Prof Andrew Tinker

Andrew Tinker
The William Harvey Research Institute
Queen Mary University of London
www.qmul.ac.uk/whri/people/academic-staff/items/tinkerandrew.html
ORCID

Research

iPSC, cardiomyocytes

Cardiovascular Models

Interests

An interest in iPSC models for cardiac disease modelling

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise
Ackland GL, Hosford PS, Gutierrez del Arroyo A, Korsak A, Machhada A, Pickard J, Gomez De La Torre GG, Stuckey DJ et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 137 (5), 702-704.  
15-08-2025
Heart Rate Profiles During Exercise and Incident Parkinson's Disease
van Duijvenboden S, Ramírez J, Scheurink J, Darweesh SKL, Orini M, Tinker A, Munroe PB, Thannhauser J et al.
Annals of Neurology, Wiley 
02-08-2025

2024

Prediction of atrial and ventricular arrhythmias using multiple cardiovascular risk-factor polygenic risk scores
Ramírez J, van Duijvenboden S, Orini M, Lambiase PD, Tinker A, Young WJ, Munroe PB
Heart Rhythm, Elsevier Bv 
01-12-2024
Cardiac autonomic function during exercise and incident Parkinson’s disease
van Duijvenboden S, Ramírez J, Scheurink J, Darweesh SKL, Orini M, Tinker A, Munroe PB, Thannhauser J et al.
In Cold Spring Harbor Laboratory 
08-11-2024
The genetic architecture of exercise-induced ventricular ectopy
Van Duijvenboden S, Nicholson G, Smith-Byrne K, Portas L, Atkins J, Ramirez J, Orini M, Young WJ et al.
European Heart Journal, Oxford University Press (Oup) vol. 45 (Supplement_1) 
28-10-2024
Circulating metabolites associate with the QT interval in individuals without prevalent cardiovascular disease
Young W, Sanghvi MM, Ramirez J, Orini M, Tinker A, Warren HR, Lambiase PD, Munroe PB
European Heart Journal, Oxford University Press (Oup) vol. 45 (Supplement_1) 
28-10-2024
Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal
Ramirez J, Martinez JP, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB et al.
European Heart Journal, Oxford University Press (Oup) vol. 45 (Supplement_1) 
28-10-2024
Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants
Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT et al.
Journal of The American Heart Association, Ovid Technologies (Wolters Kluwer Health) vol. 13 (17) 
03-09-2024
Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation
Vyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, Shahaj E, Fanti S et al.
Nature Cardiovascular Research, Springer Science and Business Media Llc vol. 3 (9), 1067-1082.  
23-08-2024
Fine mapping of candidate effector genes for heart rate
Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A et al.
Human Genetics, Springer Science and Business Media Llc vol. 143 (9-10), 1207-1221.  
06-07-2024
The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart
Tsisanova E, Nobles M, Sebastian S, Ng K-E, Thomas A, Weinstein LS, Munroe PB, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 300 (7), 107470-107470.  
01-07-2024
Identification and characterisation of functional Kir6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane
Brennan S, Chen S, Makwana S, Esposito S, McGuinness LR, Alnaimi AIM, Sims MW, Patel M et al.
British Journal of Pharmacology, Wiley vol. 181 (18), 3380-3400.  
19-05-2024
Transcriptional response of the heart to vagus nerve stimulation
Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A et al.
Physiological Genomics, American Physiological Society vol. 56 (2), 167-178.  
01-02-2024

2023

Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects
van Duijvenboden S, Ramírez J, Orini M, Aung N, Petersen SE, Doherty A, Tinker A, Munroe PB et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 148 (24), 1932-1944.  
12-12-2023
Transcriptional response of the heart to vagus nerve stimulation.
Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Del Arroyo AG, Crescente M, Tinker A et al.
Physiological Genomics vol. 56 (2), 167-178.  
04-12-2023
Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals without Cardiovascular Disease
Orini M, van Duijvenboden S, Ramírez J, Young W, Tinker A, Munroe P, Lambiase P
2023 Computing in Cardiology Conference. 
26-11-2023
A Multi-layer CNN Using the ECG, Age and Sex Predicts Ventricular Arrhythmias in the General Population
Ramírez J, Miguel A, van Duijvenboden S, Orini M, J. Young W, Tinker A, Lambiase P, B. Munroe P et al.
2023 Computing in Cardiology Conference. 
26-11-2023
Tissue-resident memory T cells in Epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in Atrial Fibrillation
Longhi P, Vyas V, Sandhar B, Wood E, Blythe H, Jones A, Shahaj E, Fanti S et al.
In Springer Science and Business Media Llc 
23-11-2023
Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population
Ramirez J, Martinez JP, Van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB, Miguel A
European Heart Journal, Oxford University Press (Oup) vol. 44 (Supplement_2) 
09-11-2023
Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease
Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB, Lambiase PD
European Heart Journal, Oxford University Press (Oup) vol. 44 (Supplement_2) 
09-11-2023
Long-term association of ultra-short heart rate variability with cardiovascular events
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB et al.
Scientific Reports, Springer Science and Business Media Llc vol. 13 (1) 
03-11-2023
GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al.
Cell Reports, Elsevier Bv vol. 42 (11), 113383-113383.  
01-11-2023
Hindering the progression of cardiac fibrosis in acromegaly - the role of somatostatin receptor ligands
Sanpawithayakul K, Mistry A, Rai A, Funge G, Sebastian S, Solomou A, Lillina VM, Gaston-Massuet C et al.
Endocrine Abstracts, Bioscientifica 
31-10-2023
Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels
Specterman MJ, Aziz Q, Li Y, Anderson NA, Ojake L, Ng K-E, Thomas AM, Finlay MC et al.
Circulation: Arrhythmia and Electrophysiology, Ovid Technologies (Wolters Kluwer Health) vol. 16 (9) 
01-09-2023
Abstract P2043: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A Myl2-independent Mechanism
Williams JL, Smith CJ, Mastroianni G, Stewart M, Cutillas P, Tinker A, Metherell L
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 133 (Suppl_1) 
04-08-2023
Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training
Korsak A, Kellett DO, Aziz Q, Anderson C, D’Souza A, Tinker A, Ackland GL, Gourine AV
Cardiovascular Research, Oxford University Press (Oup) vol. 119 (13), 2329-2341.  
30-07-2023
Long-term association of 15-second heart rate variability with cardiovascular events
Orini M, Duijvenboden SV, Young WJ, Ramírez J, Jones AR, Hughes A, Tinker A, Munroe PB et al.
In Research Square Platform Llc 
29-06-2023
BS18 Loss of full-length MYLK3 causes dilated cardiomyopathy via a MYL2-independent mechanism.
Williams J, Stewart M, Tinker A, Cutillas P, Metherell L
British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023. 
01-06-2023
BS69 Characterisation of in vivo and in vitro models for epigenomic investigations of cardiac hypertrophy
Fernández-Aroca D, Frost S, Tikkas G, Rodriguez A, Tinker A, Villar D
British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023. 
01-06-2023
BS56 An epigenomic investigation of atrial fibrillation in a paired left and right atrial cohort
Rodriguez A, Villar D, Frost S, Tinker A, Thomas A
British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023. 
01-06-2023
BS47 A comparative genomics approach reveals the interplay between epigenomic enhancer conservation and common genetic variation in the heart
Frost S, Parey E, Tinker A, Villar D
British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023. 
01-06-2023
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools
Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F et al.
Nature Communications, Springer Science and Business Media Llc vol. 14 (1) 
03-04-2023
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J et al.
Nature Communications, Springer Science and Business Media Llc vol. 14 (1) 
14-03-2023
Prognostic Significance of Different Ventricular Ectopic Burdens During Exercise in Asymptomatic UK Biobank Subjects
van Duijvenboden S, Ramírez J, Orini M, Doherty A, Tinker A, Munroe PB, Lambiase PD
In Cold Spring Harbor Laboratory 
06-03-2023
Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB, Lambiase PD
European Heart Journal - Digital Health, Oxford University Press (Oup) vol. 4 (2), 112-118.  
03-02-2023

