Prof Mauro Perretti

Professor of Immunopharmacology

Research

Immunopharmacology, Inflammation, Arthritis, Joint disease, Fibrosis

Interests

Publications

Publications of specific relevance to Predictive in vitro Models

2020

Hebeda CB, Sandri S, Benis CM, Paula-Silva MD, Loiola RA, Reutelingsperger C, Perretti M and Farsky SHP (2020). Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst. Cells  vol. 9, (5) 10.3390/cells9051188

Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C and Bombardieri M (2020). H and L chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity toward neutrophil extracellular trap antigens in rheumatoid arthritis synovial b cell clones. Journal of Immunology  vol. 204, (9) 2374-2379. 10.4049/jimmunol.1901457

Norling LV and Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of The National Academy of Sciences of The United States of America  vol. 117, (17) 9148-9150. 10.1073/pnas.2004241117

McArthur S, Juban G, Gobbetti T, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP, Chazaud B, Perretti M and Mounier R (2020). Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation. Journal of Clinical Investigation  vol. 130, (3) 1156-1167. 10.1172/JCI124635

Belvedere R, Pessolano E, Porta A, Tosco A, Parente L, Petrella F, Perretti M and Petrella A (2020). Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound healing. European Journal of Pharmacology  vol. 869, 10.1016/j.ejphar.2019.172894

Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media  Frontiers in Immunology  vol. 11, 10.3389/fimmu.2020.00010

Montero Melendez T, Nagano A, Chelala C, Filer A, Buckley CD and Perretti M (2020). Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis. Nature Research (Part of Springer Nature)  Nature Communications  vol. 11, (1) 10.1038/s41467-020-14421-x

Machado MG, Tavares LP, Souza GVS, Queiroz-Junior CM, Ascenção FR, Lopes ME, Garcia CC, Menezes GB, Perretti M, Russo RC, Teixeira MM and Sousa LP (2020). The Annexin A1/FPR2 pathway controls the inflammatory response and bacterial dissemination in experimental pneumococcal pneumonia. Faseb Journal  vol. 34, (2) 2749-2764. 10.1096/fj.201902172R

(2020). Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Brain, Behavior, and Immunity  10.1016/j.bbi.2020.02.015

2019

Barbosa CMV, Fock RA, Hastreiter AA, Reutelingsperger C, Perretti M, Paredes-Gamero EJ and Farsky SHP (2019). Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca²⁺/MAPK signalling transduction pathway. Cell Death Discovery  vol. 5, (1) 10.1038/s41420-019-0215-1

Bizzarro V, Belvedere R, Pessolano E, Parente L, Petrella F, Perretti M and Petrella A (2019). Mesoglycan induces keratinocyte activation by triggering syndecan-4 pathway and the formation of the annexin A1/S100A11 complex. Journal of Cellular Physiology  vol. 234, (11) 20174-20192. 10.1002/jcp.28618

Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P, Reutelingsperger CP, Naccache JM, Bonnotte B, Karras A, Puéchal X, Guillevin L, Terrier B, Frachet P, Perretti M, Mouthon L and Witko-Sarsat V (2019). Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance. Kidney International  vol. 96, (2) 397-408. 10.1016/j.kint.2019.02.017

Senchenkova EY, Ansari J, Becker F, Vital SA, Al-Yafeai Z, Sparkenbaugh EM, Pawlinski R, Stokes KY, Carroll JL, Dragoi AM, Qin CX, Ritchie RH, Sun H, Cuellar-Saenz HH, Rubinstein MR, Han YW, Orr AW, Perretti M, Granger DN and Gavins FNE (2019). Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation. Circulation  vol. 140, (4) 319-335. 10.1161/CIRCULATIONAHA.118.039345

Salamah MF, Ravishankar D, Vaiyapuri R, Moraes LA, Patel K, Perretti M, Gibbins JM and Vaiyapuri S (2019). The formyl peptide fMLF primes platelet activation and augments thrombus formation. Journal of Thrombosis and Haemostasis  vol. 17, (7) 1120-1133. 10.1111/jth.14466

Nadkarni S, Lashin H, Hollywood J, Dasgupta B, Mason JC and Perretti M (2019). Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: A potential involvement of immune cell cross-talk. Clinical Science  vol. 133, (7) 839-851. 10.1042/CS20180415

(2019). Formyl peptide receptor 1 signalling promotes experimental colitis in mice. Pharmacological Research  vol. 141, 591-601. 10.1016/j.phrs.2019.01.041

Sugimoto MA, Vago JP, Perretti M and Teixeira MM (2019). Mediators of the Resolution of the Inflammatory Response. Trends in Immunology  vol. 40, (3) 212-227. 10.1016/j.it.2019.01.007

de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C and Guiry PJ (2019). Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). European Journal of Medicinal Chemistry  vol. 162, 80-108. 10.1016/j.ejmech.2018.10.049

VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C, PERRETTI M and NOURSHARGH S (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. Wiley  Journal of Pathology  vol. 248, (1) 88-102. 10.1002/path.5234

Sinniah A, Yazid S, Bena S, Oliani SM, Perretti M and Flower RJ (2019). Endogenous annexin-A1 negatively regulates mast cell-mediated allergic reactions. Frontiers in Pharmacology  vol. 10, 10.3389/fphar.2019.01313

Vago JP, Sugimoto MA, Lima KM, Negreiros-Lima GL, Baik N, Teixeira MM, Perretti M, Parmer RJ, Miles LA and Sousa LP (2019). Plasminogen and the plasminogen receptor, PLG-RKT, regulate macrophage phenotypic, and functional changes. Frontiers in Immunology  vol. 10, (JUN) 10.3389/fimmu.2019.01458

2018

Thomas BL and Perretti M (2018). Neutrophil wrap. Nature Nanotechnology  vol. 13, (12) 1098-1099. 10.1038/s41565-018-0260-6

Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L, Perretti M and Petrella A (2018). Annexin A1 may induce pancreatic cancer progression as a key player of extracellular vesicles effects as evidenced in the in vitro MIA PaCa-2 model system. International Journal of Molecular Sciences  vol. 19, (12) 10.3390/ijms19123878

Petri MH, Thul S, Andonova T, Lindquist-Liljeqvist M, Jin H, Skenteris NT, Arnardottir H, Maegdefessel L, Caidahl K, Perretti M, Roy J and Bäck M (2018). Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms. Jacc: Basic to Translational Science  vol. 3, (6) 719-727. 10.1016/j.jacbts.2018.08.005

Salamah MF, Ravishankar D, Kodji X, Moraes LA, Williams HF, Vallance TM, Albadawi DA, Vaiyapuri R, Watson K, Gibbins JM, Brain SD, Perretti M and Vaiyapuri S (2018). The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation. Blood Advances  vol. 2, (21) 2973-2985. 10.1182/bloodadvances.2018021758

Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K, Aronica E, Porcu L, Pistorius K, Colas RA, Hansen TV, Perretti M, Kaminski RM, Dalli J and Vezzani A (2018). n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain  vol. 141, (11) 3130-3143. 10.1093/brain/awy247

Hebeda CB, Machado ID, Reif-Silva I, Moreli JB, Oliani SM, Nadkarni S, Perretti M, Bevilacqua E and Farsky SHP (2018). Endogenous annexin A1 (AnxA1) modulates early-phase gestation and offspring sex-ratio skewing. Journal of Cellular Physiology  vol. 233, (9) 6591-6603. 10.1002/jcp.26258

Patruno S, Garrido-Mesa J, Romano M, PERRETTI M and MONTERO MELENDEZ T (2018). Ligand bias and its association with pro-resolving actions of melanocortin drugs. Frontiers Media  Frontiers in Pharmacology  vol. 9, (919) 10.3389/fphar.2018.00919

PITZALIS C, CORSIERO E, JAGEMANN L, PERRETTI M and BOMBARDIERI M (2018). Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints. American Association of Immunologists  Journal of Immunology  10.4049/jimmunol.1800346

Piovezan AP and Perretti M (2018). Potential engagement of pathways of the resolution of inflammation as mechanism of action for plants on animal models. Journal of Ethnopharmacology  vol. 221, 160-161. 10.1016/j.jep.2017.11.033

Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF, Perretti M, Murphy AJ, Du XJ, Gao XM and Ritchie RH (2018). Erratum: Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo (Scientific reports (2017) 7 1 (16615)). Scientific Reports  vol. 8, (1) 10.1038/s41598-018-24994-9

Lashin HMS, Nadkarni S, Oggero S, Jones HR, Knight JC, Hinds CJ and Perretti M (2018). Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis. Shock  vol. 49, (4) 393-401. 10.1097/SHK.0000000000000989

(2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Ebiomedicine  vol. 29, 60-69. 10.1016/j.ebiom.2018.02.003

Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S and Panigrahy D (2018). Resolvins suppress tumor growth and enhance cancer therapy. Journal of Experimental Medicine  vol. 215, (1) 115-140. 10.1084/jem.20170681

2017

Perretti M and Norling LV (2017). Actions of SPM in regulating host responses in arthritis. Molecular Aspects of Medicine  vol. 58, 57-64. 10.1016/j.mam.2017.04.005

Qin CX, Finlayson SB, Ai-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF, Perretti M, Murphy AJ, Du X-J, Gao X-M and Ritchie RH (2017). Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo. Macmillan Publishers Limited, Part of Springer Nature  Sci Rep  vol. 7, (1) 16615-16615. 10.1038/s41598-017-16317-1

Simeoli R, Montague K, Jones HR, Castaldi L, Chambers D, Kelleher JH, Vacca V, Pitcher T, Grist J, Al-Ahdal H, Wong L-F, Perretti M, Lai J, Mouritzen P, Heppenstall P and Malcangio M (2017). Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma. Macmillan Publishers Limited, Part of Springer Nature  Nat Commun  vol. 8, (1) 1778-1778. 10.1038/s41467-017-01841-5

