Prof Li Chan

Li Chan

Professor of Molecular Endocrinology and Metabolism/Paediatric Endocrinologist

Centre for Endocrinology
Queen Mary University of London
ORCID X

Research

Obesity, HPA, Melanocortin receptors, Accessory proteins, Appetite, Stress

Neuronal Models

Interests

I am Professor of Molecular Endocrinology and Metabolism/Honorary Consultant Paediatric Endocrinology at QMUL and Barts Health. My research is in the area of adrenal and metabolic dysfunction and as such I work on in-vitro and in-vivo models for these.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Friedman HR, Gaston L, Chan L and Majzoub JA (2024). 6569 An Increase, Rather Than Absolute Amount, Of Corticotropin-Releasing Hormone (Crh) Drives Mouse Anxiety-Like Behavior. The Endocrine Society  Journal of the Endocrine Society  vol. 8, (Supplement_1)  
Smith CJ, Abdullah MA, Hassan SS, Fauzi LS, Qamar Y, Hall CL, Maitra S, Maharaj AV, Ramirez LMM, Read JE, Chan L, Metherell L and Musa SA (2024). 8482 Genetic Aetiology Of Primary Adrenal Insufficiency In Sudan. The Endocrine Society  Journal of the Endocrine Society  vol. 8, (Supplement_1)  
Elhassan YS, Appenzeller S, Landwehr L-S, Lippert J, Popat D, Gilligan LC, Abdi L, Goh E, Diaz-Cano S, Kircher S, Gramlich S, Sutcliffe RP, Thangaratinam S, Chan LF, Fassnacht M, Arlt W and Ronchi CL (2024). Primary unilateral macronodular adrenal hyperplasia with concomitant glucocorticoid and androgen excess and KDM1A inactivation. Oxford University Press (OUP)  European Journal of Endocrinology  vol. 191, (3) 334-344.  
Ramakrishnan A, Popat D, Purushothaman P, Chan LF and Gevers EF (2024). A Novel Maternally Inherited GNAS Variant in a Family With Hyperphagia and Obesity: 3 Cases. The Endocrine Society  JCEM Case Reports  vol. 2, (8)  
Elhassan Y, Appenzeller S, Landwehr L-S, Lippert J, Popat D, C. GL, Abdi L, Goh E, Diaz-Cano S, Kircher S, Gramlich S, Sutcliffe R, Thangaratinam S, Chan L, Fassnacht M, Arlt W and L RC (2024). Primary unilateral macronodular adrenal hyperplasia with concomitant glucocorticoid and androgen excess and KDM1A inactivation. Bioscientifica  Endocrine Abstracts   

