Prof David Lee
Professor of Cell & Tissue Engineering
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Mechanobiology, Stem cell biology, Circadian biology, Musculoskeletal, Energy metabolism, Cartilage
Publications
Publications of specific relevance to Predictive in vitro Models2022
Heywood HK, Thorpe SD, Jeropoulos RM, Caton PW and Lee DA (2022). Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment. Frontiers Media Frontiers in Bioengineering and Biotechnology vol. 10, 10.3389/fbioe.2022.971932Heywood HK, Gardner L, Knight MM and Lee DA (2022). Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems. Springer Nature In Vitro Models 1-8. 10.1007/s44164-022-00032-xBrookes O, Thorpe SD, Evans OR, Keeling MC and Lee DA (2022). Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells. Frontiers Frontiers in Cell and Developmental Biology vol. 10, 10.3389/fcell.2022.8588842021
Lachowski D, Cortes E, Matellan C, Rice A, Lee DA, Thorpe SD and del Río Hernández AE (2021). G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization. Frontiers Media Frontiers in Cell and Developmental Biology vol. 8, 592628-592628. 10.3389/fcell.2020.5926282020
Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H, Lee DA, Plodinec M and Del Río Hernández AE (2020). GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA. Mdpi Ag Cancers vol. 12, (2) 10.3390/cancers12020289Thorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D, Hytonen V and del Río Hernández A (2020). Syndecan-4 tunes cell mechanics by activating
the kindlin-integrin-RhoA pathway. Nature Research Nature Materials 10.1038/s41563-019-0567-12018
Cortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L, Rombouts K and del Río Hernández AE (2018). Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Springer Nature [Academic Journals On Nature.Com] Oncogene 10.1038/s41388-018-0631-3Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada‐Hatakeyama M, Varjosalo MT and Hernández AER (2018). Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival. Springer Nature Embo Reports vol. 20, (1) 10.15252/embr.201846557Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA and Hernández AER (2018). GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. Springer Nature Embo Reports vol. 20, (1) 10.15252/embr.201846556Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA, Wang H, Pinato DJ and del Rio Hernández AE (2018). RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells. Wiley Hepatology 10.1002/hep.301932017
Elyasigomari V, Lee DA, Screen HRC and SHAHEED MH (2017). Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification. Journal of Biomedical Informatics vol. 67, (2017) 11-20. 10.1016/j.jbi.2017.01.016THORPE SD and Lee DA (2017). Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity. Taylor & Francis Nucleus vol. 8, (3) 287-300. 10.1080/19491034.2017.12859882016
Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA and Mauck RL (2016). Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. Elife Sciences Publications Ltd Elife vol. 5, 10.7554/eLife.18207Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT (2016). Oxygen tension modulates the effects of TNFα in compressed chondrocytes. Inflamm Res 10.1007/s00011-016-0991-5Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL and Mauck RL (2016). Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophysical Journal vol. 111, (4) 864-874. 10.1016/j.bpj.2016.07.006Heywood HK and Lee DA (2016). Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen. Journal of Tissue Engineering and Regenerative Medicine vol. 11, (8) 2286-2294. 10.1002/term.2126Sliogeryte K, Botto L, Lee DA and Knight MM (2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Elsevier Osteoarthritis and Cartilage vol. 24, (5) 912-920. 10.1016/j.joca.2015.12.007Lee D (2016). States rights and Australia’s adoption of the statute of Westminster, 1931–1942. Taylor & Francis History Australia vol. 13, (2) 258-274. 10.1080/14490854.2016.1186001Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT (2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. Elsevier Journal of Investigative Dermatology vol. 136, (1) 74-83. 10.1038/jid.2015.352Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT (2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol vol. 136, (1) 74-83. 10.1038/JID.2015.3522015
Heo S-J, Thorpe SD, Driscoll TP, Duncan RL, Lee DA and Mauck RL (2015). Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Springer Nature Scientific Reports vol. 5, (1) 10.1038/srep16895CHEN J, BADER DL, LEE DA and KNIGHT MM (2015). FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD. World Scientific Publishing Journal of Mechanics in Medicine and Biology vol. 15, (05) 10.1142/s02195194155007732014
Sliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM (2014). Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. Springer Nature Scientific Reports vol. 4, (1) 10.1038/srep07307Irianto J, Lee DA and Knight MM (2014). Quantification of chromatin condensation level by image processing. Med Eng Phys vol. 36, (3) 412-417. 10.1016/j.medengphy.2013.09.006Heywood HK, Nalesso G, Lee DA and Dell'accio F (2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access vol. 3, (1) 9-18. 10.1089/biores.2013.00512013
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA (2013). Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J vol. 104, (4) 759-769. 10.1016/j.bpj.2013.01.006Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA (2013). Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells. Tissue Engineering Part C-Methods vol. 19, (1) 10.1089/ten.tec.2011.0734Lee D (2013). Reluctant relaxation. Taylor & Francis History Australia vol. 10, (3) 149-170. 10.1080/14490854.2013.116684852012
Sillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM and Orengo CA (2012). New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. Oxford University Press (Oup) Nucleic Acids Research vol. 41, (D1) d490-d498. 10.1093/nar/gks1211Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM (2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophys J vol. 103, (6) 1188-1197. 10.1016/j.bpj.2012.07.054Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM (2012). Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study. J Mech Behav Biomed Mater vol. 11, 72-81. 10.1016/j.jmbbm.2011.06.015Branford OA, Lee DA, Bader DL and Grobbelaar AO (2012). The mechanics of flexor tendon adhesions. Journal of Hand Surgery: European Volume vol. 37, (6) 555-563. 10.1177/1753193411432675Branford OA, Lee DA, Rolfe KJ and Grobbelaar AO (2012). The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin. Journal of Hand Surgery: European Volume vol. 37, (6) 564-572. 10.1177/1753193411428994Lee D, Smallbone K, Dunn WB, Murabito E, Winder CL, Kell DB, Mendes P and Swainston N (2012). Improving metabolic flux predictions using absolute gene expression data. Springer Nature Bmc Systems Biology vol. 6, (1) 10.1186/1752-0509-6-73Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology vol. 11, (3-4) 439-447. 10.1007/s10237-011-0323-1Lee D (2012). Stanley Melbourne Bruce in London, 1938–41. Taylor & Francis The Journal of Imperial & Commonwealth History vol. 40, (1) 45-65. 10.1080/03086534.2012.656489Gutowski IA, Lee D, de Bruyn JR and Frisken BJ (2012). Scaling and mesostructure of Carbopol dispersions. Springer Nature Rheologica Acta vol. 51, (5) 441-450. 10.1007/s00397-011-0614-6Hosny NA, Lee DA and Knight MM (2012). Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. J Biomed Opt vol. 17, (1) 10.1117/1.JBO.17.1.016007Martins RP, Finan JD, Guilak F and Lee DA (2012). Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng vol. 14, 431-455. 10.1146/annurev-bioeng-071910-1246382011
Jaimes N, Scope A, Welzel J, Wang KX, Lee DA, Siegel DM and Marghoob AA (2011). White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics. Wolters Kluwer Dermatologic Surgery vol. 38, (1) 128-132. 10.1111/j.1524-4725.2011.02198.xPattappa G, Heywood HK, de Bruijn JD and Lee DA (2011). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol vol. 226, (10) 2562-2570. 10.1002/jcp.22605Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc Inst Mech Eng H vol. 225, (8) 821-830. 10.1177/0954411911406340Moses SE, Osborne W, Valappil M, Collin M, Lee D, Waugh S, Jackson G, Parry CM and Crowley B (2011). Extensive oral herpes simplex virus type 1 infection in a haematopoietic stem cell transplant recipient not responding to aciclovir. Elsevier Journal of Clinical Virology vol. 52, (2) 67-69. 10.1016/j.jcv.2011.05.015Lee D, Gutowski IA, Bailey AE, Rubatat L, de Bruyn JR and Frisken BJ (2011). Investigating the microstructure of a yield-stress fluid by light scattering. American Physical Society (Aps) Physical Review E vol. 83, (3) 10.1103/physreve.83.031401Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2011). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology 1-9. 10.1007/s10237-011-0323-1Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. P I Mech Eng H vol. 225, (H8) 821-830. 10.1177/0954411911406340Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA and Stark JPW (2011). Electrospray deposited fibronectin retains the ability to promote cell adhesion. Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B, (1) 110-118. 10.1002/jbm.b.31745Lee DA, Knight MM, Campbell JJ and Bader DL (2011). Stem cell mechanobiology. J Cell Biochem vol. 112, (1) 1-9. 10.1002/jcb.22758Lee D, de Beer TA, Laskowski RA, Thornton JM and Orengo CA (2011). 1,000 structures and more from the MCSG. Springer Nature Bmc Molecular and Cell Biology vol. 11, (1) 10.1186/1472-6807-11-2Lee DA and Siegel DM (2011). Novel devices for diagnosis and treatment. Journal of Drugs in Dermatology vol. 10, (1) 21-22. Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT (2011). Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol vol. 695, 77-97. 10.1007/978-1-60761-984-0_62010
