Publications

Publications of specific relevance to Predictive in vitro Models
2023

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J, Garnier S, van Duijvenboden S, Baldassari AR, Concas MP, Duong T, Foco L, Isaksen JL, Mei H, Noordam R, Nursyifa C, Richmond A, Santolalla ML, Sitlani CM, Soroush N, Thériault S, Trompet S, Aeschbacher S, Ahmadizar F, Alonso A, Brody JA, Campbell A and Correa A (2023).
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nat Commun vol. 14, (1)
10.1038/s41467-023-36997-w
Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR,
Tinker A, Munroe PB and Lambiase PD (2023).
Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events. European Heart Journal - Digital Health 10.1093/ehjdh/ztad007
Sebastian S, Weinstein LS, Ludwig A, Munroe P and
Tinker A (2023).
Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy. Function (Oxf) vol. 4, (1)
10.1093/function/zqac0552022

Bercea C, Limbu R, Behnam K, Ng KE, Aziz Q,
Tinker A, Tamagnini F, Cottrell GS and McNeish AJ (2022).
Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels. Frontiers in Physiology vol. 13,
10.3389/fphys.2022.1033216
Young WJ, Lahrouchi N, Isaacs A, Duong TV, Foco L, Ahmed F, Brody JA, Salman R, Noordam R, Benjamins JW, Haessler J, Lyytikäinen LP, Repetto L, Concas MP, van den Berg ME, Weiss S, Baldassari AR, Bartz TM, Cook JP, Evans DS, Freudling R, Hines O, Isaksen JL, Lin H, Mei H, Moscati A, Müller-Nurasyid M, Nursyifa C, Qian Y and Richmond A (2022).
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nature Communications vol. 13, (1)
10.1038/s41467-022-32821-z
Wilson D,
Tinker A and Iskratsch T (2022).
Investigating cardiomyocyte dysfunction in dilated cardiomyopathy associated with Duchenne muscular dystrophy. Journal of Molecular and Cellular Cardiology vol. 173,
10.1016/j.yjmcc.2022.08.038
Kwek XY, Hall AR, Lim WW, Katwadi K, Soong PL, Grishina E, Lin KH, Crespo-Avilan G, Yap EP, Ismail NI, Chinda K, Chung YY, Wei H, Shim W, Montaigne D,
Tinker A, Ong SB and Hausenloy DJ (2022).
Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion. Scientific Reports vol. 12, (1)
10.1038/s41598-022-25625-0
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J, Garren S, Liu P, Morgan JE, Muntoni F, Christoforou N, Owens J,
Tinker A and
Lin Y-Y (2022).
CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model. Neuromuscular Disorders 10.1016/j.nmd.2022.10.007
Ramírez J, Van Duijvenboden S, Young WJ,
Tinker A, Lambiase PD, Orini M and Munroe PB (2022).
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors. Circulation: Genomic and Precision Medicine vol. 15, (5) 444-452.
10.1161/CIRCGEN.121.003441
Ramírez J, Kiviniemi A, van Duijvenboden S,
Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV, Orini M and Munroe PB (2022).
ECG T-Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low-and Moderate-Risk Populations. Journal of The American Heart Association vol. 11, (17)
10.1161/JAHA.121.025897
Williams JL, Paudyal A, Stewart M, Cutillas P,
Tinker A and
Metherell L (2022).
Abstract P2005: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A MYL2-independent Mechanism. Circulation Research vol. 131, (Suppl_1) ap2005-ap2005.
10.1161/res.131.suppl_1.p2005
Ramírez J, Van Duijvenboden S, Young W,
Tinker A, Lambiase P, Orini M and Munroe P (2022).
Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors. Atherosclerosis vol. 355, 3-4.
10.1016/j.atherosclerosis.2022.06.012
Christensen SL, Rasmussen RH, Cour SL, Ernstsen C, Hansen TF, Kogelman LJA, Lauritzen SP, Guzaite G, Styrishave B, Janfelt C, Christensen ST, Aziz Q,
Tinker A, Jansen-Olesen I, Olesen J and Kristensen DM (2022).
Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models. Cephalalgia vol. 42, (2) 93-107.
10.1177/033310242110535702021

