Prof Hazel Screen

Hazel Screen

Professor of Biomedical Engineering
Co-Director of the Centre for Predictive in vitro Models

School of Engineering and Materials Science
Queen Mary University of London
www.sems.qmul.ac.uk/h.r.c.screen
ResearcherID ORCID Google Scholar LinkedIn X

Research

musculoskeletal, mechanobiology, organ-on-a-chip, matrix, tendon, joint

Underpinning Bioengineering, Cardiovascular Models, Musculoskeletal Models

Interests

Hazel Screen is a Professor of Biomedical Engineering working with organ-chip technology to explore the aetiology of health and disease, with a particular focus on mechanically functional tissues such as those in the musculoskeletal or cardiovascular systems.
She focuses on healthy and pathological tissue structure-function relationships and their impact on cell metabolism, developing new models within which to explore fundamental tissue mechanics and biology questions as well as routes to new treatments and drug development.
She co-directs the UK Organ-on-a-Chip Technologies Network as well as the Centre for Predictive in vitro Models and Queen Mary & Emulate Organs-on-Chips Centre at QMUL. She plays an active role in helping to shape the field and associated policy and regulation, as well as driving her own research group, funded from a range of UKRI and charity sources.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems
Hopkins T, Midha S, Grossemy S, Screen HRC, Wann AKT, Knight MM
Journal of Tissue Engineering, Sage Publications vol. 16 
18-04-2025

2024

TENDON HEALTH AND DISEASE: EXPLORING THE INTERFASCICULAR NICHE
Screen HRC
Orthopaedic Proceedings, British Editorial Society of Bone & Joint Surgery vol. 106-B (SUPP_2), 105-105.  
02-01-2024

2023

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT, Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6) 
10-10-2023
Guidelines for ex vivo mechanical testing of tendon
Lake SP, Snedeker JG, Wang VM, Awad H, Screen HRC, Thomopoulos S
Journal of Orthopaedic Research®, Wiley vol. 41 (10), 2105-2113.  
26-06-2023
The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging.
Zamboulis DE, Marr N, Lenzi L, Birch HL, Screen HRC, Clegg PD, Thorpe CT
Aging and Disease, Buck Institute For Age Research 
22-05-2023
Ultrasound Measurement of Local Deformation in the Human Free Achilles Tendon Produced by Dynamic Muscle-Induced Loading: A Systematic Review.
Shivapatham G, Richards S, Bamber J, Screen H, Morrissey D
Ultrasound in Medicine and Biology, Elsevier 
04-05-2023
Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats
Waugh CM, Mousavizadeh R, Lee J, Screen HRC, Scott A
Bmc Musculoskeletal Disorders, Biomed Central vol. 24 (1) 
12-04-2023
Development and application of a novel in vivo overload model of the Achilles tendon in rat
Gains CC, Giannapoulos A, Zamboulis DE, Lopez-Tremoleda J, Screen HRC
Journal of Biomechanics, Elsevier vol. 151 
15-03-2023
Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain patellar tendinopathy severity in jumping athletes: A case-control study
Tayfur A, Şendil A, Sezik AÇ, Jean-François K, Sancho I, Le Sant G, Dönmez G, Duman M et al.
Physical Therapy in Sport, Elsevier vol. 61, 57-65.  
04-03-2023
The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon.
Waugh CM, Mousavizadeh R, Lee J, Screen HRC, Scott A
Journal of Orthopaedic Research, Wiley 
03-03-2023
Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM, Verbruggen SW
Cancers, Mdpi Ag vol. 15 (3), 635-635.  
19-01-2023

2022

Organ-on-a-chip: current gaps and future directions
Candarlioglu PL, Dal Negro G, Hughes D, Balkwill F, Harris K, Screen H, Morgan H, David R et al.
Biochemical Society Transactions, Portland Press vol. 50 (2), 665-673.  
19-04-2022
Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain severity in jumping athletes: A case–control study
Tayfur A, Sendil A, Sezik AC, Jean-François K, Sancho I, Le Sant G, Donmez G, Duman M et al.
Physiotherapy, Elsevier vol. 114, e105-e106.  
01-02-2022
Outcome predictors for recovery of patellar tendinopathy in jumping athletes: an international prospective cohort study
Tayfur A, Zenner D, Miller SC, Screen H, Morrissey D
Bmj Open, Bmj Journals 
20-01-2022
TENDON STRUCTURE FUNCTION RELATIONSHIPS: INJURY AND THE INTERFASCICULAR MATRIX
Screen H
 
