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Prof Rob Krams

Rob Krams

Professor

School of Engineering and Materials Science
Queen Mary University of London
07972 413211

www.sems.qmul.ac.uk/staff/r.krams

Research

Interests

Interested in evaluating miRNA as a new treatment for atherosclerosis. We predict (bioinformatics) and test (high throughput) new miRNA in animal models of atherosclerosis

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Krams IA, Luoto S, Krama T, Krams R, Sieving K, Trakimas G, Elferts D, Rantala MJ and Goodale E (2020). Egalitarian mixed-species bird groups enhance winter survival of subordinate group members but only in high-quality forests. Scientific Reports  vol. 10, (1) 10.1038/s41598-020-60144-w
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L and Stone GW (2020). Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events. Jacc: Cardiovascular Imaging  10.1016/j.jcmg.2020.02.028
Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R, Botnar R and Long NJ (2020). Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque. Nanotheranostics  vol. 4, (4) 184-194. 10.7150/ntno.44712

2019

Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J, Edelman E, Evans P, van der Heiden K, Hose R, Koo B-K, Krams R, Marsden A, Migliavacca F, Onuma Y, Ooi A, Poon E, Samady H, Stone P, Takahashi K, Tang D, Thondapu V, Tenekecioglu E, Timmins L, Torii R, Wentzel J and Serruys P (2019). Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications. Oxford University Press (Oup)  European Heart Journal  10.1093/eurheartj/ehz551
Mohri Z, Del Rio Hernandez A and Krams R (2019). The emerging role of YAP/TAZ in mechanotransduction. J Thorac Dis  vol. 9, (5) E507-E509. 10.21037/jtd.2017.03.179
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR, Bijlenga P, Cuhlmann S, Evans P, Kwak BR, Ventikos Y and Krams R (2019). Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo. Sci Rep  vol. 9, (1) 4738-4738. 10.1038/s41598-019-40959-y
Poulsen CB, Pedrigi RM, Pareek N, Kilic ID, Holm NR, Bentzon JF, Bøtker HE, Falk E, Krams R and de Silva R (2019). Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis. Eurointervention  vol. 14, (10) 1129-1135. 10.4244/EIJ-D-17-01028

2018

Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys C and Krams R (2018). New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress. Current Opinion in Biomedical Engineering  vol. 5, 96-104. 10.1016/j.cobme.2018.03.003

2017

Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T, Saliba D, Goddard ME, Sansom SN, Goncalves I, Krams R, Udalova IA and Monaco C (2017). Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis. American Heart Association, Inc  Circulation  vol. 136, (12) 1140-1154. 10.1161/CIRCULATIONAHA.117.027844
Denis J-F, Scheckenbach KEL, Pfenniger A, Meens MJ, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak BR (2017). Connexin40 controls endothelial activation by dampening NFκB activation. Impact Journals  Oncotarget  vol. 8, (31) 50972-50986. 10.18632/oncotarget.16438

2016

Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton J-P, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJA and Evans PC (2016). Zebrafish Model for Functional Screening of Flow-Responsive Genes. Wolters Kluwer Health, Inc  Arterioscler Thromb Vasc Biol  vol. 37, (1) 130-143. 10.1161/ATVBAHA.116.308502
Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Baeriswyl DC, Drakakis EM and Krams R (2016). Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB. Springer Nature  Ann Biomed Eng  vol. 45, (4) 898-909. 10.1007/s10439-016-1750-z
Pedrigi RM, Mehta V, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, De Silva R, Petretto E and Krams R (2016). Influence of shear stress magnitude and direction on atherosclerotic plaque composition. Royal Society Open Science  vol. 3, (10) 10.1098/rsos.160588
Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L, Pedrigi RM, Homma T and Krams R (2016). Development of a synthetic gene network to modulate gene expression by mechanical forces. Springer Nature  Sci Rep  vol. 6, 29643-29643. 10.1038/srep29643
Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M and Krams R (2016). Comparison between direct and reverse electroporation of cells in situ: A simulation study. Physiological Reports  vol. 4, (6) 1-14. 10.14814/phy2.12673
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C (2016). Corrigendum to Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques [J Mol Cell Cardiol, 89B (2015) 168-172]. Journal of Molecular and Cellular Cardiology  vol. 91, 10.1016/j.yjmcc.2015.12.029
Maimari N, Pedrigi RM, Russo A, Broda K and Krams R (2016). Integration of flow studies for robust selection of mechanoresponsive genes. Thrombosis and Haemostasis  vol. 115, (3) 474-483. 10.1160/TH15-09-0704

2015

Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C (2015). Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques. Journal of Molecular and Cellular Cardiology  vol. 89, 168-172. 10.1016/j.yjmcc.2015.10.034
Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, De Silva R, Paterson C, Krams R and Török P (2015). Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma. Journal of The Royal Society Interface  vol. 12, (112) 10.1098/rsif.2015.0843
Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV, Krams R and Kwak BR (2015). Shear stress-induced atherosclerotic plaque composition in ApoE-/- mice is modulated by connexin37. Atherosclerosis  vol. 243, (1) 1-10. 10.1016/j.atherosclerosis.2015.08.029
Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R and Choi JJ (2015). Enhancement of Non-Invasive Trans-Membrane Drug Delivery Using Ultrasound and Microbubbles During Physiologically Relevant Flow. Ultrasound in Medicine and Biology  vol. 41, (9) 2435-2448. 10.1016/j.ultrasmedbio.2015.05.003
Dent MR, López-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA, Brooks NJ and Kuimova MK (2015). Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors. Physical Chemistry Chemical Physics  vol. 17, (28) 18393-18402. 10.1039/c5cp01937k
Kis Z, Pereira HSA, Homma T, Pedrigi RM and Krams R (2015). Mammalian synthetic biology: Emerging medical applications. Journal of The Royal Society Interface  vol. 12, (106) 10.1098/rsif.2014.1000
(2015). Inducing persistent flow disturbances accelerates atherogenesis and promotes thin cap fibroatheroma development in D374Y-PCSK9 hypercholesterolemic minipigs. Circulation  vol. 132, (11) 1003-1012. 10.1161/CIRCULATIONAHA.115.016270