Petri MH, Laguna-Fernandez A, Arnardottir H, Wheelock CE, Perretti M, Hansson GK and Bäck M (2017). Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E^−/− mice. British Journal of Pharmacology  vol. 174, (22) 4043-4054. 10.1111/bph.13707

Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF, Galvão I, Costa BRC, Soriani FM, Pinho V, Solito E, Perretti M, Teixeira MM and Sousa LP (2017). The resolution of acute inflammation induced by cyclic AMP is dependent on Annexin A1. Journal of Biological Chemistry  vol. 292, (33) 13758-13773. 10.1074/jbc.M117.800391

Perretti M and Montero-Melendez T (2017). Resolution in an 'over-inflamed' era. Biochemist  vol. 39, (4) 4-7. 10.1042/bio03904004

Gittens BR, Bodkin JV, Nourshargh S, Perretti M and Cooper D (2017). Galectin-3: A positive regulator of leukocyte recruitment in the inflamed microcirculation. Journal of Immunology  vol. 198, (11) 4458-4469. 10.4049/jimmunol.1600709

Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Journal of Ethnopharmacology  vol. 204, 179-188. 10.1016/j.jep.2017.03.059

(2017). Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide. Public Library of Science  Plos One  vol. 12, (4) e0175786-e0175786. 10.1371/journal.pone.0175786

(2017). The impact of environmental enrichment on the murine inflammatory immune response. Jci Insight  vol. 2, (7) 10.1172/jci.insight.90723

Montero-Melendez T, Forfar RAE, Cook JM, Jerman JC, Taylor DL and Perretti M (2017). Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cellular and Molecular Life Sciences  vol. 74, (7) 1335-1345. 10.1007/s00018-016-2419-3

Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and Perretti M (2017). Identification of novel chondroprotective mediators in resolving inflammatory exudates. Journal of Immunology  vol. 198, (7) 2876-2885. 10.4049/jimmunol.1601111

PERRETTI M, Dalli J, Colas R, Federici Canova D and Gobbetti T (2017). Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 114, (15) 3963-3968. 10.1073/pnas.1617290114

Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol  vol. 13, (2) 87-99. 10.1038/nrrheum.2016.193

Simeoli R, Mattace Raso G, Pirozzi C, Lama A, Santoro A, Russo R, Montero-Melendez T, Berni Canani R, Calignano A, Perretti M and Meli R (2017). An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis. British Journal of Pharmacology  vol. 174, (11) 1484-1496. 10.1111/bph.13637

2016

NADKARNI SA, Smith J, Mauro C, Marelli-Berg FM, Perretti M, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Williams DJ and Farsky S (2016). Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy., Editors: Medzhitov R. National Academy of Sciences  Proceedings of The National Academy of Sciences of Usa  10.1073/pnas.1611944114

Machado ID, Spatti M, Hastreiter A, Santin JR, Fock RA, Gil CD, Oliani SM, Perretti M and Farsky SHP (2016). Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway. Journal of Cellular Physiology  vol. 231, (11) 2418-2427. 10.1002/jcp.25346

Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists  Journal of Immunology  vol. 197, (6) 2362-2368. 10.4049/jimmunol.1502268

Madeira MFM, Queiroz-Junior CM, Montero-Melendez T, Werneck SMC, Correa JD, Soriani FM, Garlet GP, Souza DG, Teixeira MM, Silva TA and Perretti M (2016). Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection. Federation of American Society of Experimental Biology (Faseb)  The Faseb Journal  10.1096/fj.201600790R

(2016). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Annals of The Rheumatic Diseases  vol. 75, (6) 1228-1235. 10.1136/annrheumdis-2015-207316

Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology  Journal of The American Society of Nephrology  10.1681/ASN.2015060670

Vital SA, Becker F, Holloway PM, Russell J, Perretti M, Granger DN and Gavins FNE (2016). Fpr2/ALX Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease. American Heart Association  Circulation  10.1161/CIRCULATIONAHA.115.020633

Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T, Perretti M, Papapetropoulos A, Bucci M and Cirino G (2016). D -Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase. British Journal of Pharmacology  vol. 173, (9) 1556-1565. 10.1111/bph.13459

Sugimoto MA, Sousa LP, Pinho V, Perretti M and Teixeira MM (2016). Resolution of Inflammation: What Controls Its Onset? Frontiers Media  Frontiers in Immunology  vol. 7, 10.3389/fimmu.2016.00160

Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. Jci Insight  vol. 1, (5) 10.1172/jci.insight.85922

Jones HR, Robb CT, Perretti M and Rossi AG (2016). The role of neutrophils in inflammation resolution. Seminars in Immunology  vol. 28, (2) 137-145. 10.1016/j.smim.2016.03.007

Sinniah A, Yazid S, Perretti M, Solito E and Flower RJ (2016). The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. International Immunopharmacology  vol. 32, 87-95. 10.1016/j.intimp.2016.01.003

Vago JP, Tavares LP, Sugimoto MA, Lima GLN, Galvaõ I, De Caux TR, Ia L, Ribeiro ALC, Carneiro FS, Nunes FFC, Pinho V, Perretti M, Teixeira MM and Sousa LP (2016). Proresolving actions of synthetic and natural protease inhibitors are mediated by annexin A1. Journal of Immunology  vol. 196, (4) 1922-1932. 10.4049/jimmunol.1500886

(2016). Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Mediators of Inflammation  vol. 2016, 10.1155/2016/7368389

2015

(2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Science Translational Medicine  vol. 7, (315) 10.1126/scitranslmed.aac5608

Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Journal of Controlled Release  vol. 217, 284-292. 10.1016/j.jconrel.2015.09.021

Perretti M, Leroy X, Bland EJ and Montero-Melendez T (2015). Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation. Trends in Pharmacological Sciences  vol. 36, (11) 737-755. 10.1016/j.tips.2015.07.007

Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ and Gavins FNE (2015). Both MC1 and MC3 receptors provide protection from cerebral ischemia-reperfusion-induced neutrophil recruitment. Arteriosclerosis, Thrombosis, and Vascular Biology  vol. 35, (9) 1936-1944. 10.1161/ATVBAHA.115.305348

Kusters DHM, Chatrou ML, Willems BAG, De Saint-Hubert M, Bauwens M, Van Der Vorst E, Bena S, Biessen EAL, Perretti M, Schurgers LJ and Reutelingsperger CPM (2015). Pharmacological treatment with annexin A1 reduces atherosclerotic plaque burden in LDLR^-/- mice on Western Type Diet. Plos One  vol. 10, (6) 10.1371/journal.pone.0130484

Trentin PG, Ferreira TPT, Arantes ACS, Ciambarella BT, Cordeiro RSB, Flower RJ, Perretti M, Martins MA and Silva PMR (2015). Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice. British Journal of Pharmacology  vol. 172, (12) 3058-3071. 10.1111/bph.13109

Amoruso A, Fresu LG, Dalli J, Miglietta D, Bardelli C, Canova DF, Perretti M and Brunelleschi S (2015). Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen. Life Sciences  vol. 126, 28-36. 10.1016/j.lfs.2015.01.025

Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TE and Perretti M (2015). Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. The American Association of Immunologists, Inc.  J Immunol  vol. 194, (7) 3381-3388. 10.4049/jimmunol.1402645

Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N and Cenac N (2015). Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. Br J Pharmacol  vol. 172, (3) 910-923. 10.1111/bph.12957

Flower RJ and Perretti M (2015). 'Annexins' themed section. British Journal of Pharmacology  vol. 172, (7) 1651-1652. 10.1111/bph.13089

Petri MH, Laguna-Fernandez A, Tseng CN, Hedin U, Perretti M and Bäck M (2015). Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation. International Journal of Cardiology  vol. 179, 370-372. 10.1016/j.ijcard.2014.11.010

Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M, Farokzhad O and Tabas I (2015). Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Science Translational Medicine  vol. 7, (275) 10.1126/scitranslmed.aaa1065

Leoni G, Neumann PA, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS and Nusrat A (2015). Annexin A1'containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. Journal of Clinical Investigation  vol. 125, (3) 1215-1227. 10.1172/JCI76693

Perretti M (2015). The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology. Seminars in Immunology  vol. 27, (3) 145-148. 10.1016/j.smim.2015.06.001

McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ and Perretti M (2015). Definition of a novel pathway centered on lysophosphatidic acid to recruit monocytes during the resolution phase of tissue inflammation. Journal of Immunology  vol. 195, (3) 1139-1151. 10.4049/jimmunol.1500733

Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D Acquisto F, Bland EJ, Bombardieri M, Pitzalis C, Perretti M, Marelli-Berg FM and Mauro C (2015). Lactate regulates metabolic and proinflammatory circuits in control of T cell migration and effector functions. Plos Biology  vol. 13, (7) 10.1371/journal.pbio.1002202

2014

Gobbetti T, Coldewey SM, Chen J, McArthur S, Le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of The National Academy of Sciences of The United States of America  vol. 111, (52) 18685-18690. 10.1073/pnas.1410938111

Thompson D, McArthur S, Hislop JN, Flower RJ and Perretti M (2014). Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: association with cell protection from apoptosis. J Biol Chem  vol. 289, (52) 36166-36178. 10.1074/jbc.M114.612630

(2014). Formyl peptide receptor as a novel therapeutic target for anxiety-related disorders. Plos One  vol. 9, (12) 10.1371/journal.pone.0114626

Machado ID, Santin JR, Drewes CC, Gil CD, Oliani SM, Perretti M and Farsky SHP (2014). Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions. Am J Physiol Endocrinol Metab  vol. 307, (9) E754-E763. 10.1152/ajpendo.00227.2014

