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Prof Qingzhong Xiao

Qingzhong Xiao

Professor of Stem Cell and Cardiovascular Disease

William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London

www.qmul.ac.uk/whri/people/academic-staff/items/xiao-qingzhong-.html

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Pu X, Chan K, Yang W, Xiao Q, Zhang L, Moore AD, Liu C, Webb TR, Caulfield MJ, Samani NJ, Zhu J and Ye S (2020). Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis. Atherosclerosis  vol. 296, 11-17. 10.1016/j.atherosclerosis.2020.01.015
Maguire EM and Xiao Q (2020). Noncoding RNAs in vascular smooth muscle cell function and neointimal hyperplasia. Febs Journal  10.1111/febs.15357

2019

Maguire EM, Pearce SWA, Xiao R, Oo AY and Xiao Q (2019). Matrix metalloproteinase in abdominal aortic aneurysm and aortic dissection. Pharmaceuticals  vol. 12, (3) 10.3390/ph12030118
Yang F, Chen Q, Yang M, Maguire EM, Yu X, He S, Xiao R, Wang CS, An W, Wu W, Zhou Y, Xiao Q and Zhang L (2019). Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia. Cardiovasc Res  10.1093/cvr/cvz044
Liu SS, Maguire EM, Bai YS, Huang L, Liu Y, Xu L, Fauzi I, Zhang SQ, Xiao Q and Ma NF (2019). A novel regulatory axis, CHD1L-MicroRNA 486-matrix metalloproteinase 2, controls spermatogonial stem cell properties. Molecular and Cellular Biology  vol. 39, (4) 10.1128/MCB.00357-18
Maguire EM, Pearce SWA and Xiao Q (2019). Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease. Vascular Pharmacology  vol. 112, 54-71. 10.1016/j.vph.2018.08.002

2018

Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P, Pellegatta F, Grigore L, Da Dalt L, Annoni A, Gregori S, Xiao Q, Caruso D, Mitro N, Catapano AL, Marelli-Berg FM and Norata GD (2018). Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation. Nature Communications  vol. 9, (1) 10.1038/s41467-018-05322-1
Chen Q, Wang Q, Zhu J, Xiao Q and Zhang L (2018). Reactive oxygen species: key regulators in vascular health and diseases. British Journal of Pharmacology  vol. 175, (8) 1279-1292. 10.1111/bph.13828
Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M, Zhang L, Ye S, Nourshargh S and Xiao Q (2018). Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis. J Am Heart Assoc  vol. 7, (4) 10.1161/JAHA.117.008187
Yang F, Chen Q, He S, Yang M, Maguire EM, An W, Afzal TA, Luong LA, Zhang L and Xiao Q (2018). miR-22 is a novel mediator of vascular smooth muscle cell phenotypic modulation and neointima formation. Circulation  vol. 137, (17) 1824-1841. 10.1161/CIRCULATIONAHA.117.027799
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S and Caulfield MJ (2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Human Molecular Genetics  vol. 27, (1) 199-210. 10.1093/hmg/ddx375

2017

Zhang C, Chen D, Margaret Maguire E, He S, Chen J, An W, Yang M, Adeel Afzal T, Anh Luong L, Zhang L, Lei H, Wu Q and Xiao Q (2017). Cbx3 Inhibits Vascular Smooth Muscle Cell Proliferation, Migration and Neointima Formation. Oxford University Press (Oup)  Cardiovascular Research  10.1093/cvr/cvx236
Zhang L, Chen Q, An W, Yang F, Maguire EM, Chen D, Zhang C, Wen G, Yang M, Dai B, Luong LA, Zhu J, Xu Q and Xiao Q (2017). Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia. American Heart Association/American Stroke Association  Arterioscler Thromb Vasc Biol  vol. 37, (11) 2182-2194. 10.1161/ATVBAHA.117.310020
AHLUWALIA A (2017). The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque. National Academy of Sciences  Proceedings of The National Academy of Sciences of Usa  10.1073/pnas.1613063114
Maguire EM, Xiao Q and Xu Q (2017). Differentiation and application of induced pluripotent stem cell?derived vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 37, (11) 2026-2037. 10.1161/ATVBAHA.117.309196

