Prof Hazel Screen

Hazel Screen

Professor of Biomedical Engineering
Co-Director of the Centre for Predictive in vitro Models
Director of the UK Organ-on-a-Chip Technologies Network

School of Engineering and Materials Science
Queen Mary University of London
www.sems.qmul.ac.uk/h.r.c.screen
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Research

musculoskeletal, mechanobiology, organ-on-a-chip, matrix, tendon, joint

Underpinning Bioengineering, Cardiovascular Models, Musculoskeletal Models

Interests

Hazel Screen is a Professor of Biomedical Engineering working with organ-chip technology to explore the aetiology of health and disease, with a particular focus on mechanically functional tissues such as those in the musculoskeletal or cardiovascular systems. She focuses on healthy and pathological tissue structure-function relationships and their impact on cell metabolism, developing new models within which to explore fundamental tissue mechanics and biology questions as well as routes to new treatments and drug development. She co-directs the UK Organ-on-a-Chip Technologies Network as well as the Centre for Predictive in vitro Models and Queen Mary & Emulate Organs-on-Chips Centre at QMUL. She plays an active role in helping to shape the field and associated policy and regulation, as well as driving her own research group, funded from a range of UKRI and charity sources.

Publications

Publications of specific relevance to Predictive in vitro Models

2023

Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM (2023). Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. Biomedical Materials (Bristol, England)  vol. 18, (6) 10.1088/1748-605X/acf976
Lake SP, Snedeker JG, Wang VM, Awad H, Screen HRC and Thomopoulos S (2023). Guidelines for ex vivo mechanical testing of tendon. Journal of Orthopaedic Research  vol. 41, (10) 2105-2113. 10.1002/jor.25647
Zamboulis DE, Marr N, Lenzi L, Birch HL, Screen HRC, Clegg PD and Thorpe CT (2023). The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging. Buck Institute For Age Research  Aging and Disease  10.14336/AD.2023.0425-1
Shivapatham G, Richards S, Bamber J, Screen H and Morrissey D (2023). Ultrasound Measurement of Local Deformation in the Human Free Achilles Tendon Produced by Dynamic Muscle-Induced Loading: A Systematic Review. Elsevier  Ultrasound in Medicine and Biology  10.1016/j.ultrasmedbio.2023.03.014
Waugh CM, Mousavizadeh R, Lee J, Screen HRC and Scott A (2023). Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats. Biomed Central  Bmc Musculoskeletal Disorders  vol. 24, (1) 10.1186/s12891-023-06375-0
Gains CC, Giannapoulos A, Zamboulis DE, Lopez-Tremoleda J and Screen HRC (2023). Development and application of a novel in vivo overload model of the Achilles tendon in rat. Journal of Biomechanics  vol. 151, 10.1016/j.jbiomech.2023.111546
Tayfur A, Şendil A, Sezik AÇ, Jean-François K, Sancho I, Le Sant G, Dönmez G, Duman M, Tayfur B, Pawson J, Uzlaşır S, Miller SC, Screen H and Morrissey D (2023). Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain patellar tendinopathy severity in jumping athletes: A case-control study. Elsevier  Physical Therapy in Sport  vol. 61, 57-65. 10.1016/j.ptsp.2023.02.009
Waugh CM, Mousavizadeh R, Lee J, Screen HRC and Scott A (2023). The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon. Wiley  Journal of Orthopaedic Research  10.1002/jor.25546
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW (2023). Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK. Cancers  vol. 15, (3) 10.3390/cancers15030635

2022

Candarlioglu PL, Dal Negro G, Hughes D, Balkwill F, Harris K, Screen H, Morgan H, David R, Beken S, Guenat O, Rowan W and Amour A (2022). Organ-on-a-chip: current gaps and future directions. Portland Press  Biochemical Society Transactions  vol. 50, (2) 665-673. 10.1042/BST20200661
Tayfur A, Sendil A, Sezik AC, Jean-François K, Sancho I, Le Sant G, Donmez G, Duman M, Tayfur B, Pawson J, Uzlasir S, Miller SC, Screen H and Morrissey D (2022). Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain severity in jumping athletes: A case–control study. Elsevier  Physiotherapy  vol. 114, e105-e106. 10.1016/j.physio.2021.12.052
Tayfur A, Zenner D, Miller SC, Screen H and Morrissey D (2022). Outcome predictors for recovery of patellar tendinopathy in jumping athletes: an international prospective cohort study. Bmj Journals  Bmj Open  10.1136/bmjsem-2022-sportskongres.9
Tayfur A, Haque A, Salles JI, Malliaras P, Screen H and Morrissey D (2022). Are Landing Patterns in Jumping Athletes Associated with Patellar Tendinopathy? A Systematic Review with Evidence Gap Map and Meta-analysis. Sports Medicine  vol. 52, (1) 123-137. 10.1007/s40279-021-01550-6

