Prof Gareth Ackland
Clinical Professor of Perioperative Medicine
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
myocardial injury, organ dysfunction after surgery, inflammation, sepsis, autonomic function
Interests
Ex vivo human studies- largely high-risk surgical patients.Publications
2024
Hughes C, Ackland G and Shelley B (2024). Perioperative myocardial injury. Elsevier BJA Education vol. 24, (10) 352-360.
Theparambil SM, Kopach O, Braga A, Nizari S, Hosford PS, Sagi-Kiss V, Hadjihambi A, Konstantinou C, Esteras N, Gutierrez Del Arroyo A, Ackland GL, Teschemacher AG, Dale N, Eckle T, Andrikopoulos P, Rusakov DA, Kasparov S and Gourine AV (2024). Adenosine signalling to astrocytes coordinates brain metabolism and function. Springer Nature Nature vol. 632, (8023) 139-146.
Thomas M, Hayes K, White P, Baumer T, Beattie C, Ramesh A, Culliford L, Ackland GL and Pickering AE (2024). Early Intravenous Beta-Blockade with Esmolol in Adults with Severe Traumatic Brain Injury: A Phase 2a Intervention Design Study. Springer Nature Neurocritical Care 1-11.
Mi Y, Burnham KL, Charles PD, Heilig R, Vendrell I, Whalley J, Torrance HD, Antcliffe DB, May SM, Neville MJ, Berridge G, Hutton P, Geoghegan CG, Radhakrishnan J, Nesvizhskii AI, Yu F, Davenport EE, McKechnie S, Davies R, O’Callaghan DJP, Patel P, del Arroyo AG, Karpe F, Gordon AC, Ackland GL, Hinds CJ, Fischer R, Knight JC, Webster N and Galley H (2024). High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response. American Association for the Advancement of Science (AAAS) Science Translational Medicine vol. 16, (750)
Vail EA and Ackland GL (2024). The BJA Editorial Fellowship 2024: a barometer for the state of academic anaesthesiology, perioperative, pain, and critical care medicine. Elsevier British Journal of Anaesthesia vol. 133, (1) 3-6.
Janssen H, Jhanji S, Oliver NS, Ackland GL, Investigators FTG, Korbonits M, Henson S, Yeung J, Pearse R, Shelley B, Hiller L, Jacob P, Noblet J, Jefford M, del Arroyo AG, Samman A, Alharbi S, Ahuja S and Dias P (2024). Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction. Elsevier British Journal of Anaesthesia vol. 132, (5) 843-848.
del Arroyo AG, Patel A, Abbott TEF, Begum S, Dias P, Somanath S, Middleditch A, Cleland S, Brealey D, Pearse RM, Ackland GL, Ackland G, Martin T, Fernandez M, Seidu F, Pakats M-L, Mahr O, MacDonald N, Dos Santos F, Garcia AA, Uddin R, Begum S, Pearse R, Subhedar E, Wan Y, Shahid T, Gooneratne M, Trainer C and Griffiths B (2024). Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial. Elsevier British Journal of Anaesthesia vol. 132, (5) 857-866.
Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Del Arroyo AG, Crescente M, Tinker A, Ackland GL and Gourine AV (2024). Transcriptional response of the heart to vagus nerve stimulation. Physiol Genomics vol. 56, (2) 167-178.
Bollen Pinto B and Ackland GL (2024). Pathophysiological mechanisms underlying increased circulating cardiac troponin in noncardiac surgery: a narrative review. Elsevier British Journal of Anaesthesia vol. 132, (4) 653-666.
Prowle JR, Croal B, Abbott TEF, Cuthbertson BH, Wijeysundera DN, Myles PS, Shulman MA, Wallace S, Farrington C, Thompson B, Ellis M, Borg B, Kerridge RK, Douglas J, Brannan J, Pretto J, Godsall MG, Beauchamp N, Allen S, Kennedy A, Wright E, Malherbe J, Ismail H, Riedel B, Melville A, Sivakumar H, Murmane A, Kenchington K, Kirabiyik Y and Gurunathan U (2024). Cystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study. Oxford University Press (OUP) Clinical Kidney Journal vol. 17, (1)
Polok K, Biccard BM, Chan MTV, Archbold RA, Wang CY, Sigamani A, Urrútia G, Cruz P, Srinathan SK, Szalay D, Harlock J, Tittley JG, Elias F, Jacka MJ, Malaga G, Berwanger O, Studzińska D, Górka J, Montes FR, Chow CK, Ackland GL, Dubois L, Sapsford RJ, Williams C, Cortés OL, Devereaux PJ and Szczeklik W (2024). Mortality and major postoperative complications within 1 year after vascular surgery: a prospective cohort study. "Medycyna Praktyczna" Spolka Jawna Polish Archives of Internal Medicine vol. 134, (2)
2023
Ackland GL, Martin T, Joseph M, Dias P, Hameed R, del Arroyo AG, Hewson R, Abbott TEF, Spooner O and Bhogal P (2023). Transauricular nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: Protocol for a phase 2A, proof-of-concept, sham-controlled randomised trial. Public Library of Science (PLoS) PLOS ONE vol. 18, (12)
Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A, Ackland GL and Gourine AV (2023). Transcriptional response of the heart to vagus nerve stimulation. Physiol Genomics
Lurati Buse G, Bollen Pinto B, Abelha F, Abbott TEF, Ackland G, Afshari A, De Hert S, Fellahi JL, Giossi L, Kavsak P, Longrois D, M'Pembele R, Nucaro A, Popova E, Puelacher C, Richards T, Roth S, Sheka M, Szczeklik W, Van Waes J, Walder B and Chew MS (2023). ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation. European Journal of Anaesthesiology vol. 40, (12) 888-927.
Ackland G (2023). Discontinuation vs. continuation of renin–angiotensin system inhibition before non-cardiac surgery: the SPACE trial. Oxford University Press European Heart Journal
James A, Bruce D, Tetlow N, Patel ABU, Black E, Whitehead N, Ratcliff A, Humphreys AJ, MacDonald N, McDonnell G, Raobaikady R, Thirugnanasambanthar J, Ravindran JI, Minto G, Abbott TEF, Jhanji S, Milliken D and Ackland GL (2023). Heart rate recovery after orthostatic challenge and cardiopulmonary exercise testing in older individuals: prospective multicentre observational cohort study. Elsevier BJA Open vol. 8,
Roshanov PS, Chan MTV, Borges FK, Conen D, Wang CY, Xavier D, Berwanger O, Marcucci M, Sessler DI, Szczeklik W, Spence J, Alonso-Coello P, Fernández C, Pearse RM, Malaga G, Garg AX, Srinathan SK, Jacka MJ, Tandon V, McGillion M, Popova E, Sigamani A, Abraham V, Biccard BM, Villar JC, Chow CK, Polanczyk CA, Tiboni M, Whitlock R and Ackland GL (2023). One-year Outcomes after Discharge from Noncardiac Surgery and Association between Predischarge Complications and Death after Discharge: Analysis of the VISION Prospective Cohort Study. Wolters Kluwer Anesthesiology vol. 140, (1) 8-24.
