Dr William Alazawi
Reader & Consultant in Hepatology
Blizard Institute
Queen Mary University of London
Queen Mary University of London
Publications
2026
Use of fibroscan assessment to determine MASLD in a diverse paediatric obesity cohortBolton O, Peh G, Shah P, P DA, Salam Z, Xu R, Scroth J, M HS et al.
Endocrine Abstracts, Bioscientifica
13-02-2026
Cardiovascular Risk in MASLD: What Multiple Lines of Evidence RevealSattar N, Dalakoti M, Alazawi W, Aroda VR
Journal of Hepatology, Elsevier
01-02-2026
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP MechanotransductionMa J, Xie N, Wang Z, Liang X, Han Y, Zhao Q, Wang M, Lu H et al.
Advanced Science, Wiley vol. 13 (19)
04-01-2026
2025
Doubling the diagnostic rate of at-risk metabolic dysfunction-associated steatohepatitis—leave no one behind: author's replyLazarus JV, Alazawi W, Byrne CD, Caussy C, Brennan PN
The Lancet Regional Health - Europe, Elsevier vol. 60
26-12-2025
Diagnostic Performance of LIVERFASt as a Non-invasive Liver Fibrosis Test: Data from Three Cohorts of Patients with Metabolic Dysfunction-associated Steatotic Liver Disease.Alkhouri N, Mantry P, Gonzalez HC, Patil R, McIntyre V, Kohli A, Rudraraju M, Kosinski JF et al.
Journal of Gastrointestinal and Liver Diseases, Romanian Society of Gastroenterology and Hepatology vol. 34 (4), 437-450.
26-12-2025
Real-world evidence in metabolic dysfunction-associated steatotic liver disease (MASLD): insights, challenges, and future directionsHuang H-T, Hewitt M, Li W, Alazawi W
The Lancet Regional Health - Europe, Elsevier vol. 62
13-12-2025
Nutrition in MASLD: a patient focused, evidence-based clinician’s guidePekarska K, Brennan PN, Wajcman DI, Towey J, Cox L, Weatherby K, McPherson S, Stine J et al.
Frontline Gastroenterology, Bmj vol. 17 (3)
30-11-2025
Current and emerging therapeutic landscape for metabolic dysfunction-associated steatohepatitisLi W, Alazawi W, Loomba R
The Lancet Gastroenterology & Hepatology, Elsevier vol. 11 (2), 150-162.
27-11-2025
Metabolic dysfunction-associated steatotic liver diseaseHsu C, Alazawi W
Clinical Medicine, Elsevier vol. 25 (6)
25-10-2025
P69 Tapping into trouble: delays in diagnostic paracentesis in decompensated cirrhosisMiller H, Temperley L, Khanna K, Phillips A, Patel K, Wells G, Hearn T, Diver W et al.
P69 Tapping into trouble: delays in diagnostic paracentesis in decompensated cirrhosis.
01-10-2025
P13 Baseline characteristics in well-compensated NASH cirrhosis patients diagnosed with or without a liver biopsy in MAESTRO-NASH-OUTCOMES, a clinical outcome Phase 3 study assessing the effect of resmetirom in well compensated NASH cirrhosisAlazawi W
P13 Baseline characteristics in well-compensated NASH cirrhosis patients diagnosed with or without a liver biopsy in MAESTRO-NASH-OUTCOMES, a clinical outcome Phase 3 study assessing the effect of resmetirom in well compensated NASH cirrhosis.
01-10-2025
P11 Dietary patterns, physical activity levels and mental health status of patients with metabolic dysfunction-associated steatotic liver disease living in East LondonCox L, Imran H, Lim TY, Brindley JH, Muchelemba E, Alazawi W, Sharma V
P11 Dietary patterns, physical activity levels and mental health status of patients with metabolic dysfunction-associated steatotic liver disease living in East London.
01-10-2025
P5 Pegozafermin treatment demonstrates long-term benefit in subjects with metabolic dysfunction-associated steatohepatitis and fibrosis: results from the Phase 2b ENLIVEN clinical trialAlazawi W, Sanyal AJ, Schattenberg J, Feng S, Gottwald MD, Mansbach H, Margalit M, Hartsfield C et al.
P5 Pegozafermin treatment demonstrates long-term benefit in subjects with metabolic dysfunction-associated steatohepatitis and fibrosis: results from the Phase 2b ENLIVEN clinical trial.
01-10-2025
P91 Multidisciplinary one-stop diagnostic liver clinic delivers 46% discharge rate at first appointmentKerry G, Brindley JH, Lim TY, Cox L, Muchelemba E, Sharma V, Alazawi W
P91 Multidisciplinary one-stop diagnostic liver clinic delivers 46% discharge rate at first appointment.
01-10-2025
Epidemiology of Metabolic Dysfunction–Associated Steatotic Liver Disease in South Asian Ethnicities: A Systematic Review and Meta‐AnalysisJames M, Smuk M, Rahman N, Black G, Alazawi W
Journal of Gastroenterology and Hepatology, Wiley vol. 40 (12), 2830-2841.
26-09-2025
The People-First Liver CharterLazarus JV, Ivancovsky Wajcman D, Pannain S, Brennan PN, Manolas MI, Jepsen P, Treloar C, Arora AK et al.
Nature Medicine, Springer Nature vol. 31 (7), 2109-2116.
05-06-2025
A call for doubling the diagnostic rate of at-risk metabolic dysfunction-associated steatohepatitisLazarus JV, Brennan PN, Mark HE, Alazawi W, Allen AM, Byrne CD, Castera L, Caussy C et al.
The Lancet Regional Health - Europe, Elsevier vol. 54
04-06-2025
FP13 The urine steroid metabolome combined with machine learning performs similarly to established non-invasive markers to identify advanced MASLD fibrosisMiller H, Brandhof EVD, Simpson J, Denham S, Harman D, Aithal GP, Manousou P, Cobbold J et al.
Flash Presentations.
01-06-2025
High inherited risk predicts age-associated increases in fibrosis in patients with MASLDDíaz LA, Alazawi W, Agrawal S, Arab JP, Arrese M, Idalsoaga F, Barreyro FJ, Gadano A et al.