2021

Zahradnik TM, Cresswell M, Squier K, Waugh C, Brunham L, Screen H and Scott A (2021). Can Achilles tendon xanthoma be distinguished from Achilles tendinopathy using Dixon method MRI? A cross-sectional exploratory study. Bmc Musculoskeletal Disorders  vol. 22, (1) 10.1186/s12891-021-04494-0
Squier K, Scott A, Hunt MA, Brunham LR, Wilson DR, Screen H and Waugh CM (2021). The effects of cholesterol accumulation on Achilles tendon biomechanics: A crosssectional study. Plos One  vol. 16, (9 September) 10.1371/journal.pone.0257269
Patel D, Zamboulis DE, Spiesz EM, Birch HL, Clegg PD, Thorpe CT and Screen HRC (2021). Structure-function specialisation of the interfascicular matrix in the human achilles tendon. Acta Biomaterialia  vol. 131, 381-390. 10.1016/j.actbio.2021.07.019
Waugh C, Mousavizadeh R, Screen H and Scott A (2021). The Impact of Hypercholesterolemia on Tendon Injury Repair. Wiley  The Faseb Journal  vol. 35, (S1) 10.1096/fasebj.2021.35.s1.02060
Godinho MSC, Thorpe CT, Greenwald SE and Screen H (2021). Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix. Elsevier  Acta Biomaterialia  10.1016/j.actbio.2021.01.030

2020

Zamboulis D, Thorpe CT, Ashraf Kharaz Y, Birch HL, Clegg PD and Screen H (2020). Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix. Elife Sciences Publications Ltd  Elife  10.7554/eLife.58075
Gains C, Correia J, Baan G, Noort W, Screen H and Maas H (2020). Force Transmission Between the Gastrocnemius and Soleus Sub-Tendons of the Achilles Tendon in Rat. Frontiers Media  Frontiers in Bioengineering and Biotechnology  vol. 8, 700-700. 10.3389/fbioe.2020.00700
Tayfur A, Salles JI, Miller SC, Screen H and Morrissey D (2020). Patellar tendinopathy outcome predictors in jumping athletes: feasibility of measures for a cohort study. Physical Therapy in Sport  vol. 44, 75-84. 10.1016/j.ptsp.2020.05.004
Shearer T, Parnell WJ, Lynch B, Screen HRC and Abrahams ID (2020). A recruitment model of tendon viscoelasticity that incorporates fibril creep and explains strain-dependent relaxation. Journal of Biomechanical Engineering  vol. 142, (7) 10.1115/1.4045662
Siebert T, Screen HRC and Rode C (2020). Computational modelling of muscle, tendon, and ligaments biomechanics. Computational Modelling of Biomechanics and Biotribology in The Musculoskeletal System: Biomaterials and Tissues  10.1016/B978-0-12-819531-4.00008-0

2019

Chineye U, Jones E, Riley G, Morrissey D and Screen H (2019). An in vitro investigation into the effects of 10Hz cyclic loading on tenocyte metabolism. Wiley  Scandinavian Journal of Medicine and Science in Sports  10.1111/sms.13465
Capilnasiu A, Hadjicharalambous M, Fovargue D, Patel D, Holub O, Bilston L, Screen H, Sinkus R and Nordsletten D (2019). Magnetic resonance elastography in nonlinear viscoelastic materials under load. Biomechanics and Modeling in Mechanobiology  vol. 18, (1) 111-135. 10.1007/s10237-018-1072-1
Anssari-Benam A, Screen HRC and Bucchi A (2019). Insights into the micromechanics of stress-relaxation and creep behaviours in the aortic valve. J Mech Behav Biomed Mater  vol. 93, 230-245. 10.1016/j.jmbbm.2019.02.011