Van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B,
Tinker A, Lambiase PD and Munroe PB (2021).
Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders. Human Molecular Genetics vol. 30, (24) 2513-2523.
10.1093/hmg/ddab197
Tinker A (2021).
Does knowledge of the mutation in hereditary long QT syndrome aid risk stratification? European Heart Journal vol. 42, (46) 4756-4758.
10.1093/eurheartj/ehab668
Williams J, paudyal A, Stewart M, Cutillas P, Cox RD,
Tinker A and
Metherell L (2021).
Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice. Circulation vol. 144, (Suppl_1) a14037-a14037.
10.1161/circ.144.suppl_1.14037
Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G, Walker SLM, Westaby JD,
Pennington DJ, Pink R,
Kelsell DP and
Tinker A (2021).
Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy. Cell and Tissue Research vol. 386, (1) 79-98.
10.1007/s00441-021-03488-7
Rathod VSHS, Harmer S, Royal A, Aziz Q, Lambiase P and
Tinker A (2021).
B-PO02-015 ENHANCING MUTANT I KSCHANNEL ACTIVITY BY ALTERING ENDOGENOUS PIP2 LEVELS AND ITS INTERACTION WITH PKA SIGNALLING PATHWAY. Heart Rhythm vol. 18, (8)
10.1016/j.hrthm.2021.06.272
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, Van Duijvenboden S, Orini M,
Tinker A, Van Heemst D, Lambiase PD, Jukema JW, Munroe PB and Noordam R (2021).
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank. Circulation: Genomic and Precision Medicine vol. 14, (3)
10.1161/CIRCGEN.120.003231
Rathod V, Harmer S, Royal A, Aziz Q, Lambiase P and
Tinker A (2021).
Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway. Ep Europace vol. 23, (Supplement_3)
10.1093/europace/euab116.543
Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD,
Tinker A, Marouli E, Munroe PB and Ramírez J (2021).
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis. Frontiers in Genetics vol. 12,
10.3389/fgene.2021.569323
Cartwright JH, Aziz Q, Harmer SC, Thayyil S,
Tinker A and Munroe PB (2021).
Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function. Human Molecular Genetics vol. 29, (5) 1797-1807.
10.1093/HMG/DDZ198
Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB and
Tinker A (2021).
The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate. Physiological Genomics vol. 53, (4) 150-159.
10.1152/physiolgenomics.00157.2020
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB and
Tinker A (2021).
Analysing electrocardiographic traits and predicting cardiac risk in UK biobank. Jrsm Cardiovasc Dis vol. 10,
10.1177/204800402110236642020

Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A and Morris AP (2020).
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications vol. 11, (1)
10.1038/s41467-020-15706-x
Young WJ, van Duijvenboden S, Ramírez J, Jones A,
Tinker A, Munroe PB, Lambiase PD and Orini M (2020).
A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs. Elsevier Biomedical Signal Processing and Control vol. 64,
10.1016/j.bspc.2020.102305
Balestrini S, Mikati MA, Garcia-Roves RA, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L, De Grandis E, Gagliardi A, Pisciotta L, Stagnaro M, Veneselli E, Campistol J, Fons C, Pias-Peleteiro L, Brashear A, Miller C, Samoes R, Brankovic V, Padiath QS, Potic A, Pilch J, Vezyroglou K, Bye AME, Davis AM, Ryan MM, Semsarian C, Hollingsworth G and Scheffer IE (2020).
Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study. American Academy of Neurology Neurology 10.1212/WNL.0000000000010794
Van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M,
Tinker A, Munroe PB and Lambiase PD (2020).
Genetic Basis and Prognostic Value of Exercise QT Dynamics. Circulation: Genomic and Precision Medicine vol. 13, (4)
10.1161/CIRCGEN.119.002774
Li Y, Aziz Q, Anderson N, Ojake L and
Tinker A (2020).
Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis. American Heart Association Hypertension HYPERTENSIO-HYPERTENSIO.
10.1161/HYPERTENSIONAHA.120.15355
Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S,
Hobbs AJ, Thiemermann C and
Tinker A (2020).
Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Springer Science and Business Media Llc Journal of Molecular Medicine 10.1007/s00109-020-01946-3
Villar D, Frost S, Deloukas P and
Tinker A (2020).
The contribution of non-coding regulatory elements to cardiovascular disease. The Royal Society Open Biology vol. 10, (7) 200088-200088.
10.1098/rsob.200088
Aziz Q and
Tinker A (2020).
The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. Oup Function vol. 1, (1) zqaa005-zqaa005.
10.1093/function/zqaa005
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB and
Tinker A (2020).
Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. American Journal of Human Genetics vol. 106, (6) 764-778.
10.1016/j.ajhg.2020.04.009
Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV, Stewart M,
Tinker A, Cox RD and
Metherell LA (2020).
Mylk3 null c57bl/6n mice develop cardiomyopathy, whereas nnt null c57bl/6j mice do not. Life Science Alliance vol. 3, (4)
10.26508/LSA.201900593
Aziz Q, Nobles M and
Tinker A (2020).
Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells. Bio Protoc vol. 10, (1)
10.21769/BioProtoc.34782019

Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E,
Tinker A, Lambiase PD, Orini M and Munroe PB (2019).
Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics. American Heart Association Circulation: Arrhythmia and Electrophysiology vol. 12, (10) e007549-e007549.
10.1161/CIRCEP.119.007549
Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA, Barnes MR, Munroe PB and
Tinker A (2019).
Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages. Physiol Genomics vol. 51, (8) 323-332.
10.1152/physiolgenomics.00012.2019
Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA, Huang CL-H, Lambiase PD and
Tinker A (2019).
Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome. Am J Physiol Cell Physiol 10.1152/ajpcell.00028.2019
Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen LP, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA, Shah N, Schramm K, Vidigal PG, Weiss S and Yao J (2019).
Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. Journal of The American College of Cardiology vol. 73, (24) 3118-3131.
10.1016/j.jacc.2019.03.519
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD,
Tinker A, McKenna WJ and
Kelsell DP (2019).
Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype. British Journal of Dermatology vol. 180, (5) 1114-1122.
10.1111/bjd.17388
Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E,
Tinker A and Schilling RJ (2019).
Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method. Journal of Cardiovascular Electrophysiology vol. 30, (5) 691-701.
10.1111/jce.13882
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD,
Tinker A, McKenna WJ and
Kelsell DP (2019).
DSP 突变与致心律失常性心肌病. British Journal of Dermatology vol. 180, (5) e169-e169.
10.1111/bjd.17808
Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD,
Tinker A, McKenna WJ and
Kelsell DP (2019).
DSP mutations and arrhythmogenic cardiomyopathy. British Journal of Dermatology vol. 180, (5) e157-e157.
10.1111/bjd.17796
Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K,
Tinker A, Rodriguez B and Harmer SC (2019).
Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D. Front Physiol vol. 10, 259-259.
10.3389/fphys.2019.002592018

