Prof Rob Krams

Professor of Molecular Bioengineering

School of Engineering and Materials Science
Queen Mary University of London

07972 413211

r.krams@qmul.ac.uk

www.sems.qmul.ac.uk/staff/r.krams

Research
Publications
Grants

Research

Cardiovascular Models

Interests

Interested in evaluating miRNA as a new treatment for atherosclerosis. We predict (bioinformatics) and test (high throughput) new miRNA in animal models of atherosclerosis

Publications

2025

Effects of Trichomonas gallinae infection and diet on blood microbiome composition in european greenfinches (Chloris chloris)
Krama T, Krams R, Popovs S, Gudrā D, Ustinova M, Fridmanis D, Trakimas G, Contreras-Garduño J et al.
Frontiers in Physiology, Frontiers Media Sa vol. 16

DOI 10.3389/fphys.2025.1576833

05-06-2025

Ecological Trap Effects in Migratory European Pied Flycatchers (Ficedula hypoleuca) Nesting in Pest Outbreak-Affected Forests
Adams CB, Krams R, Elferts D, Brūmelis G, Dauškane I, Strode L, Šmits A, Trakimas G et al.
Birds, Mdpi Ag vol. 6 (2), 27-27.

DOI 10.3390/birds6020027

26-05-2025

Infestation levels of Aphomia sociella in bumblebees increase with proximity to apiaries and result in lower reproductive output and weaker immune response
Krams R, Grigorjeva T, Willow J, Popovs S, Munkevics M, Trakimas G, Contreras-Garduño J, de Souza AR et al.
Frontiers in Bee Science, Frontiers Media Sa vol. 3

DOI 10.3389/frbee.2025.1550560

10-04-2025

Non-lethal effects of predation risk enhance long-term memory in Drosophila melanogaster
Krama T, Krams R, Popovs S, Trakimas G, Adams CB, Freeberg TM, Jõers P, Contreras-Garduño J et al.
Behaviour, Walter De Gruyter Gmbh vol. 162 (3-4), 227-241.

DOI 10.1163/1568539x-bja10302

04-03-2025

Great Tit (Parus major) Nestlings Have Longer Telomeres in Old‐Growth Forests Than in Young Forests
Krams R, Cīrule D, Munkevics M, Popovs S, Jõers P, Contreras Garduño J, Krams IA, Krama T
Ecology and Evolution, Wiley vol. 15 (1)

DOI 10.1002/ece3.70823

01-01-2025

2024

Editorial: Computational modelling of cardiovascular hemodynamics and machine learning
Bourantas C, Torii R, Karabasov S, Krams R
Frontiers in Cardiovascular Medicine, Frontiers Media Sa vol. 11

DOI 10.3389/fcvm.2024.1355843

QMRO

22-02-2024

Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy
Savvopoulos F, Keeling MC, Carassiti D, Fogell NA, Patel MB, Naser J, Gavara N, de Silva R et al.
Journal of The Royal Society Interface, The Royal Society vol. 21 (211)

DOI 10.1098/rsif.2023.0674

QMRO

01-02-2024

2023

TCT-613 Comparison of Histology-Trained Deep Learning Approach With Human Expert Analysts for Automated Plaque Component Classification in Hybrid Intravascular Ultrasound-Optical Coherence Tomography Images
Bajaj R, Huang X, Alves-Kotzev N, Weyers J, Levine M, Garg M, Maung S, Bransby K et al.
Journal of The American College of Cardiology, Elsevier Bv vol. 82 (17), B246-B247.

DOI 10.1016/j.jacc.2023.09.624

QMRO

01-10-2023

A physics-based machine learning technique rapidly reconstructs the wall-shear stress and pressure fields in coronary arteries
Morgan B, Murali AR, Preston G, Sima YA, Marcelo Chamorro LA, Bourantas C, Torii R, Mathur A et al.
Frontiers in Cardiovascular Medicine, Frontiers Media Sa vol. 10

DOI 10.3389/fcvm.2023.1221541

QMRO

29-09-2023

Considering the Influence of Coronary Motion on Artery-Specific Biomechanics Using Fluid–Structure Interaction Simulation
Fogell NAT, Patel M, Yang P, Ruis RM, Garcia DB, Naser J, Savvopoulos F, Davies Taylor C et al.
Annals of Biomedical Engineering, Springer Science and Business Media Llc vol. 51 (9), 1950-1964.

DOI 10.1007/s10439-023-03214-0

QMRO

12-07-2023

BS12 A novel physics-based artificial intelligence technique rapidly reconstructs the 3D velocity, shear stress and pressure fields in coronary arteries.
Krams R, Preston G, Chamorro L, Morgan B, Sima Y, Murali A, Bourantas C, Torii R et al.
British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023.

DOI 10.1136/heartjnl-2023-bcs.226

QMRO

01-06-2023

BS15 Ultra-highly flexible, accurate, high throughput platform for knock-in studies.
Krams R, Herault S, Jaitly A, Bala R, Calistus A, Towhidi L
British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023.

DOI 10.1136/heartjnl-2023-bcs.229

01-06-2023

BS14 A fully automated vulnerable plaque classifier for oct using co-registered histological images and transfer learning learning.
Krams R, Chamorro L, Komo Z, Bashir A, Torii R, Bourantas C, Zhang Q, Mathur A et al.
British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023.

DOI 10.1136/heartjnl-2023-bcs.228

QMRO

01-06-2023

BS13 Ultra-highly flexible, accurate, high throughput platform for personalised drug screening studies.
Krams R, Towhidi L
British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023.

DOI 10.1136/heartjnl-2023-bcs.227

01-06-2023

Editorial: Computational modeling for assessing coronary artery pathophysiology
Çap M, Torii R, Onuma Y, Krams R, Bennett MR, Stone PH, Serruys PW, Bourantas CV
Frontiers in Cardiovascular Medicine, Frontiers Media Sa vol. 10

DOI 10.3389/fcvm.2023.1113835

QMRO

17-01-2023

2022

JAG1-NOTCH4 mechanosensing drives atherosclerosis
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 8 (35)

DOI 10.1126/sciadv.abo7958

QMRO

02-09-2022

TCT-254 Histology-Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images
Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K et al.
Journal of The American College of Cardiology, Elsevier Bv vol. 80 (12), B100-B100.

DOI 10.1016/j.jacc.2022.08.299

QMRO

01-09-2022

Histology- Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images
Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K et al.

QMRO

01-01-2022

2021

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis
Patel M, Savvopoulos F, Berggren CC, Aslanidou L, Timmins LH, de Silva R, Pedrigi RM, Krams R
Journal of Biomechanics, Elsevier Bv vol. 128, 110720-110720.

DOI 10.1016/j.jbiomech.2021.110720

QMRO

01-11-2021

Moving shear stress towards the clinic: preclinical comparison of optical coherence tomography-based versus angiography-based time-averaged wall shear stress estimations
Naser J, Fogell N, Patel M, Yang P, Krams R, Wentzel JJ, Aben JP, De Silva R
European Heart Journal, Oxford University Press (Oup) vol. 42 (Supplement_1)

DOI 10.1093/eurheartj/ehab724.1195

QMRO

12-10-2021

Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells
Herault S, Naser J, Carassiti D, Chooi KY, Nikolopoulou R, Font ML, Patel M, Pedrigi R et al.
Biophysical Reviews, Springer Science and Business Media Llc vol. 13 (5), 787-796.

DOI 10.1007/s12551-021-00839-0

QMRO

01-10-2021

Correction: BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model

Heart, Bmj vol. 107 (19), e10-e10.

DOI 10.1136/heartjnl-2021-bcs.216corr1

QMRO

14-09-2021

BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model
Naser J, Mein CA, Wozniak E, Carassiti D, Mahomed AS, Krams R, de Silva R
British Cardiovascular Society Virtual Annual Conference, ‘Cardiology and the Environment’, 7–10 June 2021.

DOI 10.1136/heartjnl-2021-bcs.216

QMRO

01-06-2021

2020

Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU et al.
Jacc: Cardiovascular Imaging, Elsevier Bv vol. 13 (10), 2206-2219.

DOI 10.1016/j.jcmg.2020.02.028

01-10-2020

3D co-registration algorithm for catheter-based optical coherence tomography
Post AL, Cernohorsky P, Pedrigi RM, Streekstra GJ, d’Hooghe JNS, Annema JT, Strackee SD, Krams R et al.
Osa Continuum, Optica Publishing Group vol. 3 (10), 2707-2707.

DOI 10.1364/osac.401599

17-09-2020

Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque
Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R et al.
Nanotheranostics, Ivyspring International Publisher vol. 4 (4), 184-194.

DOI 10.7150/ntno.44712

QMRO

01-01-2020

2019

Reliable in vivo intravascular imaging plaque characterization: A challenge unmet
Ramasamy A, Serruys PW, Jones DA, Johnson TW, Torii R, Madden SP, Amersey R, Krams R et al.
American Heart Journal, Elsevier Bv vol. 218, 20-31.

DOI 10.1016/j.ahj.2019.07.008

QMRO

01-12-2019

Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications
Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J et al.
European Heart Journal, Oxford University Press (Oup) vol. 40 (41), 3421-3433.

DOI 10.1093/eurheartj/ehz551

QMRO

30-09-2019

Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR et al.
Scientific Reports, Springer Science and Business Media Llc vol. 9 (1)

DOI 10.1038/s41598-019-40959-y

QMRO

18-03-2019

2018

Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis
Poulsen CB, Pedrigi RM, Pareek N, Kilic ID, Holm NR, Bentzon JF, Bøtker HE, Falk E et al.
Eurointervention, Europa Digital & Publishing vol. 14 (10), 1129-1135.

DOI 10.4244/eij-d-17-01028

QMRO

01-11-2018

P11 DEVELOPING NEW TARGETED MOLECULAR CONTRAST AGENTS FOR IMAGING INFLAMMATION OF VULNERABLE PLAQUES
Evans RJ, Hernández-Gil J, Mohri Z, Chooi KY, Lavin-Plaza B, Phinikaridou A, Pease JE, Krams R et al.

DOI 10.1093/cvr/cvy216.014

01-09-2018

P34 FLUID-STRUCTURE INTERACTION MODELLING FOR ANALYSING ADVANCED CORONARY ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC HYPERLIPIDAEMIC MINIPIGS
Yang P, Silva R, Pedrigi R, Patel M, Chooi Y, Ahmed R, Naser J, Krams R

DOI 10.1093/cvr/cvy216.037

01-09-2018

New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress
Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys C, Krams R
Current Opinion in Biomedical Engineering, Elsevier Bv vol. 5, 96-104.

DOI 10.1016/j.cobme.2018.03.003

01-03-2018

2017

Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis
Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 136 (12), 1140-1154.

DOI 10.1161/circulationaha.117.027844

QMRO

19-09-2017

The emerging role of YAP/TAZ in mechanotransduction
Mohri Z, Del Rio Hernandez A, Krams R
Journal of Thoracic Disease, Ame Publishing Company vol. 9 (5), E507-E509.

DOI 10.21037/jtd.2017.03.179

01-05-2017

Connexin40 controls endothelial activation by dampening NFκB activation
Denis J-F, Scheckenbach KEL, Pfenniger A, Meens MJ, Krams R, Miquerol L, Taffet S, Chanson M et al.
Oncotarget, Impact Journals, Llc vol. 8 (31), 50972-50986.

DOI 10.18632/oncotarget.16438

QMRO

22-03-2017

COMPARISON OF IN VIVO OPTICAL COHERENCE TOMOGRAPHY DERIVED PLAQUE PHENOTYPE AND BURDEN WITH HISTOLOGY IN A PORCINE MODEL OF ADVANCED CORONARY ATHEROSCLEROSIS
Poulsen CB, Pedrigi R, Holm N, Pareek N, Kilic I, Post AL, Mario CD, Bentzon J et al.

DOI 10.1016/s0735-1097(17)34461-3

01-03-2017

Zebrafish Model for Functional Screening of Flow-Responsive Genes
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 37 (1), 130-143.

DOI 10.1161/atvbaha.116.308502

QMRO

01-01-2017

2016

Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB
Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Baeriswyl DC, Drakakis EM et al.
Annals of Biomedical Engineering, Springer Science and Business Media Llc vol. 45 (4), 898-909.

