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Dr Matteo Palma

Matteo Palma

Reader in Nanoscience

Department of Chemistry, School of Physical and Chemical Science
Queen Mary Univeristy of London
ORCiD Google Scholar


Nanoscale bioengineering, DNA Nanotechnology, Biosensors, 1D and 2D Nanostructures, Nanopatterning

Underpinning Bioengineering


Nanoscale Bioengineering of systems , surfaces and devices . DNA nanotechnology, nano patterning nanomaterials, biosensing devices.


Publications of specific relevance to Predictive in vitro Models


Yue Y, Xu X, Zhang M, Yan Z, Koval V, Whiteley RM, Zhang D, Palma M, Abrahams I and Yan H (2021). Grain Size Effects in Mn-Modified 0.67BiFeO3-0.33BaTiO3Ceramics. Acs Applied Materials and Interfaces  vol. 13, (48) 57548-57559. 10.1021/acsami.1c16083
Fernandez-Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Thirumaran A, Stapleton A, Tofail SAM, Palma M, Kilcoyne M, Pandit A and Biggs MJ (2021). A Self-Powered Piezo-Bioelectric Device Regulates Tendon Repair-Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels. Advanced Materials  vol. 33, (40) 10.1002/adma.202008788
Xu X, Bowen BJ, Gwyther REA, Freeley M, Grigorenko B, Nemukhin AV, Eklöf-Österberg J, Moth-Poulsen K, Jones DD and Palma M (2021). Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices. Angewandte Chemie - International Edition  vol. 60, (37) 20184-20189. 10.1002/anie.202104044
Kousseff CJ, Taifakou FE, Neal WG, Palma M and Nielsen CB (2021). Controlling morphology, adhesion, and electrochromic behavior of PEDOT films through molecular design and processing. Journal of Polymer Science  10.1002/pol.20210522
Ye Q, Xu X, Paghi A, Bamford T, Horrocks BR, Houlton A, Barillaro G, Dimitrov S and Palma M (2021). Solution-Processable Carbon Nanotube Nanohybrids for Multiplexed Photoresponsive Devices. Advanced Functional Materials  10.1002/adfm.202105719
Degousée T, Untilova V, Vijaykumar V, Xu X, Sun Y, Palma M, Brinkmann M, Biniek L and Fenwick O (2021). High thermal conductivity states and enhanced figure of merit in aligned polymer thermoelectric materials. Journal of Materials Chemistry A  10.1039/d1ta03377h
Freeley M, Gwyther REA, Jones DD and Palma M (2021). DNA-Directed Assembly of Carbon Nanotube–Protein Hybrids. Mdpi Ag  Biomolecules  10.3390/biom11070955
Xu X, Mukadam Z, Amoroso G, Freeley M and Palma M (2021). Directed assembly of multiplexed single chirality carbon nanotube devices. Journal of Applied Physics  vol. 129, (2) 10.1063/5.0035820
Zhang M, Xu X, Yue Y, Palma M, Reece MJ and Yan H (2021). Multi elements substituted Aurivillius phase relaxor ferroelectrics using high entropy design concept. Elsevier  Materials and Design  109447-109447. 10.1016/j.matdes.2020.109447


