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Dr Thomas Iskratsch

Thomas IskratschPhD, Dipl.-Ing.

Senior Lecturer for Bioengineering /
(Responsible for Industrial Engagement and the PREMMIR Centre for Doctoral Training)

School of Engineering and Materials Science
Queen Mary University of London
+44 (0)20 7882 3674

Publications of specific relevance to Predictive in vitro Models



Ward M and Iskratsch T (2020). Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart. Biochimica Et Biophysica Acta - Molecular Cell Research  vol. 1867, (3) 10.1016/j.bbamcr.2019.01.017


Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Elsevier  Biomaterials  vol. 232, 10.1016/j.biomaterials.2019.119683
Xanthis I and Iskratsch T (2019). Lamin-A Mechano-Protects the Heart. Developmental Cell  10.1016/j.devcel.2019.05.041
Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T and Hodivala-Dilke K (2019). Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation. American Association For Cancer Research  Cancer Research  10.1158/0008-5472.CAN-18-3934
Sit B, Gutmann D and Iskratsch T (2019). Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing. Journal of Muscle Research and Cell Motility  vol. 40, (2) 197-209. 10.1007/s10974-019-09529-7


Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T and Lappalainen P (2018). Calponin-3 is critical for coordinated contractility of actin stress fibers. Nature Publishing Group  Scientific Reports  10.1038/s41598-018-35948-6
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell  vol. 44, (3) 326-336.e3. 10.1016/j.devcel.2017.12.024


Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN and Lu HH (2017). Polymer fiber-based models of connective tissue repair and healing. Biomaterials  vol. 112, 303-312. 10.1016/j.biomaterials.2016.10.013


Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML and Sheetz MP (2016). Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol  vol. 94, (10) 981-993. 10.1038/icb.2016.61
(2016). α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions. Mol Biol Cell  vol. 27, (22) 3471-3479. 10.1091/mbc.E16-02-0107


(2015). Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices. Nat Cell Biol  vol. 18, (1) 33-42. 10.1038/ncb3277
Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC and Iskratsch T (2015). Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells. Integr Biol (Camb)  vol. 7, (10) 1272-1284. 10.1039/c5ib00032g


Wolfenson H, Iskratsch T and Sheetz MP (2014). Early events in cell spreading as a model for quantitative analysis of biomechanical events. Biophysical Journal  vol. 107, (11) 2508-2514. 10.1016/j.bpj.2014.10.041
Iskratsch T, Wolfenson H and Sheetz MP (2014). Appreciating force and shape—the rise of mechanotransduction in cell biology. Nature Reviews. Molecular Cell Biology  vol. 15, (12) 825-833. 10.1038/nrm3903
Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG and Ehler E (2014). The formin FHOD1 in cardiomyocytes. Anat Rec (Hoboken)  vol. 297, (9) 1560-1570. 10.1002/ar.22984
Zhang X, Moore SW, Iskratsch T and Sheetz MP (2014). N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading. Journal of Cell Science  vol. 127, (7) 1394-1405. 10.1242/jcs.134692


Iskratsch T, Yu CH, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E and Sheetz M (2013). FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration. Developmental Cell  vol. 27, (5) 545-559. 10.1016/j.devcel.2013.11.003
Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I and Ehler E (2013). Two distinct phosphorylation events govern the function of muscle FHOD3. Cellular and Molecular Life Sciences  vol. 70, (5) 893-908. 10.1007/s00018-012-1154-7
Lynch CD, Lazar AM, Iskratsch T, Zhang X and Sheetz MP (2013). Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions. Molecular Biology of The Cell  vol. 24, (1) 21-30. 10.1091/mbc.E12-05-0377


Dwyer J, Iskratsch T and Ehler E (2012). Actin in striated muscle: Recent insights into assembly and maintenance. Biophysical Reviews  vol. 4, (1) 17-25. 10.1007/s12551-011-0062-7
Roca-Cusachs P, Iskratsch T and Sheetz MP (2012). Finding the weakest link-exploring integrin-mediated mechanical molecular pathways. Journal of Cell Science  vol. 125, (13) 3025-3038. 10.1242/jcs.095794


Iskratsch T and Ehler E (2011). Formin-g muscle cytoarchitecture. Bioarchitecture  vol. 1, (2) 66-68. 10.4161/bioa.1.2.15467


Iskratsch T, Lange S, Dwyer J, Kho AL, Dos Remedios C and Ehler E (2010). Formin follows function: A muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. Journal of Cell Biology  vol. 191, (6) 1159-1172. 10.1083/jcb.201005060


Herbst R, Iskratsch T, Unger E and Bittner RE (2009). Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice. Neuromuscular Disorders  vol. 19, (5) 366-378. 10.1016/j.nmd.2009.02.011
Gutternigg M, Rendi D, Voglauer R, Iskratsch T and Wilson IBH (2009). Mammalian cells contain a second nucleocytoplasmic Hexosaminidase. Biochemical Journal  vol. 419, (1) 83-90. 10.1042/BJ20081630
Iskratsch T, Braun A, Paschinger K and Wilson IBH (2009). Specificity analysis of lectins and antibodies using remodeled glycoproteins. Analytical Biochemistry  vol. 386, (2) 133-146. 10.1016/j.ab.2008.12.005


Grants of specific relevance to Predictive in vitro Models
Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopillars
Iskratsch T
£490,544 Biotechnology and Biological Sciences Research Council (01-02-2019 - 31-01-2022)