2018

Rowson DT, Shelton JC, Screen HRC and Knight MM (2018). Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6. Scientific Reports  vol. 8, (1) 10.1038/s41598-018-29502-7
Liu R, Becer CR and Screen HRC (2018). Guided Cell Attachment via Aligned Electrospinning of Glycopolymers. Macromolecular Bioscience  vol. 18, (12) 10.1002/mabi.201800293
Cook JL and Screen HR (2018). Tendon pathology: Have we missed the first step in the development of pathology? J Appl Physiol (1985)  10.1152/japplphysiol.00002.2018
Clegg P, Zamboulis D and Screen H (2018). Postnatal Development of the Functional Specialization of the Equine Superficial Digital Flexor Tendon. Thieme  Veterinary and Comparative Orthopaedics and Traumatology  vol. 31, (S 02) a1-a25. 10.1055/s-0038-1668213
PATEL D, Sharma S, SCREEN HRC and BRYANT S (2018). Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel. Elsevier  Biochemical and Biophysical Research Communications  10.1016/j.bbrc.2018.03.203
Spiesz EM, Thorpe CT, Thurner PJ and Screen HRC (2018). Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM). Acta Biomaterialia  vol. 70, 281-292. 10.1016/j.actbio.2018.01.034

2017

Godinho MSC, Thorpe CT, Greenwald SE and Screen HRC (2017). Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing. Scientific Reports  vol. 7, (1) 10.1038/s41598-017-09995-4
Shearer T, Thorpe CT, Spiesz E and SCREEN HRC (2017). The relative compliance of energy-storing tendons may be due to the helical fibril arrangement of their fascicles. Royal Society, The  Journal of The Royal Society Interface  10.1098/rsif.2017.0261
Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2017). Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons. Acta Biomaterialia  vol. 56, 58-64. 10.1016/j.actbio.2017.03.024
BECER CR, Screen HRC, Patel D and Liu R (2017). A2B-Miktoarm Glycopolymer Fibers and Their Interactions with Tenocytes. American Chemical Society  Bioconjugate Chemistry  10.1021/acs.bioconjchem.7b00279
Patel D, Sharma S, Bryant SJ and Screen HRC (2017). Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response. Advanced Healthcare Materials  vol. 6, (4) 10.1002/adhm.201601095
Elyasigomari V, Lee DA, Screen HRC and SHAHEED MH (2017). Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification. Journal of Biomedical Informatics  vol. 67, (2017) 11-20. 10.1016/j.jbi.2017.01.016
Anssari-Benam A, Bucchi A, SCREEN HRC and Evans SL (2017). A transverse isotropic viscoelastic constitutive model for aortic valve tissue. Royal Society, The: Open Access  Royal Society Open Science  10.1098/rsos.160585
Gupta HS and Screen HRC (2017). Structural building blocks of soft tissues: Tendons and heart valves. Cism International Centre For Mechanical Sciences, Courses and Lectures  10.1007/978-3-319-45071-1_1

2016

Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2016). Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons. Acta Biomaterialia  vol. 42, 308-315. 10.1016/j.actbio.2016.06.012
Handsfield GG, Slane LC and Screen HRC (2016). Nomenclature of the tendon hierarchy: An overview of inconsistent terminology and a proposed size-based naming scheme with terminology for multi-muscle tendons. Journal of Biomechanics  vol. 49, (13) 3122-3124. 10.1016/j.jbiomech.2016.06.028
Mozdzen L, Thorpe S, SCREEN HRC and Harley B (2016). The effect of gradations in mineral content, matrix alignment, and applied strain on human mesenchymal stem cell morphology within collagen biomaterials. Wiley: 12 Months  Advanced Healthcare Materials  10.1002/adhm.201600181
Thorpe CT, Karunaseelan KJ, Ng Chieng Hin J, Riley GP, Birch HL, Clegg PD and Screen HRC (2016). Distribution of proteins within different compartments of tendon varies according to tendon type. Journal of Anatomy  vol. 229, (3) 450-458. 10.1111/joa.12485
Rowson D, Knight MM and Screen HRC (2016). Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon. J Orthop Res  vol. 34, (12) 2146-2153. 10.1002/jor.23229
Chaudhry S, Fernando R, Screen H, Waugh C, Tucker A and Morrissey D (2016). The use of medical infrared thermography in the detection of tendinopathy: a systematic review. Physical Therapy Reviews  vol. 21, (2) 75-82. 10.1080/10833196.2016.1223575
Thorpe CT, Peffers MJ, Simpson D, Halliwell E, Screen HRC and Clegg PD (2016). Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. Scientific Reports  vol. 6, 10.1038/srep20455
Thorpe CT and Screen HRC (2016). Tendon structure and composition. Advances in Experimental Medicine and Biology  vol. 920, 3-10. 10.1007/978-3-319-33943-6_1
Godinho MSC, Screen HRC, Greenwald SE and Thorpe CT (2016). Elastin is more abundant in energy storing tendons and is localised to the tendon interfascicular matrix. International Journal of Experimental Pathology  vol. 97, (6) A3-A4.

