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Prof Andrew Tinker

Andrew Tinker

William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London

www.qmul.ac.uk/whri/people/academic-staff/items/tinkerandrew.html

Research

Interests

An interest in iPSC models for cardiac disease modelling

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A and Morris AP (2020). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications  vol. 11, (1) 10.1038/s41467-020-15706-x
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Springer Science and Business Media Llc  Journal of Molecular Medicine  10.1007/s00109-020-01946-3
Villar D, Frost S, Deloukas P and Tinker A (2020). The contribution of non-coding regulatory elements to cardiovascular disease. Open Biology  vol. 10, (7) 10.1098/rsob.200088
van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB and Lambiase PD (2020). Genetic Basis and Prognostic Value of Exercise QT Dynamics. Circ Genom Precis Med  10.1161/CIRCGEN.119.002774
Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV, Stewart M, Tinker A, Cox RD and Metherell LA (2020). Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not. Life Science Alliance  vol. 3, (4) 10.26508/lsa.201900593
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB and Tinker A (2020). Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. American Journal of Human Genetics  10.1016/j.ajhg.2020.04.009

2019

Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M and Munroe PB (2019). Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics. American Heart Association  Circulation: Arrhythmia and Electrophysiology  vol. 12, (10) e007549-e007549. 10.1161/CIRCEP.119.007549
Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A and Munroe PB (2019). Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function. Hum Mol Genet  10.1093/hmg/ddz198
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA, Barnes MR, Munroe PB and Tinker A (2019). Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages. Physiol Genomics  vol. 51, (8) 323-332. 10.1152/physiolgenomics.00012.2019
Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA, Huang CL-H, Lambiase PD and Tinker A (2019). Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome. Am J Physiol Cell Physiol  10.1152/ajpcell.00028.2019
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen LP, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA, Shah N, Schramm K, Vidigal PG, Weiss S and Yao J (2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. Journal of The American College of Cardiology  vol. 73, (24) 3118-3131. 10.1016/j.jacc.2019.03.519
(2019). Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype. British Journal of Dermatology  vol. 180, (5) 1114-1122. 10.1111/bjd.17388
Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A and Schilling RJ (2019). Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method. J Cardiovasc Electrophysiol  vol. 30, (5) 691-701. 10.1111/jce.13882
Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A, Rodriguez B and Harmer SC (2019). Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D. Front Physiol  vol. 10, 259-259. 10.3389/fphys.2019.00259

2018

Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng KE, Blaydon DC, Tinker A, Kelsell DP and Chikh A (2018). P63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Nature Communications  vol. 9, (1) 10.1038/s41467-018-03470-y
Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A, Lambiase PD and Munroe PB (2018). Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system. Nature Communications  vol. 9, (1) 10.1038/s41467-018-04148-1
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A and Denning C (2018). CRISPR/Cas9 editing in human pluripotent stemcell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. European Heart Journal  vol. 39, (43) 3879-3892. 10.1093/eurheartj/ehy249
Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M, Taggart P, Lambiase PD, Gourine A, Tinker A and Gourine AV (2018). Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1). Circ Arrhythm Electrophysiol  vol. 11, (10) e006740-e006740. 10.1161/CIRCEP.118.006740
Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A and Scambler PJ (2018). Defective Vagal Innervation in Murine Tbx1 Mutant Hearts. J Cardiovasc Dev Dis  vol. 5, (4) 10.3390/jcdd5040049
Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA, Huang CL-H, Ben Simon R, Tinker A and Lambiase PD (2018). Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome. Circ Arrhythm Electrophysiol  vol. 11, (9) e006330-e006330. 10.1161/CIRCEP.118.006330
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F and Ramirez J (2018). Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biology  vol. 19, (1) 10.1186/s13059-018-1457-6
Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A and Tinker A (2018). ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. Journal of Biological Chemistry  vol. 293, (23) 8912-8921. 10.1074/jbc.RA118.002775
Nobles M, Montaigne D, Sebastian S, Birnbaumer L and Tinker A (2018). Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria. Am J Physiol Cell Physiol  vol. 314, (5) C616-C626. 10.1152/ajpcell.00271.2016
Tinker A, Finlay M, Nobles M and Opel A (2018). Erratum to The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation [Pharmacol. Res. 105 (2016) 54-61]. Pharmacol Res  vol. 129, 10.1016/j.phrs.2018.02.019
Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE, Osumi-Sutherland D, Campbell NH, Huntley RP, Talmud PJ, Blake JA, Breckenridge R, Riley PR, Lambiase PD, Elliott PM, Clapp L, Tinker A and Hill DP (2018). Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology. Circ Genom Precis Med  vol. 11, (2) e001813-e001813. 10.1161/CIRCGEN.117.001813
Tinker A, Aziz Q, Li Y and Specterman M (2018). ATP-sensitive potassium channels and their physiological and pathophysiological roles. Comprehensive Physiology  vol. 8, (4) 1463-1511. 10.1002/cphy.c170048
Aziz Q, Li Y and Tinker A (2018). Potassium channels in the sinoatrial node and their role in heart rate control. Channels  vol. 12, (1) 356-366. 10.1080/19336950.2018.1532255
Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C, Tinker A, Harmer SC, Aziz Q, Terry A, Struebig M, Warren HR, Vadgama B, Fowler DJ, Peebles D, Taylor AM, Lally PJ and Thayyil S (2018). Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Circulation. Genomic and Precision Medicine  vol. 11, (1) 10.1161/CIRCGEN.117.001817
Orini M, Tinker A, Munroe PB and Lambiase PD (2018). Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Plos One  vol. 13, (2) e0193039-e0193039. 10.1371/journal.pone.0193039