Keast T, McErlane J, Kearns R, McKinlay S, Raju I, Watson M, Robertson KE, Berry C, Greenlaw N, Ackland G, McCall P and Shelley B (2023). Study protocol for IMPRoVE: a multicentre prospective observational cohort study of the incidence, impact and mechanisms of perioperative right ventricular dysfunction in non-cardiac surgery. BMJ BMJ Open vol. 13, (9)
Korsak A, Kellett DO, Aziz Q, Anderson C, D’Souza A, Tinker A, Ackland GL and Gourine AV (2023). Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training. Oxford University Press (OUP) Cardiovascular Research vol. 119, (13) 2329-2341.
Kopach O, Sylantyev S, Bard L, Michaluk P, Heller JP, del Arroyo AG, Ackland GL, Gourine AV and Rusakov DA (2023). Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release. Elsevier iScience vol. 26, (7)
Thomas M, Hayes K, White P, Ramesh A, Culliford L, Ackland G and Pickering A (2023). Early Intravenous Beta-Blockade with Esmolol in Adults with Severe Traumatic Brain Injury (EBB-TBI): Protocol for a Phase 2a Intervention Design Study. Springer Nature Neurocritical Care vol. 40, (2) 795-806.
Edwards MR, Forbes G, Walker N, Morton DG, Mythen MG, Murray D, Anderson I, Mihaylova B, Thomson A, Taylor M, Hollyman M, Phillips R, Young K, Kahan BC, Pearse RM and Grocott MPW (2023). Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery. Springer Nature Trials vol. 24, (1)
Patel ABU, Bibawy PPWM, Althonayan JIM, Majeed Z, Gan WL, Abbott TEF and Ackland GL (2023). Effect of transauricular nerve stimulation on perioperative pain: a single-blind, analyser-masked, randomised controlled trial. Elsevier British Journal of Anaesthesia
2022
Lan-Pak-Kee V, Ackland GL, Egan TC, Abbott TE, Elsheikh F, Investigators TACWU, Barrett S, Gooneratne M, May SM, Mitchard M, O'Neill T, Overend J, Abbott TE, Pang C-L, Radhakrishnan A, Reynolds T, Vadher M, Verma P, Wikner M and Wood A (2022). Arterial cannulation with ultrasound: clinical trial protocol for a randomised controlled trial comparing handheld ultrasound versus palpation technique for radial artery cannulation. Elsevier BJA Open vol. 4,
Walker SLM, Muthoo C, Sanchez J, Del Arroyo AG and Ackland GL (2022). Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis. Springer Nature Intensive Care Medicine Experimental vol. 10, (1)
Patel ABU, Bibawy PPWM, Majeed Z, Gan WL and Ackland GL (2022). Trans-auricular vagus nerve stimulation to reduce perioperative pain and morbidity: protocol for a single-blind analyser-masked randomised controlled trial. Elsevier BJA Open vol. 2,
Ali A, Weber V, Thompson SJ, Abbott TEF, Harmston R, David AL, Ackland GL and investigators FTE (2022). IL-1ra polymorphisms and risk of epidural-related maternal fever (EPIFEVER-2): study protocol for a multicentre, observational mechanistic cohort study. Elsevier International Journal of Obstetric Anesthesia vol. 50,
Ackland G and ABBOTT T (2022). Hypotension as a marker or mediator of perioperative organ injury: a review. Elsevier British Journal of Anaesthesia
Abbott TEF and Ackland GL (2022). Reply to: Monitors are not a treatment. Eur J Anaesthesiol vol. 39, (2) 180-180.
Jones TF, Iakovou D, Makariou N, Fowler AJ and Ackland GL (2022). Metformin and mortality after surgery: a systematic review and meta-analysis. Elsevier British Journal of Anaesthesia vol. 128, (4) e277-e279.
Ackland GL, Walker SLM and Jones TF (2022). 2 The Inflammatory Response to Surgery. Perioperative Medicine Elsevier
2021
Ackland G, Van Duijvenboden S, ABBOTT T, Gutierrez Del Arroyo A, Wilson M and David A (2021). Interleukin-1 receptor antagonist and risk of caesarean delivery after onset of labour: a Mendelian randomisation analysis. Elsevier British Journal of Anaesthesia
Patel ABU, Weber V, Gourine AV and Ackland GL (2021). The potential for autonomic neuromodulation to reduce perioperative complications and pain: a systematic review and meta-analysis. Elsevier British Journal of Anaesthesia vol. 128, (1) 135-149.
May SM, Chiang E, Reyes A, Martir G, Patel A, Karmali S, Patel S, West S, del Arroyo AG, Gourine AV and Ackland GL (2021). Immunomodulation of innate immunity by brachial plexus blockade: a crossover study. British Journal of Anaesthesia vol. 127, (3) e116-e118.
May SM, Chiang E, Reyes A, Martir G, Patel A, Karmali S, Patel S, West S, del Arroyo AG, Gourine AV and Ackland GL (2021). Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study. Elsevier Brain Behavior & Immunity - Health vol. 16,
Heywood WE, Bliss E, Bahelil F, Cyrus T, Crescente M, Jones T, Iqbal S, Paredes LG, Toner AJ, Del Arroyo AG, O'Toole EA, Mills K and Ackland GL (2021). Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial. Elsevier British Journal of Anaesthesia vol. 127, (4) 511-520.
Pearse RM, Ackland GL, Asai T and Hemmings HC (2021). Preprints in perioperative medicine: immediacy for the greater good. Elsevier British Journal of Anaesthesia vol. 126, (5) 915-918.
