Publications

Publications of specific relevance to Predictive in vitro Models
2023

Diaz-Lopez RA, Wen PH and
Shelton JC (2023).
Influence of Taper surface topographies on contact deformation and stresses. Journal of The Mechanical Behavior of Biomedical Materials vol. 148,
10.1016/j.jmbbm.2023.1062132022

Diaz-Lopez RA, Wen PH and
Shelton JC (2022).
Influence of taper design and loading on taper micromotion. Elsevier Journal of The Mechanical Behavior of Biomedical Materials vol. 128,
10.1016/j.jmbbm.2022.1051062021

Wu H, Wang Z, Liu S, Meng H,
Shelton JC, Thompson CL, Fu S and
Knight MM (2021).
Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening. Biochem Biophys Res Commun 10.1016/j.bbrc.2021.03.1572020

Xu J, Yang J, Chen J, Zhang X, Wu Y, Hart A, Nyga A and
Shelton JC (2020).
Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplasty. Biomed Central Particle and Fibre Toxicology vol. 17, (1) 42-42.
10.1186/s12989-020-00374-y
Di Federico E, Bader DL and
Shelton JC (2020).
3D models of chondrocytes within biomimetic scaffolds: Effects of cell deformation from loading regimens. Elsevier Bv Clinical Biomechanics 10.1016/j.clinbiomech.2020.01.0222019

VADGAMA PM (2019).
An electrochemical study of acrylate bone adhesive permeability and selectivity change during in vitro ageing: a model approach to the study of biomaterials and membrane barriers. Elsevier Masson Analytica Chimica Acta 10.1016/j.acax.2019.1000092018

Xu J, Nyga A,
Li W, Zhang X, Gavara N,
Knight MM and
Shelton JC (2018).
Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. European Cells and Materials vol. 36, 142-155.
10.22203/eCM.v036a11
SHELTON JC (2018).
Prediction of taper performance using quasi static FE models: The influence of loading and taper clearance and trunnion length. Journal of Biomedical Materials Research: Part B - Applied Biomaterials 10.1002/jbm.b.34104
SHELTON JC (2018).
Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated downregulation of RhoA expression. Elsevier Acta Biomaterialia vol. 72, 434-446.
10.1016/j.actbio.2018.03.054
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L,
Knight MM and
Shelton JC (2018).
Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. Acta Biomater vol. 72, 434-446.
10.1016/j.actbio.2018.03.0542017

Clarke I,
Shelton J, Bowsher J, Savisaar C and Donaldson T (2017).
Simulator Study of MOM using Steep-cup Flexion - A Clinically Relevant Incorporation of Intermittent Edge-loading. Joint Implant Surgery and Research Foundation Reconstructive Review vol. 7, (3)
10.15438/rr.7.3.190
Di Federico E,
SHELTON JC and Bader DL (2017).
Complex mechanical conditioning of cell-seeded agarose constructs can influence chondrocyte biosynthetic activity. Wiley Biotechnology and Bioengineering 10.1002/bit.262732016

De Villiers D and
Shelton JC (2016).
Measurement outcomes from hip simulators. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 230, (5) 398-405.
10.1177/09544119166285592015

De Villiers D, Traynor A, Collins SN and
Shelton JC (2015).
The increase in cobalt release in metal-on-polyethylene hip bearings in tests with third body abrasives. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 229, (9) 611-618.
10.1177/0954411915595433
de Villiers D, Traynor A, Collins SN, Banfield S, Housden J and
Shelton JC (2015).
Chromium nitride coating for large diameter metal-on-polyethylene hip bearings under extreme adverse hip simulator conditions. Wear vol. 328-329, 363-368.
10.1016/j.wear.2015.02.0602014

