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QM+Emulate Centre Research Projects

The Queen Mary+Emulate Organs-on-Chips Centre hosts an expanding range of research and development projects and has helped win over £3M of research funding since opening in 2019. The Centre is open for use by external academic institutions and industry and can help support research projects by providing access to Emulate facilities, support from our Centre Scientists and routes to commercialisation.

On this page:

Current Projects

Emulate organ chip

Advancing Human Synovial Joint Chips

Primary
Investigator:
Dr Karina Wright
Keele University
Co-investigators:Prof Sally Roberts
Keele University
 Dr Charlotte Hulme
Keele University
 Dr Clare Thompson
Queen Mary University of London
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Emulate Organ-chip

Development of a synovium-chondrocyte organ-on-a-chip model with integrated biomechanical stimulation

Primary
Investigator:
Prof Hazel Screen
Queen Mary University of London
Co-investigators:Dr Clare Thompson
Queen Mary University of London
 Prof Martin Knight
Queen Mary University of London
Funder:EPSRC OA Tech Network Plus - Pump Priming Grant
Staging of bladder cancer (https://www.macmillan.org.uk/)

Emulate-Bladder: A new dynamic in vitro human bladder model

Primary
Investigator:
Prof Mark Chambers
University of Surrey
Co-investigators:Prof Hardev Pandha
University of Surrey
 Prof Martin Knight
Queen Mary University of London
 Dr Guy Simpson
University of Surrey
 Dr Clare Thompson
Queen Mary University of London
Funder:The Organ-on-a-chip Technologies Network
Ciliated cells in Emulates lung chip

Establishing an 'old' and 'young' alveolar model to assess the impact of senescence on immunity to viruses

Primary
Investigator:
Dr Emma Chambers
Queen Mary University of London
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Emulate's Liver chip, MRP2 staining

Feasibility study to assess the use of organ-on-a-chip technology for optimization of radiotherapy cancer treatment.

Primary
Investigator:
Prof Giuseppe Schettino
University of Surrey
Co-investigators:Dr Eirini Velliou
University of Surrey
 Dr Priyanka Gupta
University of Surrey
 Dr Miriam Barry
National Physical Laboratory (NPL)
 Ms Chiara De Lucia
University of Surrey / NPL
Funder:The Organ-on-a-Chip Technologies Network
Human Kidney chip

Generation and validation of a urine-derived, personalised kidney-on-chip model for kidney disease and nephrotoxicity.

Primary
Investigator:
Prof John Sayer
Newcastle University
Co-investigator:Dr Elisa Molinari
Newcastle University
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Cells of the intestinal lining in Emulate's intestine chip, image credit Cedars-Sinai Board of Governors Regenerative Medicine Institute

Interrogating the role of hydrolases on colonic barrier dysfunction

Primary
Investigator:
Dr Rachael Barry
Imperial College London
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Schematic, ovarian cancer

Investigating the role of tumour associated myeloid cells on malignant cell invasion in a metastatic high-grade serous ovarian cancer-on-chip model

Primary
Investigator:
Prof Fran Balkwill
Queen Mary University of London
Co-investigator:Dr Mina Mincheva
Queen Mary University of London
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Mechanical regulation of synociocyte response

Mechanical regulation of synoviocyte response to pro-inflammatory cytokines and development of a synovium-cartilage chip

Primary
Investigator:
Prof Martin Knight
Queen Mary University of London
Co-investigators:Prof Hazel Screen
Queen Mary University of London
 Dr Clare Thompson
Queen Mary University of London
Funder:CONACyT PhD Studentship (2019-2023)
Tendon

Novel Models of Tendinopathy on a Chip

Primary
Investigator:
Prof Hazel Screen
Queen Mary University of London
Co-investigators:Prof Martin Knight
Queen Mary University of London
 Dr Clare Thompson
Queen Mary University of London
Funder:CONACyT PhD Studentship (2019-2023)
Cancer regulation of cilia

Organ-on-a-chip model to investigate breast cancer bone metastases

Primary
Investigator:
Prof Martin Knight
Queen Mary University of London
Co-investigator:Dr Oliver Pearce
Barts and The London School of Medicine and Dentistry
Funder:Cancer Research UK & EPSRC (Multidisciplinary Award)
Schematic of the Emulate Organ-chip

Organ-on-a-chip models for safety testing of regenerative medicine products

Primary
Investigator:
Prof Hazel Screen
Queen Mary University of London
Co-investigators:Prof Martin Knight
Queen Mary University of London
 Prof Alicia El Haj
University of Birmingham
Funder:MRC Medical Research Council
Emulate Covid19 Initiative

Understanding the mechanisms of vascular dysfunction in severe COVID-19

Primary
Investigator:
Prof Daniel Pennington
Barts and The London School of Medicine and Dentistry
Co-investigator:Dr Neil McKarthy
Barts and The London School of Medicine and Dentistry
Funder:Emulate Covid19 Initiative

Completed Projects

Emulates organ chip

Development of a human placental artery-on-a-chip to study placental vascular function in reproductive toxicology and pregnancy diseases

Primary
Investigator:
Dr Teresa TROPEA
University of Manchester
Co-investigators:Dr Paul Brownbill
University of Manchester
 Dr Virginia Pensebene
University of Leeds
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Ciliated cells inside Emulates Lung chip

Production and validation of a bovine lung-on-a-chip to study bovine respiratory diseases

Primary
Investigator:
Prof Mark Chambers
University of Surrey
Co-investigators:Dr Diane Lee
University of Surrey
 Prof Geoff Smith
North Carolina State University
 Prof Ronald Baynes
North Carolina State University
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Cultured SAEC in chip-s1

Precision reprogramming of immune cell metabolism to reduce inflammation and repolarise organ microenvironment using small molecules and metabolic intermediates.

Primary
Investigator:
Dr Kataryzna Swist-Szulik
Royal Manchester Children’s Hospital
Funder:Manchester Academic Health Science Centre (MAHSC)
Hepatocytes cultured in Emulate's Liver chip

Investigating the diagnostic and drug-screening potential of endothelial-to-mesenchymal transition during liver fibrosis.

Primary
Investigator:
Dr Neil Dufton
William Harvey Research Institute – QMUL
Co-investigator:Dr James Whiteford
William Harvey Research Institute – QMUL
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Emulate's intestine chip

Modelling anti-fungal immunity in the human intestine

Primary
Investigator:
Dr Neil McCarthy
Barts and The London School of Medicine and Dentistry
Co-investigators:Prof Carol Munro
University of Aberdeen
 Prof Daniel Pennington
Barts and The London School of Medicine and Dentistry
Funder:Emulate/Organ-on-a-chip Network Proof-of-concept Award
Primary cilia in bone cells

Development of an organ-on-a-chip model for bone

Primary
Investigator:
Prof Martin Knight
Queen Mary University of London
Co-investigators:Dr Cleo Bishop
Queen Mary University of London
 Dr Stefaan Verbruggen
Queen Mary University of London
Funder:BBSRC LIDo PhD Studentship (Rotation project)