01-01-2022

2021

Are Landing Patterns in Jumping Athletes Associated with Patellar Tendinopathy? A Systematic Review with Evidence Gap Map and Meta-analysis
Tayfur A, Haque A, Salles JI, Malliaras P, Screen H, Morrissey D
Sports Medicine, Springer Nature vol. 52 (1), 123-137.  
23-09-2021
The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study
Squier K, Scott A, Hunt MA, Brunham LR, Wilson DR, Screen H, Waugh CM
Plos One, Public Library of Science (Plos) vol. 16 (9) 
16-09-2021
Can Achilles tendon xanthoma be distinguished from Achilles tendinopathy using Dixon method MRI? A cross-sectional exploratory study
Zahradnik TM, Cresswell M, Squier K, Waugh C, Brunham L, Screen H, Scott A
Bmc Musculoskeletal Disorders, Springer Nature vol. 22 (1) 
16-07-2021
Structure-function specialisation of the interfascicular matrix in the human achilles tendon
Patel D, Zamboulis DE, Spiesz EM, Birch HL, Clegg PD, Thorpe CT, Screen HRC
Acta Biomaterialia, Elsevier vol. 131, 381-390.  
13-07-2021
The Impact of Hypercholesterolemia on Tendon Injury Repair
Waugh C, Mousavizadeh R, Screen H, Scott A
The Faseb Journal, Wiley vol. 35 (S1) 
01-05-2021
Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix
Godinho MSC, Thorpe CT, Greenwald SE, Screen H
Acta Biomaterialia, Elsevier 
26-01-2021
8 Computational modelling of muscle, tendon, and ligaments biomechanics
Siebert T, Screen HRC, Rode C
In Computational Modelling of Biomechanics and Biotribology in The Musculoskeletal System, Elsevier 155-186.  
01-01-2021

2020

Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix
Zamboulis D, Thorpe CT, Ashraf Kharaz Y, Birch HL, Clegg PD, Screen H
Elife, Elife Sciences Publications Ltd 
16-10-2020
Force Transmission Between the Gastrocnemius and Soleus Sub-Tendons of the Achilles Tendon in Rat
Gains C, Correia J, Baan G, Noort W, Screen H, Maas H
Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 8, 700-700.  
17-07-2020
Patellar tendinopathy outcome predictors in jumping athletes: feasibility of measures for a cohort study
Tayfur A, Salles JI, Miller SC, Screen H, Morrissey D
Physical Therapy in Sport, Elsevier vol. 44, 75-84.  
16-05-2020
A Recruitment Model of Tendon Viscoelasticity That Incorporates Fibril Creep and Explains Strain-Dependent Relaxation.
Shearer T, Parnell WJ, Lynch B, Screen HRC, David Abrahams I
Journal of Biomechanical Engineering, Asme International vol. 142 (7) 
24-02-2020

2019

An in vitro investigation into the effects of 10Hz cyclic loading on tenocyte metabolism
Chineye U, Jones E, Riley G, Morrissey D, Screen H
Scandinavian Journal of Medicine and Science in Sports, Wiley 
18-05-2019
Insights into the micromechanics of stress-relaxation and creep behaviours in the aortic valve.
Anssari-Benam A, Screen HRC, Bucchi A
J Mech Behav Biomed Mater vol. 93, 230-245.  
12-02-2019
Novel glycopolymer-based biomaterials for tissue engineering
Liu R, Screen HRC, Becer R
 
