Prof Julia Shelton
BA, PhDProfessor of Biomechanical Engineering
Director of Operations for Centre for Doctoral Training in Next Generation Organ-on-a-chip technology (COaCT)
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
in vitro models of bone, multiscale modelling, total hip replacements, implant coatings, biomechanics, implant wear
Underpinning Bioengineering, Musculoskeletal Models
Interests
I am interested in the response of the body to implants during physiological use, and how to improve outcomes. This includes the development and testing of innovative coatings for Total Hip Replacements to reduce metal ion release and for these to be antibacterial. In addition we are developing an improved understanding of taper connections in modular implants through multiscale modelling to simulate the interaction of taper surfaces. This links to research using in vitro models and organ-chip technology to study bone remodelling.Publications
Publications of specific relevance to Predictive in vitro Models2023
Influence of Taper surface topographies on contact deformation and stressesDiaz-Lopez RA, Wen PH
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 148
28-10-2023
2022
Influence of taper design and loading on taper micromotionDiaz-Lopez RA, Wen PH, Shelton JC
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 128
29-01-2022
2021
Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.Wu H, Wang Z, Liu S, Meng H, Liu S, Shelton JC, Thompson CL, Fu S et al.
Biochem Biophys Res Commun
15-04-2021
2020
Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplastyXu J, Yang J, Chen J, Zhang X, Wu Y, Hart A, Nyga A, Shelton JC
Particle and Fibre Toxicology, Biomed Central vol. 17 (1), 42-42.
27-08-2020
3D models of chondrocytes within biomimetic scaffolds: Effects of cell deformation from loading regimensDi Federico E, Bader DL, Shelton JC
Clinical Biomechanics, Elsevier Bv
07-02-2020
2019
Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1βFu S, Meng H, Freer F, Kwon J, Shelton JC, Knight MM
Clinical Biomechanics, Elsevier vol. 79
24-12-2019
An electrochemical study of acrylate bone adhesive permeability and selectivity change during in vitro ageing: a model approach to the study of biomaterials and membrane barriersVADGAMA PM
Analytica Chimica Acta, Elsevier Masson
04-03-2019
2018
Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6Rowson DT, Shelton JC, Screen HRC, Knight MM
Scientific Reports, Springer Nature vol. 8 (1)
23-07-2018
Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophagesXu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC
European Cells and Materials vol. 36, 142-155.
01-07-2018
Prediction of taper performance using quasi static FE models: The influence of loading and taper clearance and trunnion lengthSHELTON JC
Journal of Biomedical Materials Research: Part B - Applied Biomaterials
10-04-2018
Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM et al.
Acta Biomater vol. 72, 434-446.
09-04-2018
Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated downregulation of RhoA expressionSHELTON JC
Acta Biomaterialia, Elsevier vol. 72, 434-446.
09-04-2018
2017
Simulator Study of MOM using Steep-cup Flexion - A Clinically Relevant Incorporation of Intermittent Edge-loadingClarke I, Shelton J, Bowsher J
Reconstructive Review, Portico vol. 7 (3), 190-190.
01-10-2017
Complex mechanical conditioning of cell-seeded agarose constructs can influence chondrocyte biosynthetic activityDi Federico E, SHELTON JC, Bader DL
Biotechnology and Bioengineering, Wiley
23-03-2017
2016
Measurement outcomes from hip simulatorsde Villiers D, Shelton JC
Proceedings of The Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, Sage Publications vol. 230 (5), 398-405.
17-02-2016
2015
The increase in cobalt release in metal-on-polyethylene hip bearings in tests with third body abrasivesde Villiers D, Traynor A, Collins SN, Shelton JC
Proceedings of The Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, Sage Publications vol. 229 (9), 611-618.
15-07-2015
Chromium nitride coating for large diameter metal-on-polyethylene hip bearings under extreme adverse hip simulator conditionsde Villiers D, Traynor A, Collins SN, Banfield S, Housden J, Shelton JC
Wear, Elsevier vol. 328, 363-368.
01-04-2015
2014
Design and validation of an in vitro loading system for the combined application of cyclic compression and shear to 3D chondrocytes-seeded agarose constructs.Di Federico E, Bader DL, Shelton JC
Med Eng Phys vol. 36 (4), 534-540.
