Dr Vahitha Abdul Salam

Vahitha Abdul Salam

Lecturer

Centre for Cardiovascular Medicine and Device Innovation
Queen Mary University of London
www.qmul.ac.uk/whri/people/academic-staff/items/abdulsalamvahitha.html

Research

Vascular dysfunction, Proteomics, Drug Discovery, Chloride intracellular channel protein, Pulmonary hypertension, Environmental Toxicology

Cancer Models, Cardiovascular Models, Infectious Disease and Inflammation Models, Neuronal Models

Interests

My research involves using multidisciplinary approaches to discover and develop drugs that affect vascular health. For example, I am currently developing inhibitors of chloride intracellular channel proteins as a target for cardiovascular diseases and cancer. In addition, I plan to establish vasculature-on-chip models to validate such inhibitors' use and study the interaction of environmental toxicants on vascular health.

Publications

Publications of specific relevance to Predictive in vitro Models

2023

Alzaydi MM, Abdul-Salam VB, Whitwell HJ, Russomanno G, Glynos A, Capece D, Szabadkai G, Wilkins MR and Wojciak-Stothard B (2023). Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension. American Thoracic Society  American Journal of Respiratory Cell and Molecular Biology  vol. 68, (1) 103-115. 10.1165/rcmb.2022-0111oc

2022

Olotu F, Medina-Carmona E, Serrano-Sanchez A, Ossa F, El-Hamdaoui A, Bishop ÖT, Ortega-Roldan JL and Abdul-Salam VB (2022). Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein. Elsevier  Computational and Structural Biotechnology Journal  vol. 21, 688-701. 10.1016/j.csbj.2022.12.040
Varela L, Hendry AC, Cassar J, Martin-Escolano R, Cantoni D, Ossa F, Edwards JC, Abdul-Salam V and Ortega-Roldan JL (2022). A Zn2+-triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channels. The Company of Biologists  Journal of Cell Science  vol. 135, (15) 10.1242/jcs.259704

2021

Shaikh FS, Aldhafferi N, Buker A, Alqahtani A, Dey S, Abdulhamid S, AlBuhairi DAM, Alkabour RSA, Atiyah WSO, Chrouf SB, Alshehri A, Olatunji SO, Almuhaideb AM, Alshahrani MS, AlMunsour Y and Abdul-Salam VB (2021). Comorbidities and Risk Factors for Severe Outcomes in COVID-19 Patients in Saudi Arabia: A Retrospective Cohort Study. Taylor & Francis  Journal of Multidisciplinary Healthcare  vol. 14, 2169-2183. 10.2147/jmdh.s317884
Medvedev R, Sanchez-Alonso JL, Alvarez-Laviada A, Rossi S, Dries E, Schorn T, Abdul-Salam VB, Trayanova N, Wojciak-Stothard B, Miragoli M, Faggian G and Gorelik J (2021). Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension. Hypertension  vol. 77, (2) 605-616. 10.1161/HYPERTENSIONAHA.120.14858

2020

Russomanno G, Jo KB, Abdul-Salam VB, Morgan C, Endruschat J, Schaeper U, Osman AH, Alzaydi MM, Wilkins MR and Wojciak-Stothard B (2020). miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension. Elsevier  Molecular Therapy - Nucleic Acids  vol. 23, 142-153. 10.1016/j.omtn.2020.10.042
Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R, Bogaard HJ, Morgan CC, Pullamsetti SS, Alzaydi MM, Rhodes CJ, Piva R, Eichstaedt CA, Grünig E, Wilkins MR and Wojciak-Stothard B (2020). Author Correction: Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Nat Commun  vol. 11, (1) 3300-3300. 10.1038/s41467-020-17273-7
Russomanno G, Jo KB, Abdul Salam V, Morgan C, Alzaydi M, Wilkins M and Wojciak-Stothard B (2020). 1 Role of endothelial microRNA-150 in pulmonary arterial hypertension. Biorxiv  10.1101/2020.03.25.007021
Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R, Jan Bogaard H, Morgan CC, Pullamsetti SS, Alzaydi MM, Rhodes CJ, Piva R, Eichstaedt CA, Grünig E, Wilkins MR and Wojciak-Stothard B (2020). Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Springer Nature  Nature Communications  vol. 11, (1) 10.1038/s41467-020-14966-x

2018

Abdul-Salam VB, Russomanno G, Chien-Nien C, Mahomed AS, Yates LA, Wilkins MR, Zhao L, Gierula M, Dubois O, Schaeper U, Endruschat J and Wojciak-Stothard B (2018). CLIC4/Arf6 Pathway A New Lead in BMPRII Inhibition in Pulmonary Hypertension. Circ Res  vol. 124, (1) 52-65. 10.1161/CIRCRESAHA.118.313705
Edwards RJ, Pyzio M, Gierula M, Turner CE, Abdul-Salam VB and Sriskandan S (2018). Proteomic analysis at the sites of clinical infection with invasive Streptococcus pyogenes. Springer Nature  Scientific Reports  vol. 8, (1) 10.1038/s41598-018-24216-2

2017

Duluc L, Ahmetaj-Shala B, Mitchell J, Abdul-Salam VB, Mahomed AS, Aldabbous L, Oliver E, Iannone L, Dubois OD, Storck EM, Tate EW, Zhao L, Wilkins MR and Wojciak-Stothard B (2017). Tipifarnib prevents development of hypoxia-induced pulmonary hypertension. Oxford University Press (Oup)  Cardiovascular Research  vol. 113, (3) 276-287. 10.1093/cvr/cvw258

2016

Aldabbous L, Abdul-Salam V, McKinnon T, Duluc L, Pepke-Zaba J, Southwood M, Ainscough AJ, Hadinnapola C, Wilkins MR, Toshner M and Wojciak-Stothard B (2016). Neutrophil Extracellular Traps Promote Angiogenesis. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 36, (10) 2078-2087. 10.1161/atvbaha.116.307634

2014

Wojciak-Stothard B, Abdul-Salam VB, Lao KH, Tsang H, Irwin DC, Lisk C, Loomis Z, Stenmark KR, Edwards JC, Yuspa SH, Howard LS, Edwards RJ, Rhodes CJ, Gibbs JSR, Wharton J, Zhao L and Wilkins MR (2014). Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension. Wolters Kluwer  Circulation  vol. 129, (17) 1770-1780. 10.1161/circulationaha.113.006797

2010

Abdul-Salam VB, Wharton J, Cupitt J, Berryman M, Edwards RJ and Wilkins MR (2010). Proteomic Analysis of Lung Tissues From Patients With Pulmonary Arterial Hypertension. Wolters Kluwer  Circulation  vol. 122, (20) 2058-2067. 10.1161/circulationaha.110.972745
Paratz E and Abdul Salam V (2010). Investigation of lactate dehydrogenase isoenzymes as candidate biomarkers of idiopathic pulmonary arterial hypertension. Australian Medical Student Journal  vol. 1, 16-20.
Abdul-Salam VB, Ramrakha P, Krishnan U, Owen DR, Shalhoub J, Davies AH, Tang TY, Gillard JH, Boyle JJ, Wilkins MR and Edwards RJ (2010). Identification and Assessment of Plasma Lysozyme as a Putative Biomarker of Atherosclerosis. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 30, (5) 1027-1033. 10.1161/atvbaha.109.199810

2006

Abdul‐Salam VB, Paul GA, Ali JO, Gibbs SR, Rahman D, Taylor GW, Wilkins MR and Edwards RJ (2006). Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension. Wiley  Proteomics  vol. 6, (7) 2286-2294. 10.1002/pmic.200500510