Schroth J, Weber V, Jones TF, Del Arroyo AG, Henson SM and Ackland GL (2021). Preoperative lymphopaenia, mortality, and morbidity after elective surgery: systematic review and meta-analysis. Elsevier British Journal of Anaesthesia
Farmer AD, Strzelczyk A, Finisguerra A, Gourine AV, Gharabaghi A, Hasan A, Burger AM, Jaramillo AM, Mertens A, Majid A, Verkuil B, Badran BW, Ventura-Bort C, Gaul C, Beste C, Warren CM, Quintana DS, Hämmerer D, Freri E, Frangos E, Tobaldini E, Kaniusas E, Rosenow F, Capone F, Panetsos F, Ackland GL, Kaithwas G, O'Leary GH, Genheimer H and Jacobs HIL (2021). International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020). Frontiers Frontiers in Human Neuroscience vol. 14,
Abbott TEF, Howell S, Pearse RM and Ackland GL (2021). Mode of blood pressure monitoring and morbidity after noncardiac surgery: A prospective multicentre observational cohort study. European Journal of Anaesthesiology vol. 38, (5) 468-476.
2020
Weber V, Abbott TEF and Ackland GL (2020). Reducing the dose of neuromuscular blocking agents with adjuncts: a systematic review and meta-analysis. Elsevier British Journal of Anaesthesia vol. 126, (3) 608-621.
Booth LC, Yao ST, Korsak A, Farmer DGS, Hood SG, McCormick D, Boesley Q, Connelly AA, McDougall SJ, Korim WS, Guild S-J, Mastitskaya S, Le P, Teschemacher AG, Kasparov S, Ackland GL, Malpas SC, McAllen RM, Allen AM, May CN and Gourine AV (2020). Selective optogenetic stimulation of efferent fibers in the vagus nerve of a large mammal. Elsevier Brain Stimulation vol. 14, (1) 88-96.
Shrimpton AJ, Walker SLM and Ackland GL (2020). Angiotensin converting enzyme inhibitors and angiotensin receptor blockers. Elsevier BJA Education vol. 20, (11) 362-367.
May S, Abbott TEF, Gutierrez Del Arroyo A, Reyes A, Martir G, Stephens RCM, Brealey D, Cuthbertson B, Wijeysundera D, Pearse R and Ackland G (2020). MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study. Elsevier British Journal of Anaesthesia vol. 125, (5) 661-671.
May SM, Abbott TEF, Del Arroyo AG, Reyes A, Martir G, Stephens RCM, Brealey D, Cuthbertson BH, Wijeysundera DN, Pearse RM and Ackland GL (2020). MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study. Elsevier British Journal of Anaesthesia vol. 125, (5) 661-671.
Riedel B, Li MHG, Lee CHA, Ismail H, Cuthbertson BH, Wijeysundera DN, Ho KM, Wallace S, Thompson B, Ellis M, Borg B, Kerridge RK, Douglas J, Brannan J, Pretto J, Godsall MG, Beauchamp N, Allen S, Kennedy A, Wright E, Malherbe J, Melville A, Sivakumar H, Murmane A, Kenchington K, Kirabiyik Y, Gurunathan U and Stonell C (2020). A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study. British Journal of Anaesthesia
Machhada A, Hosford PS, Dyson A, Ackland GL, Mastitskaya S and Gourine AV (2020). Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure. JACC Basic to Translational Science
Wan YI, Patel A, ABBOTT TEF, Achary C, Macdonald N, Duceppe E, Sessler DI, Szczeklik W, Ackland GL, Devereaux PJ and Pearse RM (2020). Prospective observational study of postoperative infection and outcomes after noncardiac surgery: analysis of prospective data from the VISION cohort. Elsevier BV British Journal of Anaesthesia
Hadjihambi A, Karagiannis A, Theparambil SM, Ackland GL and Gourine AV (2020). The effect of general anaesthetics on brain lactate release. Elsevier European Journal of Pharmacology vol. 881,
Ackland GL, ABBOTT T, Jones TF, Leuwer M, Pearse R, Niebrzegowska E, Wragg A, Archbold A, Kam E, Everingham K, Bodger P, Creary T, Bloom B, Carter A, MacDonald N, Shah N, Mrozek K, Richardson A, Fowler A, Rob Z, Ackland G, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Edwards M, Woldman S and Gutierrez del Arroyo A (2020). Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study. Elsevier British Journal of Anaesthesia
Duceppe E, Patel A, Chan MTV, Berwanger O, Ackland G, Kavsak PA, Rodseth R, Biccard B, Chow CK, Borges FK, Guyatt G, Pearse R, Sessler DI, Heels-Ansdell D, Kurz A, Wang CY, Szczeklik W, Srinathan S, Garg AX, Pettit S, Sloan EN, Januzzi JL, McQueen M, Buse GL, Mills NL, Zhang L, Sapsford R, Paré G, Walsh M and Whitlock R (2020). Preoperative n-terminal pro-b-type natriuretic peptide and cardiovascular events after noncardiac surgery: A cohort study. Annals of Internal Medicine vol. 172, (2) 96-104.
Ackland GL (2020). 40 What happens to the autonomic nervous system in critical illness? Evidence-Based Practice of Critical Care Elsevier
2019
Wijeysundera D, Beattie WS, Hillis G, ABBOTT T, Shulman M, Ackland G, Mazer D, Myles P, Pearse R and Cuthbertson B (2019). Integration of the Duke Activity Status Index into Preoperative Risk Evaluation: A Multicentre Prospective Cohort Study. Elsevier British Journal of Anaesthesia
Ackland GL, Abbott TEF, Minto G, Clark M, Owen T, Prabhu P, May SM, Reynolds JA, Cuthbertson BH, Wijeysundera D and Pearse RM (2019). Correction: Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies. Public Library of Science (PLoS) PLOS ONE vol. 14, (12)
Patel ABU and Ackland GL (2019). Inotropes and Vasopressors for Shock. Decker DeckerMed Transitional Year Weekly Curriculum™
Patel ABU, May SM, Reyes A, Martir G, Brealey D, Stephens RCM, Abbott TEF and Ackland GL (2019). Elevated heart rate after non-cardiac surgery: post-hoc analysis of a prospective observational cohort study. Cold Spring Harbor Laboratory
Zarbock A, Kellum JA, Gourine AV and Ackland GL (2019). Salvaging remote ischaemic preconditioning as a therapy for perioperative acute kidney injury. Elsevier British Journal of Anaesthesia vol. 124, (1) 8-12.