01-04-2014
2013
Microstructural stress relaxation mechanics in functionally different tendons.Screen HRC, Toorani S, Shelton JC
Med Eng Phys vol. 35 (1), 96-102.
01-01-2013
Microstructural stress relaxation mechanics in functionally different tendonsScreen HRC, Toorani S, Shelton JC
Medical Engineering and Physics vol. 35 (1), 96-102.
01-01-2013
2012
Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator testLu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J, Shelton JC
Journal of Materials Science Materials in Medicine vol. 23 (4), 891-901.
01-04-2012
Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator testLu F, Royle M, Lali FV, Hart AJ, Housden J
Journal of Materials Science: Materials in Medicine, 1-11.
01-01-2012
Deformation of uncemented metal acetabular cups following impaction: Experimental and finite element studyHothi HS, Busfield JJC, Shelton JC
Computer Methods in Biomechanics and Biomedical Engineering
01-01-2012
2011
Quantifying the wear of acetabular cups using coordinate metrologyMorris B, Zou L, Royle M, Simpson D, Shelton JC
Wear vol. 271 (7-8), 1086-1092.
18-07-2011
Explicit finite element modelling of the impaction of metal press-fit acetabular componentsHothi HS, Busfield JJC, Shelton JC
Proceedings of The Institution of Mechanical Engineers Part H Journal of Engineering in Medicine vol. 225 (3), 303-314.
01-03-2011
2010
Challenges of developing engineering students' writing through peer assessmentMcConlogue T, Mueller J, Shelton J
Engineering Education 2010 Inspiring The Next Generation of Engineers Ee 2010
01-12-2010
Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strainMaeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL, Lee DA
Connective Tissue Research vol. 51 (6), 434-444.
01-12-2010
2009
Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fasciclesMaeda E, Shelton JC, Bader DL, Lee DA
Journal of Biomechanical Science and Engineering vol. 4 (4), 510-517.
01-12-2009
Influence of cup orientation on the wear performance of metal-on-metal hip replacementsAngadji A, Royle M, Collins SN, Shelton JC
Proceedings of The Institution of Mechanical Engineers Part H Journal of Engineering in Medicine vol. 223 (4), 449-457.
01-04-2009
Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitroMaeda E, Shelton JC, Bader DL, Lee DA
Journal of Applied Physiology vol. 106 (2), 506-512.
01-02-2009
Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs.Berry CC, Shelton JC, Lee DA
J Tissue Eng Regen Med vol. 3 (1), 43-53.
01-01-2009
2008
Characterizing structure-function relationships in tendonToorani S, Shelton JC, Screen HRC
8th World Biomaterials Congress 2008 vol. 2
01-12-2008
Affect of cup positioning on the wear performance and wear particles from metal-on-metal hip replacementsAngadji A, Grossmann H, Royle M
8th World Biomaterials Congress 2008 vol. 2
01-12-2008
Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strainMaeda E, Shelton JC, Bader DL, Lee DA
European Cells and Materials vol. 16 (SUPPL. 3)
01-07-2008
Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructsSchulz RM, Wüstneck N, Van Donkelaar CC, Shelton JC, Bader A
Biotechnology and Bioengineering vol. 101 (4), 714-728.
11-01-2008
Configuration of anchorage holes affects cemented fixation of the acetabular component in total hip replacement: an in vitro study.Mootanah R, Jarrett P, Ingle P, Cheah K, Dowell JK, Shelton JC
Technol Health Care vol. 16 (1), 19-30.
01-01-2008
2007
Configuration of anchorage holes affects fixation of the acetabular component in cemented total hip replacement--a finite element study.Mootanah R, Dowell JK, Cheah K, Ingle P, Shelton JC
Comput Methods Biomech Biomed Engin vol. 10 (6), 439-445.
01-12-2007
Time dependence of cyclic tensile strain on collagen production in tendon fascicles.Maeda E, Shelton JC, Bader DL, Lee DA
Biochem Biophys Res Commun vol. 362 (2), 399-404.