Calmont A, Anderson N, Suntharalingham JP, Ang R,
Tinker A and Scambler PJ (2018).
Defective vagal innervation in murine TBX1 mutant hearts. Journal of Cardiovascular Development and Disease vol. 5, (4)
10.3390/jcdd5040049
Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M,
Tinker A, Lambiase PD and Munroe PB (2018).
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system. Nature Communications vol. 9, (1)
10.1038/s41467-018-04148-1
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC,
Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A and Denning C (2018).
CRISPR/Cas9 editing in human pluripotent stemcell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. European Heart Journal vol. 39, (43) 3879-3892.
10.1093/eurheartj/ehy249
Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M, Taggart P, Lambiase PD, Gourine A,
Tinker A and Gourine AV (2018).
Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1). Circ Arrhythm Electrophysiol vol. 11, (10) e006740-e006740.
10.1161/CIRCEP.118.006740
Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA, Huang CL-H, Ben Simon R,
Tinker A and Lambiase PD (2018).
Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome. Circ Arrhythm Electrophysiol vol. 11, (9) e006330-e006330.
10.1161/CIRCEP.118.006330
Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ,
Tinker A, McKenna WJ and
Kelsell DP (2018).
P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker. European Heart Journal vol. 39, (suppl_1)
10.1093/eurheartj/ehy566.p5709
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F and Ramirez J (2018).
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biology vol. 19, (1)
10.1186/s13059-018-1457-6
Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A and
Tinker A (2018).
ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. Journal of Biological Chemistry vol. 293, (23) 8912-8921.
10.1074/jbc.RA118.002775
Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA,
Tinker A and Gourine AV (2018).
A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow. Sage Publications Journal of Cerebral Blood Flow and Metabolism 10.1177/0271678X18780602
Nobles M, Montaigne D, Sebastian S, Birnbaumer L and
Tinker A (2018).
Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+currents in adult murine atria. American Journal of Physiology - Cell Physiology vol. 314, (5) C616-C626.
10.1152/AJPCELL.00271.2016
Tinker A, Finlay M, Nobles M and Opel A (2018).
Erratum to “The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61](S1043661815301791)(10.1016/j.phrs.2015.11.008). Pharmacological Research vol. 129,
10.1016/j.phrs.2018.02.019
Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD and
Tinker A (2018).
P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation. Ep Europace vol. 20, (suppl_1) i87-i87.
10.1093/europace/euy015.258
Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE, Osumi-Sutherland D, Campbell NH, Huntley RP, Talmud PJ, Blake JA, Breckenridge R, Riley PR, Lambiase PD, Elliott PM, Clapp L,
Tinker A and Hill DP (2018).
Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology. Circ Genom Precis Med vol. 11, (2) e001813-e001813.
10.1161/CIRCGEN.117.001813
Tinker A, Aziz Q, Li Y and Specterman M (2018).
ATP-sensitive potassium channels and their physiological and pathophysiological roles. Comprehensive Physiology vol. 8, (4) 1463-1511.
10.1002/cphy.c170048
Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C,
Tinker A, Harmer SC, Aziz Q, Terry A, Struebig M, Warren HR, Vadgama B, Fowler DJ, Peebles D, Taylor AM, Lally PJ and Thayyil S (2018).
Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Circulation: Genomic and Precision Medicine vol. 11, (1)
10.1161/CIRCGEN.117.001817
Orini M,
Tinker A, Munroe PB and Lambiase PD (2018).
Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Plos One vol. 13, (2) e0193039-e0193039.
10.1371/journal.pone.01930392017