2014

Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ and Weinberg PD (2014). Elevated uptake of plasma macromolecules by regions of arterial wall predisposed to plaque instability in a mouse model. Plos One  vol. 9, (12) 10.1371/journal.pone.0115728
Maimari N, Broda K, Kakas A, Krams R and Russo A (2014). Symbolic Representation and Inference of Regulatory Network Structures. Logical Modeling of Biological Systems  10.1002/9781119005223.ch1
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC (2014). In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106. Mol Imaging  vol. 13, (6) 10.2310/7290.2014.00014
Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P and Coppola G (2014). Erratum: Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: Influence of intraluminal flow (Journal of the Royal Society Interface (2013) 10, (20130578) DOI: 10.1098/rsif.2013.0578). Journal of The Royal Society Interface  vol. 11, (92) 10.1098/rsif.2013.1156
Cuhlmann S, Gsell W, Van Der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC (2014). In vivo mapping of vascular inflammation using the translocator protein tracer 18F-FEDAA1106. Molecular Imaging  vol. 13, (6) 10.2310/7290.2014.00014
Pedrigi RM, De Silva R, Bovens SM, Mehta VV, Petretto E and Krams R (2014). Thin-cap fibroatheroma rupture is associated with a fine interplay of shear and wall stress. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 34, (10) 2224-2231. 10.1161/ATVBAHA.114.303426
Kwak BR, Bäck M, Bochaton-Piallat ML, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ and Evans PC (2014). Biomechanical factors in atherosclerosis: Mechanisms and clinical implications. European Heart Journal  vol. 35, (43) 3013-3020. 10.1093/eurheartj/ehu353
Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A and Krams R (2014). An In situ electroporation and flow device for mechanotransduction studies. Microarrays: Principles, Applications and Technologies 

2013

Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Coppola G and Gilson P (2013). Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: Influence of intraluminal flow. Journal of The Royal Society Interface  vol. 10, (89) 10.1098/rsif.2013.0578
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C and Tokgözoglu L (2013). Stabilization of atherosclerotic plaques: An update. European Heart Journal  vol. 34, (42) 3251-3258. 10.1093/eurheartj/eht301
Foin N, Sen S, Petraco R, Nijjer S, Torii R, Kousera C, Broyd C, Mehta V, Xu Y, Mayet J, Hughes A, Di Mario C, Krams R, Francis D and Davies J (2013). Method for percutaneously introducing, and removing, anatomical stenosis of predetermined severity in vivo: The stenotic stent. Journal of Cardiovascular Translational Research  vol. 6, (4) 640-648. 10.1007/s12265-013-9476-x
Frueh J, Maimari N, Homma T, Bovens SM, Pedrigi RM, Towhidi L and Krams R (2013). Systems biology of the functional and dysfunctional endothelium. Cardiovascular Research  vol. 99, (2) 334-341. 10.1093/cvr/cvt108
Olivon VC, Fraga-Silva RA, Segers D, Demougeot C, de Oliveira AM, Savergnini SS, Berthelot A, de Crom R, Krams R, Stergiopulos N and da Silva RF (2013). Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE-/- mice. Atherosclerosis  vol. 227, (2) 236-243. 10.1016/j.atherosclerosis.2012.12.014
Harrison M, Smith E, Ross E, Krams R, Segers D, Buckley CD, Nash GB and Rainger GE (2013). The role of platelet-endothelial cell adhesion molecule-1 in atheroma formation varies depending on the site-specific hemodynamic environment. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 33, (4) 694-701. 10.1161/ATVBAHA.112.300379
Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J, Oldberg A and Hultgårdh-Nilsson A (2013). Fibromodulin deficiency reduces low-density lipoprotein accumulation in atherosclerotic plaques in apolipoprotein E-null mice. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 33, (2) 354-361. 10.1161/ATVBAHA.112.300723

2012

Da Silva RF, Gambillara V, Krams R and Stergiopulos N (2012). Modulation of arginases by different patterns of shear stress: New signaling pathway in atherogenesis? Computer Methods in Biomechanics and Biomedical Engineering  vol. 10, (SUPPL. 1) 77-78. 10.1080/10255840701478497
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC, Krams R and Kwak BR (2012). Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells. Journal of Molecular and Cellular Cardiology  vol. 53, (2) 299-309. 10.1016/j.yjmcc.2012.05.011
Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E, Falck-Hansen M, Bovens S, Pedrigi R, Homma T, Coppola G and Krams R (2012). Systems and synthetic biology of the vessel wall. Febs Letters  vol. 586, (15) 2164-2170. 10.1016/j.febslet.2012.04.031
Van Bochove GS, Sanders HMHF, De Smet M, Keizer HM, Mulder WJM, Krams R, Strijkers GJ and Nicolay K (2012). Molecular MR imaging of collagen in mouse atherosclerosis by using paramagnetic CNA35 micelles. European Journal of Inorganic Chemistry  (12) 2115-2125. 10.1002/ejic.201200010
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M (2012). Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice. Journal of Visualized Experiments  (59) 1-6. 10.3791/3308
Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Chan PH, Davies JE, Xu XY, Krams R and Di Mario C (2012). Kissing balloon or sequential dilation of the side branch and main vessel for provisional stenting of bifurcations: Lessons from micro-computed tomography and computational simulations. Jacc: Cardiovascular Interventions  vol. 5, (1) 47-56. 10.1016/j.jcin.2011.08.019

2011

Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H, Krams R and Evans PC (2011). (18)FEDAA is a more specific probe than (18)FDG for imaging vascular inflammation. European Journal of Nuclear Medicine and Molecular Imaging  vol. 38, S210-S210.
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R, Lawford PV, Lishchuk SV, Pontrelli G, Ridger V, Spencer TJ, Ventikos Y, Walker DC and Watton PN (2011). Multi-scale interaction of particulate flow and the artery wall. Medical Engineering and Physics  vol. 33, (7) 840-848. 10.1016/j.medengphy.2010.09.007
Foin N, Secco GG, Ghilencea L, Krams R and Di Mario C (2011). Final proximal post-dilatation is necessary after kissing balloon in bifurcation stenting. Eurointervention  vol. 7, (5) 597-604. 10.4244/EIJV7I5A96
Foin N, Viceconte N, Chan PH, Lindsay AC, Krams R and Di Mario C (2011). Jailed side branches: Fate of unapposed struts studied with 3D frequency-domain optical coherence tomography. Journal of Cardiovascular Medicine  vol. 12, (8) 581-582. 10.2459/JCM.0b013e32834916e3
De Crom R, Leenen P, Nicolay K and Krams R (2011). Shear stress is a major determinant for getting a heart attack. Hart Bulletin  vol. 42, (3) 67-70.
Cuhlmann S, Van Der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R and Evans PC (2011). Disturbed blood flow induces rela expression via c-Jun N-terminal kinase 1: A novel mode of NF-κB regulation that promotes arterial inflammation. Circulation Research  vol. 108, (8) 950-959. 10.1161/CIRCRESAHA.110.233841
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N, Athanasiou T, Leen ELS, Mason JC, Haskard DO and Evans PC (2011). Dexamethasone arterializes venous endothelial cells by inducing mitogen-activated protein kinase phosphatase-1: A novel antiinflammatory treatment for vein grafts? Circulation  vol. 123, (5) 524-532. 10.1161/CIRCULATIONAHA.110.979542
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Wouter Jukema J, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C and Tokgözoglu L (2011). Stabilisation of atherosclerotic plaques position paper of the european society of cardiology (ESC) working group on atherosclerosis and vascular biology. Thrombosis and Haemostasis  vol. 106, (1) 1-19. 10.1160/TH10-12-0784
Segers D, Lipton JA, Leenen PJM, Cheng C, Tempel D, Pasterkamp G, Moll FL, de Crom R and Krams R (2011). Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans. Int J Inflam  vol. 2011, 10.4061/2011/936109
Van Bochove GS, Paulis LEM, Segers D, Mulder WJM, Krams R, Nicolay K and Strijkers GJ (2011). Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque. Contrast Media and Molecular Imaging  vol. 6, (1) 35-45. 10.1002/cmmi.402

