Publications
The following journal papers published by the members of the CPM, specifically relate to the development and/or use of predictive in vitro models.
- Modelling the Impact of Patient-Specific Fibrosis and Anatomy on Atrial Fibrillation Triggered by Pulmonary Vein Ectopy
Nwanna C, Bevis L, Biniam Misghina S, Vidal Horrach C, Ahmed Jaffery O, Ehnesh M, Iskratsch T, Tinker A et al.
2025 Computing in Cardiology Conference (CinC).
12-12-2025 - Development and characterization of an on-chip glioma outgrowth model
Daoud JPA, Collisson AE, Asaid D, do Couto Lopes EC, Paraskevopoulos D, Chapman CAR
In Vitro Models, Springer Nature, 1-13.
08-12-2025 - 256 Altered nuclear architecture in epidermolysis bullosa simplex
Lay E, Guo Y, Gautrot J, Kelsell D, Connelly J
Journal of Investigative Dermatology, Elsevier vol. 145 (12)
01-12-2025 - P7 Development of a biochip for dissection of multivalent atherosclerosis signalling
Smyth R, Palma M, Iskratsch T
Poster.
01-12-2025 - P10 Interstitial Flow-Induced Phenotypic Switching of Vascular Smooth Muscle Cells: Mechanistic Insights and Vascular Implications
Lakshminaraasimulu NK, Iskratsch T
Poster.
01-12-2025 - Artificial cells evidence apical compressive forces building up during neuroepithelial organoid early development
Kanso H, Di Cio S, Rose R, Palacios I, Gautrot JE
Biomaterials, Elsevier vol. 328
24-11-2025 - Multi-omics qualification of an organ-on-a-chip model of osteolytic bone metastasis
Castro NM, Nolan J, Maniati E, Agrawal A, Gauthier V, Pearce OMT, Verbruggen SW, Knight MM
Acta Biomaterialia, Elsevier vol. 209, 362-374.
13-11-2025 - Heterogeneity in responses to ribosome-targeting antibiotics mediated by bacterial RNA repair
Hindley HJ, Gong Z, Moradian S, Giuliano MG, Sapelkin A, Kotta-Loizou I, Buck M, Engl C et al.
Nature Communications, Springer Nature vol. 16 (1)
11-11-2025 - The Transcription Factor TWIST‐Related Protein 1 in Atherosclerosis
Li X, Zhang C, Wu D, Xu S, Feng B, Evans PC
, Wiley vol. 1 (1)
06-11-2025 - HUMAN JOINT-ON-A-CHIP: MODEL DEVELOPMENT AND APPLICATION TO STUDY PATIENT-SPECIFIC CROSSTALK
Hopkins T, Thompson CL, Terrazas DA, Wright KT, Screen HR, Knight MM
Orthopaedic Proceedings, British Editorial Society of Bone & Joint Surgery vol. 107-B (SUPP_9), 33-33.
22-10-2025 - Mechanisms of Osteoblast‐Like Cells and Bacterial Responses to Copper in Titanium‐Copper Alloys
Khalid J, Stephen AS, Rawlinson SCF, Allaker RP
Journal of Biomedical Materials Research Part A, Wiley vol. 113 (10)
30-09-2025 - Biomimetic organo-hydrogels reveal the adipose tissue local mechanical anisotropy regulates ovarian cancer invasion
Gonzalez-Molina J, Nabili P, Marciano D, Abdelnabi S, Gultekin O, Rasul MF, Zhang Y, Nadal C et al.
Nature Communications, Springer Nature vol. 16 (1)
29-09-2025 - Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast
Kumar J, Ng K, Rallis C
Communications Biology, Springer Nature vol. 8 (1)
29-09-2025 - Development of an In Vitro Bone Metastasis Model Mimicking Cellular Crosstalk in the Bone Microenvironment
Villette C, Champion A
Congress of the European Society Of Biomaterials Turin 7 Sep 2025 - 11 Sep 2025.
07-09-2025 - Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling
Marhuenda E, Xanthis I, Smith PO, Prakash A, Kallem T, Pandey P, Wilson DGS, Azad A et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 11 (36)
05-09-2025 - Biomimetic artificial bone marrow niches for the scale up of hematopoietic stem and progenitor cells
Bosch-Fortea M, Marciano D, Gautrot JE
Biomaterials, Elsevier vol. 325
08-08-2025 - A CD24+CD271+ melanoma cancer stem cell possesses hybrid characteristics of its single marker counterparts and promotes invasion and therapeutic resistance
Knowles O, Doldan P, Hillier-Richardson I, Lunetto S, Lunt S, Youssef G, Gammon L, Mackenzie IC et al.