Pattappa G, Heywood HK, de Bruijn JD and Lee DA (2010). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol 10.1002/jcp.22605Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL and Lee DA (2010). Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research vol. 51, (6) 434-444. 10.3109/03008201003597056Heywood HK, Knight MM and Lee DA (2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology vol. 223, (3) 630-639. 10.1002/jcp.22061Lee D (2010). Giving something back. Twist (22) 28-30. Ye S, Maeda E, Knight M, Lee D, Bader D and Wang W (2010). A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles. Faseb Journal vol. 24, 10.1096/fasebj.24.1_supplement.975.9Heywood HK and Lee DA (2010). Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol vol. 222, (1) 248-253. 10.1002/jcp.219462009
Maeda E, Shelton JC, Bader DL and Lee DA (2009). Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering vol. 4, (4) 510-517. 10.1299/jbse.4.510Lee DA, Rentzsch R and Orengo C (2009). GeMMA: functional subfamily classification within superfamilies of predicted protein structural domains. Oxford University Press (Oup) Nucleic Acids Research vol. 38, (3) 720-737. 10.1093/nar/gkp1049Pattappa G, Jegard NC, Lee DA and de Bruijn JD (2009). The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cells. European Cells and Materials vol. 18, (SUPPL. 1) Campbell JJ, Maeda E, Ye SJ, Wang W and Lee DA (2009). Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system. European Cells and Materials vol. 18, (SUPPL. 2) Pattappa G, Jegard NC, de Bruijn JD and Lee DA (2009). The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cells. European Cells and Materials vol. 18, (SUPPL. 2) Maeda E, Shelton JC, Bader DL and Lee DA (2009). Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology vol. 106, (2) 506-512. 10.1152/japplphysiol.90981.2008Eniwumide JO, Lee DA and Bader DL (2009). The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties. Biorheology vol. 46, (5) 417-437. 10.3233/BIR-2009-0552Berry CC, Shelton JC and Lee DA (2009). Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med vol. 3, (1) 43-53. 10.1002/term.1332008
Pattappa G, A. Lee D and De Bruijn JD (2008). Metabolic characteristics of human mesenchymal stem cells expanded under normoxic conditions. 8th World Biomaterials Congress 2008 vol. 1, Lee D and Schroeder J (2008). Phenotypic analysis of Arabidopsis mutants: heavy metal stress. Cold Spring Harbor Laboratory Cold Spring Harbor Protocols vol. 2008, (9) 10.1101/pdb.prot4971Heywood HK and Lee DA (2008). Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun vol. 373, (2) 224-229. 10.1016/j.bbrc.2008.06.011Maeda E, Shelton JC, Bader DL and Lee DA (2008). Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials vol. 16, (SUPPL. 3) Heywood HK and Lee DA (2008). The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture. European Cells and Materials vol. 16, (SUPPL. 3) Chowdhury TT, Salter DM, Bader DL and Lee DA (2008). Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. Inflamm Res vol. 57, (7) 306-313. 10.1007/s00011-007-7126-yHughes D, Whitaker Y, Lee D and Eckhause J (2008). Advantages, Disadvantages, and Uses of Generalized Activity Networks for Schedule Estimation. Military Operations Research Society Military Operations Research vol. 13, (3) 27-40. 10.5711/morj.13.3.27Campbell JJ, Bader DL and Lee DA (2008). Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cells. J Appl Biomater Biom vol. 6, (1) 9-15. 10.1177/228080000800600102Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA (2008). Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther vol. 10, (2) 10.1186/ar2389Chowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA (2008). Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression. Biorheology vol. 45, (3-4) 257-274. 10.3233/BIR-2008-0474Lee DA (2008). Surgeons carry out first implant of pulmonary human heart valve. Biomedical Materials (MAY) 2007
Chowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL and Lee DA (2007). 52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSION. Elsevier Osteoarthritis and Cartilage vol. 15, c42-c43. 10.1016/s1063-4584(07)61688-4Lee D, Redfern O and Orengo C (2007). Predicting protein function from sequence and structure. Springer Nature Nature Reviews Molecular Cell Biology vol. 8, (12) 995-1005. 10.1038/nrm2281Chen Y-H, Chang H-H, Chen Y-J, Lee D, Chiang H-H and Jane Yao C-C (2007). Root contact during insertion of miniscrews for orthodontic anchorage increases the failure rate: an animal study. Wiley Clinical Oral Implants Research 07102500154-???. 10.1111/j.1600-0501.2007.01418.xMaeda E, Shelton JC, Bader DL and Lee DA (2007). Time dependence of cyclic tensile strain on collagen production in tendon fascicles. Biochem Biophys Res Commun vol. 362, (2) 399-404. 10.1016/j.bbrc.2007.08.029Lee DA (2007). Products: CryoLife wins US patent for foam wound sealant. Biomedical Materials (JULY) Lee DA and Hall J (2007). Products: CryoLife wins rights to distribute replacement pericardium. Biomedical Materials (MAR.) Lee DA (2007). Industry news: CryoLife signs Irish distribution deal with Proxy Biomedical. Biomedical Materials (NOV.) 6-7. 2006
Heywood HK, Bader DL and Lee DA (2006). Glucose Concentration and Medium Volume Influences Cell Viability and Glycosaminoglycan Synthesis in Chondrocyte-Seeded Alginate Constructs. Mary Ann Liebert Tissue Engineering 10.1089/ten.2006.12.ft-281Gao J, Yang Y, Lee D, Holdcroft S and Frisken BJ (2006). Self-Assembly of Latex Particles into Proton-Conductive Membranes. American Chemical Society (Acs) Macromolecules vol. 39, (23) 8060-8066. 10.1021/ma060467fScreen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC (2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater vol. 2, (5) 505-513. 10.1016/j.actbio.2006.05.008Akanji OO, Bader DL and Lee DA (2006). Direct current influences Ca 2+ signalling in chondrocytes. European Cells and Materials vol. 11, (SUPPL.2) Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL (2006). Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. Biomech Model Mechan vol. 5, (2-3) 180-191. 10.1007/s10237-006-0020-7Chowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA (2006). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. Biomech Model Mechanobiol vol. 5, (2-3) 192-201. 10.1007/s10237-006-0032-3BRANFORD O, LEE D, BADER D and GROBBELAAR A (2006). 1.3 The quantitative assessment of flexor tendon adhesion – a novel use of confocal microscopy to evaluate local strain, orientation and organisation. Sage Publications Journal of Hand Surgery (European Volume) vol. 31, 3-3. 10.1016/j.jhsb.2006.03.141Lee D (2006). Ground plans [13]. Professional Engineering vol. 19, (6) Marsden RL, Lee D, Maibaum M, Yeats C and Orengo CA (2006). Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space. Oxford University Press (Oup) Nucleic Acids Research vol. 34, (3) 1066-1080. 10.1093/nar/gkj494Heywood HK, Bader DL and Lee DA (2006). Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. Journal of Cellular Physiology vol. 206, (2) 402-410. 10.1002/jcp.20491Marsden RL, Ranea JAG, Sillero A, Redfern O, Yeats C, Maibaum M, Lee D, Addou S, Reeves GA, Dallman TJ and Orengo CA (2006). Exploiting protein structure data to explore the evolution of protein function and biological complexity. The Royal Society Philosophical Transactions of The Royal Society B Biological Sciences vol. 361, (1467) 425-440. 10.1098/rstb.2005.1801Chowdhury TT, Bader DL and Lee DA (2006). Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes. Biochem Biophys Res Commun vol. 339, (1) 241-247. 10.1016/j.bbrc.2005.11.016Knight MM, Toyoda T, Lee DA and Bader DL (2006). Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J Biomech vol. 39, (8) 1547-1551. 10.1016/j.jbiomech.2005.04.006Chowdhury TT, Bader DL and Lee DA (2006). Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology vol. 43, (3,4) 413-429. Bader DL, Lee DA and Knight MM (2006). Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2). Japan Society of Mechanical Engineers The Proceedings of The Bioengineering Conference Annual Meeting of Bed/Jsme vol. 2005.18, 2-3. 10.1299/jsmebio.2005.18.2Chowdhury TT, Raveenthiran SP, Bader DL and Lee DA (2006). P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDE. Elsevier Osteoarthritis and Cartilage vol. 14, 10.1016/s1063-4584(07)60592-5Lee DA and Gridley A (2006). Industry news: CryoLife, BioForm sign glue deal. Biomedical Materials (DEC.) 7-8. Lee DA (2006). Products: Spinal implant looks good so far. Biomedical Materials (JUNE) 4-5. Lee DA (2006). Spinal implants: CryoLife's spinal disc repair study completes enrolment. Biomedical Materials (SEP.) 9-10. Lee DA (2006). Government: US law ensures funding for protein hydrogel development. Biomedical Materials (DEC.) Enobakhare B, Bader DL and Lee DA (2006). Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering. J Appl Biomater Biomech vol. 4, (2) 87-96. 10.1177/2280800006004002032005