2016

Afzal TA, Luong LA, Chen D, Zhang C, Yang F, Chen Q, An W, Wilkes E, Yashiro K, Cutillas PR, Zhang L and Xiao Q (2016). NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia. Wiley  Journal of The American Heart Association  vol. 5, (12) e004629-e004629. 10.1161/JAHA.116.004629
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield MJ (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. J Hypertens  vol. 34 Suppl 2, 10.1097/01.hjh.0000491573.57396.0f
Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R, Wu J, Yan S, Situ H, He X, Chen Y, Tan X, Xiao Q, Tucker AT, Caulfield MJ and Ye S (2016). Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction., Editors: Humphries SE. Public Library of Science  Plos Genetics  vol. 12, (7) e1006127-e1006127. 10.1371/journal.pgen.1006127
Yang F, Chen Q, Wen G, Zhang C, Luong LA, Zhu J, Zhang L and Xiao Q (2016). FUNCTIONAL ROLE OF miRNA-34A IN SMOOTH MUSCLE CELL FUNCTIONS AND NEOINTIMA FORMATION. Atherosclerosis  vol. 244, E3-E4. 10.1016/j.atherosclerosis.2015.10.060

2015

Chen Q, Yang F, Guo M, Wen G, Zhang C, Luong LA, Zhu J, Xiao Q and Zhang L (2015). miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration. Journal of Molecular and Cellular Cardiology  vol. 89, 75-86. 10.1016/j.yjmcc.2015.10.017
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. Journal of Human Hypertension  vol. 29, (10) 624-624.
Wen G, Zhang C, Chen Q, Luong LA, Mustafa A, Ye S and Xiao Q (2015). A novel role of matrix metalloproteinase-8 in macrophage differentiation and polarization. Journal of Biological Chemistry  vol. 290, (31) 19158-19172. 10.1074/jbc.M114.634022
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J, Ye S, Xu Q, Wang W and Xiao Q (2015). Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Cell Death and Differentiation  vol. 22, (7) 1170-1180. 10.1038/cdd.2014.206
Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong LA, Zhu J, Shu Y, Zhang L and Xiao Q (2015). MicroRNA-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells by Targeting Methyl CpG-Binding Protein 2. Arteriosclerosis Thrombosis and Vascular Biology  vol. 35, (4) 918-929. 10.1161/ATVBAHA.114.305212
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y and Xu Q (2015). XBP 1-deficiency abrogates neointimal lesion of injured vessels via cross talk with the PDGF signaling. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 35, (10) 2134-2144. 10.1161/ATVBAHA.115.305420

2014

Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J, Ye S, Xu Q, Wang W and Xiao Q (2014). Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Nature Publishing Group  Cell Death and Differentiation  10.1038/cdd.2014.206
Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q and Ye S (2014). Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation. Arterioscler Thromb Vasc Biol  vol. 34, (1) 90-98. 10.1161/ATVBAHA.113.301418