2015

Thorpe CT, Godinho MSC, Riley GP, Birch HL, Clegg PD and Screen HRC (2015). The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons. Journal of The Mechanical Behavior of Biomedical Materials  vol. 52, 85-94. 10.1016/j.jmbbm.2015.04.009
Thorpe CT, Chaudhry S, Lei II, Varone A, Riley GP, Birch HL, Clegg PD and Screen HRC (2015). Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation. Scandinavian Journal of Medicine and Science in Sports  vol. 25, (4) e381-e391. 10.1111/sms.12333
Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD and Screen HRC (2015). Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise. Journal of Orthopaedic Research  vol. 33, (6) 889-897. 10.1002/jor.22879
Screen HRC, Berk DE, Kadler KE, Ramirez F and Young MF (2015). Tendon functional extracellular matrix. Journal of Orthopaedic Research  vol. 33, (6) 793-799. 10.1002/jor.22818
Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HRC (2015). Eccentric and concentric exercise of the triceps surae: An in vivo study of dynamic muscle and tendon biomechanical parameters. Journal of Applied Biomechanics  vol. 31, (2) 69-78. 10.1123/JAB.2013-0284
Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HRC (2015). Eccentric and Concentric Exercise of the Triceps Surae: An in Vivo Study of Dynamic Muscle and Tendon Biomechanical Parameters. J Appl Biomech  vol. 31, (2) 69-78. 10.1123/JAB.2013-0284
Mani-Babu S, Morrissey D, Waugh C, Screen H and Barton C (2015). The effectiveness of extracorporeal shock wave therapy in lower limb tendinopathy: a systematic review. Am J Sports Med  vol. 43, (3) 752-761. 10.1177/0363546514531911
Thorpe CT, Spiesz EM, Chaudhry S, Screen HRC and Clegg PD (2015). Science in brief: Recent advances into understanding tendon function and injury risk. Equine Veterinary Journal  vol. 47, (2) 137-140. 10.1111/evj.12346
Chaudhry S, Morrissey D, Woledge RC, Bader DL and Screen HRC (2015). Eccentric and concentric exercise of the triceps surae: An in vivo study of dynamic muscle and tendon biomechanical parameters. Journal of Applied Biomechanics  vol. 31, (2) 69-78. 10.1123/JAB.2013-0284
Waugh CM, Morrissey D, Jones E, Riley GP, Langberg H and Screen HRC (2015). In vivo biological response to extracorporeal shockwave therapy in human tendinopathy. European Cells and Materials  vol. 29, 268-280. 10.22203/eCM.v029a20
Elyasigomari V, Mirjafari MS, Screen HRC and Shaheed MH (2015). Cancer classification using a novel gene selection approach by meansof shuffling based on data clustering with optimization. Elsevier  Applied Soft Computing  vol. 35, (2015) 43-51. 10.1016/j.asoc.2015.06.015
Thorpe CT, Birch HL, Clegg PD and Screen HRC (2015). Tendon Physiology and Mechanical Behavior: Structure-Function Relationships. Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes  10.1016/B978-0-12-801590-2.00001-6
Thorpe CT, Birch HL, Clegg PD and Screen HRC (2015). Chapter 1 Tendon Physiology and Mechanical Behavior Structure–Function Relationships. Tendon Regeneration  Elsevier  10.1016/b978-0-12-801590-2.00001-6