DOI 10.1007/s10439-016-1750-z

QMRO

27-10-2016

Influence of shear stress magnitude and direction on atherosclerotic plaque composition
Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L et al.
Royal Society Open Science, The Royal Society vol. 3 (10), 160588-160588.

DOI 10.1098/rsos.160588

QMRO

01-10-2016

Development of a synthetic gene network to modulate gene expression by mechanical forces
Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L et al.
Scientific Reports, Springer Science and Business Media Llc vol. 6 (1)

DOI 10.1038/srep29643

QMRO

12-07-2016

Quantification of plaque stiffness by Brillouin microscopy\n(Conference Presentation)
Antonacci G, Pedrigi R, Krams R, Török P
Optical Elastography and Tissue Biomechanics III 13 Feb 2016 - 18 Feb 2016.

DOI 10.1117/12.2228312

27-04-2016

0109 : Connexin40 controls endothelial activation by dampening NF B activation
Denis J-F, Scheckenbach L, Pfenniger A, Meens M, Krams R, Miquerol L, Taffet S, Chanson M et al.
Archives of Cardiovascular Diseases Supplements, Elsevier Bv vol. 8 (3), 203-203.

DOI 10.1016/s1878-6480(16)30366-4

01-04-2016

Comparison between direct and reverse electroporation of cells in situ: a simulation study
Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW et al.
Physiological Reports, Wiley vol. 4 (6), e12673-e12673.

DOI 10.14814/phy2.12673

QMRO

01-03-2016

Corrigendum to “Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques” [J Mol Cell Cardiol] 89B (2015) 168–172
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R et al.
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 91, 10-10.

DOI 10.1016/j.yjmcc.2015.12.029

01-02-2016

Integration of flow studies for robust selection of mechanoresponsive genes
Maimari N, Pedrigi RM, Russo A, Broda K, Krams R
Thrombosis and Haemostasis, Georg Thieme Verlag Kg vol. 115 (03), 474-483.

DOI 10.1160/th15-09-0704

01-01-2016

A novel assay for regulating transcription factors by flow
Krams RM, Pedrigi RM, Kis Z

01-01-2016

2015

Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R et al.
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 89, 168-172.

DOI 10.1016/j.yjmcc.2015.10.034

01-12-2015

Shear stress-induced atherosclerotic plaque composition in ApoE −/− mice is modulated by connexin37
Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV et al.
Atherosclerosis, Elsevier Bv vol. 243 (1), 1-10.

DOI 10.1016/j.atherosclerosis.2015.08.029

01-11-2015

Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma
Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, de Silva R, Paterson C, Krams R, Török P
Journal of The Royal Society Interface, The Royal Society vol. 12 (112), 20150843-20150843.

DOI 10.1098/rsif.2015.0843

01-11-2015

Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in\n D374Y\n -PCSK9 Hypercholesterolemic Minipigs
Pedrigi RM, Poulsen CB, Mehta VV, Ramsing Holm N, Pareek N, Post AL, Kilic ID, Banya WAS et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 132 (11), 1003-1012.

DOI 10.1161/circulationaha.115.016270

15-09-2015

Enhancement of Non-Invasive Trans-Membrane Drug Delivery Using Ultrasound and Microbubbles During Physiologically Relevant Flow
Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R, Choi JJ
Ultrasound in Medicine &Amp; Biology, Elsevier Bv vol. 41 (9), 2435-2448.

DOI 10.1016/j.ultrasmedbio.2015.05.003

01-09-2015

182 Flow Characteristics Enhanced by the Compliant Arteries and their effects in Vulnerable Plaque Formation
Pereira GDC, Krams R

DOI 10.1136/heartjnl-2015-308066.182

01-06-2015

Mammalian synthetic biology: emerging medical applications
Kis Z, Pereira HS, Homma T, Pedrigi RM, Krams R
Journal of The Royal Society Interface, The Royal Society vol. 12 (106), 20141000-20141000.

DOI 10.1098/rsif.2014.1000

01-05-2015

INDUCTION OF PERTURBED SHEAR STRESS LEADS TO FOCAL ADVANCED ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC MINIPIGS WITH HYPERCHOLESTEROLEMIA
Poulsen CB, Pedrigi RM, Mehta VV, Post A, Pareek N, Holm NR, Kilic D, El-Bahnasawi M et al.

DOI 10.1016/s0735-1097(15)61927-1

01-03-2015

Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors
Dent MR, López-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA et al.
Physical Chemistry Chemical Physics, Royal Society of Chemistry (Rsc) vol. 17 (28), 18393-18402.

DOI 10.1039/c5cp01937k

01-01-2015

Bifurcation and stability analysis of nonlinear dynamic systems using complete search
Villanueva ME, Pereira HSA, Rajyaguru J, Krams R, Chachuat B

01-01-2015

2014

Elevated Uptake of Plasma Macromolecules by Regions of Arterial Wall Predisposed to Plaque Instability in a Mouse Model
Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ, Weinberg PD
Plos One, Public Library of Science (Plos) vol. 9 (12), e115728-e115728.

DOI 10.1371/journal.pone.0115728

QMRO

22-12-2014

Transcriptome analysis of local shear dependent gene expression in endothelial cells during thin-cap fibroatheroma(TCFA) development
Homma T, Caurette P, Silva HJ, Yamada I, Makrydaki E, Bovens S, Pedrigi R, Petretto EG et al.

DOI 10.1016/j.atherosclerosis.2014.10.057

01-12-2014

A novel high-throughput platform for siRNA transfection of primary mammalian cells
Towhidi L, Maimari N, Kis Z, Khodadadi D, Krams R
Atherosclerosis, Elsevier Bv vol. 237 (2), e14-e14.

DOI 10.1016/j.atherosclerosis.2014.10.075

01-12-2014

Forecasting vulnerable plaque response to aemorheological flow
Pereira G, Krams R
Atherosclerosis, Elsevier Bv vol. 237 (2), e12-e12.

DOI 10.1016/j.atherosclerosis.2014.10.068

01-12-2014

Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis
Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W, Krams R
Atherosclerosis, Elsevier Bv vol. 237 (2), e11-e11.

DOI 10.1016/j.atherosclerosis.2014.10.066

01-12-2014

A novel integrated platform for gene network inference and validation: beyond the dream consortium
Maimari N, Towhidi L, Oh D, Broda K, Russo A, Krams R
Atherosclerosis, Elsevier Bv vol. 237 (2), e11-e11.

DOI 10.1016/j.atherosclerosis.2014.10.065

01-12-2014

Symbolic representation and inference of regulatory networks: uncovering mechanosensitive gene networks
Maimari N, Broda K, Kakas A, Russo A, Krams R
Atherosclerosis, Elsevier Bv vol. 237 (2), e11-e11.

DOI 10.1016/j.atherosclerosis.2014.10.064

01-12-2014

Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress
Pedrigi RM, de Silva R, Bovens SM, Mehta VV, Petretto E, Krams R
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 34 (10), 2224-2231.

DOI 10.1161/atvbaha.114.303426

01-10-2014

Biomechanical factors in atherosclerosis: mechanisms and clinical implications
Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P et al.
European Heart Journal, Oxford University Press (Oup) vol. 35 (43), 3013-3020.

DOI 10.1093/eurheartj/ehu353

17-09-2014

In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer ¹⁸F-FEDAA1106
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al.
Molecular Imaging, Sage Publications vol. 13 (6)

DOI 10.2310/7290.2014.00014

01-08-2014

In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106.
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ et al.
Molecular Imaging vol. 13 (6)

DOI 10.2310/7290.2014.00014

01-08-2014

Symbolic Representation and Inference of Regulatory Network Structures
Maimari N, Broda K, Kakas A, Krams R, Russo A
1-48.

DOI 10.1002/9781119005223.ch1

10-07-2014

Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow
Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P et al.
Journal of The Royal Society Interface, The Royal Society vol. 11 (92), 20131156-20131156.

DOI 10.1098/rsif.2013.1156

06-03-2014

Elevated arterial wall permeability may cause vulnerable plaque formation in mice
Mohri Z, Rowland E, Clarke LA, De Luca A, Krams R, Weinberg PD

DOI 10.1016/j.atherosclerosis.2013.11.015

01-02-2014

Modelling the Mechanics of the Circulation: Blood Rheology and Atherosclerosis
Pereira G, Krams R, van Wachem B

DOI 10.1016/j.bpj.2013.11.2127

01-01-2014

An In situ electroporation and flow device for mechanotransduction studies
Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A, Krams R
In Microarrays Principles Applications and Technologies 49-67.
01-01-2014

2013

Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow\n ^†
Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Coppola G et al.
Journal of The Royal Society Interface, The Royal Society vol. 10 (89), 20130578-20130578.

DOI 10.1098/rsif.2013.0578

06-12-2013

Stabilization of atherosclerotic plaques: an update
Yla-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S et al.
European Heart Journal, Oxford University Press (Oup) vol. 34 (42), 3251-3258.

DOI 10.1093/eurheartj/eht301

21-08-2013

M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R, Monaco C
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl 1), P2398-P2398.

DOI 10.1093/eurheartj/eht308.p2398

02-08-2013

Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells
Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al.
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl 1), P582-P582.

DOI 10.1093/eurheartj/eht307.p582

02-08-2013

Method for Percutaneously Introducing, and Removing, Anatomical Stenosis of Predetermined Severity In Vivo: The “Stenotic Stent”
Foin N, Sen S, Petraco R, Nijjer S, Torii R, Kousera C, Broyd C, Mehta V et al.
Journal of Cardiovascular Translational Research, Springer Science and Business Media Llc vol. 6 (4), 640-648.

DOI 10.1007/s12265-013-9476-x

04-06-2013

Systems biology of the functional and dysfunctional endothelium
Frueh J, Maimari N, Homma T, Bovens SM, Pedrigi RM, Towhidi L, Krams R
Cardiovascular Research, Oxford University Press (Oup) vol. 99 (2), 334-341.

DOI 10.1093/cvr/cvt108

06-05-2013

181 M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE
Seneviratne A, Cole J, Goddard M, Udalova I, Krams R, Monaco C

DOI 10.1136/heartjnl-2013-304019.181

01-05-2013

Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE−/− mice
Olivon VC, Fraga-Silva RA, Segers D, Demougeot C, de Oliveira AM, Savergnini SS, Berthelot A, de Crom R et al.
Atherosclerosis, Elsevier Bv vol. 227 (2), 236-243.

DOI 10.1016/j.atherosclerosis.2012.12.014

01-04-2013

The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment
Harrison M, Smith E, Ross E, Krams R, Segers D, Buckley CD, Nash GB, Rainger GE
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 33 (4), 694-701.

DOI 10.1161/atvbaha.112.300379

01-04-2013

Fibromodulin Deficiency Reduces Low-Density Lipoprotein Accumulation in Atherosclerotic Plaques in Apolipoprotein E–Null Mice
Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 33 (2), 354-361.

DOI 10.1161/atvbaha.112.300723

01-02-2013

Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells
Bovens SM, Foin N, O'Clery N, Van der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC et al.

01-01-2013

ARNI: Abductive Inference of Complex Regulatory Network Structures
Maimari N, Turliuc C-R, Broda K, Kakas A, Krams R, Russo A

01-01-2013

M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R, Monaco C

01-01-2013

2012

Macrophage activation during chronic inflammation in atherosclerosis
Falck-Hansen MA, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R, Monaco C

DOI 10.1016/j.atherosclerosis.2012.10.010

01-12-2012

Macrophage polarisation in shear stress modulated atherosclerotic plaque vulnerability
Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Krams R, Monaco C

DOI 10.1016/j.atherosclerosis.2012.10.005

01-12-2012

TCT-231 Investigation of Fractional Flow Reserve Correlation with Direct Anatomical Parameters Using a Percutaneous Model of Coronary Artery Stenosis
Foin N, Sen S, Petraco R, Torii R, Nijjer S, Xu YX, Mehta V, Mayet J et al.

DOI 10.1016/j.jacc.2012.08.254

01-10-2012

Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC et al.
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 53 (2), 299-309.

DOI 10.1016/j.yjmcc.2012.05.011

01-08-2012

Systems and synthetic biology of the vessel wall
Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E et al.
Febs Letters, Wiley vol. 586 (15), 2164-2170.