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD and
Tinker A (2017).
Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Stem Cell Research vol. 25, 233-244.
10.1016/j.scr.2017.11.003
TINKER A and Lane J D (2017).
Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology? Frontiers Media Frontiers in Physiology vol. 8,
10.3389/fphys.2017.00890
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG and Tarasova YS (2017).
Mammalian γ2 AMPK regulates intrinsic heart rate. Macmillan Publications Nat Commun vol. 8, (1) 1258-1258.
10.1038/s41467-017-01342-5
Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E and
Tinker A (2017).
Molecular and functional characterization of the endothelial ATP-sensitive potassium channel. Journal of Biological Chemistry vol. 292, (43) 17587-17597.
10.1074/jbc.M117.810325
Royal AA,
Tinker A and Harmer SC (2017).
Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking. Public Library of Science Plos One vol. 12, (10) e0186293-e0186293.
10.1371/journal.pone.0186293
Lane JD, Montaigne D and
Tinker A (2017).
Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. Journal of Membrane Biology vol. 250, (5) 471-481.
10.1007/s00232-017-9973-y
Orini M,
Tinker A, Munroe PB and Lambiase PD (2017).
Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Public Library of Science Plos One vol. 12, (9) e0183732-e0183732.
10.1371/journal.pone.0183732
Munroe PB and
Tinker A (2017).
Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart vol. 104, (1) 6-7.
10.1136/heartjnl-2017-311657
Zhang Y, Marrion N, Harmer S, Mohamed R,
Tinker A and Hancox J (2017).
227hERG potassium channel modulation by P127T KCNE1. Ep Europace vol. 19, (suppl_3) iii22-iii22.
10.1093/ehjci/eux138.002
Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S,
Tinker A, McKay T, Guasti L and Dunkel L (2017).
Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Molecular and Cellular Endocrinology vol. 447, 12-22.
10.1016/j.mce.2017.02.030
MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H and Cabrera CP (2017).
Discovery of novel heart rate-associated loci using the exome chip. Oxford University Press (Oup) Human Molecular Genetics 10.1093/hmg/ddx1132016

Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B, Simpson C, Klein G, Champagne J, Talajic M, Gardner M, Steinberg C, Janzen M, Arbour L, Green M, Angaran P, Roberts J, Leather R, Sanatani S, Chauhan V, Healey J, Krahn A, Taggart P, Srinivasan N, Hayward M, Lambiase PD, Aziz Q and Finlay MC (2016).
YOUNG INVESTIGATORS COMPETITION1GENETIC ANALYSIS IN THE EVALUATION OF UNEXPLAINED CARDIAC ARREST: FROM THE CARDIAC ARREST SURVIVORS WITH PRESERVED EJECTION FRACTION REGISTRY (CASPER)2IN-VIVO WHOLE HEART CONTACT MAPPING DATA AND A SIMPLE MATHEMATICAL FRAMEWORK TO UNDERSTAND THE INTERACTIONS BETWEEN ACTIVATION AND REPOLARIZATION RESITUTION DYNAMICS IN THE INTACT HUMAN HEART3THE K(ATP) CHANNEL OPENER DIAZOXIDE REDUCES AUTOMATICITY IN AN IN VITRO ATRIAL CELL MODEL - POTENTIAL FOR K(ATP) CHANNELS AS A DRUG TARGE. Ep Europace vol. 18, (suppl 2) ii1-ii3.
10.1093/europace/euw275
Champney F, Maddock LJ, Welford J, Kemp J, Allan V, Persidskikh Y, Orini M, Ang R, Workman AJ, Wong L, Honarbakhsh S, Leong KMW, Silberbauer J, O'Nunain S, Gomes J, McCready J, Bostock J, Shaw K, McKenna C, Bailey J, Casas JP, Wallace J, Hunter R, Schilling R, Perel P, Morley K, Banerjee A, Hemingway H and Mrochak A (2016).
ORAL ABSTRACTS (1). Ep Europace vol. 18, (suppl_2) ii4-ii7.
10.1093/europace/euw270
MUNROE PB (2016).
Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Publishing Group Nature Genetics 10.1038/ng.3654
Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P,
Tinker A, Valentin JP and Varro A (2016).
Human-based approaches to pharmacology and cardiology: An interdisciplinary and intersectorial workshop. Europace vol. 18, (9) 1287-1298.
10.1093/europace/euv320
Ang R, Abramowitz J, Birnbaumer L, Gourine AV and
Tinker A (2016).
The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. Physiological Reports vol. 4, (15)
10.14814/phy2.12860
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L,
Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K (2016).
GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep vol. 16, (4) 1026-1038.
10.1016/j.celrep.2016.06.050
Zhou X, Harmer S, Bueno-Orovio A, Burrage K,
Tinker A and Rodriguez B (2016).
57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation? Ep Europace vol. 18, (suppl_1) i167-i167.
10.1093/europace/18.suppl_1.i167
Tinker A, Finlay M, Nobles M and Opel A (2016).
The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation. Pharmacological Research vol. 105, 54-61.
10.1016/j.phrs.2015.11.008
Harmer SC and
Tinker A (2016).
The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes. De Gruyter Biol Chem vol. 397, (7) 679-693.
10.1515/hsz-2015-0306
Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V,
Tinker A and Baker JR (2016).
Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines. Organic and Biomolecular Chemistry vol. 14, (2) 455-459.
10.1039/c5ob02120k2015

Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S,
Tinker A, Marina N and Gourine AV (2015).
Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Heart Rhythm vol. 12, (11) 2285-2293.
10.1016/j.hrthm.2015.06.005
Fletcher SA, Sin PKB, Nobles M, Årstad E,
Tinker A and Baker JR (2015).
A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging. Organic and Biomolecular Chemistry vol. 13, (37) 9559-9563.
10.1039/c5ob01468a
Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R and
Tinker A (2015).
Absence of the regulator of G-protein Signaling, RGS4, predisposes to atrial fibrillation and is associated with abnormal calcium handling. Journal of Biological Chemistry vol. 290, (31) 19233-19244.
10.1074/jbc.M115.666719
Nessa A, Aziz QH, Thomas AM, Harmer SC,
Tinker A and Hussain K (2015).
Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8. Human Molecular Genetics vol. 24, (18) 5142-5153.
10.1093/hmg/ddv233
Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A,
Tinker A, Clarke K, Watkins H, Ferguson DJP,
Kelsell DP, De Noronha S, Sheppard MN, Hollinshead M, Mohun TJ and Lu X (2015).
iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proceedings of The National Academy of Sciences of The United States of America vol. 112, (9) E973-E981.
10.1073/pnas.14081111122014