2014

Shepherd JH, Riley GP and Screen HRC (2014). Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level. J Mech Behav Biomed Mater  vol. 38, 163-172. 10.1016/j.jmbbm.2014.06.005
Peffers MJ, Thorpe CT, Collins JA, Eong R, Wei TKJ, Screen HRC and Clegg PD (2014). Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation. J Biol Chem  vol. 289, (37) 25867-25878. 10.1074/jbc.M114.566554
Patel D, Bryant S, Riley G, Jones E and Screen H (2014). 78 Human Tenocyte Metabolism Under Pathological And Physiological Loading Conditions. Bmj  British Journal of Sports Medicine  vol. 48, (Suppl 2) a51-a51. 10.1136/bjsports-2014-094114.77
Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD and Screen HR (2014). 98 Early Inflammatory Response Of Tenocytes To Overload. Bmj  British Journal of Sports Medicine  vol. 48, (Suppl 2) a63-a64. 10.1136/bjsports-2014-094114.97
Thorpe C, Peffers M, Simpson D, Halliwell E, Screen H and Clegg P (2014). 104 Characterisation Of The Proteome Of The Tendon Interfascicular Matrix. Bmj  British Journal of Sports Medicine  vol. 48, (Suppl 2) a68-a68. 10.1136/bjsports-2014-094114.103
Rowson D, Knight M and Screen H (2014). 89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix. Bmj  British Journal of Sports Medicine  vol. 48, (Suppl 2) a58-a59. 10.1136/bjsports-2014-094114.88
Morrissey D, Morton S, Anuj CA and Screen H (2014). Achillessehnentendinopathie. Thieme  Sportphysio  vol. 02, (03) 105-111. 10.1055/s-0034-1387914
Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2014). Effect of fatigue loading on structure and functional behaviour of fascicles from energy-storing tendons. Acta Biomater  vol. 10, (7) 3217-3224. 10.1016/j.actbio.2014.04.008
Waugh C, Jones E, Riley G, Langberg H, Morrissey D and Screen H (2014). The effects of extracorporeal shockwave therapy on matrix metalloprotease activity in tendinopathy (1046.8). Wiley  The Faseb Journal  vol. 28, (S1) 10.1096/fasebj.28.1_supplement.1046.8
Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2014). Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading. Journal of The Royal Society Interface  vol. 11, (92) 10.1098/rsif.2013.1058
Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP and Screen HRC (2014). Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour. Proc Inst Mech Eng H  vol. 228, (1) 49-59. 10.1177/0954411913509977
Smith R, McIlwraith W, Schweitzer R, Kadler K, Cook J, Caterson B, Dakin S, Heinegard D, Screen H, Stover S, Crevier-Denoix N, Clegg P, Collins M, Little C, Frisbie D, Kjaer M, van Weeren R, Werpy N, Denoix J-M, Carr A, Goldberg A, Bramlage L, Smith M and Nixon A (2014). Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal  vol. 46, (1) 4-9. 10.1111/evj.12128

2013

Thorpe CT, Birch HL, Clegg PD and Screen HRC (2013). The role of the non-collagenous matrix in tendon function. Int J Exp Pathol  vol. 94, (4) 248-259. 10.1111/iep.12027
Shepherd JH and Screen HRC (2013). Fatigue loading of tendon. Int J Exp Pathol  vol. 94, (4) 260-270. 10.1111/iep.12037
Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD and Screen HRC (2013). Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return. Acta Biomater  vol. 9, (8) 7948-7956. 10.1016/j.actbio.2013.05.004
Legerlotz K, Riley GP and Screen HRC (2013). GAG depletion increases the stress-relaxation response of tendon fascicles, but does not influence recovery. Acta Biomater  vol. 9, (6) 6860-6866. 10.1016/j.actbio.2013.02.028
Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2013). Response to letter to the editor: End effects in mechanical testing of biomaterials. Journal of Biomechanics  vol. 46, (5) 10.1016/j.jbiomech.2012.12.020
Legerlotz K, Jones GC, Screen HRC and Riley GP (2013). Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes. Scandinavian Journal of Medicine and Science in Sports  vol. 23, (1) 31-37. 10.1111/j.1600-0838.2011.01410.x
Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HR (2013). Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy? Eur Cell Mater  vol. 25, 48-60. 10.22203/ecm.v025a04
Screen HRC, Toorani S and Shelton JC (2013). Microstructural stress relaxation mechanics in functionally different tendons. Med Eng Phys  vol. 35, (1) 96-102. 10.1016/j.medengphy.2012.04.004
Screen HRC, Toorani S and Shelton JC (2013). Microstructural stress relaxation mechanics in functionally different tendons. Medical Engineering and Physics  vol. 35, (1) 96-102. 10.1016/j.medengphy.2012.04.004
Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2013). Response to letter to the editor: End effects in mechanical testing of biomaterials. Journal of Biomechanics  10.1016/j.jbiomech.2012.12.020
Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD and Screen HRC (2013). Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return. Acta Biomaterialia  vol. 9, (8) 7948-7956. 10.1016/j.actbio.2013.05.004

