Dr Oliver Pearce
Reader in Tumour Extracellular Matrix
Centre for Tumour Microenvironment, Barts Cancer Institute
Queen Mary University of London
Queen Mary University of London
Research
Extracellular matrix, Immunity, decellularised tissue models
Interests
We make decellularised models from human cancer tissues to explore how the tumour immune infiltrate is orientated and activated by the extracellular matrix. I run a service providing access to decellularised models and associated assays. www.matrixdynamics.co.ukPublications
2024
Abstract C045: The extracellular matrix glycoprotein periostin supports chemotherapy resistance by modulating macrophage recruitment and phagocytosis in triple negative breast cancerTarantola L, Keklikoglou I, Pearce OM
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (22_Supplement), c045-c045.
17-11-2024
Tumor's Digest: Macrophage Metabolism Creates a Barrier to T Cells.Tyler EJ, Pearce OMT
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (20), 3322-3323.
26-08-2024
Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin SulfateCancer Research Communications, American Association For Cancer Research (Aacr) vol. 4 (4), 970-985.
03-04-2024
A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic CancerAdvanced Healthcare Materials, Wiley vol. 13 (17)
22-03-2024
2023
A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer CellsVerbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR, Knight MM
Advanced Science, Wiley vol. 11 (2)
15-11-2023
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and functionCarter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Dijke PT, Cameron AJ et al.
The Journal of Pathology, Wiley vol. 262 (1), 90-104.
06-11-2023
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and functionCarter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, Dijke PT, Cameron A et al.
Pancreatology, Elsevier vol. 23 (4), e13-e14.
01-06-2023
Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasisNature Communications, Springer Nature vol. 14 (1)
15-05-2023
Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancerCancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 5841-5841.
04-04-2023
Abstract 1339: Targeting specific extracellular matrix proteins to reactivate T cell trafficking in triple-negative breast cancerGauthier V, Tyler E, Liu Y, Sharp TV, Pearce OM
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 1339-1339.
04-04-2023
Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UKNolan J, Pearce OMT, Screen HRC, Knight MM, Verbruggen SW
Cancers, Mdpi Ag vol. 15 (3), 635-635.
19-01-2023
2022
YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expressionMeng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N, Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 31 (5), 600-612.
08-11-2022
Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockadeStanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 14 (669), eabj1270-eabj1270.
02-11-2022
Editorial: Glycans: Masters of immunity, from cancers to inflammatory diseaseBeatson R, Läubli H, Pearce OMT, Reis CA
Frontiers in Immunology, Frontiers vol. 13
17-08-2022
Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing ModelsSarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O et al.
Biomolecules, Mdpi vol. 12 (6)
16-06-2022
Building in vitro 3D human multicellular models of high-grade serous ovarian cancerMalacrida B, Pearce OMT, Balkwill FR
Star Protocols, Elsevier vol. 3 (1)
11-01-2022
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasionCell Reports, Elsevier vol. 38 (4)
01-01-2022
2021
TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian CancerTGFBI and Ovarian CancerCancer Research, American Association For Cancer Research (Aacr) vol. 81 (22), 5706-5719.
24-09-2021
Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of CancerHirani P, Gauthier V, Allen CE, Wight TN, Pearce OMT
Frontiers in Oncology, Frontiers vol. 11
30-08-2021
Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancerMalacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR
01-07-2021
Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell PhenotypeVerbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR, Knight MM
Cancers, Mdpi Ag vol. 13 (12), 2906-2906.
10-06-2021
A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasionIscience, Elsevier vol. 24 (6)
29-05-2021
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancerDelaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT et al.
Iscience, Elsevier vol. 24 (6)
29-05-2021
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancerDelaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O et al.
Biorxiv.Org
02-02-2021
Basement membrane stiffness determines metastases formationReuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L et al.
Nature Materials, Springer Nature vol. 20 (6), 892-903.
25-01-2021
2020
A Sweet Approach to Heat Up Cancer Response to ImmunotherapyPearce OMT, Läubli H
Cancer Discovery, American Association For Cancer Research (Aacr) vol. 10 (12), 1789-1790.
01-12-2020
FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancerZaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D et al.
Embo Molecular Medicine vol. 12 (11)
06-11-2020
FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancerZaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant‐Sourdy S, Rochotte J, Brunel A, Schlaepfer D et al.
Embo Molecular Medicine, Springer Nature vol. 12 (11)
07-10-2020
Versican—A Critical Extracellular Matrix Regulator of Immunity and InflammationWight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE, Frevert CW
Frontiers in Immunology, Frontiers Media vol. 11
24-03-2020
Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to TreatmentManiati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al.