2023

Purushothaman P, Popat D, Ramakrishnan A, Chan L and Gevers E (2023). A novel maternally inherited GNAS variant in a family with hyperphagia and obesity. Bioscientifica  Endocrine Abstracts   
Popat D, Xu R, McCormick P and Chan L (2023). Gain-of-function mutation F278C in MC2R results in reduced beta-1-arrestin recruitment and increased cAMP implicating impairment of S280 phosphorylation. Bioscientifica  Endocrine Abstracts   
Elhassan Y, Appenzeller S, Landwehr L, Popat D, Gilligan L, Goh E, Diaz-Cano S, Kircher S, Gramlich S, Sutcliffe R, Thangaratinam S, Chan L, Fassnacht M, Arlt W and Ronchi C (2023). Primary unilateral macronodular adrenal hyperplasia (pumah) with concomitant glucocorticoid and androgen excess due to kdm1a activation and constitute mc2r activation. Bioscientifica  Endocrine Abstracts   
Smith C, Abdullah M, Hassan S, Fauzi L, Qamar Y, Hall C, Maitra S, Maharaj A, Marroquin RL, Read J, Chan L, Metherell L and Musa S (2023). Genetic aetiology of primary adrenal insufficiency in Sudan. Bioscientifica  Endocrine Abstracts   
Smith C, Jackson A, Al-Salihi A, Janecke A, Steichen E, Darby D, Griffin L, Banka S, Elsayed S, Chan L and Metherell L (2023). SAT292 Adrenal Insufficiency Associated With Biallelic Mutations In Porphyria Genes. The Endocrine Society  Journal of the Endocrine Society  vol. 7, (Supplement_1)  
Smith C, Abdullah M, Hassan S, Qamar Y, Hall C, Maitra S, Maharaj A, Mariela MRL, Read J, Chan L, Metherell L and Musa S (2023). Genetic Aetiology of Primary Adrenal Insufficiency in Sudan. Bioscientifica  Endocrine Abstracts   
Smith CJ, Chan L and Metherell LA (2023). 769 Reduced expression of PPOX, the variegate porphyria gene, causes intrinsic pathological changes to keratinocytes. Elsevier  Journal of Investigative Dermatology  vol. 143, (5)  
Baksh RA, Pape SE, Chan LF, Aslam AA, Gulliford MC, Strydom A and Consortium G-D (2023). Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records. Elsevier  The Lancet Public Health  vol. 8, (6) e453-e462.  
Hasenmajer V, Ferrigno R, Minnetti M, Pellegrini B, Isidori AM, Lenzi A, Salerno M, Cappa M, Chan L, De Martino MC and Savage MO (2023). Rare forms of genetic paediatric adrenal insufficiency: Excluding congenital adrenal hyperplasia. Springer Nature  Reviews in Endocrine and Metabolic Disorders  vol. 24, (2) 345-363.  
Wells J, Elizalde MT, Saini F, Gomis-González M, Smida IB, Gamazo LF, Chan L, Delahaye AH, Durand S, De La Torre Fornell R and Strydom A (2023). Insulin resistance and symptoms of depression in Down syndrome. Elsevier  Neuroscience Applied  vol. 2,  

2022

Chan L, Smith C, Read J, Hall C, Maharaj A, Ramirez LM, Qamar Y, Hughes C, Clark A, Musa S, Prasad R and Metherell L (2022). RF33 | PSAT69 A Combined Candidate Gene/Whole Exome Sequencing Approach Permits a Rapid Genetic Diagnosis for >81% Individuals with Primary Adrenal Insufficiency. The Endocrine Society  Journal of the Endocrine Society  vol. 6, (Supplement_2) a140-a141.  
Chan L (2022). Identification of a novel specific small-molecule melanocortin-2-receptor antagonist. BioScientifica  Endocrine Connections  vol. 11, (12)  
Aslam A, Baksh A, Pape S, Consortium G-D, Strydom A, Gulliford M and Chan L (2022). Diabetes and obesity in down syndrome across the lifespan: a retrospective cohort study using UK electronic health records. Bioscientifica  Endocrine Abstracts   
Maitra S, Smith C, Hall C, Read J, Maharaj AV, Mariela MRL, Qamar Y, Prasad R, Chan LF and Metherell LA (2022). The lack of genotype: phenotype correlations in rare causes of primary adrenal insufficiency highlights the need for genetic testing. Bioscientifica  Endocrine Abstracts   
Aslam A, Baksh A, Pape S, Strydom A, Gulliford M and Chan L (2022). Diabetes and obesity in Down Syndrome across the lifespan: a retrospective cohort study using UK electronic health records. American Diabetes Association  Diabetes Care   
Parry CM, Chan LF, Carr DF and Hawcutt DB (2022). Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression. Springer Nature  Pediatric Research  vol. 93, (1) 97-101.  
Smith C, Read J, Hall C, Maharaj A, Marroquin RL, Qamar Y, Hughes C, Clark A, Prasad R, Chan L, Musa S and Metherell L (2022). A rapid genetic diagnosis for >80% individuals with non-CAH Primary Adrenal Insufficiency is achievable by candidate gene sequencing combined with WES. Bioscientifica  Endocrine Abstracts   
Baksh RA, Strydom A, Pape SE, Chan LF and Gulliford MC (2022). Susceptibility to COVID-19 Diagnosis in People with Down Syndrome Compared to the General Population: Matched-Cohort Study Using Primary Care Electronic Records in the UK. Springer Nature  Journal of General Internal Medicine  vol. 37, (8) 2009-2015.  
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ and Hobbs AJ (2022). C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis. Proc Natl Acad Sci U S A  vol. 119, (13)  
Chan LF and Ramachandrappa S (2022). Genetics of Adrenal Insufficiency. Oxford Textbook of Endocrinology and Diabetes 3e  Oxford University Press (OUP)   
Baksh RA, Pape SE, Chan LF, Aslam AA, Gulliford MC, Strydom A and Consortium G-D (2022). Multiple Morbidity Across the Lifespan in People with Down Syndrome or Intellectual Disability: Population-Based Cohort Study Using Electronic Health Records. Elsevier  The Lancet Public Health   