2012

Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HRC (2012). Specialization of tendon mechanical properties results from interfascicular differences. Journal of The Royal Society Interface  vol. 9, (76) 3108-3117. 10.1098/rsif.2012.0362
Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2012). On the specimen length dependency of tensile mechanical properties in soft tissues: gripping effects and the characteristic decay length. J Biomech  vol. 45, (14) 2481-2482. 10.1016/j.jbiomech.2012.07.016
Screen HRC and Tanner KE (2012). Structure and Biomechanics of Biological Composites. Wiley Encyclopedia of Composites  Wiley  10.1002/9781118097298.weoc015
Anssari-Benam A, Gupta HS and Screen HRC (2012). Strain transfer through the aortic valve. Journal of Biomechanical Engineering  vol. 134, (6) 10.1115/1.4006812
Morrissey D, Graham J, Screen H, Sinha A, Small C, Twycross-Lewis R and Woledge R (2012). Coronal plane hip muscle activation in football code athletes with chronic adductor groin strain injury during standing hip flexion. Manual Therapy  vol. 17, (2) 145-149. 10.1016/j.math.2011.12.003
Legerlotz K, Jones ER, Screen HRC and Riley GP (2012). Increased expression of IL-6 family members in tendon pathology. Rheumatology  vol. 51, (7) 1161-1165. 10.1093/rheumatology/kes002

2011

Screen HRC, Seto J, Krauss S, Boesecke P and Gupta HS (2011). Extrafibrillar diffusion and intrafibrillar swelling at the nanoscale are associated with stress relaxation in the soft collagenous matrix tissue of tendons. Soft Matter  vol. 7, (23) 11243-11251. 10.1039/c1sm05656e
Simms C, Screen H and Evans S (2011). Nonlinearities in soft tissue strain. J Mech Behav Biomed Mater  vol. 4, (8) 10.1016/j.jmbbm.2011.10.004
Anssari-Benam A, Bader DL and Screen HRC (2011). Anisotropic time-dependant behaviour of the aortic valve. Journal of The Mechanical Behavior of Biomedical Materials  vol. 4, (8) 1603-1610. 10.1016/j.jmbbm.2011.02.010
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc Inst Mech Eng H  vol. 225, (8) 821-830. 10.1177/0954411911406340
Morrissey D, Roskilly A, Twycross-Lewis R, Isinkaye T, Screen H, Woledge R and Bader D (2011). The effect of eccentric and concentric calf muscle training on Achilles tendon stiffness. Clinical Rehabilitation  vol. 25, (3) 238-247. 10.1177/0269215510382600
Anssari-Benam A, Bader DL and Screen HRC (2011). A combined experimental and modelling approach to aortic valve viscoelasticity in tensile deformation. J Mater Sci-Mater M  vol. 22, (2) 253-262. 10.1007/s10856-010-4210-6
Chaudhry S, Screen HRC, Woledge RC, Bader D and Morrissey D (2011). The effect of loading speed on the force frequency spectrum during eccentric & concentric calf exercise. Bmj  British Journal of Sports Medicine  vol. 45, (2) 10.1136/bjsm.2010.081554.30
Sweeney E, Chaudhury S, Screen H, Woledge R, Bader D, Maffulli N and Morrissey D (2011). The effect of eccentric and concentric loading speed on the normal achilles tendon: an in vivo biomechanical study. Bmj  British Journal of Sports Medicine  vol. 45, (2) 10.1136/bjsm.2010.081554.25
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. P I Mech Eng H  vol. 225, (H8) 821-830. 10.1177/0954411911406340