Yeats C, Maibaum M, Marsden R, Dibley M, Lee D, Addou S and Orengo CA (2005). Gene3D: modelling protein structure, function and evolution. Oxford University Press (Oup) Nucleic Acids Research vol. 34, (suppl_1) d281-d284. 10.1093/nar/gkj057Screen HRC, Bader DL, Shelton JC and Lee DA (2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194. Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 251-252. Chowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA (2005). Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs. Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 545-546. Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW and Lee DA (2005). Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods. Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 439-440. Bader DL and Lee DA (2005). Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible? 10.1007/1-4020-3741-4_7Pingguan-Murphy B, Lee DA, Bader DL and Knight MM (2005). Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. Arch Biochem Biophys vol. 444, (1) 45-51. 10.1016/j.abb.2005.09.015Screen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Biophys Res Commun vol. 336, (2) 424-429. 10.1016/j.bbrc.2005.08.102Sengers BG, Heywood HK, Lee DA, Oomens CWJ and Bader DL (2005). Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng vol. 127, (5) 758-766. 10.1115/1.1993664Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA (2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng vol. 33, (8) 1090-1099. 10.1007/s10439-005-5777-9Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs. European Cells and Materials vol. 10, (SUPPL.2) Catuogno C, Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs. European Cells and Materials vol. 10, (SUPPL.2) Eniwumide JO, Lee DA and Bader DL (2005). Perfusion-Enhancement of molecular transport within 3D scaffolds. European Cells and Materials vol. 10, (SUPPL.2) Heywood HK, Bader DL and Lee DA (2005). Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate. European Cells and Materials vol. 10, (SUPPL.2) Campbell JJ, Lee DA and Bader DL (2005). Mechanical conditioning Influences Mesenchymal stem cell chondrogenesis. European Cells and Materials vol. 10, (SUPPL.2) Gao J, Lee D, Yang Y, Holdcroft S and Frisken BJ (2005). Self-Assembly of Surface-Charged Latex Nanoparticles: A New Route to the Creation of Continuous Channels for Ion Conduction. American Chemical Society (Acs) Macromolecules vol. 38, (14) 5854-5856. 10.1021/ma050777i (2005). British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK. Wiley International Journal of Experimental Pathology vol. 86, (3) a1-a56. 10.1111/j.0959-9673.2005.00426.xLee D, Grant A, Marsden RL and Orengo C (2005). Identification and distribution of protein families in 120 completed genomes using Gene3D. Wiley Proteins Structure Function and Bioinformatics vol. 59, (3) 603-615. 10.1002/prot.20409Wang Y-N, Bouten CVC, Lee DA and Bader DL (2005). Compression-induced damage in a muscle cell model in vitro. Proc Inst Mech Eng H vol. 219, (1) 1-12. 10.1243/095441105X9246Goldberg AJ, Lee DA, Bader DL and Bentley G (2005). Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture. J Bone Joint Surg Br vol. 87, (1) 128-134. 10.1302/0301-620X.87B1.141542004
Pearl F, Todd A, Sillitoe I, Dibley M, Redfern O, Lewis T, Bennett C, Marsden R, Grant A, Lee D, Akpor A, Maibaum M, Harrison A, Dallman T, Reeves G, Diboun I, Addou S, Lise S, Johnston C, Sillero A, Thornton J and Orengo C (2004). The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis. Oxford University Press (Oup) Nucleic Acids Research vol. 33, (suppl_1) d247-d251. 10.1093/nar/gki024Lee DA, Randall F, Beattie G and Bentall RP (2004). Delusional discourse: An investigation comparing the spontaneous causal attributions of paranoid and non‐paranoid individuals. Wiley Psychology and Psychotherapy Theory Research and Practice vol. 77, (4) 525-540. 10.1348/1476083042555361Bader DL, Shelton JC, Lee DA and SCREEN HRC (2004). Local Strain Measurement within Tendon. Strain vol. 40, (4) 157-163. 10.1111/j.1475-1305.2004.00164.xBryant SJ, Anseth KS, Lee DA and Bader DL (2004). Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res vol. 22, (5) 1143-1149. 10.1016/j.orthres.2004.02.001Chowdhury TT, Salter DM, Bader DL and Lee DA (2004). Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. Biochem Biophys Res Commun vol. 318, (4) 873-881. 10.1016/j.bbrc.2004.04.107Lee D (2004). Debt crisis looms [10]. Professional Engineering vol. 17, (8) Kim B-C, van Gelder H, Kim TA, Lee H-J, Baik KG, Chun HH, Lee DA, Choi KS and Kim S-J (2004). Activin Receptor-like Kinase-7 Induces Apoptosis through Activation of MAPKs in a Smad3-dependent Mechanism in Hepatoma Cells*. Elsevier Journal of Biological Chemistry vol. 279, (27) 28458-28465. 10.1074/jbc.m313277200Bryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS (2004). Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng vol. 32, (3) 407-417. 10.1023/b:abme.0000017535.00602.caLEE DA, van Osch G, Verhaar JAN, Mandl EW, van der Linden JC, van der Breevaart Bravenboer J and Weinans H (2004). Extracellular matrix influences the response of chondrocytes to dynamic compression. Trans. Orthop.Rev. Soc vol. 29, 839-839. Lee DA and Knight MM (2004). Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med vol. 100, 307-324. 10.1385/1-59259-810-2:307Screen HRC, Lee DA, Bader DL and Shelton JC (2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proc Inst Mech Eng H vol. 218, (2) 109-119. 10.1243/095441104322984004Bader DL, KNIGHT MM, Bentley G, Kayser M and Holloway I (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12, (1) 17-24. 10.1016/j.joca.2003.09.001Lee DA and Martin I (2004). Bioreactor Culture Techniques for Cartilage-Tissue Engineering. Biopolymer Methods in Tissue Engineering Springer Nature 10.1385/1-59259-428-x:159Wiseman M, Bader DL, Reisler T and Lee DA (2004). Passage in monolayer influences the response of chondrocytes to dynamic compression. Biorheology vol. 41, (3-4) 283-298. Holloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage vol. 12, (1) 17-24. 10.1016/j.joca.2003.09.001Lee DA and Knight MM (2004). Mechanical Loading of Chondrocytes Embedded in 3D Constructs. Cartilage and Osteoarthritis Springer Nature 10.1385/1-59259-810-2:307Heywood HK, Sembi PK, Lee DA and Bader DL (2004). Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng vol. 10, (9-10) 1467-1479. 10.1089/ten.2004.10.1467Grant A, Lee D and Orengo C (2004). Progress towards mapping the universe of protein folds. Springer Nature Genome Biology vol. 5, (5) 10.1186/gb-2004-5-5-107Lee DA, Fefeu S, Edo‐Ukeh AA, Orengo CA and Slingsby C (2004). EyeSite: a semi‐automated database of protein families in the eye. Oxford University Press (Oup) Nucleic Acids Research vol. 32, (suppl_1) d148-d152. 10.1093/nar/gkh0902003
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Berry CC, Shelton JC, Bader DL and Lee DA (2002). The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels. Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products Lee DA (2002). The design of bioreactor systems for cartilage tissue engineering. Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products Turner JEH, Allington‐Smith J, Chapman S, Content R, Done C, Haynes R, Lee D and Morris S (2002). The origin of [Fe ii] emission in NGC 4151. Oxford University Press (Oup) Monthly Notices of The Royal Astronomical Society vol. 331, (2) 284-292. 10.1046/j.1365-8711.2002.05214.xKnight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H and Bader DL (2002). Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus. Biochim Biophys Acta vol. 1570, (1) 1-8. 10.1016/s0304-4165(02)00144-7Pearl FMG, Lee D, Bray JE, Buchan DWA, Shepherd AJ and Orengo CA (2002). The CATH extended protein‐family database: Providing structural annotations for genome sequences. Wiley Protein Science vol. 11, (2) 233-244. 10.1110/ps.16802BADER DL, Shelton JC, Lee DA and Screen HRC (2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, 361-368. Bader DL, Shelton JC, Lee DA and SCREEN HRC (2002). Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain. Eur. Cells Mat. vol. 4:S1, 41-42. 2001
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Kang SH, Bang Y-J, Im Y-H, Yang H-K, Lee DA, Lee HY, Lee HS, Kim NK and Kim S-J (1999). Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer. Springer Nature Oncogene vol. 18, (51) 7280-7286. 10.1038/sj.onc.1203146Lee DA (1999). Models of government regulation of privatized transit systems in five Latin American cities. Transportation Quarterly vol. 53, (1) 21-39. Haynes R, Lee D, Allington‐Smith J, Content R, Dodsworth G, Lewis I, Sharples R, Turner J, Webster J, Done C, Peletier R, Parry I and Chapman S (1999). Multiple‐Object and Integral Field Near‐Infrared Spectroscopy Using Fibers. Iop Publishing Publications of The Astronomical Society of The Pacific vol. 111, (765) 1451-1468. 10.1086/316459White AET, Bentley G, Stephens MD, Bader DL, Giddins GEB and Lee DA (1999). The effects of storage temperature on the composition, metabolism acid biomechanical properties of human articular cartilage. Knee vol. 6, (3) 197-205. 10.1016/S0968-0160(99)00007-1Lee DA (1999). Introducing Fare Simplification and New Convenience Fares at Connecticut Transit. Sage Publications Transportation Research Record Journal of The Transportation Research Board vol. 1669, (1) 109-112. 10.3141/1669-131998