Di Federico E, Bader DL and
Shelton JC (2014).
Design and validation of an in vitro loading system for the combined application of cyclic compression and shear to 3D chondrocytes-seeded agarose constructs. Med Eng Phys vol. 36, (4) 534-540.
10.1016/j.medengphy.2013.11.007
Hothi HS, Busfield JJC and
Shelton JC (2014).
Deformation of uncemented metal acetabular cups following impaction: Experimental and finite element study. Computer Methods in Biomechanics and Biomedical Engineering vol. 17, (11) 1261-1274.
10.1080/10255842.2012.7443972013
2012

Lu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J and
Shelton JC (2012).
Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test. Journal of Materials Science: Materials in Medicine vol. 23, (4) 891-901.
10.1007/s10856-012-4573-y
Lu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J and
Shelton JC (2012).
Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test. Journal of Materials Science: Materials in Medicine 1-11.
2011

Morris B, Zou L, Royle M, Simpson D and
Shelton JC (2011).
Quantifying the wear of acetabular cups using coordinate metrology. Wear vol. 271, (7-8) 1086-1092.
10.1016/j.wear.2011.05.014
Hothi HS, Busfield JJC and
Shelton JC (2011).
Explicit finite element modelling of the impaction of metal press-fit acetabular components. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 225, (3) 303-314.
10.1243/09544119JEIM8642010

McConlogue T, Mueller J and
Shelton J (2010).
Challenges of developing engineering students' writing through peer assessment. Engineering Education 2010: Inspiring The Next Generation of Engineers, Ee 2010 
Maeda E, Fleischmann C, Mein CA,
Shelton JC, Bader DL and
Lee DA (2010).
Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research vol. 51, (6) 434-444.
10.3109/030082010035970562009

Maeda E,
Shelton JC, Bader DL and
Lee DA (2009).
Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering vol. 4, (4) 510-517.
10.1299/jbse.4.510
Angadji A, Royle M, Collins SN and
Shelton JC (2009).
Influence of cup orientation on the wear performance of metal-on-metal hip replacements. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 223, (4) 449-457.
10.1243/09544119JEIM518
Maeda E,
Shelton JC, Bader DL and
Lee DA (2009).
Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology vol. 106, (2) 506-512.
10.1152/japplphysiol.90981.2008
Berry CC,
Shelton JC and
Lee DA (2009).
Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med vol. 3, (1) 43-53.
10.1002/term.1332008

Toorani S,
Shelton JC and
Screen HRC (2008).
Characterizing structure-function relationships in tendon. 8th World Biomaterials Congress 2008 vol. 2,

Angadji A, Grossmann H, Royle M, Collins SN and
Shelton JC (2008).
Affect of cup positioning on the wear performance and wear particles from metal-on-metal hip replacements. 8th World Biomaterials Congress 2008 vol. 2,

Maeda E,
Shelton JC, Bader DL and
Lee DA (2008).
Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials vol. 16, (SUPPL. 3)

Schulz RM, Wüstneck N, Van Donkelaar CC,
Shelton JC and Bader A (2008).
Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnology and Bioengineering vol. 101, (4) 714-728.
10.1002/bit.21955
Mootanah R, Jarrett P, Ingle P, Cheah K, Dowell JK and
Shelton JC (2008).
Configuration of anchorage holes affects cemented fixation of the acetabular component in total hip replacement: an in vitro study. Technol Health Care vol. 16, (1) 19-30.
10.3233/thc-2008-161032007

Mootanah R, Dowell JK, Cheah K, Ingle P and
Shelton JC (2007).
Configuration of anchorage holes affects fixation of the acetabular component in cemented total hip replacement--a finite element study. Comput Methods Biomech Biomed Engin vol. 10, (6) 439-445.
10.1080/10255840701633943
Maeda E,
Shelton JC, Bader DL and
Lee DA (2007).
Time dependence of cyclic tensile strain on collagen production in tendon fascicles. Biochem Biophys Res Commun vol. 362, (2) 399-404.
10.1016/j.bbrc.2007.08.0292006