01-01-2019

2018

Guided Cell Attachment via Aligned Electrospinning of Glycopolymers
Liu R, Becer CR, Screen HRC
Macromolecular Bioscience vol. 18 (12) 
01-12-2018
Magnetic resonance elastography in nonlinear viscoelastic materials under load
Capilnasiu A, Hadjicharalambous M, Fovargue D, Patel D, Holub O, Bilston L, Screen H, Sinkus R et al.
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 18 (1), 111-135.  
27-08-2018
Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
Rowson DT, Shelton JC, Screen HRC, Knight MM
Scientific Reports, Springer Nature vol. 8 (1) 
23-07-2018
Tendon pathology: Have we missed the first step in the development of pathology?
Cook JL, Screen HR
J Appl Physiol (1985) 
01-07-2018
Postnatal Development of the Functional Specialization of the Equine Superficial Digital Flexor Tendon
Clegg P, Zamboulis D, Screen H
Veterinary and Comparative Orthopaedics and Traumatology, Thieme vol. 31 (S 02), a1-a25.  
01-07-2018
Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel
PATEL D, Sharma S, SCREEN HRC, BRYANT S
Biochemical and Biophysical Research Communications, Elsevier 
02-04-2018
Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM)
Spiesz EM, Thorpe CT, Thurner PJ, Screen HRC
Acta Biomaterialia vol. 70, 281-292.  
01-04-2018
Pre- and post-natal development of the tendon inter-fascicular matrix and fascicles in the equine superficial digital flexor tendon and common digital extensor tendon
Zamboulis DE, Thorpe CT, Birch HL, Screen HR, Clegg PD
 
01-04-2018

2017

Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing
Godinho MSC, Thorpe CT, Greenwald SE, Screen HRC
Scientific Reports vol. 7 (1) 
01-12-2017
The relative compliance of energy-storing tendons may be due to the helical fibril arrangement of their fascicles
Shearer T, Thorpe CT, Spiesz E, SCREEN HRC
Journal of The Royal Society Interface, Royal Society, The 
09-08-2017
Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons
Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HRC
Acta Biomaterialia vol. 56, 58-64.  
01-07-2017
A2B-Miktoarm Glycopolymer Fibers and Their Interactions with Tenocytes
BECER CR, Screen HRC, Patel D, Liu R
Bioconjugate Chemistry, American Chemical Society 
21-06-2017
Novel models of late onset, progressive osteoarthritis caused by point mutations in the two alpha chains of collagen type I
Blease AM, Wisby L, Haynes AR, Nicol TL, Falcone S, Lad H, Esapa CT, Horwood N et al.
 
01-04-2017
Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response
Patel D, Sharma S, Bryant SJ, Screen HRC
Advanced Healthcare Materials vol. 6 (4) 
22-02-2017
Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification
Elyasigomari V, Lee DA, Screen HRC, SHAHEED MH
Journal of Biomedical Informatics vol. 67 (2017), 11-20.  
03-02-2017
A transverse isotropic viscoelastic constitutive model for aortic valve tissue
Anssari-Benam A, Bucchi A, SCREEN HRC, Evans SL
Royal Society Open Science, Royal Society, The: Open Access 
11-01-2017
Cyclic loading leads to primary cilia disassembly in human tenocytes
Rowson DT, Knight MM, Screen HRC
 
01-01-2017
Do the sub-bundles within the Achilles tendon originating from distinct muscle bellies differ in structural and mechanical properties?
Corben DC, Notou M, Screen HRC, Birch HL
 
01-01-2017

2016

Structural Building Blocks of Soft Tissues: Tendons and Heart Valves
Gupta HS, Screen HRC
In Material Parameter Identification and Inverse Problems in Soft Tissue Biomechanics, Springer Nature 1-35.  
13-10-2016
Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons
Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HRC
Acta Biomaterialia vol. 42, 308-315.  
15-09-2016
Nomenclature of the tendon hierarchy: An overview of inconsistent terminology and a proposed size-based naming scheme with terminology for multi-muscle tendons
Handsfield GG, Slane LC, Screen HRC
Journal of Biomechanics vol. 49 (13), 3122-3124.  
06-09-2016
The effect of gradations in mineral content, matrix alignment, and applied strain on human mesenchymal stem cell morphology within collagen biomaterials
Mozdzen L, Thorpe S, SCREEN HRC, Harley B
Advanced Healthcare Materials, Wiley: 12 Months 
01-06-2016
Distribution of proteins within different compartments of tendon varies according to tendon type
Thorpe CT, Karunaseelan KJ, Ng Chieng Hin J, Riley GP, Birch HL, Clegg PD, Screen HRC
Journal of Anatomy vol. 229 (3), 450-458.  
25-04-2016
Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.
Rowson D, Knight MM, Screen HRC
J Orthop Res vol. 34 (12), 2146-2153.  
23-03-2016
The use of medical infrared thermography in the detection of tendinopathy: a systematic review
Chaudhry S, Fernando R, Screen H, Waugh C, Tucker A, Morrissey D
Physical Therapy Reviews, Taylor & Francis vol. 21 (2), 75-82.  
03-03-2016
Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition
Thorpe CT, Peffers MJ, Simpson D, Halliwell E, Screen HRC, Clegg PD
Scientific Reports, Springer Nature vol. 6 (1) 
04-02-2016
Tendon Structure and Composition
Thorpe CT, Screen HRC
Advances in Experimental Medicine and Biology, Springer Nature vol. 920, 3-10.  
01-01-2016
Energy storing and positional human tendons: mechanics and changes with ageing
Patel D, Spiesz EM, Thorpe CT, Birch HL, Riley GP, Clegg PD, Screen HRC
 