2010

Debernardi N, Roijers RB, Krams R, De Crom R, Mutsaers PHA and Van Der Vusse GJ (2010). Microcalcifications in atherosclerotic lesion of apolipoprotein E-deficient mouse. International Journal of Experimental Pathology  vol. 91, (6) 485-494. 10.1111/j.1365-2613.2010.00729.x
Plata AM, Sherwin SJ and Krams R (2010). Endothelial nitric oxide production and transport in flow chambers: The importance of convection. Annals of Biomedical Engineering  vol. 38, (9) 2805-2816. 10.1007/s10439-010-0039-x
Krams R, Cuhlmann S, Foin N and Evans P (2010). Shear stress, inflammation and Atherosclerosis. Artery Research  vol. 4, (2) 41-46. 10.1016/j.artres.2010.03.002
Van Bochove GS, Straathof R, Krams R, Nicolay K and Strijkers GJ (2010). MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque. Magnetic Resonance Materials in Physics, Biology and Medicine  vol. 23, (2) 77-84. 10.1007/s10334-010-0200-4
Friedman MH, Krams R and Chandran KB (2010). Flow interactions with cells and tissues: Cardiovascular flows and fluid-structure interactions: Sixth international bio-fluid mechanics symposium and workshop, March 28-30, 2008, Pasadena, California. Annals of Biomedical Engineering  vol. 38, (3) 1178-1187. 10.1007/s10439-010-9900-1
Helderman F, Manoch IJ, Breeuwer , Kose U, Boersma H, Van Sambeek MRHM, Pattynama PMT, SchoutenO. , Poldermans D, WisselinkW. , Van Der Steen AFW and Krams R (2010). Predicting patient-specific expansion of abdominal aortic aneurysms. European Journal of Vascular and Endovascular Surgery  vol. 40, (1) 47-53. 10.1016/j.ejvs.2010.02.017
Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, Van Der Heiden K, Luong LA, Davis J, Platt A, Mason JC, Krams R, Haskard DO, Clark AR and Evans PC (2010). C-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 30, (3) 546-553. 10.1161/ATVBAHA.109.201368

2009

Zakkar M, Van Der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC and Evans PC (2009). Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 29, (11) 1851-1857. 10.1161/ATVBAHA.109.193375
de Crom R, Cheng C, Helderman F and Krams R (2009). Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis  vol. 204, (1) 16-17. 10.1016/j.atherosclerosis.2008.08.010
Cheng C, Tempel D, van Haperen R, van Damme L, Algür M, Krams R and de Crom R (2009). Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype. Atherosclerosis  vol. 204, (1) 26-33. 10.1016/j.atherosclerosis.2009.01.025
Susa D, van de Engel S, van Damme LCA, Roest HP, Krams R, IJzermans JNM and de Bruin RWF (2009). Donor pre-treatment with tacrolimus reduces transplant vasculopathy. Pharmacological Research  vol. 59, (4) 273-278. 10.1016/j.phrs.2008.12.006
Foin N, Plata-Garcia A, Cuhlmann S, Evans P, Caro C and Krams R (2009). SHEAR STRESS AND MASS TRANSPORT AFFECTS NF kappa B DYNAMICS IN ENDOTHELIAL CELLS. Journal of Physiological Sciences  vol. 59, 324-324.

2008

Segers D, Weinberg P and Krams R (2008). Atherosclerosis: Cell biology and lipoproteins - Shear stress and inflammation in plaque formation: New evidence. Current Opinion in Lipidology  vol. 19, (6) 627-628. 10.1097/MOL.0b013e328318db32
Krams R, Breeuwer M and van de Vosse F (2008). Personalised imaging and biomechanical modelling of large vessels. Medical and Biological Engineering and Computing  vol. 46, (11) 1057-1058. 10.1007/s11517-008-0417-9
Robbers-Visser D, Helderman F, Strengers JL, Van Osch-Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R and Helbing WA (2008). Pulmonary artery size and function after fontan operation at a young age. Journal of Magnetic Resonance Imaging  vol. 28, (5) 1101-1107. 10.1002/jmri.21544
Ridger V, Krams R, Carpi A and Evans PC (2008). Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update. Biomedicine and Pharmacotherapy  vol. 62, (8) 536-540. 10.1016/j.biopha.2008.07.053
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO and Evans PC (2008). Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis. Circulation Research  vol. 103, (7) 726-732. 10.1161/CIRCRESAHA.108.183913
Breeuwer M, de Putter S, Kose U, Speelman L, Visser K, Gerritsen F, Hoogeveen R, Krams R, van den Bosch H, Buth J, Gunther T, Wolters B, van Dam E and van de Vosse F (2008). Towards patient-specific risk assessment of abdominal aortic aneurysm. Medical and Biological Engineering and Computing  vol. 46, (11) 1085-1095. 10.1007/s11517-008-0393-0
Helderman F, Manoch IJ, Breeuwer M, Kose U, Schouten O, Sambeek MRM, Poldermans D, Pattynama PTM, Wisselink W, Steen AFW and Krams R (2008). A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness. Medical and Biological Engineering and Computing  vol. 46, (11) 1121-1127. 10.1007/s11517-008-0358-3
Cheng C, Tempel D, Oostlander A, Helderman F, Gijsen F, Wentzel J, Van Haperen R, Haitsma DB, Serruys PW, Van Der Steen AFW, De Crom R and Krams R (2008). Rapamycin modulates the eNOS vs. shear stress relationship. Cardiovascular Research  vol. 78, (1) 123-129. 10.1093/cvr/cvm103
Van der Heiden K, Hierck BP, Krams R, de Crom R, Cheng C, Baiker M, Pourquie MJBM, Alkemade FE, DeRuiter MC, Gittenberger-de Groot AC and Poelmann RE (2008). Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis. Atherosclerosis  vol. 196, (2) 542-550. 10.1016/j.atherosclerosis.2007.05.030
Foin N, Evans P and Krams R (2008). Atherosclerosis: Cell biology and lipoproteins - New developments in imaging of inflammation of the vulnerable plaque. Current Opinion in Lipidology  vol. 19, (1) 98-100. 10.1097/MOL.0b013e3282f41b60
Segers D, Garcia-Garcia HM, Cheng C, De Crom R, Krams R, Wentzel JJ, Van der Steen AFW, Serruys PW, Leenen PJM and Laman JD (2008). A primer on the immune system in the pathogenesis and treatment of atherosclerosis. Eurointervention  vol. 4, (3) 378-390. 10.4244/EIJV4I3A67