2021

Smith C, Maharaj A, Qamar Y, Read J, Williams J, Marimuthu V, Chan L and Metherell L (2021). In vitro splicing assay proves the pathogenicity of intronic variants in MRAP. Bioscientifica  Endocrine Abstracts   
H I, O D, F F, V C, AK G, NJ R, J B, V P, Y P, LF C, D B-Z, PJ M, Y N and M S-B (2021). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling. Bioscientifica   
Maudhoo A, Maharaj A, Buonocore F, Martos-Moreno GA, Argente J, Achermann JC, Chan LF and Metherell LA (2021). Missplicing due to a synonymous, T96= exonic substitution in the T-box transcription factor TBX19 resulting in isolated ACTH deficiency. Bioscientifica  Endocrinology Diabetes and Metabolism Case Reports  vol. 2021, 21-0128.  
Degtjarik O, Israeli H, Chan LF, Ben-Zvi D, Niv MY, McCormick PJ and Shalev-Benami M (2021). To eat or not to eat: cryo-EM structure of melanocortin receptor 4 reveals mechanism of a 'hunger switch' initiating satiety signalling. International Union of Crystallography (IUCr)  Acta Crystallographica Section A: Foundations and advances  vol. 77, (a2) c480-c480.  
Buonocore F, Maharaj A, Qamar Y, Koehler K, Suntharalingham JP, Chan LF, Ferraz-De-Souza B, Hughes CR, Lin L, Prasad R, Allgrove J, Andrews ET, Buchanan CR, Cheetham TD, Crowne EC, Davies JH, Gregory JW, Hindmarsh PC, Hulse T, Krone NP, Shah P, Shaikh MG, Roberts C, Clayton PE, Dattani MT, Thomas NS, Huebner A, Clark AJ, Metherell LA and Achermann JC (2021). Genetic Analysis of Pediatric Primary Adrenal Insufficiency of Unknown Etiology: 25 Years' Experience in the UK. Journal of the Endocrine Society  vol. 5, (8)  
Smith C, Maharaj AV, Qamar Y, Read J, Williams J, Chan L, Marimuthu V and Metherell L (2021). In Vitro Splicing Assay Proves the Pathogenicity of Intronic Variants in MRAP. Journal of the Endocrine Society  vol. 5, (Suppl 1) a85-a86.  
Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY and Shalev-Benami M (2021). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. American Association for the Advancement of Science (AAAS)  Science  vol. 372, (6544) 808-814.  

2020

Maharaj A, Williams J, Bradshaw T, Güran T, Braslavsky D, Casas J, Chan LF, Metherell LA and Prasad R (2020). Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction. Elsevier  The Journal of Steroid Biochemistry and Molecular Biology  vol. 202,  

2019

Qamar Y, Maharaj A, Chan L, AbdulBagi S, Abdullah M and Metherell L (2019). Rare causes of primary adrenal insufficiency (PAI) in children from Sudan. Bioscientifica  Endocrine Abstracts   
Smith C, Maharaj A, Prasad R, Hughes C, Qamar Y, Clark A, Chan L and Metherell L (2019). Twenty-five years of familial glucocorticoid deficiency: genotypic and phenotypic variability. Bioscientifica  Endocrine Abstracts   
Qamar Y, Maharaj A, Chan L, Deeb A and Metherell L (2019). Splice-site mutations in the melanocortin-2 receptor accessory protein that lead to early-onset familial glucocorticoid deficiency type 2. Bioscientifica  Endocrine Abstracts   
Clark AJL and Chan L (2019). Stability and Turnover of the ACTH Receptor Complex. Frontiers  Frontiers in Endocrinology  vol. 10,  
Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL and Chan LF (2019). ACTH signalling and adrenal development: lessons from mouse models. Bioscientifica  Endocrine Connections  vol. -1, (aop) r122-r130.  
Maharaj A, Maudhoo A, Chan LF, Novoselova T, Prasad R, Metherell LA and Guasti L (2019). Isolated glucocorticoid deficiency: Genetic causes and animal models. Journal of Steroid Biochemistry and Molecular Biology  vol. 189, 73-80.  