Journal of Hepatology, Elsevier vol. 83 (4), 849-859.
05-05-2025
TOP-441 CD8+ T cells are pro-inflammatory, cytotoxic, and clonally expanded in the early stages of fibrosis due to metabolic dysfunction-associated steatohepatitis (MASH)Kumar R, Li W, Loy J, Devalia K, Goralcyzk A, Malik H, James L, Marelli-Berg F et al.
Journal of Hepatology, Elsevier vol. 82
01-05-2025
WED-419 The urine steroid metabolome combined with machine learning performs similarly to established non-invasive markers to risk stratify for the presence of advanced MASLD fibrosisMiller H, van den Brandhof E, Simpson J, Denham S, Harman D, Aithal G, Manousou P, Cobbold J et al.
Journal of Hepatology, Elsevier vol. 82, s550-s551.
01-05-2025
THU-025-YI Prevalence of and outcomes related to metabolic dysfunction-associated steatotic liver disease (MASLD) in a nationwide cohort: insights from over 23 million individuals in Taiwan’s national health insurance research databaseHuang H-T, Lin L-Y, Lee C-P, Hewitt M, Chaplin C, Yang Y-H, Alazawi W
Journal of Hepatology, Elsevier vol. 82
01-05-2025
An Expert Consensus Delphi Panel in Metabolic Dysfunction- and Alcohol-associated Liver Disease: Opportunities and Challenges in Clinical PracticeDiaz LA, Ajmera V, Arab JP, Huang DQ, Hsu C, Lee BP, Louvet A, Thiele M et al.
Clinical Gastroenterology and Hepatology, Elsevier vol. 24 (3), 633-645.e4.
30-04-2025
Current Surveillance Strategy Is Less Effective for Detecting Early-Stage Hepatocellular Carcinoma in Patients with Non-Viral and Non-Cirrhotic Liver DiseaseSpiers J, Li W, Aravinthan AD, Bannaga A, Caddick K, Culver EL, Faulkes RE, Gordon V et al.
Liver Cancer, Karger Publishers vol. 14 (5), 587-600.
26-03-2025
A European Survey to Identify Challenges in the Management of Metabolic Dysfunction‐Associated Steatotic Liver DiseaseCastera L, Alazawi W, Bugianesi E, Caussy C, Federici M, Schattenberg JM, Basuroy R
Liver International, Wiley vol. 45 (2)
03-01-2025
Metabolic dysfunction over a life course key to healthy ageing inequalityLittlewood K, Gegic J, Hickman M, Henson RCJ, Bishop JR, Kershaw T, Diamond P, Slabaugh G et al.
Aging Clinical and Experimental Research, Springer Nature vol. 37 (1)
01-01-2025
2024
Endogenous C-type natriuretic peptide offsets the pathogenesis of steatohepatitis, hepatic fibrosis, and portal hypertensionPerez-Ternero C, Li W, Aubdool AA, Goldin RD, Loy J, Devalia K, Alazawi W, Hobbs AJ
Pnas Nexus, Oxford University Press (Oup) vol. 4 (1)
23-12-2024
A social media listening study of patients’ experiences relating to metabolic dysfunction-associated steatotic liver disease: The LISTEN-MASLD studyLazarus JV, Alazawi W, Basuroy R, Castera L, Koulla Y, Prasad P, Romero-Gomez M
Annals of Hepatology, Elsevier vol. 30 (1)
02-12-2024
Glycated haemoglobin is a major predictor of disease severity in patients with NAFLDColosimo S, Miller H, Koutoukidis DA, Marjot T, Tan GD, Harman DJ, Aithal GP, Manousou P et al.
Diabetes Research and Clinical Practice, Elsevier vol. 217
13-08-2024
Update on Treatment for Metabolic Dysfunction-Associated Steatohepatitis Cirrhosis.Alazawi W
Gastroenterology & Hepatology vol. 20 (4), 241-243.
01-04-2024
Progress is impossible without change: understanding the evolving nomenclature of steatotic liver disease and its effect on hepatology practiceBrennan PN, Tavabie OD, Li W, Marjot T, Corless L, Fallowfield JA, Jarvis H, Mansour D et al.
The Lancet Gastroenterology & Hepatology, Elsevier vol. 9 (6), 577-582.
28-02-2024
Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation studyMiller H, Harman D, Aithal GP, Manousou P, Cobbold JF, Parker R, Sheridan D, Newsome PN et al.
Bmj Open, Bmj vol. 14 (1)
01-01-2024
2023
The role of glycated haemoglobin in predicting disease severity in non-alcoholic fatty liver diseaseColosimo S, Miller H, Koutoukidis D, Marjot T, Harman D, Aithal G, Manousou P, Forlano R et al.
Endocrine Abstracts, Bioscientifica
31-10-2023
Non-invasive Tests of Fibrosis: Does One Size Fit All?James M, Alazawi W
Digestive Diseases and Sciences, Springer Nature vol. 68 (12), 4285-4286.
04-10-2023
Automated and reproducible cell identification in mass cytometry using neural networksSaihi H, Bessant C
Briefings in Bioinformatics, Oxford University Press (Oup) vol. 24 (6)
22-09-2023
National study of NAFLD management identifies variation in delivery of care in the UK between 2019 to 2022Li W, Sheridan D, McPherson S, Alazawi W, Abeysekera K, Marjot T, Brennan P, Mahgoub S et al.
Jhep Reports, Elsevier vol. 5 (12)
28-08-2023
A global action agenda for turning the tide on fatty liver diseaseLazarus JV, Mark HE, Allen AM, Arab JP, Carrieri P, Noureddin M, Alazawi W, Alkhouri N et al.
Hepatology, Wolters Kluwer vol. 79 (2), 502-523.
04-08-2023
A global research priority agenda to advance public health responses to fatty liver diseaseLazarus JV, Mark HE, Allen AM, Arab JP, Carrieri P, Noureddin M, Alazawi W, Alkhouri N et al.