Walker S, Del Arroyo AG, Sanchez J and Ackland GL (2019). P3509Leukocyte derived tumour necrosis factor modulates cardiac function in health and disease. Oxford University Press (OUP) European Heart Journal vol. 40, (Supplement_1)
Manou-Stathopoulou V, Korbonits M and Ackland GL (2019). Redefining the perioperative stress response: a narrative review. Elsevier British Journal of Anaesthesia vol. 123, (5) 570-583.
Stephens TJ, Peden CJ, Haines R, Grocott MPW, Murray D, Cromwell D, Johnston C, Hare S, Lourtie J, Drake S, Martin GP and Pearse RM (2019). Hospital-level evaluation of the effect of a national quality improvement programme: time-series analysis of registry data. BMJ Publishing Group BMJ Quality and Safety
May SM, Reyes A, Martir G, Reynolds J, Paredes LG, Karmali S, Stephens RCM, Brealey D and Ackland GL (2019). Acquired loss of cardiac vagal activity is associated with myocardial injury in patients undergoing noncardiac surgery: prospective observational mechanistic cohort study. Elsevier British Journal of Anaesthesia vol. 123, (6) 758-767.
Peden CJ, Stephens T, Martin G, Kahan BC, Thomson A, Everingham K, Kocman D, Lourtie J, Drake S, Girling A, Lilford R, Rivett K, Wells D, Mahajan R, Holt P, Yang F, Walker S, Richardson G, Kerry S, Anderson I, Murray D, Cromwell D, Phull M, Grocott MP, Bion J and Pearse RM (2019). A national quality improvement programme to improve survival after emergency abdominal surgery: the EPOCH stepped-wedge cluster RCT. National Institute for Health and Care Research Health and Social Care Delivery Research vol. 7, (32) 1-96.
del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, Nightingale TD, Lambden S, Grant SGN, Gourine AV and Ackland GL (2019). NMDA receptor modulation of glutamate release in activated neutrophils. Elsevier BV EBioMedicine
Ackland GL, Abbott TEF, Minto G, Clark M, Owen T, Prabhu P, May SM, Reynolds JA, Cuthbertson BH, Wijeysundera D and Pearse RM (2019). Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies. PLoS ONE vol. 14, (8)
The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators (2019). Association between complications and death within 30 days after noncardiac surgery. Joule Inc. Canadian Medical Association Journal vol. 191, (30) E830-E837.
Lau EYM, Carroll EC, Callender LA, Hood GA, Berryman V, Pattrick M, Finer S, Hitman GA, Ackland GL and Henson SM (2019). Type 2 diabetes is associated with the accumulation of senescent T cells. Wiley Clinical & Experimental Immunology
Bartoszko J, Thorpe KE, Laupacis A, Wijeysundera DN, Myles PS, Shulman MA, Wallace S, Farrington C, Thompson B, Ellis M, Borg B, Kerridge RK, Douglas J, Brannan J, Pretto J, Godsall MG, Beauchamp N, Allen S, Kennedy A, Wright E, Malherbe J, Ismail H, Riedel B, Melville A, Sivakumar H, Murmane A, Kenchington K, Kirabiyik Y, Gurunathan U and Stonell C (2019). Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study. British Journal of Anaesthesia
Ackland GL and Pryor KO (2019). Electroencephalography-guided anaesthetic administration does not impact postoperative delirium among older adults undergoing major surgery: an independent discussion of the ENGAGES trial. Elsevier British Journal of Anaesthesia vol. 123, (2) 112-117.
ABBOTT TEF, PEARSE RM, beattie S, Phull M, Beilstein C, Raj A, Grocott M, Cuthbertson B, Wijeysundera D and ACKLAND GL (2019). Chronotropic incompetence and myocardial injury after non-cardiac surgery: planned secondary analysis of a prospective observational international cohort study. Elsevier BJA: British Journal of Anaesthesia vol. 123, (1) 17-26.
PEARSE RM, Peden C, STEPHENS T, Martin G, KAHAN B, Thomson A, Rivett K, Wells D, Richardson G, KERRY SM and Bion J (2019). Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery:
A stepped-wedge cluster randomised trial. Elsevier Lancet
Sessler DI, Bloomstone JA, Aronson S, Berry C, Gan TJ, Kellum JA, Plumb J, Mythen MG, Grocott MPW, Edwards MR, Miller TE, workgroup TPQI, chairs P, Grocott MP, group P, Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG, Lacey J, Pinsky MR, group PBP, Sanders R, Hughes F, Bader A and Thompson A (2019). Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery. Elsevier British Journal of Anaesthesia vol. 122, (5) 563-574.
Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG, Lacey J, Pinsky MR, Grocott MP, Mythen MG, Edwards MR, Miller TE, workgroup PQI, chairs P, group P, Ackland GL, group PBP, Sanders R, Hughes F, Bader A, Thompson A, Hoeft A, Williams D and Shaw AD (2019). Perioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicine. Elsevier British Journal of Anaesthesia vol. 122, (5) 542-551.
Pinto BB, Filipovic M and Ackland G (2019). Intra-operative heart rate and postoperative outcomes – rowing against the tide? Wolters Kluwer European Journal of Anaesthesiology vol. 36, (2) 90-92.
McEvoy MD, Gupta R, Koepke EJ, Feldheiser A, Michard F, Levett D, Thacker JKM, Hamilton M, Grocott MPW, Mythen MG, Miller TE, Edwards MR, Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG, Lacey J, Pinsky MR, Sanders R, Hughes F, Bader A, Thompson A, Hoeft A, Williams D, Shaw AD, Sessler DI, Aronson S, Berry C and Gan TJ (2019). Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery. British Journal of Anaesthesia
Gourine AV and Ackland GL (2019). Cardiac Vagus and Exercise. Physiology (Bethesda) vol. 34, (1) 71-80.