2018

Maudhoo A, Maharaj A, Buonocore F, Martos-Moreno GA, Argente J, Achermann J, Chan L and Metherell L (2018). Missplicing due to a silent exonic substitution in the T-box transcription factor TBX19 resulting in Isolated ACTH deficiency. Bioscientifica  Endocrine Abstracts   
Chan L, Hussain M, Forfar R, Khurana P, Cook J, Lewis S, McIver E, Jerman J, Taylor D and Clark A (2018). Identification and characterisation of a small-molecule ACTH receptor/Melanocortin-2-receptor antagonist. Bioscientifica  Endocrine Abstracts   
Bruschetta G, Kim JD, Diano S and CHAN L (2018). Overexpression of Melanocortin 2 Receptor Accessory Protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure. Elsevier  Molecular Metabolism   
Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL and Chan LF (2018). MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. Wiley  The FASEB Journal  vol. 32, (11) 6186-6196.  
Novoselova TV, Chan LF and Clark AJL (2018). Pathophysiology of melanocortin receptors and their accessory proteins. Best Pract Res Clin Endocrinol Metab  vol. 32, (2) 93-106.  

2017

Clark AJL and Chan LF (2017). Promiscuity among the MRAPs. BioScientifica  Journal of Molecular Endocrinology  vol. 58, (3) F1-F4.  

2016

CHAN L (2016). A central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity. National Academy of Sciences  Proceedings of the National Academy of Sciences of USA   
Clark AJ, Forfar R, Hussain M, Jerman J, McIver E, Taylor D and Chan L (2016). ACTH Antagonists. Frontiers Media  Frontiers in Endocrinology  vol. 7,  
Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn E, Gorrigan RJ, Tate P, Guasti L, Sanger Mouse Genetics Project T, O'Rahilly S, Clark AJL, Logan DW, Coll AP and Chan LF (2016). Loss of Mrap2 is associated with Sim 1 deficiency and increased circulating cholesterol. Journal of Endocrinology  JOE-16-0057-JOE-16-0057.  

2015

Buonocore F, Chan L, Achermann J and Metherell L (2015). Molecular diagnosis of patients with adrenal insufficiency using a targeted custom Haloplex next-generation sequencing panel. Bioscientifica  Endocrine Abstracts   
Chan LF, Campbell DC, Novoselova TV, Clark AJL and Metherell LA (2015). Whole-Exome Sequencing in the Differential Diagnosis of Primary Adrenal Insufficiency in Children. Frontiers  Frontiers in Endocrinology  vol. 6,  
Jackson DS, Ramachandrappa S, Clark AJ and Chan LF (2015). Melanocortin receptor accessory proteins in adrenal disease and obesity. Frontiers  Frontiers in Neuroscience  vol. 9,  
Novoselova TV, Rath SR, Carpenter K, Pachter N, Dickinson JE, Price G, Chan LF, Choong CS and Metherell LA (2015). NNT Pseudoexon Activation as a Novel Mechanism for Disease in Two Siblings With Familial Glucocorticoid Deficiency. Endocrine Society  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM  vol. 100, (2) E350-E354.  

2014

Novoselova T, Larder R, Rimmington D, Lelliott C, Wynn E, O'Rahilly S, Clark A, Logan D, Coll A and Chan L (2014). Melanocortin 2 receptor accessory protein 2 (Mrap2) regulates hypothalamic melanocortin-4-receptor trafficking in vivo. Bioscientifica  Endocrine Abstracts   
Chan L, Novoselova T, Rath S, Carpenter K, Pachter N, Price G, Dickinson J, Choong C and Metherell L (2014). cDNA analysis reveals NNT pseudoexon activation in two siblings with familial glucocorticoid deficiency. Bioscientifica  Endocrine Abstracts   
Novoselova T, Spoudeas H, Huebner A, Cheetham T, Chan L and Metherell L (2014). Varied clinical presentations of six patients with mutations in CYP11A1 encoding the cholesterol side-chain cleavage enzyme, P450scc. Bioscientifica  Endocrine Abstracts   
Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJL, Storr HL and Metherell LA (2014). Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab  vol. 99, (8) E1556-E1563.  