Journal of Hepatology, Elsevier vol. 79 (3), 618-634.
20-06-2023
Measuring NAFLD models of careAllen AM, Younossi ZM, Tsochatzis EA, Zelber-Sagi S, Cusi K
Nature Reviews Gastroenterology & Hepatology, Springer Nature vol. 20 (10), 626-627.
08-06-2023
Feasibility and acceptability of a primary care liver fibrosis testing pathway centred on the diabetes annual review: PRELUDE1 prospective cohort study protocolBrindley JH, Abeysekera K, Hood G, Jennings S, Moore J, Hickman M, Alazawi W
Bmj Open, Bmj vol. 13 (5)
01-05-2023
Renal dysfunction in liver diseaseFaloon S, Alazawi W
Medicine, Elsevier vol. 51 (J Hepatol 62 2015), 288-292.
01-04-2023
2022
Single-cell phenotypes of peripheral blood immune cells in early and late stages of non-alcoholic fatty liver diseaseWaller KJ, Saihi H, Li W, Brindley JH, De Jong A, Syn W-K, Bessant C, Alazawi W
Clinical and Molecular Hepatology, The Korean Association For The Study of The Liver vol. 29 (2), 417-432.
21-11-2022
Myeloid XBP1 links lipid overload with inflammation in NASH: Do advances in basic science have clinical potential?Alazawi W
Journal of Hepatology, Elsevier vol. 77 (2), 290-292.
11-06-2022
What’s new in non-alcoholic fatty liver disease?Spiers J, Brindley JH, Li W, Alazawi W
Frontline Gastroenterology, Bmj vol. 13 (e1), e102-e108.
31-05-2022
Association of gamma-glutamyltransferase levels with total mortality, liver-related and cardiovascular outcomes: A prospective cohort study in the UK BiobankHo FK, Ferguson LD, Gray SR, Forrest E, Gill JM, Katikireddi SV, Cleland JG, Pell JP
Eclinicalmedicine, Elsevier vol. 48
12-05-2022
Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest GroupMcPherson S, Armstrong MJ, Cobbold JF, Corless L, Anstee QM, Aspinall RJ, Barclay ST, Brennan PN et al.
The Lancet Gastroenterology & Hepatology, Elsevier vol. 7 (8), 755-769.
28-04-2022
The contribution of daytime sleepiness to impaired quality of life in NAFLD in an ethnically diverse populationLi W, Kadler BK, Brindley JH, Hood G, Devalia K, Loy J, Syn W-K, Alazawi W
Scientific Reports, Springer Nature vol. 12 (1)
24-03-2022
Identification of liver disease: why and howMacpherson I, Abeysekera KWM, Harris R, Mansour D, McPherson S, Rowe I, Dillon JF
Frontline Gastroenterology, Bmj vol. 13 (5), 367-373.
24-01-2022
The growing prevalence of nonalcoholic fatty liver disease (NAFLD), determined by fatty liver index, amongst young adults in the United States. A 20-year experienceLi W, Ng CH, Quek J, Chan KE, Tan C, Zeng RW, Yong JN, Tay H et al.
Metabolism and Target Organ Damage, Oae Publishing vol. 2 (4), null-null.
01-01-2022
2021
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. Reply.Gordon AC, Angus DC, Derde LPG
New England Journal of Medicine vol. 385 (12), 1147-1149.
18-08-2021
Undiagnosed obstructive sleep apnoea is a major component in NAFLD quality of life impairmentLi W, Kadler BK, Brindley JH, Berryman V, Preston J, Pattrick M, Sutcliffe C, Hood G et al.
01-01-2021
2020
Non-alcoholic fatty liver diseaseLi W, Alazawi W
Clinical Medicine, Elsevier vol. 20 (5), 509-512.
01-09-2020
Socioeconomic Factors Associated With Liver-Related Mortality From 1985 to 2015 in 36 Developed CountriesLi W, Kemos P, Salciccioli JD, Marshall DC, Shalhoub J, Alazawi W
Clinical Gastroenterology and Hepatology, Elsevier vol. 19 (8), 1698-1707.e13.
22-08-2020
THU047 Serious complications due to study-mandated liver biopsies in phase 3 trials for patients with advanced fibrosis due to non-alcoholic steatohepatitisAnstee Q, Patel K, Laurent C, Shiffman M, M M, Chen C-Y, George Goh BB, Alazawi W et al.
Journal of Hepatology, Elsevier vol. 73
01-08-2020
SAT022 Simultaneous intra-operative sampling from multiple anatomical sites reveals pro-inflammatory liver homing T cells in liver, adipose tissue and peripheral blood in patients with NASHBrindley J, Tailor F, Waller K, Jong AV-D, Devalia K, Alazawi W
01-08-2020
FRI264 Improvements in the ELF test are associated with widespread changes in the hepatic transcriptome in patients with advanced fibrosis due to non-alcoholic steatohepatitisYounossi ZM, Anstee Q, Harrison S, Trauner M, Lawitz E, Wong VW-S, Okanoue T, Gomez MR et al.
Journal of Hepatology, Elsevier vol. 73, s528-s530.
01-08-2020
Stat2 loss disrupts damage signalling and is protective in acute pancreatitisHeath H, Britton G, Kudo H, Renney G, Ward M, Hutchins R, Foster GR, Goldin RD et al.
The Journal of Pathology, Wiley vol. 252 (1), 41-52.
23-07-2020
Improving prevention strategies for cardiometabolic diseaseSattar N, Alazawi W
Nature Medicine, Springer Nature vol. 26 (3), 320-325.