ACKLAND GL (2019). Perioperative Quality Initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery. Elsevier British Journal of Anaesthesia
Ackland GL (2019). Autonomic Dysfunction in Shock. Hemodynamic Monitoring Springer Nature
Abbott TEF, Pearse RM, Cuthbertson BH, Wijeysundera DN and Ackland GL (2019). Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study. British Journal of Anaesthesia
2018
del Arroyo AG, Sanchez J, Patel S, Phillips S, Reyes A, Cubillos C, Fernando R, David AL, Reeve A, Sodha S, Ciechanowicz S, Olearo E, Dick J, Stewart A, Sultan P and Ackland GL (2018). Role of leucocyte caspase-1 activity in epidural-related maternal fever: a single-centre, observational, mechanistic cohort study. British Journal of Anaesthesia
Ackland GL, Galley HF, Shelley B and Lambert DG (2018). Perioperative medicine and UK plc. British Journal of Anaesthesia
Ackland GL, Abbott TEF, Cain D, Edwards MR, Sultan P, Karmali SN, Fowler AJ, Whittle JR, MacDonald NJ, Reyes A, Paredes LG, Stephens RCM, Del Arroyo AG, Woldman S, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E and Pearse RM (2018). Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery. British Journal of Anaesthesia
TORRANCE H, LONGBOTTOM R, VIVIAN M, Lalabekyan B, ABBOTT TEF, ACKLAND GL, HINDS CJ, PEARSE RM and O'DWYER M (2018). Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery. Public Library of Science (PLoS) PLoS ONE vol. 13, (9)
Jones TF, Torrance HDT, Owen HC, Brohi K, Barnes MR, Knight JC, Hinds CJ, Ackland GL and O’Dwyer MJ (2018). MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism? Elsevier British Journal of Anaesthesia vol. 121, (2) e23-e24.
Wijeysundera D, PEARSE R, shulman M, ABBOTT TEF, Torres E, Ambosta A, Bernard C, Granton J, Thorpe K, Grocott M, Farrington C, Myles P and Cuthbertson B (2018). Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Elsevier Lancet vol. 391, (10140) 2631-2640.
WALKER S, ABBOTT TEF, Brown K, PEARSE R and ACKLAND G (2018). Perioperative management of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of perioperative medicine practitioners. PeerJ Inc. PeerJ
Lurati Buse G, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC, Sigamani A, Sessler DI, Berwanger O, Biccard BM, Pearse R, Urrútia G, Szczeklik RW, Garutti I, Srinathan S, Malaga G, Abraham V, Chow CK, Jacka MJ, Tiboni M, Ackland G, Macneil D, Sapsford R, Leuwer M, Le Manach Y and Devereaux PJ (2018). Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost–consequence analysis. Canadian Journal of Surgery vol. 61, (3) 185-194.
May S, Karmali S, Reyes A, Paredes LG, Martir G, Stephens R, Brealey D and Ackland G (2018). Serial holter recordings in non-cardiac surgery patients reveal postoperative autonomic impairment within 48 hours. Elsevier British Journal of Anaesthesia vol. 120, (5) e16-e17.
ackland GL, ABBOTT T, Pearse RM, Karmali S, Whittle J and Minto G (2018). Arterial pulse pressure and postoperative morbidity in high-risk surgical patients. Elsevier British Journal of Anaesthesia vol. 120, (1) 94-100.
2017
ABBOTT T, pearse RM, Archbold RA, Ahmad T, Niebrzegowska E, Wragg A, Rodseth R, Devereaux PJ and Ackland G (2017). A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study. Lippincott, Williams & Wilkins Anesthesia and Analgesia vol. 126, (6) 1936-1945.
ACKLAND GL, Minto G, Clark M, Whittle J, Stephens RCM, Owen T, Prabhu P and del Arroyo AG (2017). Autonomic regulation of systemic inflammation in humans: a multi-center,
blinded observational cohort study., Editors: Kelley K. Elsevier Brain, Behavior, and Immunity
Karmali SN, Sciusco A, May SM and Ackland GL (2017). Heart rate variability in critical care medicine: a systematic review. Springer Nature Intensive Care Medicine Experimental vol. 5, (1)
ABBOTT T, pearse R, ahmad T and ackland G (2017). Association between preoperative pulse pressure and perioperative myocardial injury: an international observational cohort study of patients undergoing non-cardiac surgery. OUP British Journal Of Anaesthesia vol. 119, (1) 78-86.
ABBOTT T, Lee A, Pearse R, Ackland G and Minto G (2017). Elevated preoperative heart rate is associated with cardiopulmonary and autonomic impairment in high-risk surgical patients. OUP British Journal Of Anaesthesia vol. 119, (1) 87-94.
Machhada A, Trapp S, Marina N, Stephens RCM, Whittle J, Lythgoe MF, Kasparov S, Ackland GL and Gourine AV (2017). Vagal determinants of exercise capacity. Springer Nature Nature Communications vol. 8, (1)
Biccard BM, Scott DJA, Chan MTV, Archbold A, Wang C-Y, Sigamani A, Urrútia G, Cruz P, Srinathan SK, Szalay D, Harlock J, Tittley JG, Rapanos T, Elias F, Jacka MJ, Malaga G, Abraham V, Berwanger O, Montes FR, Heels-Ansdell DM, Hutcherson MT, Chow CK, Polanczyk CA, Szczeklik W, Ackland GL, Dubois L, Sapsford RJ, Williams C, Cortés OL and Le Mananch Y (2017). Myocardial Injury After Noncardiac Surgery (MINS) in Vascular Surgical Patients: A Prospective Observational Cohort Study. Ann Surg
Writing Committee for the VISION Study Investigators , Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M, Abraham V, Pearse R, Wang CY, Sessler DI, Kurz A, Szczeklik W, Berwanger O, Villar JC, Malaga G, Garg AX, Chow CK, Ackland G, Patel A, Borges FK, Belley-Cote EP, Duceppe E, Spence J, Tandon V, Williams C, Sapsford RJ, Polanczyk CA and Tiboni M (2017). Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery. JAMA vol. 317, (16) 1642-1651.
O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM and Prowle JR (2017). Acute kidney injury and mortality 1 year after major non-cardiac surgery. Wiley British Journal of Surgery
Patel A, Prowle JR, Ackland GL and Investigators P-OS (2017). Postoperative goal-directed therapy and development of acute kidney injury following major elective noncardiac surgery: post-hoc analysis of POM-O randomized controlled trial. Oxford University Press (OUP) Clinical Kidney Journal vol. 10, (3) 348-356.
Basalay M, Mastitskaya S, Mrochek A, Ackland GL, Arroyo AGD, Sanchez J, Sjoquist P-O, Pernow J, Gourine AV and Gourine A (2017). Reply: Glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning. Cardiovasc Res vol. 113, (1) 13-14.
2016
Turovsky E, Theparambil SM, Kasymov V, Deitmer JW, del Arroyo AG, Ackland GL, Corneveaux JJ, Allen AN, Huentelman MJ, Kasparov S, Marina N and Gourine AV (2016). Mechanisms of CO2/H+ Sensitivity of Astrocytes. Society for Neuroscience Journal of Neuroscience vol. 36, (42) 10750-10758.