2013

Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z, Yin X, Mayr M, Cockerill G, Li JY-S, Chien S and Hu Y (2013). Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2. J Biol Chem  vol. 288, (44) 31853-31866. 10.1074/jbc.M113.463745
Luo Z, Wen G, Wang G, Pu X, Ye S, Xu Q, Wang W and Xiao Q (2013). MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1. Stem Cells  vol. 31, (9) 1749-1762. 10.1002/stem.1448
Chen Q, Jin M, Yang F, Zhu J, Xiao Q and Zhang L (2013). Matrix metalloproteinases: Inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators of Inflammation  vol. 2013, 10.1155/2013/928315
Fang C, Wen G, Zhang L, Lin L, Moore A, Wu S, Ye S and Xiao Q (2013). An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo. Cardiovasc Res  vol. 99, (1) 146-155. 10.1093/cvr/cvt060
Huang Y, Lin L, Yu X, Wen G, Pu X, Zhao H, Fang C, Zhu J, Ye S, Zhang L and Xiao Q (2013). Functional involvements of heterogeneous nuclear ribonucleoprotein A1 in smooth muscle differentiation from stem cells in vitro and in vivo. Stem Cells  vol. 31, (5) 906-917. 10.1002/stem.1324
Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J, Wang W, Cockerill G, Mori K, Yi-Shuan Li J, Chien S, Hu Y and Xu Q (2013). Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation  vol. 127, (16) 1712-1722. 10.1161/CIRCULATIONAHA.112.001337
Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ and Ye S (2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. Am J Hum Genet  vol. 92, (3) 366-374. 10.1016/j.ajhg.2013.01.012
Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ and Ye S (2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. American Journal of Human Genetics  vol. 92, (3) 366-374. 10.1016/j.ajhg.2013.01.012
Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q and Zeng L (2013). XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. Journal of Biological Chemistry  vol. 288, (2) 859-872. 10.1074/jbc.M112.412783
Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q and Ye S (2013). Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions. Circ Res  vol. 112, (1) 35-47. 10.1161/CIRCRESAHA.112.274019
Zheng X, Wu Y, Zhu L, Chen Q, Zhou Y, Yan H, Chen T, Xiao Q, Zhu J and Zhang L (2013). Angiotensin II promotes differentiation of mouse embryonic stem cells to smooth muscle cells through PI3-kinase signaling pathway and NF-κB. Differentiation  vol. 85, (1-2) 41-54. 10.1016/j.diff.2012.11.003
Zhou Y, Yan H, Guo M, Zhu J, Xiao Q and Zhang L (2013). Reactive Oxygen Species in Vascular Formation and Development. Oxidative Medicine and Cellular Longevity  vol. 2013, 10.1155/2013/374963
Chen Q, Jin M, Zhu J, Xiao Q and Zhang L (2013). Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation. Biomed Research International  10.1155/2013/623978

2012

Huang Y, Lin L, Yu X, Pu X, Zhu J, Zhang L, Ye S and Xiao Q (2012). Functional Involvements of Heterogeneous Nuclear Ribonucleoprotein A1 in Smooth Muscle Differentiation from Stem Cells in vitro and in vivo. Circulation  vol. 126, (21)
Zhang L, Zheng X, Wu Y, Chen Q, Zhu J and Xiao Q (2012). Microrna-34a Regulates Smooth Muscle Cell Differentiation from Stem Cells by 'Targeting Sirtnin 1. Circulation  vol. 126, (21)
Luo Z, Wen G, Wang G, Pu X, Wang W, Ye S, Xu Q and Xiao Q (2012). Microrna-200c and-150 Play a Role in Human Embryonic Stem Cell Differentiation Into Endothelial Cells and Blood Vessel Formation by Targeting Transcription Repressor Zebi. Circulation  vol. 126, (21)
Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q and Ye S (2012). Matrix Metalloproteinase-8 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation. Circulation  vol. 126, (21)
Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D, Zhang Z, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q and Ye S (2012). A Functional Role of Matrix Metalloproteinase-8 in Stem/progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions. Circulation  vol. 126, (21)
Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ and Ye S (2012). Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. Hum Mol Genet  vol. 21, (18) 4021-4029. 10.1093/hmg/dds224
Tsai TN, Kirton JP, Campagnolo P, Zhang L, Xiao Q, Zhang Z, Wang W, Hu Y and Xu Q (2012). Contribution of stem cells to neointimal formation of decellularized vessel grafts in a novel mouse model. American Journal of Pathology  vol. 181, (1) 362-373. 10.1016/j.ajpath.2012.03.021
Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y, Ye S and Xu Q (2012). Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells. Arterioscler Thromb Vasc Biol  vol. 32, (3) 730-744. 10.1161/ATVBAHA.111.243188
Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y, Ye S and Xu Q (2012). Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 32, (3) 730-744. 10.1161/ATVBAHA.111.243188
Liang Q-L, Liang X-P, Wang Y-M, Xie Y-Y, Zhang R-L, Chen X, Gao R, Cheng Y-J, Wu J, Xu Q-B, Xiao Q-Z, Li X, Lv S-F, Fan X-M, Zhang H-Y, Zhang Q-L and Luo G-A (2012). Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on system to system mode. Journal of Translational Medicine  vol. 10, 10.1186/1479-5876-10-26
Knoflach M, Kiechl S, Mantovani A, Cuccovillo I, Bottazzi B, Xu Q, Xiao Q, Gasperi A, Mayr A, Kehrer M, Willeit J and Wick G (2012). Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies. Plos One  vol. 7, (2) 10.1371/journal.pone.0031474
Motterle A, Xiao Q, Kiechl S, Pender SLF, Morris GE, Willeit J, Caulfield MJ and Ye S (2012). Influence of matrix metalloproteinase-12 on fibrinogen level. Atherosclerosis  vol. 220, (2) 351-354. 10.1016/j.atherosclerosis.2011.11.003
Wang G, Xiao Q, Luo Z, Ye S and Xu Q (2012). Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis. J Biol Chem  vol. 287, (4) 2896-2906. 10.1074/jbc.M111.297028
Wang G, Xiao Q, Luo Z, Ye S and Xu Q (2012). Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis. J Biol Chem.  vol. 287, (4) 2896-2906. 10.1074/jbc.M111.297028
Sims D and Xiao Q (2012). Smooth muscle cell differentiation from embryonic stem cells: Role of HDAC7 and PDGF-BB. Stem Cells and Cancer Stem Cells, Volume 4: Therapeutic Applications in Disease and Injury  10.1007/978-94-007-2828-8_7