2022

Uncoupling Between Heart Rate Variability and Heart Rate During Exercise and Recovery as a Predictor of Cardiovascular Events
Orini M, van Duijvenboden S, Ramirez J, Tinker A, Munroe P, Lambiase\ P
2022 Computing in Cardiology Conference. 
31-12-2022
\Association between photoplethysmography pulse upslope and cardiovascular events in over 170,000 UK Biobank participants\
Orini M, van Duijvenboden S, Tinker A, Munroe P, Lambiase\ P
2022 Computing in Cardiology Conference. 
31-12-2022
Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels
Bercea C, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell GS et al.
Frontiers in Physiology, Frontiers Media Sa vol. 13 
15-12-2022
Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion
Kwek X-Y, Hall AR, Lim W-W, Katwadi K, Soong PL, Grishina E, Lin K-H, Crespo-Avilan G et al.
Scientific Reports, Springer Science and Business Media Llc vol. 12 (1) 
06-12-2022
CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al.
Neuromuscular Disorders, Elsevier Bv vol. 32 (11-12), 908-922.  
01-12-2022
Investigating cardiomyocyte dysfunction in dilated cardiomyopathy associated with Duchenne muscular dystrophy
Wilson D, Tinker A, Iskratsch T
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 173, S18-S18.  
01-12-2022
Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy
Sebastian S, Weinstein LS, Ludwig A, Munroe P, Tinker A
Function, Oxford University Press (Oup) vol. 4 (1) 
01-11-2022
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors
Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB
Circulation: Genomic and Precision Medicine, Ovid Technologies (Wolters Kluwer Health) vol. 15 (5) 
01-10-2022
The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Wilson DGS, Tinker A, Iskratsch T
Communications Biology, Springer Science and Business Media Llc vol. 5 (1) 
27-09-2022
ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations
Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV et al.
Journal of The American Heart Association, Ovid Technologies (Wolters Kluwer Health) vol. 11 (17) 
06-09-2022
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al.
Nature Communications, Springer Science and Business Media Llc vol. 13 (1) 
01-09-2022
Abstract P2005: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A MYL2-independent Mechanism
Williams JL, Paudyal A, Stewart M, Cutillas P, Tinker A, Metherell L
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 131 (Suppl_1) 
05-08-2022
Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors
Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M, Munroe P
Atherosclerosis, Elsevier Bv vol. 355, 3-4.  
01-08-2022
Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels
Bercea C, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cotrell G et al.
In Wiley 
08-07-2022
BS11 Novel T-type calcium current pharmacology shows promise in the study of atrial fibrillation
Jones A, Tinker A
British Cardiovascular Society Annual Conference, ‘100 years of Cardiology’, 6–8 June 2022. 
01-06-2022
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools
Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Ortmann D, Lachmann M, Ortiz M et al.
In Cold Spring Harbor Laboratory 
30-05-2022
CRISPR-mediated correction of skeletal muscle Ca2+handling in a novel DMD patient-derived pluripotent stem cell model
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al.
In Cold Spring Harbor Laboratory 
18-02-2022
Prediction of coronary artery disease: Do risk factor genetic risk scores add value?
Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB
 
01-01-2022
Investigating the potential role of R-Ras in blood pressure control
Olczak K, Aziz Q, Sebastian S, Rajeeve V, Otunsola R, Tinker A, Munroe P
 
01-01-2022
The role of ATP-sensitive potassium channels in omega-3 polyunsaturated fatty acid-mediated vasodilation in mouse aorta and mesenteric arteries
Bercea CI, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell G et al.
 
01-01-2022
Investigating the potential role of the small GTPase R-Ras in mechanisms of blood pressure control
Olczak KJ, Aziz Q, Sebastian S, Tinker A, Munroe PB
 
01-01-2022

2021

Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models
Christensen SL, Rasmussen RH, Cour SL, Ernstsen C, Hansen TF, Kogelman LJA, Lauritzen SP, Guzaite G et al.
Cephalalgia, Sage Publications vol. 42 (2), 93-107.  
24-11-2021
Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice
Williams J, paudyal A, Stewart M, Cutillas P, Cox RD, Tinker A, Metherell L
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 144 (Suppl_1) 
16-11-2021
Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization
Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R et al.
In Cold Spring Harbor Laboratory 
04-11-2021
Acromegalic cardiomyopathy in pituitary-specific aryl hydrocarbon receptor interacting protein (Aip) gene knockout animals
Mistry A, Funge G, Sebastian S, Aziz Q, Solomou A, Vignola ML, Thong LC, Herincs M et al.
 
18-10-2021
Does knowledge of the mutation in hereditary long QT syndrome aid risk stratification?
Tinker A
European Heart Journal, Oxford University Press (Oup) vol. 42 (46), 4756-4758.  
20-09-2021
B-PO02-015 ENHANCING MUTANT IKSCHANNEL ACTIVITY BY ALTERING ENDOGENOUS PIP2 LEVELS AND ITS INTERACTION WITH PKA SIGNALLING PATHWAY
Rathod VSHS, Harmer S, Royal A, Aziz Q, Lambiase P, Tinker A
Heart Rhythm, Elsevier Bv vol. 18 (8), S101-S101.  
01-08-2021
Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders
van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB
Human Molecular Genetics, Oxford University Press (Oup) vol. 30 (24), 2513-2523.  
19-07-2021
Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy
Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G et al.
Cell and Tissue Research, Springer Science and Business Media Llc vol. 386 (1), 79-98.  
08-07-2021
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al.
Circulation: Genomic and Precision Medicine, Ovid Technologies (Wolters Kluwer Health) vol. 14 (3) 
01-06-2021
85 Prognostic value of premature ventricular complexes during exercise stress testing in 56,000 individuals without known structural heart disease from UK biobank: is a single ectopic prognostic?
van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe P, Lambiase P
British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021. 
01-06-2021
BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study
Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al.
British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021. 
01-06-2021
Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway
Rathod V, Harmer SC, Royal A, Aziz Q, Lambiase P, Tinker A
Ep Europace, Oxford University Press (Oup) vol. 23 (Supplement_3) 
24-05-2021
The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate
Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB, Tinker A
Physiological Genomics, American Physiological Society vol. 53 (4), 150-159.  
01-04-2021
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis
Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD et al.
Frontiers in Genetics, Frontiers Media Sa vol. 12 
18-02-2021
A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs
Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD, Orini M
Biomedical Signal Processing and Control, Elsevier Bv vol. 64, 102305-102305.  
01-02-2021
Analysing electrocardiographic traits and predicting cardiac risk in UK biobank
Ramírez J, Duijvenboden SV, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A
Jrsm Cardiovascular Disease, Sage Publications vol. 10 
01-01-2021
The Pharmacology of ATP-Sensitive K+ Channels (KATP)
Li Y, Aziz Q, Tinker A
, Springer International Publishing, 357-378.  
01-01-2021
Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors
Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB
 
