Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A, Ackland GL and Gourine AV (2023). Transcriptional response of the heart to vagus nerve stimulation. Physiol Genomics  10.1152/physiolgenomics.00095.2023

Ramirez J, Martinez JP, Van Duijvenboden S, Tinker A, Lambiase P, Orini M, Munroe PB and Miguel A (2023). Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population. Oxford University Press (Oup)  European Heart Journal  vol. 44, (Supplement_2) 10.1093/eurheartj/ehad655.2914

Orini M, Van Duijvenboden S, Young WJ, Ramirez J, Jones AR, Tinker A, Munroe PB and Lambiase PD (2023). Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease. Oxford University Press (Oup)  European Heart Journal  vol. 44, (Supplement_2) 10.1093/eurheartj/ehad655.2912

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Hughes AD, Tinker A, Munroe PB and Lambiase PD (2023). Long-term association of ultra-short heart rate variability with cardiovascular events. Springer Nature  Scientific Reports  vol. 13, (1) 10.1038/s41598-023-45988-2

Sanpawithayakul K, Mistry A, Rai A, Funge G, Sebastian S, Solomou A, Lillina VM, Gaston-Massuet C, Tinker A, Begalli F and Korbonits M (2023). Hindering the progression of cardiac fibrosis in acromegaly - the role of somatostatin receptor ligands. Bioscientifica  Endocrine Abstracts  10.1530/endoabs.94.p363

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K (2023). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Elsevier  Cell Reports  vol. 42, (11) 10.1016/j.celrep.2023.113383

van Duijvenboden S, Ramírez J, Orini M, Aung N, Petersen SE, Doherty A, Tinker A, Munroe PB and Lambiase PD (2023). Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects. Wolters Kluwer  Circulation  vol. 148, (24) 1932-1944. 10.1161/circulationaha.123.064633

Specterman MJ, Aziz Q, Li Y, Anderson NA, Ojake L, Ng K-E, Thomas AM, Finlay MC, Schilling RJ, Lambiase PD and Tinker A (2023). Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels. Wolters Kluwer  Circulation Arrhythmia and Electrophysiology  vol. 16, (9) 10.1161/circep.123.011870

Korsak A, Kellett DO, Aziz Q, Anderson C, D’Souza A, Tinker A, Ackland GL and Gourine AV (2023). Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training. Oxford University Press (Oup)  Cardiovascular Research  vol. 119, (13) 2329-2341. 10.1093/cvr/cvad115

Zawada D, Kornherr J, Meier AB, Santamaria G, Dorn T, Nowak-Imialek M, Ortmann D, Zhang F, Lachmann M, Dreßen M, Ortiz M, Mascetti VL, Harmer SC, Nobles M, Tinker A, De Angelis MT, Pedersen RA, Grote P, Laugwitz K-L, Moretti A and Goedel A (2023). Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools. Springer Nature  Nature Communications  vol. 14, (1) 10.1038/s41467-023-36764-x

Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A, Harper AR, Ramirez J, Garnier S, van Duijvenboden S, Baldassari AR, Concas MP, Duong T, Foco L, Isaksen JL, Mei H, Noordam R, Nursyifa C, Richmond A, Santolalla ML, Sitlani CM, Soroush N, Thériault S, Trompet S, Aeschbacher S, Ahmadizar F, Alonso A, Brody JA, Campbell A and Correa A (2023). Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Springer Nature  Nature Communications  vol. 14, (1) 10.1038/s41467-023-36997-w

Orini M, van Duijvenboden S, Young WJ, Ramírez J, Jones AR, Tinker A, Munroe PB and Lambiase PD (2023). Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events. Oxford University Press (Oup)  European Heart Journal - Digital Health  vol. 4, (2) 112-118. 10.1093/ehjdh/ztad007

Bercea C, Limbu R, Behnam K, Ng K-E, Aziz Q, Tinker A, Tamagnini F, Cottrell GS and McNeish AJ (2022). Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels. Frontiers  Frontiers in Physiology  vol. 13, 10.3389/fphys.2022.1033216

Kwek X-Y, Hall AR, Lim W-W, Katwadi K, Soong PL, Grishina E, Lin K-H, Crespo-Avilan G, Yap EP, Ismail NI, Chinda K, Chung YY, Wei H, Shim W, Montaigne D, Tinker A, Ong S-B and Hausenloy DJ (2022). Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion. Springer Nature  Scientific Reports  vol. 12, (1) 10.1038/s41598-022-25625-0

Wilson D, Tinker A and Iskratsch T (2022). Investigating cardiomyocyte dysfunction in dilated cardiomyopathy associated with Duchenne muscular dystrophy. Elsevier  Journal of Molecular and Cellular Cardiology  vol. 173, 10.1016/j.yjmcc.2022.08.038

Sebastian S, Weinstein LS, Ludwig A, Munroe P and Tinker A (2022). Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy. Oxford University Press (Oup)  Function  vol. 4, (1) 10.1093/function/zqac055

Iskratsch T, Wilson D and Tinker A (2022). The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction. Nature Research  Communications Biology  10.1038/s42003-022-03980-y

Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody JA, Salman R, Noordam R, Benjamins J-W, Haessler J, Lyytikäinen L-P, Repetto L, Concas MP, van den Berg ME, Weiss S, Baldassari AR, Bartz TM, Cook JP, Evans DS, Freudling R, Hines O, Isaksen JL, Lin H, Mei H, Moscati A, Müller-Nurasyid M, Nursyifa C, Qian Y and Richmond A (2022). Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Springer Nature  Nature Communications  vol. 13, (1) 10.1038/s41467-022-32821-z

Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV, Orini M and Munroe PB (2022). ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations. Wolters Kluwer  Journal of The American Heart Association  vol. 11, (17) 10.1161/jaha.121.025897

Williams JL, Paudyal A, Stewart M, Cutillas P, Tinker A and Metherell L (2022). Abstract P2005: Loss Of Full-length Mylk3 Causes Dilated Cardiomyopathy Via A MYL2-independent Mechanism. Wolters Kluwer  Circulation Research  vol. 131, (Suppl_1) ap2005-ap2005. 10.1161/res.131.suppl_1.p2005

Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M and Munroe P (2022). Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors. Elsevier  Atherosclerosis  vol. 355, 3-4. 10.1016/j.atherosclerosis.2022.06.012

Ramírez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M and Munroe PB (2022). Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors. Circulation Genomic and Precision Medicine  vol. 15, (5) e003441-e003441. 10.1161/circgen.121.003441

