Dr Maria Fragiadaki
Senior Lecturer
Translational Medicine and Therapeutics, The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Kidney, Kidney-on-a-Chip, polycystic kidney disease, ADPKD, renal toxicity, drug screening
Interests
My lab is intrestrd in developing a kidney-on-chip (KoC) model for drug testing using patient-derived cells from Autosomal Dominant Polycystic Kidney Disease (ADPKD). This approach could significantly advance our understanding of ADPKD and accelerate drug discovery for this genetic disorder. By using patient-derived cells, you can create a more accurate representation of the disease microenvironment, allowing for better prediction of drug efficacy and toxicity. This model could be particularly valuable for testing novel therapies and for identifying potential biomarkers for ADPKD progression and treatment response.Publications
2025
ANKHD1 promotes pathogenic proliferation in Autosomal Dominant Polycystic Kidney Disease via the Cyclin D1/CDK4 pathwayTerzenidou M-E, Patera F, Macleod FM, Ong ACM, Fragiadaki M
Journal of Translational Medicine, Springer Nature vol. 23 (1)
02-06-2025
2024
Shear stress is uncoupled from atheroprotective KLK10 in atherosclerotic plaquesZhou Z, Korteland S-A, Tardajos-Ayllon B, Wu J, Chambers E, Weninck J, Simons M, Dunning M et al.
Atherosclerosis, Elsevier vol. 398
04-10-2024
Targeting Growth Hormone/JAK2 Signaling as a Novel Therapy for Polycystic Kidney Disease TreatmentMacleod F, Fragiadaki M
Journal of The American Society of Nephrology, Wolters Kluwer vol. 35 (10S)
01-10-2024
Role of Ankyrin Repeat and Single KH Domain 1 in Autosomal Dominant Polycystic Kidney Disease Pathogenesis and CyclinD1/CDK4-Induced ProliferationTerzenidou M-E, Macleod F, Fragiadaki M
Journal of The American Society of Nephrology, Wolters Kluwer vol. 35 (10S)
01-10-2024
Influence of PKD1-Mediated Apoptosis on Proliferation and Autophagy in Human Embryonic Kidney CellsAhmed E, Fragiadaki M
Journal of The American Society of Nephrology, Wolters Kluwer vol. 35 (10S)
01-10-2024
ANKHD1 Has a Cytoprotective Role in Stressed Kidney CellsMullenger J, Zeidler M, Fragiadaki M
Journal of The American Society of Nephrology, Wolters Kluwer vol. 35 (10S)
01-10-2024
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid UptakePirri D, Tian S, Tardajos-Ayllon B, Irving SE, Donati F, Allen SP, Mammoto T, Vilahur G et al.
Circulation Research, Wolters Kluwer vol. 135 (8), 822-837.
05-09-2024
2023
Evaluating the Molecular Properties and Function of ANKHD1, and Its Role in CancerMullenger JL, Zeidler MP, Fragiadaki M
International Journal of Molecular Sciences, Mdpi vol. 24 (16)
16-08-2023
BS2 Flow-regulated EPAS1 limits atherosclerosis via metabolic control of endothelial proliferationTian S, Pirri D, Tardajos-Ayllon B, Fragiadaki M, Evans PC
Basic Science.
01-06-2023
2022
JAG1-NOTCH4 mechanosensing drives atherosclerosisSouilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 8 (35)
31-08-2022
BS21 Endothelial cell profile in responses to high shear stress is different in healthy arteries and plaquesZhou Z, Wu J, Wentzel J, Schenkel T, Diagbouga M, Fragiadaki M, Simons M, Evans P
Basic science.
01-06-2022
Lessons from microRNA biology: Top key cellular drivers of Autosomal Dominant Polycystic Kidney DiseaseFragiadaki M
Biochimica Et Biophysica Acta (Bba) - Molecular Basis of Disease, Elsevier vol. 1868 (5)
09-02-2022
2021
BS30 Light sheet imaging to analyse the spatial distribution of proteins in atherosclerotic plaquesZhou Z, Van-Hateren N, Francis S, Fragiadaki M, Evans P
Basic science.
01-06-2021
2020
The Controversial Role of Fibrosis in Autosomal Dominant Polycystic Kidney DiseaseFragiadaki M, Macleod FM, Ong ACM
International Journal of Molecular Sciences, Mdpi vol. 21 (23)
25-11-2020
Shear stress: the dark energy of atherosclerotic plaquesEvans PC, Fragiadaki M, Morris PD, Serbanovic-Canic J
Cardiovascular Research, Oxford University Press (Oup) vol. 117 (8), 1811-1813.
04-11-2020
Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?Pirri D, Fragiadaki M, Evans PC
Bioscience Reports, Portland Press vol. 40 (8)
20-08-2020
Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular ScienceEvans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 116 (14), 2177-2184.