2011

Kiechl S, Paré G, Barbalic M, Qi L, Dupuis J, Dehghan A, Bis JC, Laxton RC, Xiao Q, Bonora E, Willeit J, Xu Q, Witteman JCM, Chasman D, Tracy RP, Ballantyne CM, Ridker PM, Benjamin EJ and Ye S (2011). Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis. Circ Cardiovasc Genet  vol. 4, (6) 681-686. 10.1161/CIRCGENETICS.111.960682
Zhou B, Margariti A, Zeng L, Habi O, Xiao Q, Martin D, Wang G, Hu Y, Wang X and Xu Q (2011). Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation. Arterioscler Thromb Vasc Biol  vol. 31, (11) 2676-2684. 10.1161/ATVBAHA.111.230888
Luo Z, Xiao Q, Wang W and Xu Q (2011). DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TOWARDS THE ENDOTHELIAL LINEAGE INVOLVES MICRORNAS. Heart  vol. 97, (20) 4-4. 10.1136/heartjnl-2011-300920b.6
Wang G, Xiao Q and Xu Q (2011). STEM CELL DIFFERENTIATION TO SMOOTH MUSCLE CELLS IS REGULATED BY HNRNP A2/B1. Heart  vol. 97, (20) 3-4. 10.1136/heartjnl-2011-300920b.4
Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, Mayr M, Ye S and Xu Q (2011). Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis. Arterioscler Thromb Vasc Biol  vol. 31, (8) 1842-1852. 10.1161/ATVBAHA.111.230110
Luo ZL, Wang G, Wang W, Xiao QZ and Xu QB (2011). Signalling pathways that regulate endothelial differentiation from stem cells. Front Biosci-Landmrk  vol. 16, 472-485. 10.2741/3699
Kane NM, Xiao Q, Baker AH, Luo Z, Xu Q and Emanueli C (2011). Pluripotent Stem Cell Differentiation into Vascular Cells: A Novel Technology with Promises for Vascular Re(Generation). Pharmacol Ther.  vol. 129, (1) 29-49. 10.1016/j.pharmthera.2010.10.004
Xiao Q and Ye S (2011). The genetics of epigenetics: is there a link with cardiovascular disease. Heart  vol. 97, (2) 96-97. 10.1136/hrt.2010.214833