DOI 10.1016/j.febslet.2012.04.031

03-05-2012

Molecular MR Imaging of Collagen in Mouse Atherosclerosis by Using Paramagnetic CNA35 Micelles
van Bochove GS, Sanders HMHF, de Smet M, Keizer HM, Mulder WJM, Krams R, Strijkers GJ, Nicolay K
European Journal of Inorganic Chemistry, Wiley vol. 2012 (12), 2115-2125.

DOI 10.1002/ejic.201200010

28-03-2012

Poster session 1
Schlueter J, Brand T, Henderson DJ, Boczonadi V, Humbert P, Chaudhry B, Sedmera D, Svatunkova J et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 93 (suppl 1), S9-S45.

DOI 10.1093/cvr/cvr332

15-03-2012

Poster session 3
Nanka O, Krejci E, Pesevski Z, Sedmera D, Smart N, Rossdeutsch A, Dube KN, Riegler J et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 93 (suppl 1), S92-S127.

DOI 10.1093/cvr/cvr336

15-03-2012

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S et al.
Journal of Visualized Experiments, Myjove Corporation (59)

DOI 10.3791/3308

13-01-2012

Kissing Balloon or Sequential Dilation of the Side Branch and Main Vessel for Provisional Stenting of Bifurcations
Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Chan PH, Davies JE, Xu XY et al.
Jacc: Cardiovascular Interventions, Elsevier Bv vol. 5 (1), 47-56.

DOI 10.1016/j.jcin.2011.08.019

01-01-2012

Macrophage heterogeneity in shear stress modulated atherosclerotic plaque development
Seneviratne AN, Cole JE, Goddard ME, Mohri Z, Cross AJ, Krams R, Monaco C

01-01-2012

Arterial stent-associated intimal hyperplasia and wall hypoxia
Caro CG, Seneviratne A, Monaco C, Hou D, Singh J, Gilson P, Burke MG, Heraty KB et al.

01-01-2012

Expression of the regulatory receptor CD200R on macrophages is regulated by polarization signals in atherosclerosis
Falck-Hansen M, Goddard ME, Cole JE, Astola N, Cross AJ, Krams R, Monaco C

01-01-2012

2011

Multi-scale interaction of particulate flow and the artery wall
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW et al.
Med Eng Phys vol. 33 (7), 840-848.

DOI 10.1016/j.medengphy.2010.09.007

01-09-2011

Final proximal post-dilatation is necessary after kissing balloon in bifurcation stenting
Foin N, Secco G, Ghilencea L, Krams R, Di Mario C
Eurointervention, Europa Digital & Publishing vol. 7 (5), 597-604.

DOI 10.4244/eijv7i5a96

01-09-2011

Jailed side branches
Foin N, Viceconte N, Chan PH, Lindsay AC, Krams R, Di Mario C
Journal of Cardiovascular Medicine, Ovid Technologies (Wolters Kluwer Health) vol. 12 (8), 581-582.

DOI 10.2459/jcm.0b013e32834916e3

01-08-2011

Shear stress is a major determinant for getting a heart attack
De Crom R, Leenen P, Nicolay K, Krams R
Hart Bulletin vol. 42 (3), 67-70.
01-06-2011

Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1
Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 108 (8), 950-959.

DOI 10.1161/circresaha.110.233841

15-04-2011

FINAL PROXIMAL POST-DILATATION IS NECESSARY AFTER KISSING BALLOON IN BIFURCATIONS STENTING
Foin N, Secco G, Ghilencea L, Krams R, Mario CD

DOI 10.1016/s0735-1097(11)61721-x

01-04-2011

Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 123 (5), 524-532.

DOI 10.1161/circulationaha.110.979542

08-02-2011

¹⁸FEDAA is a more specific probe than ¹⁸FDG for imaging vascular inflammation
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H et al.
European Journal of Nuclear Medicine and Molecular Imaging vol. 38, S210-S210.
01-01-2011

Endothelial Cx37 expression is regulated by the shear stress responsive transcription factor KLF2
Pfenniger A, Sutter E, Cuhlmann S, Evans PC, Krams R, Kwak BR

01-01-2011

Stabilisation of atherosclerotic plaques
Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R et al.
Thrombosis and Haemostasis, Georg Thieme Verlag Kg vol. 106 (07), 1-19.

DOI 10.1160/th10-12-0784

01-01-2011

Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans
Segers D, Lipton JA, Leenen PJM, Cheng C, Tempel D, Pasterkamp G, Moll FL, de Crom R et al.
International Journal of Inflammation, Hindawi Limited vol. 2011, 1-9.

DOI 10.4061/2011/936109

QMRO

01-01-2011

Bench Micro-CT study and OCT Experience of a Final Proximal Post-dilatation to Optimize Results in Bifurcation Stenting
Foin N, Secco G, Sen S, Davies JE, Krams R, Di Mario C

01-01-2011

Sequential Side Branch and Main Vessel Dilatation instead of Kissing Balloon after Provisional Bifurcation Stenting: Lessons from Micro-CT and Computational Simulations
Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Davies JE, Xu XY, Krams R et al.

01-01-2011

Effects of arginase inhibition on shear stress-induced plaque size and composition
Olivon VC, Segers D, de Oliveira AM, Demougeot C, Bertholet A, de Crom R, Krams R, Stergiopulos N et al.

01-01-2011

2010

Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque
van Bochove GS, Paulis LEM, Segers D, Mulder WJM, Krams R, Nicolay K, Strijkers GJ
Contrast Media &Amp; Molecular Imaging, Wiley vol. 6 (1), 35-45.

DOI 10.1002/cmmi.402

29-09-2010

Microcalcifications in atherosclerotic lesion of apolipoprotein E‐deficient mouse
Debernardi N, Roijers RB, Krams R, De Crom R, Mutsaers PHA, Van Der Vusse GJ
International Journal of Experimental Pathology, Wiley vol. 91 (6), 485-494.

DOI 10.1111/j.1365-2613.2010.00729.x

27-08-2010

YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF- B transcription factors
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason J, Haskard DO, Carlsen H et al.
Heart, Bmj vol. 96 (17), e10-e10.

DOI 10.1136/hrt.2010.205781.4

26-08-2010

Predicting Patient-Specific Expansion of Abdominal Aortic Aneurysms
Helderman F, Manoch IJ, Breeuwer M, Kose U, Boersma H, van Sambeek MRHM, Pattynama PMT, Schouten O et al.
European Journal of Vascular and Endovascular Surgery, Elsevier Bv vol. 40 (1), 47-53.

DOI 10.1016/j.ejvs.2010.02.017

01-07-2010

Endothelial Nitric Oxide Production and Transport in Flow Chambers: The Importance of Convection
Plata AM, Sherwin SJ, Krams R
Annals of Biomedical Engineering, Springer Science and Business Media Llc vol. 38 (9), 2805-2816.

DOI 10.1007/s10439-010-0039-x

14-04-2010

MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque
van Bochove GS, Straathof R, Krams R, Nicolay K, Strijkers GJ
Magnetic Resonance Materials in Physics, Biology and Medicine, Springer Science and Business Media Llc vol. 23 (2), 77-84.

DOI 10.1007/s10334-010-0200-4

13-03-2010

Flow interactions with cells and tissues: Cardiovascular flows and fluid-structure interactions: Sixth international bio-fluid mechanics symposium and workshop, March 28-30, 2008, Pasadena, California
Friedman MH, Krams R, Chandran KB
Annals of Biomedical Engineering vol. 38 (3), 1178-1187.

DOI 10.1007/s10439-010-9900-1

01-03-2010

c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis
Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A et al.
Arterioscl Throm Vas vol. 30 (3), 546-U393.

DOI 10.1161/ATVBAHA.109.201368

01-03-2010

Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid–Structure Interactions
Friedman MH, Krams R, Chandran KB

DOI 10.1007/s10439-010-9900-1

14-01-2010

Shear Stress Modulates the Expression of the Vasoprotective Protein Cx37 in Endothelial Cells
Pfenniger A, Galan K, Wong C, Cuhlmann S, Evans PC, Krams R, Kwak BR

01-01-2010

Dexamethasone arterializes venous endothelial cells by inducing MAP Kinase phosphatase-1 (MKP-1). A novel anti-inflammatory treatment for vein grafts.
Zakkar M, Punjabi P, Anderson J, Smith P, Krams R, Haskard D, Evans P

01-01-2010

Shear stress, inflammation and Atherosclerosis
Krams R, Cuhlmann S, Foin N, Evans P
Artery Research, Springer Science and Business Media Llc vol. 4 (2), 41-41.

DOI 10.1016/j.artres.2010.03.002

01-01-2010

Ex Vivo and In Vivo Regulation of Arginase in Response to Wall Shear Stress
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R, Stergiopuloss N

DOI 10.1007/978-3-642-13039-7_190

01-01-2010

2009

3D Flow reconstruction using ultrasound PIV
Poelma C, Mari JM, Foin N, Tang M-X, Krams R, Caro CG, Weinberg PD, Westerweel J

DOI 10.1007/s00348-009-0781-8

10-11-2009

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 29 (11), 1851-1857.

DOI 10.1161/atvbaha.109.193375

01-11-2009

Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype
Cheng C, Tempel D, van Haperen R, van Damme L, Algür M, Krams R, de Crom R
Atherosclerosis, Elsevier Bv vol. 204 (1), 26-33.

DOI 10.1016/j.atherosclerosis.2009.01.025

01-05-2009

Large variations in absolute wall shear stress levels within one species and between species
de Crom R, Cheng C, Helderman F, Krams R
Atherosclerosis, Elsevier Bv vol. 204 (1), 16-17.

DOI 10.1016/j.atherosclerosis.2008.08.010

01-05-2009

Donor pre-treatment with tacrolimus reduces transplant vasculopathy
Susa D, van de Engel S, van Damme LCA, Roest HP, Krams R, IJzermans JNM, de Bruin RWF
Pharmacological Research, Elsevier Bv vol. 59 (4), 273-278.

DOI 10.1016/j.phrs.2008.12.006

01-04-2009

HIGH SHEAR STRESS SUPPRESSES THE EXPRESSION AND ACTIVITY OF NF-KAPPAB TRANSCRIPTION FACTORS IN ARTERIAL ENDOTHELIUM
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason JM, Haskard DO, Krams R et al.

DOI 10.1136/hrt.2009.178137h

01-01-2009

ENDOTHELIAL CELLS AT ATHEROSUSCEPTIBLE SITES EXPRESS ACTIVATED C-JUN N-TERMINAL KINASE WHICH INDUCES PRO-APOPTOTIC MOLECULES
Chaudhury HA, Zakkar M, Boyle J, Dennis J, van der Heiden K, Luong L, Cuhlmann S, Mason JM et al.

DOI 10.1136/hrt.2009.178137f

01-01-2009

SHEAR STRESS AND NITRIC OXIDE TRANSPORT AFFECT NF-KB DYNAMICS IN ENDOTHELIAL CELLS
Foin N, Plata-Garcia A, Cuhlmann S, Evans PC, Caro CG, Krams R

DOI 10.1136/hrt.2009.178137m

01-01-2009

ACTIVATION OF NF-E2 RELATED FACTOR-2 (NRF2) PROTECTS ARTERIES FROM EXHIBITING A PRO-INFLAMMATORY STATE
Zakkar M, van der Heiden K, Chaudhury H, Krams R, Haskard DO, Mason JC, Evans PC

DOI 10.1136/hrt.2009.181669m

01-01-2009

Shear Stress and Nitric Oxide Transport Affect NF-κB Dynamics In Endothelial Cells
Foin N, Plata-Garcia A, Qin Q, Cuhlmann S, Evans PC, Caro CG, Krams R

01-01-2009

SHEAR STRESS AND MASS TRANSPORT AFFECTS NF kappa B DYNAMICS IN ENDOTHELIAL CELLS
Foin N, Plata-Garcia A, Cuhlmann S, Evans P, Caro C, Krams R
J Physiol Sci vol. 59, 324-324.
01-01-2009

2008

Atherosclerosis: cell biology and lipoproteins - shear stress and inflammation in plaque formation: new evidence
Segers D, Weinberg P, Krams R
Current Opinion in Lipidology, Ovid Technologies (Wolters Kluwer Health) vol. 19 (6), 627-628.

