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Prof Andrew Tinker

Andrew Tinker
William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London

www.qmul.ac.uk/whri/people/academic-staff/items/tinkerandrew.html

Research

Interests

An interest in iPSC models for cardiac disease modelling

Publications

Publications of specific relevance to Predictive in vitro Models

2021

Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB and Tinker A (2021). The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate. Physiological Genomics  vol. 53, (4) 150-159. 10.1152/physiolgenomics.00157.2020
Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD, Tinker A, Marouli E, Munroe PB and Ramírez J (2021). No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis. Frontiers in Genetics  vol. 12, 10.3389/fgene.2021.569323
Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A and Munroe PB (2021). Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function. Human Molecular Genetics  vol. 29, (5) 1797-1807. 10.1093/HMG/DDZ198

2020

Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A and Morris AP (2020). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications  vol. 11, (1) 10.1038/s41467-020-15706-x
Ramírez J and Tinker A (2020). Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses. Function  vol. 2, (1) 10.1093/function/zqaa038
Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD and Orini M (2020). A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs. Elsevier  Biomedical Signal Processing and Control  vol. 64, 10.1016/j.bspc.2020.102305
Balestrini S, Mikati MA, Garcia-Roves RA, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L, De Grandis E, Gagliardi A, Pisciotta L, Stagnaro M, Veneselli E, Campistol J, Fons C, Pias-Peleteiro L, Brashear A, Miller C, Samoes R, Brankovic V, Padiath QS, Potic A, Pilch J, Vezyroglou K, Bye AME, Davis AM, Ryan MM, Semsarian C, Hollingsworth G and Scheffer IE (2020). Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study. American Academy of Neurology  Neurology  10.1212/WNL.0000000000010794
Li Y, Aziz Q, Anderson N, Ojake L and Tinker A (2020). Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis. American Heart Association  Hypertension  HYPERTENSIO-HYPERTENSIO. 10.1161/HYPERTENSIONAHA.120.15355
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Springer Science and Business Media Llc  Journal of Molecular Medicine  10.1007/s00109-020-01946-3
Villar D, Frost S, Deloukas P and Tinker A (2020). The contribution of non-coding regulatory elements to cardiovascular disease. The Royal Society  Open Biology  vol. 10, (7) 200088-200088. 10.1098/rsob.200088
Aziz Q and Tinker A (2020). The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. Oup  Function  vol. 1, (1) zqaa005-zqaa005. 10.1093/function/zqaa005
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB and Tinker A (2020). Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. American Journal of Human Genetics  vol. 106, (6) 764-778. 10.1016/j.ajhg.2020.04.009
Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV, Stewart M, Tinker A, Cox RD and Metherell LA (2020). Mylk3 null c57bl/6n mice develop cardiomyopathy, whereas nnt null c57bl/6j mice do not. Life Science Alliance  vol. 3, (4) 10.26508/LSA.201900593
Aziz Q, Nobles M and Tinker A (2020). Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells. Bio Protoc  vol. 10, (1) 10.21769/BioProtoc.3478
Aziz Q, Nobles M and Tinker A (2020). Acute Isolation of Cells from Murine Sino-atrial Node. Bio Protoc  vol. 10, (1) 10.21769/BioProtoc.3477
Van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB and Lambiase PD (2020). Genetic Basis and Prognostic Value of Exercise QT Dynamics. Circulation: Genomic and Precision Medicine  231-239. 10.1161/CIRCGEN.119.002774

2019

Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M and Munroe PB (2019). Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics. American Heart Association  Circulation: Arrhythmia and Electrophysiology  vol. 12, (10) e007549-e007549. 10.1161/CIRCEP.119.007549
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA, Barnes MR, Munroe PB and Tinker A (2019). Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages. Physiol Genomics  vol. 51, (8) 323-332. 10.1152/physiolgenomics.00012.2019
Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA, Huang CL-H, Lambiase PD and Tinker A (2019). Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome. Am J Physiol Cell Physiol  10.1152/ajpcell.00028.2019
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen LP, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA, Shah N, Schramm K, Vidigal PG, Weiss S and Yao J (2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. Journal of The American College of Cardiology  vol. 73, (24) 3118-3131. 10.1016/j.jacc.2019.03.519
(2019). Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype. British Journal of Dermatology  vol. 180, (5) 1114-1122. 10.1111/bjd.17388
Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A and Schilling RJ (2019). Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method. Journal of Cardiovascular Electrophysiology  vol. 30, (5) 691-701. 10.1111/jce.13882
(2019). DSP 突变与致心律失常性心肌病. British Journal of Dermatology  vol. 180, (5) e169-e169. 10.1111/bjd.17808
(2019). DSP mutations and arrhythmogenic cardiomyopathy. British Journal of Dermatology  vol. 180, (5) e157-e157. 10.1111/bjd.17796
Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A, Rodriguez B and Harmer SC (2019). Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D. Front Physiol  vol. 10, 259-259. 10.3389/fphys.2019.00259