Christensen SL, Rasmussen RH, La Cour S, Ernstsen C, Hansen TF, Kogelman LJ, Lauritzen SP, Guzaite G, Styrishave B, Janfelt C, Christensen ST, Aziz Q, Tinker A, Jansen-Olesen I, Olesen J and Kristensen DM (2021). Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models. Sage Publications  Cephalalgia  vol. 42, (2) 93-107. 10.1177/03331024211053570

Williams J, paudyal A, Stewart M, Cutillas P, Cox RD, Tinker A and Metherell L (2021). Abstract 14037: A Shorter Myosin Light Chain Kinase 3 Isoform Maintains Myosin Light Chain 2 Phosphorylation but Does Not Attenuate the Dilated Cardiomyopathy Seen in C57BL/6N Mice. Wolters Kluwer  Circulation  vol. 144, (Suppl_1) a14037-a14037. 10.1161/circ.144.suppl_1.14037

Tinker A (2021). Does knowledge of the mutation in hereditary long QT syndrome aid risk stratification? Oxford University Press (Oup)  European Heart Journal  vol. 42, (46) 10.1093/eurheartj/ehab668

Rathod VSHS, Harmer S, Royal A, Aziz Q, Lambiase P and Tinker A (2021). B-PO02-015 ENHANCING MUTANT I KSCHANNEL ACTIVITY BY ALTERING ENDOGENOUS PIP2 LEVELS AND ITS INTERACTION WITH PKA SIGNALLING PATHWAY. Elsevier  Heart Rhythm  vol. 18, (8) 10.1016/j.hrthm.2021.06.272

Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD and Munroe PB (2021). Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders. Oxford University Press (Oup)  Human Molecular Genetics  vol. 30, (24) 10.1093/hmg/ddab197

Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G, Walker SLM, Westaby JD, Pennington DJ, Pink R, Kelsell DP and Tinker A (2021). Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy. Springer Nature  Cell and Tissue Research  vol. 386, (1) 79-98. 10.1007/s00441-021-03488-7

Rathod V, Harmer S, Royal A, Aziz Q, Lambiase P and Tinker A (2021). Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway. Oxford University Press (Oup)  Ep Europace  vol. 23, (Supplement_3) 10.1093/europace/euab116.543

Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D, Lambiase PD, Jukema JW, Munroe PB and Noordam R (2021). Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization. Wolters Kluwer  Circulation Genomic and Precision Medicine  vol. 14, (3) 10.1161/circgen.120.003231

Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB and Tinker A (2021). The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate. American Physiological Society  Physiological Genomics  vol. 53, (4) 150-159. 10.1152/physiolgenomics.00157.2020

Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD, Tinker A, Marouli E, Munroe PB and Ramírez J (2021). No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis. Frontiers  Frontiers in Genetics  vol. 12, 10.3389/fgene.2021.569323

Li Y, Aziz Q and Tinker A (2021). The Pharmacology of ATP-Sensitive K+ Channels (KATP). Springer Nature  10.1007/164_2021_466

Tinker A, Aziz Q and Li Y (2021). ATP-Dependent K+ Channels. Encyclopedia of Molecular Pharmacology  Springer Nature  10.1007/978-3-030-57401-7_24

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB and Tinker A (2021). Analysing electrocardiographic traits and predicting cardiac risk in UK biobank. Sage Publications  Jrsm Cardiovascular Disease  vol. 10, 10.1177/20480040211023664

Ramírez J and Tinker A (2020). Ventricular Restitution Predicts Paroxysmal Atrial Fibrillation in Horses. Oxford University Press (Oup)  Function  vol. 2, (1) 10.1093/function/zqaa038

Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD and Orini M (2020). A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs. Elsevier  Biomedical Signal Processing and Control  vol. 64, 10.1016/j.bspc.2020.102305

Balestrini S, Mikati MA, Garcia-Roves RA, Carboni M, Hunanyan AS, Kherallah B, McLean M, Prange L, De Grandis E, Gagliardi A, Pisciotta L, Stagnaro M, Veneselli E, Campistol J, Fons C, Pias-Peleteiro L, Brashear A, Miller C, Samoes R, Brankovic V, Padiath QS, Potic A, Pilch J, Vezyroglou K, Bye AME, Davis AM, Ryan MM, Semsarian C, Hollingsworth G and Scheffer IE (2020). Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study. American Academy of Neurology  Neurology  10.1212/WNL.0000000000010794

Li Y, Aziz Q, Anderson N, Ojake L and Tinker A (2020). Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis. American Heart Association  Hypertension  HYPERTENSIO-HYPERTENSIO. 10.1161/HYPERTENSIONAHA.120.15355

Aziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Springer Science and Business Media Llc  Journal of Molecular Medicine  10.1007/s00109-020-01946-3

Villar D, Frost S, Deloukas P and Tinker A (2020). The contribution of non-coding regulatory elements to cardiovascular disease. The Royal Society  Open Biology  vol. 10, (7) 200088-200088. 10.1098/rsob.200088

Aziz Q and Tinker A (2020). The Pathophysiology of Cardiac Abnormalities in Cantu Syndrome: Perspective on The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. Oup  Function  vol. 1, (1) zqaa005-zqaa005. 10.1093/function/zqaa005

van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB and Lambiase PD (2020). Genetic Basis and Prognostic Value of Exercise QT Dynamics. Wolters Kluwer  Circulation Genomic and Precision Medicine  vol. 13, (4) e002774-e002774. 10.1161/circgen.119.002774

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A and Morris AP (2020). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Springer Nature  Nature Communications  vol. 11, (1) 10.1038/s41467-020-15706-x

Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB and Tinker A (2020). Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. Elsevier  American Journal of Human Genetics  vol. 106, (6) 764-778. 10.1016/j.ajhg.2020.04.009

Williams JL, Paudyal A, Awad S, Nicholson J, Grzesik D, Botta J, Meimaridou E, Maharaj AV, Stewart M, Tinker A, Cox RD and Metherell LA (2020). Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not. Life Science Alliance, Llc  Life Science Alliance  vol. 3, (4) 10.26508/lsa.201900593

Aziz Q, Nobles M and Tinker A (2020). Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells. Bio-Protocol, Llc  Bio-Protocol  vol. 10, (1) 10.21769/bioprotoc.3478

Aziz Q, Nobles M and Tinker A (2020). Acute Isolation of Cells from Murine Sino-atrial Node. Bio-Protocol, Llc  Bio-Protocol  vol. 10, (1) 10.21769/bioprotoc.3477

Tinker A, Aziz Q and Li Y (2020). ATP-Dependent K + Channels. Encyclopedia of Molecular Pharmacology  Springer Nature  10.1007/978-3-030-21573-6_24-1