01-01-2016
Elastin is more abundant in energy storing tendons and is localised to the tendon interfascicular matrix
Godinho MSC, Screen HRC, Greenwald SE, Thorpe CT
 
01-01-2016

2015

In vivo biological response to extracorporeal shockwave therapy in human tendinopathy
Waugh CM, Morrissey D, Jones E, Riley GP, Langberg H, Screen HRC
Ecells & Materials, Forum Multimedia Publishing vol. 29, 268-280.  
15-05-2015
Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise
Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD, Screen HRC
Journal of Orthopaedic Research®, Wiley vol. 33 (6), 889-897.  
29-04-2015
Tendon Functional Extracellular Matrix
Screen HRC, Berk DE, Kadler KE, Ramirez F, Young MF
Journal of Orthopaedic Research®, Wiley vol. 33 (6), 793-799.  
29-04-2015
The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons
Thorpe CT, Godinho MSC, Riley GP, Birch HL, Clegg PD, Screen HRC
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 52, 85-94.  
16-04-2015
Eccentric and concentric exercise of the triceps surae: an in vivo study of dynamic muscle and tendon biomechanical parameters.
Chaudhry S, Morrissey D, Woledge RC, Bader DL, Screen HR
J Appl Biomech vol. 31 (2), 69-78.  
01-04-2015
Eccentric and Concentric Exercise of the Triceps Surae: An in Vivo Study of Dynamic Muscle and Tendon Biomechanical Parameters.
Chaudhry S, Morrissey D, Woledge RC, Bader DL, Screen HRC
J Appl Biomech vol. 31 (2), 69-78.  
01-04-2015
The effectiveness of extracorporeal shock wave therapy in lower limb tendinopathy: a systematic review.
Mani-Babu S, Morrissey D, Waugh C, Screen H, Barton C
Am J Sports Med vol. 43 (3), 752-761.  
01-03-2015
Science in brief: Recent advances into understanding tendon function and injury risk
Thorpe CT, Spiesz EM, Chaudhry S, Screen HRC, Clegg PD
Equine Veterinary Journal, Wiley vol. 47 (2), 137-140.  
03-02-2015
Cancer classification using a novel gene selection approach by meansof shuffling based on data clustering with optimization
Elyasigomari V, Mirjafari MS, Screen HRC, Shaheed MH
Applied Soft Computing, Elsevier vol. 35 (2015), 43-51.  
01-01-2015
Tendon Physiology and Mechanical Behavior: Structure-Function Relationships
Thorpe CT, Birch HL, Clegg PD, Screen HRC
In Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes 3-39.  
01-01-2015
Chapter 1 Tendon Physiology and Mechanical Behavior Structure–Function Relationships
Thorpe CT, Birch HL, Clegg PD, Screen HRC
In Tendon Regeneration, Elsevier 3-39.  
01-01-2015

