Publications
The following journal papers published by the members of the CPM, specifically relate to the development and/or use of predictive in vitro models.
- Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T, Krause S
Biosensors and Bioelectronics, Elsevier vol. 223
21-12-2022 - Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance
Croft CL, Paterno G, Vause AR, Rowe LA, Ryu DH, Goodwin MS, Moran CA, Cruz PE et al.
Npj Parkinson's Disease, Springer Nature vol. 8 (1)
19-12-2022 - Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
Khalil B, Chhangani D, Wren MC, Smith CL, Lee JH, Li X, Puttinger C, Tsai C-W et al.
Molecular Neurodegeneration, Springer Nature vol. 17 (1)
08-12-2022 - Current Understanding of the Role of Senescent Melanocytes in Skin Ageing
Hughes BK, Bishop CL
Biomedicines, Mdpi vol. 10 (12)
02-12-2022 - 181 Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions
Smith CJ, Williams JL, Hall C, Caley MP, O’Toole EA, Prasad R, Metherell LA
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022 - 200 Optimised 3D skin models incorporating microbiome and host immune responses
McPolin-Hall E, Stephens A, Pardieu C, Allaker R, Philpott M, Pople J, Hannen R
Journal of Investigative Dermatology, Elsevier vol. 142 (12)
01-12-2022 - Obituary — Werner W. Franke
Unsicker K, Jockusch BM, Kelsell DP
Cell and Tissue Research, Springer Nature vol. 390 (3), 315-316.
29-11-2022 - Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape
Boot J, Rosser G, Kancheva D, Vinel C, Lim YM, Pomella N, Zhang X, Guglielmi L et al.
Elife, Elife vol. 11
22-11-2022 - Organ-on-a-Chip Technologies Network special issue editorial
Biddle A
In Vitro Models, Springer Nature vol. 1 (6), 397-398.
17-11-2022 - Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia
Dembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al.
Blood, American Society of Hematology vol. 140 (Supplement 1), 3058-3060.
15-11-2022 - Photoelectrochemical Detection of Calcium Ions Based on Hematite Nanorod Sensors
Zhou B, Jiang Y, Guo Q, Das A, Sobrido ABJ, Hing KA, Zayats AV, Krause S
Acs Applied Nano Materials, American Chemical Society (Acs) vol. 5 (11), 17087-17094.
10-11-2022 - CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al.
Neuromuscular Disorders
01-11-2022 - Identification of a novel specific small-molecule melanocortin-2-receptor antagonist
Forfar R, Hussain M, Khurana P, Cook J, Lewis S, Popat D, Jackson D, McIver E
Endocrine Connections, Bioscientifica vol. 11 (12)
31-10-2022 - The RNA repair proteins RtcAB regulate transcription activator RtcR via its CRISPR-associated Rossmann fold domain.
Kotta-Loizou I, Giuliano MG, Jovanovic M, Schaefer J, Ye F, Zhang N, Liu X, Zhang X
Iscience, Cell Press, 105425-105425.
20-10-2022 - The Architecture of Oligonucleotide‐Polycationic Brush Complexes – A Neutron Reflectometry Study
Gautrot JE, Chang L, Alexis C, Gutfreund P, Zarbakhsh A
Advanced Materials Interfaces, Wiley vol. 9 (33)
13-10-2022 - Hybrid cellular automaton representation of the influence of mechanical stimulation on the development of bone metastases
Villette C, Geris L
10-10-2022 - C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity
Perez-Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT, Hobbs AJ
Frontiers in Molecular Neuroscience, Frontiers vol. 15
04-10-2022 - Regulation of cardiomyocyte adhesion and mechanosignalling through distinct nanoscale behaviour of integrin ligands mimicking healthy or fibrotic extracellular matrix
Hawkes W, Marhuenda E, Reynolds P, O'Neill C, Pandey P, Wilson DGS, Freeley M, Huang D et al.
Philosophical Transactions of The Royal Society B Biological Sciences, The Royal Society vol. 377 (1864)
03-10-2022 - High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices
Thau-Zuchman O, Pallier PN, Savelkoul PJM, Kuipers AAM
Frontiers in Neuroscience, Frontiers vol. 16
29-09-2022 - ESDR200 - Optimised 3D skin models incorporating microbiome and host immune responses
McPolin-Hall E, Stephens A, Pardieu C, Allaker R, Philpott M, Pople J, Hannen R
, Morressier
26-09-2022 - Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF, Jones JL
Npj Breast Cancer, Springer Nature vol. 8 (1)
20-09-2022 - The tumour microenvironment of clear cell ovarian cancer
Devlin M-J, Miller R, Laforets F, Kotantaki P, Garsed DW, Kristeleit R, Bowtell DD, McDermott J et al.
