Understanding the mechanisms of vascular dysfunction in severe COVID-19

Emulate Covid19 Initiative
Emulate Covid19 Initiative
Prof Daniel Pennington
Barts and The London School of Medicine and Dentistry
Co-investigator:Dr Neil McKarthy
Barts and The London School of Medicine and Dentistry
Funder:Emulate Covid19 Initiative
Project dates:01-01-2021 to 31-12-2021
Centre dates:01-01-2021 to 31-12-2021

Organs-on-Chips contain tiny hollow channels lined by living human cells that recreate the physical and mechanical environment experienced by cells within the human body.

The research team will use Emulate's new Lung-Chips models to compare the effects of plasma from severe Covid-19 patients and healthy controls on human lung cells. Professor Pennington, said: "As we continue to learn more about Covid-19, it's becoming clear that the virus doesn't only damage the lungs. Recent studies have shown that it may also affect blood vessels suggesting that there is an important vascular component to this disease."

"We hope to use this donation from Emulate, Inc to investigate how Covid-19 disrupts the interactions between endothelial cells that cover the surface of blood vessels and epithelial cells lining the lungs. Our findings could help to uncover new targets for potential therapeutic interventions against the disease."