2014

Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation
Thorpe CT, Chaudhry S, Lei II, Varone A, Riley GP, Birch HL, Clegg PD, Screen HRC
Scandinavian Journal of Medicine and Science in Sports, Wiley vol. 25 (4), e381-e391.  
30-12-2014
Eccentric and concentric loading of the triceps surae: an in vivo study of dynamic muscle and tendon biomechanical parameters.
Chaudhry S, Morrissey D, Woledge RC, Bader DL, Screen HRC
Journal of Applied Biomechanics vol. 31 (2), 69-78.  
16-10-2014
Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level.
Shepherd JH, Riley GP, Screen HRC
J Mech Behav Biomed Mater vol. 38, 163-172.  
01-10-2014
Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation.
Peffers MJ, Thorpe CT, Collins JA, Eong R, Wei TKJ, Screen HRC, Clegg PD
J Biol Chem vol. 289 (37), 25867-25878.  
12-09-2014
78 Human Tenocyte Metabolism Under Pathological And Physiological Loading Conditions
Patel D, Bryant S, Riley G, Jones E, Screen H
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a51-a51.  
01-09-2014
98 Early Inflammatory Response Of Tenocytes To Overload
Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD, Screen HR
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a63-a64.  
01-09-2014
104 Characterisation Of The Proteome Of The Tendon Interfascicular Matrix
Thorpe C, Peffers M, Simpson D, Halliwell E, Screen H, Clegg P
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a68-a68.  
01-09-2014
89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix
Rowson D, Knight M, Screen H
British Journal of Sports Medicine, Bmj vol. 48 (Suppl 2), a58-a59.  
01-09-2014
Achillessehnentendinopathie
Morrissey D, Morton S, Anuj CA, Screen H
Sportphysio, Thieme vol. 02 (03), 105-111.  
20-08-2014
Effect of fatigue loading on structure and functional behaviour of fascicles from energy-storing tendons.
Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HRC
Acta Biomater vol. 10 (7), 3217-3224.  
01-07-2014
The effects of extracorporeal shockwave therapy on matrix metalloprotease activity in tendinopathy (1046.8)
Waugh C, Jones E, Riley G, Langberg H, Morrissey D, Screen H
The Faseb Journal, Wiley vol. 28 (S1) 
01-04-2014
Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading
Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HRC
Journal of The Royal Society Interface vol. 11 (92) 
06-03-2014
Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour.
Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP, Screen HRC
Proc Inst Mech Eng H vol. 228 (1), 49-59.  
01-01-2014
Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease
Smith R, McIlwraith W, Schweitzer R, Kadler K, Cook J, Caterson B, Dakin S, Heinegard D et al.
Equine Veterinary Journal vol. 46 (1), 4-9.  
01-01-2014
Fatigue loading causes a reduction in the ability of tendon fascicles to recoil
Thorpe CT, Udeze CP, Birch HL, Clegg PD, Screen HR
 
01-01-2014
Matrix damage as a result of cyclic creep loading occurs in the absence of changes in tendon mechanics at either the gross or micro-structural level
Shepherd JH, Riley GP, Screen HRC
 
01-01-2014

2013

Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return.
Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD, Screen HRC
Acta Biomater vol. 9 (8), 7948-7956.  
01-08-2013
The role of the non-collagenous matrix in tendon function.
Thorpe CT, Birch HL, Clegg PD, Screen HRC
Int J Exp Pathol vol. 94 (4), 248-259.  
01-08-2013
Fatigue loading of tendon.
Shepherd JH, Screen HRC
Int J Exp Pathol vol. 94 (4), 260-270.  
01-08-2013
Effect of Fatigue Loading on Tendon Fascicle Extension Mechanisms
Thorpe CT, Birch HL, Clegg PD, Screen HRC
Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mech. 
26-06-2013
Energy Storing and Positional Tendon Fascicles Exhibit Different Fatigue Behaviour
Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP, Screen HRC
Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mech. 
26-06-2013
GAG depletion increases the stress-relaxation response of tendon fascicles, but does not influence recovery.
Legerlotz K, Riley GP, Screen HRC
Acta Biomater vol. 9 (6), 6860-6866.  
01-06-2013
Response to letter to the editor: End effects in mechanical testing of biomaterials
Anssari-Benam A, Legerlotz K, Bader DL, Screen HRC
Journal of Biomechanics vol. 46 (5) 
15-03-2013
Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes
Legerlotz K, Jones GC, Screen HRC, Riley GP
Scandinavian Journal of Medicine and Science in Sports vol. 23 (1), 31-37.  
01-02-2013
Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy?
Thorpe CT, Udeze CP, Birch HL, Clegg PD, Screen HR
Eur Cell Mater vol. 25, 48-60.  
08-01-2013
Microstructural stress relaxation mechanics in functionally different tendons.
Screen HRC, Toorani S, Shelton JC
Med Eng Phys vol. 35 (1), 96-102.  
01-01-2013
Microstructural stress relaxation mechanics in functionally different tendons
Screen HRC, Toorani S, Shelton JC
Medical Engineering and Physics vol. 35 (1), 96-102.  
01-01-2013
Response to letter to the editor: End effects in mechanical testing of biomaterials
Anssari-Benam A, Legerlotz K, Bader DL, Screen HRC
Journal of Biomechanics 
01-01-2013
The effects of extracorporeal shock wave therapy (ESWT) on type I collagen synthesis in the Achilles tendon: an intervention study on healthy participants
Mani-Babu S, Waugh CM, Screen HR, Maffulli N, Morrissey D
 