Basalay MV, Mastitskaya S, Mrochek A, Ackland GL, del Arroyo AG, Sanchez J, Sjoquist P-O, Pernow J, Gourine AV and Gourine A (2016). Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning. Oxford University Press (OUP) Cardiovascular Research vol. 112, (3) 669-676.
Toner A, Jenkins N and Ackland GL (2016). Baroreflex impairment and morbidity after major surgery., Editors: Myles PS. Oxford University Press (OUP): Policy B - Oxford Open Option B British Journal of Anaesthesia vol. 117, (3) 324-331.
Ackland GL, Whittle J, Toner A, Machhada A, Del Arroyo AG, Sciuso A, Jenkins N, Dyson A, Struthers R, Sneyd JR, Minto G, Singer M, Shah AM and Gourine AV (2016). Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. Crit Care Med vol. 44, (8) e614-e624.
Abbott TEF, Ackland GL, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E, Rodseth RN, Devereaux PJ and Pearse RM (2016). Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study., Editors: Hemmings HC. British Journal of Anaesthesia vol. 117, (2) 172-181.
Ackland GL and Stephens RCM (2016). Big Data: A Cheerleader for Translational Perioperative Medicine. Anesth Analg vol. 122, (6) 1744-1747.
Sultan P, David AL, Fernando R and Ackland GL (2016). Inflammation and Epidural-Related Maternal Fever. Anesthesia & Analgesia vol. 122, (5) 1546-1553.
Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Croal BL, Granton JT, Thorpe KE, Grocott MPW, Farrington C, Myles PS, Cuthbertson BH and Investigators METSS (2016). Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery. BMJ Open vol. 6, (3) e010359-e010359.
Nelson A, Otto J, Whittle J, Stephens RCM, Martin DS, Prowle JR and Ackland GL (2016). Subclinical cardiopulmonary dysfunction in stage 3 chronic kidney disease. BMJ Open Heart vol. 3, (1)
Marina N, Kasymov V, Ackland GL, Kasparov S and Gourine AV (2016). Astrocytes and Brain Hypoxia. Springer Nature Advances in Experimental Medicine and Biology vol. 903, 201-207.
2015
Patel ABU, Reyes A and Ackland GL (2015). Non-inferiority of retrospective data collection for assessing perioperative morbidity. PeerJ PeerJ vol. 3,
Abbott T, Ackland GL, Wragg A, Rodseth R, Archbold A and Pearse RM (2015). Association between intraoperative heart rate and postoperative myocardial injury in patients following non-cardiac surgery. Intensive Care Med Exp vol. 3, (Suppl 1) A751-A751.
Whittle J, Nelson A, Otto JM, Stephens RCM, Martin DS, Sneyd JR, Struthers R, Minto G and Ackland GL (2015). Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis. BMJ Open Heart vol. 2, (1)
Karmali S, Jenkins N, Sciusco A, John J, Haddad F, Ackland GL and Investigators P-XS (2015). Randomized controlled trial of vagal modulation by sham feeding in elective non-gastrointestinal (orthopaedic) surgery. Elsevier British Journal of Anaesthesia vol. 115, (5) 727-735.
Machhada A, Gourine AV and Ackland GL (2015). Vagal Modulation of Atrial Fibrillation. Elsevier Journal of the American College of Cardiology vol. 66, (8) 977-978.
Angelova PR, Kasymov V, Christie I, Sheikhbahaei S, Turovsky E, Marina N, Korsak A, Zwicker J, Teschemacher AG, Ackland GL, Funk GD, Kasparov S, Abramov AY and Gourine AV (2015). Functional Oxygen Sensitivity of Astrocytes. Society for Neuroscience Journal of Neuroscience vol. 35, (29) 10460-10473.
Edwards MR, Sultan P, del Arroyo AG, Whittle J, Karmali SN, Moonesinghe SR, Haddad FS, Mythen MG, Singer M and Ackland GL (2015). Metabolic dysfunction in lymphocytes promotes postoperative morbidity. Portland Press Clinical Science vol. 129, (5) 423-437.
Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A, Marina N and Gourine AV (2015). Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Elsevier Heart Rhythm vol. 12, (11) 2285-2293.
Milne A, Mon WY, Down J, Obichere A and Ackland GL (2015). Contemporary Perioperative Management of Adult Familial Dysautonomia (Riley-Day Syndrome). Wolters Kluwer A & A Case Reports vol. 4, (9) 111-113.
Ackland GL, Cecconi M and Pearse RM (2015). Individualised targeted haemodynamic therapy in high-risk surgical patients - authors' reply. Elsevier The Lancet. Respiratory medicine vol. 3, (4) e14-e15.
Ackland GL and Prowle JR (2015). Presepsin: solving a soluble (CD14) problem in sepsis? Springer Nature Intensive Care Medicine vol. 41, (2) 351-353.
Cain DJ, del Arroyo AG and Ackland GL (2015). Man is the new mouse: Elective surgery as a key translational model for multi-organ dysfunction and sepsis. SAGE Publications Journal of the Intensive Care Society vol. 16, (2) 154-163.
Ackland GL (2015). Heart Failure and Perioperative Care. Wolters Kluwer ASA Refresher Courses in Anesthesiology vol. 43, (1) 7-14.
2014
Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S, Whittle J, Reyes A, Singer M, Hamilton M, Cecconi M, Pearse RM, Mallett SV, Omar RZ and group FTP-OS (2014). Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial. Elsevier The Lancet Respiratory Medicine vol. 3, (1) 33-41.
Barsukevich V, Basalay M, Sanchez J, Mrochek A, Whittle J, Ackland GL, Gourine AV and Gourine A (2014). Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning. Springer Nature Basic Research in Cardiology vol. 110, (1)
Ackland GL and Laing CM (2014). Chronic kidney disease: a gateway for perioperative medicine. Elsevier British Journal of Anaesthesia vol. 113, (6) 902-905.
Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MPW, Ahern A, Griggs K, Scott R, Hinds C and Rowan K (2014). Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review. American Medical Association (AMA) JAMA vol. 311, (21) 2181-2190.
Botto F, Alonso-Coello P, Chan MTV, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G and Walsh M (2014). Myocardial Injury after Noncardiac Surgery. Wolters Kluwer Anesthesiology vol. 120, (3) 564-578.
Cain DJ, del Arroyo AG and Ackland GL (2014). Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine. Springer Nature Intensive Care Medicine Experimental vol. 2, (1)
Henderson WR, Barnbrook J, Dominelli PB, Griesdale DE, Arndt T, Molgat-Seon Y, Foster G, Ackland GL, Xu J, Ayas NT and Sheel AW (2014). Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome. Springer Nature Intensive Care Medicine Experimental vol. 2, (1)
Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ and O'Dwyer MJ (2014). Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study. Crit Care vol. 18, (5) 014-0541.