DOI 10.1097/mol.0b013e328318db32

01-12-2008

Monocyte Adhesion in Atherosclerosis: A Biomechanical Approach
Segers D, Cheng C, Crom RD, Kirschbaum SWM, Oostlander AE, Helderman F, Wamel AV, Slager CJ et al.
Vascular Disease Prevention, Bentham Science Publishers Ltd. vol. 2 (1), 227-235.

DOI 10.2174/1567270000502010027

01-12-2008

Personalised imaging and biomechanical modelling of large vessels
Krams R, Breeuwer M, van de Vosse F
Medical &Amp; Biological Engineering &Amp; Computing, Springer Science and Business Media Llc vol. 46 (11), 1057-1058.

DOI 10.1007/s11517-008-0417-9

01-11-2008

A primer on the immune system in the pathogenesis and treatment of atherosclerosis
Segers D, Garcia-Garcia H, Cheng C, de Crom R, Krams R, Wentzel J, van der Steen A, Serruys P et al.
Eurointervention, Europa Digital & Publishing vol. 4 (3), 378-390.

DOI 10.4244/eijv4i3a67

01-11-2008

Pulmonary artery size and function after Fontan operation at a young age
Robbers‐Visser D, Helderman F, Strengers JL, van Osch‐Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R et al.
Journal of Magnetic Resonance Imaging, Wiley vol. 28 (5), 1101-1107.

DOI 10.1002/jmri.21544

28-10-2008

Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update
Ridger V, Krams R, Carpi A, Evans PC
Biomedicine &Amp; Pharmacotherapy, Elsevier Bv vol. 62 (8), 536-540.

DOI 10.1016/j.biopha.2008.07.053

01-10-2008

1057 Pulmonary artery size and function after Fontan operation at young age: assessment with phase contrast magnetic resonance imaging
Robbers-Visser D, Helderman F, Strengers JL, van Osch-Gevers L, Kapusta L, Pattynama PMT, Bogers AJJC, Krams R et al.
Journal of Cardiovascular Magnetic Resonance, Elsevier Bv vol. 10, A182-A182.

DOI 10.1186/1532-429x-10-s1-a182

01-10-2008

Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 103 (7), 726-732.

DOI 10.1161/circresaha.108.183913

26-09-2008

Towards patient-specific risk assessment of abdominal aortic aneurysm
Breeuwer M, de Putter S, Kose U, Speelman L, Visser K, Gerritsen F, Hoogeveen R, Krams R et al.
Medical &Amp; Biological Engineering &Amp; Computing, Springer Science and Business Media Llc vol. 46 (11), 1085-1095.

DOI 10.1007/s11517-008-0393-0

23-09-2008

MAP KINASE PHOSPHATASE-1 SUPPRESSES ENDOTHELIAL ACTIVATION IN REGIONS OF THE ARTERIAL TREE THAT ARE RESISTANT TO ATHEROSCLEROSIS
Zakkar M, Chaudhury H, Krams R, Mason JC, Clark AR, Haskard DO, Evans PC

DOI 10.1016/j.atherosclerosis.2008.05.006

01-08-2008

DONOR PRE-TREATMENT WITH TACROLIMUS EDUCES TRANSPLANT VASCULOPATHY
de Bruin RWF, Susa D, van den Engel S, van Damme LA, Roest HP, Krams R, Jzermans JNMI
Transplantation, Ovid Technologies (Wolters Kluwer Health) vol. 86 (2S), 633-633.

DOI 10.1097/01.tp.0000330936.86118.f6

27-07-2008

REGULATION OF ARGINASE IN RESPONSE SHEAR STRESS: NEW POTENTIAL THERAPEUTIC TARGET ATHEROSCLEROSIS?
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R, Stergiopulos N
Journal of Biomechanics, Elsevier Bv vol. 41, S184-S184.

DOI 10.1016/s0021-9290(08)70184-2

01-07-2008

A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness
Helderman F, Manoch IJ, Breeuwer M, Kose U, Schouten O, van Sambeek MRM, Poldermans D, Pattynama PTM et al.
Medical &Amp; Biological Engineering &Amp; Computing, Springer Science and Business Media Llc vol. 46 (11), 1121-1127.

DOI 10.1007/s11517-008-0358-3

03-06-2008

Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis
Van der Heiden K, Hierck BP, Krams R, de Crom R, Cheng C, Baiker M, Pourquie MJBM, Alkemade FE et al.
Atherosclerosis, Elsevier Bv vol. 196 (2), 542-550.

DOI 10.1016/j.atherosclerosis.2007.05.030

01-02-2008

Atherosclerosis: cell biology and lipoproteins - new developments in imaging of inflammation of the vulnerable plaque
Foin N, Evans P, Krams R
Curr Opin Lipidol vol. 19 (1), 98-100.

DOI 10.1097/MOL.0b013e3282f41b60

01-02-2008

Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis?
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R, Stergiopulos N

01-01-2008

P1.57 MODULATION OF ARGINASE IN RESPONSE TO WALL SHEAR STRESS
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R, Stergiopulos N
Artery Research, Springer Science and Business Media Llc vol. 2 (3), 105-105.

DOI 10.1016/j.artres.2008.08.364

01-01-2008

2007

Rapamycin modulates the eNOS vs. shear stress relationship
Cheng C, Tempel D, Oostlander A, Helderman F, Gijsen F, Wentzel J, van Haperen R, Haitsma DB et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 78 (1), 123-129.

DOI 10.1093/cvr/cvm103

13-12-2007

Subharmonic Contrast Intravascular Ultrasound for Vasa Vasorum Imaging
Goertz DE, Frijlink ME, Tempel D, Bhagwandas V, Gisolf A, Krams R, de Jong N, van der Steen AFW
Ultrasound in Medicine &Amp; Biology, Elsevier Bv vol. 33 (12), 1859-1872.

DOI 10.1016/j.ultrasmedbio.2007.05.023

01-12-2007

Large variations in absolute wall shear stress levels within one species and between species
Cheng C, Helderman F, Tempel D, Segers D, Hierck B, Poelmann R, van Tol A, Duncker DJ et al.
Atherosclerosis, Elsevier Bv vol. 195 (2), 225-235.

DOI 10.1016/j.atherosclerosis.2006.11.019

01-12-2007

Abstract 879: The Chemokine CXCL10 Is Involved In The Development Of Atherosclerotic Plaque Vulnerability
Segers D, de Crom R, Leenen P, Pasterkamp G, Krams R
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 116 (suppl_16)

DOI 10.1161/circ.116.suppl_16.ii_172

16-10-2007

Effect of shear stress on vascular inflammation and plaque development
Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC, Krams R
Current Opinion in Lipidology, Ovid Technologies (Wolters Kluwer Health) vol. 18 (5), 527-533.

DOI 10.1097/mol.0b013e3282ef7716

01-10-2007

12A-2 Subharmonic Contrast Intravascular Ultrasound
Goertz DE, Frijlink ME, Tempel D, Krams R, de Jong N, van der Steen AF
2007 IEEE Ultrasonics Symposium 28 Oct 2007 - 31 Oct 2007.

DOI 10.1109/ultsym.2007.269

01-10-2007

Shear stress and the vulnerable plaque
Wentzel J, Gijsen F, Krams R, de Crom R, Cheng C, Groen H, van der Giessen A, van der Steen A
In The Vulnerable Plaque, Second Edition, Crc Press 233-244.

DOI 10.3109/9781439804537-23

13-06-2007

Coronary flow reserve in hypertrophic cardiomyopathy: relation with microvascular dysfunction and pathophysiological characteristics
Kofflard MJ, Michels M, Krams R, Kliffen M, Geleijnse ML, Cate FJT, Serruys PW
Netherlands Heart Journal, Springer Science and Business Media Llc vol. 15 (6), 209-215.

DOI 10.1007/bf03085982

01-06-2007

Assessment of Unstable Atherosclerosis in Mice
Jackson CL, Bennett MR, Biessen EAL, Johnson JL, Krams R
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 27 (4), 714-720.

DOI 10.1161/01.atv.0000261873.86623.e1

01-04-2007

Shear stress–induced changes in atherosclerotic plaque composition are modulated by chemokines
Cheng C, Tempel D, van Haperen R, de Boer HC, Segers D, Huisman M, van Zonneveld AJ, Leenen PJM et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 117 (3), 616-626.

DOI 10.1172/jci28180

01-03-2007

Gelatinolytic Activity in Atherosclerotic Plaques Is Highly Localized and Is Associated With Both Macrophages and Smooth Muscle Cells In Vivo
Segers D, Helderman F, Cheng C, van Damme LCA, Tempel D, Boersma E, Serruys PW, de Crom R et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 115 (5), 609-616.

DOI 10.1161/circulationaha.106.636415

06-02-2007

Vasa vasorum and molecular imaging of atherosclerotic plaques using nonlinear contrast intravascular ultrasound
Goertz DE, Frijlink ME, Krams R, de Jong N, van der Steen AFW
Netherlands Heart Journal, Springer Science and Business Media Llc vol. 15 (2), 77-80.

DOI 10.1007/bf03085959

01-02-2007

Donor pre-treatment with tacrolimus reduces transplant vasculopathy
Susa D, van den Engel S, van Damme LA, Roest HP, Krams R, IJiermans JNM, De Bruin RWF

01-01-2007

The chemokine CXCL10 is involved in the development of atherosclerotic plaque vulnerability
Segers D, de Crom R, Leenen P, Pasterkamp G, Krams R

01-01-2007

Modulation of arginases by different patterns of shear stress: new signaling pathway in atherogenesis?
Da Silva RF, Gambillara V, Krams R, Stergiopulos N
Computer Methods in Biomechanics and Biomedical Engineering, Informa Uk Limited vol. 10 (sup1), 77-78.

DOI 10.1080/10255840701478497

01-01-2007

P.096 ROLE OF ARGINASE PATHWAY IN RESPONSE TO SHEAR STRESS: NEW POTENTIAL THERAPEUTIC TARGETS FOR ATHEROSCLEROSIS?
da Silva RF, Gambillara V, Cheng C, Segers D, de Crom R, Krams R, Stergiopulos N
Artery Research, Springer Science and Business Media Llc vol. 1 (2), 74-74.

DOI 10.1016/j.artres.2007.07.030

01-01-2007

The Influence of Shear Stress on Restenosis
Thury A, Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW, Slager CJ
In Essentials of Restenosis, Humana Press 59-83.

DOI 10.1007/978-1-59745-001-0_5

01-01-2007

2006

Response to Letter Regarding Article, “Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress”
Cheng C, Tempel D, van der Baan A, Krams R, Daemen MJAP, van Haperen R, Grosveld F, de Crom R
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 114 (22)

DOI 10.1161/circulationaha.106.658302

28-11-2006

Harmonic intravascular ultrasound imaging with a dual-frequency catheter
Frijlink ME, Goertz DE, Vos HJ, Tesselaar E, Blacquière G, Gisolf A, Krams R, van der Steen AFW
Ultrasound in Medicine &Amp; Biology, Elsevier Bv vol. 32 (11), 1649-1654.

DOI 10.1016/j.ultrasmedbio.2006.05.024

01-11-2006

Intravascular ultrasound tissue harmonic imaging in vivo
Frijlink M, Goertz D, Van Damme L, Krams R, W. Van Der Steen A
Ieee Transactions On Ultrasonics, Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers (Ieee) vol. 53 (10), 1844-1852.

DOI 10.1109/tuffc.2006.116

01-10-2006

Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R, de Crom R
Vascular Pharmacology, Elsevier Bv vol. 45 (3), e91-e92.

DOI 10.1016/j.vph.2006.08.258

01-09-2006

Patterns of fluid shear stress determine atherosclerotic lesion size and vulnerability
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R, de Crom R
Vascular Pharmacology, Elsevier Bv vol. 45 (3), e51-e51.

DOI 10.1016/j.vph.2006.08.136

01-09-2006

Contrast Harmonic Intravascular Ultrasound
Goertz DE, Frijlink ME, Tempel D, van Damme LCA, Krams R, Schaar JA, ten Cate FJ, Serruys PW et al.
Investigative Radiology, Ovid Technologies (Wolters Kluwer Health) vol. 41 (8), 631-638.