2007

Goertz DE, Frijlink ME, Tempel D, Bhagwandas V, Gisolf A, Krams R, de Jong N and van der Steen AFW (2007). Subharmonic Contrast Intravascular Ultrasound for Vasa Vasorum Imaging. Ultrasound in Medicine and Biology  vol. 33, (12) 1859-1872. 10.1016/j.ultrasmedbio.2007.05.023
Cheng C, Helderman F, Tempel D, Segers D, Hierck B, Poelmann R, van Tol A, Duncker DJ, Robbers-Visser D, Ursem NTC, van Haperen R, Wentzel JJ, Gijsen F, van der Steen AFW, de Crom R and Krams R (2007). Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis  vol. 195, (2) 225-235. 10.1016/j.atherosclerosis.2006.11.019
Helderman F, Segers D, De Crom R, Hierck BP, Poelmann RE, Evans PC and Krams R (2007). Effect of shear stress on vascular inflammation and plaque development. Current Opinion in Lipidology  vol. 18, (5) 527-533. 10.1097/MOL.0b013e3282ef7716
Jackson CL, Bennett MR, Biessen EAL, Johnson JL and Krams R (2007). Assessment of unstable atherosclerosis in mice. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 27, (4) 714-720. 10.1161/01.ATV.0000261873.86623.e1
Cheng C, Tempel D, Van Haperen R, De Boer HC, Segers D, Huisman M, Van Zonneveld AJ, Leenen PJM, Van Der Steen A, Serruys PW, De Crom R and Krams R (2007). Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. Journal of Clinical Investigation  vol. 117, (3) 616-626. 10.1172/JCI28180
Segers D, Helderman F, Cheng C, Van Damme LCA, Tempel D, Boersma E, Serruys PW, De Crom R, Van Der Steen AFW, Holvoet P and Krams R (2007). Gelatinolytic activity in atherosclerotic plaques is highly localized and is associated with both macrophages and smooth muscle cells in vivo. Circulation  vol. 115, (5) 609-616. 10.1161/CIRCULATIONAHA.106.636415
Goertz DE, Frijlink ME, Krams R, De Jong N and Van Der Steen AFW (2007). Vasa vasorum and molecular imaging of atherosclerotic plaques using nonlinear contrast intravascular ultrasound. Netherlands Heart Journal  vol. 15, (2) 77-80. 10.1007/BF03085959
Kofflard MJ, Michels M, Krams R, Kliffen M, Geleijnse ML, Ten Cate FJ and Serruys PW (2007). Coronary flow reserve in hypertrophic cardiomyopathy: Relation with microvascular dysfunction and pathophysiological characteristics. Netherlands Heart Journal  vol. 15, (6) 209-215. 10.1007/BF03085982
Wentzel JJ, Gijsen FJH, Krams R, de Crom R, Cheng C, Groen HC, Van Der Giessen AG, Van Der Steen AFW and Serruys PW (2007). Shear stress and the vulnerable plaque. Handbook of The Vulnerable Plaque, Second Edition 

2006

Krams R, Schaar J, Helderman F, Cheng C, Gourabi BM, Van Damme LCA, Segers D, Regar E, Slager CJ, De Feyter PJ, Van Der Steen AFW and Serruys PW (2006). Visualization of the vulnerable plaque. Cardiovascular Research: New Technologies, Methods, and Applications  10.1007/0-387-23329-6_12
Frijlink ME, Goertz DE, Vos HJ, Tesselaar E, Blacquière G, Gisolf A, Krams R and van der Steen AFW (2006). Harmonic intravascular ultrasound imaging with a dual-frequency catheter. Ultrasound in Medicine and Biology  vol. 32, (11) 1649-1654. 10.1016/j.ultrasmedbio.2006.05.024
Cheng C, Tempel D, Van Der Baan A, Krams R, Daemen MJAP, Van Haperen R, Grosveld F and De Crom R (2006). Response to letter regarding article, atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress [2]. Circulation  vol. 114, (22) 10.1161/CIRCULATIONAHA.106.658302
Frijlink ME, Goertz DE, Van Damme LCA, Krams R and Van Der Steen AFW (2006). Intravascular ultrasound tissue harmonic imaging in vivo. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control  vol. 53, (10) 1844-1851. 10.1109/TUFFC.2006.116
Goertz DE, Frijlink ME, Tempel D, Van Damme LCA, Krams R, Schaar JA, Ten Cate FJ, Serruys PW, De Jong N and Van Der Steen AFW (2006). Contrast harmonic intravascular ultrasound: A feasibility study for vasa vasorum imaging. Investigative Radiology  vol. 41, (8) 631-638. 10.1097/01.rli.0000229773.11715.da
Krams R, Cheng C, Helderman F, Verheye S, van Damme LCA, Mousavi Gourabi B, Tempel D, Segers D, de Feyter P, Pasterkamp G, De Klein D, de Crom R, van der Steen AFW and Serruys PW (2006). Shear stress is associated with markers of plaque vulnerability and MMP-9 activity. Eurointervention  vol. 2, (2) 250-256.
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R and de Crom R (2006). Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation  vol. 113, (23) 2744-2753. 10.1161/CIRCULATIONAHA.105.590018
Cheng C, Tempel D, Van Haperen R, Van Der Baan A, Grosveld F, Daemen MJAP, Krams R and De Crom R (2006). Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation  vol. 113, (23) 2744-2753. 10.1161/CIRCULATIONAHA.105.590018
Nette RW, Ie EHY, Vletter WB, Krams R, Weimar W and Zietse R (2006). Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients. Nephrology Dialysis Transplantation  vol. 21, (5) 1305-1311. 10.1093/ndt/gfk070