Lane JD, Abramowitz J, Birnbaumer L and
Tinker A (2014).
51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure. Europace vol. 16 Suppl 3,
10.1093/europace/euu241.1
Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L and
Tinker A (2014).
The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control. Hypertension vol. 64, (3) 523-529.
10.1161/HYPERTENSIONAHA.114.03116
Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD and
Tinker A (2014).
Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1. Biochem J vol. 462, (1) 133-142.
10.1042/BJ20140425
Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S,
Tinker A and Baker JR (2014).
Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. Organic & Biomolecular Chemistry vol. 12, (4) 557-560.
10.1039/c3ob42141d
Tinker A, Aziz Q and Thomas A (2014).
The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system. Br J Pharmacol vol. 171, (1) 12-23.
10.1111/bph.12407
Arya VB, Aziz Q, Nessa A,
Tinker A and Hussain K (2014).
Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy. Int J Pediatr Endocrinol vol. 2014, (1)
10.1186/1687-9856-2014-242013
Tinker A and Harmer SC (2013).
Potassium channels regulating the electrical activity of the heart. Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment 10.1007/978-0-85729-920-8_6
Posokhova E, Ng D, Opel A, Masuho I,
Tinker A, Biesecker LG, Wickman K and Martemyanov KA (2013).
Essential Role of the m(2)R-RGS6-I-KACh Pathway in Controlling Intrinsic Heart Rate Variability. Plos One vol. 8, (10)
10.1371/journal.pone.0076973
Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L and
Tinker A (2013).
The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins. Am J Physiol Regul Integr Comp Physiol vol. 305, (4) R435-R442.
10.1152/ajpregu.00037.2013
Ang R, Birnbaumer L, Gourine AV and
Tinker A (2013).
The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart. European Heart Journal vol. 34, (suppl_1) p5030-p5030.
10.1093/eurheartj/eht310.p5030
Telezhkin V, Thomas AM, Harmer SC,
Tinker A and Brown DA (2013).
A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P-2. Pflugers Archiv-European Journal of Physiology vol. 465, (7) 945-953.
10.1007/s00424-012-1199-3
Schwarzer S, Mashanov GI, Molloy JE and
Tinker A (2013).
Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly. Methods Mol Biol vol. 998, 201-208.
10.1007/978-1-62703-351-0_152012

Maden CH, Gomes J, Schwarz Q, Davidson K,
Tinker A and Ruhrberg C (2012).
NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Developmental Biology vol. 369, (2) 277-285.
10.1016/j.ydbio.2012.06.026
Tinker A and Harmer SC (2012).
Potassium channels regulating the electrical activity of the heart. Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment 10.1007/978-0-85729-920-8_6
Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H, Davidson S, Zuberi Z,
Tinker A, Shui B, Tallini YI, Kotlikoff MI, Miquerol L, Schwartz RJ and Riley PR (2012).
Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Circ Res vol. 111, (2) e19-e31.
10.1161/CIRCRESAHA.111.260695
Harmer SC, Mohal JS, Kemp D and
Tinker A (2012).
Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel. Biochem J vol. 443, (3) 635-642.
10.1042/BJ20111912
Telezhkin V, Reilly JM, Thomas AM,
Tinker A and Brown DA (2012).
Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding. Journal of Biological Chemistry vol. 287, (13) 10001-10012.
10.1074/jbc.M111.322552
Aziz Q, Thomas AM, Khambra T and
Tinker A (2012).
Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C. J Biol Chem vol. 287, (9) 6196-6207.
10.1074/jbc.M111.243923
Ang R, Opel A and
Tinker A (2012).
The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias. Front Physiol vol. 3,
10.3389/fphys.2012.00096
Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ,
TINKER A and Lambiase PD (2012).
Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Oxford University Press Eur Heart Journal vol. 33, (15) 1942-1953.
10.1093/eurheartj/ehr4722011