2010

Zhang L, Jin M, Margariti A, Wang G, Luo Z, Zampetaki A, Zeng L, Ye S, Zhu J and Xiao Q (2010). Sp1-dependent activation of HDAC7 is required for platelet-derived growth factor-BB-induced smooth muscle cell differentiation from stem cells. J Biol Chem  vol. 285, (49) 38463-38472. 10.1074/jbc.M110.153999
Kiechl S, Laxton RC, Xiao Q, Hernesniemi JA, Raitakari OT, Kähönen M, Mayosi BM, Jula A, Moilanen L, Willeit J, Watkins H, Samani NJ, Lehtimäki TJ, Keavney B, Xu Q and Ye S (2010). Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. Arterioscler Thromb Vasc Biol  vol. 30, (12) 2678-2683. 10.1161/ATVBAHA.110.213785
Zeng L, Xiao Q, Li H, Margariti A, Hu Y and Xu Q (2010). Xbp1 Splicing is Crucial in Endothelial Cell Proliferation. Circulation  vol. 122, (21)
Xiao Q, Pepe AE and Xu Q (2010). Pla2g7 is Crucial in Stem Cell Differentiation into Smooth Muscle Cells and Involves in Atherosclerosis. Circulation  vol. 122, (21)
Margariti A, Li H, Martin D, Xiao Q, Zampetaki A, Hu Y, Xu Q and Zeng L (2010). X-Box Binding Protein 1 Splicing Triggers an Autophagic Response-Mediated Survival in Endothelial Cells. Circulation  vol. 122, (21)
Dotsenko O, Xiao Q, Xu Q and Jahangiri M (2010). Bone Marrow Resident and Circulating Progenitor Cells in Patients Undergoing Cardiac Surgery. Annals of Thoracic Surgery  vol. 90, (6) 1944-1951. 10.1016/j.athoracsur.2010.08.033
Zhang L, Jin M, Margariti A, Wang G, Luo Z, Zampetaki A, Zeng L, Ye S, Zhu J and Xiao Q (2010). Sp1-dependent activation of HDAC7 is required for PDGF-BB-induced smooth muscle cell differentiation from stem cells. The Journal of Biological Chemistry  vol. 285, 38463-38472. 10.1074/jbc.M110.153999
xiao Q, Wang G, Luo Z and Xu Q (2010). The mechanism of stem cell differentiation into smooth muscle cells. Thromb Haemost  vol. 104, (3) 440-448. 10.1160/TH09-11-0794
Margariti A, Zampetaki A, Xiao Q, Zou B, Karamariti E, Martin D, Yin X, Mayr M, Li H and Zhang Z (2010). Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. Circ Res.  vol. 106, (7) 1202-1211. 10.1161/CIRCRESAHA.109.213165
Pepe AE, Xiao Q, Zampetaki A, Zhang Z, Kobayashi A, Hu Y and Xu Q (2010). Crucial role of nrf3 in smooth muscle cell differentiation from stem cells. Circ Res.  vol. 106, (5) 870-879. 10.1161/CIRCRESAHA.109.211417
Ye S, Willeit J, Xiao Q, Motterle A, Laxton RC, Oberhollenzer F, Kiechl S and Xu Q (2010). Single nucleotide polymorphism on chromosome 9p21 and endothelial progenitor cells in a general population cohort. Atherosclerosis  vol. 208, (2) 451-455. 10.1016/j.atherosclerosis.2009.08.006
Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung K-Y, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, Lopez-Otin C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q and Ye S (2010). A Role of Matrix Metalloproteinase-8 in Atherosclerosis (vol 105, pg 921, 2009). Circulation Research  vol. 106, (1) E1-E1. 10.1161/RES.0b013e3181cdee32
Zampetaki A, Zeng L, Margariti A, Xiao Q, Li H, Zhang Z, Pepe AE, Wang G, Habi O, deFalco E, Cockerill G, Mason JC, Hu Y and Xu Q (2010). Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation  vol. 121, (1) 132-142. 10.1161/CIRCULATIONAHA.109.890491

