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Musculoskeletal Models

Queen Mary University of London holds two chairs of Versus Arthritis, prestigious awards in musculoskeletal research and is intimately linked to the Barts Health NHS Trust Musculoskeletal Clinical Service connecting the bench to the clinic. QMUL have also obtained a major investment from Bart’s Charity for the establishment of a new Centre of Excellence for Academic Trauma and Orthopaedic Surgery.

MSK research at QMUL is interdisciplinary combining biology, engineering and materials science. Key research areas include tissue regeneration (Prof. Dell Accio), musculoskeletal tissue mechanics and models of pathology (Prof. Screen), mechanobiology (Prof. Knight) as well as 3D tissue constructs to mimic the cellular microenvironment of cartilage (Dr. Chowdhury). Utilising human joint models is highly advantageous to identify novel therapeutics that will halt inflammation as well as repair and regenerate damaged tissues (Dr. Norling, Prof. Dalli, Prof. Dell’Accio, Prof. Knight).  Some of the state-of-the art projects include 3D bioprinting human pluripotent stem cell-derived skeletal muscle constructs for disease modelling (Dr Lin/Dr. Connelly),  Organ-on-a-chip models for safety testing of regenerative medicine products (Prof. Screen, Prof. Knight), development of mechanically enhanced osteoinductive synthetic bone graft substitutes (Dr. Hing) as well as nano- and microscale mechanics of impact resistant biocomposites for bone and cartilage using pioneering technologies (Dr. Gupta).