01-03-2020
Genetics of Non-Alcoholic Fatty Liver and Cardiovascular Disease: Implications for Therapy?Chandrasekharan K
Frontiers in Pharmacology, Frontiers vol. 10
08-01-2020
Proteomic screening of plasma identifies potential noninvasive biomarkers associated with significant/advanced fibrosis in patients with nonalcoholic fatty liver diseaseHou W, Janech MG, Sobolesky PM, Bland AM, Samsuddin S
Bioscience Reports, Portland Press vol. 40 (1)
03-01-2020
IMPACT ON INFLAMMATORY BIOMARKERS, LIPIDS, AND CARDIOVASCULAR SAFETY OF CENICRIVIROC WITH OR WITHOUT STATINS IN SUBJECTS WITH NASH AND SIGNIFICANT LIVER FIBROSIS: CENTAUR STUDYKowdley KV, Alazawi W, Lanthier N, Iacob A, Torstenson R, Seyedkazemi S
01-01-2020
Nonalcoholic Fatty Liver DiseaseAlazawi W
In Liver Immunology, Springer Nature 325-334.
01-01-2020
2019
Obesity Predicts Liver Function Testing and Abnormal Liver ResultsLi W, Homer K, Hull S, Boomla K, Robson J, Alazawi W
Obesity, Wiley vol. 28 (1), 132-138.
05-12-2019
Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trialYounossi ZM, Ratziu V, Loomba R, Rinella M, Anstee QM, Goodman Z, Bedossa P, Geier A et al.
The Lancet, Elsevier vol. 394 (10215), 2184-2196.
01-12-2019
Authors’ reply to McKenna-Barry and RyanSattar N
The Bmj, Bmj vol. 367
22-11-2019
Non‐alcoholic fatty liver disease in menMichael E, Alazawi W
Trends in Urology & Men's Health, Wiley vol. 10 (6), 6-9.
01-11-2019
Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adultsAlexander M, Loomis AK, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Lapi F, Rijnbeek P et al.
The Bmj, Bmj vol. 367
08-10-2019
Renal dysfunction in liver diseaseMichael E, Nadarajah L, Alazawi W
Medicine, Elsevier vol. 47 (Hepatol [Internet] 3), 679-683.
01-10-2019
ADAM17-Mediated Reduction in CD14++CD16+ Monocytes ex vivo and Reduction in Intermediate Monocytes With Immune Paresis in Acute Pancreatitis and Acute Alcoholic HepatitisWaller K, James C, de Jong A, Blackmore L, Ma Y, Stagg A, Kelsell D, O'Dwyer M et al.
Frontiers in Immunology, Frontiers vol. 10
27-08-2019
Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohortsAlexander M, Loomis AK, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Pasqua A, Lapi F et al.
Bmc Medicine, Springer Nature vol. 17 (1)
20-05-2019
FRI-356-Single cell peripheral innate and adaptive immune signature of non-alcoholic steatohepatitis by cytometry time of flightWaller K, Jong AV-D, Li W, Lowe R, Kemos P, Syn W-K, Alazawi W
01-04-2019
FRI-279-Stat2 is a pathogenic factor in human non-alcoholic steatohepatitis and mouse models of liver injury and mediates fatty acid-induced Inflammasome activation in hepatocytesLi W, Britton G, Kudo H, Goldin RD, Alazawi W
01-04-2019
THU-315-Non-cirrhotic patients with non-alcoholic fatty liver disease have impaired quality of life: Independently predicted by body mass index, diabetes and liver stiffnessKadler B, Brindley JH, Berryman V, Preston J, Syn W-K
01-04-2019
2018
Factors influencing longitudinal changes of circulating liver enzyme concentrations in subjects randomized to placebo in four clinical trialsNunez DJ, Alexander M, Yerges-Armstrong L, Singh G, Byttebier G, Fabbrini E, Waterworth D, Wallentin L et al.
Ajp Gastrointestinal and Liver Physiology, American Physiological Society vol. 316 (3), g372-g386.
29-11-2018
Real-world data reveal a diagnostic gap in non-alcoholic fatty liver diseaseAlexander M, Loomis AK, Fairburn-Beech J, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Pasqua A et al.
Bmc Medicine, Springer Nature vol. 16 (1)
13-08-2018
PS-062 Prevalence and explanatory factors for liver function testing and abnormality in a population-based study of children and young peopleLi W, Homer K, Boomla K, Robson J, Hull S, Alazawi W
01-04-2018
SAT-018 The pathogenic role of Stat2 in inflammation is independent of canonical interferon signaling and is mediated by TNFaHeath H, Kudo H, Renney G, Ward M, Cutillas P, Goldin RD, Hutchins R, Foster G et al.
01-04-2018
FRI-423 Non-invasive liver tests in electronic health records of patients with non-alcoholic fatty liver disease: combined analysis from four European countriesDhalwani N, Alexander M, Loomis K, Sattar N, Waterworth D, Mosseveld M, Rijnbeek P, van der Lei J et al.
01-04-2018
PS-106 Non-alcoholic fatty liver disease and relative risk of incident steatohepatitis, cirrhosis and hepatocellular carcinoma events in four European primary care databasesAlexander M, Loomis K, Dhalwani N, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Pasqua A et al.
01-04-2018
Interfering with Kupffer cell replenishment: New insights into liver injuryAlazawi W, Knolle PA
Journal of Hepatology, Elsevier vol. 68 (4), 635-637.
17-02-2018
Stat2 Deletion Impairs MAPK Signaling, NF-Kb Localisation to the Nucleus, Cytokine Expression and Is Protective from Sterile InflammationHeath H, Britton G, Kudo H, Renney G, Ward M, Goldin RD, Hutchins R, Foster GR et al.
01-01-2018
Factors Influencing Global Trends in Liver-Related Mortality - an Observational Study from 1985 to 2015Li W, Salciccioli JD, Marshall D, Shalhoub J, Alazawi W
01-01-2018
Non-Alcoholic Fatty Liver Disease and Risk of Acute Myocardial Infarction and Stroke: Analysis of 18 Million Patients in Four European Primary Care Databases.Alexander M, Loomis K, Dhalwani N, Van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Pasqua A et al.
01-01-2018
Primary care recorded NAFLD and the risk of incident MI and stroke: Findings from analyses of 18 million patients in the UK, the Netherlands, Spain, and ItalyAlexander M, Loomis KA, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Lapi F, Rijnbeek P et al.
01-01-2018
Body mass index and the risk of cardiovascular disease and all-cause mortality in European primary care databasesAlexander M, Dhalwani NN, Rijnbeek P, Mosseveld M, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D et al.