2009

Pepe AE, Xiao Q, Zampetaki A and Xu Q (2009). NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 3 MEDIATES STEM CELL DIFFERENTIATION INTO SMOOTH MUSCLE CELLS THROUGH INCREASED REACTIVE OXYGEN SPECIES GENERATION AND PLASMA PHOSPHOLIPASE A2 PRODUCTION. Heart  vol. 95, (22) 10.1136/hrt.2009.178137x
Xiao Q, Luo Z, Pepe A, Margariti A, Zeng L and Xu Q (2009). NADPH OXIDASE PRODUCED HYDROGEN PEROXIDE-MEDIATED SMOOTH MUSCLE CELL DIFFERENTIATION FROM STEM CELL. Heart  vol. 95, (22) 10.1136/hrt.2009.181669l
Mayr U, Pula G, Evans C, Prokopi M, Yin X, Xiao Q, Hill J, Xu Q and Mayr M (2009). PROTEOMICS IDENTIFIES THYMIDINE PHOSPHORYLASE AS A KEY REGULATOR OF THE ANGIOGENIC POTENTIAL OF COLONY FORMING UNITS AND ENDOTHELIAL PROGENITOR CELL CULTURES. Heart  vol. 95, (22) 10.1136/hrt.2009.178129g
Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung K-Y, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, López-Otín C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q and Ye S (2009). A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res  vol. 105, (9) 921-929. 10.1161/CIRCRESAHA.109.200279
Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C and Willeit J (2009). Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. Blood  vol. 114, (3) 723-732. 10.1136/hrt.2009.178137y
Dotsenko O, Xiao Q, Xu Q and Jahangiri M (2009). SEVERITY OF CORONARY ATHEROSCLEROSIS AND CARDIOPULMONARY BYPASS AFFECT STEM CELL TRAFFICKING FOLLOWING CARDIAC SURGERY. Atherosclerosis Supplements  vol. 10, (2)
Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin ZG and Cockerill G (2009). Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci U S a.  vol. 106, (20) 8326-8331.
Xiao Q and Xu Q (2009). Caspase-8, a double-edged sword for EPC functioning. Arterioscler Thromb Vasc Biol.  vol. 29, (4) 444-446. 10.1161/ATVBAHA.108.183087
Xiao Q, Luo Z, Pepe AE, Margariti A, Zeng L and Xu Q (2009). Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2. Am J Physiol Cell Physiol.  vol. 296, (4) C711-C723. 10.1152/ajpcell.00442.2008
Margariti A, Xiao Q, Zampetaki A, Zhang Z, Li H, Martin D, Hu Y, Zeng L and Xu Q (2009). Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells. J Cell Sci.  vol. 122, (4) 460-470. 10.1242/​jcs.034850
Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q, Hill J and Xu Q (2009). Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res.  vol. 104, (1) 32-40. 10.1161/CIRCRESAHA.108.182261
Xiao Q, Savvidou MD and Nicolaides KH (2009). Endothelial progenitor cells and pregnancy REPLY. American Journal of Obstetrics and Gynecology  vol. 200, (1) E19-E20. 10.1016/j.ajog.2008.06.042

2008

Xiao Q, Ye S, Oberhollenzer F, Mayr A, Jahangiri M, Willeit J, Kiechl S and Xu Q (2008). SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study. Plos One  vol. 3, (12)
Xiao Q, Zhang L, Luo Z, Pepe A, Margariti A, Zeng L and Xu Q (2008). Nox4 is Crucial for Stem Cell Differentiation into Smooth Muscle Cells. Circulation  vol. 118, (18) S411-S411.
Pula G, Mayr U, Evans C, Prokopi M, Xiao Q, Hill J, Xu Q and Mayr M (2008). Proteomics Identifies Thymidine Phosphorylase as a Key Regulator of the Angiogenic Potential of Endothelial Progenitor Cells. Circulation  vol. 118, (18) S412-S412.
Foteinos G, Hu Y, Xiao Q, Metzler B and Xu Q (2008). Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice. Circulation  vol. 117, (14) 1856-1863. 10.1161/​CIRCULATIONAHA.107.746008
Savvidou MD, Xiao Q, Kaihura C, Anderson JM and Nicolaides KH (2008). Maternal circulating endothelial progenitor cells in normal singleton and twin pregnancy. Am J Obstet Gynecol.  vol. 198, (4) 414.e1-414.e5. 10.1016/j.ajog.2007.10.800
Xiao Q, Ye S, Oberhollenzer F, Mayr A, Jahangiri M, Willeit J, Kiechl S and Xu Q (2008). SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study. Plos One  vol. 3, (12) 10.1371/journal.pone.0004061