01-01-2013
Helical fascicles in energy storing tendons: a mechanism for efficient recoil?
Thorpe CT, Birch HL, Clegg PD, Screen HRC
 
01-01-2013
The fatigue behaviour of functionally distinct bovine tendons
Shepherd JH, Legerlotz K, Demirci T, Riley GP, Screen HRC
 
01-01-2013
The role of Interleukin-6 in the response of human hamstrings tendon to unloading, loading and overloading
Legerlotz K, Jones ER, Screen HR, Riley GP
 
01-01-2013
Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return
Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD, Screen HRC
Acta Biomaterialia vol. 9 (8), 7948-7956.  
01-01-2013

2012

Specialization of tendon mechanical properties results from interfascicular differences
Thorpe CT, Udeze CP, Birch HL, Clegg PD, Screen HRC
Journal of The Royal Society Interface vol. 9 (76), 3108-3117.  
07-11-2012
On the specimen length dependency of tensile mechanical properties in soft tissues: gripping effects and the characteristic decay length.
Anssari-Benam A, Legerlotz K, Bader DL, Screen HRC
J Biomech vol. 45 (14), 2481-2482.  
21-09-2012
Structure and Biomechanics of Biological Composites
Screen HRC, Tanner KE
In Wiley Encyclopedia of Composites, Wiley 1-12.  
20-07-2012
Strain transfer through the aortic valve
Anssari-Benam A, Gupta HS, Screen HRC
Journal of Biomechanical Engineering vol. 134 (6) 
29-06-2012
Coronal plane hip muscle activation in football code athletes with chronic adductor groin strain injury during standing hip flexion
Morrissey D, Graham J, Screen H, Sinha A, Small C, Twycross-Lewis R, Woledge R
Manual Therapy vol. 17 (2), 145-149.  
01-04-2012
THE MICRO-STRUCTURAL RESPONSE OF TENDON FASCICLES TO APPLIED MAIN IS ALTERED WITH AGEING
Thorpe CT, Birch HL, Clegg PD, Screen HR
 
01-01-2012
Increased expression of IL-6 family members in tendon pathology
Legerlotz K, Jones ER, Screen HRC, Riley GP
Rheumatology vol. 51 (7), 1161-1165.  
01-01-2012

2011

Extrafibrillar diffusion and intrafibrillar swelling at the nanoscale are associated with stress relaxation in the soft collagenous matrix tissue of tendons
Screen HRC, Seto J, Krauss S, Boesecke P, Gupta HS
Soft Matter vol. 7 (23), 11243-11251.  
07-11-2011
Nonlinearities in soft tissue strain.
Simms C, Screen H, Evans S
J Mech Behav Biomed Mater vol. 4 (8) 
01-11-2011
Anisotropic time-dependant behaviour of the aortic valve
Anssari-Benam A, Bader DL, Screen HRC
Journal of The Mechanical Behavior of Biomedical Materials vol. 4 (8), 1603-1610.  
01-11-2011
Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment.
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH, Screen HRC
Proc Inst Mech Eng H vol. 225 (8), 821-830.  
01-08-2011
Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression
Legerlotz K, Jones GC, Riley GP, Screen HRC
 
01-06-2011
The effect of eccentric and concentric calf muscle training on Achilles tendon stiffness
Morrissey D, Roskilly A, Twycross-Lewis R, Isinkaye T, Screen H, Woledge R, Bader D
Clinical Rehabilitation vol. 25 (3), 238-247.  
01-03-2011
A combined experimental and modelling approach to aortic valve viscoelasticity in tensile deformation
Anssari-Benam A, Bader DL, Screen HRC
J Mater Sci-Mater M vol. 22 (2), 253-262.  
01-02-2011
The effect of eccentric and concentric loading speed on the normal achilles tendon: an in vivo biomechanical study
Sweeney E, Chaudhury S, Screen H, Woledge R, Bader D, Maffulli N, Morrissey D
British Journal of Sports Medicine, Bmj vol. 45 (2) 
20-01-2011
The effect of loading speed on the force frequency spectrum during eccentric & concentric calf exercise
Chaudhry S, Screen HRC, Woledge RC, Bader D, Morrissey D
British Journal of Sports Medicine, Bmj vol. 45 (2) 
20-01-2011
Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH, Screen HRC
P I Mech Eng H vol. 225 (H8), 821-830.  
01-01-2011
Tendon material properties cannot be predicted by the material properties of the tendon fascicles
Thorpe CT, Udeze CP, Birch HL, Clegg PD, Screen HRC
 