01-01-2018
2017
Periodontitis is associated with significant hepatic fibrosis in patients with non-alcoholic fatty liver diseaseAlazawi W, Bernabe E, Tai D, Kemos P, Turner W
Plos One, Public Library of Science (Plos) vol. 12 (12)
08-12-2017
Non-invasive markers of liver fibrosis in fatty liver disease are unreliable in people of South Asian descentDe Silva S, Li W, Kemos P, Brindley JH, Mecci J, Samsuddin S, Chin-Aleong J, Feakins RM et al.
Frontline Gastroenterology, Bmj vol. 9 (2)
16-11-2017
PWE-075 Non-invasive markers of liver fibrosis in fatty liver disease are unreliable in people of south asian descentDe Silva S, Li W, Kemos P, Brindley J, Mecci J, Samsuddin S, Chin-Aleong J, Feakins R et al.
Liver.
17-06-2017
OC-080 Stat2 is a key mediator of acute pancreatitisHeath H, Renney G, Ward M, Cutillas P, Kudu H, Goldin R, Hutchins R, Foster G et al.
Science Masterclass: Signalling in Epithelial Cancer and Inflammation – Gastric.
17-06-2017
Care standards for non-alcoholic fatty liver disease in the United Kingdom 2016: a cross-sectional surveySheridan DA, Aithal G, Alazawi W, Allison M, Anstee Q, Cobbold J, Khan S, Fowell A et al.
Frontline Gastroenterology, Bmj vol. 8 (4)
28-04-2017
Methotrexate Hepatotoxicity and the Impact of Nonalcoholic Fatty Liver DiseaseShetty A, Cho W
The American Journal of The Medical Sciences, Elsevier vol. 354 (2), 172-181.
14-03-2017
SAT-321 Periodontitis is strongly associated with NAFLD in the NHANES III cohort and in an independent prospective study, is more common in those with biopsy-proven advanced compared to mild liver diseaseAlazawi W, Tai DF, Kemos P, Bernabe E, Janicki T, Gillam D, Syn WK
01-01-2017
SAT-320 Blood-test based assessment of liver fibrosis, but not transient elastography, is less accurate in NAFLD patients of South Asian compared to White ethnicityDe Silva S, Li W, Kemos P, Brindley JH, Feakins R, Chinaleong J, Samsuddin S, Foster GR et al.
01-01-2017
LBP-541 Hepatic fibrosis is associated with histological activity in nonalcoholic steatohepatitis: an analysis from a large database of screening biopsies in the CENTAUR trialRatziu V, Wong VW-S, Lanthier N, Boursier J, Alazawi W, Kluwe J, Genesca J, Andreone P et al.
01-01-2017
LBP-528 Incidence and prevalence of recorded non-alcoholic fatty liver disease in four large European primary care databases covering 21.9 million adultsAlexander M, Loomis K, Fairburn-Beech J, van der Lei J, Duarte-Salles T, Ansell D, Pasqua A, Rijnbeek P et al.
01-01-2017
2016
Inflammatory and Immune Responses to Surgery and Their Clinical ImpactAlazawi W, Pirmadjid N, Lahiri R
Annals of Surgery, Wolters Kluwer vol. 264 (1), 73-80.
01-07-2016
PWE-144 Predicting Treatment Failure in C.Difficile Infection: A Prospective Observational Cohort StudyJoshi N, Goodhand J, Alazawi W, Wilks M, Rampton D
BSG 2016.
01-06-2016
Systemic Inflammatory Response Syndrome After Major Abdominal Surgery Predicted by Early Upregulation of TLR4 and TLR5Lahiri R, Derwa Y, Bashir Z, Giles E, Torrance HDT, Owen HC, O’Dwyer MJ, O’Brien A et al.
Annals of Surgery, Wolters Kluwer vol. 263 (5), 1028-1037.
01-05-2016
2015
PTH-102 Stat2 is a key inflammatory molecule in human non-alcoholic fatty liver disease and murine liver injuryAlazawi W, Heath H, Petts G, Kudu H, Feakins R, O’Brien A, Goldin R, Foster G
Liver – Basic Science.
01-06-2015
PTU-117 Sequential NUC therapy following pegylated interferon provides a greater decline in HBSAG and potentially offers a treatment advantage over current therapiesGill, Hansi N, Payaniandy L, Schulz J, Payaniandy D, Alazawi W, Dearden J, Kallis Y et al.
Liver – Viral Hepatitis.
01-06-2015
PTH-093 One year mortality outcomes of patients with liver cirrhosis admitted to a teaching hospital intensive care unitTai D, Lewis H, Derwa Y, Lillis A, Reynolds T, Maitland K, Hall D, Alazawi W et al.
01-06-2015
P0001 : Early monocyte dysfunction in patients who develop Systemic Inflammatory Response Syndrome (SIRS) and sepsis after hepatopancreaticobiliary surgeryLahiri R, Derwa Y, Bashir Z, Giles E, Torrance H, O’Dwyer M, Owen H, O’Brien A et al.
01-04-2015
Practical approach to non‐alcoholic fatty liver disease in patients with diabetesTai FWD, Syn W-K
Diabetic Medicine, Wiley vol. 32 (9), 1121-1133.
18-03-2015
Association Between Early Postoperatively Elevated TLR-4 & TLR-5 Gene Expression and Late Nosocomial Infection in Elective High-Risk Hepato-Pancreato-Biliary (HPB) SurgeryPirmadjid N, Torrance HDT, Owen HC, Alazawi W
01-01-2015
2014
Research into practice: understanding ethnic differences in healthcare usage and outcomes in general practiceHull S, Mathur R, Boomla K, Chowdhury TA, Dreyer G, Alazawi W, Robson J
British Journal of General Practice, Royal College of General Practitioners vol. 64 (629), 653-655.
01-12-2014
Ethnicity and the diagnosis gap in liver disease: a population-based study.Alazawi W, Mathur R, Abeysekera K, Hull S, Boomla K, Robson J, Foster GR
Br J Gen Pract vol. 64 (628), e694-e702.