Hothersall JD, Black J, Caddick S, Vinter JG,
Tinker A and Baker JR (2011).
The design, synthesis and pharmacological characterization of novel β 2-adrenoceptor antagonists. British Journal of Pharmacology vol. 164, (2) 317-331.
10.1111/j.1476-5381.2011.01269.x
Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN, Ghionzoli M, Cheung KK, Cabrelle A, O'Mahoney PR, Cozzi E, Sartore S,
Tinker A, Lythgoe MF and de Coppi P (2011).
In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells. Stem Cell Reviews and Reports vol. 7, (2) 364-380.
10.1007/s12015-010-9200-z
Schumacher FF, Nobles M, Ryan CP, Smith MEB,
Tinker A, Caddick S and Baker JR (2011).
In situ maleimide bridging of disulfides and a new approach to protein PEGylation. Bioconjugate Chemistry vol. 22, (2) 132-136.
10.1021/bc1004685
Voitychuk OI, Strutynskyi RB, Yagupolskii LM,
Tinker A, Moibenko OO and Shuba YM (2011).
Sarcolemmal cardiac K ATP channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin. British Journal of Pharmacology vol. 162, (3) 701-711.
10.1111/j.1476-5381.2010.01072.x
Thomas AM, Harmer SC, Khambra T and
Tinker A (2011).
Characterization of a binding site for anionic phospholipids on KCNQ1. Journal of Biological Chemistry vol. 286, 2088-2100.
10.1074/jbc.M110.153551
Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP,
Tinker A, Ellard S and Hussain K (2011).
Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations. Diab Tologia vol. 54, 2575-2583.
10.1007/s00125-011-2207-42010

Ahluwalia J,
Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M and Segal AW (2010).
Erratum: The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Nature (2004) 427 (853-858)). Nature vol. 468, (7320)
10.1038/nature09562
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A,
Tinker A and Caddick S (2010).
ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent β‐Blocker ICI‐118,551 Allows the Determination of Enantiomer Dependency on Biological Activity. Cheminform vol. 41, (43) no-no.
10.1002/chin.201043086
Schwarzer S, Nobles M and
Tinker A (2010).
Do caveolae have a role in the fidelity and dynamics of receptor activation of G-protein-gated inwardly rectifying potassium channels? Journal of Biological Chemistry vol. 285, (36) 27817-27826.
10.1074/jbc.M110.103598
Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L and
Tinker A (2010).
Absence of the inhibitory g-protein gαi2 predisposes to ventricular cardiac arrhythmia. Circulation: Arrhythmia and Electrophysiology vol. 3, (4) 391-400.
10.1161/CIRCEP.109.894329
Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A,
Tinker A and Caddick S (2010).
An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. Chemical Communications vol. 46, (22) 3953-3954.
10.1039/c0cc00142b
Nobles M, Sebastian S and
Tinker A (2010).
HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes. Pflugers Archiv European Journal of Physiology vol. 460, (1) 99-108.
10.1007/s00424-010-0799-z
Aziz Q, Thomas A, Khambra T and
Tinker A (2010).
Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel. European Journal of Pharmacology vol. 634, (1-3) 26-32.
10.1016/j.ejphar.2010.02.023
Ng KE, Schwarzer S, Duchen MR and
Tinker A (2010).
The intracellular localization and function of the ATP-sensitive K + channel subunit Kir6.1. Journal of Membrane Biology vol. 234, (2) 137-147.
10.1007/s00232-010-9241-x
Mashanov GI, Nobles M, Harmer SC, Molloy JE and
Tinker A (2010).
Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior. Journal of Biological Chemistry vol. 285, 3664-3675.
10.1074/jbc.M109.039974
Tinker A and Harmer SC (2010).
K+ channels in the heart: new insights and therapeutic implications. Expert Rev Clin Pharmacol vol. 3, 305-319.
10.1586/ecp.10.14
Harmer SC, Wilson AJ, Aldridge R and
Tinker A (2010).
Mechanisms of disease pathogenesis in long QT syndrome type 5. Am J Physiol Cell Physiol vol. 298, C263-C273.
10.1152/ajpcell.00308.20092009

Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJR,
Tinker A and Mohun TJ (2009).
Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice. Journal of Molecular and Cellular Cardiology vol. 47, (1) 133-141.
10.1016/j.yjmcc.2009.04.007
Orie NN, Thomas AM, Perrino BA,
Tinker A and Clapp LH (2009).
Ca 2+/calcineurin regulation of cloned vascular K ATP channels: Crosstalk with the protein kinase a pathway. British Journal of Pharmacology vol. 157, (4) 554-564.
10.1111/j.1476-5381.2009.00221.x2008

Zuberi Z, Birnbaumer L and
Tinker A (2008).
The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics. American Journal of Physiology - Regulatory Integrative and Comparative Physiology vol. 295, (6)
10.1152/ajpregu.90625.2008
Farzaneh T and
Tinker A (2008).
Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits. Cardiovascular Research vol. 79, (4) 621-631.
10.1093/cvr/cvn138
Campanella M, Tan C, Abramov A,
Tinker A and Duchen M (2008).
S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1. Biochimica Et Biophysica Acta (Bba) - Bioenergetics vol. 1777,
10.1016/j.bbabio.2008.05.299
Breckenridge RA, Zuberi Z, Felkin L, Birks E, Barton P,
Tinker A and Mohun T (2008).
446 Overexpression of the transcription factor Hand1 causes sudden cardiac death in mice. European Journal of Heart Failure Supplements vol. 7, 109-109.
10.1016/s1567-4215(08)60301-x
Quinn KV, Behe P and
Tinker A (2008).
Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby. Journal of Physiology vol. 586, (12) 2855-2871.
10.1113/jphysiol.2008.153791
Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AR,
TINKER A and Duchen MR (2008).
Regulation of mitochondrial structure and function by IF1, the endogenous inhibitor of the mitochondrial ATPase. Cell Metabolism vol. 8, (1) 13-25.
10.1016/j.cmet.2008.06.001
Thomas AM and
Tinker A (2008).
Determination of phosphoinositide binding to K+ channel subunits using a protein-lipid overlay assay. Methods in Molecular Biology vol. 491, 103-111.
10.1007/978-1-59745-526-8_82007