01-01-2021
ATP-Dependent K+ Channels
Tinker A, Aziz Q, Li Y
In Encyclopedia of Molecular Pharmacology, Springer International Publishing 261-269.  
01-01-2021

2020

Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?
Young W, Ramírez J, van Duijvenboden S, Tinker A, Lambiase P, Munroe P, Orini M
2020 Computing in Cardiology Conference. 
30-12-2020
Interaction Between ECG and Genetic Markers of Coronary Artery Disease
Ramírez J, van Duijvenboden S, Young W, Tinker A, Lambiase P, Munroe P, Orini M
2020 Computing in Cardiology Conference. 
30-12-2020
Comparison of the spatial QRS-T angle With Intra-cardiac Markers of Depolarisation and Repolarisation
Young W, Srinivasan N, Tinker A, Munroe P, Lambiase P, Orini M
2020 Computing in Cardiology Conference. 
30-12-2020
Sex Differences in the Morphology of RR-Matched T-waves
Ramírez J, van Duijvenboden S, Tinker A, Lambiase P, Munroe P, Orini M
2020 Computing in Cardiology Conference. 
30-12-2020
Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate
van Duijvenboden S, Ramírez J, J. Young W, Tinker A, B. Munroe P, D. Lambiase P, Orini M
2020 Computing in Cardiology Conference. 
30-12-2020
Cardiac phenotype in\n ATP1A3\n -related syndromes
Balestrini S, Mikati MA, Álvarez-García-Rovés R, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L et al.
Neurology, Ovid Technologies (Wolters Kluwer Health) vol. 95 (21) 
24-11-2020
Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses
Ramírez J, Tinker A
Function, Oxford University Press (Oup) vol. 2 (1) 
09-11-2020
Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis
Li Y, Aziz Q, Anderson N, Ojake L, Tinker A
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 76 (3), 776-784.  
01-09-2020
Genetic Basis and Prognostic Value of Exercise QT Dynamics
van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD
Circulation: Genomic and Precision Medicine, Ovid Technologies (Wolters Kluwer Health) vol. 13 (4) 
01-08-2020
Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S et al.
Journal of Molecular Medicine, Springer Science and Business Media Llc vol. 98 (8), 1149-1160.  
06-07-2020
The contribution of non-coding regulatory elements to cardiovascular disease
Villar D, Frost S, Deloukas P, Tinker A
Open Biology, The Royal Society vol. 10 (7) 
01-07-2020
Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy
Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Tsisanova E, Walker SLM, Westaby JD et al.
In Cold Spring Harbor Laboratory 
26-06-2020
Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A
The American Journal of Human Genetics, Elsevier Bv vol. 106 (6), 764-778.  
01-06-2020
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al.
Nature Communications, Springer Science and Business Media Llc vol. 11 (1) 
21-05-2020
Mylk3null C57BL/6N mice develop cardiomyopathy, whereasNntnull C57BL/6J mice do not
Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV et al.
Life Science Alliance, Life Science Alliance, Llc vol. 3 (4), e201900593-e201900593.  
25-03-2020
The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on “The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome”
Aziz Q, Tinker A
Function, Oxford University Press (Oup) vol. 1 (1) 
01-01-2020
Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells
Aziz Q, Nobles M, Tinker A
Bio-Protocol, Bio-Protocol, Llc vol. 10 (1) 
01-01-2020
Acute Isolation of Cells from Murine Sino-atrial Node
Aziz Q, Nobles M, Tinker A
Bio-Protocol, Bio-Protocol, Llc vol. 10 (1) 
01-01-2020
ATP-Dependent K + Channels
Tinker A, Aziz Q, Li Y
In Encyclopedia of Molecular Pharmacology, Springer International Publishing 1-9.  
01-01-2020

2019

Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics
Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M et al.
Circulation: Arrhythmia and Electrophysiology, Ovid Technologies (Wolters Kluwer Health) vol. 12 (10) 
01-10-2019
Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome
Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA et al.
American Journal of Physiology-Cell Physiology, American Physiological Society vol. 317 (3), C576-C583.  
01-09-2019
Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function
Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A, Munroe PB
Human Molecular Genetics, Oxford University Press (Oup) vol. 29 (11), 1797-1807.  
19-08-2019
Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA et al.
Physiological Genomics, American Physiological Society vol. 51 (8), 323-332.  
01-08-2019
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction
Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al.
In Cold Spring Harbor Laboratory 
24-07-2019
Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM et al.
Journal of The American College of Cardiology, Elsevier Bv vol. 73 (24), 3118-3131.  
01-06-2019
21 The cardiovascular predictive value and genetic basis of T-wave morphology
Ramirez J, van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB
British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019. 
01-05-2019
22 Cardiac repolarization during exercise reveals independent prognostic information for cardiovascular risk prediction
van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe PB, Lambiase P
British Cardiovascular Society Annual Conference ‘Digital Health Revolution’ 3–5 June 2019. 
01-05-2019
DSP 突变与致心律失常性心肌病
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al.
British Journal of Dermatology, Oxford University Press (Oup) vol. 180 (5) 
26-04-2019
DSP mutations and arrhythmogenic cardiomyopathy
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al.
British Journal of Dermatology, Oxford University Press (Oup) vol. 180 (5) 
26-04-2019
Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D
Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A et al.
Frontiers in Physiology, Frontiers Media Sa vol. 10 
18-03-2019
Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method
Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A, Schilling RJ
Journal of Cardiovascular Electrophysiology, Wiley vol. 30 (5), 691-701.  
05-03-2019
Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM et al.
British Journal of Dermatology, Oxford University Press (Oup) vol. 180 (5), 1114-1122.  
02-01-2019
Using bioluminescent hiPSC reporter lines and high content screening to identify novel compounds for cardiomyocyte maturation
Scott ES, Awford J, Hyde R, Hassan M, Hashmi L, Harmer S, Fischer P, Kellam B et al.
 
01-01-2019
CRISPR/Cas9 genome editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al.
 
01-01-2019
Identification of novel loci for heart rate response to exercise and recovery
Ramirez J, van Duijvenboden S, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al.
 
01-01-2019
Cardiac Phenotype In ATP1A3 Related-Syndromes: A Multicentre Study
Balestrini S, Mikati M, Garcia-Roves RA, Carboni M, Hunanyan A, Kherallah B, McLean M, Prange L et al.
 