Brancaleone V, Mitidieri E, Flower RJ, Cirino G and Perretti M (2014). Annexin A1 mediates hydrogen sulfide properties in the control of inflammation. J Pharmacol Exp Ther  vol. 351, (1) 96-104. 10.1124/jpet.114.217034

(2014). Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol  vol. 91, (3) 348-358. 10.1016/j.bcp.2014.07.034

Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine  vol. 18, (10) 2117-2124. 10.1111/jcmm.12374

Montero-Melendez T and Perretti M (2014). Gapdh gene expression is modulated by inflammatory arthritis and is not suitable for qPCR normalization. Inflammation  vol. 37, (4) 1059-1069. 10.1007/s10753-014-9829-x

Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D and Perretti M (2014). Resolution of inflammation: examples of peptidergic players and pathways. Drug Discov Today  vol. 19, (8) 1166-1171. 10.1016/j.drudis.2014.05.020

Cash JL, Norling LV and Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today  vol. 19, (8) 1186-1192. 10.1016/j.drudis.2014.06.023

Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol  vol. 184, (8) 2333-2341. 10.1016/j.ajpath.2014.04.009

Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S, Parola M, Paternostro C, Bugianesi E, McArthur S, Albano E and Perretti M (2014). Endogenous Annexin A1 Is a Novel Protective Determinant in Nonalcoholic Steatohepatitis in Mice. Hepatology  vol. 60, (2) 531-544. 10.1002/hep.27141

Montero-Melendez T and Perretti M (2014). Connections in pharmacology: innovation serving translational medicine. Drug Discov Today  vol. 19, (7) 820-823. 10.1016/j.drudis.2013.11.022

(2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep  vol. 4, 10.1038/srep05237

Old EA, Nadkarni S, Grist J, Gentry C, Bevan S, Kim K-W, Mogg AJ, Perretti M and Malcangio M (2014). Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. Journal of Clinical Investigation  vol. 124, (5) 2023-2036. 10.1172/JCI71389

Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ, Cooper D, Perretti M and Marelli-Berg FM (2014). Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun  vol. 5, 10.1038/ncomms4436

Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B and Perretti M (2014). Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression. Circ Res  vol. 114, (2) 242-248. 10.1161/CIRCRESAHA.114.301374

Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. Embo Mol Med  vol. 6, (1) 27-42. 10.1002/emmm.201303503

2013

Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ and Perretti M (2013). Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A  vol. 110, (45) 18232-18237. 10.1073/pnas.1308253110

Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V and Perretti M (2013). Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. Embo Rep  vol. 14, (11) 999-1007. 10.1038/embor.2013.138

(2013). Annexin-A1 Peptide Ac2-26. Handbook of Biologically Active Peptides  10.1016/B978-0-12-385095-9.00086-5

Godson C and Perretti M (2013). Novel pathways in the yin-yang of immunomodulation. Current Opinion in Pharmacology  vol. 13, (4) 543-546. 10.1016/j.coph.2013.06.010

Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics  vol. 12, (8) 2205-2219. 10.1074/mcp.M113.028589

Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S and Perretti M (2013). A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood  vol. 122, (4) 608-617. 10.1182/blood-2013-04-496661

Iqbal AJ, Cooper D, Vugler A, Gittens BR, Moore A and Perretti M (2013). Endogenous galectin-1 exerts tonic inhibition on experimental arthritis. J Immunol  vol. 191, (1) 171-177. 10.4049/jimmunol.1203291

(2013). Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor. J Immunol  vol. 190, (12) 6478-6487. 10.4049/jimmunol.1203000

Norling LV and Perretti M (2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol  vol. 13, (3) 476-481. 10.1016/j.coph.2013.02.003

Ortega-Gomez A, Perretti M and Soehnlein O (2013). Resolution of inflammation: an integrated view. Embo Molecular Medicine  vol. 5, (5) 661-674. 10.1002/emmm.201202382

Fowkes RC, Moradi-Bidhendi N, Branceleone V, Zariwala MG, Brady D, Jessop DS, Perretti M and Renshaw D (2013). Annexin-A1 protein and its relationship to cortisol in human saliva. Psychoneuroendocrinology  vol. 38, (5) 722-727. 10.1016/j.psyneuen.2012.08.003

Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI and Brayden DJ (2013). An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis. J Control Release  vol. 167, (2) 120-129. 10.1016/j.jconrel.2013.01.027

Montero-Melendez T, Dalli J and Perretti M (2013). Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. Cell Death Differ  vol. 20, (4) 567-575. 10.1038/cdd.2012.154

Rhodes DH, Pini M, Castellanos KJ, Montero-Melendez T, Cooper D, Perretti M and Fantuzzi G (2013). Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function. Obesity (Silver Spring)  vol. 21, (2) 310-319. 10.1002/oby.20016

Schutters K, Kusters DHM, Chatrou MLL, Montero-Melendez T, Donners M, Deckers NM, Krysko DV, Vandenabeele P, Perretti M, Schurgers LJ and Reutelingsperger CPM (2013). Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death Differ  vol. 20, (1) 49-56. 10.1038/cdd.2012.107

Kosicka A, Cunliffe AD, Mackenzie R, Zariwala MG, Perretti M, Flower RJ and Renshaw D (2013). Attenuation of plasma annexin A1 in human obesity. Faseb Journal  vol. 27, (1) 368-378. 10.1096/fj.12-213728

Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N and Perretti M (2013). The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis. Plos One  vol. 8, (2) 10.1371/journal.pone.0054299

Norling LV and Perretti M (2013). Control of myeloid cell trafficking in resolution. J Innate Immun  vol. 5, (4) 367-376. 10.1159/000350612

Ahmed TJ, Montero-Melendez T, Perretti M and Pitzalis C (2013). Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides. Int J Inflam  vol. 2013, 10.1155/2013/985815

Leoni G, Alam A, Neumann P-A, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K, Murthy N, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Neish AS and Nusrat A (2013). Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. Journal of Clinical Investigation  vol. 123, (1) 443-454. 10.1172/JCI65831

Pang J, Rhodes DH, Pini M, Akasheh RT, Castellanos KJ, Cabay RJ, Cooper D, Perretti M and Fantuzzi G (2013). Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. Plos One  vol. 8, (2) 10.1371/journal.pone.0057915

Viiri LE, Full LE, Navin TJ, Begum S, Didangelos A, Astola N, Berge RK, Seppala I, Shalhoub J, Franklin IJ, Perretti M, Lehtimaki T, Davies AH, Wait R and Monaco C (2013). Smooth muscle cells in human atherosclerosis: Proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease. Journal of Molecular and Cellular Cardiology  vol. 54, 65-72. 10.1016/j.yjmcc.2012.11.002

(2013). Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression. Mediators Inflamm  vol. 2013, 10.1155/2013/741804

Montero-Meléndez T, Llor X, García-Planella E, Perretti M and Suárez A (2013). Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling. Plos One  vol. 8, (10) 10.1371/journal.pone.0076235

2012

(2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Ann Rheum Dis  vol. 71, (11) 1872-1880. 10.1136/annrheumdis-2011-201180

Cardini S, Dalli J, Fineschi S, Perretti M, Lungarella G and Lucattelli M (2012). Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice. American Journal of Respiratory Cell and Molecular Biology  vol. 47, (3) 332-339. 10.1165/rcmb.2012-0036OC

Perretti M (2012). Editorial: to resolve or not to resolve: annexin A1 pushes resolution on track. J Leukoc Biol  vol. 92, (2) 245-247. 10.1189/jlb.0312128

Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol  vol. 32, (8) 1970-1978. 10.1161/ATVBAHA.112.249508

Bena S, Brancaleone V, Wang JM, Perretti M and Flower RJ (2012). Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling. J Biol Chem  vol. 287, (29) 24690-24697. 10.1074/jbc.M112.377101

(2012). Distinct localization of T cell Agrin during antigen presentation--evidence for the expression of Agrin receptor(s) in antigen-presenting cells. Febs J  vol. 279, (13) 2368-2380. 10.1111/j.1742-4658.2012.08615.x

Vong L, Ferraz JGP, Dufton N, Panaccione R, Beck PL, Sherman PM, Perretti M and Wallace JL (2012). Up-Regulation of Annexin-A1 and Lipoxin A(4) in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis. Plos One  vol. 7, (6) 10.1371/journal.pone.0039244

Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and Balkwill FR (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol  vol. 227, (2) 136-145. 10.1002/path.4002

Clark AK, Grist J, Al-Kashi A, Perretti M and Malcangio M (2012). Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model. Arthritis and Rheumatism  vol. 64, (6) 2038-2047. 10.1002/art.34351

Liverani E, Banerjee S, Roberts W, Naseem KM and Perretti M (2012). Prednisolone exerts exquisite inhibitory properties on platelet functions. Biochem Pharmacol  vol. 83, (10) 1364-1373. 10.1016/j.bcp.2012.02.006

(2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Annals of The Rheumatic Diseases  10.1136/annrheumdis-2011-201180

Cooper D, Iqbal AJ, Gittens BR, Cervone C and Perretti M (2012). The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? Ann N Y Acad Sci  vol. 1253, 181-192. 10.1111/j.1749-6632.2011.06291.x

Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD, Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML and Nourshargh S (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves. Faseb J  vol. 26, (3) 1064-1076. 10.1096/fj.11-196220

(2012). Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn-Schmiedebergs Archives of Pharmacology  vol. 385, (2) 137-144. 10.1007/s00210-011-0703-1

de Lima CB, Tamura EK, Montero-Melendez T, Palermo-Neto J, Perretti M, Markus RP and Farsky SHP (2012). Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling. Biochem Biophys Res Commun  vol. 417, (2) 918-923. 10.1016/j.bbrc.2011.12.078

Dalli J, Jones CP, Cavalcanti DM, Farsky SH, Perretti M and Rankin SM (2012). Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. Faseb J  vol. 26, (1) 387-396. 10.1096/fj.11-182089

Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed M, Perretti M and Chernajovsky Y (2012). Molecular engineering of short half-life small peptides (VIP, αMSH and γ₃MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics. Ann Rheum Dis  vol. 71, (1) 143-149. 10.1136/annrheumdis-2011-200100

Dalli J, Montero-Melendez T, McArthur S and Perretti M (2012). Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol  vol. 3, 10.3389/fphar.2012.00028

(2012). Mapping pathogenesis of arthritis through small animal models. Rheumatology (United Kingdom)  vol. 51, (11) 1931-1941. 10.1093/rheumatology/kes035

2011

(2011). High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents. Biochem Pharmacol  vol. 82, (12) 1919-1929. 10.1016/j.bcp.2011.09.009

Nadkarni S, Cooper D, Brancaleone V, Bena S and Perretti M (2011). Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes. Arterioscler Thromb Vasc Biol  vol. 31, (11) 2749-2759. 10.1161/ATVBAHA.111.235176

Damazo AS, Sampaio AL, Nakata CM, Flower RJ, Perretti M and Oliani SM (2011). Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis. Bmc Immunol  vol. 12, 10.1186/1471-2172-12-59

Patel HB, Montero-Melendez T, Greco KV and Perretti M (2011). Melanocortin receptors as novel effectors of macrophage responses in inflammation., Editors: Ariel A. Frontiers in Immunology  vol. 2, 1-6. 10.3389/fimmu.2011.00041

Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TEN and Perretti M (2011). The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties. Am J Pathol  vol. 179, (1) 259-269. 10.1016/j.ajpath.2011.03.042

(2011). Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. J Pharmacol Exp Ther  vol. 337, (3) 830-837. 10.1124/jpet.111.179168

(2011). IL-17A increases ADP-induced platelet aggregation. Biochem Biophys Res Commun  vol. 408, (4) 658-662. 10.1016/j.bbrc.2011.04.080

Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. Journal of Immunology  vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865

Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J Immunol  vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865

Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ and Ahluwalia A (2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol  vol. 31, (5) 1075-1083. 10.1161/ATVBAHA.111.223545

Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G and Perretti M (2011). Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol  vol. 186, (8) 4905-4914. 10.4049/jimmunol.1003145

Montero-Melendez T, Patel HB and Perretti M (2011). Role of melanocortin receptors in the regulation of gouty inflammation. Curr Rheumatol Rep  vol. 13, (2) 138-145. 10.1007/s11926-011-0163-0

Iqbal AJ, Sampaio ALF, Maione F, Greco KV, Niki T, Hirashima M, Perretti M and Cooper D (2011). Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. Am J Pathol  vol. 178, (3) 1201-1209. 10.1016/j.ajpath.2010.11.073

Gavins FNE, Li G, Russell J, Perretti M and Granger DN (2011). Microvascular thrombosis and CD40/CD40L signaling. J Thromb Haemost  vol. 9, (3) 574-581. 10.1111/j.1538-7836.2010.04176.x

(2011). Anti-inflammatory role of the murine formyl-peptide receptor 2: Ligand-specific effects on leukocyte responses and experimental in-flammation (The Journal of Immunology (2010) 184, (2611-2619)). Journal of Immunology  vol. 186, (4) 2684-2685. 10.4049/jimmunol.1090139

(2011). Cross-talk between minimally primed HL-60 cells and resting HUVEC reveals a crucial role for adhesion over extracellularly released oxidants. Biochem Pharmacol  vol. 81, (3) 396-401. 10.1016/j.bcp.2010.10.018

Colucci M, Mastriota M, Maione F, Di Giannuario A, Mascolo N, Palmery M, Severini C, Perretti M and Pieretti S (2011). Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids. Peptides  vol. 32, (2) 266-271. 10.1016/j.peptides.2010.11.019

Patel HB, Montero-Melendez T, Greco KV and Perretti M (2011). Melanocortin receptors as novel effectors of macrophage responses in inflammation. Front Immunol  vol. 2, 10.3389/fimmu.2011.00041

(2011). An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse. Lab Invest  vol. 91, (1) 33-42. 10.1038/labinvest.2010.140

2010

(2010). Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells. Autoimmunity  vol. 43, (8) 672-681. 10.3109/08916931003678296

(2010). Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. Faseb J  vol. 24, (12) 4835-4843. 10.1096/fj.10-167759

Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med  vol. 26, (6) 913-918. 10.3892/ijmm_00000542

Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med  vol. 26, (6) 913-918. 10.3892/ijmm_00000542

(2010). Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature. Blood  vol. 116, (20) 4288-4296. 10.1182/blood-2010-02-270520

Maderna P, Cottell DC, Toivonen T, Dufton N, Dalli J, Perretti M and Godson C (2010). FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. Faseb J  vol. 24, (11) 4240-4249. 10.1096/fj.10-159913

(2010). Downstream gene activation of the receptor ALX by the agonist annexin A1. Plos One  vol. 5, (9) 10.1371/journal.pone.0012771

Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M and Flower RJ (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol  vol. 30, (9) 1718-1724. 10.1161/ATVBAHA.110.209536

Dufton N and Perretti M (2010). Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists. Pharmacol Ther  vol. 127, (2) 175-188. 10.1016/j.pharmthera.2010.04.010

Dalli J, Rosignoli G, Hayhoe RPG, Edelman A and Perretti M (2010). CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway. Am J Pathol  vol. 177, (1) 176-186. 10.2353/ajpath.2010.091149

Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF and Perretti M (2010). Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. J Leukoc Biol  vol. 87, (5) 877-884. 10.1189/jlb.1009670

Leoni G, Voisin M-B, Carlson K, Getting S, Nourshargh S and Perretti M (2010). The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. Br J Pharmacol  vol. 160, (1) 171-180. 10.1111/j.1476-5381.2010.00688.x

Semple F, Webb S, Li HN, Patel HB, Perretti M, Jackson IJ, Gray M, Davidson DJ and Dorin JR (2010). Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. Eur J Immunol  vol. 40, (4) 1073-1078. 10.1002/eji.200940041

(2010). Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J Immunol  vol. 184, (5) 2611-2619. 10.4049/jimmunol.0903526

Sarndahl E, Bergstrom I, Nijm J, Forslund T, Perretti M and Jonasson L (2010). Enhanced neutrophil expression of annexin-1 in coronary artery disease. Metabolism  vol. 59, (3) 433-440. 10.1016/j.metabol.2009.07.044

(2010). Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. Cell Cycle  vol. 9, (4) 785-794. 10.4161/cc.9.4.10673

Patel HB, Leoni G, Melendez TM, Sampaio ALF and Perretti M (2010). Melanocortin Control of Cell Trafficking in Vascular Inflammation. 10.1007/978-1-4419-6354-3_7

Hunter C, Kadakia TB, Cooper D, Perretti M, Schwartz RC and Brown SB (2010). Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands. Thescientificworldjournal  vol. 10, 1580-1596. 10.1100/tsw.2010.155

Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. International Journal of Molecular Medicine  vol. 26, (6) 913-918. 10.3892/ijmm_00000542

(2010). The Cardio-Protective Properties of Ncx-6550, a Nitric Oxide Donating Pravastatin, in the Mouse. Microcirculation  vol. 17, (6) 417-426. 10.1111/j.1549-8719.2010.00040.x

Cooper D, Ilarregui JM, Pesoa SA, Croci DO, Perretti M and Rabinovich GA (2010). Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate. 10.1016/S0076-6879(10)80011-4

(2010). Comparative analysis of Annexin A1-Formyl Peptide Receptor 2/ALX expression in human leukocyte subsets. Elsevier  International Immunopharmacology  vol. 11, (1) 55-66. 10.1016/j.intimp.2010.10.006

2009

(2009). Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1. J Neuroinflammation  vol. 6, 10.1186/1742-2094-6-33

Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P, Marrelli A, Pitzalis C, Cipollone F, Schanstra J, Bascands J-L, Hobbs AJ, Perretti M and Ahluwalia A (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol  vol. 29, (11) 1757-1763. 10.1161/ATVBAHA.109.191775

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature  vol. 461, (7268) 1287-U125. 10.1038/nature08541

Perretti M and Dalli J (2009). Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics. Br J Pharmacol  vol. 158, (4) 936-946. 10.1111/j.1476-5381.2009.00483.x

McColl A, Bournazos S, Franz S, Perretti M, Morgan BP, Haslett C and Dransfield I (2009). Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages. J Immunol  vol. 183, (3) 2167-2175. 10.4049/jimmunol.0803503

Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukocyte Biol  vol. 86, (1) 115-122. 10.1189/JLB.0508284

Norling LV, Perretti M and Cooper D (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol  vol. 201, (2) 169-184. 10.1677/JOE-08-0512

Patel HB, Bombardieri M, Pitzalis C and Perretti M (2009). Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis. Eur J Clin Invest  vol. 39, 29-29.

(2009). The impact of Annexin-A1 cleavage on neutrophil behaviour during vascular inflammation. Eur J Clin Invest  vol. 39, 37-37.