01-01-2011
Fiber composite scaffolds uniquely regulate fibroblast response to cyclic tensile strain
Screen HRC, Demirci T, Lynn A, Blackney A, Patel D, Bryant SJ
 
01-01-2011

2010

Specimen dimensions influence the measurement of material properties in tendon fascicles
Legerlotz K, Riley GP, Screen HRC
Journal of Biomechanics vol. 43 (12), 2274-2280.  
01-08-2010
Characterization of a novel fiber composite material for mechanotransduction research of fibrous connective tissues
Screen HRC, Byers S, Lynn AD, Nguyen V, Patel D, Bryant SJ
Advanced Functional Materials vol. 20 (5), 738-747.  
09-03-2010
In situ multi-level analysis of viscoelastic deformation mechanisms in tendon collagen
Gupta HS, Seto J, Krauss S, Boesecke P, Screen HRC
Journal of Structural Biology vol. 169 (2), 183-191.  
01-02-2010
Dynamic Tracking of Tendon Elongation In Ultrasound Imaging
Karimpoor M, Screen H, Morrissey D
 
01-01-2010

2009

Measuring strain distributions in the tendon using confocal microscopy and finite elements
Screen HRC, Evans SL
J Strain Anal Eng vol. 44 (5), 327-335.  
01-07-2009
Hierarchical approaches to understanding tendon mechanics
SCREEN H
Journal of Biomechanical Science and Engineering, Japan Society of Mechanical Engineers vol. 4 (4), 481-499.  
01-01-2009

2008

Characterizing structure-function relationships in tendon
Toorani S, Shelton JC, Screen HRC
8th World Biomaterials Congress 2008 vol. 2 
01-12-2008
Investigating load relaxation mechanics in tendon
Screen HRC
Journal of The Mechanical Behavior of Biomedical Materials vol. 1 (1), 51-58.  
01-01-2008

2007

The micro-structural strain response of tendon
Cheng VWT, Screen HRC
J Mater Sci vol. 42 (21), 8957-8965.  
01-11-2007
The relationship between tendon composition, structure, and mechanical characteristics
Toorani S, Shelton JC, Screen HRC
 
01-07-2007
Strain mechanisms in tendon fascicles
SCREEN HRC, Cheng VWT
J.Mat.Sci. vol. 21, 8957-8965.  
01-01-2007

2006

The influence of swelling and matrix degradation on the microstructural integrity of tendon.
Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA, Shelton JC
Acta Biomater vol. 2 (5), 505-513.  
01-09-2006

2005

Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production
Screen HRC, Bader DL, Shelton JC, Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194.  
01-12-2005
Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.
Screen HRC, Shelton JC, Bader DL, Lee DA
Biochem Biophys Res Commun vol. 336 (2), 424-429.  
21-10-2005
The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.
Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL, Lee DA
Ann Biomed Eng vol. 33 (8), 1090-1099.  
01-08-2005
The effect of substrate and medium composition on the response of human dermal fibroblasts to cyclic tensile strain in vitro
Baria KE, Bader DL, Screen HRC, Lee DA
 
01-06-2005
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK

International Journal of Experimental Pathology, Wiley vol. 86 (3), a1-a56.  
24-05-2005

2004

Local Strain Measurement within Tendon
Bader DL, Shelton JC, Lee DA, SCREEN HRC
Strain vol. 40 (4), 157-163.  
01-11-2004
An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.
Screen HRC, Lee DA, Bader DL, Shelton JC
Proc Inst Mech Eng H vol. 218 (2), 109-119.  
01-01-2004

2003

Development of a technique to determine strains in tendons using the cell nuclei.
Screen HRC, Lee DA, Bader DL, Shelton JC
Biorheology vol. 40 (1-3), 361-368.  
01-01-2003
The effects on non-collagenous matrix components on tendon fascicle micromechanics.
SCREEN HRC, Shelton JC, Bader DL, Lee DA
49th Annual Meeting of the Orthopaedic Research Society. 
01-01-2003