Sultan P, Edwards MR, del Arroyo AG, Cain D, Sneyd JR, Struthers R, Minto G and Ackland GL (2014). Cardiopulmonary Exercise Capacity and Preoperative Markers of Inflammation. Hindawi Mediators of Inflammation vol. 2014, (1)
Abbott T and Ackland GL (2014). The relationships between anesthesia, hemodynamics and outcome. Perioperative Hemodynamic Monitoring and Goal Directed Therapy Cambridge University Press (CUP)
2013
Ackland GL, Kazymov V, Marina N, Singer M and Gourine AV (2013). Peripheral Neural Detection of Danger–Associated and Pathogen–Associated Molecular Patterns. Wolters Kluwer Critical Care Medicine vol. 41, (6) e85-e92.
Toner A, Whittle J and Ackland GL (2013). Autonomic Dysfunction Is the Motor of Chronic Critical Illness. Annual Update in Intensive Care and Emergency Medicine 2013 Springer Nature
2012
Pearse and Ackland (2012). Perioperative fluid therapy. Hogrefe Publishing Group Praxis vol. 101, (17) 1113-1118.
Mastitskaya S, Marina N, Gourine A, Gilbey MP, Spyer KM, Teschemacher AG, Kasparov S, Trapp S, Ackland GL and Gourine AV (2012). Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones. Oxford University Press (OUP) Cardiovascular Research vol. 95, (4) 487-494.
Basalay M, Barsukevich V, Mastitskaya S, Mrochek A, Pernow J, Sjöquist P, Ackland GL, Gourine AV and Gourine A (2012). Remote ischaemic pre‐ and delayed postconditioning – similar degree of cardioprotection but distinct mechanisms. Wiley Quarterly Journal of Experimental Physiology and Cognate Medical Sciences vol. 97, (8) 908-917.
Pearse RM and Ackland GL (2012). Perioperative fluid therapy. BMJ The BMJ vol. 344, (apr26 1)
Dyson A, Cone S, Singer M and Ackland GL (2012). Microvascular and macrovascular flow are uncoupled in early polymicrobial sepsis. Elsevier British Journal of Anaesthesia vol. 108, (6) 973-978.
Ackland GL (2012). In Response. Wolters Kluwer Anesthesia & Analgesia vol. 114, (3)
Sultan P, Hamilton MA and Ackland GL (2012). Preoperative muscle weakness as defined by handgrip strength and postoperative outcomes: a systematic review. Springer Nature BMC Anesthesiology vol. 12, (1)
2011
Ackland GL, Moran N, Cone S, Grocott MPW and Mythen MG (2011). Chronic Kidney Disease and Postoperative Morbidity After Elective Orthopedic Surgery. Wolters Kluwer Survey of Anesthesiology vol. 55, (6) 287-288.
Holm L, Ackland GL, Edwards MR, Breckenridge RA, Sim RB and Offer J (2011). Chemical labelling of active serum thioester proteins for quantification. Elsevier Immunobiology vol. 217, (2) 256-264.
Ackland GL (2011). Reply from the authors. Elsevier British Journal of Anaesthesia vol. 106, (5)
Edwards M, Whittle J and Ackland GL (2011). Biomarkers to guide perioperative management. Oxford University Press (OUP) Postgraduate Medical Journal vol. 87, (1030) 542-549.
Cross J, Edwards M, Harrison S, Richards T and Ackland G (2011). Morbidity following complex EVAR. Wolters Kluwer International Journal of Surgery vol. 9, (7)
2010
Ackland GL, Dyson A and Singer M (2010). Arterial Hyperoxia and In-Hospital Mortality After Resuscitation From Cardiac Arrest. American Medical Association (AMA) JAMA vol. 304, (13) 1440-1441.
Ackland GL, Harris S, Ziabari Y, Grocott M, Mythen M and Investigators S (2010). Revised cardiac risk index and postoperative morbidity after elective orthopaedic surgery: a prospective cohort study. Elsevier British Journal of Anaesthesia vol. 105, (6) 744-752.
Barnes SJ and Ackland GL (2010). Beta-adrenoreceptor modulation of metabolic, endocrine and immunologic function during critical illness. Bentham Science Publishers Endocrine Metabolic & Immune Disorders - Drug Targets vol. 10, (3) 292-300.
Ackland GL, Moran N, Cone S, Grocott MPW and Mythen MG (2010). Chronic Kidney Disease and Postoperative Morbidity After Elective Orthopedic Surgery. Wolters Kluwer Anesthesia & Analgesia vol. 112, (6) 1375-1381.
Ackland GL and Edwards M (2010). Defining higher-risk surgery. Wolters Kluwer Current Opinion in Critical Care vol. 16, (4) 339-346.
Ackland GL, Del Arroyo AG, Yao ST, Stephens RC, Dyson A, Klein NJ, Singer M and Gourine AV (2010). Low-molecular-weight polyethylene glycol improves survival in experimental sepsis*. Wolters Kluwer Critical Care Medicine vol. 38, (2) 629-636.
Ackland GL, Yao ST, Rudiger A, Dyson A, Stidwill R, Poputnikov D, Singer M and Gourine AV (2010). Cardioprotection, attenuated systemic inflammation, and survival benefit of β1-adrenoceptor blockade in severe sepsis in rats*. Wolters Kluwer Critical Care Medicine vol. 38, (2) 388-394.
2009
Paschalis A, Churchill L, Marina N, Kasymov V, Gourine A and Ackland G (2009). β1-Adrenoceptor distribution in the rat brain: An immunohistochemical study. Elsevier Neuroscience Letters vol. 458, (2) 84-88.
Ackland GL and Patterson AJ (2009). The Pivotal Role of Beta-adrenoreceptors in Critical Illness Pathophysiology. Intensive Care Medicine Springer Nature
Ackland G, Agrawal R, Hou C and Patterson A (2009). Strain-specific and pathogen-specific physiologic and genomic differences in murine inflammatory cardiac dysfunction. Springer Nature Critical Care vol. 13, (Suppl 1)
2008
Ackland GL, O’Beirne J, Platts AR and Ward SC (2008). False-Positive Presentation of Battle’s Sign During Hepatic Encephalopathy. Springer Nature Neurocritical Care vol. 9, (2)
Ackland GL, Harrington J, Downie P, Holding JW, Singh-Ranger D, Griva K, Mythen MG and Newman SP (2008). Dehydration Induced by Bowel Preparation in Older Adults Does Not Result in Cognitive Dysfunction. Wolters Kluwer Anesthesia & Analgesia vol. 106, (3) 924-929.