01-01-2019

2018

Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology
Ramírez J, van Duijvenboden S, Laguna P, Pueyo E, Tinker A, Lambiase P, Munroe P, Orini M
2018 Computing in Cardiology Conference. 
30-12-2018
ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles
Tinker A, Aziz Q, Li Y, Specterman M
Comprehensive Physiology, Wiley vol. 8 (4), 1463-1511.  
01-10-2018
Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1)
Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M et al.
Circulation: Arrhythmia and Electrophysiology, Ovid Technologies (Wolters Kluwer Health) vol. 11 (10) 
01-10-2018
23T-wave morphology restitution predicts arrhythmic risk in the UK biobank cohort
Ramírez J, van Duijvenboden S, Orini M, Tinker A, Munroe PB, Lambiase PD
Ep Europace vol. 20 (suppl_4), iv10-iv11.  
01-10-2018
2QT interval and exercise qt dynamics from 58,852 individuals in UK biobank predict ventricular arrhythmias and heart failure
van Duijvenboden S, Ramírez J, Orini M, Tinker A, Munroe PB, Lambiase PD
Ep Europace vol. 20 (suppl_4), iv1-iv1.  
01-10-2018
Defective Vagal Innervation in Murine Tbx1 Mutant Hearts
Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A, Scambler PJ
Journal of Cardiovascular Development and Disease, Mdpi Ag vol. 5 (4), 49-49.  
23-09-2018
ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles
Tinker A, Aziz Q, Li Y, Specterman M
, Wiley, 1463-1511.  
14-09-2018
Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome
Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA et al.
Circulation: Arrhythmia and Electrophysiology, Ovid Technologies (Wolters Kluwer Health) vol. 11 (9) 
01-09-2018
P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al.
European Heart Journal, Oxford University Press (Oup) vol. 39 (suppl_1) 
01-08-2018
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J et al.
Genome Biology, Springer Science and Business Media Llc vol. 19 (1) 
17-07-2018
A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow
Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA et al.
Journal of Cerebral Blood Flow &Amp; Metabolism, Sage Publications vol. 39 (10), 2089-2095.  
04-06-2018
ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia
Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 293 (23), 8912-8921.  
01-06-2018
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system
Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A et al.
Nature Communications, Springer Science and Business Media Llc vol. 9 (1) 
16-05-2018
CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al.
European Heart Journal, Oxford University Press (Oup) vol. 39 (43), 3879-3892.  
08-05-2018
Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria
Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A
American Journal of Physiology-Cell Physiology, American Physiological Society vol. 314 (5), C616-C626.  
01-05-2018
p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A et al.
Nature Communications, Springer Science and Business Media Llc vol. 9 (1) 
09-03-2018
Erratum to “The contribution of pathways initiated via the Gq\\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61]
Tinker A, Finlay M, Nobles M, Opel A
Pharmacological Research, Elsevier Bv vol. 129, 544-544.  
01-03-2018
P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation
Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD, Tinker A
Ep Europace, Oxford University Press (Oup) vol. 20 (suppl_1), i87-i87.  
01-03-2018
Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort
Orini M, Tinker A, Munroe PB, Lambiase PD
Plos One, Public Library of Science (Plos) vol. 13 (2), e0193039-e0193039.  
12-02-2018
Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology
Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE et al.
Circulation: Genomic and Precision Medicine, Ovid Technologies (Wolters Kluwer Health) vol. 11 (2) 
01-02-2018
Endothelial biology and ATP-sensitive potassium channels
Aziz Q, Li Y, Tinker A
Channels, Informa Uk Limited vol. 12 (1), 45-46.  
01-01-2018
Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths
Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C et al.
Circulation: Genomic and Precision Medicine, Ovid Technologies (Wolters Kluwer Health) vol. 11 (1) 
01-01-2018
Potassium channels in the sinoatrial node and their role in heart rate control
Aziz Q, Li Y, Tinker A
Channels, Informa Uk Limited vol. 12 (1), 356-366.  
01-01-2018
CRISPR/Cas9 gene editing in human pluripotent stem cell-cardiomyocytes provides a platform for modeling hypertrophic cardiomyopathy
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M et al.
 
01-01-2018
Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ et al.
 
01-01-2018

2017

Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR et al.
Stem Cell Research, Elsevier Bv vol. 25, 233-244.  
01-12-2017
Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?
Lane JD, Tinker A
Frontiers in Physiology, Frontiers Media Sa vol. 8 
06-11-2017
Mammalian γ2 AMPK regulates intrinsic heart rate
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV et al.
Nature Communications, Springer Science and Business Media Llc vol. 8 (1) 
02-11-2017
Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking
Royal AA, Tinker A, Harmer SC
Plos One, Public Library of Science (Plos) vol. 12 (10), e0186293-e0186293.  
11-10-2017
Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation
Lane JD, Montaigne D, Tinker A
 
01-10-2017
Molecular and functional characterization of the endothelial ATP-sensitive potassium channel
Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 292 (43), 17587-17597.  
01-10-2017
Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort
Orini M, Tinker A, Munroe PB, Lambiase PD
Plos One, Public Library of Science (Plos) vol. 12 (9), e0183732-e0183732.  
05-09-2017
The mechanisms of ventricular arrhythmia in Chagas disease
Tinker A
International Journal of Cardiology, Elsevier Bv vol. 240, 372-373.  
01-08-2017
Heritability of resting heart rate and association with mortality in middle-aged and elderly twins
Munroe PB, Tinker A
Heart, Bmj vol. 104 (1), 6-7.  
28-06-2017
The control of cardiac ventricular excitability by autonomic pathways
Finlay M, Harmer SC, Tinker A
Pharmacology &Amp; Therapeutics, Elsevier Bv vol. 174, 97-111.  
01-06-2017
227hERG potassium channel modulation by P127T KCNE1
Zhang Y, Marrion N, Harmer S, Mohamed R, Tinker A, Hancox J
Ep Europace, Oxford University Press (Oup) vol. 19 (suppl_3), iii22-iii22.  
01-06-2017
Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T et al.
Molecular and Cellular Endocrinology, Elsevier Bv vol. 447, 12-22.  
01-05-2017
Discovery of novel heart rate-associated loci using the Exome Chip
van den Berg ME, Warren HR, Cabrera CP, Verweij N, Mifsud B, Haessler J, Bihlmeyer NA, Fu Y-P et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 26 (12), 2346-2363.  
03-04-2017
Functional Studies of TRPM7 – a Candidate Gene for Stillbirth?
Cartwright J, Aziz Q, Harmer S, Tinker A, Munroe P
 