2010

Legerlotz K, Riley GP and Screen HRC (2010). Specimen dimensions influence the measurement of material properties in tendon fascicles. Journal of Biomechanics  vol. 43, (12) 2274-2280. 10.1016/j.jbiomech.2010.04.040
Screen HRC, Byers S, Lynn AD, Nguyen V, Patel D and Bryant SJ (2010). Characterization of a novel fiber composite material for mechanotransduction research of fibrous connective tissues. Advanced Functional Materials  vol. 20, (5) 738-747. 10.1002/adfm.200901711
Gupta HS, Seto J, Krauss S, Boesecke P and Screen HRC (2010). In situ multi-level analysis of viscoelastic deformation mechanisms in tendon collagen. Journal of Structural Biology  vol. 169, (2) 183-191. 10.1016/j.jsb.2009.10.002

2009

Screen HRC and Evans SL (2009). Measuring strain distributions in the tendon using confocal microscopy and finite elements. J Strain Anal Eng  vol. 44, (5) 327-335. 10.1243/03093247JSA491
SCREEN H (2009). Hierarchical approaches to understanding tendon mechanics. Japan Society of Mechanical Engineers  Journal of Biomechanical Science and Engineering  vol. 4, (4) 481-499. 10.1299/jbse.4.481

2008

Toorani S, Shelton JC and Screen HRC (2008). Characterizing structure-function relationships in tendon. 8th World Biomaterials Congress 2008  vol. 2,
Screen HRC (2008). Investigating load relaxation mechanics in tendon. Journal of The Mechanical Behavior of Biomedical Materials  vol. 1, (1) 51-58. 10.1016/j.jmbbm.2007.03.002

2007

Cheng VWT and Screen HRC (2007). The micro-structural strain response of tendon. J Mater Sci  vol. 42, (21) 8957-8965. 10.1007/s10853-007-1653-3
SCREEN HRC and Cheng VWT (2007). Strain mechanisms in tendon fascicles. J.Mat.Sci.  vol. 21, 8957-8965. 10.1007/s10853-007-1653-3

2006

Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC (2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater  vol. 2, (5) 505-513. 10.1016/j.actbio.2006.05.008

2005

Screen HRC, Bader DL, Shelton JC and Lee DA (2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of The 2005 Summer Bioengineering Conference  vol. 2005, 193-194.
Screen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun  vol. 336, (2) 424-429. 10.1016/j.bbrc.2005.08.102
Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA (2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng  vol. 33, (8) 1090-1099. 10.1007/s10439-005-5777-9
Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank S, Edwards DR, Parker AE, Clark IM, Boubriak OA, Urban JPG, Cui Z, Tew SR, Li Y, Tweats LM, Hawkins RE, Hardingham TE, Green D, Partridge KA, Leveque I, Mann S, Oreffo ROC, Ball SG, Kielty CM, Qin M, Tai G and Polak JM (2005). British society for matrix biology autumn meeting. International Journal of Experimental Pathology  vol. 86, (3) 10.1111/j.0959-9673.2005.00426.x

2004

Bader DL, Shelton JC, Lee DA and SCREEN HRC (2004). Local Strain Measurement within Tendon. Strain  vol. 40, (4) 157-163. 10.1111/j.1475-1305.2004.00164.x
Screen HRC, Lee DA, Bader DL and Shelton JC (2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proc Inst Mech Eng H  vol. 218, (2) 109-119. 10.1243/095441104322984004

2003

Screen HRC, Lee DA, Bader DL and Shelton JC (2003). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology  vol. 40, (1-3) 361-368.