Bowsher JG, Nevelos J, Williams PA and
Shelton JC (2006).
'Severe' wear challenge to 'as-cast' and 'double heat-treated' large-diameter metal-on-metal hip bearings. P I Mech Eng H vol. 220, (H2) 135-143.
10.1243/09544119JEIM81
Bowsher JG, Hussain A, Williams PA and
Shelton JC (2006).
Metal-on-metal hip simulator study of increased wear particle surface area due to 'severe' patient activity. Proc Inst Mech Eng H vol. 220, (2) 279-287.
10.1243/09544119JEIM932005
Screen HRC, Bader DL,
Shelton JC and
Lee DA (2005).
Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194.
2004

Bowsher JG, Hussain A, Williams P, Nevelos J and
Shelton JC (2004).
Effect of ion implantation on the tribology of metal-on-metal hip prostheses. J Arthroplasty vol. 19, (8 Suppl 3) 107-111.
10.1016/j.arth.2004.09.021
Silwood CJL, Chikanza IC,
Tanner KE,
Shelton JC, Bowsher JG and Grootveld M (2004).
Investigation of the molecular nature of low-molecular-mass cobalt(II) ions in isolated osteoarthritic knee-joint synovial fluid. Free Radic Res vol. 38, (6) 561-571.
10.1080/10715760410001684630
Mootanah R, Ingle P, Cheah K, Dowell JK and
Shelton JC (2004).
Total hip replacement: Results of a postal survey of current practice on the cement fixation of the acetubular cup in the UK. Hip International vol. 14, (3) 155-162.
10.5301/HIP.2008.32192003
Shelton JC, Bader DL and
Lee DA (2003).
Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs vol. 175, (3) 140-150.
10.1159/000074630
Berry CC, Cacou C,
Lee DA, Bader DL and
Shelton JC (2003).
Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner. Biorheology vol. 40, (1-3) 337-345.
Screen HRC,
Lee DA, Bader DL and
Shelton JC (2003).
Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, (1-3) 361-368.
Chowdhury TT,
LEE DA, Salter DM,
Shelton JC and Bader DL (2003).
alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage vol. 11, (Suppl 1) S2-S3.
Chowdhury TT,
Shelton JC, Bader DL and
LEE DA (2003).
Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs vol. 26, (9) 858-858.
2002

Berry CC,
Shelton JC, Bader DL and
Lee DA (2002).
The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels. Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products 
Kakunai S, Sakamoto T, Sakurai D, Aota Y and
Shelton J (2002).
Profile measurement of worn acetabular cup by holographic contouring. Jsme Int J C-Mech Sy vol. 45, (4) 1028-1032.
10.1299/jsmec.45.1028
SHELTON JC, Revell PA and Mushipe MT (2002).
Enhancement of cancellous bone repair using particulates. Biomaterials vol. 23, 365-370.

BADER DL,
Shelton JC,
Lee DA and
Screen HRC (2002).
Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, 361-368.
SHELTON JC, Revell PA and Mushipe MT (2002).
Comparison of influence of cortical bone repair using autologous and Endobon particulates. J Mats Sci: Materials in Medicine vol. 13, 99-105.

Mushipe MT, Revell PA and
Shelton JC (2002).
The effects of bovine trabecular bone matrix particulates on cortical bone repair. J Mater Sci Mater Med vol. 13, (1) 99-105.
10.1023/a:1013607207410
Bader DL,
Shelton JC,
Lee DA and
SCREEN HRC (2002).
Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain. Eur. Cells Mat. vol. 4:S1, 41-42.
2001

Zou L, Samarawickrama DYD, Jovanovski V and
Shelton JC (2001).
Measurements of sequential impressions of acetabula cups from a total hip joint replacement using a non-contact measurement system. International Journal of Machine Tools & Manufacture vol. 41, (13-14) 2023-2030.
10.1016/S0890-6955(01)00067-0
SHELTON JC and Bowsher JG (2001).
A hip simulator study of the influence of patient activity level on the wear of crosslinked polyethylene under smooth and roughened femoral conditions. Wear vol. 250, (1-2) 167-179.
10.1016/S0043-1648(01)00619-62000