01-04-2017

2016

YOUNG INVESTIGATORS COMPETITION1GENETIC ANALYSIS IN THE EVALUATION OF UNEXPLAINED CARDIAC ARREST: FROM THE CARDIAC ARREST SURVIVORS WITH PRESERVED EJECTION FRACTION REGISTRY (CASPER)2IN-VIVO WHOLE HEART CONTACT MAPPING DATA AND A SIMPLE MATHEMATICAL FRAMEWORK TO UNDERSTAND THE INTERACTIONS BETWEEN ACTIVATION AND REPOLARIZATION RESITUTION DYNAMICS IN THE INTACT HUMAN HEART3THE K(ATP) CHANNEL OPENER DIAZOXIDE REDUCES AUTOMATICITY IN AN IN VITRO ATRIAL CELL MODEL - POTENTIAL FOR K(ATP) CHANNELS AS A DRUG TARGE
Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B et al.
Europace, Oxford University Press (Oup) vol. 18 (suppl 2), ii1-ii3.  
01-10-2016
ORAL ABSTRACTS (1)Allied Professionals7CRYOABLATION FOR PAROXYSMAL ATRIAL FIBRILLATION - IS AN EP LAB REQUIRED?8A PATHWAY TO SAFETY - ANTICOAGULATION COMPLIANCE IN CIED PATIENTS WITH AF9UNDERSTANDING THE WAYS IN WHICH OCCUPATION IS AFFECTED BY POSTURAL TACHYCARDIA SYNDROME: A UK OCCUPATIONAL THERAPY PERSPECTIVE10DEVELOPMENT OF AN INTERGRATED SUPPORT PATHWAY FOR PATIENTS FULFILLING NICE CRITERIA FOR AN INTERNAL CARDIOVASCULAR DEBRIBRILLATOR (ICD) IN A DISTRICT GENERAL HOSPITAL11ARE CARDIOVASCULAR RISK FACTOR
Champney F, Maddock LJ, Welford J, Kemp J, Allan V, Persidskikh Y, Orini M, Ang R et al.
Europace, Oxford University Press (Oup) vol. 18 (suppl 2), ii4-ii7.  
01-10-2016
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Nature Genetics, Springer Science and Business Media Llc vol. 48 (10), 1151-1161.  
12-09-2016
The role of GαO‐mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability
Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A
Physiological Reports, Wiley vol. 4 (15) 
01-08-2016
GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P et al.
Cell Reports, Elsevier Bv vol. 16 (4), 1026-1038.  
01-07-2016
57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation?
Zhou X, Harmer S, Bueno-Orovio A, Burrage K, Tinker A, Rodriguez B
Ep Europace, Oxford University Press (Oup) vol. 18 (suppl_1), i167-i167.  
01-06-2016
The contribution of pathways initiated via the Gq\\11 G-protein family to atrial fibrillation
Tinker A, Finlay M, Nobles M, Opel A
Pharmacological Research, Elsevier Bv vol. 105, 54-61.  
01-03-2016
The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes
Harmer SC, Tinker A
Biological Chemistry, Walter De Gruyter Gmbh vol. 397 (7), 679-693.  
23-02-2016
Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines
Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A, Baker JR
Organic &Amp; Biomolecular Chemistry, Royal Society of Chemistry (Rsc) vol. 14 (2), 455-459.  
01-01-2016
Loss of the inhibitory GalphaO protein in the rostral ventrolateral medulla of the brainstem leads to abnormalities in cardiovascular reflexes and altered ventricular excitablitiy
Ang R, Abramowitz J, Birnbaumer L, Gourine AV, Tinker A
 
01-01-2016

2015

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop
Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB et al.
Europace, Oxford University Press (Oup) vol. 18 (9), 1287-1298.  
29-11-2015
Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve
Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A et al.
Heart Rhythm, Elsevier Bv vol. 12 (11), 2285-2293.  
01-11-2015
Genome-wide association studies and contribution to cardiovascular physiology
Munroe PB, Tinker A
Physiological Genomics, American Physiological Society vol. 47 (9), 365-375.  
01-09-2015
Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling
Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 290 (31), 19233-19244.  
01-07-2015
Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations inABCC8
Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A, Hussain K
Human Molecular Genetics, Oxford University Press (Oup) vol. 24 (18), 5142-5153.  
19-06-2015
162 Simultaneous measurement of calcium transients and electrical activity in murine cardiac tissue – a novel system for the study of cardiac arrhythmia
Yeoh A, Finlay M, Anderson N, Harmer S, Tinker A
 
01-06-2015
iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death
Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA et al.
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 112 (9) 
17-02-2015
ATP-sensitive potassium channels and vascular function
Aziz Q, Li Y, Tinker A
Channels, Informa Uk Limited vol. 9 (1), 3-4.  
02-01-2015
A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging
Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A, Baker JR
Organic &Amp; Biomolecular Chemistry, Royal Society of Chemistry (Rsc) vol. 13 (37), 9559-9563.  
01-01-2015
Reduced activity of dorsal vagal preganglionic neurones associated with synuclein pathology predisposes the heart to ventricular arrhythmia
Machhada A, Ang R, Ackland G, Ninkina N, Buchman V, Lythgoe MF, Trapp S, Tinker A et al.
 
01-01-2015

2014

Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy
Arya VB, Aziz Q, Nessa A, Tinker A, Hussain K
International Journal of Pediatric Endocrinology, Springer Science and Business Media Llc vol. 2014 (1) 
01-12-2014
Connexins in the heart
Lambiase PD, Tinker A
Cell and Tissue Research, Springer Science and Business Media Llc vol. 360 (3), 675-684.  
31-10-2014
51 * Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure
Lane JD, Abramowitz J, Birnbaumer L, Tinker A
Europace, Oxford University Press (Oup) vol. 16 (suppl 3), iii20-iii20.  
01-10-2014
The ATP-Sensitive Potassium Channel Subunit, Kir6.1, in Vascular Smooth Muscle Plays a Major Role in Blood Pressure Control
Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L et al.
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 64 (3), 523-529.  
01-09-2014
Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1
Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD, Tinker A
Biochemical Journal, Portland Press Ltd. vol. 462 (1), 133-142.  
24-07-2014
Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence ‘turn-on’ reagents
Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A, Baker JR
Org. Biomol. Chem., Royal Society of Chemistry (Rsc) vol. 12 (4), 557-560.  
01-01-2014

2013

The role of ATP‐sensitive potassium channels in cellular function and protection in the cardiovascular system
Tinker A, Aziz Q, Thomas A
British Journal of Pharmacology, Wiley vol. 171 (1), 12-23.  
10-12-2013
Potassium channels regulating the electrical activity of the heart
Tinker A, Harmer SC
In Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment 89-109.  
01-11-2013
Essential Role of the m2R-RGS6-IKACh Pathway in Controlling Intrinsic Heart Rate Variability
Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA
Plos One, Public Library of Science (Plos) vol. 8 (10), e76973-e76973.  
29-10-2013
The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins
Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L, Tinker A
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, American Physiological Society vol. 305 (4), R435-R442.  
15-08-2013
The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart
Ang R, Birnbaumer L, Gourine AV, Tinker A
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl 1), P5030-P5030.  
02-08-2013
223 THE ROLE OF INHIBITORY G PROTEIN GALPHAO-MEDIATED SIGNALLING IN THE CENTRAL NERVOUS MECHANISMS CONTROLLING SYMPATHETIC OUTFLOW TO THE HEART
Ang R, Birnbaumer L, Gourine A, Tinker A
 
01-05-2013
A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P2
Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA
PflüGers Archiv - European Journal of Physiology, Springer Science and Business Media Llc vol. 465 (7), 945-953.  
06-01-2013
Using Total Internal Reflection Fluorescence Microscopy to Observe Ion Channel Trafficking and Assembly
Schwarzer S, Mashanov GI, Molloy JE, Tinker A
, Humana Press, 201-208.  
01-01-2013
The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart
Ang R, Birnbaumer L, Gourine AV, Tinker A
 