19-10-2007
Gene expressions in tendon fascicles subjected to cyclic tensile strainMaeda E, Shelton JC, Bader DL, Lee DA
01-07-2007
The relationship between tendon composition, structure, and mechanical characteristicsToorani S, Shelton JC
01-07-2007
2006
The influence of swelling and matrix degradation on the microstructural integrity of tendon.Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA, Shelton JC
Acta Biomater vol. 2 (5), 505-513.
01-09-2006
'Severe' wear challenge to 'as-cast' and 'double heat-treated' large-diameter metal-on-metal hip bearingsBowsher JG, Nevelos J
P I Mech Eng H vol. 220 (H2), 135-143.
01-02-2006
Metal-on-metal hip simulator study of increased wear particle surface area due to 'severe' patient activity.Bowsher JG, Hussain A, Williams PA, Shelton JC
Proc Inst Mech Eng H vol. 220 (2), 279-287.
01-02-2006
2005
Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen productionScreen HRC, Bader DL, Shelton JC, Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194.
01-12-2005
Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.Screen HRC, Shelton JC, Bader DL, Lee DA
Biochem Biophys Res Commun vol. 336 (2), 424-429.
21-10-2005
The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL, Lee DA
Ann Biomed Eng vol. 33 (8), 1090-1099.
01-08-2005
Cyclic tensile strain upregulates collagen production in isolated tendon fasciclesScreen HRC, Shelton JC, Bader DL, Lee DA
01-06-2005
Blood flow and damage by the roller pumps during cardiopulmonary bypassMulholland JW, Shelton JC
J Fluid Struct vol. 20 (1), 129-140.
01-01-2005
2004
Effect of ion implantation on the tribology of metal-on-metal hip prostheses.Bowsher JG, Hussain A, Williams P, Nevelos J, Shelton JC
J Arthroplasty vol. 19 (8 Suppl 3), 107-111.
01-12-2004
Local Strain Measurement within TendonBader DL, Shelton JC, Lee DA, SCREEN HRC
Strain vol. 40 (4), 157-163.
01-11-2004
Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.Sawae Y, Shelton JC, Bader DL, Knight MM
Ann Biomed Eng vol. 32 (6), 860-870.
01-06-2004
Investigation of the molecular nature of low-molecular-mass cobalt(II) ions in isolated osteoarthritic knee-joint synovial fluidSilwood CJL, Chikanza IC, Tanner KE, Shelton JC, Bowsher JG, Grootveld M
Free Radical Res vol. 38 (6), 561-571.
01-06-2004
Total hip replacement: Results of a postal survey of current practice on the cement fixation of the acetubular cup in the UKMootanah R, Ingle P, Cheah K, Dowell JK, Shelton JC
Hip International vol. 14 (3), 155-162.
01-01-2004
An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.Screen HRC, Lee DA, Bader DL, Shelton JC
Proc Inst Mech Eng H vol. 218 (2), 109-119.
01-01-2004
Metallurgical Considerations in the Wear of Metal-Metal Hip BearingsFisher J, SHELTON JC
Hip International vol. 14, 1-10.
01-01-2004
2003
Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.Chowdhury TT, Bader DL, Shelton JC, Lee DA
Arch Biochem Biophys vol. 417 (1), 105-111.
01-09-2003
Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels.Berry CC, Shelton JC, Bader DL, Lee DA
Tissue Eng vol. 9 (4), 613-624.
01-08-2003
Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear.Bader DL, SHELTON JC, Knight MM, Sawae Y
J Biochemical Engineering Asme
01-01-2003
Mechanical conditioning influences the metabolic response of cell-seeded constructs.Shelton JC, Bader DL, Lee DA
Cells Tissues Organs vol. 175 (3), 140-150.
01-01-2003
alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression.Chowdhury TT, LEE DA, Salter DM, Shelton JC, Bader DL
ETES.
01-01-2003
Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner.Berry CC, Cacou C, Lee DA, Bader DL, Shelton JC
Biorheology vol. 40 (1-3), 337-345.
01-01-2003
Development of a technique to determine strains in tendons using the cell nuclei.Screen HRC, Lee DA, Bader DL, Shelton JC
Biorheology vol. 40 (1-3), 361-368.