2017

Aziz Q, Li Y and Tinker A (2017). Endothelial biology and ATP-sensitive potassium channels. Channels  1-2. 10.1080/19336950.2017.1412151
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD and Tinker A (2017). Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Research  vol. 25, 233-244. 10.1016/j.scr.2017.11.003
TINKER A and Lane J D (2017). Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology? Frontiers Media  Frontiers in Physiology  vol. 8, 10.3389/fphys.2017.00890
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG and Tarasova YS (2017). Mammalian γ2 AMPK regulates intrinsic heart rate. Macmillan Publications  Nat Commun  vol. 8, (1) 1258-1258. 10.1038/s41467-017-01342-5
Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E and Tinker A (2017). Molecular and functional characterization of the endothelial ATP-sensitive potassium channel. Journal of Biological Chemistry  vol. 292, (43) 17587-17597. 10.1074/jbc.M117.810325
Royal AA, Tinker A and Harmer SC (2017). Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking. Public Library of Science  Plos One  vol. 12, (10) e0186293-e0186293. 10.1371/journal.pone.0186293
Lane JD, Montaigne D and Tinker A (2017). Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. J Membr Biol  vol. 250, (5) 471-481. 10.1007/s00232-017-9973-y
Orini M, Tinker A, Munroe PB and Lambiase PD (2017). Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Public Library of Science  Plos One  vol. 12, (9) e0183732-e0183732. 10.1371/journal.pone.0183732
Tinker A (2017). The mechanisms of ventricular arrhythmia in Chagas disease. Int J Cardiol  vol. 240, 372-373. 10.1016/j.ijcard.2017.03.094
Munroe PB and Tinker A (2017). Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart  vol. 104, (1) 6-7. 10.1136/heartjnl-2017-311657
Finlay M, Harmer SC and Tinker A (2017). The control of cardiac ventricular excitability by autonomic pathways. Pharmacology and Therapeutics  vol. 174, 97-111. 10.1016/j.pharmthera.2017.02.023
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T, Guasti L and Dunkel L (2017). Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Molecular and Cellular Endocrinology  vol. 447, 12-22. 10.1016/j.mce.2017.02.030
MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H and Cabrera CP (2017). Discovery of novel heart rate-associated loci using the exome chip. Oxford University Press (Oup)  Human Molecular Genetics  10.1093/hmg/ddx113

2016

MUNROE PB (2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Publishing Group  Nature Genetics  10.1038/ng.3654
Ang R, Abramowitz J, Birnbaumer L, Gourine AV and Tinker A (2016). The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. Physiol Rep  vol. 4, (15) 10.14814/phy2.12860
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K (2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep  vol. 16, (4) 1026-1038. 10.1016/j.celrep.2016.06.050
Tinker A, Finlay M, Nobles M and Opel A (2016). The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation. Pharmacol Res  vol. 105, 54-61. 10.1016/j.phrs.2015.11.008
Harmer SC and Tinker A (2016). The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes. De Gruyter  Biol Chem  vol. 397, (7) 679-693. 10.1515/hsz-2015-0306
Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin JP and Varro A (2016). Human-based approaches to pharmacology and cardiology: An interdisciplinary and intersectorial workshop. Europace  vol. 18, (9) 1287-1298. 10.1093/europace/euv320
Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A and Baker JR (2016). Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines. Organic and Biomolecular Chemistry  vol. 14, (2) 455-459. 10.1039/c5ob02120k

2015

Munroe PB and Tinker A (2015). Genome-wide association studies and contribution to cardiovascular physiology. Physiological Genomics  vol. 47, (9) 365-375. 10.1152/physiolgenomics.00004.2015
Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A and Baker JR (2015). A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging. Organic and Biomolecular Chemistry  vol. 13, (37) 9559-9563. 10.1039/c5ob01468a
Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R and Tinker A (2015). Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling. J Biol Chem  vol. 290, (31) 19233-19244. 10.1074/jbc.M115.666719
Lambiase PD and Tinker A (2015). Connexins in the heart. Cell Tissue Res  vol. 360, (3) 675-684. 10.1007/s00441-014-2020-8
Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A and Hussain K (2015). Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8. Human Molecular Genetics  vol. 24, (18) 5142-5153. 10.1093/hmg/ddv233
Notari M, Hu Y, Sutendra G, Dedei Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJP, Kelsell DP, De Noronha S, Sheppard MN, Hollinshead M, Mohun TJ and Lu X (2015). iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proceedings of The National Academy of Sciences of The United States of America  vol. 112, (9) E973-E981. 10.1073/pnas.1408111112
Aziz Q, Li Y and Tinker A (2015). ATP-sensitive potassium channels and vascular function. Channels  vol. 9, (1) 3-4. 10.1080/19336950.2015.1004289
Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A, Marina N and Gourine AV (2015). Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Heart Rhythm  vol. 12, (11) 2285-2293. 10.1016/j.hrthm.2015.06.005