Bmc Biology, Springer Nature vol. 23 (1)
04-08-2025 - Understanding the sources of performance in deep drug response models reveals insights and improvements
Branson N, Cutillas PR, Bessant C
Bioinformatics, Oxford University Press (Oup) vol. 41 (Supplement_1), i142-i149.
01-07-2025 - Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast
Alao J-P, Kumar J, Stamataki D, Rallis C
Microbial Cell, Shared Science Publishers Og vol. 12 (1)
24-06-2025 - Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP
Hou Y, Screen HRC, Knight MM
Apl Bioengineering, Aip Publishing vol. 9 (2)
01-06-2025 - Impact of galanin receptors 2 and 3 double-knockout on neuroinflammation and functional recovery following traumatic brain injury
Brunner SM, Gaisbauer S, Pallier PN, Yip PK, Ramspacher A, Leitner J, Sternberg F, Erhardt-Kreutzer C et al.
Peptides, Elsevier vol. 191
22-05-2025 - A Role for High Mobility Group Box 1 (HMGB1) Release in the Pathogenesis of Gastroesophageal Reflux Disease
Leech T, Kelsell D, Blaydon D, Woodland P, Peiris M
Neurogastroenterology & Motility, Wiley vol. 37 (11)
20-05-2025 - Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems
Hopkins T, Midha S, Grossemy S, Screen HRC, Wann AKT, Knight MM
Journal of Tissue Engineering, Sage Publications vol. 16
18-04-2025 - “Spin‐Rinse and Repeat”: Facile Processing to Improve Cytocompatibility of Poly(3,4‐Ethyelenedioxythiophene): Polystyrene Sulfonate Composites for Bioelectronics
Killilea J, Lee A, Cuttaz EA, Miceli GC, Suquia LL, Goding JA, Chapman CAR, Green RA
Advanced Nanobiomed Research, Wiley vol. 5 (5)
13-04-2025 - Engineered human myogenic cells in hydrogels generate innervated vascularized myofibers within dystrophic mouse muscle on long-term engraftment
Kowala A, Boot J, Meng J, Mein CA, Pourquié O, Connelly JT, Morgan JE, Lin Y-Y
Cell Reports Medicine, Elsevier Bv, 102019-102019.
07-03-2025 - Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma
Mariniello K, Pittaway JFH, Altieri B, Borges KS, Hadjidemetriou I, Ribeiro C, Ruiz‐Babot G, Tourigny DS et al.
Cancer Communications, American Association For The Advancement of Science (Aaas) vol. 45 (6), 663-668.
04-03-2025 - The p3 peptides (Aβ17-40/42) rapidly form amyloid fibrils that cross-seed with full-length Aβ
Tian Y, Torres-Flores AP, Shang Q, Zhang H, Khursheed A
Nature Communications, Springer Nature vol. 16 (1)
27-02-2025 - Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis
Hollingworth BYA, Pallier PN, Jenkins SI
Brain Sciences, Mdpi vol. 15 (3)
26-02-2025 - Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways
Ayllon BT, Bowden N, Souilhol C, Darwish H, Tian S, Duckworth C, Pritchard DM, Xu S et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 121 (5), 748-759.
21-02-2025 - Transient flow-induced deformation of cancer cells in microchannels: a general computational model and experiments
Lu R, Li J, Guo Z, Wang Z, Feng JJ, Sui Y
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 24 (2), 489-506.
02-02-2025 - Automated pericardium segmentation and epicardial adipose tissue quantification from computed tomography images
Wang Y, Wang A, Wang L, Tan W, Xu L, Wang J, Sun Y, Yang B
Biomedical Signal Processing and Control, Elsevier vol. 100
01-02-2025 - Semi-mechanistic efficacy model for PARP + ATR inhibitors—application to rucaparib and talazoparib in combination with gartisertib in breast cancer PDXs
Villette CC, Dupuy N, Brightman FA, Zimmermann A, Lignet F, Zenke FT, Terranova N, Bolleddula J et al.
British Journal of Cancer, Springer Nature vol. 132 (5), 481-491.
28-01-2025 - Replicating Dynamic Immune Responses at Single‐Cell Resolution within a Microfluidic Human Skin Equivalent
Hindle SA, Brook HB, Chrysanthou A, Chambers ES, Caley MP, Connelly JT
Advanced Science, Wiley vol. 12 (10)
21-01-2025