2002

The strain behaviour of tendon under tensile load, using cell nuclei as strain markers.
SCREEN HRC, Lee DA, Bader DL, Shelton JC
48th Annual Meeting of the Orthopaedic Research Society. 
01-01-2002
Development of a technique to determine strains in tendons using the cell nuclei.
BADER DL, Shelton JC, Lee DA, Screen HRC
Biorheology vol. 40, 361-368.  
01-01-2002
Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain.
Bader DL, Shelton JC, Lee DA, SCREEN HRC
Eur. Cells Mat. vol. 4:S1, 41-42.  
01-01-2002
Non-collagenous matrix components influence the micro-mechanical environment of tenocytes within tendon fasciles subjected to tensile strain.
Bader DL, Shelton JC, LEE DA, Screen HRC
Eur. Cells Materials vol. 4 suppl 1, 41-42.  
01-01-2002

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet icon(Grant Transfer - Josephine Wu) Engineering functional tissues by spatiotemporal patterning: 3D bioprinting and optogenetics for directing the organization of cell spheroid building blocks (OPTO-BIOPRINTING)
Hazel Screen
£685,186 Wellcome Trust
15-08-2025 - 14-08-2030
solid heart iconHuman Tendon-CHIP: Novel In Vitro Predictive Models To Explore Tendinopathy
Hazel Screen, Xavier Griffin and John Connelly
£668,842 Medical Research Council
01-08-2025 - 31-07-2028
solid heart iconMicro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicines
Martin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council 
Grant Summary

01-10-2024 - 30-09-2027
solid heart iconEPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)
Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 Engineering and Physical Sciences Research Council 
Grant Summary

01-07-2024 - 30-09-2032
solid heart iconEpithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme 
Grant Summary

01-12-2023 - 30-11-2027
solid heart iconIncorporating physical cues in organ-chip models
Hazel Screen and Martin Knight
£20,000 Emulate Inc.
01-10-2022 - 30-09-2026
solid heart iconOrgan-on-a-chip Centre of Excellence
Martin Knight and Hazel Screen
£420,794 Emulate Inc.
20-08-2019 - 01-10-2029

solid heart iconOrgan-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacement
Hazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research 
Grant Summary

07-10-2024 - 14-03-2025
solid heart iconProduction of a Human Growth Plate Organ-Chip Model of Skeletal Development
Martin Knight, Clare Thompson and Hazel Screen
£197,923 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2023 - 31-07-2024
bullet iconConsultancy Hazel Screen, Frontier Space Technology Ltd Space Chips.
Hazel Screen
£9,000 Generic Commercial
01-01-2023 - 31-12-2023
bullet iconEmulate Organs-on-Chips Centre Technician
Martin Knight, Hazel Screen and Clare Thompson
£49,584 Emulate Inc.
01-01-2021 - 31-12-2023
solid heart iconMICA: Organ-on-a-chip models for safety testing of regenerative medicine products
Hazel Screen and Martin Knight
£473,325 MRC Medical Research Council
24-08-2020 - 24-05-2024
bullet iconDevelopment of a synovium-chondrocyte organ-on-a-chip model with integrated biomechanical
Hazel Screen and Clare Thompson
£9,068 EPSRC Engineering and Physical Sciences Research Council
01-07-2019 - 31-12-2019
bullet iconIdentifying the causes of age-related tendon injury
Hazel Screen
£213,898 DMT Dunhill Medical Trust, The
01-10-2018 - 30-12-2022
solid heart iconOrgan-on-a-chip technologies
Hazel Screen and Martin Knight
£479,339 Medical Research Council
01-08-2018 - 30-09-2022
bullet iconInvestigating Tendon mechanics and models of tendon pathology
Hazel Screen
£63,200 TRB CHEMEDICA Ltd
01-10-2017 - 30-09-2021
bullet iconTHaCH - The effects of hypercholesterolemia on tendon health (Tendon Health and CHolesterol)
Hazel Screen
£73,382 EU European Commission - Other
01-09-2016 - 05-11-2021
bullet iconEffective Injury Management & Prevention
Hazel Screen
£167,426 Horserace Betting Levy Board, T
01-07-2016 - 31-03-2019