2013

Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, O’Rahilly S, CHAN L, Clark AJ, Farooqi IS and Majzoub JA (2013). Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity. American Association for the Advancement of Science  Science  vol. 341, (6143) 275-278.  
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Mol Cell Endocrinol  vol. 371, (1-2) 195-200.  
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Molecular and Cellular Endocrinology  vol. 371, (1-2) 195-200.  
Novoselova TV, Jackson D, Campbell DC, Clark AJL and Chan LF (2013). Melanocortin receptor accessory proteins in adrenal gland physiology and beyond. J Endocrinol  vol. 217, (1) R1-11.  
Prasad R, Hughes C, Chan L, Peters C, Nathwani N, Clark A, Storr H and Metherell L (2013). A mutation in thioredoxin reductase 2 (TXNRD2) is associated with a predominantly adrenal phenotype in humans. Bioscientifica  Endocrine Abstracts  1-1.  
Meimaridou E, Hughes CR, Kowalczyk J, Chan LF, Clark AJL and Metherell LA (2013). ACTH resistance: genes and mechanisms. Endocr Dev  vol. 24, 57-66.  
Ramachandrappa S, Gorrigan RJ, Clark AJL and Chan LF (2013). The melanocortin receptors and their accessory proteins. Front Endocrinol (Lausanne)  vol. 4,  

2011

Jain V, Metherell LA, David A, Sharma R, Sharma PK, Clark AJL and Chan LF (2011). Neonatal presentation of familial glucocorticoid deficiency resulting from a novel splice mutation in the melanocortin 2 receptor accessory protein. Eur J Endocrinol  vol. 165, (6) 987-991.  
Chan LF, Metherell LA and Clark AJL (2011). Effects of melanocortins on adrenal gland physiology. EUR J PHARMACOL  vol. 660, (1) 171-180.  
Gorrigan RJ, Guasti L, King P, Clark AJ and Chan LF (2011). Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland. J Mol Endocrinol  vol. 46, (3) 227-232.  
Chan LF, Vaidya M, Westphal B, Allgrove J, Martin L, Afshar F, Hindmarsh PC, Savage MO, Grossman AB and Storr HL (2011). Use of intravenous etomidate to control acute psychosis induced by the hypercortisolaemia in severe paediatric Cushing's disease. Horm Res Paediatr  vol. 75, (6) 441-446.  

2010

Chan L, Albertsson-Wikland K, Camacho-Hübner C and Hochberg Z (2010). Signal transduction in child health: closing the gap between clinical and basic research. Sci Signal  vol. 3, (143)  
Chung T-TLL, Chan LF, Metherell LA and Clark AJL (2010). Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2. Clin Endocrinol (Oxf)  vol. 72, (5) 589-594.  
Dias RP, Kumaran A, Chan LF, Martin L, Afshar F, Matson M, Plowman PN, Monson JP, Besser GM, Grossman AB, Savage MO and Storr HL (2010). Diagnosis, management and therapeutic outcome in prepubertal Cushing's disease. Eur J Endocrinol  vol. 162, (3) 603-609.  
Dias RP, Chan LF, Metherell LA, Pearce SHS and Clark AJL (2010). Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency. Eur J Endocrinol  vol. 162, (2) 357-359.  
Savage MO, Dias RP, Chan LF, Afshar F, Plowman PN, Matson M, Grossman AB and STORR HL (2010). Diagnosis and Treatment of Cushing’s Disease in Children. Pediatric Neuroendocrinology , Editors: Loche S, Cappa M, Ghizzoni L, Maghnie M and Savage MO. Karger Publishers   
Savage MO, Dias RP, Chan LF, Afshar F, Plowman NP, Matson M, Grossman AB and Storr HL (2010). Diagnosis and treatment of Cushing's disease in children. Endocr Dev  vol. 17, 134-145.  

