bba-Mol Cell Res vol. 1405 (1-3), 67-77.  
21-10-1998
Prize-winning peeks at the microscopic world
Hing K, Knight M
 
01-01-1998

Mechanical Loading of Chondrocytes Embedded in 3D Constructs: In Vitro Methods for Assessment of Morphological and Metabolic Response to Compressive Strain
Lee DA, Knight MM
, Humana Press, 307-324.  

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
solid heart iconMicro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicines
Martin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council 
Grant Summary

01-10-2024 - 30-09-2027
solid heart iconEPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)
Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 Engineering and Physical Sciences Research Council 
Grant Summary

01-07-2024 - 30-09-2032
solid heart iconDevelopment of an Organ-on-a-chip model of polycystic kidney disease using CRISPR modified human kidney cell line
Martin Knight and Cleo Bishop
£39,986 Kidney Research UK 
Grant Summary

01-12-2023 - 30-11-2025
solid heart iconEpithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme 
Grant Summary

01-12-2023 - 30-11-2027
bullet iconPrecision Musculoskeletal Care
John Whiteley, Costantino Pitzalis, Martin Knight, Greg Slabaugh and Xavier Griffin
£3,343,542 National Institute for Health Research
01-12-2022 - 30-11-2027
solid heart iconIncorporating physical cues in organ-chip models
Hazel Screen and Martin Knight
£20,000 Emulate Inc.
01-10-2022 - 30-09-2026
solid heart iconHuman synovium-cartilage organ-chip for personalised surgical screening
Martin Knight and Timothy Hopkins
£311,203 Versus Arthritis
01-04-2022 - 30-06-2026
solid heart iconOrgan-on-a-chip Centre of Excellence
Martin Knight and Hazel Screen
£420,794 Emulate Inc.
20-08-2019 - 01-10-2029

solid heart iconOrgan-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacement
Hazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research 
Grant Summary

07-10-2024 - 14-03-2025
solid heart iconProduction of a Human Growth Plate Organ-Chip Model of Skeletal Development
Martin Knight, Clare Thompson and Hazel Screen
£197,923 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2023 - 31-07-2024
solid heart iconHighthroughput Light Sheet Microscopy: Imaging Across Scales
Viji Draviam Sastry, Caroline Brennan, Vidya Darbari, Jose Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023
bullet iconCorrelating structural and proteomic techniques on cartilage
Himadri Gupta and Martin Knight
£18,515 MRC Medical Research Council
24-07-2022 - 28-02-2023
bullet iconEmulate Organs-on-Chips Centre Technician
Martin Knight, Hazel Screen and Clare Thompson
£49,584 Emulate Inc.
01-01-2021 - 31-12-2023
solid heart iconOrgan-on-a-chip model of breast cancer bone metastases
Martin Knight and Oliver Pearce
£268,711 CR-UK Cancer Research UK
01-01-2021 - 30-06-2024
solid heart iconMICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Hazel Screen and Martin Knight
£473,325 MRC Medical Research Council
24-08-2020 - 24-05-2024
bullet iconEPSRC Core Equipment Call
Wen Wang, Martin Knight, Clive Parini and Isaac Abrahams
£125,000 EPSRC Engineering and Physical Sciences Research Council
13-02-2020 - 12-08-2021
bullet iconDoes the biological clock within cartilage align to diurnal patterns in activity?
David Lee, Hannah Heywood and Martin Knight
£9,954 EPSRC Engineering and Physical Sciences Research Council
01-10-2019 - 31-10-2020
bullet iconPharmaceutical modulation of cilia expression
Martin Knight
£3,000 Royal College of Surgeons
07-05-2019 - 07-11-2019
solid heart iconOrgan-on-a-chip technologies
Hazel Screen and Martin Knight
£479,339 Medical Research Council
01-08-2018 - 30-09-2022
bullet iconThe effect of cobalt ions on primary cilia in bone cells
Martin Knight and Frances Freer
£2,500 Royal College of Surgeons
01-05-2018 - 01-12-2018
bullet iconMETA-DORM - Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesions
Martin Knight
£152,740 EU Commission - Horizon 2020
01-01-2018 - 29-06-2020
bullet iconCollagen Fibrillar Network in Ageing Cartilage
Himadri Gupta and Martin Knight
£374,874 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2017 - 24-07-2023
bullet iconInnovation Fund: High-throughput Library Screen
Martin Knight
£9,960 BBSRC Biotechnology and Biological Sciences Research Council
01-09-2016 - 31-08-2018
bullet iconOsteoarthritis May Be Treated as an Environmental Ciliopathy
Martin Knight
£365,598 MRC Medical Research Council
01-09-2014 - 20-03-2020