DOI 10.1097/01.rli.0000229773.11715.da

01-08-2006

Shear stress is associated with markers of plaque vulnerability and MMP-9 activity.
Krams R, Cheng C, Helderman F, Verheye S, van Damme LCA, Mousavi Gourabi B, Tempel D, Segers D et al.
Eurointervention : Journal of Europcr in Collaboration With The Working Group On Interventional Cardiology of The European Socie vol. 2 (2), 250-256.
01-08-2006

Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R, de Crom R
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 113 (23), 2744-2753.

DOI 10.1161/circulationaha.105.590018

13-06-2006

Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress
Cheng C, Tempel D, Van Haperen R, Van Der Baan A, Grosveld F, Daemen MJAP, Krams R, De Crom R
Circulation vol. 113 (23), 2744-2753.

DOI 10.1161/CIRCULATIONAHA.105.590018

01-06-2006

Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients
Nette RW, Ie EHY, Vletter WB, Krams R, Weimar W, Zietse R
Nephrology Dialysis Transplantation, Oxford University Press (Oup) vol. 21 (5), 1305-1311.

DOI 10.1093/ndt/gfk070

31-01-2006

High IP-10 levels identify plaques with a vulnerable phenotype
Lipton J, Segers D, Cheng C, Duckers H, Krams R, Tempel D, Busser E, De Kleijn D et al.

01-01-2006

Visualization of the Vulnerable Plaque
Krams R, Schaar J, Helderman F, Cheng C, Gourabi BM, van Damme LCA, Segers D, Regar E et al.
In Cardiovascular Research, Springer Us 221-234.

DOI 10.1007/0-387-23329-6_12

01-01-2006

Numerical model for predicting dilatation of an Abdominal Aortic Aneurysm (AAA)
Helderman F, Schouten O, Manoch I, Buffart H, van der Steen AFW, Krams R
Journal of Biomechanics, Elsevier Bv vol. 39, S604-S604.

DOI 10.1016/s0021-9290(06)85508-9

01-01-2006

Shear stress and atherosclerosis
Krams R
Journal of Biomechanics, Elsevier Bv vol. 39, S287-S287.

DOI 10.1016/s0021-9290(06)84109-6

01-01-2006

2005

Shear Stress Biology of the Endothelium
Davies PF, Spaan JA, Krams R
Annals of Biomedical Engineering, Springer Science and Business Media Llc vol. 33 (12), 1714-1718.

DOI 10.1007/s10439-005-8774-0

01-12-2005

Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique
Cheng C, van Haperen R, de Waard M, van Damme LCA, Tempel D, Hanemaaijer L, van Cappellen GWA, Bos J et al.
Blood, American Society of Hematology vol. 106 (12), 3691-3698.

DOI 10.1182/blood-2005-06-2326

01-12-2005

In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity
Krams R, Verheye S, van Damme LCA, Tempel D, Gourabi BM, Boersma E, Kockx MM, Knaapen MWM et al.
European Heart Journal, Oxford University Press (Oup) vol. 26 (20), 2200-2205.

DOI 10.1093/eurheartj/ehi461

05-09-2005

Myocardial contractility does not determine the haemodynamic response during dialysis
Ie EHY, Krams R, Vletter WB, Nette RW, Weimar W, Zietse R
Nephrology Dialysis Transplantation, Oxford University Press (Oup) vol. 20 (11), 2465-2471.

DOI 10.1093/ndt/gfi088

23-08-2005

Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries
Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, Serruys PW, De Feyter PJ, Slager CJ
Journal of Biomechanics, Elsevier Bv vol. 38 (7), 1551-1555.

DOI 10.1016/j.jbiomech.2004.06.022

01-07-2005

DOI 10.2174/1567270054368998

01-07-2005

Effect of vessel curvature on Doppler derived velocity profiles and fluid flow
Krams R, Bambi G, Guidi F, Helderman F, van der Steen AFW, Tortoli P
Ultrasound in Medicine &Amp; Biology, Elsevier Bv vol. 31 (5), 663-671.

DOI 10.1016/j.ultrasmedbio.2005.01.011

01-05-2005

Letter Regarding Article by Korshunov and Berk, “Strain-Dependent Vascular Remodeling: The ‘Glagov Phenomenon’ Is Genetically Determined”
Wentzel JJ, Krams R, Slager CJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 111 (9)

DOI 10.1161/01.cir.0000157072.64410.01

08-03-2005

Three-Dimensional Palpography of Human Coronary Arteries
Schaar* JA, Korte* CL, Mastik F, Damme LCA, Krams R, Serruys PW, Steen AFW
Herz Kardiovaskul�Re Erkrankungen, Springer Science and Business Media Llc vol. 30 (2), 125-133.

DOI 10.1007/s00059-005-2642-4

01-02-2005

Vulnerable lesions induced by low shear stress are characterized by expression of specific inflammatory chemokines
Cheng C, Tempel D, van Haperen R, de Crom R, Krams R

01-01-2005

Patterns of fluid shear stress determine Atherosclerotic lesion size and vulnerability
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R, de Crom R

01-01-2005

Donor pre-treatment with tacrolimus reduces matrix metallo proteinase activity and transplant arteriosclerosis.
Susa D, de Engel SV, van Damme LCA, Roest HP, Krams R, Ijzermans JNM, de Bruin RWF

01-01-2005

Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype in apoE KO mice
Cheng C, Tempel D, van Damme L, van Gaalen K, van Haperen R, Krams R, de Crom R

01-01-2005

2004

Diastolic coronary vascular reserve: a new index to detect changes in the coronary microcirculation in hypertrophic cardiomyopathy
Krams R, Ten Cate FJ, Carlier SG, van der Steen AFW, Serruys PW
Journal of The American College of Cardiology, Elsevier Bv vol. 43 (4), 670-677.

DOI 10.1016/j.jacc.2003.09.046

01-02-2004

Intravascular thermography: Immediate functional and morphological vascular findings
Verheye S
European Heart Journal, Oxford University Press (Oup) vol. 25 (2), 158-165.

DOI 10.1016/j.ehj.2003.10.023

01-01-2004

The Role of Shear Stress in Atherosclerosis: Action Through Gene Expression and Inflammation?
Cheng C, de Crom R, van Haperen R, Helderman F, Gourabi BM, van Damme LCA, Kirschbaum SW, Slager CJ et al.
Cell Biochemistry and Biophysics, Springer Science and Business Media Llc vol. 41 (2), 279-294.

DOI 10.1385/cbb:41:2:279

01-01-2004

In vivo induced changes in shear stress patterns affect the expression and the intracellular localization of endothelial nitric oxide synthase
Cheng C, van Haperen R, de Waard M, de Crom R, Krams R

01-01-2004

In vivo induction of low shear stress and oscillatory shear stress causes atherosclerosis
Cheng C, de Waard M, van Haperen R, Tempel D, van der Baan A, Krams R, de Crom R

01-01-2004

Multi-Dimensional Computed Coronary Visualization
van Ooijen PMA, Irwan R, Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R et al.
In Medical Radiology, Springer Berlin Heidelberg 227-282.

DOI 10.1007/978-3-662-06419-1_16

01-01-2004

2003

Functional Expression of Endothelial Nitric Oxide Synthase Fused to Green Fluorescent Protein in Transgenic Mice
van Haperen R, Cheng C, Mees BME, van Deel E, de Waard M, van Damme LCA, van Gent T, van Aken T et al.
The American Journal of Pathology, Elsevier Bv vol. 163 (4), 1677-1686.

DOI 10.1016/s0002-9440(10)63524-9

01-10-2003

The effect of reduced blood-flow on the coronary wall temperature Are significant lesions suitable for intravascular thermography?
Diamantopoulos L
European Heart Journal, Oxford University Press (Oup) vol. 24 (19), 1788-1795.

DOI 10.1016/s0195-668x(03)00440-8

01-10-2003

Imaging of coronary atherosclerosis and identification of the vulnerable plaque.
de Feyter PJ, Serruys PW, Nieman K, Mollet N, Cademartiri F, van Geuns RJ, Slager C, van der Steen AFW et al.
Netherlands Heart Journal : Monthly Journal of The Netherlands Society of Cardiology and The Netherlands Heart Foundation vol. 11 (9), 347-358.
01-09-2003

Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling
Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ, Slager CJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 108 (1), 17-23.

DOI 10.1161/01.cir.0000078637.21322.d3

08-07-2003

Augmentation of Wall Shear Stress Inhibits Neointimal Hyperplasia After Stent Implantation
Carlier SG, van Damme LCA, Blommerde CP, Wentzel JJ, van Langehove G, Verheye S, Kockx MM, Knaapen MWM et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 107 (21), 2741-2746.

DOI 10.1161/01.cir.0000066914.95878.6d

03-06-2003

Shear stress, vascular remodeling and neointimal formation
Wentzel JJ, Gijsen FJH, Stergiopulos N, Serruys PW, Slager CJ, Krams R
Journal of Biomechanics, Elsevier Bv vol. 36 (5), 681-688.

DOI 10.1016/s0021-9290(02)00446-3

01-05-2003

Inflammation and Atherosclerosis:
KRAMS ROB, SEGERS D, GOURABI BM, MAAT W, CHENG C, VAN PELT C, VAN DAMME LCA, DE FEYTER PIM et al.
Journal of Interventional Cardiology, Wiley vol. 16 (2), 107-113.

DOI 10.1046/j.1540-8183.2003.08021.x

01-04-2003

929 Plaque temperature heterogeneity is associated with macrophage accumulation and metalloproteinase activity
KRAMS R

DOI 10.1016/s0195-668x(03)94221-7

01-03-2003

P1760 Local macrophage accumulation in atherosclerotic rabbit aortas as determined by a novel three-dimensional histology technique
GOURABI B

DOI 10.1016/s0195-668x(03)94898-6

01-03-2003

P2242 Augmentation of wall shear stress inhibits neo intimal hyperplasia and inflammation after stent implantation
KRAMS R

DOI 10.1016/s0195-668x(03)95236-5

01-03-2003

P2207 High shear stress is predictive for markers of plaque inflammation
KRAMS R

DOI 10.1016/s0195-668x(03)95201-8

01-03-2003

eNOS expression responds to changes in shear stress: Direct demonstration in a novel in vivo mouse model
Cheng C, van Haperen R, de Waard M, de Crom R, Krams R

01-01-2003

Shear stress is associated with markers of plaque vulnerability
Krams R, van Damme L, Tempel D, Gourabi BM, van der Steen AF

01-01-2003

Diagnosis of vulnerable plaques in the cardiac catheterization laboratory
Schaar JA, van der Steen AFW, Arampatzis CA, Krams R, Slager CJ, ten Have AG, van de Poll SW, Gijsen FJ et al.
In Vascular Ultrasound, Springer Japan 220-234.

DOI 10.1007/978-4-431-67871-7_14

01-01-2003

Shear stress and the IVUS derived vessel wall thickness
Wentzel JJ, Cheng C, de Crom R, Stergiopulos N, Serruys PW, Slager CJ, Krams R
In Vascular Ultrasound, Springer Japan 148-164.

DOI 10.1007/978-4-431-67871-7_10

01-01-2003

Coronary 3-D angiography, 3-D ultrasound and their fusion
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R, van der Giessen WJ, Serruys PW et al.
In Vascular Ultrasound, Springer Japan 121-147.

DOI 10.1007/978-4-431-67871-7_9

01-01-2003

2002

High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization
Thury A, van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Sianos G, Wentzel JJ et al.
American Heart Journal, Elsevier Bv vol. 144 (1), 136-143.

DOI 10.1067/mhj.2002.123110

01-07-2002

Focal In-Stent Restenosis Near Step-Up
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 105 (23)

DOI 10.1161/01.cir.0000018282.32332.13

11-06-2002

Determination of shear stress in patients confirms that lumen preservation in atherosclerosis is associated with shear stress regulation
Wentzel JJ, Janssen EH, Krams R, Schuurbiers JCH, van der Giessen WJ, Serruys PW, de Feyter PJ, Slager CJ

DOI 10.1016/s0735-1097(02)80966-4

01-03-2002

Calcium Sensitizer EMD 57033, But Not the β 1 -Adrenoreceptor Agonist Dobutamine, Increases Mechanical Efficiency in Stunned Myocardium
Trines SAIP, Smits CAG, van der Moer J, Slager CJ, Verdouw PD, Krams R
Journal of Cardiovascular Pharmacology, Ovid Technologies (Wolters Kluwer Health) vol. 39 (1), 61-72.