Ramírez J, van Duijvenboden S, Aung N, Laguna P, Pueyo E, Tinker A, Lambiase PD, Orini M and Munroe PB (2019). Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics. American Heart Association  Circulation: Arrhythmia and Electrophysiology  vol. 12, (10) e007549-e007549. 10.1161/CIRCEP.119.007549

Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A and Munroe PB (2019). Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function. Oxford University Press (Oup)  Human Molecular Genetics  vol. 29, (11) 1797-1807. 10.1093/hmg/ddz198

Thomas AM, Cabrera CP, Finlay M, Lall K, Nobles M, Schilling RJ, Wood K, Mein CA, Barnes MR, Munroe PB and Tinker A (2019). Differentially expressed genes for atrial fibrillation identified by RNA sequencing from paired human left and right atrial appendages. Physiol Genomics  vol. 51, (8) 323-332. 10.1152/physiolgenomics.00012.2019

Finlay M, Bhar-Amato J, Ng K-E, Santos D, Orini M, Vyas V, Taggart P, Grace AA, Huang CL-H, Lambiase PD and Tinker A (2019). Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome. Am J Physiol Cell Physiol  10.1152/ajpcell.00028.2019

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen L-P, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA, Shah N, Schramm K, Vidigal PG, Weiss S and Yao J (2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. Elsevier  Journal of The American College of Cardiology  vol. 73, (24) 3118-3131. 10.1016/j.jacc.2019.03.519

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP (2019). DSP 突变与致心律失常性心肌病. Oxford University Press (Oup)  British Journal of Dermatology  vol. 180, (5) e169-e169. 10.1111/bjd.17808

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP (2019). DSP mutations and arrhythmogenic cardiomyopathy. Oxford University Press (Oup)  British Journal of Dermatology  vol. 180, (5) e157-e157. 10.1111/bjd.17796

Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A, Rodriguez B and Harmer SC (2019). Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D. Front Physiol  vol. 10, 259-259. 10.3389/fphys.2019.00259

Honarbakhsh S, Hunter RJ, Finlay M, Ullah W, Keating E, Tinker A and Schilling RJ (2019). Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method. Wiley  Journal of Cardiovascular Electrophysiology  vol. 30, (5) 691-701. 10.1111/jce.13882

Maruthappu T, Posafalvi A, Castelletti S, Delaney PJ, Syrris P, O'Toole EA, Green KJ, Elliott PM, Lambiase PD, Tinker A, McKenna WJ and Kelsell DP (2019). Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype. Oxford University Press (Oup)  British Journal of Dermatology  vol. 180, (5) 1114-1122. 10.1111/bjd.17388

Ang R, Mastitskaya S, Hosford PS, Basalay M, Specterman M, Aziz Q, Li Y, Orini M, Taggart P, Lambiase PD, Gourine A, Tinker A and Gourine AV (2018). Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1). Circ Arrhythm Electrophysiol  vol. 11, (10) e006740-e006740. 10.1161/CIRCEP.118.006740

Calmont A, Anderson N, Suntharalingham JP, Ang R, Tinker A and Scambler PJ (2018). Defective Vagal Innervation in Murine Tbx1 Mutant Hearts. Mdpi  Journal of Cardiovascular Development and Disease  vol. 5, (4) 10.3390/jcdd5040049

Tinker A, Aziz Q, Li Y and Specterman M (2018). ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles. Wiley  10.1002/cphy.c170048

Bhar-Amato J, Finlay M, Santos D, Orini M, Chaubey S, Vyas V, Taggart P, Grace AA, Huang CL-H, Ben Simon R, Tinker A and Lambiase PD (2018). Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome. Circ Arrhythm Electrophysiol  vol. 11, (9) e006330-e006330. 10.1161/CIRCEP.118.006330

Castelletti S, Maruthappu T, Posafalvi A, Syrris P, O'Toole EA, Green KJ, Tinker A, McKenna WJ and Kelsell DP (2018). P5709Hair and cutaneous phenotypes linked to Arrhythmogenic Cardiomyopathy caused by Desmoplakin haploinsufficiency: an additional disease marker. Oxford University Press (Oup)  European Heart Journal  vol. 39, (suppl_1) 10.1093/eurheartj/ehy566.p5709

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu C-T, Lyytikäinen L-P, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F and Ramirez J (2018). Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Springer Nature  Genome Biology  vol. 19, (1) 10.1186/s13059-018-1457-6

Hosford PS, Christie IN, Niranjan A, Aziz Q, Anderson N, Ang R, Lythgoe MF, Wells JA, Tinker A and Gourine AV (2018). A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow. Sage Publications  Journal of Cerebral Blood Flow and Metabolism  10.1177/0271678X18780602

Ramírez J, Duijvenboden SV, Ntalla I, Mifsud B, Warren HR, Tzanis E, Orini M, Tinker A, Lambiase PD and Munroe PB (2018). Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system. Springer Nature  Nature Communications  vol. 9, (1) 10.1038/s41467-018-04148-1

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A and Denning C (2018). CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. Oxford University Press (Oup)  European Heart Journal  vol. 39, (43) 3879-3892. 10.1093/eurheartj/ehy249

Aziz Q, Finlay M, Montaigne D, Ojake L, Li Y, Anderson N, Ludwig A and Tinker A (2018). ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia. Elsevier  Journal of Biological Chemistry  vol. 293, (23) 8912-8921. 10.1074/jbc.ra118.002775

Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A, Kelsell DP and Chikh A (2018). p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Springer Nature  Nature Communications  vol. 9, (1) 10.1038/s41467-018-03470-y

Tinker A, Finlay M, Nobles M and Opel A (2018). Erratum to “The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation” [Pharmacol. Res. 105 (2016) 54–61]. Elsevier  Pharmacological Research  vol. 129, 10.1016/j.phrs.2018.02.019

Rathod VS, Harmer SC, Salsbury GA, Bitner-Glindzicz M, Lambiase PD and Tinker A (2018). P449The novel long QT syndrome type 1 mutation KCNQ1-p.Thr247dup causes severe channel dysfunction but retains preserved adrenergic regulation. Oxford University Press (Oup)  Ep Europace  vol. 20, (suppl_1) i87-i87. 10.1093/europace/euy015.258

Lovering RC, Roncaglia P, Howe DG, Laulederkind SJF, Khodiyar VK, Berardini TZ, Tweedie S, Foulger RE, Osumi-Sutherland D, Campbell NH, Huntley RP, Talmud PJ, Blake JA, Breckenridge R, Riley PR, Lambiase PD, Elliott PM, Clapp L, Tinker A and Hill DP (2018). Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology. Circ Genom Precis Med  vol. 11, (2) e001813-e001813. 10.1161/CIRCGEN.117.001813