01-01-2013

2012

NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system
Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C
Developmental Biology, Elsevier Bv vol. 369 (2), 277-285.  
01-09-2012
Epistatic Rescue of Nkx2.5 Adult Cardiac Conduction Disease Phenotypes by Prospero-Related Homeobox Protein 1 and HDAC3
Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 111 (2) 
06-07-2012
Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel
Harmer SC, Mohal JS, Kemp D, Tinker A
Biochemical Journal, Portland Press Ltd. vol. 443 (3), 635-642.  
16-04-2012
Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding
Telezhkin V, Reilly JM, Thomas AM, Tinker A, Brown DA
Journal of Biological Chemistry, Elsevier Bv vol. 287 (13), 10001-10012.  
01-03-2012
Regulation of the ATP-sensitive Potassium Channel Subunit, Kir6.2, by a Ca2+-dependent Protein Kinase C
Aziz Q, Thomas AM, Khambra T, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 287 (9), 6196-6207.  
01-02-2012
Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study
Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M et al.
European Heart Journal, Oxford University Press (Oup) vol. 33 (15), 1942-1953.  
11-01-2012
The role of RGS4 in the electrophysiology of atrial cardiac myocytes
Nobles M, Sebastian S, Tinker A
 
01-01-2012
The KATP channel subunit, Kir6.2, is regulated by a Ca2+-dependent isoform of Protein Kinase C
Thomas AM, Aziz Q, Khambra T, Tinker A
 
01-01-2012
Mouse model for the conditional deletion of the KATP channel subunit Kir6.1 in vascular smooth muscle
Aziz Q, Khambra T, Sones W, Thomas AM, Kotlikoff M, Tinker A
 
01-01-2012
Rescue of long QT syndrome type 1 nonsense mutations by pharmacologically mediated readthrough
Harmer SC, Mohal JS, Kemp D, Tinker A
 
01-01-2012
Mice with conditional knockout of Galphai2 in the cardiac pacemaker system exhibit tachycardia with loss of HF power on HRV analysis
Ang R, Sebastian S, Ludwig A, Birnbaumer L, Tinker A
 
01-01-2012
The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias
Ang R, Opel A, Tinker A
Frontiers in Physiology, Frontiers Media Sa vol. 3 
01-01-2012

2011

Potassium Channels Regulating the Electrical Activity of the Heart
Tinker A, Harmer SC
In Translational Vascular Medicine, Springer London 89-109.  
06-10-2011
The design, synthesis and pharmacological characterization of novel β2-adrenoceptor antagonists
Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A, Baker JR
British Journal of Pharmacology, Wiley vol. 164 (2), 317-331.  
22-08-2011
Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations
Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A et al.
Diabetologia, Springer Science and Business Media Llc vol. 54 (10), 2575-2583.  
15-06-2011
In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation
Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S, Baker JR
Bioconjugate Chemistry, American Chemical Society (Acs) vol. 22 (2), 132-136.  
27-01-2011
Sarcolemmal cardiac KATPchannels as a target for the cardioprotective effects of the fluorine‐containing pinacidil analogue, flocalin
Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO, Shuba YM
British Journal of Pharmacology, Wiley vol. 162 (3), 701-711.  
12-01-2011
Characterization of a Binding Site for Anionic Phospholipids on KCNQ1
Thomas AM, Harmer SC, Khambra T, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 286 (3), 2088-2100.  
01-01-2011

2010

In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells
Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN et al.
Stem Cell Reviews and Reports, Springer Science and Business Media Llc vol. 7 (2), 364-380.  
01-12-2010
Retraction Note: The large-conductance Ca2+-activated K+ channel is essential for innate immunity
Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW
Nature, Springer Science and Business Media Llc vol. 468 (7320), 122-122.  
01-11-2010
ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent β‐Blocker ICI‐118,551 Allows the Determination of Enantiomer Dependency on Biological Activity.
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S
Cheminform, Wiley vol. 41 (43) 
30-09-2010
Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?
Schwarzer S, Nobles M, Tinker A
J Biol Chem vol. 285 (36), 27817-27826.  
03-09-2010
Absence of the Inhibitory G-Protein Gα\n i2\n Predisposes to Ventricular Cardiac Arrhythmia
Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L, Tinker A
Circulation: Arrhythmia and Electrophysiology, Ovid Technologies (Wolters Kluwer Health) vol. 3 (4), 391-400.  
01-08-2010
K+channels in the heart: new insights and therapeutic implications
Tinker A, Harmer SC
Expert Review of Clinical Pharmacology, Informa Uk Limited vol. 3 (3), 305-319.  
01-05-2010
Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel
Aziz Q, Thomas A, Khambra T, Tinker A
European Journal of Pharmacology, Elsevier Bv vol. 634 (1-3), 26-32.  
01-05-2010
The Intracellular Localization and Function of the ATP-Sensitive K+ Channel Subunit Kir6.1
Ng KE, Schwarzer S, Duchen MR, Tinker A
J Membrane Biol vol. 234 (2), 137-147.  
01-04-2010
HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes
Nobles M, Sebastian S, Tinker A
PflüGers Archiv - European Journal of Physiology, Springer Science and Business Media Llc vol. 460 (1), 99-108.  
26-02-2010
Direct Observation of Individual KCNQ1 Potassium Channels Reveals Their Distinctive Diffusive Behavior
Mashanov GI, Nobles M, Harmer SC, Molloy JE, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 285 (6), 3664-3675.  
01-02-2010
Mechanisms of disease pathogenesis in long QT syndrome type 5
Harmer SC, Wilson AJ, Aldridge R, Tinker A
American Journal of Physiology-Cell Physiology, American Physiological Society vol. 298 (2), C263-C273.  
01-02-2010
An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A, Caddick S
Chemical Communications, Royal Society of Chemistry (Rsc) vol. 46 (22), 3953-3953.  
01-01-2010

2009

Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice
Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI et al.
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 47 (1), 133-141.  
01-07-2009
Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway
Orie NN, Thomas AM, Perrino BA, Tinker A, Clapp LH
British Journal of Pharmacology, Wiley vol. 157 (4), 554-564.  
01-06-2009

2008

The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics
Zuberi Z, Birnbaumer L, Tinker A
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, American Physiological Society vol. 295 (6), R1822-R1830.  
01-12-2008
Regulation of Mitochondrial Structure and Function by the F1Fo-ATPase Inhibitor Protein, IF1
Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AY, Tinker A, Duchen MR
Cell Metabolism, Elsevier Bv vol. 8 (1), 13-25.  
01-07-2008
S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1
Campanella M, Tan C, Abramov A, Tinker A, Duchen M
Biochimica Et Biophysica Acta (Bba) - Bioenergetics, Elsevier Bv vol. 1777, S76-S76.  
01-07-2008
Monitoring changes in membrane phosphatidylinositol 4,5‐bisphosphate in living cells using a domain from the transcription factor tubby
Quinn KV, Behe P, Tinker A
The Journal of Physiology, Wiley vol. 586 (12), 2855-2871.  
15-06-2008
Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits
Farzaneh T, Tinker A
Cardiovascular Research, Oxford University Press (Oup) vol. 79 (4), 621-631.  
03-06-2008
Overexpression of the transcription factor Hand1 causes sudden cardiac death in mice
BRECKENRIDGE R, ZUBERI Z, FELKIN L, BIRKS E, BARTON P, TINKER A, MOHUN T
European Journal of Heart Failure Supplements, Oxford University Press (Oup) vol. 7, 109-109.  
01-06-2008
Determination of Phosphoinositide Binding to K+ Channel Subunits Using a Protein—Lipid Overlay Assay
Thomas AM, Tinker A
, Humana Press, 103-111.  
01-01-2008