2005

Davies PF, Spaan JA and Krams R (2005). Shear stress biology of the endothelium. Annals of Biomedical Engineering  vol. 33, (12 SPEC. ISS.) 1714-1718. 10.1007/s10439-005-8774-0
Cheng C, Van Haperen R, De Waard M, Van Damme LCA, Tempel D, Hanemaaijer L, Van Cappellen GWA, Bos J, Slager CJ, Duncker DJ, Van Der Steen AFW, De Crom R and Krams R (2005). Shear stress affects the intracellular distribution of eNOS: Direct demonstration by a novel in vivo technique. Blood  vol. 106, (12) 3691-3698. 10.1182/blood-2005-06-2326
Ie EHY, Krams R, Vletter WB, Nette RW, Weimar W and Zietse R (2005). Myocardial contractility does not determine the haemodynamic response during dialysis. Nephrology Dialysis Transplantation  vol. 20, (11) 2465-2471. 10.1093/ndt/gfi088
Krams R, Verheye S, Van Damme LCA, Tempel D, Gourabi BM, Boersma E, Kockx MM, Knaapen MWM, Strijder C, Van Langenhove G, Pasterkamp G, Van Der Steen AFW and Serruys PW (2005). In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity. European Heart Journal  vol. 26, (20) 2200-2205. 10.1093/eurheartj/ehi461
Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, Serruys PW, De Feyter PJ and Slager CJ (2005). Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries. Journal of Biomechanics  vol. 38, (7) 1551-1555. 10.1016/j.jbiomech.2004.06.022
Segers D, Cheng C, De Crom R, Kirschbaum SWM, Oostlander AE, Helderman F, Van Wamel A, Slager CJ, Serruys PW, Van Der Steen AFW and Krams R (2005). Monocyte adhesion in atherosclerosis: A biomechanical approach. Vascular Disease Prevention  vol. 2, (3) 227-235. 10.2174/1567270054368998
Schaar JA, De Korte CL, Mastik F, Van Damme LCA, Krams R, Serruys PW and Van Der Steen AFW (2005). Three-dimensional palpography of human coronary arteries: Ex vivo validation and in-patient evaluation. Herz  vol. 30, (2) 125-133. 10.1007/s00059-005-2642-4
Krams R, Bambi G, Guidi F, Helderman F, Van Der Steen AFW and Tortoli P (2005). Effect of vessel curvature on Doppler derived velocity profiles and fluid flow. Ultrasound in Medicine and Biology  vol. 31, (5) 663-671. 10.1016/j.ultrasmedbio.2005.01.011
Wentzel JJ, Krams R and Slager CJ (2005). Letter regarding article by Korshunov and Berk, Strain-dependent vascular remodeling: the 'Glagov phenomenon' is genetically determined. Circulation  vol. 111, (9) 10.1161/01.CIR.0000157072.64410.01

2004

Cheng C, De Crom R, Van Haperen R, Helderman F, Gourabi BM, Van Damme LCA, Kirschbaum SW, Slager CJ, Van Der Steen AFW and Krams R (2004). The role of shear stress in atherosclerosis: Action through gene expression and inflammation? Cell Biochemistry and Biophysics  vol. 41, (2) 279-294. 10.1385/CBB:41:2:279
Krams R, Ten Cate FJ, Carlier SG, Van Der Steen AFW and Serruys PW (2004). Diastolic coronary vascular reserve: A new index to detect changes in the coronary microcirculation in hypertrophic cardiomyopathy. Journal of The American College of Cardiology  vol. 43, (4) 670-677. 10.1016/j.jacc.2003.09.046
Verheye S, De Meyer GRY, Krams R, Kockx MM, Van Damme LCA, Gourabi BM, Knaapen MWM, Van Langenhove G and Serruys PW (2004). Intravascular thermography: Immediate functional and morphological vascular findings. European Heart Journal  vol. 25, (2) 158-165. 10.1016/j.ehj.2003.10.023

2003

Van Haperen R, Cheng C, Mees BME, Van Deel E, De Waard M, Van Damme LCA, Van Gent T, Van Aken T, Krams R, Duncker DJ and De Crom R (2003). Functional expression of endothelial nitric oxide synthase fused to green fluorescent protein in transgenic mice. American Journal of Pathology  vol. 163, (4) 1677-1686. 10.1016/S0002-9440(10)63524-9
Diamantopoulos L, Liu X, De Scheerder I, Krams R, Li S, Van Cleemput J, Desmet W and Serruys PW (2003). The effect of reduced blood-flow on the coronary wall temperature: Are significant lesions suitable for intravascular thermography? European Heart Journal  vol. 24, (19) 1788-1795. 10.1016/S0195-668X(03)00440-8
de Feyter PJ, Serruys PW, Nieman K, Mollet N, Cademartiri F, van Geuns RJ, Slager C, van der Steen AFW, Krams R, Schaar JA, Wielopolski P, Pattynama PMT, Arampatzis A, van der Lugt A, Regar E, Ligthart J and Smits P (2003). Imaging of coronary atherosclerosis and identification of the vulnerable plaque. Neth Heart J  vol. 11, (9) 347-358.
Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, De Feyter PJ and Slager CJ (2003). Extension of increased atherosclerotic wall thickness into high shear stress regions is associated with loss of compensatory remodeling. Circulation  vol. 108, (1) 17-23. 10.1161/01.CIR.0000078637.21322.D3
Carlier SG, Van Damme LCA, Blommerde CP, Wentzel JJ, Van Langehove G, Verheye S, Kockx MM, Knaapen MWM, Cheng C, Gijsen F, Duncker DJ, Stergiopulos N, Slager CJ, Serruys PW and Krams R (2003). Augmentation of wall shear stress inhibits neointimal hyperplasia after stent implantation: Inhibition through reduction of inflammation? Circulation  vol. 107, (21) 2741-2746. 10.1161/01.CIR.0000066914.95878.6D
Wentzel JJ, Gijsen FJH, Stergiopulos N, Serruys PW, Slager CJ and Krams R (2003). Shear stress, vascular remodeling and neointimal formation. Journal of Biomechanics  vol. 36, (5) 681-688. 10.1016/S0021-9290(02)00446-3
Krams R, Segers D, Gourabi BM, Maat W, Cheng C, Van Pelt C, Van Damme LCA, De Feyter P, Van Der Steen T, De Korte CL and Serruys PW (2003). Inflammation and atherosclerosis: Mechanisms underlying vulnerable plaque. Journal of Interventional Cardiology  vol. 16, (2) 107-113. 10.1046/j.1540-8183.2003.08021.x

2002

Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ (2002). Focal in-stent restenosis near step-up - Roles of low and oscillating shear stress? Circulation  vol. 105, (23) E185-E187. 10.1161/01.CIR.0000018282.32332.13
Trines SAIP, Smits CAG, Van der Moer J, Slager CJ, Verdouw PD and Krams R (2002). Calcium sensitizer EMD 57033, but not the β1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium. Journal of Cardiovascular Pharmacology  vol. 39, (1) 61-72. 10.1097/00005344-200201000-00008
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ (2002). Images in cardiovascular medicine. Focal in-stent restenosis near step-up: roles of low and oscillating shear stress? Circulation  vol. 105, (23) 10.1161/01.cir.0000018282.32332.13
Thury A, Van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Sianos G, Wentzel JJ, Krams R, Slager CJ, Piek JJ and Serruys PW (2002). High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization. American Heart Journal  vol. 144, (1) 136-143. 10.1067/mhj.2002.123110