DOI 10.1097/00005344-200201000-00008

01-01-2002

Images in cardiovascular medicine. Focal in-stent restenosis near step-up: roles of low and oscillating shear stress?
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW et al.
Circulation vol. 105 (23), e185-e187.

DOI 10.1161/01.cir.0000018282.32332.13

01-01-2002

Vulnerable plaque detection with 3-dimensional palpography
de Korte CL, Schaar JA, Mastik F, van Damme LCA, Krams R, Serruys PW, van der Steen AFW

01-01-2002

The relationship between wall thickness and shear stress in coronary arteries of patients
Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ, Slager CJ

01-01-2002

Reduced end-systolic elastance indicating poor left ventricular contractility in hemodialysis patients.
Ie EHY, Krams R, Vletter WB, ten Cate FJ, Nette RW, Weimar W, Zietse R

01-01-2002

2001

Prominent Role of Tensile Stress in Propagation of a Dissection After Coronary Stenting
Thury A, Wentzel JJ, Schuurbiers JCH, Ligthart JMR, Krams R, de Feyter PJ, Serruys PW, Slager CJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 104 (11)

DOI 10.1161/hc3601.095216

11-09-2001

Decrease in coronary vascular volume in systole augments cardiac contraction
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P, Westerhof N
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 281 (2), H731-H737.

DOI 10.1152/ajpheart.2001.281.2.h731

01-08-2001

Shear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty
Wentzel JJ, Kloet J, Andhyiswara I, Oomen JAF, Schuurbiers JCH, de Smet BJGL, Post MJ, de Kleijn D et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 104 (1), 91-96.

DOI 10.1161/01.cir.104.1.91

03-07-2001

Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency
Trines S
Cardiovascular Research, Oxford University Press (Oup) vol. 51 (1), 122-130.

DOI 10.1016/s0008-6363(01)00277-2

01-07-2001

Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries
Wentzel JJ, Krams R, Schuurbiers JCH, Oomen JA, Kloet J, van der Giessen WJ, Serruys PW, Slager CJ
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 103 (13), 1740-1745.

DOI 10.1161/01.cir.103.13.1740

03-04-2001

Functional assessment of eNOS transgenesis in mice aortas
Krams R, van Damme LCA, Wentzel JJ, De Crom R, Haperen R, Van Aken T

01-01-2001

Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency
Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD, Krams R

01-01-2001

An increased wall shear stress inhibits neointimal hyperplasia after stent implantation: preliminary in vivo experience of the ARED flow divider in a rabbit model of restenosis
Carlier SG, van Damme LC, Blommerde CP, Van Langenhove G, Wentzel JJ, van der Giessen WJ, Verdouw PD, Krams R et al.

01-01-2001

Novel method for in vivo calculation of absolute sheer stress at any location of a stented human coronary artery
Thury A, Wentzel JJ, Janssen EH, Krams R, Oomen JA, Schuurbiers JCH, Ligthart JMR, Serruys PW et al.

01-01-2001

Decrease in coronary vascular volume in systole augments cardiac contraction
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P, Westerhof N
American Journal of Physiology Heart and Circulatory Physiology vol. 281 (2 50-2), H731-H737.

DOI 10.1152/ajpheart.2001.281.2.h731

01-01-2001

2000

Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution
Wentzel JJ, M. Whelan D, van der Giessen WJ, van Beusekom HMM, Andhyiswara I, Serruys PW, Slager CJ, Krams R
Journal of Biomechanics, Elsevier Bv vol. 33 (10), 1287-1295.

DOI 10.1016/s0021-9290(00)00066-x

01-10-2000

In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca2+ in stunned myocardium
de Zeeuw S, Trines SAIP, Krams R, Duncker DJ, Verdouw PD
European Journal of Pharmacology, Elsevier Bv vol. 403 (1-2), 99-109.

DOI 10.1016/s0014-2999(00)00513-6

01-09-2000

Efficiency of energy transfer, but not external work, is maximized in stunned myocardium
Trines SAIP, Slager CJ, Van der Moer J, Verdouw PD, Krams R
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 279 (3), H1264-H1273.

DOI 10.1152/ajpheart.2000.279.3.h1264

01-09-2000

True 3-Dimensional Reconstruction of Coronary Arteries in Patients by Fusion of Angiography and IVUS (ANGUS) and Its Quantitative Validation
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Kloet J, Krams R, von Birgelen C, van der Giessen WJ et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 102 (5), 511-516.

DOI 10.1161/01.cir.102.5.511

01-08-2000

Helical Velocity Patterns in a Human Coronary Artery
Van Langenhove G, Wentzel JJ, Krams R, Slager CJ, Hamburger JN, Serruys PW
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 102 (3)

DOI 10.1161/01.cir.102.3.e22

18-07-2000

Cardiovascular profile of the calcium sensitizer EMD 57033 in open‐chest anaesthetized pigs with regionally stunned myocardium
De Zeeuw S, Trines SAIP, Krams R, Verdouw PD, Duncker DJ
British Journal of Pharmacology, Wiley vol. 129 (7), 1413-1422.

DOI 10.1038/sj.bjp.0703231

01-04-2000

Quantification of plaque volume, shear stress on the endothelium, and mechanical properties of the arterial wall with intravascular ultrasound imaging
Bom N, de Korte CL, Wentzel JJ, Krams R, Carlier SG, van der Steen AWF, Slager CJ, Roelandt JRTC
Zeitschrift F�R Kardiologie, Springer Science and Business Media Llc vol. 89 (14), S105-S111.

DOI 10.1007/s003920070108

01-02-2000

Coronary systolic flow impediment is functional in cardiac contraction
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Sipkema P, Westerhof N

01-01-2000

Efficiency of energy transfer, but not external work, is maximized in stunned myocardium
Trines SAIP, Slager CJ, Van Der Moer J, Verdouw PD, Krams R
American Journal of Physiology Heart and Circulatory Physiology vol. 279 (3 48-3), H1264-H1273.

DOI 10.1152/ajpheart.2000.279.3.h1264

01-01-2000

1999

Ca2+ sensitization and diastolic function of normal and stunned porcine myocardium
Soei LK, de Zeeuw S, Krams R, Duncker DJ, Verdouw PD
European Journal of Pharmacology, Elsevier Bv vol. 386 (1), 55-67.

DOI 10.1016/s0014-2999(99)00684-6

01-12-1999

Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system
Krams R, Wentzel JJ, Cespedes I, Vinke R, Carlier S, van der Steen AFW, Lancee CT, Slager CJ
Ultrasound in Medicine &Amp; Biology, Elsevier Bv vol. 25 (5), 803-810.

DOI 10.1016/s0301-5629(99)00018-6

01-06-1999

The relationship between neo intimal thickness and shear stress after wallstent implantation in human coronary arteries at 6 months follow up
Wentzel JJ, Kloet J, Krams R, Serruys PW, Slager CJ

01-01-1999

External work recruitment can be restored in stunned myocardium without increasing oxygen consumption using EMD 57033, a calcium sensitizer
Trines SA, Van der Moer J, Krams R, Slager CJ, Van Meegen JR, Verdouw PD

01-01-1999

1998

AT\n ₁\n Receptor A/C\n ¹¹⁶⁶\n Polymorphism Contributes to Cardiac Hypertrophy in Subjects With Hypertrophic Cardiomyopathy
Osterop APRM, Kofflard MJM, Sandkuijl LA, Cate FJT, Krams R, Schalekamp MADH, Danser AHJ
Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 32 (5), 825-830.

DOI 10.1161/01.hyp.32.5.825

01-11-1998

Cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium
van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Roelandt JRT, Bom N
European Journal of Ultrasound, Elsevier Bv vol. 7, S45-S45.

DOI 10.1016/s0929-8266(97)80279-0

01-02-1998

Decreased Coronary Flow Reserve in Hypertrophic Cardiomyopathy Is Related to Remodeling of the Coronary Microcirculation
Krams R, Kofflard MJM, Duncker DJ, Von Birgelen C, Carlier S, Kliffen M, Cate FJT, Serruys PW
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 97 (3), 230-233.

DOI 10.1161/01.cir.97.3.230

27-01-1998

Shear stress in atherosclerosis, and vascular remodelling.
Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B et al.
Seminars in Interventional Cardiology Siic vol. 3 (1), 39-44.
01-01-1998

AT₁ receptor A/C¹¹⁶⁶ polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy
Osterop APRM, Kofflard MJM, Sandkuijl LA, ten Cate FJ, Krams R, Schalekamp MADH, Danser AHJ
Hypertension vol. 32 (5), 825-830.

DOI 10.1161/01.HYP.32.5.825

01-01-1998

True 3-D reconstruction of coronary arteries in patients shows accurate correspondence between x-ray and IVUS derived dimensions.
Stager CJ, Wentzel JJ, Schuurbiers JC, Oomen JA, Krams R, Achterberg H, Kloet J, deFeyter PJ

01-01-1998

1997

Evidence for a pivotal role of shear stress on the endothelium in human atherosclerosis
Krams R, Wentzel JJ, Oomen J, Schuurbier J, Vinke R, Slager CJ

01-12-1997

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Dongsheng FA, Kie Soei LO, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, Krams ROB
American Journal of Physiology Heart and Circulatory Physiology vol. 42 (5), H2146-H2154.
01-12-1997

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, Krams R
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 273 (5), H2146-H2154.

DOI 10.1152/ajpheart.1997.273.5.h2146

01-11-1997

Evaluation of Endothelial Shear Stress and 3D Geometry as Factors Determining the Development of Atherosclerosis and Remodeling in Human Coronary Arteries in Vivo
Krams R, Wentzel JJ, Oomen JAF, Vinke R, Schuurbiers JCH, de Feyter PJ, Serruys PW, Slager CJ
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 17 (10), 2061-2065.

DOI 10.1161/01.atv.17.10.2061

01-10-1997

Cardiac depression after experimental air embolism in pigs: role of addition of a surface-active agent1
van Blankenstein JH, Slager CJ, Soei LK, Boersma H, Stijnen T, Schuurbiers JCH, Krams R, Lachmann B et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 34 (3), 473-482.

DOI 10.1016/s0008-6363(97)00063-1

01-06-1997

True reconstruction of vessel geometry from combined X-ray angiographic and intracoronary ultrasound data.
Slager CJ, Wentzel JJ, Oomen JA, Schuurbiers JC, Krams R, von Birgelen C, Tjon A, Serruys PW et al.
Seminars in Interventional Cardiology Siic vol. 2 (1), 43-47.
01-01-1997

Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium
van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Verdouw PD, Roelandt JRTC, Bom N
Ultrasound in Medicine &Amp; Biology, Elsevier Bv vol. 23 (3), 405-414.

DOI 10.1016/s0301-5629(96)00227-x

01-01-1997

Recovery of systolic function of stunned myocardium by the Ca2+-sensitizer EMD 57033 is not accompanied by impairment of diastolic function
deZeeuw S, Soei L, vanMeegen JR, Trines SA, Krams R, Duncker DJ, Verdouw PD

01-01-1997

Stent implantation causes alterations in 3D-geometry and 3D-shear stress distribution at the endothelium of coronary arteries
Wentzel JJ, Krams R, vanBeusekom HMN, Whelan DM, vanderGeissen WJ, Krabbendam SC, Andhyiswara I, Tjien ATJ et al.

01-01-1997

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Fan DS, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, Krams R
American Journal of Physiology-Heart and Circulatory Physiology vol. 273 (5), H2146-H2154.

DOI 10.1152/ajpheart.1997.273.5.H2146

01-01-1997

1996

The effect of a thiadiazinone derived Ca2+ sensitizer on the responsiveness of Mg2+-ATPase to Ca2+ in myofibrils isolated from stunned and nonstunned porcine and human myocardium
Bezstarosti K, Soei LK, Krams R, Ten Cate FJ, Verdouw PD, Lamers JMJ
Biochemical Pharmacology, Elsevier Bv vol. 51 (9), 1211-1220.