2009

Chan LF, Metherell LA, Krude H, Ball C, O'Riordan SMP, Costigan C, Lynch SA, Savage MO, Cavarzere P and Clark AJL (2009). Homozygous nonsense and frameshift mutations of the ACTH receptor in children with familial glucocorticoid deficiency (FGD) are not associated with long-term mineralocorticoid deficiency. Clin Endocrinol (Oxf)  vol. 71, (2) 171-175.  
Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA and Clark AJL (2009). MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A  vol. 106, (15) 6146-6151.  
Chan LF, Chung T-T, Massoud AF, Metherell LA and Clark AJL (2009). Functional consequence of a novel Y129C mutation in a patient with two contradictory melanocortin-2-receptor mutations. Eur J Endocrinol  vol. 160, (4) 705-710.  
Clark AJL, Chan LF, Chung T-T and Metherell LA (2009). The genetics of familial glucocorticoid deficiency. Best Pract Res Clin Endocrinol Metab  vol. 23, (2) 159-165.  
Cooray SN, Chan L, Webb TR, Metherell L and Clark AJL (2009). Accessory proteins are vital for the functional expression of certain G protein-coupled receptors. Mol Cell Endocrinol  vol. 300, (1-2) 17-24.  
Webb TR, Chan L, Cooray SN, Cheetham ME, Chapple JP and Clark AJL (2009). Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking. Endocrinology  vol. 150, (2) 720-726.  
Metherell LA, Chung TT, Chan LF and Clark AJL (2009). Genotype:phenotype relationships in familial glucocorticoid deficiency types 1 and 2. HORM RES  vol. 72, 211-211.  
Chan LF, David A, Jain V, Clark AJL and Metherell LA (2009). A novel splice mutation (IVSds3+3insTA) in the melanocortin 2 receptor accessory protein that leads to skipping of exon 3. HORM RES  vol. 72, 70-70.  
Dias RP, Kumaran A, Chan LF, Martin L, Afshar F, Matson M, Plowman PN, Monson JP, Besser GM, Grossman AB, Savage MO and Storr HL (2009). Prepubertal Cushing's disease: diagnosis, management and therapeutic outcome. HORMONE RESEARCH  vol. 72, 72-72.  
Chan LF, Metherell LA, Krude H, Ball C, O'Riordan SM, Costigan C, Lynch SA, Savage MO, Cavarzere P and Clark AJ (2009). Homozygous nonsense and frameshift mutations of the ACTH receptor in children with familial glucocorticoid deficiency (FGD) are not associated with long-term mineralocorticoid deficiency. Clin Endocrinol (Oxf)  vol. 71, (2) 171-175.  

2008

Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP and Clark AJL (2008). The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface. J Clin Endocrinol Metab  vol. 93, (12) 4948-4954.  
Savage MO, Chan LF, Grossman AB and Storr HL (2008). Work-up and management of paediatric Cushing's syndrome. Curr Opin Endocrinol Diabetes Obes  vol. 15, (4) 346-351.  
O'Riordan SMP, Lynch SA, Hindmarsh PC, Chan LF, Clark AJL and Costigan C (2008). A novel variant of familial glucocorticoid deficiency prevalent among the Irish traveler population. J CLIN ENDOCR METAB  vol. 93, (7) 2896-2899.  
O'Riordan SMP, Lynch SA, Hindmarsh PC, Chan LF, Clark AJL and Costigan C (2008). A novel variant of familial glucorticoid deficiency prevalent among the Irish traveler population. J Clin Endocrinol Metab.  vol. 93, (7) 2896-2899.  
Chan LF, Clark AJL and Metherell LA (2008). Familial glucocorticoid deficiency: advances in the molecular understanding of ACTH action. Horm Res  vol. 69, (2) 75-82.  
Cooray SN, Chan L, Metherell L, Storr H and Clark AJL (2008). Adrenocorticotropin resistance syndromes. Endocr Dev  vol. 13, 99-116.  
Storr H, Alexandraki K, Chan L, Martin L, Monson J, Besser M, Grossman A and Savage M (2008). Comparisons in the epidemiology and diagnostic features between paediatric and adult Cushing's disease. HORM RES  vol. 70, 24-25.  
Chan L, Chung TT, Massoud A, Metherell L and Clark A (2008). Functional consequence of two opposing MC2R mutations in a child with severe FGD phenotype. HORM RES  vol. 70, 23-23.  
Savage MO, Chan LF, Afshar F, Plowman PN, Grossman AB and Storr HL (2008). Advances in the management of paediatric Cushing's disease. Horm Res  vol. 69, (6) 327-333.  