01-11-2014
PTU-138 Population-based Study Of Ethnicity And The Diagnosis Gap In Liver Disease.Alazawi W, Mathur R, Abeysekera K, Hull S, Boomla K, Robson J, Foster G
Gut vol. 63 Suppl 1
01-06-2014
PWE-142 Is Liver Disease Overlooked In Patients With Psoriasis?Ooi J, Chinthapalli S, O'Toole E
Gut vol. 63 Suppl 1
01-06-2014
PTH-080 Risk Profile For Non-alcoholic Fatty Liver Disease (nafld) In A Paediatric Specialist Care Setting.Tai F, Derwa Y, Naik S
Gut vol. 63 Suppl 1, A244-A245.
01-06-2014
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.O'Brien AJ, Fullerton JN, Massey KA, Auld G, Sewell G, James S, Winstanley A, Cordoba J et al.
Nat Med vol. 20 (5), 518-523.
01-05-2014
O154 PROSTAGLANDIN E2 MEDIATES IMMUNOSUPPRESSION IN ACUTELY DECOMPENSATED CIRRHOSISO'Brien A, Fullerton J, Auld G, Newson J, Karra E, Alazawi W, Winstanley A, Juan C et al.
01-04-2014
2013
Humanized Culture of Periosteal Progenitors in Allogeneic Serum Enhances Osteogenic Differentiation and In Vivo Bone FormationRoberts SJ, Owen HC, Tam WL, Solie L, Van Cromphaut SJ, Van den Berghe G, Luyten FP
Stem Cells Translational Medicine, Oxford University Press (Oup) vol. 3 (2), 218-228.
27-12-2013
Maintaining clinical governance when giving telephone adviceAlazawi W, Agarwal K, Aluvihare V
Frontline Gastroenterology, Bmj vol. 4 (4)
06-07-2013
A cross sectional study of colonic diverticulosis in the London Bangladeshi population.Lahiri RP, Abeles A, Burnand KM, Alazawi W, Bhattacharya S, Foster GR, Knowles CH
United European Gastroenterol J vol. 1 (3), 191-197.
01-06-2013
PTH-178 Who Calls the Liver Registrar at King’S?Alazawi W, Agarwal K, Suddle A, Aluvihare V
01-06-2013
OC-041 Enhanced Monocyte Function and Surface TLR Expression Predict Post-Operative Systemic Inflammatory Response Syndrome in Patients Immediately following Major Hepatic and Pancreatic ResectionLahiri R, Wong J, Bhattacharya S, Foster G
Gut, Bmj vol. 62 (Suppl 1)
01-06-2013
Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.Alazawi W, Heath H, Waters JA, Woodfin A, O'Brien AJ, Scarzello AJ, Ma B, Lopez-Otalora Y et al.
Proc Natl Acad Sci U S A vol. 110 (21), 8656-8661.
21-05-2013
319 PATIENTS WITH COMPENSATED CIRRHOSIS HAVE SELECTIVE PARESIS OF FLAGELLIN-INDUCED INNATE IMMUNE RESPONSES DUE TO FAILURES IN ERK SIGNALLINGAlazawi W, Lahiri R, Spyrou A, Giles E, Bashir Z, O'Brien A, Stagg A, Waters J et al.
01-04-2013
The London Bangladeshi community: A population protected against the disease of western civilisationLahiri R, Abeles A, Burnand K, Alazawi W, Foster G, Knowles C
01-01-2013
Increased expression of toll-like receptor (TLR) 4 and TLR5 following complex hepato-pancreatico-biliary (HPB) surgery predicts the development of post-operative systemic inflammatory response syndrome (SIRS)Lahiri R, Wong J, Waters J, Bhattacharya S, Foster G, Alazawi W
01-01-2013
POPULATION BASED STUDY OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) SHOWS DISEASE IS MORE COMMON AMONG BANGLADESHIS IN ETHNICALLY DIVERSE BOROUGHS OF LONDONAlazawi W, Abeysekera K, Boomla K, Foster GR
01-01-2013
IMPLEMENTING EASL & AASLD GUIDELINES FOR HEPATOCELLULAR CARCINOMA SCREENING IS COST-EFFECTIVE IN LONDON'S ETHNICALLY DIVERSE POPULATIONAlazawi W, Abeysekera K, Dearden J, Glynn M, Kallis Y, Kennedy P, Marley R, Foster GR et al.
01-01-2013
RISES IN BOTH WHITE CELL COUNT AND CRP AT DAY 3 PREDICT FAILURE OF TREATMENT WITH METRONIDAZOLE IN C.DIFFICILE INFECTIONJoshi NM, Kok K, Alazawi W, Rampton DS
01-01-2013
2012
Endothelin-1 as a mediator and potential biomarker for interferon induced pulmonary toxicity.George PM, Cunningham ME, Galloway-Phillipps N, Badiger R, Alazawi W, Foster GR, Mitchell JA
Pulm Circ vol. 2 (4), 501-504.
01-10-2012
Pharmacology and therapeutic potential of interferons.George PM, Badiger R, Alazawi W, Foster GR, Mitchell JA
Pharmacol Ther vol. 135 (1), 44-53.
01-07-2012
An orally available, small-molecule interferon inhibits viral replication.Konishi H, Okamoto K, Ohmori Y, Yoshino H, Ohmori H, Ashihara M, Hirata Y, Ohta A et al.
Sci Rep vol. 2
01-01-2012
FLAGELLIN-INDUCED IL-6 PRODUCTION IS SELECTIVELY IMPAIRED IN PATIENTS WITH CIRRHOSISAlazawi W, Spyrou A, Lahiri R, Waters J, Foster GR
Gut vol. 61, A130-A130.
01-01-2012
EVALUATION OF LIVER FIBROSIS IN YOUNG ADULT PATIENTS WITH CHRONIC HEPATITIS B VIRUSPatel C, Gill US, Alazawi W, Shaw P, Alstead E, Kallis Y, Kooner P, Marley R et al.
Gut vol. 61, A133-A133.