DOI 10.1016/0006-2952(96)00083-4

01-05-1996

The relationship between myocardial integrated backscatter, perfusion pressure and wall thickness during isovolumic contraction: An isolated pig heart study
Rijsterborgh H, van der Steen AFW, Krams R, Mastik F, Lancee CT, Verdouw PD, Roelandt JRTC, Bom N
Ultrasound in Medicine &Amp; Biology, Elsevier Bv vol. 22 (1), 43-52.

DOI 10.1016/0301-5629(95)02030-6

01-01-1996

The Ca2+ sensitiser EMD 60263 only impairs diastolic function of stunned myocardium at high doses in anesthetized swine
Soei LK, Krams R, Duncker DJ, Verdouw PD

01-01-1996

1995

New invasive techniques of assessment of the physiological significance of coronary stenoses in humans
Di Mario C, Gil R, Krams R, De Feyter PJ, Serruys W
European Heart Journal, Oxford University Press (Oup) vol. 16 (suppl I), 104-114.

DOI 10.1093/eurheartj/16.suppl_i.104

02-08-1995

In Vivo Measurement of Regional Large Artery Compliance by Intravascular Ultrasound Under Pentobarbital Anesthesia
Wilson RA, Di Mario C, Krams R, Loe Kie Soei, Wenguang L, Laird AC, The SHK, Gussenhoven E et al.
Angiology, Sage Publications vol. 46 (6), 481-488.

DOI 10.1177/000331979504600604

01-06-1995

Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency
Fan D
Cardiovascular Research, Oxford University Press (Oup) vol. 29 (3), 428-437.

DOI 10.1016/0008-6363(96)88602-0

01-03-1995

734-6 ANGUS: A New Approach to Three-dimensional Reconstruction of Geometry and Orientation of Coronary Lumen and Plaque by Combined Use of Coronary Angiography and IVUS
Slager CJ, Laban M, von Birgelen C, Krams R, Oomen JAF, Boer AD, Wenguang L, de Feyter PJ et al.
Journal of The American College of Cardiology, Elsevier Bv vol. 25 (2), 144A-144A.

DOI 10.1016/0735-1097(95)92051-6

01-02-1995

SYSTEMATIC STUDY OF FLOW VELOCITY PROFILES IN EPICARDIAL CORONARY-ARTERIES OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND SUBAORTIC OUTFLOW GRADIENT
VONBIRGELEN C, KRAMS R, DIMARIO C, GIL R, KOFFLARD M, TENCATE FJ, REIMERS B, SLAGER CJ et al.

01-01-1995

HOW SHOULD WE EVALUATE THE VASODILATORY CAPACITY OF CORONARY RESISTANCE VESSELS IN PATIENTS WITH ASYMMETRIC HYPERTROPHIC CARDIOMYOPATHY
VONBIRGELEN C, KRAMS R, GIL R, TENGATE FJ, DIMARIO C

01-01-1995

1994

Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ, Verdouw PD
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 267 (4), H1557-H1564.

DOI 10.1152/ajpheart.1994.267.4.h1557

01-10-1994

Slope of the instantaneous hyperemic diastolic coronary flow velocity-pressure relation. A new index for assessment of the physiological significance of coronary stenosis in humans.
Di Mario C, Krams R, Gil R, Serruys PW
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 90 (3), 1215-1224.

DOI 10.1161/01.cir.90.3.1215

01-09-1994

Myofibrillar Ca2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium.
Soei LK, Sassen LM, Fan DS, van Veen T, Krams R, Verdouw PD
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 90 (2), 959-969.

DOI 10.1161/01.cir.90.2.959

01-08-1994

On the Reversal of Myocardial Stunning: A Role for Ca²⁺‐Sensitizers
FAN D, KIE SOEI LOE, SASSEN LMA, KRAMS ROB, HENDRIK E, VERDOUW PD
Annals of The New York Academy of Sciences, Wiley vol. 723 (1), 364-367.

DOI 10.1111/j.1749-6632.1994.tb36748.x

01-06-1994

ON THE REVERSAL OF MYOCARDIAL STUNNING - A ROLE FOR CA2+-SENSITIZERS
FAN DS, SOEI LK, SASSEN LMA, KRAMS R, HENDRIK E, VERDOUW PD
Cellular, Biochemical, and Molecular Aspects of Reperfusion Injury vol. 723, 364-367.

DOI 10.1111/j.1749-6632.1994.tb36748.x

01-01-1994

Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ, Verdouw PD
American Journal of Physiology Heart and Circulatory Physiology vol. 267 (4 36-4), H1557-H1564.

DOI 10.1152/ajpheart.1994.267.4.h1557

01-01-1994

INCREASING THE CA++ SENSITIVITY REVERSES THE INCREASED AFTERLOAD DEPENDENCY OF EXTERNAL WORK AND THE EFFICIENCY OF ENERGY-CONVERSION OF STUNNED MYOCARDIUM
FAN DS, SASSEN LMA, TRINES S, SOEI LK, KRAMS R, VERDOUW PD
Acp-Applied Cardiopulmonary Pathophysiology vol. 5 (2), 63-72.
01-01-1994

LOSS OF ELASTIC RECOIL IN POSTISCHEMIC MYOCARDIUM INDUCES RIGHTWARD SHIFT OF THE SYSTOLIC PRESSURE-VOLUME RELATIONSHIP
KRAMS R, JANSSEN M, VANDERLEE C, VANMEEGEN J, DEJONG JW, SLAGER CJ, VERDOUW PD
American Journal of Physiology-Heart and Circulatory Physiology vol. 267 (4), H1557-H1564.

DOI 10.1152/ajpheart.1994.267.4.H1557

01-01-1994

REVERSAL OF INCREASED LOAD-DEPENDENCY OF EFFICIENCY OF ENERGY-CONVERSION IN STUNNED MYOCARDIUM BY INCREASING THE CA2+ SENSITIVITY
FAN DS, KRAMS R, SOEI LK, SASSEN LMA, VERDOUW PD

01-01-1994

VARIABILITY IN OXYGEN-CONSUMPTION MEASUREMENTS DURING MYOCARDIAL STUNNING CAN BE EXPLAINED BY A PRONOUNCED AFTERLOAD DEPENDENCY OF SEGMENT LENGTH SHORTENING, EXTERNAL WORK AND MECHANICAL EFFICIENCY
FAN DS, KRAMS R, SOEI LK, SASSEN LMA, VERDOUW PD

01-01-1994

The instantaneous hyperemic pressure-flow relationship in conscious humans
Di Mario C, Krams R, Gil R, Meneveau N, Serruys PW
In Developments in Cardiovascular Medicine, Springer Netherlands 247-268.

DOI 10.1007/978-94-011-1172-0_16

01-01-1994

1993

End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation
Krams R, Soei LK, McFalls EO, Winkler Prins EA, Sassen LM, Verdouw PD
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 265 (6), H2099-H2109.

DOI 10.1152/ajpheart.1993.265.6.h2099

01-12-1993

Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia
Koning MMG, Krams R, Xiao CS, van Meegen JR, Bezstarosti K, Lamers JMJ, Verdouw PD
Cardiovascular Drugs and Therapy, Springer Science and Business Media Llc vol. 7 (5), 801-807.

DOI 10.1007/bf00878934

01-11-1993

L-Propionylcarnitine Does Not Affect Myocardial Metabolic or Functional Response to Chronotropic and Inotropic Stimulation After Repetitive Ischemia in Anesthetized Pigs
Duncker DJ, Sassen LMA, Bartels GL, van Meegen JR, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ et al.
Journal of Cardiovascular Pharmacology, Ovid Technologies (Wolters Kluwer Health) vol. 22 (3), 488-498.

DOI 10.1097/00005344-199309000-00022

01-09-1993

Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium
Krams R, Duncker DJ, McFalls EO, Hogendoorn A, Verdouw PD
Cardiovascular Research, Oxford University Press (Oup) vol. 27 (5), 740-747.

DOI 10.1093/cvr/27.5.740

01-05-1993

Altered coronary flow reserve in the hypertrophied heart: Implications for therapy
McFalls EO, Duncker DJ, Sassen LMA, Krams R, Man in't Veld AJ, Ruffolo RR, Verdouw PD
Journal of Human Hypertension vol. 7 (SUPPL. 1), S29-S36.
01-01-1993

END-SYSTOLIC PRESSURE LENGTH RELATIONS OF STUNNED RIGHT-AND-LEFT-VENTRICLES AFTER INOTROPIC STIMULATION
KRAMS R, SOEI LK, MCFALLS EO, PRINS EAW, SASSEN LMA, VERDOUW PD
American Journal of Physiology vol. 265 (6), H2099-H2109.

DOI 10.1152/ajpheart.1993.265.6.H2099

01-01-1993

CAN THE ZERO-FLOW PRESSURE BE EXTRAPOLATED FROM THE FLOW VELOCITY-PRESSURE RELATION DURING LONG DIASTOLIC PAUSES IN HUMANS
DIMARIO C, KRAMS R, BALK A, VERDOUW PD, ROELANDT J

01-01-1993

End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation
Krams R, Loe Kie Soei, McFalls EO, Prins EAW, Sassen LMA, Verdouw PD
American Journal of Physiology Heart and Circulatory Physiology vol. 265 (6 34-6), H2099-H2109.

DOI 10.1152/ajpheart.1993.265.6.h2099

01-01-1993

High-energy phosphates and their catabolites
De Jong JW, Huizer T, Janssen M, Krams R, Tavenier M, Verdouw PD
In Developments in Cardiovascular Medicine, Springer Netherlands 295-315.

DOI 10.1007/978-94-011-1713-5_13

01-01-1993

1992

Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium
McFalls EO, Duncker DJ, Krams R, Sassen LM, Hoogendoorn A, Verdouw PD
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 263 (6), H1724-H1731.

DOI 10.1152/ajpheart.1992.263.6.h1724

01-12-1992

L-propionylcarnitine and myocardial performance in stunned porcine myocardium
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ, Verdouw PD
Molecular and Cellular Biochemistry, Springer Science and Business Media Llc vol. 116 (1-2), 147-153.

DOI 10.1007/bf01270582

01-10-1992

Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium
Duncker DJ, McFalls EO, Krams R, Verdouw PD
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 262 (6), H1744-H1751.

DOI 10.1152/ajpheart.1992.262.6.h1744

01-06-1992

Inotropic stimulation restores efficiency of energy transfer from pressure-segment length area to external mechanical work in stunned porcine myocardium
Verdouw PD, Krams R, McFalls EO, Duncker DJGM, Hogendoorn A, Kie Soei L
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 24, 153-153.

DOI 10.1016/0022-2828(92)90484-h

01-05-1992

Amiodarone increases ATP and decreases ATPase activity and protein content of cultured rat heart myocytes
Bergman M, Cohen F, Schlesinger H, Kessler-Icekson G
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 24, 265-265.

DOI 10.1016/0022-2828(92)90821-g

01-05-1992

Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium
McFalls EO, Duncker DJ, Krams R, Sassen LMA, Hoogendoorn A, Verdouw PD
American Journal of Physiology Heart and Circulatory Physiology vol. 263 (6 32-6), H1724-H1731.

DOI 10.1152/ajpheart.1992.263.6.h1724

01-01-1992

PRESSURE-MAXIMAL CORONARY FLOW RELATIONSHIP IN REGIONALLY STUNNED PORCINE MYOCARDIUM
DUNCKER DJ, MCFALLS EO, KRAMS R, VERDOUW PD
American Journal of Physiology vol. 262 (6), H1744-H1751.

DOI 10.1152/ajpheart.1992.262.6.H1744

01-01-1992

RECRUITMENT OF MYOCARDIAL WORK AND METABOLISM IN REGIONALLY STUNNED PORCINE MYOCARDIUM
MCFALLS EO, DUNCKER DJ, KRAMS R, SASSEN LMA, HOOGENDOORN A, VERDOUW PD
American Journal of Physiology vol. 263 (6), H1724-H1731.

DOI 10.1152/ajpheart.1992.263.6.H1724

01-01-1992

Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium
Duncker DJ, McFalls EO, Krams R, Verdouw PD
American Journal of Physiology Heart and Circulatory Physiology vol. 262 (6 31-6), H1744-H1751.