2002

BADER DL, Shelton JC, Lee DA and Screen HRC (2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology  vol. 40, 361-368.
Bader DL, Shelton JC, Lee DA and SCREEN HRC (2002). Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain. Eur. Cells Mat.  vol. 4:S1, 41-42.
Bader DL, Shelton JC, LEE DA and Screen HRC (2002). Non-collagenous matrix components influence the micro-mechanical environment of tenocytes within tendon fasciles subjected to tensile strain. Eur. Cells Materials  vol. 4 suppl 1, 41-42.

Grants

Grants of specific relevance to Predictive in vitro Models
Next generation organ-chip models - integrating 3D mechano-predictive environments
Screen H and Bevan CM
Engineering and Physical Sciences Research Council (19-09-2022 - 30-03-2026)
Summary
PhD Studentship: Development of an arterial organ-chip to study the role of primary cilia in atherosclerosis
Knight MM and Screen H
China Scholarship Council (06-09-2021 - 08-09-2025)
Summary
Development of an Organ-chip Model to examine Muscle Degeneration
Knight MM, Screen H and Fazal MR
Engineering and Physical Sciences Research Council (19-09-2021 - 30-03-2025)
Summary
The interfascicular matrix niche - novel approaches to identify the aetiology of tendinopathy
Screen H and Philbrooks LA
Engineering and Physical Sciences Research Council (20-09-2020 - 31-03-2024)
Summary
Novel Models of Tendinopathy on a Chip
Screen HRC and Knight MM
ConaCyT (07-10-2019 - 06-01-2024)

Queen Mary+Emulate Organs-on-chips Centre
Screen HRC and Knight MM
£525,375 Emulate Inc and QMUL (20-09-2019 - 19-09-2023)
Summary
MICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Screen HRC, Knight MM and El Haj A
£504,557 Medical Research Council (24-08-2020 - 23-08-2023)
Summary
PhD Studentship: Investigation of synovium-cartilage pro-inflammatory cross talk and the role of primary cilia using organ-chip models
Screen HRC, Knight MM and Terrazas D
Conacyt Scholarship (16-09-2019 - 15-09-2022)
Modulating tendon micromechanics for injury prevention or management
Screen H and Gains C
Engineering and Physical Sciences Research Council (24-09-2017 - 29-09-2021)
Summary
Organ-on-a-chip Technologies
Screen HRC, Bull AMJ, Haj AJE, Knight MM, Carr AJ, Gunn JPG, Dalby MJ and Workman P
£479,338 Medical Research Council (31-07-2018 - 30-07-2021)
Summary
Identifying the causes of age-related tendon injury
Screen HRC
£190,374 Dunhill Medical Trust (01-10-2018 - 31-03-2021)
Summary
Measuring local strain distributions through the equine SDFT as a novel indication of injury risk
Screen HRC
£167,426 Horserace Betting Levy Board (01-04-2017 - 31-03-2019)
Post-natal development of the tendon inter-fascicular matrix for long-term tendon health
Screen HRC
Horserace Betting Levy Board (01-05-2015 - 30-04-2017)
The role of the inter-fascicular matrix in mediating tendon fatigue resistance: Do age related changes lead to tendinopathy?
Screen H
£173,750 Versus Arthritis (01-10-2013 - 30-09-2016)
Summary
Role of the inter-fascicular matrix in age related deterioration of tendon mechanical function
Screen HRC
£290,208 Biotechnology and Biological Sciences Research Council (30-04-2013 - 29-06-2016)
Summary
The role of high frequency loading in the treatment of tendinopathy.
Screen HRC
Orthopaedic Research UK (01-10-2012 - 30-09-2015)
Human tenocyte metabolism under physiological and pathological loading conditions
Screen H
£100,761 Versus Arthritis (03-10-2011 - 02-10-2014)
Summary
Human tenocyte metabolism under physiological & pathological loading.
Screen HRC
Arthritis Research UK (01-09-2011 - 31-08-2014)
A Multidisciplinary investigation into the mechanics and biology of developing tendinopathy.
Screen HRC and Riley GP
£192,438 Wellcome Trust (01-10-2009 - 31-01-2014)
Summary
Investigating aging in equine tendinopathy.
Screen HRC
Horserace Betting Levy Board (01-05-2010 - 30-04-2013)
Extracorporeal Shock Wave Therapy for Achilles Tendinopathy
Screen HRC
EPSRC KTA (01-05-2011 - 30-04-2013)