Organ-on-a-Chip Network and Emulate Proof of Concept Awards
The UK Organ-on-a-Chip Network and Emulate, Inc. are pleased to offer Network members the opportunity to apply for a Proof of Concept Award to use a brand new core facility at Queen Mary University of London, The QM+Emulate Organs on Chips Centre.
PoC Award Aim: The aim of the PoC award is to enable academics to generate preliminary data to support future grant applications and further use of the Emulate platform. This initiative will provide a limited number of blank organ-chips, hands-on training on the Emulate platform; and support to run a proof of concept experiment using the chips.
The total initiative, generously supported by Emulate, consists of approximately £100k of funding which is being used to support multiple research projects providing access to £120,000 of state-of-the-art organ-chip technology available at The Queen Mary+Emulate Organs-on-Chips Centre.
Emulate’s platform has been adopted by 10 of the top 25 biopharmaceutical companies, by U.S. governmental agencies, and by academic research centres worldwide and provides an exciting opportunity for members of the UK Organ-on-a-chip Network to engage with this technology.
Applications for Proof of Concept projects may develop new chip models or use Emulates current optimised organ models which include: Liver, Proximal Tubule Kidney, Brain, Lung, Colon Intestine and Duodenum Intestine.
Proposals will be reviewed by a panel consisting of members of the network management group and the Emulate Centre's joint steering committee. The will next meet on 21 January 2022.
Round 1 Awardees:
|Principal investigator:||Karina Wright, Keele University|
|Co-investigators:||Sally Roberts, Keele University
Charlotte Hulme, Keele University
|Principal investigator:||Rachael Barry, Imperial College London|
Investigating the diagnostic and drug-screening potential of endothelial-tomesenchymal transition during liver fibrosis
|Principal investigator:||Neil Dufton, Queen Mary University of London|
|Co-investigators:||James Whiteford, Queen Mary University of London|
|Principal investigator:||Neil McCarthy, Queen Mary University of London|
|Co-investigators:||Carol Munro, University of Aberdeen
Daniel Pennington, Queen Mary University of London
|Principal investigator:||Mark Chambers University of Surrey|
|Co-investigators:||Diane Lee, University of Surrey
Geoff Smith, North Carolina State University
Ronald Baynes, North Carolina State University
Round 2 Awardees:
Generation and validation of a urine-derived, personalised kidney-on-chip model for kidney disease and nephrotoxicity.
|Principal investigator:||Prof John Sayer, Newcastle University|
|Co-investigators:||Dr Elisa Molinari, Newcastle University|
Investigating the role of tumour associated myeloid cells on malignant cell invasion in a metastatic high-grade serous ovarian cancer-on-chip model
|Principal investigator:||Prof Fran Balkwill, Queen Mary University of London|
|Co-investigators:||Dr Mina Mincheva, Queen Mary University of London|
Establishing an 'old' and 'young' alveolar model to assess the impact of senescence on immunity to viruses
|Principal investigator:||Dr Emma Chambers, Queen Mary University of London|
Development of a human placental artery-on-a-chip to study placental vascular function in reproductive toxicology and pregnancy diseases
|Principal investigator:||Dr Teresa Tropea, University of Manchester|
Dr Paul Brownbill, University of Manchester
Dr Virginia Pensebene, University of Leeds