Cancer Immunology Research, American Association For Cancer Research (Aacr) vol. 10 (11), 1326-1339.
12-09-2022 - Molecular Origins of Transcriptional Heterogeneity in Diazotrophic Klebsiella oxytoca
Bashir T, Brackston RD, Waite C, Kotta-Loizou I, Engl C, Schumacher J
Msystems, American Society For Microbiology vol. 7 (5), e00596-e00522.
08-09-2022 - JAG1-NOTCH4 mechanosensing drives atherosclerosis
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 8 (35)
31-08-2022 - Single molecule DNA origami nanoarrays with controlled protein orientation
Cervantes-Salguero K, Freeley M, Gwyther REA, Jones DD, Chávez JL, Palma M
Biophysics Reviews, Aip Publishing vol. 3 (3)
18-08-2022 - Adhesive peptide and polymer density modulate 3D cell traction forces within synthetic hydrogels
Colasurdo M, Nieves EB, Fernández-Yagüe MA
Biomaterials, Elsevier vol. 288
11-08-2022 - Bioengineering Human Cartilage-Bone Tissues for Modeling of Osteoarthritis.
Wu JY, Vunjak-Novakovic G
Stem Cells Dev vol. 31 (15-16), 399-405.
01-08-2022 - Acoustically accelerated neural differentiation of human embryonic stem cells
Sun C, Dong Y, Wei J, Cai M, Liang D, Fu Y, Zhou Y, Sui Y et al.
Acta Biomaterialia, Elsevier vol. 151, 333-345.
29-07-2022 - Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model
Jones CFE, Di Cio S, Connelly JT
Frontiers in Bioengineering and Biotechnology, Frontiers vol. 10
19-07-2022 - Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth
Perdrix Rosell A, Maiques O, Martin JAJ, Ombrato L, Malanchi I
Cancer Letters, Elsevier vol. 544
06-07-2022 - FRI198 Investigating the function of Endothelial-To-Mesenchymal transition during liver fibrogenesis using a Liver-On-A-Chip platform
Whiteford J, Arokiasamy S, Thompson C, Alazawi W
Journal of Hepatology, Elsevier vol. 77
01-07-2022 - Highlight: microfluidic devices for cancer metastasis studies
Scemama A, Biddle A
In Vitro Models, Springer Nature vol. 1 (6), 399-403.
27-06-2022 - Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models
Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV
Biomolecules, Mdpi vol. 12 (6)
16-06-2022 - Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network
Lin T, Wang Z, Lu RX, Wang W, Sui Y
Advances in Applied Mathematics and Mechanics, Global Science Press vol. 14 (1), 79-100.
01-06-2022 - Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A et al.
Nature Medicine, Springer Nature vol. 28 (6), 1256-1268.
19-05-2022 - Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence
Wallis R, Milligan D, Hughes B, Mizen H, López-Domínguez JA, Eduputa U, Tyler EJ, Serrano M et al.
Aging, Impact Journals vol. 14 (10), 4220-4246.
16-05-2022 - Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression
Parry CM, Chan LF, Carr DF
Pediatric Research, Springer Nature vol. 93 (1), 97-101.
14-05-2022 - DLK1 expressing cells mark a population of progenitor cells in the adrenal cortex and contribute to the zonation of the adrenal gland
Mariniello K, Guasti L
Endocrine Abstracts, Bioscientifica
07-05-2022 - Nutrient-Response Pathways in Healthspan and Lifespan Regulation
Dabrowska A, Kumar J, Rallis C
Cells, Mdpi vol. 11 (9)
06-05-2022 - Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions
Ghorbani S, Shahrokhtash A
Small Methods, Wiley vol. 6 (6)
22-04-2022 - Organ-on-a-chip: current gaps and future directions
Candarlioglu PL, Dal Negro G, Hughes D, Balkwill F, Harris K, Screen H, Morgan H, David R et al.
Biochemical Society Transactions, Portland Press vol. 50 (2), 665-673.