2001

Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P and Westerhof N (2001). Decrease in coronary vascular volume in systole augments cardiac contraction. American Journal of Physiology - Heart and Circulatory Physiology  vol. 281, (2 50-2)
Willemsen MJ, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P and Westerhof N (2001). Decrease in coronary vascular volume in systole augments cardiac contraction. Am J Physiol Heart Circ Physiol  vol. 281, (2) H731-H737. 10.1152/ajpheart.2001.281.2.H731
Wentzel JJ, Kloet J, Andhyiswara I, Oomen JAF, Schuurbiers JCH, De Smet BJGL, Post MJ, De Kleijn D, Pasterkamp G, Borst C, Slager CJ and Krams R (2001). Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: Effect of matrix metalloproteinase inhibition. Circulation  vol. 104, (1) 91-96. 10.1161/01.CIR.104.1.91
Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD and Krams R (2001). Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency. Cardiovascular Research  vol. 51, (1) 122-130. 10.1016/S0008-6363(01)00277-2
Wentzel JJ, Krams R, Schuurbiers JCH, Oomen JA, Kloet J, Van Der Giessen WJ, Serruys PW and Slager CJ (2001). Relationship between neointimal thickness and shear stress after wallstent implantation in human coronary arteries. Circulation  vol. 103, (13) 1740-1745. 10.1161/01.CIR.103.13.1740
Thury A, Wentzel JJ, Schuurbiers JC, Ligthart JM, Krams R, de Feyter PJ, Serruys PW and Slager CJ (2001). Prominent role of tensile stress in propagation of a dissection after coronary stenting: computational fluid dynamic analysis on true 3d-reconstructed segment. Circulation  vol. 104, (11) 10.1161/hc3601.095216

2000

Trines SAIP, Slager CJ, Van Der Moer J, Verdouw PD and Krams R (2000). Efficiency of energy transfer, but not external work, is maximized in stunned myocardium. American Journal of Physiology - Heart and Circulatory Physiology  vol. 279, (3 48-3)
De Zeeuw S, Trines SAIP, Krams R, Duncker DJ and Verdouw PD (2000). In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca2+ in stunned myocardium. European Journal of Pharmacology  vol. 403, (1-2) 99-109. 10.1016/S0014-2999(00)00513-6
Trines SA, Slager CJ, van der Moer J, Verdouw PD and Krams R (2000). Efficiency of energy transfer, but not external work, is maximized in stunned myocardium. Am J Physiol Heart Circ Physiol  vol. 279, (3) H1264-H1273. 10.1152/ajpheart.2000.279.3.H1264
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Kloet J, Krams R, Von Birgelen C, Van Der Giessen WJ, Serruys PW and De Feyter PJ (2000). True 3-dimensional reconstruction of coronary arteries in patients by fusion of angiography and IVUS (ANGUS) and its quantitative validation. Circulation  vol. 102, (5) 511-516. 10.1161/01.CIR.102.5.511
Bom N, De Korte CL, Wentzel JJ, Krams R, Carlier SG, Van Der Steen AWF, Slager CJ and Roelandt JRTC (2000). Quantification of plaque volume, shear stress on the endothelium, and mechanical properties of the arterial wall with intravascular ultrasound imaging. Zeitschrift Fur Kardiologie  vol. 89, (SUPPL. 2) 10.1007/s003920070108
De Zeeuw S, Trines SAIP, Krams R, Verdouw PD and Duncker DJ (2000). Cardiovascular profile of the calcium sensitizer EMD 57033 in open-chest anaesthetized pigs with regionally stunned myocardium. British Journal of Pharmacology  vol. 129, (7) 1413-1422. 10.1038/sj.bjp.0703231
Van Langenhove G, Wentzel JJ, Krams R, Slager CJ, Hamburger JN and Serruys PW (2000). Helical velocity patterns in a human coronary artery: a three-dimensional computational fluid dynamic reconstruction showing the relation with local wall thickness. Circulation  vol. 102, (3) 10.1161/01.cir.102.3.e22
Wentzel JJ, Whelan D, Van Der Giessen WJ, Van Beusekom HMM, Andhyiswara I, Serruys PW, Slager CJ and Krams R (2000). Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution. Journal of Biomechanics  vol. 33, (10) 1287-1295. 10.1016/S0021-9290(00)00066-X

1999

Soei LK, De Zeeuw S, Krams R, Duncker DJ and Verdouw PD (1999). Ca2+ sensitization and diastolic function of normal and stunned porcine myocardium. European Journal of Pharmacology  vol. 386, (1) 55-67. 10.1016/S0014-2999(99)00684-6
Krams R, Wentzel JJ, Cespedes I, Vinke R, Carlier S, Van Der Steen AFW, Lancee CT and Slager CJ (1999). Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system. Ultrasound in Medicine and Biology  vol. 25, (5) 803-810. 10.1016/S0301-5629(99)00018-6

1998

Osterop AP, Kofflard MJ, Sandkuijl LA, ten Cate FJ, Krams R, Schalekamp MA and Danser AH (1998). AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy. Hypertension  vol. 32, (5) 825-830. 10.1161/01.hyp.32.5.825
Krams R, Kofflard MJM, Duncker DJ, Von Birgelen C, Carlier S, Kliffen M, Ten Cate FJ and Serruys PW (1998). Decreased coronary flow reserve in hypertrophic cardiomyopathy is related to remodeling of the coronary microcirculation. Circulation  vol. 97, (3) 230-233. 10.1161/01.CIR.97.3.230
Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B, Borst C, Slager CJ and Serruys PW (1998). Shear stress in atherosclerosis, and vascular remodelling. Seminars in Interventional Cardiology : Siic  vol. 3, (1) 39-44.
Osterop APRM, Kofflard MJM, Sandkuijl LA, Ten Cate FJ, Krams R, Schalekamp MADH and Danser AHJ (1998). AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy. Hypertension  vol. 32, (5) 825-830. 10.1161/01.HYP.32.5.825

1997

Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R (1997). Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium. American Journal of Physiology - Heart and Circulatory Physiology  vol. 273, (5 42-5)
Dongsheng FA, Kie Soei LO, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams ROB (1997). Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium. American Journal of Physiology - Heart and Circulatory Physiology  vol. 42, (5)
Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R (1997). Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium. Am J Physiol  vol. 273, (5) H2146-H2154. 10.1152/ajpheart.1997.273.5.H2146
Fan DS, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R (1997). Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium. American Journal of Physiology-Heart and Circulatory Physiology  vol. 273, (5) H2146-H2154.
Van Blankenstein JH, Slager CJ, Soei LK, Boersma H, Stijnen T, Schuurbiers JCH, Krams R, Lachmann B and Verdouw PD (1997). Cardiac depression after experimental air embolism in pigs: Role of addition of a surface-active agent. Cardiovascular Research  vol. 34, (3) 473-482. 10.1016/S0008-6363(97)00063-1
Van Der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Verdouw PD, Roelandt JRTC and Bom N (1997). Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium. Ultrasound in Medicine and Biology  vol. 23, (3) 405-414. 10.1016/S0301-5629(96)00227-X
Krams R, Wentzel JJ, Oomen JAF, Vinke R, Schuurbiers JCH, De Feyter PJ, Serruys PW and Slager CJ (1997). Evaluation of endothelial shear stress and 3D geometry as factors determining the development of atherosclerosis and remodeling in human coronary arteries in vivo: Combining 3D reconstruction from angiography and IVUS (ANGUS) with computational fluid dynamics. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 17, (10) 2061-2065. 10.1161/01.ATV.17.10.2061
Slager CJ, Wentzel JJ, Oomen JA, Schuurbiers JC, Krams R, von Birgelen C, Tjon A, Serruys PW and de Feyter PJ (1997). True reconstruction of vessel geometry from combined X-ray angiographic and intracoronary ultrasound data. Seminars in Interventional Cardiology : Siic  vol. 2, (1) 43-47.