Hughes S, Marsh SJ,
Tinker A and Brown DA (2007).
PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: Direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons. Pflugers Archiv European Journal of Physiology vol. 455, (1) 115-124.
10.1007/s00424-007-0259-6
Falcetti E, Flavell DM, Staels B,
Tinker A, Haworth SG and Clapp LH (2007).
IP receptor-dependent activation of PPARγ by stable prostacyclin analogues. Biochemical and Biophysical Research Communications vol. 360, (4) 821-827.
10.1016/j.bbrc.2007.06.135
Harmer SC and
Tinker A (2007).
The role of abnormal trafficking of KCNE1 in long QT syndrome 5. Biochemical Society Transactions vol. 35, 1074-1076.
10.1042/BST0351074
Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K and
Tinker A (2007).
Complex ABCC8 DNA variations in congenital hyperinsulinism: Lessons from functional studies. Clinical Endocrinology vol. 67, (1) 115-124.
10.1111/j.1365-2265.2007.02847.x2006

Tennant BP, Cui Y,
Tinker A and Clapp LH (2006).
Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: Evidence for a major role of Kir2.4 subunits. Journal of Membrane Biology vol. 213, (1) 19-29.
10.1007/s00232-006-0037-y
Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI,
Tinker A, Tsushima RG and Gaisano HY (2006).
Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac KATP channel activation. Journal of Biological Chemistry vol. 281, (28) 19019-19028.
10.1074/jbc.M513160200
Thomas AM, Brown SG, Leaney JL and
Tinker A (2006).
Differential phosphoinositide binding to components of the G protein-gated K+ channel. Journal of Membrane Biology vol. 211, (1) 43-53.
10.1007/s00232-006-0014-5
Tinker A (2006).
The selective interactions and functions of regulators of G-protein signalling. Seminars in Cell and Developmental Biology vol. 17, (3) 377-382.
10.1016/j.semcdb.2006.03.0072005

Nobles M, Benians A and
Tinker A (2005).
Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proceedings of The National Academy of Sciences of The United States of America vol. 102, (51) 18706-18711.
10.1073/pnas.0504778102
Brown SG, Thomas A, Dekker LV,
Tinker A and Leaney JL (2005).
PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells. American Journal of Physiology - Cell Physiology vol. 289, (3 58-3)
10.1152/ajpcell.00025.2005
Wilson AJ, Quinn KV, Graves FM, Bitner-Glindzicz M and
Tinker A (2005).
Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1). Cardiovascular Research vol. 67, (3) 476-486.
10.1016/j.cardiores.2005.04.036
Benians A, Nobles M, Hosny S and
Tinker A (2005).
Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein: A novel explanation for the acceleration of signaling activation kinetics. Journal of Biological Chemistry vol. 280, (14) 13383-13394.
10.1074/jbc.M410163200
Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong XY, Yoshida H, Nakamura TY, Artman M, Giblin JP,
Tinker A and Coetzee WA (2005).
Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Bmc Physiology vol. 5,
10.1186/1472-6793-5-12004

Leaney JL, Benians A, Brown S, Nobles M, Kelly D and
Tinker A (2004).
Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle. American Journal of Physiology - Cell Physiology vol. 287, (1 56-1)
10.1152/ajpcell.00540.2003
Quinn KV, Giblin JP and
Tinker A (2004).
Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K+ channel. Circulation Research vol. 94, (10) 1359-1366.
10.1161/01.RES.0000128513.34817.c4
Ahluwalia J,
Tinker A, Clapp LH, Buchen MR, Abramov AY, Pope S, Nobles M and Segal AW (2004).
The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature vol. 427, (6977) 853-858.
10.1038/nature023562003

Quinn KV, Cui Y, Giblin JP, Clapp LH and
Tinker A (2003).
Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? Circulation Research vol. 93, (7) 646-655.
10.1161/01.RES.0000095247.81449.8E
Benians A, Leaney JL and
Tinker A (2003).
Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels. Proceedings of The National Academy of Sciences of The United States of America vol. 100, (10) 6239-6244.
10.1073/pnas.1037595100
Cui Y,
Tinker A and Clapp LH (2003).
Different molecular sites of action for the K ATP channel inhibitors, PNU-99963 and PNU-37883A. British Journal of Pharmacology vol. 139, (1) 122-128.
10.1038/sj.bjp.0705228
Benians A, Leaney JL, Milligan G and
Tinker A (2003).
The dynamics of formation and action of the ternary complex revealed in living cells using a G-protein-gated K+ channel as a biosensor. Journal of Biological Chemistry vol. 278, (12) 10851-10858.
10.1074/jbc.M2122992002002