Ssrn Electronic Journal, Elsevier Bv
14-01-2020
2018
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using ProteomicsJournal of Proteome Research vol. 16 (8), 3083-3091.
01-12-2018
Abstract A31: Mutant p53 increases integrin-ECM interactions in early HGSOCLecker LS, Trevisan C, Delaine-Smith R, Maniati E, Pearce O, Meinert C, Iwanicki M, Drapkin R et al.
01-08-2018
Cancer ImmunotherapyPearce OMT, Läubli H
Glycobiology, Oxford University Press (Oup) vol. 28 (9), 638-639.
10-07-2018
Cancer glycan epitopes: biosynthesis, structure, and function.Pearce OM
Glycobiology
13-03-2018
Investigating the tumour ECM in the inhibition of anti-tumour immunityPuttock E, Rastrick J, White A, Pearce OMT
01-01-2018
Investigating drivers of the tumour matrisome, and their role in disease progressionPearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM et al.
01-01-2018
2017
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.Cancer Discov
01-12-2017
N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils.Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A
Proc Natl Acad Sci U S A vol. 114 (39), E8155-E8164.
26-09-2017
Abstract 5558: Deconstruction of a human tumor microenvironmentBalkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M
01-07-2017
2016
A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases.Clinical Cancer Research, American Association For Cancer Research
27-06-2016
Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinomaClinical Cancer Research, American Association For Cancer Research
01-04-2016
2015
Sialic acids in cancer biology and immunityPearce OMT, Läubli H
Glycobiology, Oxford University Press (Oup) vol. 26 (2), 111-128.
30-10-2015
Interleukin-6 Stimulates Defective AngiogenesisGopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 75 (15), 3098-3107.
01-08-2015
Abstract 4162: Interleukin–6 stimulates defective angiogenesisGopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 75 (15_Supplement), 4162-4162.
01-08-2015
Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin*Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OMT, Kiso M, Miyagi T, Sawada M et al.
Journal of Biological Chemistry, Elsevier vol. 290 (21), 13202-13214.
06-03-2015
Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigensPearce OMT, Samraj AN, Läubli H, Varki NM, Varki A
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 112 (12), e1405-e1405.
20-02-2015
Siglec receptors impact mammalian lifespan by modulating oxidative stressSchwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X et al.
Elife, Elife vol. 4
01-01-2015
2014
A red meat-derived glycan promotes inflammation and cancer progressionSamraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 112 (2), 542-547.
29-12-2014
Abstract 3659: Engagement of myelomonocytic siglecs by tumor-associated ligands modulates innate immune responses to cancerLäubli H, Pearce OMT, Schwarz F, Deng L, Stanczak M, Deng L, Verhagen A, Secrest P et al.
01-10-2014
Abstract 1063: Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodiesPearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Crocker PR, Varki N, Bui J et al.
01-10-2014
Abstract LB-156: A diet-derived sialic acid promotes inflammation and hepatocellular cancerSamraj AN, Laubli H, Pearce O, Secrest P, Garcia-Bingman AE, Varki N, Varki A
01-10-2014
Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancerLäubli H, Pearce OMT, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Deng L, Verhagen A et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (39), 14211-14216.
15-09-2014
Hormesis in cancer immunologyPearce OM, Läubli H, Bui J, Varki A
Oncoimmunology, Taylor & Francis vol. 3 (6)
01-06-2014
Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodiesPearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (16), 5998-6003.
07-04-2014
Discovery of novel monosaccharides in animal glycans: natural occurrence of N‐glycolylhexosamines (607.6)Bergfeld A, Lawrence R, Diaz S, Pearce O, van Vleet J, Esko J, Choudhury B, Varki A
The Faseb Journal, Wiley vol. 28 (S1)
01-04-2014
2013
Enhanced T Cell Function in a Mouse Model of Human GlycosylationBuchlis G, Odorizzi P, Soto PC, Pearce OMT, Hui DJ, Jordan MS, Varki A, Wherry EJ et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 191 (1), 228-237.
01-07-2013
2012
Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID*Bergfeld AK, Pearce OMT, Diaz SL, Pham T, Varki A
Journal of Biological Chemistry, Elsevier vol. 287 (34), 28865-28881.
12-06-2012
Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups RESISTANCE OF α2–8-LINKED N-GLYCOLYLNEURAMINIC ACID TO ENZYMATIC CLEAVAGE*Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C et al.
Journal of Biological Chemistry, Elsevier vol. 287 (34), 28917-28931.
12-06-2012
Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups INCORPORATION OF N-GLYCOLYLHEXOSAMINES INTO MAMMALIAN GLYCANS BY FEEDING N-GLYCOLYLGALACTOSAMINE*Bergfeld AK, Pearce OMT, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A
Journal of Biological Chemistry, Elsevier vol. 287 (34), 28898-28916.
