Dr Vahitha Abdul Salam

Vahitha Abdul Salam

Lecturer

Centre for Cardiovascular Medicine and Device Innovation
Queen Mary University of London
www.qmul.ac.uk/whri/people/academic-staff/items/abdulsalamvahitha.html

Research

Vascular dysfunction, Proteomics, Drug Discovery, Chloride intracellular channel protein, Pulmonary hypertension, Environmental Toxicology

Cancer Models, Cardiovascular Models, Infectious Disease and Inflammation Models, Neuronal Models

Interests

My research involves using multidisciplinary approaches to discover and develop drugs that affect vascular health. For example, I am currently developing inhibitors of chloride intracellular channel proteins as a target for cardiovascular diseases and cancer. In addition, I plan to establish vasculature-on-chip models to validate such inhibitors' use and study the interaction of environmental toxicants on vascular health.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2023

Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension.
Alzaydi MM, Abdul-Salam VB, Whitwell HJ, Russomanno G, Glynos A, Capece D, Szabadkai G, Wilkins MR et al.
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society vol. 68 (1), 103-115.  
01-01-2023

2022

Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein
Olotu F, Medina-Carmona E, Serrano-Sanchez A, Ossa F, El-Hamdaoui A, Bishop ÖT, Ortega-Roldan JL, Abdul-Salam VB
Computational and Structural Biotechnology Journal, Elsevier vol. 21, 688-701.  
24-12-2022
A Zn2+-triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channels
Varela L, Hendry AC, Cassar J, Martin-Escolano R, Cantoni D, Ossa F, Edwards JC, Abdul-Salam V et al.
Journal of Cell Science, The Company of Biologists vol. 135 (15) 
01-08-2022

2021

Comorbidities and Risk Factors for Severe Outcomes in COVID-19 Patients in Saudi Arabia: A Retrospective Cohort Study
Shaikh FS, Aldhafferi N, Buker A, Alqahtani A, Dey S, Abdulhamid S, Alkabour RSA, Atiyah WSO et al.
Journal of Multidisciplinary Healthcare, Taylor & Francis vol. 14, 2169-2183.  
01-08-2021
Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.
Medvedev R, Sanchez-Alonso JL, Alvarez-Laviada A, Rossi S, Dries E, Schorn T, Abdul-Salam VB, Trayanova N et al.
Hypertension vol. 77 (2), 605-616.  
01-02-2021

2020

miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension
Russomanno G, Jo KB, Abdul-Salam VB, Morgan C, Endruschat J, Schaeper U, Osman AH, Alzaydi MM et al.
Molecular Therapy - Nucleic Acids, Elsevier vol. 23, 142-153.  
04-11-2020
Author Correction: Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.
Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R et al.
Nat Commun vol. 11 (1), 3300-3300.  
30-06-2020
1 Role of endothelial microRNA-150 in pulmonary arterial hypertension
Russomanno G, Jo KB, Abdul Salam V, Morgan C, Alzaydi M, Wilkins M, Wojciak-Stothard B
Biorxiv 
25-03-2020
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R et al.
Nature Communications, Springer Nature vol. 11 (1) 
04-03-2020

2018

CLIC4/Arf6 Pathway A New Lead in BMPRII Inhibition in Pulmonary Hypertension
Abdul-Salam VB, Russomanno G, Chien-Nien C, Mahomed AS, Yates LA, Wilkins MR, Zhao L, Gierula M et al.
Circ Res vol. 124 (1), 52-65.  
15-10-2018
Proteomic analysis at the sites of clinical infection with invasive Streptococcus pyogenes
Edwards RJ, Pyzio M, Gierula M, Turner CE, Abdul-Salam VB, Sriskandan S
Scientific Reports, Springer Nature vol. 8 (1) 
13-04-2018

2017

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension
Duluc L, Ahmetaj-Shala B, Mitchell J, Abdul-Salam VB, Mahomed AS, Aldabbous L, Oliver E, Iannone L et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 113 (3), 276-287.  
05-01-2017

2016

Neutrophil Extracellular Traps Promote Angiogenesis
Aldabbous L, Abdul-Salam V, McKinnon T, Duluc L, Pepke-Zaba J, Southwood M, Ainscough AJ, Hadinnapola C et al.
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 36 (10), 2078-2087.  
28-07-2016

2014

Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension
Wojciak-Stothard B, Abdul-Salam VB, Lao KH, Tsang H, Irwin DC, Lisk C, Loomis Z, Stenmark KR et al.
Circulation, Wolters Kluwer vol. 129 (17), 1770-1780.  
06-02-2014

2013

Chloride intercellular channel-4 and vascular endothelial inflammatory responses associated with pulmonary arterial hypertension
Abdul Salam V, Gierula M, Edwards RJ, Zhao L
Sixth Annual Scientific Workshops and Debates of the Pulmonary Vascular Research Institute (PVRI) Istanbul 21 Jan 2013 - 25 Jan 2013. 
01-09-2013

2012

Chloride intracellular channel protein 4 in pulmonary endothelial angiogenesis
Abdul-Salam VB, Zhao L, Howard L, Hou LK, Wilkins MR
 
01-05-2012
Chloride Intracellular Channel Protein-4 In The Vascular Dysfunction Of Pulmonary Arterial Hypertension
Salam VBA, Lao KH, Tsang H, Zhao L, Howard LS, Wharton J, Yuspa SH, Wojciak-Stothard B
A29. PATHOGENESIS OF PULMONARY HYPERTENSION. 
01-05-2012

2010

CHLORIDE INTRACELLULAR CHANNEL PROTEIN 4 (CLIC4) INTHE REGULATION OF HUMAN PULMONARY ENDOTHELIALRESPONSES TO HYPOXIA
Abdul Salam V, Wojciak-Stothard B
British Thoracic Society WInter Meeting 2010. 
01-12-2010
Proteomic Analysis of Lung Tissues From Patients With Pulmonary Arterial Hypertension
Abdul-Salam VB, Wharton J, Cupitt J, Berryman M, Edwards RJ, Wilkins MR
Circulation, Wolters Kluwer vol. 122 (20), 2058-2067.  
01-11-2010
Investigation of lactate dehydrogenase isoenzymes as candidate biomarkers of idiopathic pulmonary arterial hypertension
Paratz E, Abdul Salam V
Australian Medical Student Journal vol. 1, 16-20.  
22-04-2010
Identification and Assessment of Plasma Lysozyme as a Putative Biomarker of Atherosclerosis
Abdul-Salam VB, Ramrakha P, Krishnan U, Shalhoub J, Davies AH, Gillard JH, Boyle JJ
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 30 (5), 1027-1033.  
18-02-2010

2006

Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension
Abdul‐Salam VB, Paul GA, Ali JO, Gibbs SR, Rahman D, Taylor GW, Wilkins MR, Edwards RJ
Proteomics, Wiley vol. 6 (7), 2286-2294.  
22-03-2006

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconKTP with WRc: Risk Assessment of Microplastics in Human Health (PI: Vahitha Abdul Salam)
Vahitha Abdul Salam and Kate Spencer
£227,438 Innovate UK
01-08-2023 - 31-07-2025
bullet iconKTP Capacity Building Competition 2022
Akram Alomainy, Greg Slabaugh, Alastair Noyce, Vahitha Abdul Salam and Viji Draviam Sastry
£34,544 Innovate UK
01-12-2022 - 31-03-2023
bullet iconWater Research Centre Pump Priming Award
Vahitha Abdul Salam
£20,000 Water Research Centre
01-04-2022 - 31-03-2023