Nobles M, Montaigne D, Sebastian S, Birnbaumer L and Tinker A (2018). Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria. American Physiological Society  American Journal of Physiology - Cell Physiology  vol. 314, (5) c616-c626. 10.1152/ajpcell.00271.2016

Aziz Q, Li Y and Tinker A (2018). Endothelial biology and ATP-sensitive potassium channels. Taylor & Francis  Channels  vol. 12, (1) 45-46. 10.1080/19336950.2017.1412151

Aziz Q, Li Y and Tinker A (2018). Potassium channels in the sinoatrial node and their role in heart rate control. Taylor & Francis  Channels  vol. 12, (1) 356-366. 10.1080/19336950.2018.1532255

Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C, Tinker A, Harmer SC, Aziz Q, Terry A, Struebig M, Warren HR, Vadgama B, Fowler DJ, Peebles D, Taylor AM, Lally PJ and Thayyil S (2018). Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Wolters Kluwer  Circulation Genomic and Precision Medicine  vol. 11, (1) 10.1161/circgen.117.001817

Orini M, Tinker A, Munroe PB and Lambiase PD (2018). Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Plos One  vol. 13, (2) e0193039-e0193039. 10.1371/journal.pone.0193039

Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD and Tinker A (2017). Ajmaline blocks I Na and I Kr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters. Elsevier  Stem Cell Research  vol. 25, 233-244. 10.1016/j.scr.2017.11.003

TINKER A and Lane J D (2017). Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology? Frontiers Media  Frontiers in Physiology  vol. 8, 10.3389/fphys.2017.00890

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG and Tarasova YS (2017). Mammalian γ2 AMPK regulates intrinsic heart rate. Macmillan Publications  Nat Commun  vol. 8, (1) 1258-1258. 10.1038/s41467-017-01342-5

Royal AA, Tinker A and Harmer SC (2017). Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking. Public Library of Science  Plos One  vol. 12, (10) e0186293-e0186293. 10.1371/journal.pone.0186293

Lane JD, Montaigne D and Tinker A (2017). Tissue-Level Cardiac Electrophysiology Studied in Murine Myocardium Using a Microelectrode Array: Autonomic and Thermal Modulation. Springer Nature  The Journal of Membrane Biology  vol. 250, (5) 471-481. 10.1007/s00232-017-9973-y

Aziz Q, Li Y, Anderson N, Ojake L, Tsisanova E and Tinker A (2017). Molecular and functional characterization of the endothelial ATP-sensitive potassium channel. Elsevier  Journal of Biological Chemistry  vol. 292, (43) 17587-17597. 10.1074/jbc.m117.810325

Orini M, Tinker A, Munroe PB and Lambiase PD (2017). Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort. Public Library of Science  Plos One  vol. 12, (9) e0183732-e0183732. 10.1371/journal.pone.0183732

Tinker A (2017). The mechanisms of ventricular arrhythmia in Chagas disease. Elsevier  International Journal of Cardiology  vol. 240, 372-373. 10.1016/j.ijcard.2017.03.094

Munroe PB and Tinker A (2017). Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart  vol. 104, (1) 6-7. 10.1136/heartjnl-2017-311657

Zhang Y, Marrion N, Harmer S, Mohamed R, Tinker A and Hancox J (2017). 227hERG potassium channel modulation by P127T KCNE1. Oxford University Press (Oup)  Ep Europace  vol. 19, (suppl_3) iii22-iii22. 10.1093/ehjci/eux138.002

MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H and Cabrera CP (2017). Discovery of novel heart rate-associated loci using the exome chip. Oxford University Press (Oup)  Human Molecular Genetics  10.1093/hmg/ddx113

Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T, Guasti L and Dunkel L (2017). Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells. Elsevier  Molecular and Cellular Endocrinology  vol. 447, 12-22. 10.1016/j.mce.2017.02.030

Finlay M, Harmer SC and Tinker A (2017). The control of cardiac ventricular excitability by autonomic pathways. Elsevier  Pharmacology & Therapeutics  vol. 174, 97-111. 10.1016/j.pharmthera.2017.02.023

Mellor G, Orini M, Specterman MJ, Sawhney VS, Merghani A, Claridge S, Laksman Z, Gerull B, Simpson C, Klein G, Champagne J, Talajic M, Gardner M, Steinberg C, Janzen M, Arbour L, Green M, Angaran P, Roberts J, Leather R, Sanatani S, Chauhan V, Healey J, Krahn A, Taggart P, Srinivasan N, Hayward M, Lambiase PD, Aziz Q and Finlay MC (2016). YOUNG INVESTIGATORS COMPETITION1GENETIC ANALYSIS IN THE EVALUATION OF UNEXPLAINED CARDIAC ARREST: FROM THE CARDIAC ARREST SURVIVORS WITH PRESERVED EJECTION FRACTION REGISTRY (CASPER)2IN-VIVO WHOLE HEART CONTACT MAPPING DATA AND A SIMPLE MATHEMATICAL FRAMEWORK TO UNDERSTAND THE INTERACTIONS BETWEEN ACTIVATION AND REPOLARIZATION RESITUTION DYNAMICS IN THE INTACT HUMAN HEART3THE K(ATP) CHANNEL OPENER DIAZOXIDE REDUCES AUTOMATICITY IN AN IN VITRO ATRIAL CELL MODEL - POTENTIAL FOR K(ATP) CHANNELS AS A DRUG TARGE. Oxford University Press (Oup)  Ep Europace  vol. 18, (suppl 2) ii1-ii3. 10.1093/europace/euw275

Champney F, Maddock LJ, Welford J, Kemp J, Allan V, Persidskikh Y, Orini M, Ang R, Workman AJ, Wong L, Honarbakhsh S, Leong KMW, Silberbauer J, O'Nunain S, Gomes J, McCready J, Bostock J, Shaw K, McKenna C, Bailey J, Honarbakhsh S, Casas JP, Wallace J, Hunter R, Schilling R, Perel P, Morley K, Banerjee A, Hemingway H and Mrochak A (2016). ORAL ABSTRACTS (1). Oxford University Press (Oup)  Ep Europace  vol. 18, (suppl_2) ii4-ii7. 10.1093/europace/euw270

MUNROE PB (2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Publishing Group  Nature Genetics  10.1038/ng.3654

Ang R, Abramowitz J, Birnbaumer L, Gourine AV and Tinker A (2016). The role of GαO‐mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. Wiley  Physiological Reports  vol. 4, (15) 10.14814/phy2.12860

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K (2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep  vol. 16, (4) 1026-1038. 10.1016/j.celrep.2016.06.050

Zhou X, Harmer S, Bueno-Orovio A, Burrage K, Tinker A and Rodriguez B (2016). 57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation? Oxford University Press (Oup)  Ep Europace  vol. 18, (suppl_1) i167-i167. 10.1093/europace/18.suppl_1.i167