2007

The role of abnormal trafficking of KCNE1 in long QT syndrome 5
Harmer SC, Tinker A
Biochemical Society Transactions, Portland Press Ltd. vol. 35 (5), 1074-1076.  
25-10-2007
IP receptor-dependent activation of PPARγ by stable prostacyclin analogues
Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG, Clapp LH
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 360 (4), 821-827.  
01-09-2007
Regulation of M(Kv7.2/7.3) channels in neurons by PIP2and products of PIP2hydrolysis: significance for receptor‐mediated inhibition
Brown DA, Hughes SA, Marsh SJ, Tinker A
 
21-07-2007
Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies
Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K, Tinker A
Clinical Endocrinology, Wiley vol. 67 (1), 115-124.  
27-04-2007
PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons
Hughes S, Marsh SJ, Tinker A, Brown DA
PflüGers Archiv - European Journal of Physiology, Springer Science and Business Media Llc vol. 455 (1), 115-124.  
20-04-2007

2006

Functional Expression of Inward Rectifier Potassium Channels in Cultured Human Pulmonary Smooth Muscle Cells: Evidence for a Major Role of Kir2.4 Subunits
Tennant BP, Cui Y, Tinker A, Clapp LH
Journal of Membrane Biology, Springer Science and Business Media Llc vol. 213 (1), 19-29.  
01-09-2006
Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic pH-induced Cardiac KATP Channel Activation
Kang Y, Ng B, Leung Y-M, He Y, Xie H, Lodwick D, Norman RI, Tinker A et al.
Journal of Biological Chemistry, Elsevier Bv vol. 281 (28), 19019-19028.  
01-07-2006
The selective interactions and functions of regulators of G-protein signalling
Tinker A
Seminars in Cell &Amp; Developmental Biology, Elsevier Bv vol. 17 (3), 377-382.  
01-06-2006
Differential Phosphoinositide Binding to Components of the G Protein-Gated K+ Channel
Thomas AM, Brown SG, Leaney JL, Tinker A
Journal of Membrane Biology, Springer Science and Business Media Llc vol. 211 (1), 43-53.  
01-05-2006

2005

Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
Nobles M, Benians A, Tinker A
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 102 (51), 18706-18711.  
13-12-2005
PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells
Brown SG, Thomas A, Dekker LV, Tinker A, Leaney JL
American Journal of Physiology-Cell Physiology, American Physiological Society vol. 289 (3), C543-C556.  
01-09-2005
Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1)
WILSON A, QUINN K, GRAVES F, BITNERGLINDZICZ M, TINKER A
Cardiovascular Research, Oxford University Press (Oup) vol. 67 (3), 476-486.  
15-08-2005
Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein
Benians A, Nobles M, Hosny S, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 280 (14), 13383-13394.  
01-04-2005
Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature
Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong X et al.
Bmc Physiology, Springer Science and Business Media Llc vol. 5 (1) 
12-01-2005

2004

Participation of RGS8 in the ternary complex of agonist, receptor and G-protein
Benians A, Nobles M, Tinker A
 
26-10-2004
Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle
Leaney JL, Benians A, Brown S, Nobles M, Kelly D, Tinker A
American Journal of Physiology-Cell Physiology, American Physiological Society vol. 287 (1), C182-C191.  
01-07-2004
Multisite Phosphorylation Mechanism for Protein Kinase A Activation of the Smooth Muscle ATP-Sensitive K\n +\n Channel
Quinn KV, Giblin JP, Tinker A
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 94 (10), 1359-1366.  
28-05-2004
The large-conductance Ca2+-activated K+ channel is essential for innate immunity
Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW
Nature, Springer Science and Business Media Llc vol. 427 (6977), 853-858.  
26-02-2004

2003

Do Anionic Phospholipids Serve as Cofactors or Second Messengers for the Regulation of Activity of Cloned ATP-Sensitive K\n +\n Channels?
Quinn KV, Cui Y, Giblin JP, Clapp LH, Tinker A
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 93 (7), 646-655.  
03-10-2003
Different molecular sites of action for the KATP channel inhibitors, PNU‐99963 and PNU‐37883A
Cui Y, Tinker A, Clapp LH
British Journal of Pharmacology, Wiley vol. 139 (1), 122-128.  
01-05-2003
Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K\n +\n channels
Benians A, Leaney JL, Tinker A
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 100 (10), 6239-6244.  
28-04-2003
The Dynamics of Formation and Action of the Ternary Complex Revealed in Living Cells Using a G-protein-gated K+ Channel as a Biosensor
Benians A, Leaney JL, Milligan G, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 278 (12), 10851-10858.  
01-03-2003

2002

The cytoplasmic C‐terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking
Giblin JP, Quinn K, Tinker A
European Journal of Biochemistry, Wiley vol. 269 (21), 5303-5313.  
17-10-2002
K\n ATP\n Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect
Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 106 (12), 1556-1562.  
17-09-2002
The assembly and targeting of potassium channels
Tinker A
In Receptor and Ion-Channel Traffickingcell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels, Oxford University Press 28-57.  
22-08-2002
A Novel Strategy to Engineer Functional Fluorescent Inhibitory G-protein α Subunits
Leaney JL, Benians A, Graves FM, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 277 (32), 28803-28809.  
01-08-2002
Assembly Limits the Pharmacological Complexity of ATP-sensitive Potassium Channels
Giblin JP, Cui Y, Clapp LH, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 277 (16), 13717-13723.  
01-04-2002
Differential Effects of Stable Prostacyclin Analogs on Smooth Muscle Proliferation and Cyclic AMP Generation in Human Pulmonary Artery
Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ, Tinker A
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society vol. 26 (2), 194-201.  
01-02-2002
The Molecular Composition of KATP Channels in Human Pulmonary Artery Smooth Muscle Cells and Their Modulation by Growth
Cui Y, Tran S, Tinker A, Clapp LH
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society vol. 26 (1), 135-143.  
01-01-2002

2001

A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome
Huang L
Cardiovascular Research, Oxford University Press (Oup) vol. 51 (4), 670-680.  
01-09-2001
Regulation of a G protein‐gated inwardly rectifying K+ channel by a Ca2+‐independent protein kinase C
Leaney JL, Dekker LV, Tinker A
The Journal of Physiology, Wiley vol. 534 (2), 367-379.  
01-07-2001
A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits
Cui Y, Giblin JP, Clapp LH, Tinker A
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 98 (2), 729-734.  
02-01-2001

2000

Functional Expression of the Pore Forming Subunit of the ATP-Sensitive Potassium Channel in Saccharomyces cerevisiae
Graves FM, Tinker A
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 272 (2), 403-409.  
01-06-2000
The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel
Leaney JL, Tinker A
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 97 (10), 5651-5656.  
25-04-2000
The G Protein α Subunit Has a Key Role in Determining the Specificity of Coupling to, but Not the Activation of, G Protein-gated Inwardly Rectifying K+ Channels
Leaney JL, Milligan G, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 275 (2), 921-929.  
01-01-2000