Zhang H, Gidden H, Saunders TG, Liu N, Aurallo-Peters V, Xu X, Palma M, Reece MJ, Abrahams I, Yan H and Hao Y (2020). High Tunability and Low Loss in Layered Perovskite Dielectrics through Intrinsic Elimination of Oxygen Vacancies. American Chemical Society (Acs)  Chemistry of Materials  10.1021/acs.chemmater.0c03569
Finn P, Jacobs IE, Armitage J, Wu R, Paulsen B, Freeley M, Palma M, Rivnay J, Sirringhaus H and Nielsen C (2020). Effect of polar side chains on neutral and p-doped polythiophene. Journal of Materials Chemistry C  10.1039/d0tc04290k
Cervantes-Salguero K, Freeley M, Chávez JL and Palma M (2020). Single-molecule DNA origami aptasensors for real-time biomarker detection. Royal Society of Chemistry  Journal of Materials Chemistry B  vol. 8, (30) 6352-6356. 10.1039/d0tb01291b
Parr ZS, Rashid RB, Paulsen BD, Poggi B, Tan E, Freeley M, Palma M, Abrahams I, Rivnay J and Nielsen CB (2020). Semiconducting Small Molecules as Active Materials for p-Type Accumulation Mode Organic Electrochemical Transistors. Advanced Electronic Materials  10.1002/aelm.202000215
Zhang H, Giddens H, Yue Y, Xu X, Araullo-Peters V, Koval V, Palma M, Abrahams I, Yan H and Hao Y (2020). Polar nano-clusters in nominally paraelectric ceramics demonstrating high microwave tunability for wireless communication. Elsevier  Journal of The European Ceramic Society  10.1016/j.jeurceramsoc.2020.04.015
Amoroso G, Sapelkin A, Ye Q, Araullo-Peters V, Cecconello A, Fernandez G and Palma M (2020). DNA-Driven Dynamic Assembly of MoS2 Nanosheets. Royal Society of Chemistry  Faraday Discussions  10.1039/c9fd00118b


Bode DC, Freeley M, Nield J, Palma M and Viles JH (2019). Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy. J Biol Chem  vol. 294, (19) 7566-7572. 10.1074/jbc.AC118.007195
(2019). Direct synthesis of multiplexed metal nanowire based devices using carbon nanotubes as vector templates. Angew Chem Int Ed Engl  10.1002/anie.201902857
Clement P, Trinchera P, Cervantes-Salguero K, Ye Q, Jones CR and Palma M (2019). One‐step chemical strategy for the formation of carbon nanotube junctions in aqueous solution: The Reaction of DNA‐WrappedCarbon Nanotubes with Diazonium Salts. Wiley  Chempluschem  10.1002/cplu.201900151
Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M (2019). Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control. Royal Society of Chemistry (Rsc)  Faraday Discussions  10.1039/c9fd00023b
Amoroso G, Ye Q, Cervantes-Salguero K, Fernández G, Cecconello A and Palma M (2019). DNA-Powered Stimuli-Responsive Single-Walled Carbon Nanotube Junctions. Chemistry of Materials  vol. 31, (5) 1537-1542. 10.1021/acs.chemmater.8b04483
HUANG D, PATEL K, Perez-Garrido S, MARSHALL J and PALMA M (2019). DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single- Molecule Control. American Chemical Society  Acs Nano  10.1021/acsnano.8b08010


Freeley M, Attanzio A, Cecconello A, Amoroso G, Clement P, Fernandez G, Gesuele F and Palma M (2018). Tuning the Coupling in Single-Molecule Heterostructures: DNA-Programmed and Reconfigurable Carbon Nanotube-Based Nanohybrids. Adv Sci (Weinh)  vol. 5, (10) 1800596-1800596. 10.1002/advs.201800596
Attanzio A, Rosillo-Lopez M, Zampetti A, Ierides I, Cacialli F, Salzmann CG and Palma M (2018). Assembly of graphene nanoflake-quantum dot hybrids in aqueous solution and their performance in light-harvesting applications. Nanoscale  vol. 10, (42) 19678-19683. 10.1039/c8nr06746e
(2018). Attenuated Glial Reactivity on Topographically Functionalized Poly(3,4-Ethylenedioxythiophene):P-Toluene Sulfonate (PEDOT:PTS) Neuroelectrodes Fabricated by Microimprint Lithography. Small  vol. 14, (28) e1800863-e1800863. 10.1002/smll.201800863
Huang D, Freeley M and Palma M (2018). Single-Molecule Patterning via DNA Nanostructure Assembly: A Reusable Platform. Methods Mol Biol  vol. 1811, 231-251. 10.1007/978-1-4939-8582-1_16
Xu X, Clément P, Eklöf-Österberg J, Kelley-Loughnane N, Moth-Poulsen K, Chávez JL and Palma M (2018). Reconfigurable Carbon Nanotube Multiplexed Sensing Devices. American Chemical Society  Nano Letters  vol. 18, (7) 4130-4135. 10.1021/acs.nanolett.8b00856