2018

Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng KE, Blaydon DC, Tinker A, Kelsell DP and Chikh A (2018). P63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Nature Communications  vol. 9, (1) 10.1038/s41467-018-03470-y
Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A, Lambiase PD and Munroe PB (2018). Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system. Nature Communications  vol. 9, (1) 10.1038/s41467-018-04148-1
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A and Denning C (2018). CRISPR/Cas9 editing in human pluripotent stemcell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. European Heart Journal  vol. 39, (43) 3879-3892. 10.1093/eurheartj/ehy249
Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M, Taggart P, Lambiase PD, Gourine A, Tinker A and Gourine AV (2018). Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1). Circ Arrhythm Electrophysiol  vol. 11, (10) e006740-e006740. 10.1161/CIRCEP.118.006740
Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A and Scambler PJ (2018). Defective Vagal Innervation in Murine Tbx1 Mutant Hearts. J Cardiovasc Dev Dis  vol. 5, (4) 10.3390/jcdd5040049
Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA, Huang CL-H, Ben Simon R, Tinker A and Lambiase PD (2018). Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome. Circ Arrhythm Electrophysiol  vol. 11, (9) e006330-e006330. 10.1161/CIRCEP.118.006330
(2018). P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker. European Heart Journal  vol. 39, (suppl_1) 10.1093/eurheartj/ehy566.p5709
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F and Ramirez J (2018). Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biology  vol. 19, (1) 10.1186/s13059-018-1457-6
Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A and Tinker A (2018). ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. Journal of Biological Chemistry  vol. 293, (23) 8912-8921. 10.1074/jbc.RA118.002775
Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA, Tinker A and Gourine AV (2018). A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow. Sage Publications  Journal of Cerebral Blood Flow and Metabolism  10.1177/0271678X18780602
Nobles M, Montaigne D, Sebastian S, Birnbaumer L and Tinker A (2018). Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K + currents in adult murine atria. American Journal of Physiology. Cell Physiology  vol. 314, (5) C616-C626. 10.1152/ajpcell.00271.2016
Tinker A, Finlay M, Nobles M and Opel A (2018). Erratum to “The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61](S1043661815301791)(10.1016/j.phrs.2015.11.008). Pharmacological Research  vol. 129, 10.1016/j.phrs.2018.02.019
Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD and Tinker A (2018). P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation. Ep Europace  vol. 20, (suppl_1) i87-i87. 10.1093/europace/euy015.258
Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE, Osumi-Sutherland D, Campbell NH, Huntley RP, Talmud PJ, Blake JA, Breckenridge R, Riley PR, Lambiase PD, Elliott PM, Clapp L, Tinker A and Hill DP (2018). Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology. Circ Genom Precis Med  vol. 11, (2) e001813-e001813. 10.1161/CIRCGEN.117.001813
Aziz Q, Li Y and Tinker A (2018). Endothelial biology and ATP-sensitive potassium channels. Channels (Austin, Tex.)  vol. 12, (1) 45-46. 10.1080/19336950.2017.1412151
Tinker A, Aziz Q, Li Y and Specterman M (2018). ATP-sensitive potassium channels and their physiological and pathophysiological roles. Comprehensive Physiology  vol. 8, (4) 1463-1511. 10.1002/cphy.c170048
Aziz Q, Li Y and Tinker A (2018). Potassium channels in the sinoatrial node and their role in heart rate control. Channels  vol. 12, (1) 356-366. 10.1080/19336950.2018.1532255
Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C, Tinker A, Harmer SC, Aziz Q, Terry A, Struebig M, Warren HR, Vadgama B, Fowler DJ, Peebles D, Taylor AM, Lally PJ and Thayyil S (2018). Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Circulation. Genomic and Precision Medicine  vol. 11, (1) 10.1161/CIRCGEN.117.001817
Orini M, Tinker A, Munroe PB and Lambiase PD (2018). Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Plos One  vol. 13, (2) e0193039-e0193039. 10.1371/journal.pone.0193039