Harmer SC and Tinker A (2016). The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes. De Gruyter  Biol Chem  vol. 397, (7) 679-693. 10.1515/hsz-2015-0306

Tinker A, Finlay M, Nobles M and Opel A (2016). The contribution of pathways initiated via the Gq\11 G-protein family to atrial fibrillation. Elsevier  Pharmacological Research  vol. 105, 54-61. 10.1016/j.phrs.2015.11.008

Richards DA, Fletcher SA, Nobles M, Kossen H, Tedaldi L, Chudasama V, Tinker A and Baker JR (2016). Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines. Royal Society of Chemistry (Rsc)  Organic & Biomolecular Chemistry  vol. 14, (2) 455-459. 10.1039/c5ob02120k

Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RAB, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin J-P and Varro A (2015). Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop. Oxford University Press (Oup)  Ep Europace  vol. 18, (9) 1287-1298. 10.1093/europace/euv320

Munroe PB and Tinker A (2015). Genome-wide association studies and contribution to cardiovascular physiology. American Physiological Society  Physiological Genomics  vol. 47, (9) 365-375. 10.1152/physiolgenomics.00004.2015

Nessa A, Aziz QH, Thomas AM, Harmer SC, Tinker A and Hussain K (2015). Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8. Oxford University Press (Oup)  Human Molecular Genetics  vol. 24, (18) 5142-5153. 10.1093/hmg/ddv233

Opel A, Nobles M, Montaigne D, Finlay M, Anderson N, Breckenridge R and Tinker A (2015). Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling*. Elsevier  Journal of Biological Chemistry  vol. 290, (31) 19233-19244. 10.1074/jbc.m115.666719

Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A, Marina N and Gourine AV (2015). Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Elsevier  Heart Rhythm  vol. 12, (11) 2285-2293. 10.1016/j.hrthm.2015.06.005

Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJP, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ and Lu X (2015). iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 112, (9) e973-e981. 10.1073/pnas.1408111112

Aziz Q, Li Y and Tinker A (2015). ATP-sensitive potassium channels and vascular function. Taylor & Francis  Channels  vol. 9, (1) 3-4. 10.1080/19336950.2015.1004289

Fletcher SA, Sin PKB, Nobles M, Årstad E, Tinker A and Baker JR (2015). A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging. Royal Society of Chemistry (Rsc)  Organic & Biomolecular Chemistry  vol. 13, (37) 9559-9563. 10.1039/c5ob01468a

Arya VB, Aziz Q, Nessa A, Tinker A and Hussain K (2014). Congenital hyperinsulinism: clinical and molecular characterisation of compound heterozygous ABCC8 mutation responsive to Diazoxide therapy. Springer Nature  International Journal of Pediatric Endocrinology  vol. 2014, (1) 10.1186/1687-9856-2014-24

Lambiase PD and Tinker A (2014). Connexins in the heart. Springer Nature  Cell and Tissue Research  vol. 360, (3) 675-684. 10.1007/s00441-014-2020-8

Lane JD, Abramowitz J, Birnbaumer L and Tinker A (2014). 51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure. Europace  vol. 16 Suppl 3, 10.1093/europace/euu241.1

Aziz Q, Thomas AM, Gomes J, Ang R, Sones WR, Li Y, Ng K-E, Gee L and Tinker A (2014). The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control. Hypertension  vol. 64, (3) 523-529. 10.1161/HYPERTENSIONAHA.114.03116

Harmer SC, Mohal JS, Royal AA, McKenna WJ, Lambiase PD and Tinker A (2014). Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1. Biochem J  vol. 462, (1) 133-142. 10.1042/BJ20140425

Tinker A, Aziz Q and Thomas A (2014). The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system. Br J Pharmacol  vol. 171, (1) 12-23. 10.1111/bph.12407

Youziel J, Akhbar AR, Aziz Q, Smith MEB, Caddick S, Tinker A and Baker JR (2014). Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. Organic & Biomolecular Chemistry  vol. 12, (4) 557-560. 10.1039/c3ob42141d

Tinker A and Harmer SC (2013). Potassium channels regulating the electrical activity of the heart. Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment  10.1007/978-0-85729-920-8_6

Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L and Tinker A (2013). The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins. Am J Physiol Regul Integr Comp Physiol  vol. 305, (4) R435-R442. 10.1152/ajpregu.00037.2013

Ang R, Birnbaumer L, Gourine AV and Tinker A (2013). The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart. Oxford University Press (Oup)  European Heart Journal  vol. 34, (suppl_1) p5030-p5030. 10.1093/eurheartj/eht310.p5030

Schwarzer S, Mashanov GI, Molloy JE and Tinker A (2013). Using total internal reflection fluorescence microscopy to observe ion channel trafficking and assembly. Methods Mol Biol  vol. 998, 201-208. 10.1007/978-1-62703-351-0_15

Telezhkin V, Thomas AM, Harmer SC, Tinker A and Brown DA (2013). A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂. Pflugers Archiv-European Journal of Physiology  vol. 465, (7) 945-953. 10.1007/s00424-012-1199-3

Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K and Martemyanov KA (2013). Essential Role of the m₂R-RGS6-I_KACh Pathway in Controlling Intrinsic Heart Rate Variability. Plos One  vol. 8, (10) 10.1371/journal.pone.0076973

Risebro CA, Petchey LK, Smart N, Gomes J, Clark J, Vieira JM, Yanni J, Dobrzynski H, Davidson S, Zuberi Z, Tinker A, Shui B, Tallini YI, Kotlikoff MI, Miquerol L, Schwartz RJ and Riley PR (2012). Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Circ Res  vol. 111, (2) e19-e31. 10.1161/CIRCRESAHA.111.260695

Harmer SC, Mohal JS, Kemp D and Tinker A (2012). Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel. Biochem J  vol. 443, (3) 635-642. 10.1042/BJ20111912

Tinker A (2012). The assembly and targeting of potassium channels. Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels  10.1093/acprof:oso/9780192632241.003.0002

Aziz Q, Thomas AM, Khambra T and Tinker A (2012). Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C. J Biol Chem  vol. 287, (9) 6196-6207. 10.1074/jbc.M111.243923

Telezhkin V, Reilly JM, Thomas AM, Tinker A and Brown DA (2012). Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding. Journal of Biological Chemistry  vol. 287, (13) 10001-10012. 10.1074/jbc.M111.322552

Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A and Ruhrberg C (2012). NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Developmental Biology  vol. 369, (2) 277-285. 10.1016/j.ydbio.2012.06.026