19-04-2022 - Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 8 (15)
15-04-2022 - Impact of the multiscale viscoelasticity of quasi-2D self-assembled protein networks on stem cell expansion at liquid interfaces
Kong D, Peng L, Bosch-Fortea M, Chrysanthou A, Alexis CVJ-M, Matellan C, Zarbakhsh A, Mastroianni G et al.
Biomaterials, Elsevier vol. 284
06-04-2022 - A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels
Fernandez-Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Stapleton A, Palma M
Advanced Materials, Wiley vol. 34 (14)
01-04-2022 - Improving the accuracy and robustness of carotid-femoral pulse wave velocity measurement using a simplified tube-load model
Xu L, Zhou S, Wang L, Hao L, Qi L, Yao Y, Han H
Scientific Reports, Springer Nature vol. 12 (1)
25-03-2022 - Assessing the Role of Carbonyl Adducts, Particularly Malondialdehyde Adducts, in the Development of Dermis Yellowing Occurring during Skin Photoaging
Zucchi H, Pageon H, Asselineau D, Ghibaudo M, Sequeira I
Life, Mdpi vol. 12 (3)
10-03-2022 - Fabrication of Human Skin Equivalents Using Decellularized Extracellular Matrix
Sarmin AM
Current Protocols, Wiley vol. 2 (3)
01-03-2022 - Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets
Fernandez-Yague MA, Hymel LA, Olingy CE, McClain C, Ogle ME, García JR, Minshew D, Lim HS et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 8 (8)
25-02-2022 - Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma
Badodi S, Pomella N, Lim YM, Brandner S, Morrison G, Pollard SM, Zhang X, Zabet NR et al.
Neuro-Oncology, Oxford University Press (Oup) vol. 24 (8), 1273-1285.
25-02-2022 - Highly Stretchable Conductive Covalent Coacervate Gels for Electronic Skin
Nguyen NT, Jennings J, Milani AH, Martino CDS, Nguyen LTB, Wu S, Saunders JM, Armes SP
Biomacromolecules, American Chemical Society (Acs) vol. 23 (3), 1423-1432.
21-02-2022 - CRISPR-mediated correction of skeletal muscle Ca2+handling in a novel DMD patient-derived pluripotent stem cell model
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J et al.
18-02-2022 - Extracellular Adhesive Cues Physically Define Nucleolar Structure and Function
Pundel OJ, Blowes LM
Advanced Science, Wiley vol. 9 (10)
05-02-2022 - OP37 Bacterial suppression of intestinal fungi via activation of human gut Vδ2+ T-cells
Mathew L, Savage M, Pardieu C, O’Brien M, Sze SK, Eberl M, Stagg A, Gasparetto M et al.
Journal of Crohn's and Colitis, Oxford University Press (Oup) vol. 16 (Supplement_1), i043-i044.
21-01-2022 - Methods of producing three dimensional electrospun scaffolds for bone tissue engineering: A review
Kareem MM, Tanner K
Proceedings of The Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, Sage Publications vol. 236 (4), 483-495.
20-01-2022 - Building in vitro 3D human multicellular models of high-grade serous ovarian cancer
Malacrida B, Balkwill FR
Star Protocols, Elsevier vol. 3 (1)
11-01-2022 - Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM, Lee DA
In Vitro Models, Springer Nature vol. 1 (6), 405-412.
01-01-2022 - Semi-Supervised Analysis of Myeloid and T Cell Behaviour in ex vivo Ovarian Tumour Slices Reveals Changes in Cell Motility After Treatments
Laforêts F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E, Balkwill F
01-01-2022 - TGFß-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer
Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S et al.
01-01-2022 - Hematite Nanorods as a Platform for Photoelectrochemical Imaging and Sensing
Krause S, Zhou B, Jiang Y, Guo Q, Das A, Sobrido AJ, Hing KA, Zayats AV
In Ssrn Electronic Journal
01-01-2022 - Novel application of live imaging to determine the functional cell biology of endothelial-to-mesenchymal transition (EndMT) within a liver-on-a-chip platform
Whiteford J, Arokiasamy S, Thompson CL, Dufton NP
In Vitro Models, Springer Nature vol. 1 (6), 413-421.
01-01-2022 - Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al.
Cell Reports, Elsevier vol. 38 (4)
01-01-2022 - Novel therapeutic models for adrenal disorders
Guasti L
01-01-2022