Lee D (1998). A Tour through through. Sage Publications Journal of English Linguistics vol. 26, (4) 333-351. 10.1177/007542429802600404Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL (1998). Response of chondrocyte subpopulations cultured within unloaded and loaded agarose. J Orthop Res vol. 16, (6) 726-733. 10.1002/jor.1100160615Knight MM, Lee DA and Bader DL (1998). The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose. Biochim Biophys Acta vol. 1405, (1-3) 67-77. 10.1016/s0167-4889(98)00102-5Lee DA, Frean SP, Lees P and Bader DL (1998). Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose. Biochem Bioph Res Co vol. 251, (2) 580-585. 10.1006/bbrc.1998.9520Lee DA and Goodfellow JM (1998). The pH-Induced Release of Iron from Transferrin Investigated with a Continuum Electrostatic Model. Elsevier Biophysical Journal vol. 74, (6) 2747-2759. 10.1016/s0006-3495(98)77983-4Knight MM, Ghori SA, Lee DA and Bader DL (1998). Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. Med Eng Phys vol. 20, (9) 684-688. 10.1016/s1350-4533(98)00080-0Lee DA, Assoku E and Doyle V (1998). A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation. J Mater Sci-Mater M vol. 9, (1) 47-51. 10.1023/a:1008882628142Lao WC, Lee D, Burroughs AK, Lanzani G, Rolles K, Emery VC and Griffiths PD (1998). Erratum: Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation. (Journal of Medical Virology 51 (152-158)). Journal of Medical Virology vol. 54, (1) 1997
Lee DA, Salih V, Stockton EF, Stanton JS and Bentley G (1997). Effect of Normal Synovial Fluid on the Metabolism of Articular Chondrocytes In Vitro. Wolters Kluwer Clinical Orthopaedics and Related Research® vol. 342, (&NA;) 228-238. 10.1097/00003086-199709000-00030Lee D and Recce M (1997). Quantitative Evaluation of the Exploration Strategies of a Mobile Robot. Sage Publications The International Journal of Robotics Research vol. 16, (4) 413-447. 10.1177/027836499701600401Lee DA and Bader DL (1997). Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J Orthop Res vol. 15, (2) 181-188. 10.1002/jor.1100150205O'Neil C, Lee D, Clewley G, Johnson MA and Emery VC (1997). Prevalence of anti‐Vif antibodies in HIV‐1 infected individuals assessed using recombinant baculovirus expressed Vif protein. Wiley Journal of Medical Virology vol. 51, (3) 139-144. 10.1002/(sici)1096-9071(199703)51:3<139::aid-jmv1>3.0.co;2-7Lee DA (1997). Frame conflicts and competing construals in family argument. Elsevier Journal of Pragmatics vol. 27, (3) 339-360. 10.1016/s0378-2166(96)00041-0Lao WC, Lee D, Burroughs AK, Lanzini G, Rolles K, Emery VC and Griffiths PD (1997). Use of polymerase chain reaction to provide prognostic information on human cytomegalovirus disease after liver transplantation. Wiley Journal of Medical Virology vol. 51, (3) 152-158. 10.1002/(sici)1096-9071(199703)51:3<152::aid-jmv3>3.0.co;2-51996
(1996). Preliminary Results From the Cancer Research Campaign Trial Evaluating Tamoxifen Duration in Women Aged Fifty Years or Older With Breast Cancer. Oxford University Press (Oup) Journal of The National Cancer Institute vol. 88, (24) 1834-1839. 10.1093/jnci/88.24.1834Enobakhare BO, Bader DL and Lee DA (1996). Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue. Anal Biochem vol. 243, (1) 189-191. 10.1006/abio.1996.0502Gor D, Lee D and Emery VC (1996). J. Virol. Methods Erratum to “Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase” [61 (1996) 145]. Elsevier Journal of Virological Methods vol. 62, (2) 10.1016/s0166-0934(96)02147-7Gor D, Lee D and Emery VC (1996). Detection of human cytomegalovirus polymerase chain reaction products using oligonucleotide probes directly conjugated to alkaline phosphatase. Elsevier Journal of Virological Methods vol. 61, (1-2) 145-150. 10.1016/0166-0934(96)02081-2Doyle V, Pearson R, Lee D, Wolowacz S and Mc Taggart S (1996). An investigation of the growth of human dermal fibroblasts on poly-L-lactic acid in vitro. Springer Nature Journal of Materials Science: Materials in Medicine vol. 7, (6) 381-385. 10.1007/bf00154554Gorinsky B, Laskowski RA, Lee DA and Bomford A (1996). Conformational analysis of pentapeptide sequences matching a proposed recognition motif for lysosomal degradation. Elsevier Biochimica Et Biophysica Acta vol. 1293, (2) 243-253. 10.1016/0167-4838(95)00256-1Lee D and Sanders M (1996). Implementing a Visioning and Strategic Planning Process at CTTransit. Sage Publications Transportation Research Record Journal of The Transportation Research Board vol. 1521, 58-61. 10.3141/1521-081995
Lee DA and Bader DL (1995). The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes. In Vitro Cell Dev-An vol. 31, (11) 828-835. 10.1007/BF026345651994
Lee DA, Bentley G and Archer CW (1994). Proteoglycan depletion alone is not sufficient to stimulate proteoglycan synthesis in cultured bovine cartilage explants. Elsevier Osteoarthritis and Cartilage vol. 2, (3) 175-185. 10.1016/s1063-4584(05)80067-6Reissis N, Downes S, Kayser M, Lee D and Bentley G (1994). Characterization of the repair tissue in articular cartilage defects using silver-enhanced colloidal gold immunostaining. Springer Nature Journal of Materials Science: Materials in Medicine vol. 5, (6-7) 402-406. 10.1007/bf000589731993
