Organ-on-a-Chip Network and Emulate Proof of Concept Awards
The UK Organ-on-a-Chip Network and Emulate, Inc. are pleased to offer Network members the opportunity to apply for a Proof of Concept Award to use a brand new core facility at Queen Mary University of London, The QM+Emulate Organs on Chips Centre.
This initiative aims to help academics win new research grants by providing organ-chips, access to the Emulate platform and support from the Centre Scientist. Researchers can apply to use Emulate’s platform technology, The Human Emulation system in a variety of different ways including:
- To generate preliminary data to support future grant applications
- To provide a direct contribution for a grant application
- To provide preliminary data leading to further use of the centre from existing funding
The total initiative, generously supported by Emulate, consists of approximately £100k of funding which is being used to support multiple research projects providing access to £120,000 of state-of-the-art organ-chip technology available at the The Queen Mary-Emulate Organs on Chips Centre.
Emulate’s platform has been adopted by 10 of the top 25 biopharmaceutical companies, by U.S. governmental agencies, and by academic research centres worldwide and provides an exciting opportunity for members of the UK organ-on-a-chip Network to engage with this technology.
Each project will be provided with:
- 8 Blank Emulate Organ-Chips
- Dedicated practical support from Centre Scientist
- Full access to the Organs-on-Chips Centre and associated equipment
Each project PI will be required to pay the Centre access fee of £600 which covers administration, training and some basic consumables for shorter projects. Please note, longer projects, and projects requiring remote working may require additional charging which will be discussed during the planning phase of the project.
Applicants will need to complete a project proposal form detailing the organ model they wish to use/develop, a brief outline of the experiment(s) they wish to conduct and information on how they intend to use the data generated to leverage further research funding. Centre staff are available to support application development and will work with successful applicants to plan their use of the facilities.
This initiative will operate a rolling call, application deadlines are as follows:
- 15th September 2020 (Closed)
- 1st March 2021 (Closed)
- Expected December 2021 (Next call deadline)
- April 2022
Eligibility: To apply for this proof-of-concept award applicants must be eligible for UKRI funding.
Completed project proposal forms to be returned to email@example.com by 16.00 on the day of each deadline, applications available below.
Proposals will be reviewed by a panel consisting of members of the network management group and the Emulate Centres joint steering committee.
Round 1 Awardees:
|Principal investigator:||Karina Wright, Keele University|
|Co-investigators:||Sally Roberts, Keele University
Charlotte Hulme, Keele University
|Principal investigator:||Rachael Barry, Imperial College London|
Investigating the diagnostic and drug-screening potential of endothelial-tomesenchymal transition during liver fibrosis
|Principal investigator:||Neil Dufton, Queen Mary University of London|
|Co-investigators:||James Whiteford, Queen Mary University of London|
|Principal investigator:||Neil McCarthy, Queen Mary University of London|
|Co-investigators:||Carol Munro, University of Aberdeen
Daniel Pennington, Queen Mary University of London
|Principal investigator:||Mark Chambers University of Surrey|
|Co-investigators:||Diane Lee, University of Surrey
Geoff Smith, North Carolina State University
Ronald Baynes, North Carolina State University
Round 2 Awardees:
Generation and validation of a urine-derived, personalised kidney-on-chip model for kidney disease and nephrotoxicity.
|Principal investigator:||Prof John Sayer, Newcastle University|
|Co-investigators:||Dr Elisa Molinari, Newcastle University|
Investigating the role of tumour associated myeloid cells on malignant cell invasion in a metastatic high-grade serous ovarian cancer-on-chip model
|Principal investigator:||Prof Fran Balkwill, Queen Mary University of London|
|Co-investigators:||Dr Mina Mincheva, Queen Mary University of London|
Establishing an 'old' and 'young' alveolar model to assess the impact of senescence on immunity to viruses
|Principal investigator:||Dr Emma Chambers, Queen Mary University of London|
Development of a human placental artery-on-a-chip to study placental vascular function in reproductive toxicology and pregnancy diseases
|Principal investigator:||Dr Teresa Tropea, University of Manchester|
Dr Paul Brownbill, University of Manchester
Dr Virginia Pensebene, University of Leeds