Project
Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease
Cells growing within the Emulate kidney chip -https://emulatebio.com/kidney-chip/
| Primary Investigator: | Prof Martin Knight Queen Mary University of London |
| Co-investigator: | Prof Cleo Bishop Queen Mary University of London |
| Funder: | EPSRC |
| Project dates: | 20-09-2021 to 31-03-2025 |
| Centre dates: | 20-09-2021 to 31-03-2025 |
This PhD studentship aims to develop an organ-chip model of Polycystic Kidney Disease and to use this to investigate the role of primary cilia mechanobiology and potential novel therapeutics. The project will test the hypothesis that pharmaceutical elongation of primary cilia in kidney epithelial cells enhances essential mechanotransduction. The student will examine whether this can compensate for the genetic disruption of cilia signalling that causes Polycystic Kidney Disease.