DOI 10.1152/ajpheart.1992.262.6.h1744

01-01-1992

RECRUITMENT OF REGIONAL EXTERNAL WORK AND OXYGEN-CONSUMPTION IN STUNNED PORCINE MYOCARDIUM
MCFALLS EO, KRAMS R, DUNCKER DJ, SASSEN LMA, HOOGENDOORN A, VERDOUW PD

01-01-1992

L-propionylcarnitine and myocardial performance in stunned porcine myocardium
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ, Verdouw PD
In Lipid Metabolism in The Healthy and Disease Heart, Springer Us 147-153.

DOI 10.1007/978-1-4615-3514-0_21

01-01-1992

1991

Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine
McFalls EO, Duncker DJ, Krams R, Ward H, Gornick C, Verdouw PD
Cardiovascular Research, Oxford University Press (Oup) vol. 25 (8), 659-665.

DOI 10.1093/cvr/25.8.659

01-08-1991

Changes in oxygen-pressure volume area's (O2-PVA) studied after brief periods of ischemia
KRAMS R
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 23, S22-S22.

DOI 10.1016/0022-2828(91)90585-a

01-07-1991

Elastic recoil: A sensitive measure of loss of function during brief periods of ischemia and reperfusion
KRAMS R
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 23, S23-S23.

DOI 10.1016/0022-2828(91)90588-d

01-07-1991

Does intravenous milrinone have a direct effect on diastolic function?
Krams R, McFalls E, van der Giessen WJ, Serruys PW, Verdoun PD, Roelandt J
American Heart Journal, Elsevier Bv vol. 121 (6), 1951-1955.

DOI 10.1016/0002-8703(91)90831-2

01-06-1991

DOES INTRAVENOUS MILRINONE HAVE A DIRECT EFFECT ON DIASTOLIC FUNCTION
KRAMS R, MCFALLS E, VANDERGIESSEN WJ, SERRUYS PW, VERDOUN PD, ROELANDT J

DOI 10.1016/0002-8703(91)90831-2

01-01-1991

THE EFFECT OF MILRINONE ON DIASTOLIC FUNCTION - DIRECT OR INDIRECT EFFECT
KRAMS R, MCFALLS E, VANDERGIESSEN WJ, SERRUYS PW, ROELANDT J

01-01-1991

Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine
Mcfalls EO, Duncker DJ, Krams R, Ward H, Gornick C, Verdouw PD
Cardiovascular Research vol. 25 (8), 659-665.

DOI 10.1093/cvr/25.8.659

01-01-1991

1990

Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R, Yin FC
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 259 (6), H1869-H1880.

DOI 10.1152/ajpheart.1990.259.6.h1869

01-12-1990

Myocardial modulation of coronary circulation Reply)
Westerhof N, Sipkema P, Krams R
American Journal of Physiology Heart and Circulatory Physiology vol. 259 (6 28-6), H1936-H1937.
01-12-1990

Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure
Krams R, Sipkema P, Westerhof N
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 258 (6), H1889-H1898.

DOI 10.1152/ajpheart.1990.258.6.h1889

01-06-1990

MYOCARDIAL MODULATION OF CORONARY CIRCULATION - REPLY
WESTERHOF N, SIPKEMA P, KRAMS R
American Journal of Physiology vol. 259 (6), H1936-H1937.
01-01-1990

EFFECT OF WALL STRETCH ON CORONARY HEMODYNAMICS IN ISOLATED CANINE INTERVENTRICULAR SEPTUM
RESAR J, LIVINGSTON JZ, HALPERIN HR, SIPKEMA P, KRAMS R, YIN FCP
American Journal of Physiology vol. 259 (6), H1869-H1880.

DOI 10.1152/ajpheart.1990.259.6.H1869

01-01-1990

CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE
KRAMS R, SIPKEMA P, WESTERHOF N
American Journal of Physiology vol. 258 (6), H1889-H1898.

DOI 10.1152/ajpheart.1990.258.6.H1889

01-01-1990

Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R, Yin FCP
American Journal of Physiology Heart and Circulatory Physiology vol. 259 (6 28-6), H1869-H1880.

DOI 10.1152/ajpheart.1990.259.6.h1869

01-01-1990

Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure
Krams R, Sipkema P, Westerhof N
American Journal of Physiology Heart and Circulatory Physiology vol. 258 (6 27-6), H1889-H1898.

DOI 10.1152/ajpheart.1990.258.6.h1889

01-01-1990

1989

Contractility is the main determinant of coronary systolic flow impediment
Krams R, Sipkema P, Zegers J, Westerhof N
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 257 (6), H1936-H1944.

DOI 10.1152/ajpheart.1989.257.6.h1936

01-12-1989

Varying elastance concept may explain coronary systolic flow impediment
Krams R, Sipkema P, Westerhof N
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 257 (5), H1471-H1479.

DOI 10.1152/ajpheart.1989.257.5.h1471

01-11-1989

Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance?
Krams R, Haelst ACTA, Sipkema P, Westerhof N
Basic Research in Cardiology, Springer Science and Business Media Llc vol. 84 (2), 149-159.

DOI 10.1007/bf01907924

01-03-1989

VARYING ELASTANCE CONCEPT MAY EXPLAIN CORONARY SYSTOLIC FLOW IMPEDIMENT
KRAMS R, SIPKEMA P, WESTERHOF N
American Journal of Physiology vol. 257 (5), H1471-H1479.

DOI 10.1152/ajpheart.1989.257.5.H1471

01-01-1989

CONTRACTILITY IS THE MAIN DETERMINANT OF CORONARY SYSTOLIC FLOW IMPEDIMENT
KRAMS R, SIPKEMA P, ZEGERS J, WESTERHOF N
American Journal of Physiology vol. 257 (6), H1936-H1944.

DOI 10.1152/ajpheart.1989.257.6.H1936

01-01-1989

1988

Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion
Van Dijk LC, Krams R, Sipkema P, Westerhof N
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 255 (3), H476-H482.

DOI 10.1152/ajpheart.1988.255.3.h476

01-09-1988

EFFECTS OF STRETCH ON THE PRESSURE-FLOW RELATION OF THE ISOLATED ARRESTED DOG SEPTUM
YIN F, SIPKEMA P, KRAMS R, STRUMPF R, RESAR J

01-01-1988

CHANGES IN CORONARY PRESSURE-FLOW RELATION AFTER TRANSITION FROM BLOOD TO TYRODE PERFUSION
VANDIJK LC, KRAMS R, SIPKEMA P, WESTERHOF N
American Journal of Physiology vol. 255 (3), H476-H482.

DOI 10.1152/ajpheart.1988.255.3.H476

01-01-1988

SYSTOLIC CORONARY FLOW IMPEDIMENT EXPLAINED ON BASIS OF THE TIME-VARYING ELASTANCE CONCEPT
SIPKEMA P, KRAMS R, WESTERHOF N

01-01-1988

1986

Comments on \Pressure and tone dependence of coronary diastolic input impedance and capacitance\
Westerhof N, Krams R
American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society vol. 250 (2), H330-H331.

DOI 10.1152/ajpheart.1986.250.2.h330

01-02-1986

PRESSURE AND TONE DEPENDENCE OF CORONARY DIASTOLIC INPUT IMPEDANCE AND CAPACITANCE - COMMENT
WESTERHOF N, KRAMS R
American Journal of Physiology vol. 250 (2), H330-H330.

DOI 10.1152/ajpheart.1986.250.2.H330

01-01-1986

Comments on 'pressure and tone dependence of coronary diastolic input impedance and capacitance'
Westerhof N, Krams R, Canty JM
American Journal of Physiology Heart and Circulatory Physiology vol. 250 (2 (19/2)), H330-H331.

DOI 10.1152/ajpheart.1986.250.2.h330

01-01-1986

1985

DOES LEFT-VENTRICULAR PRESSURE INFLUENCE THE CORONARY PRESSURE-FLOW RELATION IN THE CAT
KRAMS R, SIPKEMA P, WESTERHOF N

01-01-1985

1984

EFFECTS OF CARDIAC CONTRACTION ON CORONARY FLOW.
Sipkema P, Burattini R, van Haelst ACTA, Krams R, Westerhof N

01-12-1984

\Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog\.
Borgdorff P, Braakman R, van Haelst AC, van Huis GA, de Jong JP, Krams R, Langewouters GJ, Sipkema P et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 54 (3), 348-348.

DOI 10.1161/01.res.54.3.348

01-03-1984

CAN LEFT-VENTRICULAR PRESSURE EXPLAIN CORONARY FLOW IMPEDIMENT
WESTERHOF N, KRAMS R, VANHAELST A, SIPKEMA P

01-01-1984

1982

THE EFFECTS OF THE CORONARY CAPACITANCE ON THE INTERPRETATION OF DIASTOLIC PRESSURE-FLOW RELATIONSHIPS - COMMENTS
BRAAKMAN R, VANDERHORN GJ, VONHUIS GA, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P, WESTERHOF N
Circulation Research vol. 51 (6), 822-822.
01-01-1982

Intravascular ultrasound tissue harmonic imaging in vivo
Frijlink ME, Goertz DE, van Damme LCA, Krams R, van der Steen AFW
IEEE Ultrasonics Symposium, 2004.

DOI 10.1109/ultsym.2004.1417976

On the numerical analysis of coronary artery wall shear stress
Wolters BJBM, Slager CJ, Gijsen FJH, Wentze JJ, Krams R, van de Vossel FN
Computers in Cardiology 2001. Vol.28.

DOI 10.1109/cic.2001.977618

Towards assessment of regional wall stress of the left ventricle using 3D ultrasound imaging
Oomen JA, Trines SAIP, Vermeulen WB, Krams R, Schuurbiers JCH, Vletter WB, Roelandt JRTC, Slager CJ
Computers in Cardiology 1999. Vol. 26.

DOI 10.1109/cic.1999.825923

ANGUS: a new approach to three-dimensional reconstruction of coronary vessels by combined use of angiography and intravascular ultrasound
Laban M, Oomen JA, Slager CJ, Wentzel JJ, Krams R, Schuurbiers JCH, den Beer A, von Birgelen C et al.
Computers in Cardiology 1995.

DOI 10.1109/cic.1995.482638

Disturbance of 3D velocity profiles induced by an IVUS catheter: evaluation with computational fluid dynamics
Wentzel JJ, Krams R, van der Steen AFW, Li W, Cespedes E, Bom N, Slager CJ
Computers in Cardiology 1997.

DOI 10.1109/cic.1997.648024

Novel developments in intravascular imaging
van der Steen AFW, Cespedes EI, de Korte CL, Carlier SG, Li W, Mastik F, Lancee CT, Borsbroom J et al.
1998 IEEE Ultrasonics Symposium. Proceedings.

DOI 10.1109/ultsym.1998.765284

Applying computational fluid dynamics to a spatially correct 3D reconstruction of a coronary arterial segment in the individual patient
Wentzel JJ, Krams R, Oomen JAF, Schuurbiers JCH, Vinke R, Bom N, Slager CJ
18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

DOI 10.1109/iembs.1996.652826

A modular hard and software system for the analysis of cardiac signals: application to real time pressure-volume loops
Bruining N, Krams R, Passchier H, Meij S, de Feijter P, Keane D
Computers in Cardiology Conference.

DOI 10.1109/cic.1993.378479

Grants

G1F1Application of a new high throughput platform for validation of mechanosensitive miRNA
Rob Krams and Gleb Sukhorukov
£117,986 British Heart Foundation
01-09-2023 - 31-08-2026

Inorganic nitrate treatment reduces inflammation in humans: assessment of mechanisms
Amrita Ahluwalia, Rob Krams, Federica Marelli-Berg and Jacqueline Cooper
£206,297 British Heart Foundation
19-08-2019 - 18-02-2022

Biomechanical determinants of advanced coronary atherosclerotic plaque formation in transgenic hyperlipidaemic minipigs
Rob Krams
£167,563 British Heart Foundation
01-11-2018 - 31-01-2021

Disturbed shear stress and strain act synergistically to promote the pro-atherogenic endothelial cell phenotype responsible for TCFA - GRANT TRANSFER
Rob Krams
£46,226 British Heart Foundation
01-02-2018 - 16-08-2018

Aliah Mohammed Ahmad Abuammah - Studentship
Rob Krams
£28,000 Saudi Arabian Cultural Bureau in London
22-01-2018 - 12-01-2019