1996

Bezstarosti K, Soei LK, Krams R, Ten Cate FJ, Verdouw PD and Lamers JMJ (1996). The effect of a thiadiazinone derived Ca2+ sensitizer on the responsiveness of Mg2+-ATPase to Ca2+ in myofibrils isolated from stunned and nonstunned porcine and human myocardium. Biochemical Pharmacology  vol. 51, (9) 1211-1220. 10.1016/0006-2952(96)00083-4
Rijsterborgh H, Van Der Steen AFW, Krams R, Mastik F, Lancée CT, Verdouw PD, Roelandt JRTC and Bom N (1996). The relationship between myocardial integrated backscatter, perfusion pressure and wall thickness during isovolumic contraction: An isolated pig heart study. Ultrasound in Medicine and Biology  vol. 22, (1) 43-52. 10.1016/0301-5629(95)02030-6

1995

Fan D, Soei LK, Sassen LMA, Krams R and Verdouw PD (1995). Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency. Cardiovascular Research  vol. 29, (3) 428-437. 10.1016/0008-6363(96)88602-0
Di Mario C, Gil R, Krams R, De Feyter PJ and Serruys W (1995). New invasive techniques of assessment of the physiological significance of coronary stenoses in humans. European Heart Journal  vol. 16, (SUPPL. I) 104-114. 10.1093/eurheartj/16.suppl_i.104
Wilson RA, di Mario C, Krams R, Soei LK, Wenguang L, Laird AC, The SHK, Gussenhoven E, Verdouw P and Roelandt JRTC (1995). In Vivo Measurement of Regional Large Artery Compliance by Intravascular Ultrasound Under Pentobarbital Anesthesia. Angiology  vol. 46, (6) 481-488. 10.1177/000331979504600604

1994

Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ and Verdouw PD (1994). Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship. Am J Physiol  vol. 267, (4 Pt 2) H1557-H1564. 10.1152/ajpheart.1994.267.4.H1557
KRAMS R, JANSSEN M, VANDERLEE C, VANMEEGEN J, DEJONG JW, SLAGER CJ and VERDOUW PD (1994). LOSS OF ELASTIC RECOIL IN POSTISCHEMIC MYOCARDIUM INDUCES RIGHTWARD SHIFT OF THE SYSTOLIC PRESSURE-VOLUME RELATIONSHIP. American Journal of Physiology-Heart and Circulatory Physiology  vol. 267, (4) H1557-H1564.
Fan D, Soei LK, Sassen LM, Krams R and Verdouw PD (1994). Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency. Cardiovascular Research  vol. 28, (9) 428-437. 10.1016/S0008-6363(96)88602-0
Loe Kie Soei , Sassen LMA, Dong Sheng Fan , Van Veen T, Krams R and Verdouw PD (1994). Myofibrillar Ca2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium. Circulation  vol. 90, (2) 959-969. 10.1161/01.cir.90.2.959
Fan D, Kie Soei L, Sassen LMA, Krams R, Hendrik E and Verdouw PD (1994). On the Reversal of Myocardial Stunning: A Role for Ca2+-Sensitizers. Ann N Y Acad Sci  vol. 723, (1) 364-367. 10.1111/j.1749-6632.1994.tb36748.x
FAN D, KIE SOEI L, SASSEN LMA, KRAMS R, HENDRIK E and VERDOUW PD (1994). On the Reversal of Myocardial Stunning: A Role for Ca2+‐Sensitizers. Annals of The New York Academy of Sciences  vol. 723, (1) 364-367. 10.1111/j.1749-6632.1994.tb36748.x
Di Mario C, Krams R, Gil R and Serruys PW (1994). Slope of the instantaneous hyperemic diastolic coronary flow velocity- pressure relation: A new index for assessment of the physiological significance of coronary stenosis in humans. Circulation  vol. 90, (3) 1215-1224. 10.1161/01.CIR.90.3.1215
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ and Verdouw PD (1994). Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship. American Journal of Physiology - Heart and Circulatory Physiology  vol. 267, (4 36-4) 10.1152/ajpheart.1994.267.4.h1557
Fan D, Sassen LMA, Trines SAIP, Soei LK, Krams R and Verdouw PD (1994). Increasing the Ca++ sensitivity reverses the increased afterload dependency of external work and the efficiency of energy conversion of stunned myocardium. Applied Cardiopulmonary Pathophysiology  vol. 5, (2) 63-72.

1993

Krams R, Soei LK, McFalls EO, Winkler Prins EA, Sassen LM and Verdouw PD (1993). End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation. Am J Physiol  vol. 265, (6 Pt 2) H2099-H2109. 10.1152/ajpheart.1993.265.6.H2099
KRAMS R, SOEI LK, MCFALLS EO, PRINS EAW, SASSEN LMA and VERDOUW PD (1993). END-SYSTOLIC PRESSURE LENGTH RELATIONS OF STUNNED RIGHT-AND-LEFT-VENTRICLES AFTER INOTROPIC STIMULATION. American Journal of Physiology  vol. 265, (6) H2099-H2109.
Krams R, Loe Kie Soei , McFalls EO, Prins EAW, Sassen LMA and Verdouw PD (1993). End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation. American Journal of Physiology - Heart and Circulatory Physiology  vol. 265, (6 34-6)
Koning MMG, Krams R, Xiao CS, van Meegen JR, Bezstarosti K, Lamers JMJ and Verdouw PD (1993). Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia. Cardiovascular Drugs and Therapy  vol. 7, (5) 801-807. 10.1007/BF00878934
(1993). Altered coronary flow reserve in the hypertrophied heart: Implications for therapy. Journal of Human Hypertension  vol. 7, (SUPPL. 1)
Duncker DJ, Sassen LMA, Bartels GL, Van Meegen JR, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD (1993). L-propionylcarnitine does not affect myocardial metabolic or functional response to chronotropic and inotropic stimulation after repetitive ischemia in anesthetized pigs. Journal of Cardiovascular Pharmacology  vol. 22, (3) 488-498. 10.1097/00005344-199309000-00022
Krams R, Duncker DJ, McFalls EO, Hogendoorn A and Verdouw PD (1993). Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium. Cardiovascular Research  vol. 27, (5) 740-747.