2017

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD and Tinker A (2017). Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Research  vol. 25, 233-244. 10.1016/j.scr.2017.11.003
TINKER A and Lane J D (2017). Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology? Frontiers Media  Frontiers in Physiology  vol. 8, 10.3389/fphys.2017.00890
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG and Tarasova YS (2017). Mammalian γ2 AMPK regulates intrinsic heart rate. Macmillan Publications  Nat Commun  vol. 8, (1) 1258-1258. 10.1038/s41467-017-01342-5
Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E and Tinker A (2017). Molecular and functional characterization of the endothelial ATP-sensitive potassium channel. Journal of Biological Chemistry  vol. 292, (43) 17587-17597. 10.1074/jbc.M117.810325
Royal AA, Tinker A and Harmer SC (2017). Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking. Public Library of Science  Plos One  vol. 12, (10) e0186293-e0186293. 10.1371/journal.pone.0186293
Lane JD, Montaigne D and Tinker A (2017). Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. Journal of Membrane Biology  vol. 250, (5) 471-481. 10.1007/s00232-017-9973-y
Orini M, Tinker A, Munroe PB and Lambiase PD (2017). Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Public Library of Science  Plos One  vol. 12, (9) e0183732-e0183732. 10.1371/journal.pone.0183732
Tinker A (2017). The mechanisms of ventricular arrhythmia in Chagas disease. International Journal of Cardiology  vol. 240, 372-373. 10.1016/j.ijcard.2017.03.094
Munroe PB and Tinker A (2017). Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart  vol. 104, (1) 6-7. 10.1136/heartjnl-2017-311657
Finlay M, Harmer SC and Tinker A (2017). The control of cardiac ventricular excitability by autonomic pathways. Pharmacology and Therapeutics  vol. 174, 97-111. 10.1016/j.pharmthera.2017.02.023
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T, Guasti L and Dunkel L (2017). Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Molecular and Cellular Endocrinology  vol. 447, 12-22. 10.1016/j.mce.2017.02.030
MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H and Cabrera CP (2017). Discovery of novel heart rate-associated loci using the exome chip. Oxford University Press (Oup)  Human Molecular Genetics  10.1093/hmg/ddx113

2016

(2016). ORAL ABSTRACTS (1). Ep Europace  vol. 18, (suppl_2) ii4-ii7. 10.1093/europace/euw270
Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B, Simpson C, Klein G, Champagne J, Talajic M, Gardner M, Steinberg C, Janzen M, Arbour L, Green M, Angaran P, Roberts J, Leather R, Sanatani S, Chauhan V, Healey J, Krahn A, Taggart P, Srinivasan N, Hayward M, Lambiase PD, Aziz Q and Finlay MC (2016). YOUNG INVESTIGATORS COMPETITION1GENETIC ANALYSIS IN THE EVALUATION OF UNEXPLAINED CARDIAC ARREST: FROM THE CARDIAC ARREST SURVIVORS WITH PRESERVED EJECTION FRACTION REGISTRY (CASPER)2IN-VIVO WHOLE HEART CONTACT MAPPING DATA AND A SIMPLE MATHEMATICAL FRAMEWORK TO UNDERSTAND THE INTERACTIONS BETWEEN ACTIVATION AND REPOLARIZATION RESITUTION DYNAMICS IN THE INTACT HUMAN HEART3THE K(ATP) CHANNEL OPENER DIAZOXIDE REDUCES AUTOMATICITY IN AN IN VITRO ATRIAL CELL MODEL - POTENTIAL FOR K(ATP) CHANNELS AS A DRUG TARGE. Ep Europace  vol. 18, (suppl 2) ii1-ii3. 10.1093/europace/euw275
MUNROE PB (2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Publishing Group  Nature Genetics  10.1038/ng.3654
Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin JP and Varro A (2016). Human-based approaches to pharmacology and cardiology: An interdisciplinary and intersectorial workshop. Europace  vol. 18, (9) 1287-1298. 10.1093/europace/euv320
Ang R, Abramowitz J, Birnbaumer L, Gourine AV and Tinker A (2016). The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. Physiological Reports  vol. 4, (15) 10.14814/phy2.12860
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K (2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep  vol. 16, (4) 1026-1038. 10.1016/j.celrep.2016.06.050
Tinker A, Finlay M, Nobles M and Opel A (2016). The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation. Pharmacological Research  vol. 105, 54-61. 10.1016/j.phrs.2015.11.008
Harmer SC and Tinker A (2016). The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes. De Gruyter  Biol Chem  vol. 397, (7) 679-693. 10.1515/hsz-2015-0306
Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A and Baker JR (2016). Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines. Organic and Biomolecular Chemistry  vol. 14, (2) 455-459. 10.1039/c5ob02120k