2007
Ackland GL, Kasymov V and Gourine AV (2007). Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing. Portland Press Biochemical Society Transactions vol. 35, (5) 1264-1268.
Ackland GL, Scollay JM, Parks RW, De Beaux I and Mythen MG (2007). Pre‐operative high sensitivity C‐reactive protein and postoperative outcome in patients undergoing elective orthopaedic surgery. Wiley Anaesthesia vol. 62, (9) 888-894.
Ackland GL, Smith M and McGlennan AP (2007). Acute, Severe Hypoglycemia Occurring During General Anesthesia in a Nondiabetic Adult. Wolters Kluwer Anesthesia & Analgesia vol. 105, (2) 553-554.
Ackland GL and Mythen MG (2007). Novel biomarkers in critical care: utility or futility? Springer Nature Critical Care vol. 11, (6)
2006
Ackland G and Mythen M (2006). Physiology of the Gastrointestinal Tract Including Splanchnic Blood Flow and Tonometry. Gastrointestinal and Colorectal Anesthesia Taylor & Francis
Ackland G (2006). Perioperative beta-blockade: beyond myocardial ischaemia. Mark Allen Group British Journal of Hospital Medicine vol. 67, (5) 276-276.
Hamilton MA, Mythen MG and Ackland GL (2006). Less Is Not More: A Lack of Evidence for Intraoperative Fluid Restriction Improving Outcome After Major Elective Gastrointestinal Surgery. Wolters Kluwer Anesthesia & Analgesia vol. 102, (3) 970-971.
Spyer KM, Ackland GL and Gourine AV (2006). NEUROPHYSIOLOGY | Overview. Encyclopedia of Respiratory Medicine Elsevier
Spyer KM, Ackland GL and Gourine AV (2006). NEUROPHYSIOLOGY. Encyclopedia of Respiratory Medicine: Volume 1-4
2005
Ackland GL and Fox R (2005). Low-dose Propofol Infusion for Controlling Acute Hyperspasticity after Withdrawal of Intrathecal Baclofen Therapy. Wolters Kluwer Anesthesiology vol. 103, (3) 663-665.
Ackland GL and Mythen MG (2005). Negative Pressure Pulmonary Edema as an Unsuspected Imitator of Acute Lung Injury/ARDS. Elsevier CHEST Journal vol. 127, (5) 1867-1868.
2004
Ackland GL, Singh-Ranger D, Fox S, McClaskey B, Down JF, Farrar D, Sivaloganathan M and Mythen MG (2004). Assessment of preoperative fluid depletion using bioimpedance analysis. Elsevier British Journal of Anaesthesia vol. 92, (1) 134-136.
2002
Ackland G (2002). Effect of low‐dose volatile anaesthetics on ventilation during acute hypoxia. Wiley Anaesthesia vol. 57, (12) 1224-1226.
2001
Ackland G (2001). Physical incompatibility between atracurium and intravenous diclofenac. Wiley Anaesthesia vol. 56, (3) 294-294.
2000
Ackland G, Grocott MP and Mythen MG (2000). Understanding gastrointestinal perfusion in critical care: so near, and yet so far. Springer Nature Critical Care vol. 4, (5)
1997
Ackland GL, Noble R and Hanson MA (1997). Red nucleus inhibits breathing during hypoxia in neonates1Paper presented at the conference of Neural Control of Breathing: Molecular to Organismal Perspectives, Madison, WI, 21–25 July 1996.1. Elsevier Respiratory Physiology & Neurobiology vol. 110, (2-3) 251-260.
1996
Moore PJ, Ackland GL and Hanson MA (1996). Unilateral cooling in the region of locus coeruleus blocks the fall in respiratory output during hypoxia in anaesthetized neonatal sheep. Wiley Quarterly Journal of Experimental Physiology and Cognate Medical Sciences vol. 81, (6) 983-994.
Waites BA, Ackland GL, Noble R and Hanson MA (1996). Red nucleus lesions abolish the biphasic respiratory response to isocapnic hypoxia in decerebrate young rabbits. Wiley The Journal of Physiology vol. 495, (1) 217-225.
1994
Ackland GL, Moore PJ and Hanson MA (1994). Is the Ventilatory Decline Seen in Newborns during Hypoxaemia Centrally Mediated? Springer Nature Advances in Experimental Medicine and Biology vol. 360, 345-348.
1992
THOMAS JM, MACKRODT WC and ACKLAND G (1992). CLASSICAL AND QUANTUM SIMULATION OF THE SURFACE-PROPERTIES OF ALPHA-AL2O3 - DISCUSSION. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES vol. 341, (1661) 312-312.
Grants
GlucoVITAL- Efficacy and Mechanism Evaluation Programme
Gareth Ackland and Sian Henson
£325,612 NIHR National Institute for Health Research (01-06-2023 - 31-05-2025)
Gareth Ackland and Sian Henson
£325,612 NIHR National Institute for Health Research (01-06-2023 - 31-05-2025)
Gareth Ackland - NIHR advanced fellowship (FUNNY)
Gareth Ackland
£1,138,183 NIHR National Institute for Health Research (01-06-2020 - 31-12-2025)
Gareth Ackland
£1,138,183 NIHR National Institute for Health Research (01-06-2020 - 31-12-2025)
EPIFEVER - personalised genomic medicine to guide labour analgesia
Gareth Ackland
£59,782 OAA Obstetric Anaesthesia Association (01-03-2020 - 31-12-2023)
Gareth Ackland
£59,782 OAA Obstetric Anaesthesia Association (01-03-2020 - 31-12-2023)
Cardic Vagus and Exercise in Health Disease
Gareth Ackland and Andrew Tinker
£429,815 BHF British Heart Foundation (01-12-2019 - 30-11-2024)
Gareth Ackland and Andrew Tinker
£429,815 BHF British Heart Foundation (01-12-2019 - 30-11-2024)
Brainstem vagal dysfunction after critical illness
Gareth Ackland
£3,978 Barts and the London Charity (01-09-2019 - 31-08-2022)
Gareth Ackland
£3,978 Barts and the London Charity (01-09-2019 - 31-08-2022)