1992

McFalls EO, Duncker DJ, Krams R, Sassen LM, Hoogendoorn A and Verdouw PD (1992). Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium. Am J Physiol  vol. 263, (6 Pt 2) H1724-H1731. 10.1152/ajpheart.1992.263.6.H1724
McFalls EO, Duncker DJ, Krams R, Sassen LMA, Hoogendoorn A and Verdouw PD (1992). Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium. American Journal of Physiology - Heart and Circulatory Physiology  vol. 263, (6 32-6)
MCFALLS EO, DUNCKER DJ, KRAMS R, SASSEN LMA, HOOGENDOORN A and VERDOUW PD (1992). RECRUITMENT OF MYOCARDIAL WORK AND METABOLISM IN REGIONALLY STUNNED PORCINE MYOCARDIUM. American Journal of Physiology  vol. 263, (6) H1724-H1731.
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD (1992). L-propionylcarnitine and myocardial performance in stunned porcine myocardium. Molecular and Cellular Biochemistry  vol. 116, (1-2) 147-153. 10.1007/BF01270582
Duncker DJ, McFalls EO, Krams R and Verdouw PD (1992). Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium. Am J Physiol  vol. 262, (6 Pt 2) H1744-H1751. 10.1152/ajpheart.1992.262.6.H1744
DUNCKER DJ, MCFALLS EO, KRAMS R and VERDOUW PD (1992). PRESSURE-MAXIMAL CORONARY FLOW RELATIONSHIP IN REGIONALLY STUNNED PORCINE MYOCARDIUM. American Journal of Physiology  vol. 262, (6) H1744-H1751.
Duncker DJ, McFalls EO, Krams R and Verdouw PD (1992). Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium. American Journal of Physiology - Heart and Circulatory Physiology  vol. 262, (6 31-6)

1991

McFalls EO, Duncker DJ, Krams R, Ward H, Gornick C and Verdouw PD (1991). Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine. Cardiovascular Research  vol. 25, (8) 659-665. 10.1093/cvr/25.8.659
Krams R, McFalls E, van der Giessen WJ, Serruys PW, Verdoun PD and Roelandt J (1991). Does intravenous milrinone have a direct effect on diastolic function? Am Heart J  vol. 121, (6 Pt 2) 1951-1955. 10.1016/0002-8703(91)90831-2
Mcfalls EO, Duncker DJ, Krams R, Ward H, Gornick C and Verdouw PD (1991). Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine. Cardiovascular Research  vol. 25, (8) 659-665. 10.1093/cvr/25.8.659

1990

WESTERHOF N, SIPKEMA P and KRAMS R (1990). MYOCARDIAL MODULATION OF CORONARY CIRCULATION - REPLY. American Journal of Physiology  vol. 259, (6) H1936-H1937.
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R and Yin FC (1990). Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum. Am J Physiol  vol. 259, (6 Pt 2) H1869-H1880. 10.1152/ajpheart.1990.259.6.H1869
Westerhof N, Sipkema P and Krams R (1990). Myocardial modulation of coronary circulation Reply). American Journal of Physiology - Heart and Circulatory Physiology  vol. 259, (6 28-6)
RESAR J, LIVINGSTON JZ, HALPERIN HR, SIPKEMA P, KRAMS R and YIN FCP (1990). EFFECT OF WALL STRETCH ON CORONARY HEMODYNAMICS IN ISOLATED CANINE INTERVENTRICULAR SEPTUM. American Journal of Physiology  vol. 259, (6) H1869-H1880.
Krams R, Sipkema P and Westerhof N (1990). Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure. Am J Physiol  vol. 258, (6 Pt 2) H1889-H1898. 10.1152/ajpheart.1990.258.6.H1889
KRAMS R, SIPKEMA P and WESTERHOF N (1990). CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE. American Journal of Physiology  vol. 258, (6) H1889-H1898.
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R and Yin FCP (1990). Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum. American Journal of Physiology - Heart and Circulatory Physiology  vol. 259, (6 28-6) 10.1152/ajpheart.1990.259.6.h1869
Krams R, Sipkema P and Westerhof N (1990). Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure. American Journal of Physiology - Heart and Circulatory Physiology  vol. 258, (6 27-6) 10.1152/ajpheart.1990.258.6.h1889

1989

Krams R, Sipkema P, Zegers J and Westerhof N (1989). Contractility is the main determinant of coronary systolic flow impediment. Am J Physiol  vol. 257, (6 Pt 2) H1936-H1944. 10.1152/ajpheart.1989.257.6.H1936
Krams R, Sipkema P, Zegers J and Westerhof N (1989). Contractility is the main determinant of coronary systolic flow impediment. American Journal of Physiology - Heart and Circulatory Physiology  vol. 257, (6)
Krams R, Sipkema P and Westerhof N (1989). Varying elastance concept may explain coronary systolic flow impediment. Am J Physiol  vol. 257, (5 Pt 2) H1471-H1479. 10.1152/ajpheart.1989.257.5.H1471
Krams R, van Haelst ACTA, Sipkema P and Westerhof N (1989). Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance? Basic Research in Cardiology  vol. 84, (2) 149-159. 10.1007/BF01907924
Krams R, Sipkema P and Westerhof N (1989). Varying elastance concept may explain coronary systolic flow impediment. American Journal of Physiology - Heart and Circulatory Physiology  vol. 257, (5)

1988

Van Dijk LC, Krams R, Sipkema P and Westerhof N (1988). Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion. Am J Physiol  vol. 255, (3 Pt 2) H476-H482. 10.1152/ajpheart.1988.255.3.H476
Van Dijk LC, Krams R, Sipkema P and Westerhof N (1988). Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion. American Journal of Physiology - Heart and Circulatory Physiology  vol. 255, (3)

1986

Westerhof N, Krams R and Canty JM (1986). Comments on 'pressure and tone dependence of coronary diastolic input impedance and capacitance'. American Journal of Physiology - Heart and Circulatory Physiology  vol. 250, (2)
WESTERHOF N and KRAMS R (1986). PRESSURE AND TONE DEPENDENCE OF CORONARY DIASTOLIC INPUT IMPEDANCE AND CAPACITANCE - COMMENT. American Journal of Physiology  vol. 250, (2) H330-H330.
Westerhof N and Krams R (1986). Comments on Pressure and tone dependence of coronary diastolic input impedance and capacitance. Am J Physiol  vol. 250, (2 Pt 2) H330-H331. 10.1152/ajpheart.1986.250.2.H330

1984

Borgdorff P, Braakman R, van Haelst AC, van Huis GA, de Jong JP, Krams R, Langewouters GJ, Sipkema P and Westerhof N (1984). Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog. Circulation Research  vol. 54, (3) 10.1161/01.RES.54.3.348

1982

BRAAKMAN R, VANDERHORN GJ, VONHUIS GA, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P and WESTERHOF N (1982). THE EFFECTS OF THE CORONARY CAPACITANCE ON THE INTERPRETATION OF DIASTOLIC PRESSURE-FLOW RELATIONSHIPS - COMMENTS. Circulation Research  vol. 51, (6) 822-822.