2015

Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A, Marina N and Gourine AV (2015). Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Heart Rhythm  vol. 12, (11) 2285-2293. 10.1016/j.hrthm.2015.06.005
Munroe PB and Tinker A (2015). Genome-wide association studies and contribution to cardiovascular physiology. Physiological Genomics  vol. 47, (9) 365-375. 10.1152/physiolgenomics.00004.2015
Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A and Baker JR (2015). A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging. Organic and Biomolecular Chemistry  vol. 13, (37) 9559-9563. 10.1039/c5ob01468a
Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R and Tinker A (2015). Absence of the regulator of G-protein Signaling, RGS4, predisposes to atrial fibrillation and is associated with abnormal calcium handling. Journal of Biological Chemistry  vol. 290, (31) 19233-19244. 10.1074/jbc.M115.666719
Lambiase PD and Tinker A (2015). Connexins in the heart. Cell and Tissue Research  vol. 360, (3) 675-684. 10.1007/s00441-014-2020-8
Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A and Hussain K (2015). Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8. Human Molecular Genetics  vol. 24, (18) 5142-5153. 10.1093/hmg/ddv233
Notari M, Hu Y, Sutendra G, Dedei Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJP, Kelsell DP, De Noronha S, Sheppard MN, Hollinshead M, Mohun TJ and Lu X (2015). iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proceedings of The National Academy of Sciences of The United States of America  vol. 112, (9) E973-E981. 10.1073/pnas.1408111112
Aziz Q, Li Y and Tinker A (2015). ATP-sensitive potassium channels and vascular function. Channels  vol. 9, (1) 3-4. 10.1080/19336950.2015.1004289

2014

Lane JD, Abramowitz J, Birnbaumer L and Tinker A (2014). 51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure. Europace  vol. 16 Suppl 3, 10.1093/europace/euu241.1
Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L and Tinker A (2014). The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control. Hypertension  vol. 64, (3) 523-529. 10.1161/HYPERTENSIONAHA.114.03116
Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD and Tinker A (2014). Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1. Biochem J  vol. 462, (1) 133-142. 10.1042/BJ20140425
Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A and Baker JR (2014). Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. Organic & Biomolecular Chemistry  vol. 12, (4) 557-560. 10.1039/c3ob42141d
Tinker A, Aziz Q and Thomas A (2014). The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system. Br J Pharmacol  vol. 171, (1) 12-23. 10.1111/bph.12407
Arya VB, Aziz Q, Nessa A, Tinker A and Hussain K (2014). Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy. Int J Pediatr Endocrinol  vol. 2014, (1) 10.1186/1687-9856-2014-24

2013

Tinker A and Harmer SC (2013). Potassium channels regulating the electrical activity of the heart. Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment  10.1007/978-0-85729-920-8_6
Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K and Martemyanov KA (2013). Essential Role of the m(2)R-RGS6-I-KACh Pathway in Controlling Intrinsic Heart Rate Variability. Plos One  vol. 8, (10) 10.1371/journal.pone.0076973
Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L and Tinker A (2013). The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins. Am J Physiol Regul Integr Comp Physiol  vol. 305, (4) R435-R442. 10.1152/ajpregu.00037.2013
Ang R, Birnbaumer L, Gourine AV and Tinker A (2013). The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart. European Heart Journal  vol. 34, (suppl_1) p5030-p5030. 10.1093/eurheartj/eht310.p5030
Telezhkin V, Thomas AM, Harmer SC, Tinker A and Brown DA (2013). A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P-2. Pflugers Archiv-European Journal of Physiology  vol. 465, (7) 945-953. 10.1007/s00424-012-1199-3
Schwarzer S, Mashanov GI, Molloy JE and Tinker A (2013). Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly. Methods Mol Biol  vol. 998, 201-208. 10.1007/978-1-62703-351-0_15