2007

Chan LF, Storr HL, Grossman AB and Savage MO (2007). Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. Arq Bras Endocrinol Metabol  vol. 51, (8) 1261-1271.  
Storr HL, Chan LF, Grossman AB and Savage MO (2007). Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances. TRENDS ENDOCRIN MET  vol. 18, (4) 167-174.  
Chan LF, Storr HL, Plowman PN, Perry LA, Besser GM, Grossman AB and Savage MO (2007). Long-term anterior pituitary function in patients with paediatric Cushing's disease treated with pituitary radiotherapy. EUR J ENDOCRINOL  vol. 156, (4) 477-482.  
Savage MO, Storr HL, Chan LF and Grossman AB (2007). Diagnosis and treatment of pediatric Cushing's disease. Pituitary  vol. 10, (4) 365-371.  

2006

Metherell LA, Chan LF and Clark AJL (2006). The genetics of ACTH resistance syndromes. Best Pract Res Clin Endocrinol Metab  vol. 20, (4) 547-560.  
Chan L, Storr H, Plowman PN, Perry L, Monson J, Besser GM, Grossman A and Savage M (2006). Anterior pituitary function in the long-term follow-up of five paediatric Cushing's disease patients treated with pituitary radiotherapy. HORM RES  vol. 65, 186-186.  

2004

Chan LF, Storr HL, Scheimberg I, Perry LA, Banerjee K, Miraki-Moud F, Camacho-Hubner C and Savage MO (2004). Pseudo-precocious puberty caused by a juvenile granulosa cell tumor secreting androstenedione, inhibin and insulin-like growth factor-I. J PEDIATR ENDOCR MET  vol. 17, (4) 679-684.  
Chan L and Hodes D (2004). When is an abnormal frenulum a sign of child abuse? Arch Dis Child  vol. 89, (3)  

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconStudying Genetic Predisposition Towards Obesity in Down Syndrome Using Polygenic Risk Scores
Li Chan and Panagiotis Deloukas
£151,868 Daphne Jackson Trust, the (02-05-2023 - 01-05-2026)
solid heart iconInvestigating the mechanism of adrenal insufficiency in individuals with porphyria
Louise Metherell and Li Chan
£331,824 MRC Medical Research Council (14-02-2023 - 13-02-2026)
solid heart iconAdrenal insufficiency in association with mutations in genes causing porphyria
Louise Metherell and Li Chan
£248,292 Barts and the London Charity (01-10-2022 - 31-03-2025)
bullet iconBarts Metabolism Network -Regulating brown fat thermogenesis and white fat beigeing to treat obesity and its co-morbidities
Li Chan
£498,545 Barts and the London Charity (01-04-2022 - 31-03-2025)
bullet iconGene overdosage and comorbidities over early lifetime in Down Syndrome

£484,754 EU Commission - Horizon 2020 (01-01-2020 - 30-06-2025)


bullet iconMolecular characterisation of MC2R/MRAPantagonists for the treatment of ACTH excess inpituitary (MRC Icase)
Li Chan
£17,500 OMASS Therapeutics Ltd (21-09-2020 - 20-03-2024)
bullet iconAdrenal dysfunction and obesity in Down Syndrome

£111,566 Wellcome Trust (20-01-2020 - 20-10-2021)
solid heart iconImproved genetic diagnosis of primary adrenal insufficiency
and
£525,022 Barts and the London Charity (01-08-2018 - 31-01-2023)
bullet iconIn vivo characterisation of ACTH rececptor antagonists

£76,780 ESPE European Society for Paediatric Endocrinology (30-07-2018 - 30-06-2021)