Ang R, Opel A and Tinker A (2012). The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias. Frontiers  Frontiers in Physiology  vol. 3, 10.3389/fphys.2012.00096

Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, TINKER A and Lambiase PD (2012). Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Oxford University Press  Eur Heart Journal  vol. 33, (15) 1942-1953. 10.1093/eurheartj/ehr472

Tinker A and Harmer SC (2011). Potassium Channels Regulating the Electrical Activity of the Heart. Translational Vascular Medicine  Springer Nature  10.1007/978-0-85729-920-8_6

Hothersall JD, Black J, Caddick S, Vinter JG, Tinker A and Baker JR (2011). The design, synthesis and pharmacological characterization of novel β2‐adrenoceptor antagonists. Wiley  British Journal of Pharmacology  vol. 164, (2) 317-331. 10.1111/j.1476-5381.2011.01269.x

Schumacher FF, Nobles M, Ryan CP, Smith MEB, Tinker A, Caddick S and Baker JR (2011). In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation. American Chemical Society (Acs)  Bioconjugate Chemistry  vol. 22, (2) 132-136. 10.1021/bc1004685

Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO and Shuba YM (2011). Sarcolemmal cardiac KATP channels as a target for the cardioprotective effects of the fluorine‐containing pinacidil analogue, flocalin. Wiley  British Journal of Pharmacology  vol. 162, (3) 701-711. 10.1111/j.1476-5381.2010.01072.x

Thomas AM, Harmer SC, Khambra T and Tinker A (2011). Characterization of a binding site for anionic phospholipids on KCNQ1. Journal of Biological Chemistry  vol. 286, 2088-2100. 10.1074/jbc.M110.153551

Kapoor RR, Flanagan SE, James CT, McKiernan J, Thomas AM, Harmer SC, Shield JP, Tinker A, Ellard S and Hussain K (2011). Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations. Diab Tologia  vol. 54, 2575-2583. 10.1007/s00125-011-2207-4

Bollini S, Pozzobon M, Nobles M, Riegler J, Dong X, Piccoli M, Chiavegato A, Price AN, Ghionzoli M, Cheung KK, Cabrelle A, O’Mahoney PR, Cozzi E, Sartore S, Tinker A, Lythgoe MF and De Coppi P (2010). In Vitro and In Vivo Cardiomyogenic Differentiation of Amniotic Fluid Stem Cells. Springer Nature  Stem Cell Reviews and Reports  vol. 7, (2) 364-380. 10.1007/s12015-010-9200-z

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M and Segal AW (2010). Retraction Note: The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Springer Nature  Nature  vol. 468, (7320) 122-122. 10.1038/nature09562

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A and Caddick S (2010). ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent β‐Blocker ICI‐118,551 Allows the Determination of Enantiomer Dependency on Biological Activity. Wiley  Cheminform  vol. 41, (43) no-no. 10.1002/chin.201043086

Schwarzer S, Nobles M and Tinker A (2010). Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?*. Elsevier  Journal of Biological Chemistry  vol. 285, (36) 27817-27826. 10.1074/jbc.m110.103598

Zuberi Z, Nobles M, Sebastian S, Dyson A, Lim SY, Breckenridge R, Birnbaumer L and Tinker A (2010). Absence of the Inhibitory G-Protein G&agr;i2 Predisposes to Ventricular Cardiac Arrhythmia. Wolters Kluwer  Circulation Arrhythmia and Electrophysiology  vol. 3, (4) 391-400. 10.1161/circep.109.894329

Ng K-E, Schwarzer S, Duchen MR and Tinker A (2010). The Intracellular Localization and Function of the ATP-Sensitive K+ Channel Subunit Kir6.1. Springer Nature  The Journal of Membrane Biology  vol. 234, (2) 137-147. 10.1007/s00232-010-9241-x

Nobles M, Sebastian S and Tinker A (2010). HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes. Springer Nature  PflüGers Archiv - European Journal of Physiology  vol. 460, (1) 99-108. 10.1007/s00424-010-0799-z

Aziz Q, Thomas A, Khambra T and Tinker A (2010). Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel. Elsevier  European Journal of Pharmacology  vol. 634, (1-3) 26-32. 10.1016/j.ejphar.2010.02.023

Mashanov GI, Nobles M, Harmer SC, Molloy JE and Tinker A (2010). Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior. Journal of Biological Chemistry  vol. 285, 3664-3675. 10.1074/jbc.M109.039974

Tinker A and Harmer SC (2010). K+ channels in the heart: new insights and therapeutic implications. Expert Rev Clin Pharmacol  vol. 3, 305-319. 10.1586/ecp.10.14

Harmer SC, Wilson AJ, Aldridge R and Tinker A (2010). Mechanisms of disease pathogenesis in long QT syndrome type 5. Am J Physiol Cell Physiol  vol. 298, C263-C273. 10.1152/ajpcell.00308.2009

Baker JR, Hothersall JD, Fitzmaurice RJ, Tucknott M, Vinter A, Tinker A and Caddick S (2010). An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. Royal Society of Chemistry (Rsc)  Chemical Communications  vol. 46, (22) 3953-3954. 10.1039/c0cc00142b

Orie N, Thomas A, Perrino B, Tinker A and Clapp L (2009). Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway. Wiley  British Journal of Pharmacology  vol. 157, (4) 554-564. 10.1111/j.1476-5381.2009.00221.x

Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJR, Tinker A and Mohun TJ (2009). Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice. Elsevier  Journal of Molecular and Cellular Cardiology  vol. 47, (1) 133-141. 10.1016/j.yjmcc.2009.04.007

Zuberi Z, Birnbaumer L and Tinker A (2008). The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics. American Physiological Society  Ajp Regulatory Integrative and Comparative Physiology  vol. 295, (6) r1822-r1830. 10.1152/ajpregu.90625.2008

Campanella M, Tan C, Abramov A, Tinker A and Duchen M (2008). S12/4 Mitochondria as ATP consumers: the cell biology of the endogenous inhibitory protein, IF1. Elsevier  Biochimica Et Biophysica Acta (Bba) - Bioenergetics  vol. 1777, 10.1016/j.bbabio.2008.05.299

Quinn KV, Behe P and Tinker A (2008). Monitoring changes in membrane phosphatidylinositol 4,5‐bisphosphate in living cells using a domain from the transcription factor tubby. Wiley  The Journal of Physiology  vol. 586, (12) 2855-2871. 10.1113/jphysiol.2008.153791

Farzaneh T and Tinker A (2008). Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits. Oxford University Press (Oup)  Cardiovascular Research  vol. 79, (4) 621-631. 10.1093/cvr/cvn138