2012

Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A and Ruhrberg C (2012). NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Developmental Biology  vol. 369, (2) 277-285. 10.1016/j.ydbio.2012.06.026
Tinker A and Harmer SC (2012). Potassium channels regulating the electrical activity of the heart. Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment  10.1007/978-0-85729-920-8_6
Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H, Davidson S, Zuberi Z, Tinker A, Shui B, Tallini YI, Kotlikoff MI, Miquerol L, Schwartz RJ and Riley PR (2012). Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Circ Res  vol. 111, (2) e19-e31. 10.1161/CIRCRESAHA.111.260695
Harmer SC, Mohal JS, Kemp D and Tinker A (2012). Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel. Biochem J  vol. 443, (3) 635-642. 10.1042/BJ20111912
Telezhkin V, Reilly JM, Thomas AM, Tinker A and Brown DA (2012). Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding. Journal of Biological Chemistry  vol. 287, (13) 10001-10012. 10.1074/jbc.M111.322552
Tinker A (2012). The assembly and targeting of potassium channels. Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels  10.1093/acprof:oso/9780192632241.003.0002
Aziz Q, Thomas AM, Khambra T and Tinker A (2012). Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C. J Biol Chem  vol. 287, (9) 6196-6207. 10.1074/jbc.M111.243923
Ang R, Opel A and Tinker A (2012). The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias. Front Physiol  vol. 3, 10.3389/fphys.2012.00096
Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, TINKER A and Lambiase PD (2012). Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Oxford University Press  Eur Heart Journal  vol. 33, (15) 1942-1953. 10.1093/eurheartj/ehr472

2011

Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A and Baker JR (2011). The design, synthesis and pharmacological characterization of novel β 2-adrenoceptor antagonists. British Journal of Pharmacology  vol. 164, (2) 317-331. 10.1111/j.1476-5381.2011.01269.x
(2011). In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells. Stem Cell Reviews and Reports  vol. 7, (2) 364-380. 10.1007/s12015-010-9200-z
Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S and Baker JR (2011). In situ maleimide bridging of disulfides and a new approach to protein PEGylation. Bioconjugate Chemistry  vol. 22, (2) 132-136. 10.1021/bc1004685
Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO and Shuba YM (2011). Sarcolemmal cardiac K ATP channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin. British Journal of Pharmacology  vol. 162, (3) 701-711. 10.1111/j.1476-5381.2010.01072.x
Thomas AM, Harmer SC, Khambra T and Tinker A (2011). Characterization of a binding site for anionic phospholipids on KCNQ1. Journal of Biological Chemistry  vol. 286, 2088-2100. 10.1074/jbc.M110.153551
Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A, Ellard S and Hussain K (2011). Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations. Diab Tologia  vol. 54, 2575-2583. 10.1007/s00125-011-2207-4

2010

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M and Segal AW (2010). Erratum: The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Nature (2004) 427 (853-858)). Nature  vol. 468, (7320) 10.1038/nature09562
Schwarzer S, Nobles M and Tinker A (2010). Do caveolae have a role in the fidelity and dynamics of receptor activation of G-protein-gated inwardly rectifying potassium channels? Journal of Biological Chemistry  vol. 285, (36) 27817-27826. 10.1074/jbc.M110.103598
Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L and Tinker A (2010). Absence of the inhibitory g-protein gαi2 predisposes to ventricular cardiac arrhythmia. Circulation: Arrhythmia and Electrophysiology  vol. 3, (4) 391-400. 10.1161/CIRCEP.109.894329
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A and Caddick S (2010). An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. Chemical Communications  vol. 46, (22) 3953-3954. 10.1039/c0cc00142b
Nobles M, Sebastian S and Tinker A (2010). HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes. Pflugers Archiv European Journal of Physiology  vol. 460, (1) 99-108. 10.1007/s00424-010-0799-z
Aziz Q, Thomas A, Khambra T and Tinker A (2010). Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel. European Journal of Pharmacology  vol. 634, (1-3) 26-32. 10.1016/j.ejphar.2010.02.023
Ng KE, Schwarzer S, Duchen MR and Tinker A (2010). The intracellular localization and function of the ATP-sensitive K + channel subunit Kir6.1. Journal of Membrane Biology  vol. 234, (2) 137-147. 10.1007/s00232-010-9241-x
Mashanov GI, Nobles M, Harmer SC, Molloy JE and Tinker A (2010). Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior. Journal of Biological Chemistry  vol. 285, 3664-3675. 10.1074/jbc.M109.039974
Tinker A and Harmer SC (2010). K+ channels in the heart: new insights and therapeutic implications. Expert Rev Clin Pharmacol  vol. 3, 305-319. 10.1586/ecp.10.14
Harmer SC, Wilson AJ, Aldridge R and Tinker A (2010). Mechanisms of disease pathogenesis in long QT syndrome type 5. Am J Physiol Cell Physiol  vol. 298, C263-C273. 10.1152/ajpcell.00308.2009