Lee DA, Bentley G and Archer CW (1993). The control of cell division in articular chondrocytes. Elsevier Osteoarthritis and Cartilage vol. 1, (2) 137-145. 10.1016/s1063-4584(05)80029-91991
Lee DA (1991). Categories in the description of just. Elsevier Lingua vol. 83, (1) 43-66. 10.1016/0024-3841(91)90051-61990
Archer CW, Cottrill CP and Lee D (1990). Effects of ascorbate on myogenesis in micromass culture. Springer Nature In Vitro Cellular & Developmental Biology vol. 26, (3) 259-264. 10.1007/bf02624455Lee DA (1990). Digitization of the AT&T worldwide intelligent network. At&Amp;T Technology vol. 5, (1) 14-19. 1989
Jones BM, Evans PM and Lee DA (1989). Relation between the rate of cell movement under agarose and the positioning of cells in heterotypic aggregates. Elsevier Experimental Cell Research vol. 180, (1) 287-296. 10.1016/0014-4827(89)90233-41988
Lee D (1988). INTEGRATED SERVICES DIGITAL NETWORK. British Telecommunications Engineering vol. 7, (pt 2) 2-12. Lee DA (1988). Moth Density and Oviposition Patterns of the European Corn Borer, Ostrinia nubilalis (Lepidoptera: Pyralidae), in Alberta. Oxford University Press (Oup) Environmental Entomology vol. 17, (2) 220-224. 10.1093/ee/17.2.2201987
Lee DA and Spence JR (1987). Reproductive patterns of the European corn borer (Ostrinia nubilalis) in Alberta. Canadian Science Publishing Canadian Journal of Zoology vol. 65, (7) 1733-1740. 10.1139/z87-268Lee D (1987). The semantics of just. Elsevier Journal of Pragmatics vol. 11, (3) 377-398. 10.1016/0378-2166(87)90138-x1983
Lee DA, Winslow NR, Speight AN and Hey EN (1983). Prevalence and spectrum of asthma in childhood. Bmj The Bmj vol. 286, (6373) 10.1136/bmj.286.6373.1256Speight AN, Lee DA and Hey EN (1983). Underdiagnosis and undertreatment of asthma in childhood. Bmj The Bmj vol. 286, (6373) 10.1136/bmj.286.6373.1253Grants
Grants of specific relevance to Predictive in vitro Models
BBSRC IAA Queen Mary University of LondonLee DA and Draviam VM
£300,000 Biotechnology and Biological Sciences Research Council (31-03-2022 - 30-03-2025)
Engineering Circadian Biology into Induced Pluripotent Stem Cell Organ-on-a-Chip ModelsLee DA, Heywood HK, Lin Y-Y and O'Neill JS
£201,874 National Centre for the Replacement Refinement and Reduction of Animals in Research (01-02-2023 - 30-08-2024)
Queen Mary University of London - Flexible Talent Mobility Account 4Lee DA
£80,000 Biotechnology and Biological Sciences Research Council (01-01-2023 - 30-03-2023)
Mechano-circadian rhythmicity - a key component in joint health and diseaseLee DA and Peggrem S
Engineering and Physical Sciences Research Council (24-09-2017 - 30-07-2021)
Super-Resolution Microscopy of live cells in 3DRuban A, Pickersgill RW, Rakyan V, Mullineaux CW, Lee DA, Sharp TV, Alves Godinho SI, Stieglitz B, Hanke GT, Darbari VC, Engl CM, Palacios de Castro MI and Thorpe PH
£369,201 Biotechnology and Biological Sciences Research Council (01-05-2020 - 30-04-2021)
Mechno-regulation of genome function to direct stem cell fateLee DA and Gavara N
£436,193 Biotechnology and Biological Sciences Research Council (01-01-2017 - 31-12-2019)
Augmenting sirtuin activity to drive cartilage regeneration and treat osteoarthritisLee D
£150,201 Dunhill Medical Trust (01-11-2014 - 31-12-2016)
DTA - Queen Mary, University of LondonClarke J, Administrator P, Chadha R, Lee DA, Moran M, Parini C and White SA
£860,487 Engineering and Physical Sciences Research Council (30-09-2008 - 29-09-2012)
Mechanoregulation of nuclear architecture and genome function: A novel mechanism in stem cell fateLee DA, Mauck RL, Discher DE and Cremer T
International Human Frontier Science Program Organization (01-05-2009 - 30-04-2012)
Platform Grant: Multiscale Mechanobiology for Tissue EngineeringLee DA, Knight MM and Heywood H
£995,000 Engineering and Physical Sciences Research Council (30-04-2007 - 29-04-2012)
Queen Mary, University of London - Discipline Bridging InitiativeLee DA
£355,732 Medical Research Council (01-11-2006 - 30-10-2010)
The modulation of metabolic phenotype in chondrocytes during monolayer expansion in relation to synthetic phenotypic stability, oxidative stress and proliferative senescence.Lee DA and Heywood H
£318,498 Wellcome Trust (01-02-2007 - 31-08-2010)
Interleukin-1B and dynamic compressive strain influence the release of nitric oxide and prostaglandin E2 from articular chondrocyte sub-populations via distinct but interacting intracellular signalling pathways.Salter DM, Bader DL and Lee DA
£59,557 Wellcome Trust (01-10-2004 - 31-10-2008)
Interleukin-1B and dynamic compressive strain influence the release of nitric oxide and prostaglandin E2 from articular chondrocyte sub-populations via distinct but interacting intracellular signalling pathways.Lee DA, Bader DL and Salter DM
£175,211 Wellcome Trust (01-07-2004 - 31-01-2008)