(2009). Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. Faseb J  vol. 23, (4) 985-996. 10.1096/fj.08-119040

Tripatara P, Patel NSA, Brancaleone V, Renshaw D, Rocha J, Sepodes B, Mota-Filipe H, Perretti M and Thiemermann C (2009). Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. Eur J Pharmacol  vol. 606, (1-3) 205-209. 10.1016/j.ejphar.2009.01.041

(2009). Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol  vol. 77, (5) 878-887. 10.1016/j.bcp.2008.11.011

Hecht I, Rong J, Sampaio ALF, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, Cojocaru G, Zauberman A, Rotman G, Perretti M, Vinten-Johansen J and Cohen Y (2009). A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects. J Pharmacol Exp Ther  vol. 328, (2) 426-434. 10.1124/jpet.108.145821

Gastardelo TS, Damazo AS, Dalli J, Flower RJ, Perretti M and Oliani SM (2009). Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation. Am J Pathol  vol. 174, (1) 177-183. 10.2353/ajpath.2009.080342

(2009). Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol  vol. 9, (1) 62-70. 10.1038/nri2470

Dufton NP, Hannon R, Perretti M and Flower R (2009). Quantitative Analysis of Promoter Activity by Green Fluorescent Protein (GFP) Target/Reporter Strategy in a Novel Transgenic alx/fpr-rs2 Null Mouse. Inflammation Research  vol. 58, (2) S252-S255. 10.1007/BF03354231

2008

Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M and Spina D (2008). A role for MC3R in modulating lung inflammation. Pulm Pharmacol Ther  vol. 21, (6) 866-873. 10.1016/j.pupt.2008.09.004

Leoni G, Patel HB, Sampaio ALF, Gavins FNE, Murray JF, Grieco P, Getting SJ and Perretti M (2008). Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. Faseb J  vol. 22, (12) 4228-4238. 10.1096/fj.08-113886

Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ, Perretti M, Parkos CA and Nusrat A (2008). Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol  vol. 181, (7) 5035-5044. 10.4049/jimmunol.181.7.5035

Oliani SM, Ciocca GAP, Pimentel TA, Damazo AS, Gibbs L and Perretti M (2008). Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation. Inflamm Res  vol. 57, (10) 450-456. 10.1007/s00011-008-7222-7

Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood  vol. 112, (6) 2512-2519. 10.1182/blood-2008-02-140533

(2008). Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. Brit J Pharmacol  vol. 155, (2) 152-169. 10.1038/bjp.2008.252

(2008). Overview of the role of annexin 1 in the innate and adaptive immune response. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry  vol. 8, (3) 252-258. 10.2174/187152208785748313

Dufton N, Buckingham J, Perretti M and Flower R (2008). Initial characterisation of the novel transgenic, the alx/fpr-rs2 null mouse. Fund Clin Pharmacol  vol. 22, 48-48.

Cooper D, Norling LV and Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukocyte Biol  vol. 83, (6) 1459-1466. 10.1189/jlb.1207831

(2008). Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells. Rheumatology (Oxford)  vol. 47, (5) 636-639. 10.1093/rheumatology/ken062

Sarndahl E, Bergstrom I, Nijm J, Perretti M and Jonasson L (2008). ENHANCED NEUTROPHIL EXPRESSION OF ANNEXIN-1 IN CORONARY ARTERY DISEASE. Atherosclerosis Supp  vol. 9, (1) 15-15. 10.1016/S1567-5688(08)70055-2

Yona S, Lin HH, Dri P, Davies JQ, Hayhoe RPG, Lewis SM, Heinsbroek SEM, Brown KA, Perretti M, Hamann J, Treacher DF, Gordon S and Stacey M (2008). Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. Faseb J  vol. 22, (3) 741-751. 10.1096/fj.07-9435com

Martin GR, Perretti M, Flower RJ and Wallace JL (2008). Annexin-1 modulates repair of gastric mucosal injury. Am J Physiol-Gastr L  vol. 294, (3) G764-G769. 10.1152/ajpgi.00531.2007

Norling LV, Sampaio ALF, Cooper D and Perretti M (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. Faseb J  vol. 22, (3) 682-690. 10.1096/fj.07-9268com

2007

Finney SJ, Anning PB, Cao TV, Perretti M, Evans TW and Burke-Gaffney A (2007). Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion. Biochem Bioph Res Co  vol. 364, (4) 831-837. 10.1016/j.bbrc.2007.10.088

(2007). Aromatic lipoxin A(4) and lipoxin B-4 analogues display potent biological activities. J Med Chem  vol. 50, (24) 5894-5902. 10.1021/jm060270d

(2007). Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. Eur J Immunol  vol. 37, (11) 3131-3142. 10.1002/eji.200636792

(2007). Annexin 1 cleavage in activated neutrophils - A pivotal role for proteinase 3. J Biol Chem  vol. 282, (41) 29998-30004. 10.1074/jbc.M702876200

Perretti M and Mancini L (2007). Potential of calcitonin as a novel cotreatment for arthritis. Future Rheumatology  vol. 2, (5) 493-496. 10.2217/17460816.2.5.493

Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M and Ahluwalia A (2007). A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. J Immunol  vol. 179, (7) 4849-4856. 10.4049/jimmunol.179.7.4849

Gavins FNE, Dalli J, Flower RJ, Granger DN and Perretti M (2007). Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. Faseb J  vol. 21, (8) 1751-1758. 10.1096/fj.06-7842com

Urquhart P, Rosignoli G, Cooper D, Motterlini R and Perretti M (2007). Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow. J Pharmacol Exp Ther  vol. 321, (2) 656-662. 10.1124/jpet.106.117218

John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E and Buckingham JC (2007). Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. Faseb J  vol. 21, (4) 1037-1046. 10.1096/fj.06-7299com

Giner RM, Mancini L, Kamal AM and Perretti M (2007). Uneven modulation of the annexin 1 system in osteoblast-like cells by dexamethasone. Biochem Bioph Res Co  vol. 354, (2) 414-419. 10.1016/j.bbrc.2006.12.224

Mancini L, Paul-Clark MJ, Rosignoli G, Hannon R, Martin JE, Macintyre I and Perretti M (2007). Calcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritis. Am J Pathol  vol. 170, (3) 1018-1027. 10.2353/ajpath.2007.060830

Perretti M (2007). Glucocorticoids in innate immunity: more transactivation than transrepression! Blood  vol. 109, (3) 852-853. 10.1182/blood-2006-11-056853

(2007). Resolution of inflammation: state of the art, definitions and terms. Faseb J  vol. 21, (2) 325-332. 10.1096/fj.06-7227rev

(2007). Annexin-1 modulates T-cell activation and differentiation. Blood  vol. 109, (3) 1095-1102. 10.1182/blood-2006-05-022798

2006

Getting SJ, Lam CW, Leoni G, Gavins FNE, Grieco P and Perretti M (2006). [D-Trp(8)]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol Pharmacol  vol. 70, (6) 1850-1855. 10.1124/mol.106.028878

Sawmynaden P and Perretti M (2006). Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes. Biochem Biophys Res Commun  vol. 349, (4) 1351-1355. 10.1016/j.bbrc.2006.08.179

Getting SJ, Lam CW, Chen AS, Grieco P and Perretti M (2006). Melanocortin 3 receptors control crystal-induced inflammation. Faseb J  vol. 20, (13) 2234-2241. 10.1096/fj.06-6339com

Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E and Perretti M (2006). Antiflammin-2 activates the human formyl-peptide receptor like 1. Scientificworldjournal  vol. 6, 1375-1384. 10.1100/tsw.2006.247

Flower RJ, Ayoub S and Perretti M (2006). Anti-inflammatory and analgesic aspects of the annexin A1 system. Acta Pharmacol Sin  vol. 27, (9) 1272-1272.

Cassatella MA and Perretti M (2006). Immunomodulation. The promises of immunopharmacology for the development of new drugs. Current Opinion in Pharmacology  vol. 6, (4) 376-378. 10.1016/j.coph.2006.04.003

(2006). Annexin 1, anti-inflammatory drugs and the neuroendocrine-immune interface. Acta Pharmacol Sin  vol. 27, 13-14.

Yona S, Heinsbroek SEM, Peiser L, Gordon S, Perretti M and Flower RJ (2006). Impaired phagocytic mechanism in annexin 1 null macrophages. Brit J Pharmacol  vol. 148, (4) 469-477. 10.1038/sj.bjp.0706730

(2006). Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptor. Inflamm Allergy Drug Targets  vol. 5, (2) 107-114. 10.2174/187152806776383170

Gil CD, La M, Perretti M and Oliani SM (2006). Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. Cell Biol Int  vol. 30, (4) 338-344. 10.1016/j.cellbi.2005.12.010

Damazo AS, Yona S, Flower RJ, Perretti M and Oliani SM (2006). Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J Immunol  vol. 176, (7) 4410-4418. 10.4049/jimmunol.176.7.4410

Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D and Perretti M (2006). Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood  vol. 107, (5) 2123-2130. 10.1182/blood-2005-08-3099

(2006). The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. Eur J Pharmacol  vol. 532, (1-2) 138-144. 10.1016/j.ejphar.2005.12.023

Lam CW, Perretti M and Getting SJ (2006). Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides  vol. 27, (2) 404-412. 10.1016/j.peptides.2005.01.031

Perretti M, COOPER D, Gil CD, Oliani SM and Rosignoli G (2006). Inflammation-induced modulation of cellular galectin-1 and –3 expression in a model of rat peritonitis. Inflammation Research  vol. 55, (3) 99-107. 10.1007/s00011-005-0059-4

Renshaw D, Urquhart P and Perretti M (2006). Therapeutic exploitation of endogenous anti-inflammatory mechanisms: Old and new leads. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry  vol. 5, (4) 289-305. 10.2174/187152306778772838

PERRETTI M, Nusrat A, Akyildiz A, Parkos CA, Babbin BA, Lee WY and Winfree LM (2006). Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem  vol. 281, 19588-19599. 10.1074/jbc.M513025200

2005

Moraes LA, Paul-Clark MJ, Rickman A, Flower RJ, Goulding NJ and Perretti M (2005). Ligand-specific glucocorticoid receptor activation in human platelets. Blood  vol. 106, (13) 4167-4175. 10.1182/blood-2005-04-1723