2009

Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJR, Tinker A and Mohun TJ (2009). Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice. Journal of Molecular and Cellular Cardiology  vol. 47, (1) 133-141. 10.1016/j.yjmcc.2009.04.007
Orie NN, Thomas AM, Perrino BA, Tinker A and Clapp LH (2009). Ca 2+/calcineurin regulation of cloned vascular K ATP channels: Crosstalk with the protein kinase a pathway. British Journal of Pharmacology  vol. 157, (4) 554-564. 10.1111/j.1476-5381.2009.00221.x

2008

Zuberi Z, Birnbaumer L and Tinker A (2008). The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics. American Journal of Physiology - Regulatory Integrative and Comparative Physiology  vol. 295, (6) 10.1152/ajpregu.90625.2008
Farzaneh T and Tinker A (2008). Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits. Cardiovascular Research  vol. 79, (4) 621-631. 10.1093/cvr/cvn138
Quinn KV, Behe P and Tinker A (2008). Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby. Journal of Physiology  vol. 586, (12) 2855-2871. 10.1113/jphysiol.2008.153791
Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AR, TINKER A and Duchen MR (2008). Regulation of mitochondrial structure and function by IF1, the endogenous inhibitor of the mitochondrial ATPase. Cell Metabolism  vol. 8, (1) 13-25. 10.1016/j.cmet.2008.06.001
Thomas AM and Tinker A (2008). Determination of phosphoinositide binding to K+ channel subunits using a protein-lipid overlay assay. Methods in Molecular Biology  vol. 491, 103-111. 10.1007/978-1-59745-526-8_8

2007

Hughes S, Marsh SJ, Tinker A and Brown DA (2007). PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: Direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons. Pflugers Archiv European Journal of Physiology  vol. 455, (1) 115-124. 10.1007/s00424-007-0259-6
Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG and Clapp LH (2007). IP receptor-dependent activation of PPARγ by stable prostacyclin analogues. Biochemical and Biophysical Research Communications  vol. 360, (4) 821-827. 10.1016/j.bbrc.2007.06.135
Harmer SC and Tinker A (2007). The role of abnormal trafficking of KCNE1 in long QT syndrome 5. Biochemical Society Transactions  vol. 35, 1074-1076. 10.1042/BST0351074
Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K and Tinker A (2007). Complex ABCC8 DNA variations in congenital hyperinsulinism: Lessons from functional studies. Clinical Endocrinology  vol. 67, (1) 115-124. 10.1111/j.1365-2265.2007.02847.x

2006

Tennant BP, Cui Y, Tinker A and Clapp LH (2006). Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: Evidence for a major role of Kir2.4 subunits. Journal of Membrane Biology  vol. 213, (1) 19-29. 10.1007/s00232-006-0037-y
Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG and Gaisano HY (2006). Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac KATP channel activation. Journal of Biological Chemistry  vol. 281, (28) 19019-19028. 10.1074/jbc.M513160200
Thomas AM, Brown SG, Leaney JL and Tinker A (2006). Differential phosphoinositide binding to components of the G protein-gated K+ channel. Journal of Membrane Biology  vol. 211, (1) 43-53. 10.1007/s00232-006-0014-5
Tinker A (2006). The selective interactions and functions of regulators of G-protein signalling. Seminars in Cell and Developmental Biology  vol. 17, (3) 377-382. 10.1016/j.semcdb.2006.03.007