Freeley M, Worthy HL, Ahmed R, Bowen B, Watkins D, Macdonald JE, Zheng M, Jones DD and Palma M (2017). Site-Specific One-to-One Click Coupling of Single Proteins to Individual Carbon Nanotubes: A Single-Molecule Approach. J Am Chem Soc  vol. 139, (49) 17834-17840. 10.1021/jacs.7b07362
Taroni PJ, SANTAGIULIANA G, WAN K, Calado P, QIU M, ZHANG H, PUGNO N, PALMA M, Stingelin-Stutzmann N, Heeney M, FENWICK O, BAXENDALE M and BILOTTI E (2017). Toward Stretchable Self-Powered Sensors Based on the Thermoelectric Response of PEDOT:PSS/Polyurethane Blends. Wiley  Advanced Functional Materials  10.1002/adfm.201704285
Biggs MJP, Fernandez M, Thomas D, Cooper R, Palma M, Liao J, Fazio T, Dahlberg C, Wheadon H, Pallipurath A, Pandit A, Kysar J and Wind SJ (2017). The Functional Response of Mesenchymal Stem Cells to Electron-Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity. Advanced Materials  vol. 29, (39) 10.1002/adma.201702119
McMorrow J, Freeley M and Palma M (2017). DNA-Wrapped Single-Walled Carbon Nanotube Assemblies. Industrial and Engineering Chemistry Research  vol. 56, (18) 5302-5308. 10.1021/acs.iecr.7b00429
Huang D, Freeley M and PALMA M (2017). DNA-Mediated Patterning of Single-Quantum Dot Nanoarrays: A Reusable Platform for Single-Molecule Control. Nature Publishing Group  Scientific Reports  10.1038/srep45591
Attanzio A, Sapelkin A, Gesuele F, van der Zande A, Gillin W, Zheng M and Palma M (2017). Carbon Nanotube-Quantum Dot Nanohybrids: Coupling with Single Particle Control in Aqueous Solution. Wiley - V C H Verlag Gmbbh & Co.  Small  10.1002/smll.201603042


Wang J, Campos I, Wu F, Zhu J, Sukhorukov GB, Palma M, Watkinson M and Krause S (2016). The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy. Electrochimica Acta  vol. 208, 39-46. 10.1016/j.electacta.2016.05.017
Hardy JG, Palma M, Wind SJ and Biggs MJ (2016). Responsive Biomaterials: Advances in Materials Based on Shape-Memory Polymers. Adv Mater  vol. 28, (27) 5717-5724. 10.1002/adma.201505417
Zhu J, McMorrow J, Crespo-Otero R, Ao G, Zheng M, Gillin WP and Palma M (2016). Solution-Processable Carbon Nanoelectrodes for Single-Molecule Investigations. J Am Chem Soc  vol. 138, (9) 2905-2908. 10.1021/jacs.5b12086
Penzo E, Palma M, Chenet DA, Ao G, Zheng M, Hone JC and Wind SJ (2016). Directed Assembly of Single Wall Carbon Nanotube Field Effect Transistors. Acs Nano  vol. 10, (2) 2975-2981. 10.1021/acsnano.6b00353


PALMA M, Hardy JG, Tadayyon G, Farsan M and Wind SJ (2015). Advances in Functional Assemblies for Regenerative Medicine. Wiley Online  Advanced Healthcare Materials  vol. 4, (16) 2500-2519. 10.1002/adhm.201500412
Penzo E, Palma M, Wang R, Cai H, Zheng M and Wind SJ (2015). Directed Assembly of End-Functionalized Single Wall Carbon Nanotube Segments. Nano Letters  vol. 15, (10) 6547-6552. 10.1021/acs.nanolett.5b02220


