Use of in vitro Models for Research and Target Identification

A major research focus within the CPM is to develop, validate and qualify advanced models of human diseases with a view to defining underlying pathogenic mechanisms and identifying novel therapeutic targets.  CPM researchers employ complex in vitro systems such as organoids, 3D cultures, and organ-on-chip platforms, alongside patient-derived cells and genome engineering methods, to recreate the microenvironments of human diseases, including cancer, cardiovascular, musculoskeletal and immune-related conditions. These models allow us to study disease mechanisms in human-relevant settings, capturing interactions between multiple cell types, genetic variation, and dynamic cues that are not possible in standard cultures. By integrating advanced imaging, functional readouts, and molecular profiling, our teams are uncovering how diseases progress and respond to interventions. In addition, in vitro disease models are carefully validated against key clinical features and qualified for defined contexts of use.