2005

Nobles M, Benians A and Tinker A (2005). Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proceedings of The National Academy of Sciences of The United States of America  vol. 102, (51) 18706-18711. 10.1073/pnas.0504778102
Brown SG, Thomas A, Dekker LV, Tinker A and Leaney JL (2005). PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells. American Journal of Physiology - Cell Physiology  vol. 289, (3 58-3) 10.1152/ajpcell.00025.2005
Wilson AJ, Quinn KV, Graves FM, Bitner-Glindzicz M and Tinker A (2005). Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1). Cardiovascular Research  vol. 67, (3) 476-486. 10.1016/j.cardiores.2005.04.036
Benians A, Nobles M, Hosny S and Tinker A (2005). Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein: A novel explanation for the acceleration of signaling activation kinetics. Journal of Biological Chemistry  vol. 280, (14) 13383-13394. 10.1074/jbc.M410163200
Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong XY, Yoshida H, Nakamura TY, Artman M, Giblin JP, Tinker A and Coetzee WA (2005). Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Bmc Physiology  vol. 5, 10.1186/1472-6793-5-1

2004

Leaney JL, Benians A, Brown S, Nobles M, Kelly D and Tinker A (2004). Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle. American Journal of Physiology - Cell Physiology  vol. 287, (1 56-1) 10.1152/ajpcell.00540.2003
Quinn KV, Giblin JP and Tinker A (2004). Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K+ channel. Circulation Research  vol. 94, (10) 1359-1366. 10.1161/01.RES.0000128513.34817.c4
Ahluwalia J, Tinker A, Clapp LH, Buchen MR, Abramov AY, Pope S, Nobles M and Segal AW (2004). The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature  vol. 427, (6977) 853-858. 10.1038/nature02356

2003

Quinn KV, Cui Y, Giblin JP, Clapp LH and Tinker A (2003). Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? Circulation Research  vol. 93, (7) 646-655. 10.1161/01.RES.0000095247.81449.8E
Benians A, Leaney JL and Tinker A (2003). Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels. Proceedings of The National Academy of Sciences of The United States of America  vol. 100, (10) 6239-6244. 10.1073/pnas.1037595100
Cui Y, Tinker A and Clapp LH (2003). Different molecular sites of action for the K ATP channel inhibitors, PNU-99963 and PNU-37883A. British Journal of Pharmacology  vol. 139, (1) 122-128. 10.1038/sj.bjp.0705228
Benians A, Leaney JL, Milligan G and Tinker A (2003). The dynamics of formation and action of the ternary complex revealed in living cells using a G-protein-gated K+ channel as a biosensor. Journal of Biological Chemistry  vol. 278, (12) 10851-10858. 10.1074/jbc.M212299200

2002

Giblin JP, Quinn K and Tinker A (2002). The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking. European Journal of Biochemistry  vol. 269, (21) 5303-5313. 10.1046/j.1432-1033.2002.03249.x
Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R, Tinker A, Stephanou A, Knight RA and Latchman DS (2002). KATP channel gene expression is induced by urocortin and mediates its cardioprotective effect. Circulation  vol. 106, (12) 1556-1562. 10.1161/01.CIR.0000028424.02525.AE
Giblin JP, Cui Y, Clapp LH and Tinker A (2002). Assembly limits the pharmacological complexity of ATP-sensitive potassium channels. Journal of Biological Chemistry  vol. 277, (16) 13717-13723. 10.1074/jbc.M112209200
Cui Y, Tran S, Tinker A and Clapp LH (2002). The molecular composition of KATP channels in human pulmonary artery smooth muscle cells and their modulation by growth. American Journal of Respiratory Cell and Molecular Biology  vol. 26, (1) 135-143. 10.1165/ajrcmb.26.1.4622
Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ and Tinker A (2002). Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. American Journal of Respiratory Cell and Molecular Biology  vol. 26, (2) 194-201. 10.1165/ajrcmb.26.2.4695
Leaney JL, Benians A, Graves FM and Tinker A (2002). A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits. The Journal of Biological Chemistry  vol. 277, (32) 28803-28809. 10.1074/jbc.M204683200

2001

Leaney JL, Dekker LV and Tinker A (2001). Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca2+ -independent protein kinase C. Journal of Physiology  vol. 534, (2) 367-379. 10.1111/j.1469-7793.2001.00367.x
Cui Y, Giblin JP, Clapp LH and Tinker A (2001). A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits. Proceedings of The National Academy of Sciences of The United States of America  vol. 98, (2) 729-734. 10.1073/pnas.98.2.729
Huang L, Bitner-Glindzicz M, Tranebjærg L and Tinker A (2001). A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome. Cardiovascular Research  vol. 51, (4) 670-680. 10.1016/S0008-6363(01)00350-9