01-01-2003
alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression.Chowdhury TT, LEE DA, Salter DM, Shelton JC, Bader DL
Osteoarthritis Cartilage vol. 11 (Suppl 1), S2-S3.
01-01-2003
Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs.Chowdhury TT, Shelton JC, Bader DL, LEE DA
Internat. J. Artificial Organs vol. 26 (9), 858-858.
01-01-2003
The effects on non-collagenous matrix components on tendon fascicle micromechanics.SCREEN HRC, Shelton JC, Bader DL, Lee DA
49th Annual Meeting of the Orthopaedic Research Society.
01-01-2003
2002
The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gelsBerry CC, Shelton JC, Bader DL, Lee DA
Third Smith and Nephew International Symposium Translating Tissue Engineering Into Products
01-12-2002
Profile measurement of worn acetabular cup by holographic contouringKakunai S, Sakamoto T, Sakurai D, Aota Y
Jsme Int J C-Mech Sy vol. 45 (4), 1028-1032.
01-12-2002
The strain behaviour of tendon under tensile load, using cell nuclei as strain markers.SCREEN HRC, Lee DA, Bader DL, Shelton JC
48th Annual Meeting of the Orthopaedic Research Society.
01-01-2002
Enhancement of cancellous bone repair using particulatesSHELTON JC, Revell PA, Mushipe MT
Biomaterials vol. 23, 365-370.
01-01-2002
Development of a technique to determine strains in tendons using the cell nuclei.BADER DL, Shelton JC, Lee DA, Screen HRC
Biorheology vol. 40, 361-368.
01-01-2002
Comparison of influence of cortical bone repair using autologous and Endobon particulatesSHELTON JC, Mushipe MT
J Mats Sci: Materials in Medicine vol. 13, 99-105.
01-01-2002
Comparison between commercial calcium phosphate bone cementsSaadalla ME, Ahad N, Gibson IR, Brown S, Clarke I, Williams P
Bioceramics 14 vol. 218-2, 331-334.
01-01-2002
The effects of bovine trabecular bone matrix particulates on cortical bone repair.Mushipe MT, Revell PA, Shelton JC
J Mater Sci Mater Med vol. 13 (1), 99-105.
01-01-2002
Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain.Bader DL, Shelton JC, Lee DA, SCREEN HRC
Eur. Cells Mat. vol. 4:S1, 41-42.
01-01-2002
Cancellous bone repair using bovine trabecular bone matrix particulates.Mushipe MT, Revell PA, Shelton JC
Biomaterials vol. 23 (2), 365-370.
01-01-2002
2001
Measurements of sequential impressions of acetabula cups from a total hip joint replacement using a non-contact measurement systemZou L, Samarawickrama DYD, Jovanovski V, Shelton JC
International Journal of Machine Tools & Manufacture vol. 41 (13-14), 2023-2030.
01-10-2001
A hip simulator study of the influence of patient activity level on the wear of crosslinked polyethylene under smooth and roughened femoral conditionsSHELTON JC, Bowsher JG
Wear vol. 250 (1-2), 167-179.
01-10-2001
Hip simulator study of the influence of patient activity level on the wear of crosslinked polyethylene under smooth and roughened femoral conditionsBowsher JG
01-10-2001
Influence of training on reliability of surgical knotsInd TEJ, Shepherd JH
Brit J Obstet Gynaec vol. 108 (10), 1013-1016.
01-10-2001
2000
Biological response of cyclic strain on developed cell seeded collagen gel modelBerry CC, Cacou C, Shelton JC, Bader DL, Lee DA
Second Smith and Nephew International Symposium Tissue Engineering 2000 Advances in Tissue Engineering Biomaterials and Cell Sig
01-12-2000
Investigation and quantification of the blood trauma caused by the combined dynamic forces experienced during cardiopulmonary bypass.Mulholland JW, Massey W, Shelton JC
Perfusion vol. 15 (6), 485-494.
01-11-2000
A system for monitoring the response of uniaxial strain on cell seeded collagen gelsCacou C, Palmer D, Lee DA, Bader DL, Shelton JC
Med Eng Phys vol. 22 (5), 327-333.
01-06-2000
Fixation of the acetabular cup in cemented total hip replacement: improving the anchorage hole profile using finite element method.Mootanah R, Ingle P, Dowell J, Cheah K, Shelton JC
Technol Health Care vol. 8 (6), 343-355.