01-01-2012
Stat2 loss is associated with enhanced inflammatory cell egress and hepatitis after LPS stimulation despite abolishing inflammatory cytokine production: a novel model of liver inflammationAlazawi W, Waters JA, Heath H, Woodfin A, O'Brien A, Jacobs M, Goldin R, Nourshargh S et al.
01-01-2012
Benchmarking disease activity and progression in Chronic Hepatitis B infected young adultsPatel C, Gill U, Alazawi W, Shaw P, Alstead EM, Kallis Y, Kooner P, Marley R et al.
01-01-2012
2011
P93 NFκB activation by TLR agonists is deficient in macrophages lacking STAT2Alazawi W, Gamero A, Heath H, Smith P, Jacobs M, Waters J, Foster GR
Gut, Bmj vol. 60 (Suppl 2)
01-09-2011
Benefits of knowledge-based interprofessional communication skills training in medical undergraduate education.Buczacki S, Shalhoub J, George PM, Vearncombe LM, Alazawi W
Jrsm Short Rep vol. 2 (8)
01-08-2011
Efficacy of Combination Tenofovir Plus Lamivudine Versus Tenofovir Monotherapy in Patients With Chronic Hepatitis B VirusGlyn FJ, Gill U, Alazawi W, Ross V, Kooner P, Marley R, Foster G, Kennedy PT
01-05-2011
SYSTEMATIC REVIEW: CLOSTRIDIUM DIFFICILE AND IBDGoodhand JR, Alazawi W
01-04-2011
EFFICACY OF COMBINATION TENOFOVIR PLUS LAMIVUDINE VERSUS TENOFOVIR MONOTHERAPY IN PATIENTS WITH CHRONIC HEPATITIS B VIRUSGlyn F, Gill US, Alazawi W, Ross V, Kooner P, Marley R, Foster GR, Kennedy PTF
01-04-2011
Systematic review: Clostridium difficile and inflammatory bowel disease.Goodhand JR, Alazawi W
Aliment Pharmacol Ther vol. 33 (4), 428-441.
01-02-2011
Other Liver VirusesALAZAWI W, Lewis H, Foster GR
Medicine, Elsevier vol. 39 (9), 561-563.
01-01-2011
2010
CAN AN EX VIVO HUMAN LIVER BIOPSY MODEL BE USED TO TEST THE EFFICACY OF DRUGS FOR THE TREATMENT OF HEPATITIS C?Javaid A, Hibbert L, Waters JA, Alazawi W, Foster GR
01-10-2010
Systematic review: outcome of compensated cirrhosis due to chronic hepatitis C infection.Alazawi W, Cunningham M, Dearden J, Foster GR
Aliment Pharmacol Ther vol. 32 (3), 344-355.
01-08-2010
Ready to ExcelAlazawi W
24-06-2010
Combination Therapy for Chronic Hepatitis B Virus Infection: Should we use it ab initio or Sequentially?ALAZAWI W, Foster GR
In Clinical Dilemmas in Viral Liver Disease, Wiley-Blackwell
10-05-2010
NATURAL HISTORY OF COMPENSATED CIRRHOSIS DUE TO CHRONIC HEPATITIS C INFECTION: A SYSTEMATIC REVIEWAlazawi W, Cunningham M, Dearden J, Foster GR
01-04-2010
Mycobacterium mucogenicum causing central line-related sepsis in a home parenteral nutrition patientSimpson AI, Alazawi W, Warwick S, Sheridan E
01-01-2010
Case 36 Syncope in a Patient with Noonan SyndromeAlazawi W
In Cases in Adult Congenital Heart Disease, Elsevier 199-204.
01-01-2010
NATURAL HISTORY OF COMPENSATED CIRRHOSIS DUE TO CHRONIC HEPATITIS C INFECTION: A SYSTEMATIC REVIEWAlazawi W, Cunningham M, Dearden J, Foster GR
01-01-2010
2009
SUBSTITUTION OF ADEFOVIR FOR TENOFOVIR IN PATIENTS WITH CHRONIC HBV RECEIVING COMBINATION THERAPY WHO HAVE INCOMPLETE CONTROL OR VIROLOGICAL BREAKTHROUGH - IS IT WORTH-WHILE?Alazawi W, Cottle R, Ross V, Ushiro-Lumb I, Alstead EM, Glynn M, Marley R, Foster GR
01-10-2009
Syncope in a Patient with Noonan SyndromeALAZAWI W
In Cases in Adult Congenital Heart Disease, Churchill Livingstone
10-07-2009
STAT2 IS A MAJOR DETERMINANT OF HEPATIC INFLAMMATION AND MORTALITY IN A KNOCKOUT MOUSE MODEL OF PERITONEAL INFLAMMATIONAlazawi W, Gamero A, Waters J, Jacobs M, Foster G
01-01-2009
2008
Advances in the diagnosis and treatment of hepatitis B.Alazawi W, Foster GR
Curr Opin Infect Dis vol. 21 (5), 508-515.
01-10-2008
2006
Interferon-β treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrantsHerdman MT, Pett MR, Roberts I, Alazawi WOF, Teschendorff AE
Carcinogenesis vol. 27 (11), 2341-2353.
01-01-2006
2004
Genomic imbalances in 70 snap-frozen cervical squamous intraepithelial lesions: associations with lesion grade, state of the HPV16 E2 gene and clinical outcome.Alazawi W, Pett M, Strauss S, Moseley R, Gray J, Coleman N
Br J Cancer vol. 91 (12), 2063-2070.
13-12-2004
In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line.Morgan C, Alazawi W, Sirieix P, Freeman T
Am J Gastroenterol vol. 99 (2), 218-224.
01-02-2004
Acquisition of High-Level Chromosomal Instability Is Associated with Integration of Human Papillomavirus Type 16 in Cervical KeratinocytesPett MR, ALAZAWI W, Roberts I, Dowen S, Smith DI, Coleman N
Cancer Research, American Association For Cancer Research vol. 64 (4), 1359-1368.