2000

Graves FM and Tinker A (2000). Functional expression of the pore forming subunit of the ATP-sensitive potassium channel in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications  vol. 272, (2) 403-409. 10.1006/bbrc.2000.2798
Leaney JL and Tinker A (2000). The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proceedings of The National Academy of Sciences of The United States of America  vol. 97, (10) 5651-5656. 10.1073/pnas.080572297
Leaney JL, Milligan G and Tinker A (2000). The G protein α subunit has a key role in determining the specificity of coupling to, but not the activation of, G protein-gated inwardly rectifying K+ channels. Journal of Biological Chemistry  vol. 275, (2) 921-929. 10.1074/jbc.275.2.921

1999

Tinker A and Jan LY (1999). Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels. Current Topics in Membranes and Transport  vol. 46, (C) 143-158. 10.1016/S0070-2161(08)60925-9
Giblin JP, Leaney JL and Tinker A (1999). The molecular assembly of ATP-sensitive potassium channels. Determinants on the pore forming subunit. Journal of Biological Chemistry  vol. 274, (32) 22652-22659. 10.1074/jbc.274.32.22652

1998

Clapp LH and Tinker A (1998). Potassium channels in the vasculature. Current Opinion in Nephrology and Hypertension  vol. 7, (1) 91-98. 10.1097/00041552-199801000-00015

1997

Welch W, Williams AJ, Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR, Besch HR, Airey JA, Sutko JL and Ruest L (1997). Structural components of ryanodine responsible for modulation of sarcoplasmic reticulum calcium channel function. Biochemistry  vol. 36, (10) 2939-2950. 10.1021/bi9623901

1996

Tinker A, Jan YN and Jan LY (1996). Regions responsible for the assembly of inwardly rectifying potassium channels. Cell  vol. 87, (5) 857-868. 10.1016/S0092-8674(00)81993-5
Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR, Besch HR and Williams AJ (1996). Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel. Biophysical Journal  vol. 70, (5) 2110-2119. 10.1016/S0006-3495(96)79777-1

1995

Tinker A and Williams AJ (1995). Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers. Biophysical Journal  vol. 68, (1) 111-120. 10.1016/S0006-3495(95)80165-7

1994

Lindsay ARG, Tinker A and Willams AJ (1994). How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca2+-release channel? Journal of General Physiology  vol. 104, (3) 425-447. 10.1085/jgp.104.3.425

1993

Tinker A and Williams AJ (1993). Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations. Journal of General Physiology  vol. 102, (6) 1107-1129. 10.1085/jgp.102.6.1107
Tinker A and Williams AJ (1993). Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel. Biophysical Journal  vol. 65, (4) 1678-1683. 10.1016/S0006-3495(93)81201-3
Tinker A, Lindsay ARG and Williams AJ (1993). Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions. Cardiovascular Research  vol. 27, (10) 1820-1825. 10.1093/cvr/27.10.1820
Tinker A and Williams AJ (1993). Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel. Biophysical Journal  vol. 65, (2) 852-864. 10.1016/S0006-3495(93)81104-4

1992

Tinker A and Williams AJ (1992). Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. Journal of General Physiology  vol. 100, (3) 479-493. 10.1085/jgp.100.3.479
Tinker A, Lindsay ARG and Williams AJ (1992). Block of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by tetra-alkyl ammonium cations. The Journal of Membrane Biology  vol. 127, (2) 149-159. 10.1007/BF00233287
Tinker A, Lindsay AR and Williams AJ (1992). Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel. Biophysical Journal  vol. 61, (5) 1122-1132. 10.1016/S0006-3495(92)81922-7
Tinker A, Lindsay ARG and Williams AJ (1992). A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. Journal of General Physiology  vol. 100, (3) 495-517. 10.1085/jgp.100.3.495

Grants

Grants of specific relevance to Predictive in vitro Models
Epigenetic mechanisms in atrial fibrillation - the role of developmental transcription factors and chronic stress
Villar Lozano D and Tinker A
£143,966 Barts Charity (01-11-2020 - 31-10-2024)
Summary
The genetic architecture of heart rate and the electrocardiogram at rest and during exercise
Munroe PB, Lambiase PD, Tinker A and Orini M
£600,142 Medical Research Council (03-01-2017 - 01-05-2020)
Summary


Characterisation of the physiological roles and pathological significance of endothelium-derived C-type natriuretic peptide: a novel vasoprotective signalling paradigm.
Hobbs AJ, Ahluwalia A and Tinker A
£476,952 Wellcome Trust (04-11-2008 - 03-07-2011)
Summary