Cai H, Depoil D, Palma M, Sheetz MP, Dustin ML and Wind SJ (2013). Bifunctional nanoarrays for probing the immune response at the single-molecule level. J Vac Sci Technol B Nanotechnol Microelectron  vol. 31, (6) 10.1116/1.4823764
Kinz-Thompson CD, Palma M, Pulukkunat DK, Chenet D, Hone J, Wind SJ and Gonzalez RL (2013). Robustly passivated, gold nanoaperture arrays for single-molecule fluorescence microscopy. Acs Nano  vol. 7, (9) 8158-8166. 10.1021/nn403447s
Palma M, Wang W, Penzo E, Brathwaite J, Zheng M, Hone J, Nuckolls C and Wind SJ (2013). Controlled formation of carbon nanotube junctions via linker-induced assembly in aqueous solution. J Am Chem Soc  vol. 135, (23) 8440-8443. 10.1021/ja4018072
Wang R, Palma M, Penzo E and Wind SJ (2013). Lithographically directed assembly of one-dimensional DNA nanostructures via bivalent binding interactions. Nano Research  vol. 6, (6) 409-417. 10.1007/s12274-013-0318-6


Abramson J, Palma M, Wind SJ and Hone J (2012). Quantum dot nanoarrays: self-assembly with single-particle control and resolution. Adv Mater  vol. 24, (16) 2207-2211. 10.1002/adma.201104216
Schiros T, Mannsfeld S, Chiu C-Y, Yager KG, Ciston J, Gorodetsky AA, Palma M, Bullard Z, Kramer T, Delongchamp D, Fischer D, Kymissis I, Toney MF and Nuckolls C (2012). Reticulated Organic Photovoltaics. Advanced Functional Materials  vol. 22, (6) 1167-1173. 10.1002/adfm.201102572


Penzo E, Wang R, Palma M and Wind SJ (2011). Selective placement of DNA origami on substrates patterned by nanoimprint lithography. Journal of Vacuum Science & Technology B  vol. 29, (6) 10.1116/1.3646900
Palma M, Abramson JJ, Gorodetsky AA, Penzo E, Gonzalez RL, Sheetz MP, Nuckolls C, Hone J and Wind SJ (2011). Selective biomolecular nanoarrays for parallel single-molecule investigations. J Am Chem Soc  vol. 133, (20) 7656-7659. 10.1021/ja201031g
Schvartzman M, Palma M, Sable J, Abramson J, Hu X, Sheetz MP and Wind SJ (2011). Nanolithographic control of the spatial organization of cellular adhesion receptors at the single-molecule level. Nano Lett  vol. 11, (3) 1306-1312. 10.1021/nl104378f
Palma M, Abramson JJ, Gorodetsky AA, Nuckolls C, Sheetz MP, Wind SJ and Hone J (2011). Controlled confinement of DNA at the nanoscale: nanofabrication and surface bio-functionalization. Methods Mol Biol  vol. 749, 169-185. 10.1007/978-1-61779-142-0_12
Savage RC, Mativetsky JM, Orgiu E, Palma M, Gbabode G, Geerts YH and Samori P (2011). Integration of self-assembled discotic-based fibres into field-effect transistors: a comparison of preparation approaches. Journal of Materials Chemistry  vol. 21, (1) 206-213. 10.1039/c0jm01754j


Gorodetsky AA, Chiu C-Y, Schiros T, Palma M, Cox M, Jia Z, Sattler W, Kymissis I, Steigerwald M and Nuckolls C (2010). Reticulated heterojunctions for photovoltaic devices. Angew Chem Int Ed Engl  vol. 49, (43) 7909-7912. 10.1002/anie.201004055