12-06-2012
Intracellular fate of the non‐human sialic acid N‐glycolylneuraminic acidBergfeld AK, Pearce OMT, Diaz S, Pham T, Varki A
01-04-2012
Unusual chemical and enzymatic stability of polysialic acid containing N‐glycolylneuraminic acidDavies L, Pearce O, Tessier M, Assar S, Smutova V, Pshezhetsky A, Woods R, Varki A
The Faseb Journal, Wiley vol. 26 (S1), 610.1-610.1.
01-04-2012
Natural occurrence of N-glycolyl-hexosamines in chondroitin/dermatan sulfates in mammalian tissues, derived from the metabolism of N-glycolylneuraminic acidBergfeld AK, Diaz SL, Lawrence R, Pearce OMT, Esko JD, Varki A
01-01-2012
2010
Intrinsically Hyperactive and Hyperproliferative CD8+ T Cells In Cmah-/- Mice as a Model of Human Gene Transfer Responses.Buchlis G, Mingozzi F, Soto PC, Pearce O, Hui DJ, Varki AP, High KA
Blood, American Society of Hematology vol. 116 (21)
19-11-2010
Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucosePearce OMT, Varki A
Carbohydrate Research, Elsevier vol. 345 (9), 1225-1229.
09-04-2010
2005
Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene TransferPearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A, Davis BG
Angewandte Chemie International Edition, Wiley vol. 44 (7), 1057-1061.
01-02-2005
Cover Picture: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. Int. Ed. 7/2005)Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A, Davis BG
Angewandte Chemie International Edition, Wiley vol. 44 (7), 983-983.
01-02-2005
Titelbild: Glycoviruses: Chemical Glycosylation Retargets Adenoviral Gene Transfer (Angew. Chem. 7/2005)Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A, Davis BG
Angewandte Chemie, Wiley vol. 117 (7), 1005-1005.
01-02-2005
Grants
Grants of specific relevance to Predictive in vitro ModelsLaverock - Tumour modelsOliver Pearce, Elly Tyler, Marcos Burger Ramos and Katie Thornton
£121,315 Laverock Therapeutics Ltd
24-04-2024 - 30-09-2025
Epigenetic targeting in pancreatic ductal adenocarcinoma (PDAC) to overcome resistance to ICBOliver Pearce
£252,508 Barts and the London Charity
01-09-2023 - 31-08-2026
Epigenetic targeting of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma (PDAC) toOliver Pearce and Angus Cameron
£390,550 Barts and the London Charity
01-06-2023 - 31-05-2026
Restoring response to immunotherapy by targeting the extracellular matrixOliver Pearce
£813,041 CR-UK Cancer Research UK
01-07-2019 - 31-12-2025
KTP with LiftBioSciences: 3D TME model to study neutrophil cytotoxicity (PI: Luigi Ombrato)Luigi Ombrato and Oliver Pearce
£232,790 Innovate UK
30-08-2023 - 29-08-2025
Identifying a breast ageing ECM signature to inform a 3D ageing tissue model.Elly Tyler and Oliver Pearce
£4,897 BBSRC Biotechnology and Biological Sciences Research Council
01-04-2023 - 31-12-2023
Identifying opportunities for targeting HLA-G immune checkpoint axisOliver Pearce and David Propper
£189,483 UCB Pharma SPRL
02-05-2022 - 01-05-2023
Engineering a new versican remodeling recombinant bacterial product to enable immunotherapy success in triple negative breast cancerOliver Pearce
£133,227 Innovate UK
01-05-2022 - 30-04-2024
Organ-on-a-chip model of breast cancer bone metastasesMartin Knight and Oliver Pearce
£268,711 CR-UK Cancer Research UK
01-01-2021 - 30-06-2024
Investigating how versican structure relates to its immunological function - tuition feesOliver Pearce
£17,500 Against Breast Cancer
01-10-2020 - 30-09-2024
CiTI-Pro-senescence therapies for basal-like breast cancer: A novel therapeutic innovationCleo Bishop, Oliver Pearce and John Connelly
£242,221 Barts and the London Charity
01-07-2020 - 31-05-2024
Investigating how versican structure relates to its immunological functionOliver Pearce
£141,847 Barts and the London Charity
01-10-2019 - 30-09-2023
Characterising the glycan shield of the tumour extracellular matrixOliver Pearce
£45,256 Against Breast Cancer
01-01-2018 - 31-12-2018
Investigating the tumour extracellular matrix in the inhibition of anti-tumour imunityOliver Pearce and Fran Balkwill
£113,891 UCB Pharma SPRL
01-10-2017 - 28-02-2021