Berry CC, Cacou C,
Shelton JC, Bader DL and
Lee DA (2000).
Biological response of cyclic strain on developed cell seeded collagen gel model. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell 
Mulholland JW, Massey W and
Shelton JC (2000).
Investigation and quantification of the blood trauma caused by the combined dynamic forces experienced during cardiopulmonary bypass. Perfusion vol. 15, (6) 485-494.
10.1177/026765910001500603
Mootanah R, Ingle P, Dowell J, Cheah K and
Shelton JC (2000).
Fixation of the acetabular cup in cemented total hip replacement: improving the anchorage hole profile using finite element method. Technol Health Care vol. 8, (6) 343-355.
10.3233/thc-2000-86031998

Kobayashi E, Doi H, Yoneyama T, Hamanaka H, Gibson IR, Best SM,
Shelton JC and Bonfield W (1998).
Influence of aging heat treatment on mechanical properties of biomedical Ti-Zr based ternary alloys containing niobium. J Mater Sci Mater Med vol. 9, (11) 625-630.
10.1023/a:1008927407556
Mo N and
Shelton JC (1998).
Laser speckle photography to measure surface displacements on cortical bone--verification of an automated analysis system. Med Eng Phys vol. 20, (8) 594-601.
10.1016/s1350-4533(98)00062-91996

Forrest DJ,
Shelton JC and Gregson PJ (1996).
Fatigue failure in a plasma sprayed hydroxyapatite coated titanium alloy. Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 1,

McDougall I, Gregson PJ and
Shelton JC (1996).
Multiaxial fatigue testing of medical grade titanium alloy. Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 1,

Kobayashi E, Doi H, Yoneyama T, Hamanaka H, Best SM,
Shelton JC and Bonfield W (1996).
Alloy-design of titanium-zirconium based alloys containing niobium as biomedical materials. Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 2,

Gong F, Swain P, Kadirkamanathan S, Hepworth C, Laufer J,
Shelton J and Mills T (1996).
Cutting thread at flexible endoscopy. Gastrointest Endosc vol. 44, (6) 667-674.
10.1016/s0016-5107(96)70049-4
Horgan LF,
Shelton JC, O'Riordan DC, Moore DP, Winslet MC and Davidson BR (1996).
Strengths and weaknesses of laparoscopic and open mesh inguinal hernia repair: a randomized controlled experimental study. Br J Surg vol. 83, (10) 1463-1467.
10.1002/bjs.1800831044
Shelton JC and Loukota RA (1996).
Pull-out strength of screws from cortical bone in the maxillo-facial region. J Mater Sci-Mater M vol. 7, (4) 231-235.
10.1007/BF00119736
Kadirkamanathan SS,
Shelton JC, Hepworth CC, Laufer JG and Swain CP (1996).
A comparison of the strength of knots tied by hand and at laparoscopy. J Am Coll Surg vol. 182, (1) 46-54.
1995

KADIRKAMANATHAN SS, LAUFER JG, HEPWORTH CC,
SHELTON JC and SWAIN CP (1995).
ARE KNOTS TIED AT LAPAROSCOPY AS SECURE AS HAND TIED KNOTS. Gastrointest Endosc vol. 41, (4) 432-432.
10.1016/s0016-5107(05)80581-41993

Netti PA,
Shelton JC, Revell PA, Pirie C, Smith S, Ambrosio L, Nicolais L and Bonfield W (1993).
Hydrogels as an interface between bone and an implant. Biomaterials vol. 14, (14) 1098-1104.
10.1016/0142-9612(93)90211-j1991
1990
SHELTON JC, GORMAN D and BONFIELD W (1990).
THE APPLICATION OF HOLOGRAPHY TO EXAMINE PLATED FRACTURE FIXATION SYSTEMS. J Mater Sci-Mater M vol. 1, (3) 146-153.
10.1007/BF007008741989
Shelton JC, Gorman D and Bonfield W (1989).
Double exposure holographic interferometric evaluation of plated fracture systems. Journal of Biomechanics vol. 22, (10)
10.1016/0021-9290(89)90459-4