Bensalem N, Ventura AP, Vallee B, Lipecka J, Tondelier D, Davezac N, Dos Santos A, Perretti M, Fajac A, Sermet-Gaudelus I, Renouil M, Lesure JF, Halgand F, Laprevote O and Edelman A (2005). Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. Mol Cell Proteomics  vol. 4, (10) 1591-1601. 10.1074/mcp.M500019-MCP200

Gavins FNE, Sawmynaden P, Chatterjee BE and Perretti M (2005). A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor. Prostaglandins Leukot Essent Fatty Acids  vol. 73, (3-4) 211-219. 10.1016/j.plefa.2005.05.008

Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ and Perretti M (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol  vol. 78, (3) 639-646. 10.1189/jlb.0405206

Gilroy DW and Perretti M (2005). Aspirin and steroids: new mechanistic findings and avenues for drug discovery. Curr Opin Pharmacol  vol. 5, (4) 405-411. 10.1016/j.coph.2005.02.006

Yona S, Heinsbroek S, Gordon S, Perretti M and Flower RJ (2005). A novel role for Annexin 1 in macrophage phagocytosis. Inflamm Res  vol. 54, S217-S218. 10.1007/BF03354055

Marchand F, Perretti M and McMahon SB (2005). Role of the immune system in chronic pain. Nat Rev Neurosci  vol. 6, (7) 521-532. 10.1038/nrn1700

(2005). Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation. Am J Pathol  vol. 166, (6) 1607-1617. 10.1016/S0002-9440(10)62471-6

Maderna P, Yona S, Perretti M and Godson C (2005). Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide AC(2-26). J Immunol  vol. 174, (6) 3727-3733. 10.4049/jimmunol.174.6.3727

Flower RJ and Perretti M (2005). Controlling inflammation: a fat chance? J Exp Med  vol. 201, (5) 671-674. 10.1084/jem.20050222

Kamal AM, Flower RJ and Perretti M (2005). An overview of the effects of annexin 1 on cells involved in the inflammatory process. Mem Inst Oswaldo Cruz  vol. 100 Suppl 1, 39-47. 10.1590/s0074-02762005000900008

Zanardo RCO, Perretti M and Wallace JL (2005). Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage. Am J Physiol-Gastr L  vol. 288, (3) G481-G486. 10.1152/ajpgi.00299.2004

Basoni C, Nobles M, Grimshaw A, Desgranges C, Davies D, Perretti M, Kramer IM and Genot E (2005). Inhibitory control of TGF-beta 1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes. Faseb J  vol. 19, (3) 822-+. 10.1096/fj.04-3085fje

Lam CW, Getting SJ and Perretti M (2005). In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. J Immunol  vol. 174, (4) 2297-2304. 10.4049/jimmunol.174.4.2297

Yona S, Ward B, Buckingham JC, Perretti M and Flower RJ (2005). Macrophage biology in the Anx-A1-/- mouse. Prostaglandins Leukot Essent Fatty Acids  vol. 72, (2) 95-103. 10.1016/j.plefa.2004.10.008

Flower RJ, PERRETTI M, Diaz BL, Bandeira-Melo C, Martins MA, Carvalho VF, Silva PM, Jose PJ and Bonavita AG (2005). A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat. J Pharmacol Exp Ther  vol. 313, (3) 1416-1422. 10.1124/jpet.104.080473

Alam CAS, Seed MP, Freemantle C, Brown J, Perretti M, Carrier M, Divwedi A, West DC, Gustafson S, Colville-Nash PR and Willoughby DA (2005). The inhibition of neutrophil-endothelial cell adhesion by hyaluronan independent of CD44. Inflammopharmacology  vol. 12, (5-6) 535-550. 10.1163/156856005774382733

(2005). Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct. Faseb J  vol. 19, (1) 100-102. 10.1096/fj.04-2178fje

2004

Cao TV, La M, Getting SJ, Day AJ and Perretti M (2004). Inhibitory effects of TSG-6 link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation  vol. 11, (7) 615-624. 10.1080/10739680490503438

(2004). MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. J Leukocyte Biol  vol. 76, (4) 845-853. 10.1189/jlb.0306175

(2004). The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1. J Pharmacol Exp Ther  vol. 310, (3) 1133-1141. 10.1124/jpet.104.068726

Yona S, Buckingham JC, Perretti M and Flower RJ (2004). Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. Br J Pharmacol  vol. 142, (5) 890-898. 10.1038/sj.bjp.0705858

Perretti M and Flower RJ (2004). Annexin 1 and the biology of the neutrophil. J Leukoc Biol  vol. 76, (1) 25-29. 10.1189/jlb.1103552

MARTIN JE, Flower RJ, Perretti M, Hannon R, Getting SJ, Gavins FNE, Christian HC, Parente L, Paul-Clark MJ, Yona S, Oliani SM, Wells D, Cover PO, John CD, Solito E, Morris JF, Buckingham JC, Wells K, Liu K, Croxtall JD and Damazo AS (2004). The Annexin 1-/- Mouse: Phenotypic Studies. Annexins  vol. 1, (2) 109-120.

Perretti M and Solito E (2004). Annexin 1 and neutrophil apoptosis. Biochemical Society Transactions  vol. 32, 507-510. 10.1042/BST0320507

Pieretti S, Di Giannuario A, De Felice M, Perretti M and Cirino G (2004). Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides. Pain  vol. 109, (1-2) 52-63. 10.1016/j.pain.2004.01.009

Gilroy DW, Lawrence T, Perretti M and Rossi AG (2004). Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov  vol. 3, (5) 401-416. 10.1038/nrd1383

Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M and Nourshargh S (2004). Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol  vol. 172, (7) 4493-4502. 10.4049/jimmunol.172.7.4493

Yang YH, Morand EF, Getting SJ, Paul-Clark M, Liu DL, Yona S, Hannon R, Buckingham JC, Perretti M and Flower RJ (2004). Modulation of inflammation and response to dexamethasone by annexin 1 in antigen-induced arthritis. Arthritis Rheum  vol. 50, (3) 976-984. 10.1002/art.20201

Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S and Hobbs AJ (2004). Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. P Natl Acad Sci Usa  vol. 101, (5) 1386-1391. 10.1073/pnas.0304264101

Baraldi PG, Romagnoli R, Nunez MD, Perretti M, Paul-Clark MJ, Ferrario M, Govoni M, Benedini F and Ongini E (2004). Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide. J Med Chem  vol. 47, (3) 711-719. 10.1021/jm030964b

Moraes LA, Giner RM, Paul-Clark MJ, Perretti M and Perrett D (2004). An isocratic HPLC method for the quantitation of eicosanoids in human platelets. Biomed Chromatogr  vol. 18, (1) 64-68. 10.1002/bmc.349

PERRETTI M, Oliani SM, Takahashi HK, Damazo AS, Paul-Clark MJ and Straus AH (2004). Analysis of annexin 1 expression in rat trachea: study of mast cell heterogeneity. Annexins  vol. 1, 12-18.

2003

Perretti M (2003). The annexin 1 receptor(s): is the plot unravelling? Trends Pharmacol Sci  vol. 24, (11) 574-579. 10.1016/j.tips.2003.09.010

La M, Cao TV, Cerchiaro G, Chilton K, Hirabayashi J, Kasao K, Oliani SM, Chernajovsky Y and Perretti M (2003). A novel biological activity for galectin-1 - Inhibition of leukocyte-endothelial cell interactions in experimental inflammation. Am J Pathol  vol. 163, (4) 1505-1515. 10.1016/s0002-9440(10)63507-9

Paul-Clark MJ, Roviezzo F, Flower RJ, Cirino G, Del Soldato P, Adcock IM and Perretti M (2003). Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J Immunol  vol. 171, (6) 3245-3252. 10.4049/jimmunol.171.6.3245

Getting SJ, Schioth HB and Perretti M (2003). Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. J Pharmacol Exp Ther  vol. 306, (2) 631-637. 10.1124/jpet.103.051623

Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S and Perretti M (2003). A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. Faseb J  vol. 17, (9) 1544-+. 10.1096/fj.02-0941fje

Gavins FNE, Yona S, Kamal AM, Flower RJ and Perretti M (2003). Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Blood  vol. 101, (10) 4140-4147. 10.1182/blood-2002-11-3411

Perretti M, Paul-Clark MJ, Mancini L and Flower RJ (2003). Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids. Digest Liver Dis  vol. 35, S41-S48. 10.1016/S1590-8658(03)00051-3

Perretti M and Gavins FNE (2003). Annexin 1: an endogenous anti-inflammatory protein. News Physiol Sci  vol. 18, 60-64. 10.1152/nips.01424.2002

Getting SJ, Christian HC, Lam CW, Gavins FNE, Flower RJ, Schioth HB and Perretti M (2003). Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: Studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J Immunol  vol. 170, (6) 3323-3330. 10.4049/jimmunol.170.6.3323

Hannon R, Croxtall JD, Getting SJ, Roviezzo F, Yona S, Paul-Clark MJ, Gavins FNE, Perretti M, Morris JF, Buckingham JC and Flower RJ (2003). Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. Faseb J  vol. 17, (2) 253-255. 10.1096/fj.02-0239fje

PERRETTI M and Parente L (2003). Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochemical Pharmacology  vol. 65, (2) 153-159. 10.1016/s0006-2952(02)01422-3

Perretti M and Getting SJ (2003). Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo. 10.1385/1-59259-374-7:139

2002

Getting SJ, Mahoney DJ, Cao T, Rugg MS, Fries E, Milner CM, Perretti M and Day AJ (2002). The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem  vol. 277, (52) 51068-51076. 10.1074/jbc.M205121200

Fiorucci S, Antonelli E, Distrutti E, Del Soldato P, Flower RJ, Clark MJP, Morelli A, Perretti M and Ignarro LJ (2002). NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. P Natl Acad Sci Usa  vol. 99, (24) 15770-15775. 10.1073/pnas.232583599

Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E and Serhan CN (2002). Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med  vol. 8, (11) 1296-1302. 10.1038/nm786

Getting SJ, Christian HC, Flower RJ and Perretti M (2002). Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum  vol. 46, (10) 2765-2775. 10.1002/art.10526

Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E and Pitzalis C (2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. J Immunol  vol. 169, (4) 2085-2092. 10.4049/jimmunol.169.4.2085

Gibbs L, Carollo MG, Damazo AS, Oliani SM and Perretti M (2002). Time-dependent expression of annexin 1 in a model of chronic granulomatous inflammation. Inflamm Res  vol. 51, (6) 300-306. 10.1007/pl00000308

Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO, Perretti M and Pitzalis C (2002). Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J Immunol  vol. 168, (9) 4308-4317. 10.4049/jimmunol.168.9.4308

Calatayud S, Mitchell JA, Perretti M, Giuliano F and Warner TD (2002). Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery. Eur J Pharmacol  vol. 440, (1) 71-77. 10.1016/s0014-2999(02)01342-0

Ajuebor MN, Swain MG and Perretti M (2002). Chemokines as novel therapeutic targets in inflammatory diseases. Biochem Pharmacol  vol. 63, (7) 1191-1196. 10.1016/s0006-2952(02)00854-7

Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M and Pitzalis C (2002). Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice. Arthritis Rheum  vol. 46, (3) 824-836. 10.1002/art.10102

Malcangio M, Getting S, Grist J, Cunningham JR, Bradbury EJ, Issa PC, Lever IJ, Pezet S and Perretti M (2002). A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. Faseb J  vol. 16, (3) 730-+. 10.1096/fj.01-0971fje

Paul-Clark MJ, Mancini L, Del Soldato P, Flower RJ and Perretti M (2002). Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis. P Natl Acad Sci Usa  vol. 99, (3) 1677-1682. 10.1073/pnas.022641099

PERRETTI M, Damazo AS and Oliani SM (2002). Annexin 1 localisation in tissue eosinophils as detected by electron microscopy. Mediators of Inflammation.  vol. 11, 287-292. 10.1080/09629350210000015683

Ingegnoli F, Blades M, Manzo A, Wahid S, Perretti M, Panayi G and Pitzalis C (2002). Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane. Reumatismo  vol. 54, (2) 128-132. 10.4081/reumatismo.2002.128

Malcangio M, Getting SJ, Grist J, Cunningham JR, Bradbury EJ, Charbel Issa P, Lever IJ, Pezet S and Perretti M (2002). A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. The Faseb Journal : Official Publication of The Federation of American Societies For Experimental Biology  vol. 16, (7) 730-732.

PERRETTI M, Manzo A, Wheller SK, Ingegnoli F, Blades MC, Petzalis C, Wahid S and Panayi GS (2002). Stromal cell derived factor-1 (CXCL 12) induces monocyte migration into human synovium transplanted onto SCID mice. Arth Rheum  vol. 46, 824-836.

2001

Carollo M, Hogaboam CM, Kunkel SL, Delaney S, Christie MI and Perretti M (2001). Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1alpha and MCP-1. Br J Pharmacol  vol. 134, (6) 1166-1179. 10.1038/sj.bjp.0704371

Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virag L, Szabo E, Soriano FG, Liaudet L, Abdelkarim GE, Hasko G, Marton A, Southan GJ and Szabo C (2001). Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res  vol. 50, (11) 561-569. 10.1007/PL00000234

(2001). Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment. Eur J Pharmacol  vol. 429, (1-3) 263-278. 10.1016/s0014-2999(01)01325-5

de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M and Solito E (2001). Cytokine modulation of liver annexin 1 expression during experimental endotoxemia. Am J Pathol  vol. 159, (4) 1435-1443. 10.1016/S0002-9440(10)62530-8

Getting SJ and Perretti M (2001). Arthritic diseases: Melanocortin type 3 receptor agonists as potential therapeutics. Current Opinion in Investigational Drugs  vol. 2, (8) 1064-1069.

Damazo AS, de Lima WT, Perretti M and Oliani SM (2001). Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity. Eur J Pharmacol  vol. 426, (1-2) 123-130. 10.1016/s0014-2999(01)01093-7

Henderson RB, Lim LHK, Tessier PA, Gavins FNE, Mathies M, Perretti M and Hogg N (2001). The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha 4 integrin in the inflammatory response of neutrophils. J Exp Med  vol. 194, (2) 219-226. 10.1084/jem.194.2.219

Perretti M, Getting SJ, Solito E, Murphy PM and Gao JL (2001). Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol  vol. 158, (6) 1969-1973. 10.1016/S0002-9440(10)64667-6

Diaz B, Barreto E, Cordeiro R, Perretti M, Martins M and Silva P (2001). Enhanced serum glucocorticoid levels mediate the reduction of serosal mast cell numbers in diabetic rats. Life Sci  vol. 68, (26) 2925-2932. 10.1016/s0024-3205(01)01087-6

Solito E, de Coupade C, Canaider S, Goulding NJ and Perretti M (2001). Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. Brit J Pharmacol  vol. 133, (2) 217-228. 10.1038/sj.bjp.0704054

Blades MC, Ingegnoli F, Manzo A, Wahid S, Haskard D, Panayi G, Perretti M and Pitzalis C (2001). Development of a new model to investigate lymphocyte migration into human peripheral lymph nodes (HPLN) transplanted into SCID mice. Rheumatology  vol. 40, 66-66.

Oliani SM, Paul-Clark MJ, Christian HC, Flower RJ and Perretti M (2001). Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression. Am J Pathol  vol. 158, (2) 603-615. 10.1016/S0002-9440(10)64002-3

Oliani SM, Lim LHK, Christian HC, Pell K, Das AM and Perretti M (2001). Morphological alteration of peritoneal mast cells and macrophages in the mouse peritoneal cavity during the early phases of an allergic inflammatory reaction. Cell Biol Int  vol. 25, (8) 795-803. 10.1006/cbir.2001.0770

PERRETTI M, Obinger C, Furtmuller PG, Allegra M, Regelsberger G, Livrea MA, Tesoriere L and Turco-Leveri ML (2001). Mechanism of Reaction of Melatonin with Human Myeloperoxidase. Biochem Biophys Res Commun.  vol. 282, 380-386. 10.1006/bbrc.2001.4582

Allcock GH, Allegra M, Flower RJ and Perretti M (2001). Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1. Clin Exp Immunol  vol. 123, (1) 62-67. 10.1046/j.1365-2249.2001.01370.x

Getting SJ, Allcock GH, Flower R and Perretti M (2001). Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. J Leukoc Biol  vol. 69, (1) 98-104.

2000

Mancini L, Moradi-Bidhendi N, Brandi ML, Perretti M and MacIntyre I (2000). Modulation of the effects of osteoprotegerin (OPG) ligand in a human leukemic cell line by OPG and calcitonin. Biochem Bioph Res Co  vol. 279, (2) 391-397. 10.1006/bbrc.2000.3953

McLean PG, Perretti M and Ahluwalia A (2000). Kinin B1 receptors and the cardiovascular system: Regulation of expression and function. Cardiovascular Research  vol. 48, (2) 194-210. 10.1016/S0008-6363(00)00184-X

(2000). Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment. Faseb J  vol. 14, (13) 1867-1869. 10.1096/fj.99-0602fje

McLean PG, Ahluwalia A and Perretti M (2000). Association between kinin B1 receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules. Journal of Experimental Medicine  vol. 192, (3) 367-380. 10.1084/jem.192.3.367

Getting SJ and Perretti M (2000). MC3-R as a novel target for antiinflammatory therapy. Drug News and Perspectives  vol. 13, (1) 19-27.

McLean PG, Perretti M and Ahluwalia A (2000). Kinin B1 receptors as novel anti-inflammatory targets. Expert Opinion On Therapeutic Targets  vol. 4, (2) 127-141. 10.1517/14728222.4.2.127

Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ and Perretti M (2000). Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I). Life Sci  vol. 66, (18) PL265-PL270. 10.1016/s0024-3205(00)00500-2

Lim LHK, Flower RJ, Perretti M and Das AM (2000). Glucocorticoid receptor activation reduces CD11b and CD49d levels on murine eosinophils: Characterization and functional relevance. American Journal of Respiratory Cell and Molecular Biology  vol. 22, (6) 693-701. 10.1165/ajrcmb.22.6.3890

Paul-Clark M, Del Soldato P, Fiorucci S, Flower RJ and Perretti M (2000). 21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties. British Journal of Pharmacology  vol. 131, (7) 1345-1354. 10.1038/sj.bjp.0703704

Perretti M, Christian H, Wheller SK, Aiello I, Mugridge KG, Morris JF, Flower RJ and Goulding NJ (2000). Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. Cell Biology International  vol. 24, (3) 163-174. 10.1006/cbir.1999.0468

Perretti M and Ahluwalia A (2000). The microcirculation and inflammation: Site of action for glucocorticoids. Microcirculation  vol. 7, (3) 147-161. 10.1111/j.1549-8719.2000.tb00117.x

Oliani SM, Christian HC, Manston J, Flower RJ and Perretti M (2000). An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: Modulation by inflammation and dexamethasone. Laboratory Investigation  vol. 80, (9) 1429-1438. 10.1038/labinvest.3780150

Perretti M and Page CP (2000). Heparin and inflammation: a new use for an old GAG? Gut  vol. 47, (1) 14-15. 10.1136/gut.47.1.14

1999

McLean PG, Perretti M and Ahluwalia A (1999). Inducible expression of the kinin B1 receptor in the endotoxemic heart: Mechanisms of des-Arg⁹bradykinin-induced coronary vasodilation. British Journal of Pharmacology  vol. 128, (2) 275-282. 10.1038/sj.bjp.0702743

Das AM, Ajuebor MN, Flower RJ, Perretti M and McColl SR (1999). Contrasting roles for RANTES and macrophage inflammatory protein-1α (MIP-1α) in a murine model of allergic peritonitis. Clinical and Experimental Immunology  vol. 117, (2) 223-229. 10.1046/j.1365-2249.1999.00978.x

Getting SJ, Gibbs L, Clark AJL, Flower RJ and Perretti M (1999). POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. Journal of Immunology  vol. 162, (12) 7446-7453.