01-01-2004
2003
Primary or secondary malignancy? Fingerprint evidence.Alazawi W, Gonzalez M, Arends M, Coleman N
Clin Oncol (R Coll Radiol) vol. 15 (7), 408-411.
01-10-2003
Acquisition of high-level genomic instability is associated with integration of HPV16 in cervical keratinocytesPett MR, Alazawi W, Roberts I, Stanley MA
01-09-2003
Immediate and early gene response to in vitro acid exposure in a Barrett's adenocarcinoma cell lineMorgan C, Alazawi W, Coleman N, Fitzgerald R
01-04-2003
Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervixALAZAWI W, Morris LS, Garrod DR
Virchows Archiv: The European Journal of Pathology, Springer vol. 443 (1), 51-56.
01-01-2003
2002
Changes in cervical keratinocyte gene expression associated with integration of human papillomavirus 16.Alazawi W, Pett M, Arch B, Scott L, Freeman T, Stanley MA
Cancer Res vol. 62 (23), 6959-6965.
01-12-2002
Changes in host cell genome and transcriptome associated with integration of HPV 16 in cervical keratinocytesAlazawi W, Pett M, Stanley M, Coleman N
J Pathol vol. 198, 8A-8A.
01-09-2002
Mapping vascular plasticity in liver fibrogenesis identifies novel fibrosis-associated endothelial cells in early-stage liver diseaseGkantsinikoudi C, Dignam JP, Kumar R, Jokl E, Li W, Samus M, Landi S, Athwal VS et al.
In Biorxiv
adam17Alazawi W
Frontiers in Immunology, Frontiers Media
Stat2 loss disrupts damage signalling and is protective in acute pancreatitisHeath H, Britton G, Kudo H, Renney G, Ward M, Hutchins R, Foster GR, Goldin R et al.
In Biorxiv
Grants
Grants of specific relevance to Predictive in vitro Models
Determinants of MASLD in Lean and Obese Individuals: A Precision Healthcare Analysis Using UK BiobanWilliam Alazawi, Kamil Demircan, Claudia Langenberg and Alice Williamson
£7,000 Barts and the London Charity
30-09-2025 - 29-09-2026
HARP fellowship - Catherine HsuWilliam Alazawi
£387,368 MCSBHT Medical College of St Bartholomew's Hospital Trust
01-09-2025 - 30-09-2028
MASLD Partnership Grant - UK-TaiwanWilliam Alazawi and Huei-Tyng Huang
£12,000 Royal Society
31-03-2025 - 30-03-2027
Atypical Chemokine Receptors orchestrate changes in vascular patterning during fibrotic liver disease via Endothelial-to-Mesenchymal Transition.Neil Dufton, William Alazawi and Antal Rot
£610,383 Medical Research Council
08-05-2024 - 07-05-2027
Fructose is a metabolic and inflammatory pathogenic factor in non-alcoholic steatohepatitisWilliam Alazawi, Dunja Aksentijevic, Katiuscia Bianchi, Li Chan and Sian Henson
£419,496 Barts and the London Charity
01-04-2023 - 31-03-2027
Epidemiology and Natural History of NAFLD in large primary care cohortsWilliam Alazawi
£677,150 Merck
01-03-2023 - 31-07-2026
The prevalence of GAD65, IA-2, ZnT8 and C-peptide levels in a LADA cohortRichard Leslie and William Alazawi
£25,310 Phadia GmbH (part of Thermo Fisher Scientific)
01-01-2023 - 31-12-2026
Health advances in underrepresented populations and diseases (HARP)Marta Korbonits, Edel O'Toole and William Alazawi
£7,108,704 Wellcome Trust
01-07-2022 - 30-06-2029
Multimodal profiling of inflammatory and immune cells to determine stage and treatment response in non-alcoholic steatohepatitis and type II diabetesWilliam Alazawi, Louisa James and Federica Marelli-Berg
£771,903 MRC Medical Research Council
05-07-2021 - 31-03-2025
Covid Research Hepatology LaboratoryWilliam Alazawi
£92,814 BH NHS Barts Health NHS
01-11-2020 - 31-10-2023
The adipokine BAFF is a therapeutic target in non-alcoholic steatohepatitisWilliam Alazawi
£421,164 GlaxoSmithKline UK Ltd
01-11-2020 - 31-03-2025
Investigating the therapeutic potential of disease-associated endothelial cells in liver diseaseNeil Dufton and William Alazawi
£35,000 Barts and the London Charity
02-03-2020 - 30-04-2022
Feasibility and acceptability of a primary care liver fibrosis testing pathway in diabetesWilliam Alazawi
£393,986 Gilead Sciences Ltd
01-11-2019 - 31-12-2024
Investigating stat2 as a therapeutic target in Non-alcoholic fatty liver disease (NAFLD) using individualised hepatocyte like cells derived from human induced pluripotent stem cellsWilliam Alazawi
£4,000 Barts and the London Charity
01-02-2019 - 31-01-2020
QMUL will test the UCB antibodies to try and establish if any of the antibodies will stain for extracellular TG2William Alazawi
£10,000 UCB Pharma SPRL
21-01-2019 - 20-04-2019
Investigating the impact of age, ethnicity and genetic polymorphisms on hepatocyte injury in non-alcoholic fattyliver disease using individualised hepatocyte-like cells derived from hidden induced pluripotent stem cellsWilliam Alazawi
£4,000 Barts and the London Charity
01-09-2018 - 31-08-2019
The pivotal role of TLR5 in non-alcoholic fatty liver diseaseWilliam Alazawi
£466,119 Barts and the London Charity
16-04-2018 - 30-06-2023
The peripheral immune response to major surgeryWilliam Alazawi
£4,000 Barts and the London Charity
01-01-2018 - 30-06-2018
Stat2 is a key mediator in acute pancreatitisWilliam Alazawi
£20,000 Physicians, Assoc.of ASSOCIATION OF PHYSICIANS
01-08-2017 - 31-07-2020
Stat2 is a therapeutic target in liver inflammationWilliam Alazawi
£523,042 MRC Medical Research Council
01-03-2016 - 28-02-2019