Mativetsky JM, Kastler M, Savage RC, Gentilini D, Palma M, Pisula W, Muellen K and Samori P (2009). Self-Assembly of a Donor-Acceptor Dyad Across Multiple Length Scales: Functional Architectures for Organic Electronics. Advanced Functional Materials  vol. 19, (15) 2486-2494. 10.1002/adfm.200900366
Schvartzman M, Nguyen K, Palma M, Abramson J, Sable J, Hone J, Sheetz MP and Wind SJ (2009). Fabrication of Nanoscale Bioarrays for the Study of Cytoskeletal Protein Binding Interactions Using Nanoimprint Lithography. J Vac Sci Technol B Microelectron Nanometer Struct Process Meas Phenom  vol. 27, (1) 61-65. 10.1116/1.3043472


Mativetsky JM, Palma M and Samorì P (2008). Exploring electronic transport in molecular junctions by conducting atomic force microscopy. Top Curr Chem  vol. 285, 157-202. 10.1007/128_2007_25
Palma M, Levin J, Debever O, Geerts Y, Lehmann M and Samori P (2008). Self-assembly of hydrogen-bond assisted supramolecular azatriphenylene architectures. Soft Matter  vol. 4, (2) 303-310. 10.1039/b713570j


Palermo V, Liscio A, Palma M, Surin M, Lazzaroni R and Samori P (2007). Exploring nanoscale electrical and electronic properties of organic and polymeric functional materials by atomic force microscopy based approaches. Chemical Communications  (32) 3326-3337. 10.1039/b701015j


Palma M, Levin J, Lemaur V, Liscio A, Palermo V, Cornil J, Geerts Y, Lehmann M and Samori P (2006). Self-organization and nanoscale electronic properties of azatriphenylene-based architectures: A scanning probe microscopy study. Advanced Materials  vol. 18, (24) 3313-+. 10.1002/adma.200601437
Palermo V, Palma M and Samorì P (2006). Electronic Characterization of Organic Thin Films by Kelvin Probe Force Microscopy. Scanning Probe Microscopies Beyond Imaging: Manipulation of Molecules and Nanostructures  10.1002/3527608516.ch13
Palermo V, Morelli S, Palma M, Simpson C, Nolde F, Herrmann A, Mullen K and Samori P (2006). Nanoscale structural and electronic properties of ultrathin blends of two polyaromatic molecules: A Kelvin Probe Force Microscopy investigation. Chemphyschem  vol. 7, (4) 847-853. 10.1002/cphc.200500480
Palermo V, Palma M and Samori P (2006). Electronic characterization of organic thin films by Kelvin probe force microscopy. Advanced Materials  vol. 18, (2) 145-164. 10.1002/adma.200501394
Palma M, Pace G, Roussel O, Geerts Y and Samori P (2006). STM investigation of alkylated thiotriphenylene monolayers at the solid-liquid interface: Structure and dynamics. Australian Journal of Chemistry  vol. 59, (6) 376-380. 10.1071/CH06142


Palermo V, Palma M, Tomovic Z, Watson MD, Friedlein R, Mullen K and Samori P (2005). Influence of molecular order on the local work function of nanographene architectures: A Kelvin-probe force microscopy study. Chemphyschem  vol. 6, (11) 2371-2375. 10.1002/cphc.200500181


Grants of specific relevance to Predictive in vitro Models
DNA Nanotechnology for Single-Molecule Monitoring of Target-Analyte Interactions
Palma M
USD294,700 Air Force Office of Scientific Research Grant (01-06-2017 - 01-06-2020)
Single-Molecule Bioelectronic Devices with Multi-Sensing Capability
Palma M
USD224,900 Air Force Office of Scientific Research (28-09-2016 - 01-09-2019)

Fundamental membrane interactions of copper generated oligomers, profibrils and amyloid fibres
Viles JH, Baker MD, Milanesi L, Palma M and Nield J
£346,238 Biotechnology and Biological Sciences Research Council (31-07-2015 - 30-07-2019)
Towards Solution Processable Single- Molecule Devices: Controlled Assembly of Carbon Nanotube Electrodes for Molecular Electronics
Palma M
£125,000 Engineering and Physical Sciences Research Council (01-10-2015 - 30-09-2017)