2007

Adams B, Xiao Q and Xu Q (2007). Vascular progenitor cells and atherosclerosis. Future Cardiology  vol. 3, (6) 635-645. 10.2217/14796678.3.6.635
Qi XW, Liu HF, Xue YZ, Kong XQ, Xu QB and Xiao QZ (2007). Changes of endothelial progenitor cells and vascular endothelial growth factor in patients with coronary artery disease. Journal of Clinical Rehabilitative Tissue Engineering Research  vol. 11, (42) 8439-8443.
Xiao Q, Kiechl S, Patel S, Oberhollenzer F, Weger S, Mayr A, Metzler B, Reindl M, Hu Y, Willeit J and Xu Q (2007). Endothelial Progenitor Cells, Cardiovascular Risk Factors, Cytokine Levels and Atherosclerosis - Results from a Large Population-Based Study. Plos One  vol. 2, (10) 10.1371/journal.pone.0000975
Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q and Mayr M (2007). Integrated membrane protein analysis of mature and embryonic stem cell-derived smooth muscle cells using a novel combination of CyDye/biotin labeling. Mol Cell Proteomics  vol. 6, (10) 1788-1797. 10.1074/mcp.M600433-MCP200
Adams B, Xiao Q and Xu Q (2007). Stem cell therapy for vascular disease. Trends in Cardiovascular Medicine  vol. 17, (7) 246-251. 10.1016/j.tcm.2007.08.005
Zampetaki A, Zeng L, Xiao Q, Margariti A, Hu Y and Xu Q (2007). Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A. American Journal of Physiology-Cell Physiology  vol. 293, (4) C1226-C1238. 10.1152/ajpcell.00152.2007
Roberts N, Xiao Q, Weir G, Xu Q and Jahangiri M (2007). Endothelial Progenitor Cells are Mobilized After Cardiac Surgery. Annals of Thoracic Surgery  vol. 83, (2) 598-605. 10.1016/j.athoracsur.2006.09.087
Xiao Q, Zeng L, Zhang Z, Hu Y and Xu Q (2007). Stem cell-derived Sca-1+ progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin α1/ β1v and PDGF receptor pathways. American Journal of Physiology - Cell Physiology  vol. 292, (1) 10.1152/ajpcell.00341.2006

2006

Yin XK, Mayr M, Xiao QZ, Wang W and Xu QB (2006). Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells. Proteomics  vol. 6, (24) 6437-6446. 10.1002/pmic.200600351
Xiao Q, Zeng L, Zhang Z, Margariti A, Ali ZA, Channon KM, Xu Q and Hu Y (2006). Sca-1+ progenitors derived from embryonic stem cells differentiate into endothelial cells capable of vascular repair after arterial injury. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 26, (10) 2244-2251. 10.1161/01.ATV.0000240251.50215.50
Zeng L, Xiao Q, Margariti A, Zhang Z, Zampetaki A, Patel S, Capogrossi MC, Hu Y and Xu Q (2006). HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells. Journal of Cell Biology  vol. 174, (7) 1059-1069. 10.1083/jcb.200605113
Zampetaki A, Xiao Q, Zeng L, Hu Y and Xu Q (2006). TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications. Biochemical and Biophysical Research Communications  vol. 347, (1) 89-99. 10.1016/j.bbrc.2006.06.055

2005

XIAO Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Kiechl S and XU Q (2005). Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study. Lippincott Williams & Wilkins  Stroke  vol. 36, (12) 2571-2576. 10.1161/01.STR.0000189632.98944.ab
WANG W, Yin XK, Xu QB, Wait R, Mayr U, Mayr M, Xiao QZ and Tarelli E (2005). Proteomic dataset of Sca-1+ progenitor cells. Proteomics  vol. 5, (17) 4533-4545. 10.1002/pmic.200402044

Grants

Grants of specific relevance to Predictive in vitro Models
Neotrophil elastase (NE): A new player in atherosclerosis
Xiao Q
£84,000 Medical Research Council (01-10-2015 - 30-09-2018)
Abstract