1999

The Molecular Assembly of ATP-sensitive Potassium Channels
Giblin JP, Leaney JL, Tinker A
Journal of Biological Chemistry, Elsevier Bv vol. 274 (32), 22652-22659.  
01-08-1999
Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels
Tinker A, Jan LY
, Elsevier, 143-158.  
01-01-1999

1998

Potassium channels in the vasculature
H L, Tinker A
Current Opinion in Nephrology and Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 7 (1), 83-98.  
01-01-1998

1997

Structural Components of Ryanodine Responsible for Modulation of Sarcoplasmic Reticulum Calcium Channel Function
Welch W, Williams AJ, Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR et al.
Biochemistry, American Chemical Society (Acs) vol. 36 (10), 2939-2950.  
01-03-1997

1996

Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels
Tinker A, Jan YN, Jan LY
Cell, Elsevier Bv vol. 87 (5), 857-868.  
01-11-1996
Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel
Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR et al.
Biophysical Journal, Elsevier Bv vol. 70 (5), 2110-2119.  
01-05-1996

1995

Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers
Tinker A, Williams AJ
Biophysical Journal, Elsevier Bv vol. 68 (1), 111-120.  
01-01-1995

1994

How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel?
Lindsay AR, Tinker A, Williams AJ
The Journal of General Physiology, Rockefeller University Press vol. 104 (3), 425-447.  
01-09-1994

1993

Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations.
Tinker A, Williams AJ
The Journal of General Physiology, Rockefeller University Press vol. 102 (6), 1107-1129.  
01-12-1993
Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel
Tinker A, Williams AJ
Biophysical Journal, Elsevier Bv vol. 65 (4), 1678-1683.  
01-10-1993
Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions
Tinker A, Lindsay ARG, Williams AJ
Cardiovascular Research, Oxford University Press (Oup) vol. 27 (10), 1820-1825.  
01-10-1993
Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel
Tinker A, Williams AJ
Biophysical Journal, Elsevier Bv vol. 65 (2), 852-864.  
01-08-1993

1992

Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum.
Tinker A, Williams AJ
The Journal of General Physiology, Rockefeller University Press vol. 100 (3), 479-493.  
01-09-1992
A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum.
Tinker A, Lindsay AR, Williams AJ
The Journal of General Physiology, Rockefeller University Press vol. 100 (3), 495-517.  
01-09-1992
Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel
Tinker A, Lindsay AR, Williams AJ
Biophysical Journal, Elsevier Bv vol. 61 (5), 1122-1132.  
01-05-1992
Block of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by tetra-alkyl ammonium cations
Tinker A, Lindsay AG, Williams A
The Journal of Membrane Biology, Springer Science and Business Media Llc vol. 127 (2) 
01-04-1992
A model for ionic conduction in the sheep cardiac ryanodine receptor-channel
Tinker A, Lindsay ARG, Williams AJ
 
01-01-1992

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconDoes AIP Haploinsufficiency Aggravate Acromegalic Heart Disease (Revised)
Marta Korbonits, Andrew Tinker, Gabor Czibik and Federica Begalli
£349,768 Barts and the London Charity
06-08-2025 - 05-08-2028
bullet iconBHF Programme grant renewal
Gareth Ackland, Andrew Tinker and Stuart Miller
£576,224 British Heart Foundation
01-07-2025 - 30-06-2030
solid heart iconThe role of novel mechanosensitive complex in cardiomyocyte pathophysiology
Thomas Iskratsch and Andrew Tinker
£254,588 BHF British Heart Foundation
01-10-2024 - 30-09-2027
bullet iconThe cardiovascular function of the orphan G-protein coupled receptor GPR20
Andrew Tinker, Peter McCormick, Arianna Fornili and Patricia Munroe
£307,773 BHF British Heart Foundation
01-05-2023 - 30-04-2026

bullet iconDeveloping novel antibody tools to modulate GPR20
Andrew Tinker, Arianna Fornili, Ahuva Nissim and Peter McCormick
£74,767 Barts and the London Charity
01-02-2024 - 30-06-2025
solid heart iconThe role of MYLK3 in cardiac signalling and development
Lou Metherell, Jack Williams, Andrew Tinker and Pedro Rodriguez Cutillas
£304,103 BHF British Heart Foundation
01-02-2022 - 30-07-2025
bullet iconEpigenetic mechanisms in atrial fibrillation
Diego Villar Lozano and Andrew Tinker
£150,981 Barts and the London Charity
01-11-2020 - 30-04-2025
bullet iconResistance to inhibitors of cholinesterase 8B and regulation of cardiovascular function
Andrew Tinker, Patricia Munroe and Muriel Nobles
£159,710 BHF British Heart Foundation
01-10-2020 - 16-06-2023
bullet iconCardic Vagus and Exercise in Health Disease
Gareth Ackland and Andrew Tinker
£429,815 BHF British Heart Foundation
01-12-2019 - 30-06-2025
bullet iconRoles of Endothelial and Smooth Muscle KATP channels in Myocardial Ischemic Injury
Andrew Tinker
£325,938 NIH National Institutes of Health - USA
01-12-2019 - 30-11-2024
bullet iconPathways of calcium signalling in atrial fibrillation highlighted by genomic and transcriptomic studies
Andrew Tinker and Patricia Munroe
£248,445 MRC Medical Research Council
01-10-2019 - 31-01-2023
bullet iconThe effects of polyunsaturated fatty acids on ATP sensitive potassium channels
Andrew Tinker
£19,265 British Heart Foundation
02-09-2019 - 02-09-2022
bullet iconiRhom2 and the keratinocyte stress response in health and disease
David Kelsell and Andrew Tinker
£559,364 MRC Medical Research Council
01-04-2019 - 31-08-2023
bullet iconA modulator of heterotrimeric G-protein signalling and its role in cardiovascular physiology
Andrew Tinker
£145,984 BHF British Heart Foundation
01-11-2017 - 31-10-2019
bullet iconCRISPR/Cas9 Engineered Human iPSC Models for Muscular Dystrophy Research
Yung-Yao Lin and Andrew Tinker
£490,000 Pfizer Global Pharmaceuticals
14-06-2017 - 31-12-2020
bullet iconCoupling gene targeted reporters with fully automated compound library screening to mature hPSC-cardiomyocytes
Andrew Tinker
£169,018 BHF British Heart Foundation
01-01-2017 - 31-12-2019
bullet iconAdrenergic regulation of IKs and impairment in the hereditary long QT syndrome
Andrew Tinker
£212,655 BHF British Heart Foundation
03-08-2016 - 02-08-2019
bullet iconRole of the ATPsensitive potassium channels in cardiovascular physiology and disease
Andrew Tinker
£1,101,688 BHF British Heart Foundation
01-01-2016 - 31-05-2021
bullet iconUnderstanding vagal control of the left ventricle
Andrew Tinker
£359,470 BHF British Heart Foundation
01-10-2015 - 31-03-2020