Dr Sara Caxaria

Sara Caxaria

PDRA

EMR
Queen Mary University of London

Research

Pain, Neuroimmunology, Neutrophils, Regenerative medicine, Osteoarthritis, Bone

Musculoskeletal Models, Neuronal Models

Interests

I have worked with iPSC and differentiated them into hepatic lineage. Part of this work was used to better understand coagulation pathways in the developing liver. I have also worked with in vitro systems to study cartilage formation and regeneration (using both human and mouse cells).

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms
Hestehave S, Florea R, Singleton S, Fedorec AJH, Caxaria S, Morgan OB, Kopp KT, Brown LA et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 122 (44) 
30-10-2025

2024

Novel therapies for cancer-induced bone pain
Haroun R, Gossage SJ, Iseppon F, Fudge A, Caxaria S, Arcangeletti M, Leese C, Davletov B et al.
Neurobiology of Pain, Elsevier vol. 16 
01-07-2024
754 Sex Differences in a Murine Model of Osteoarthritis
Bharde S, Caxaria S, Celik P, Srithasan A, Fuller A, Sikandar S
Osteoarthritis and Cartilage, Elsevier vol. 32 
01-04-2024

2023

Mesenchymal stromal cell secretory molecules improve the functional survival of human islets
Hong T, Caxaria S, Gatward LFD, King AJF, Rackham CL
Diabetic Medicine, Wiley vol. 40 (12) 
03-10-2023
POS0255 A PRO-NOCICEPTIVE POPULATION OF NEUTROPHILS INFILTRATE SENSORY GANGLIA AND MEDIATE CHRONIC WIDESPREAD PAIN IN FIBROMYALGIA SYNDROME
Evans R, Caxaria S, Celik P, Fuller AM, Bharde S, Sikandar S
 
01-06-2023
POS0413 SEX DIFFERENCES IN A MURINE MODEL OF OSTEOARTHRITIS
Bharde S, Caxaria S, Celik P, Sikandar S
 
01-06-2023
Gate control of sensory neurotransmission in peripheral ganglia by proprioceptive sensory neurons
Fuller AM, Luiz A, Tian N, Arcangeletti M, Iseppon F, Sexton JE, Millet Q, Caxaria S et al.
Brain, Oxford University Press (Oup) vol. 146 (10), 4033-4039.  
30-05-2023
Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia
Caxaria S, Bharde S, Fuller AM, Evans R, Thomas B, Celik P, Dell’Accio F, Yona S et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 120 (17), e2211631120-e2211631120.  
18-04-2023

2022

Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine
Caxaria S, Kouvatsos N, Eldridge SE, Alvarez‐Fallas M, Thorup A, Cici D, Barawi A, Arshed A et al.
Embo Molecular Medicine, Springer Nature vol. 15 (1) 
12-12-2022
BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING
Thorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G et al.
Osteoarthritis and Cartilage, Elsevier vol. 30 
01-04-2022
In vivo potency assay for the screening of bioactive molecules on cartilage formation
Thorup A-S, Caxaria S, Thomas BL, Suleman Y, Nalesso G, Luyten FP, Dell’Accio F, Eldridge SE
Lab Animal, Springer Nature vol. 51 (4), 103-120.  
31-03-2022

2021

OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS
Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al.
Annals of The Rheumatic Diseases, Elsevier vol. 80, 120-121.  
01-06-2021
AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B et al.
Annals of The Rheumatic Diseases vol. 80 (Suppl 1), 1052.1-101052.  
19-05-2021
WNT3A‐loaded exosomes enable cartilage repair
Thomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup A, Nalesso G, Caxaria S, Barawi A et al.
Journal of Extracellular Vesicles, Wiley vol. 10 (7) 
01-05-2021
Update on pain in arthritis
Bharde S, Caxaria S, Dell’Accio F, Sikandar S
Current Opinion in Supportive and Palliative Care, Wolters Kluwer vol. 15 (2), 99-107.  
08-04-2021

2020

ROR2 blockade as a therapy for osteoarthritis
Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas BL, Eldridge SE, Nalesso G, Whiteford JR et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 12 (561) 
16-09-2020
Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, Guan Z, Lydon H, Thomas BL et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 12 (559) 
02-09-2020

2018

The role of GCP-2 in cartilage differentiation and repair
Fallas MA, Caxaria S, Sherwood J, Luyten F, Pitzalis C, Dell'Accio F
 
01-04-2018

2017

Agrin inhibits canonical WNT signalling through LRP4
Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al.
 
01-04-2017
The Role of CXCl6 in Cartilage Development and Homeostasis
Caxaria S, Sherwood J, Roeder E, Luyten F, Pitzalis C, Dell'Accio F
 
01-04-2017
A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo
Thorup A-S, Eldridge SE, Caxaria S, Nalesso G, Thomas BL, Pitzalis C, Luyten F, Dell'Accio F
 
01-04-2017

2015

Generation of Integration-Free Patient Specific iPS Cells Using Episomal Plasmids Under Feeder Free Conditions
Caxaria S, Arthold S, Nathwani AC
In Patient-Specific Induced Pluripotent Stem Cell Models, Springer Nature 355-366.  
01-01-2015

2013

A Systematic Evaluation of Integration Free Reprogramming Methods for Deriving Clinically Relevant Patient Specific Induced Pluripotent Stem (iPS) Cells
Goh PA, Caxaria S, Casper C, Rosales C, Warner TT, Coffey PJ, Nathwani AC
Plos One, Public Library of Science (Plos) vol. 8 (11) 
26-11-2013

Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms
Hestehave S, Florea R, Singleton S, Fedorec AJH, Caxaria S, Morgan O, Kopp KT, Brown LA et al.
In Biorxiv 
Paradoxical Phenotype of Fibromyalgia Neutrophils with Elevated Baseline Inflammation but Blunted Response to Stimulation
Esfahani SJ, Oveisi A, Lima LV, Caxaria S, Parisien M, Vignone J, Montagna F, Sikandar S et al.
In Biorxiv 
Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia
Caxaria S, Bharde S, Fuller AM, Evans R, Thomas B, Celik P, Dell’Accio F, Yona S et al.
In Biorxiv 
Novel therapies for cancer-induced bone pain
Haroun R, Gossage SJ, Iseppon F, Fudge A, Caxaria S, Arcangeletti M, Leese C, Davletov B et al.
In Biorxiv 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconInvestigating the role of synovial fibroblasts in the sensitization of articular primary sensory neurons
Sara Caxaria and Shafaq Sikandar
£9,100 Rosetrees Trust
01-03-2024 - 28-02-2025
bullet iconCiTi Dissociating homeostatic and inflammatory roles of neutrophils and chemokine signaling in pain and inflammation
Shafaq Sikandar, Francesco Dell'Accio, Sara Caxaria and Mathieu-Benoit Voisin
£298,013 Barts and the London Charity
01-11-2020 - 31-01-2024