Breckenridge RA, Zuberi Z, Felkin L, Birks E, Barton P, Tinker A and Mohun T (2008). 446 Overexpression of the transcription factor Hand1 causes sudden cardiac death in mice. Oxford University Press (Oup)  European Journal of Heart Failure Supplements  vol. 7, 109-109. 10.1016/s1567-4215(08)60301-x

Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AR, TINKER A and Duchen MR (2008). Regulation of mitochondrial structure and function by IF1, the endogenous inhibitor of the mitochondrial ATPase. Cell Metabolism  vol. 8, (1) 13-25. 10.1016/j.cmet.2008.06.001

Thomas AM and Tinker A (2008). Determination of Phosphoinositide Binding to K+ Channel Subunits Using a Protein—Lipid Overlay Assay. Springer Nature  10.1007/978-1-59745-526-8_8

Falcetti E, Flavell DM, Staels B, Tinker A, Haworth SG and Clapp LH (2007). IP receptor-dependent activation of PPARγ by stable prostacyclin analogues. Elsevier  Biochemical and Biophysical Research Communications  vol. 360, (4) 821-827. 10.1016/j.bbrc.2007.06.135

Muzyamba M, Farzaneh T, Behe P, Thomas A, Christesen HBT, Brusgaard K, Hussain K and Tinker A (2007). Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies. Wiley  Clinical Endocrinology  vol. 67, (1) 115-124. 10.1111/j.1365-2265.2007.02847.x

Hughes S, Marsh SJ, Tinker A and Brown DA (2007). PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons. Springer Nature  PflüGers Archiv - European Journal of Physiology  vol. 455, (1) 115-124. 10.1007/s00424-007-0259-6

Harmer SC and Tinker A (2007). The role of abnormal trafficking of KCNE1 in long QT syndrome 5. Biochemical Society Transactions  vol. 35, 1074-1076. 10.1042/BST0351074

Tennant BP, Cui Y, Tinker A and Clapp LH (2006). Functional Expression of Inward Rectifier Potassium Channels in Cultured Human Pulmonary Smooth Muscle Cells: Evidence for a Major Role of Kir2.4 Subunits. Springer Nature  The Journal of Membrane Biology  vol. 213, (1) 19-29. 10.1007/s00232-006-0037-y

Kang Y, Ng B, Leung Y-M, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG and Gaisano HY (2006). Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic pH-induced Cardiac KATP Channel Activation*. Elsevier  Journal of Biological Chemistry  vol. 281, (28) 19019-19028. 10.1074/jbc.m513160200

Thomas AM, Brown SG, Leaney JL and Tinker A (2006). Differential Phosphoinositide Binding to Components of the G Protein-Gated K+ Channel. Springer Nature  The Journal of Membrane Biology  vol. 211, (1) 43-53. 10.1007/s00232-006-0014-5

Tinker A (2006). The selective interactions and functions of regulators of G-protein signalling. Elsevier  Seminars in Cell and Developmental Biology  vol. 17, (3) 377-382. 10.1016/j.semcdb.2006.03.007

Nobles M, Benians A and Tinker A (2005). Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 102, (51) 18706-18711. 10.1073/pnas.0504778102

Wilson AJ, Quinn KV, Graves FM, Bitner-Glindzicz M and Tinker A (2005). Abnormal KCNQ1 trafficking influences disease pathogenesis in hereditary long QT syndromes (LQT1). Oxford University Press (Oup)  Cardiovascular Research  vol. 67, (3) 476-486. 10.1016/j.cardiores.2005.04.036

Brown SG, Thomas A, Dekker LV, Tinker A and Leaney JL (2005). PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells. American Physiological Society  American Journal of Physiology - Cell Physiology  vol. 289, (3) c543-c556. 10.1152/ajpcell.00025.2005

Benians A, Nobles M, Hosny S and Tinker A (2005). Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein A NOVEL EXPLANATION FOR THE ACCELERATION OF SIGNALING ACTIVATION KINETICS*. Elsevier  Journal of Biological Chemistry  vol. 280, (14) 13383-13394. 10.1074/jbc.m410163200

Morrissey A, Rosner E, Lanning J, Parachuru L, Dhar Chowdhury P, Han S, Lopez G, Tong X, Yoshida H, Nakamura TY, Artman M, Giblin JP, Tinker A and Coetzee WA (2005). Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Springer Nature  Bmc Physiology  vol. 5, (1) 10.1186/1472-6793-5-1

Quinn KV, Giblin JP and Tinker A (2004). Multisite Phosphorylation Mechanism for Protein Kinase A Activation of the Smooth Muscle ATP-Sensitive K+ Channel. Wolters Kluwer  Circulation Research  vol. 94, (10) 1359-1366. 10.1161/01.res.0000128513.34817.c4

Leaney JL, Benians A, Brown S, Nobles M, Kelly D and Tinker A (2004). Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle. American Physiological Society  American Journal of Physiology - Cell Physiology  vol. 287, (1) c182-c191. 10.1152/ajpcell.00540.2003

Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M and Segal AW (2004). The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Springer Nature  Nature  vol. 427, (6977) 853-858. 10.1038/nature02356

Quinn KV, Cui Y, Giblin JP, Clapp LH and Tinker A (2003). Do Anionic Phospholipids Serve as Cofactors or Second Messengers for the Regulation of Activity of Cloned ATP-Sensitive K+ Channels? Wolters Kluwer  Circulation Research  vol. 93, (7) 646-655. 10.1161/01.res.0000095247.81449.8e

Cui Y, Tinker A and Clapp LH (2003). Different molecular sites of action for the KATP channel inhibitors, PNU‐99963 and PNU‐37883A. Wiley  British Journal of Pharmacology  vol. 139, (1) 122-128. 10.1038/sj.bjp.0705228

Benians A, Leaney JL and Tinker A (2003). Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 100, (10) 6239-6244. 10.1073/pnas.1037595100

Benians A, Leaney JL, Milligan G and Tinker A (2003). The Dynamics of Formation and Action of the Ternary Complex Revealed in Living Cells Using a G-protein-gated K+ Channel as a Biosensor*. Elsevier  Journal of Biological Chemistry  vol. 278, (12) 10851-10858. 10.1074/jbc.m212299200

Giblin JP, Quinn K and Tinker A (2002). The cytoplasmic C‐terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking. Wiley  The Febs Journal  vol. 269, (21) 5303-5313. 10.1046/j.1432-1033.2002.03249.x

Lawrence KM, Chanalaris A, Scarabelli T, Hubank M, Pasini E, Townsend PA, Comini L, Ferrari R, Tinker A, Stephanou A, Knight RA and Latchman DS (2002). KATP Channel Gene Expression Is Induced by Urocortin and Mediates Its Cardioprotective Effect. Wolters Kluwer  Circulation  vol. 106, (12) 1556-1562. 10.1161/01.cir.0000028424.02525.ae