04-08-2020
2019
Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sitesSouilhol C, Gauci I, Feng S, Ayllon BT, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 116 (7), 1300-1310.
29-08-2019
Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genesSouilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC
Nature Reviews Cardiology, Springer Nature vol. 17 (1), 52-63.
31-07-2019
β1 integrin is a sensor of blood flow directionXanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR et al.
Journal of Cell Science, The Company of Biologists vol. 132 (11)
01-06-2019
BS28 Endothelial STAT5A is enriched at atheroprone regions of the aorta and drives inflammation in response to low shear stressRoddie H, Fragiadaki M, Evans P
Basic Science.
01-05-2019
Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesisPatera F, Cudzich-Madry A, Huang Z, Fragiadaki M
Scientific Reports, Springer Nature vol. 9 (1)
14-03-2019
2018
The Bernard and Joan Marshall Early Career Investigators and Distinguished Investigator Award 2018Fragiadaki M, Evans PC
Cardiovascular Drugs and Therapy, Springer Nature vol. 33 (2), 203-205.
14-12-2018
A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stabilityFisher KH, Fragiadaki M, Pugazhendhi D, Bausek N, Arredondo MA, Thomas SJ, Brown S, Zeidler MP
Journal of Cell Science, The Company of Biologists vol. 131 (13)
01-07-2018
Ankyrin repeat and single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAsFragiadaki M, Zeidler MP
Journal of Biological Chemistry, Elsevier vol. 293 (25), 9570-9579.
25-04-2018
2017
Response by Feng et al to Letter Regarding Article, “Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites”Feng S, Fragiadaki M, Souilhol C, Ridger V, Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 37 (12), e199-e200.
01-12-2017
Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone SitesFeng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D et al.
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 37 (11), 2087-2101.
07-09-2017
STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney diseaseFragiadaki M, Lannoy M, Themanns M, Maurer B, Leonhard WN, Peters DJM, Moriggl R, Ong ACM
Kidney International, Elsevier vol. 91 (3), 575-586.
16-01-2017
2016
Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sectionsIkeda T, Fragiadaki M, Shi-wen X, Ponticos M, Khan K, Denton C, Garcia P, Bou-Gharios G et al.
Data in Brief, Elsevier vol. 8, 1377-1380.
10-08-2016
Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblastsIkeda T, Fragiadaki M, Shi-wen X, Ponticos M, Khan K, Denton C, Garcia P, Bou-Gharios G et al.
Biochemistry and Biophysics Reports, Elsevier vol. 7, 246-252.
02-07-2016
2013
Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for DeubiquitinationLuong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M et al.
Circulation Research, Wolters Kluwer vol. 112 (12), 1583-1591.
05-04-2013
2012
Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor Implications for Diabetic NephropathyFragiadaki M, Hill N, Hewitt R, Bou-Gharios G, Cook T, Tam FW, Domin J, Mason RM
Diabetes, American Diabetes Association vol. 61 (9), 2280-2288.
17-08-2012
2011
Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivoFragiadaki M, Witherden AS, Kaneko T, Sonnylal S, Pusey CD, Bou-Gharios G, Mason RM
Matrix Biology, Elsevier vol. 30 (7-8), 396-403.
12-08-2011
Epithelial‐mesenchymal transition in renal fibrosis – evidence for and againstFragiadaki M, Mason RM
International Journal of Experimental Pathology, Wiley vol. 92 (3), 143-150.
06-05-2011
High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1Fragiadaki M, Ikeda T, Witherden A, Mason RM, Abraham D, Bou-Gharios G
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 22 (11), 1836-1844.
06-04-2011
JAG1-NOTCH4 Mechanosensing Drives AtherosclerosisSouilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ et al.
In Biorxiv
Ankhd1 enhances polycystic kidney disease development via promoting proliferation and fibrosisPatera F, Hautbergue GM, Wilson P, Evans PC, Ong AC, Fragiadaki M
In Biorxiv
β1 integrin is a sensor of blood flow directionXanthis I, Souilhol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR et al.
In Biorxiv
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid UptakePirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen SP, Mammoto T, Vilahur G et al.
In Biorxiv
Grants
Grants of specific relevance to Predictive in vitro Models
Generate and test a cutting-edge Organ-on-a-Chip technology for Polycystic Kidney DiseaseMaria Fragiadaki and Thomas Iskratsch
£123,105 Vertex Pharmaceuticals (Europe) Limited
01-10-2025 - 30-09-2029
Mechanisms driving Autosomal Dominant Polycystic Kidney Disease; The novel role of the RNA-binding protein ANKHD1Maria Fragiadaki
£566,085 Medical Research Council
01-02-2023 - 01-04-2026