2014

Lane JD, Abramowitz J, Birnbaumer L and Tinker A (2014). 51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure. Europace  vol. 16 Suppl 3, 10.1093/europace/euu241.1
Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L and Tinker A (2014). The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control. Hypertension  vol. 64, (3) 523-529. 10.1161/HYPERTENSIONAHA.114.03116
Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD and Tinker A (2014). Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1. Biochem J  vol. 462, (1) 133-142. 10.1042/BJ20140425
Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A and Baker JR (2014). Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. Organic & Biomolecular Chemistry  vol. 12, (4) 557-560. 10.1039/c3ob42141d
Tinker A, Aziz Q and Thomas A (2014). The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system. Br J Pharmacol  vol. 171, (1) 12-23. 10.1111/bph.12407
Arya VB, Aziz Q, Nessa A, Tinker A and Hussain K (2014). Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy. Int J Pediatr Endocrinol  vol. 2014, (1) 10.1186/1687-9856-2014-24

2013

Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K and Martemyanov KA (2013). Essential Role of the m(2)R-RGS6-I-KACh Pathway in Controlling Intrinsic Heart Rate Variability. Plos One  vol. 8, (10) 10.1371/journal.pone.0076973
Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L and Tinker A (2013). The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins. Am J Physiol Regul Integr Comp Physiol  vol. 305, (4) R435-R442. 10.1152/ajpregu.00037.2013
Telezhkin V, Thomas AM, Harmer SC, Tinker A and Brown DA (2013). A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P-2. Pflugers Archiv-European Journal of Physiology  vol. 465, (7) 945-953. 10.1007/s00424-012-1199-3
Schwarzer S, Mashanov GI, Molloy JE and Tinker A (2013). Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly. Methods Mol Biol  vol. 998, 201-208. 10.1007/978-1-62703-351-0_15

2012

Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A and Ruhrberg C (2012). NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Developmental Biology  vol. 369, (2) 277-285. 10.1016/j.ydbio.2012.06.026
Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H, Davidson S, Zuberi Z, Tinker A, Shui B, Tallini YI, Kotlikoff MI, Miquerol L, Schwartz RJ and Riley PR (2012). Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Circ Res  vol. 111, (2) e19-e31. 10.1161/CIRCRESAHA.111.260695
Harmer SC, Mohal JS, Kemp D and Tinker A (2012). Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel. Biochem J  vol. 443, (3) 635-642. 10.1042/BJ20111912
Telezhkin V, Reilly JM, Thomas AM, Tinker A and Brown DA (2012). Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding. Journal of Biological Chemistry  vol. 287, (13) 10001-10012. 10.1074/jbc.M111.322552
Aziz Q, Thomas AM, Khambra T and Tinker A (2012). Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C. J Biol Chem  vol. 287, (9) 6196-6207. 10.1074/jbc.M111.243923
Ang R, Opel A and Tinker A (2012). The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias. Front Physiol  vol. 3, 10.3389/fphys.2012.00096
Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, TINKER A and Lambiase PD (2012). Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Oxford University Press  Eur Heart Journal  vol. 33, (15) 1942-1953. 10.1093/eurheartj/ehr472

2011

Thomas AM, Harmer SC, Khambra T and Tinker A (2011). Characterization of a binding site for anionic phospholipids on KCNQ1. Journal of Biological Chemistry  vol. 286, 2088-2100. 10.1074/jbc.M110.153551

2010

Mashanov GI, Nobles M, Harmer SC, Molloy JE and Tinker A (2010). Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior. Journal of Biological Chemistry  vol. 285, 3664-3675. 10.1074/jbc.M109.039974

2008

Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AR, TINKER A and Duchen MR (2008). Regulation of mitochondrial structure and function by IF1, the endogenous inhibitor of the mitochondrial ATPase. Cell Metabolism  vol. 8, (1) 13-25. 10.1016/j.cmet.2008.06.001

Grants

Grants of specific relevance to Predictive in vitro Models
The genetic architecture of heart rate and the electrocardiogram at rest and during exercise
Munroe PB, Lambiase PD, Tinker A and Orini M
£600,142 Medical Research Council (03-01-2017 - 01-05-2020)
Abstract
Characterisation of the physiological roles and pathological significance of endothelium-derived C-type natriuretic peptide: a novel vasoprotective signalling paradigm.
Hobbs AJ, Ahluwalia A and Tinker A
£476,952 Wellcome Trust (04-11-2008 - 03-07-2011)
Abstract