Giblin JP, Quinn K and
Tinker A (2002).
The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking. European Journal of Biochemistry vol. 269, (21) 5303-5313.
10.1046/j.1432-1033.2002.03249.x
Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R,
Tinker A, Stephanou A, Knight RA and Latchman DS (2002).
KATP channel gene expression is induced by urocortin and mediates its cardioprotective effect. Circulation vol. 106, (12) 1556-1562.
10.1161/01.CIR.0000028424.02525.AE
Giblin JP, Cui Y, Clapp LH and
Tinker A (2002).
Assembly limits the pharmacological complexity of ATP-sensitive potassium channels. Journal of Biological Chemistry vol. 277, (16) 13717-13723.
10.1074/jbc.M112209200
Cui Y, Tran S,
Tinker A and Clapp LH (2002).
The molecular composition of KATP channels in human pulmonary artery smooth muscle cells and their modulation by growth. American Journal of Respiratory Cell and Molecular Biology vol. 26, (1) 135-143.
10.1165/ajrcmb.26.1.4622
Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ and
Tinker A (2002).
Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. American Journal of Respiratory Cell and Molecular Biology vol. 26, (2) 194-201.
10.1165/ajrcmb.26.2.4695
Leaney JL, Benians A, Graves FM and
Tinker A (2002).
A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits. The Journal of Biological Chemistry vol. 277, (32) 28803-28809.
10.1074/jbc.M2046832002001

Leaney JL, Dekker LV and
Tinker A (2001).
Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca2+ -independent protein kinase C. Journal of Physiology vol. 534, (2) 367-379.
10.1111/j.1469-7793.2001.00367.x
Cui Y, Giblin JP, Clapp LH and
Tinker A (2001).
A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits. Proceedings of The National Academy of Sciences of The United States of America vol. 98, (2) 729-734.
10.1073/pnas.98.2.729
Huang L, Bitner-Glindzicz M, Tranebjærg L and
Tinker A (2001).
A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome. Cardiovascular Research vol. 51, (4) 670-680.
10.1016/S0008-6363(01)00350-92000

Graves FM and
Tinker A (2000).
Functional expression of the pore forming subunit of the ATP-sensitive potassium channel in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications vol. 272, (2) 403-409.
10.1006/bbrc.2000.2798
Leaney JL and
Tinker A (2000).
The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proceedings of The National Academy of Sciences of The United States of America vol. 97, (10) 5651-5656.
10.1073/pnas.080572297
Leaney JL, Milligan G and
Tinker A (2000).
The G protein α subunit has a key role in determining the specificity of coupling to, but not the activation of, G protein-gated inwardly rectifying K+ channels. Journal of Biological Chemistry vol. 275, (2) 921-929.
10.1074/jbc.275.2.9211999
Tinker A and Jan LY (1999).
Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels. Current Topics in Membranes and Transport vol. 46, (C) 143-158.
10.1016/S0070-2161(08)60925-9
Giblin JP, Leaney JL and
Tinker A (1999).
The molecular assembly of ATP-sensitive potassium channels. Determinants on the pore forming subunit. Journal of Biological Chemistry vol. 274, (32) 22652-22659.
10.1074/jbc.274.32.226521998
1997

Welch W, Williams AJ,
Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR, Besch HR, Airey JA, Sutko JL and Ruest L (1997).
Structural components of ryanodine responsible for modulation of sarcoplasmic reticulum calcium channel function. Biochemistry vol. 36, (10) 2939-2950.
10.1021/bi96239011996
Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR, Besch HR and Williams AJ (1996).
Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel. Biophysical Journal vol. 70, (5) 2110-2119.
10.1016/S0006-3495(96)79777-11995
Tinker A and Williams AJ (1995).
Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers. Biophysical Journal vol. 68, (1) 111-120.
10.1016/S0006-3495(95)80165-71994

Lindsay ARG,
Tinker A and Willams AJ (1994).
How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca2+-release channel? Journal of General Physiology vol. 104, (3) 425-447.
10.1085/jgp.104.3.4251993
Tinker A and Williams AJ (1993).
Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations. Journal of General Physiology vol. 102, (6) 1107-1129.
10.1085/jgp.102.6.1107
Tinker A and Williams AJ (1993).
Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel. Biophysical Journal vol. 65, (4) 1678-1683.
10.1016/S0006-3495(93)81201-3
Tinker A, Lindsay ARG and Williams AJ (1993).
Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions. Cardiovascular Research vol. 27, (10) 1820-1825.
10.1093/cvr/27.10.1820
Tinker A and Williams AJ (1993).
Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel. Biophysical Journal vol. 65, (2) 852-864.
10.1016/S0006-3495(93)81104-41992
Tinker A and Williams AJ (1992).
Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. Journal of General Physiology vol. 100, (3) 479-493.
10.1085/jgp.100.3.479
Tinker A, Lindsay ARG and Williams AJ (1992).
Block of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by tetra-alkyl ammonium cations. The Journal of Membrane Biology vol. 127, (2) 149-159.
10.1007/BF00233287
Tinker A, Lindsay AR and Williams AJ (1992).
Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel. Biophysical Journal vol. 61, (5) 1122-1132.
10.1016/S0006-3495(92)81922-7
Tinker A, Lindsay ARG and Williams AJ (1992).
A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. Journal of General Physiology vol. 100, (3) 495-517.
10.1085/jgp.100.3.495