01-01-2000
1998
Influence of aging heat treatment on mechanical properties of biomedical Ti-Zr based ternary alloys containing niobium.Kobayashi E, Doi H, Yoneyama T, Hamanaka H, Gibson IR, Best SM, Shelton JC, Bonfield W
J Mater Sci Mater Med vol. 9 (11), 625-630.
01-11-1998
Laser speckle photography to measure surface displacements on cortical bone--verification of an automated analysis system.Mo N, Shelton JC
Med Eng Phys vol. 20 (8), 594-601.
01-11-1998
Quantification of holographic fringe data: comparison of intact and implanted femurs.Katz DM, Blatcher S, Shelton JC
Med Eng Phys vol. 20 (2), 114-123.
01-03-1998
1996
Fatigue failure in a plasma sprayed hydroxyapatite coated titanium alloyForrest DJ, Shelton JC, Gregson PJ
Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 1
01-12-1996
Multiaxial fatigue testing of medical grade titanium alloyMcDougall I, Gregson PJ, Shelton JC
Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 1
01-12-1996
Alloy-design of titanium-zirconium based alloys containing niobium as biomedical materialsKobayashi E, Doi H, Yoneyama T, Hamanaka H, Best SM, Shelton JC, Bonfield W
Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 2
01-12-1996
Cutting thread at flexible endoscopy.Gong F, Swain P, Kadirkamanathan S, Hepworth C, Laufer J, Shelton J, Mills T
Gastrointest Endosc vol. 44 (6), 667-674.
01-12-1996
Strengths and weaknesses of laparoscopic and open mesh inguinal hernia repair: a randomized controlled experimental study.Horgan LF, Shelton JC, O'Riordan DC, Moore DP, Winslet MC, Davidson BR
Br J Surg vol. 83 (10), 1463-1467.
01-10-1996
Pull-out strength of screws from cortical bone in the maxillo-facial regionShelton JC, Loukota RA
J Mater Sci-Mater M vol. 7 (4), 231-235.
01-04-1996
A comparison of the strength of knots tied by hand and at laparoscopy.Kadirkamanathan SS, Shelton JC, Hepworth CC, Laufer JG, Swain CP
J Am Coll Surg vol. 182 (1), 46-54.
01-01-1996
1995
Mechanical analysis of maxillofacial miniplates.Loukota RA, Shelton JC
Br J Oral Maxillofac Surg vol. 33 (3), 174-179.
01-06-1995
ARE KNOTS TIED AT LAPAROSCOPY AS SECURE AS HAND TIED KNOTSKADIRKAMANATHAN SS, LAUFER JG, SHELTON JC, SWAIN CP
Gastrointest Endosc vol. 41 (4), 432-432.
01-04-1995
1993
Hydrogels as an interface between bone and an implant.Netti PA, Shelton JC, Revell PA, Pirie C, Smith S, Ambrosio L, Nicolais L, Bonfield W
Biomaterials vol. 14 (14), 1098-1104.
01-11-1993
1992
OBTAINING AUTHENTIC RESULTS USING HOLOGRAPHIC-INTERFEROMETRYKATZ DM, BONFIELD W, Little EG
01-01-1992
1991
Laser interferometric techniques in orthopaedics.Shelton JC, Katz DM
J Med Eng Technol vol. 15 (6), 209-221.
01-01-1991
1990
THE APPLICATION OF HOLOGRAPHY TO EXAMINE PLATED FRACTURE FIXATION SYSTEMSSHELTON JC, GORMAN D, BONFIELD W
J Mater Sci-Mater M vol. 1 (3), 146-153.
01-10-1990
1989
Double exposure holographic interferometric evaluation of plated fracture systemsShelton JC, Gorman D, Bonfield W
Journal of Biomechanics vol. 22 (10)
01-01-1989
Grants
Grants of specific relevance to Predictive in vitro Models
EPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 Engineering and Physical Sciences Research Council
Grant Summary

01-07-2024 - 30-09-2032
Organ-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacementHazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research
Grant Summary

07-10-2024 - 14-03-2025