Leaney JL, Benians A, Graves FM and Tinker A (2002). A Novel Strategy to Engineer Functional Fluorescent Inhibitory G-protein α Subunits*. Elsevier  Journal of Biological Chemistry  vol. 277, (32) 28803-28809. 10.1074/jbc.m204683200

Clapp LH, Finney P, Turcato S, Tran S, Rubin LJ and Tinker A (2002). Differential Effects of Stable Prostacyclin Analogs on Smooth Muscle Proliferation and Cyclic AMP Generation in Human Pulmonary Artery. American Thoracic Society  American Journal of Respiratory Cell and Molecular Biology  vol. 26, (2) 194-201. 10.1165/ajrcmb.26.2.4695

Giblin JP, Cui Y, Clapp LH and Tinker A (2002). Assembly Limits the Pharmacological Complexity of ATP-sensitive Potassium Channels*. Elsevier  Journal of Biological Chemistry  vol. 277, (16) 13717-13723. 10.1074/jbc.m112209200

Cui Y, Tran S, Tinker A and Clapp LH (2002). The Molecular Composition of KATP Channels in Human Pulmonary Artery Smooth Muscle Cells and Their Modulation by Growth. American Thoracic Society  American Journal of Respiratory Cell and Molecular Biology  vol. 26, (1) 135-143. 10.1165/ajrcmb.26.1.4622

Huang L, Bitner-Glindzicz M, Tranebjærg L and Tinker A (2001). A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome. Oxford University Press (Oup)  Cardiovascular Research  vol. 51, (4) 670-680. 10.1016/s0008-6363(01)00350-9

Leaney JL, Dekker LV and Tinker A (2001). Regulation of a G protein‐gated inwardly rectifying K+ channel by a Ca2+‐independent protein kinase C. Wiley  The Journal of Physiology  vol. 534, (2) 367-379. 10.1111/j.1469-7793.2001.00367.x

Cui Y, Giblin JP, Clapp LH and Tinker A (2001). A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 98, (2) 729-734. 10.1073/pnas.98.2.729

Graves FM and Tinker A (2000). Functional Expression of the Pore Forming Subunit of the ATP-Sensitive Potassium Channel in Saccharomyces cerevisiae. Elsevier  Biochemical and Biophysical Research Communications  vol. 272, (2) 403-409. 10.1006/bbrc.2000.2798

Leaney JL and Tinker A (2000). The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 97, (10) 5651-5656. 10.1073/pnas.080572297

Leaney JL, Milligan G and Tinker A (2000). The G Protein α Subunit Has a Key Role in Determining the Specificity of Coupling to, but Not the Activation of, G Protein-gated Inwardly Rectifying K+ Channels*. Elsevier  Journal of Biological Chemistry  vol. 275, (2) 921-929. 10.1074/jbc.275.2.921

Giblin JP, Leaney JL and Tinker A (1999). The Molecular Assembly of ATP-sensitive Potassium Channels DETERMINANTS ON THE PORE FORMING SUBUNIT*. Elsevier  Journal of Biological Chemistry  vol. 274, (32) 22652-22659. 10.1074/jbc.274.32.22652

Tinker A and Jan LY (1999). Chapter 9 The Assembly of Inwardly Rectifying Potassium Channels. Elsevier  10.1016/s0070-2161(08)60925-9

Lucie H and Tinker A (1998). Potassium channels in the vasculature. Wolters Kluwer  Current Opinion in Nephrology & Hypertension  vol. 7, (1) 83-98. 10.1097/00041552-199801000-00015

Welch W, Williams AJ, Tinker A, Mitchell KE, Deslongchamps P, Lamothe J, Gerzon K, Bidasee KR, Besch HR, Airey JA, Sutko JL and Ruest L (1997). Structural Components of Ryanodine Responsible for Modulation of Sarcoplasmic Reticulum Calcium Channel Function †. American Chemical Society (Acs)  Biochemistry  vol. 36, (10) 2939-2950. 10.1021/bi9623901

Tinker A, Jan YN and Jan LY (1996). Regions Responsible for the Assembly of Inwardly Rectifying Potassium Channels. Elsevier  Cell  vol. 87, (5) 857-868. 10.1016/s0092-8674(00)81993-5

Tinker A, Sutko JL, Ruest L, Deslongchamps P, Welch W, Airey JA, Gerzon K, Bidasee KR, Besch HR and Williams AJ (1996). Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel. Elsevier  Biophysical Journal  vol. 70, (5) 2110-2119. 10.1016/s0006-3495(96)79777-1

Tinker A and Williams AJ (1995). Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers. Elsevier  Biophysical Journal  vol. 68, (1) 111-120. 10.1016/s0006-3495(95)80165-7

Lindsay AR, Tinker A and Williams AJ (1994). How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel? Rockefeller University Press  The Journal of General Physiology  vol. 104, (3) 425-447. 10.1085/jgp.104.3.425

Tinker A and Williams AJ (1993). Probing the structure of the conduction pathway of the sheep cardiac sarcoplasmic reticulum calcium-release channel with permeant and impermeant organic cations. Rockefeller University Press  The Journal of General Physiology  vol. 102, (6) 1107-1129. 10.1085/jgp.102.6.1107

Tinker A and Williams AJ (1993). Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel. Elsevier  Biophysical Journal  vol. 65, (4) 1678-1683. 10.1016/s0006-3495(93)81201-3

Tinker A, Lindsay ARG and Williams AJ (1993). Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions. Oxford University Press (Oup)  Cardiovascular Research  vol. 27, (10) 1820-1825. 10.1093/cvr/27.10.1820

Tinker A and Williams AJ (1993). Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel. Elsevier  Biophysical Journal  vol. 65, (2) 852-864. 10.1016/s0006-3495(93)81104-4

Tinker A and Williams AJ (1992). Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. Rockefeller University Press  The Journal of General Physiology  vol. 100, (3) 479-493. 10.1085/jgp.100.3.479

Tinker A, Lindsay AR and Williams AJ (1992). A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum. Rockefeller University Press  The Journal of General Physiology  vol. 100, (3) 495-517. 10.1085/jgp.100.3.495

Tinker A, Lindsay AR and Williams AJ (1992). Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel. Elsevier  Biophysical Journal  vol. 61, (5) 1122-1132. 10.1016/s0006-3495(92)81922-7

Tinker A, Lindsay ARG and Williams AJ (1992). Block of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by tetra-alkyl ammonium cations. Springer Nature  The Journal of Membrane Biology  vol. 127, (2) 149-159. 10.1007/bf00233287