Ruetten H, Thiemermann C and Perretti M (1999). Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-κB but not protein tyrosine kinase: Comparison to induction of iNOS. Mediators of Inflammation  vol. 8, (2) 77-84. 10.1080/09629359990568

Ahluwalia A and Perretti M (1999). B1 receptors as a new inflammatory target. Could this B the 1? Trends in Pharmacological Sciences  vol. 20, (3) 100-104. 10.1016/S0165-6147(99)01321-8

Ajuebor MN, Das AM, Virág L, Szabó C and Perretti M (1999). Regulation of macrophage inflammatory protein-1α expression and function by endogenous interleukin-10 in a model of acute inflammation. Biochemical and Biophysical Research Communications  vol. 255, (2) 279-282. 10.1006/bbrc.1999.0196

Ajuebor MN, Das AM, Virág L, Flower RJ, Szabó C and Perretti M (1999). Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: Evidence for an inhibitory loop involving endogenous IL-10. Journal of Immunology  vol. 162, (3) 1685-1691.

Tailor A, Tomlinson A, Salas A, Panés J, Granger DN, Flower RJ and Perretti M (1999). Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: Role of intercellular adhesion molecule 1 and KC. Gut  vol. 45, (5) 705-712. 10.1136/gut.45.5.705

Perretti M, Wheller SK, Flower RJ, Wahid S and Pitzalis C (1999). Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. Journal of Leukocyte Biology  vol. 65, (5) 583-589. 10.1002/jlb.65.5.583

Euzger HS, Flower RJ, Goulding NJ and Perretti M (1999). Differential modulation of annexin I binding sites on monocytes and neutrophils. Mediators of Inflammation  vol. 8, (1) 53-62. 10.1080/09629359990720

Minghetti L, Nicolini A, Polazzi E, Greco A, Perretti M, Parente L and Levi G (1999). Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocartin 1. British Journal of Pharmacology  vol. 126, (6) 1307-1314. 10.1038/sj.bjp.0702423

1998

Ajuebor MN, Virág L, Flower RJ, Perretti M and Szabó C (1998). Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation. Immunology  vol. 95, (4) 625-630. 10.1046/j.1365-2567.1998.00644.x

Lim LH, Solito E, Russo-Marie F, Flower RJ and Perretti M (1998). Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A  vol. 95, (24) 14535-14539. 10.1073/pnas.95.24.14535

Perretti M (1998). Lipocortin 1 and chemokine modulation of granulocyte and monocyte accumulation in experimental inflammation. General Pharmacology  vol. 31, (4) 545-552. 10.1016/S0306-3623(98)00039-1

Ajuebor MN, Gibbs L, Flower RJ, Das AM and Perretti M (1998). Investigation of the functional role played by the chemokine monocyte chemoattractant protein-1 in interleukin-1-induced murine peritonitis. British Journal of Pharmacology  vol. 125, (2) 319-326. 10.1038/sj.bjp.0702071

(1998). Impaired IL-1β-induced neutrophil accumulation in tachykinin NK1 receptor knockout mice. British Journal of Pharmacology  vol. 124, (6) 1013-1015. 10.1038/sj.bjp.0701978

Pistritto G, Mancuso C, Tringali G, Perretti M, Preziosi P and Navarra P (1998). The relative contribution of constitutive and inducible cyclooxygenase activity to lipopolysaccharide-induced prostaglandin production by primary cultures of rat hypothalamic astrocytes. Neuroscience Letters  vol. 246, (1) 45-48. 10.1016/S0304-3940(98)00226-2

Teixeira MM, Das AM, Miotla JM, Perretti M and Hellewell PG (1998). The role of lipocortin-1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse. British Journal of Pharmacology  vol. 123, (3) 538-544. 10.1038/sj.bjp.0701625

Bryant CE, Perretti M and Flower RJ (1998). Suppression by dexamethasone of inducible nitric oxide synthase protein expression in vivo. A possible role for lipocortin 1. Biochemical Pharmacology  vol. 55, (3) 279-285. 10.1016/S0006-2952(97)00462-0

Das AM, Flower RJ and Perretti M (1998). Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo. Journal of Leukocyte Biology  vol. 64, (2) 156-162. 10.1002/jlb.64.2.156

Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A and Perretti M (1998). Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. Journal of Leukocyte Biology  vol. 63, (1) 108-116. 10.1002/jlb.63.1.108

1997

Das AM, Lim LHK, Flower RJ and Perretti M (1997). Dexamethasone reduces cell surface levels of CD11b on human eosinophils. Mediators of Inflammation  vol. 6, (5-6) 363-367. 10.1080/09629359791505

Cuzzocrea S, Tailor A, Zingarelli B, Salzman AL, Flower RJ, Szabó C and Perretti M (1997). Lipocortin 1 Protects Against Splanchnic Artery Occlusion and Reperfusion Injury by Affecting Neutrophil Migration. Journal of Immunology  vol. 159, (10) 5089-5097.

Perretti M (1997). Endogenous mediators that inhibit the leukocyte-endothelium interaction. Trends in Pharmacological Sciences  vol. 18, (11) 418-425. 10.1016/S0165-6147(97)01116-4

Szabó C, Lim LHK, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, Salzman AL and Perretti M (1997). Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. Journal of Experimental Medicine  vol. 186, (7) 1041-1049. 10.1084/jem.186.7.1041

Das AM, Flower RJ and Perretti M (1997). Eotaxin-Induced Eosinophil Migration in the Peritoneal Cavity of Ovalbumin-Sensitized Mice: Mechanism of Action. Journal of Immunology  vol. 159, (3) 1466-1473.

Wheller SK and Perretti M (1997). Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines. European Journal of Pharmacology  vol. 331, (1) 65-71. 10.1016/S0014-2999(97)01015-7

Ferreira SH, Cunha FQ, Lorenzetti BB, Michelin MA, Perretti M, Flower RJ and Poole S (1997). Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. British Journal of Pharmacology  vol. 121, (5) 883-888. 10.1038/sj.bjp.0701211

Tailor A, Das AM, Getting SJ, Flower RJ and Perretti M (1997). Subacute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes. Biochemical and Biophysical Research Communications  vol. 231, (3) 675-678. 10.1006/bbrc.1997.6168

Tailor A, Flower RJ and Perretti M (1997). Dexamethasone inhibits leukocyte emigration in rat mesenteric post- capillary venules: An intravital microscopy study. Journal of Leukocyte Biology  vol. 62, (3) 301-308. 10.1002/jlb.62.3.301

Getting SJ, Flower RJ, Parente L, De Medicis R, Lussier A, Woliztky BA, Martins MA and Perretti M (1997). Molecular determinants of monosodium urate crystal-induced murine peritonitis: A role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Journal of Pharmacology and Experimental Therapeutics  vol. 283, (1) 123-130.

Das AM, Flower RJ, Hellewell PG, Teixeira MM and Perretti M (1997). A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment. British Journal of Pharmacology  vol. 121, (1) 97-104. 10.1038/sj.bjp.0701122

Getting SJ, Flower RJ and Perretti M (1997). Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. British Journal of Pharmacology  vol. 120, (6) 1075-1082. 10.1038/sj.bjp.0701029

1996

Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon R and Flower RJ (1996). Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nature Medicine  vol. 2, (11) 1259-1262. 10.1038/nm1196-1259

Perretti M, Wheller SK, Harris JG and Flower RJ (1996). Modulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-1β and dexamethasone. Biochemical and Biophysical Research Communications  vol. 223, (1) 112-117. 10.1006/bbrc.1996.0854

Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA and Perretti M (1996). Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). Biochemical and Biophysical Research Communications  vol. 221, (3) 692-696. 10.1006/bbrc.1996.0658

Malcangio M, Bowery NG, Flower RJ and Perretti M (1996). Effect of interleukin-1β on the release of substance P from rat isolated spinal cord. European Journal of Pharmacology  vol. 299, (1-3) 113-118. 10.1016/0014-2999(95)00845-4

Perretti M, Ahluwalia A, Harris JG, Harris HJ, Wheller SK and Flower RJ (1996). Acute inflammatory response in the mouse: Exacerbation by immunoneutralization of lipocortin 1. British Journal of Pharmacology  vol. 117, (6) 1145-1154. 10.1111/j.1476-5381.1996.tb16709.x

Perretti M and Flower RJ (1996). Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: Modulation by glucocorticoids and inflammation. British Journal of Pharmacology  vol. 118, (3) 605-610. 10.1111/j.1476-5381.1996.tb15444.x

Ahluwalia A and Perretti M (1996). Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1β in vivo in the mouse. Journal of Immunology  vol. 156, (1) 269-274.

Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA and Perretti M (1996). Erratum: Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC) (Biochemical and Biophysical Research Communications (1996) 221 3 (692-696)). Biochemical and Biophysical Research Communications  vol. 224, (3) 878-879. 10.1006/bbrc.1996.1117

1995

Perretti M, Wheller SK, Choudhury Q, Croxtall JD and Flower RJ (1995). Selective inhibition of neutrophil function by a peptide derived from lipocortin 1 N-terminus. Biochemical Pharmacology  vol. 50, (7) 1037-1042. 10.1016/0006-2952(95)00238-U

Harris JG, Flower RJ and Perretti M (1995). Endogenous corticosteroids mediate the neutrophilia caused by platelet-activating factor in the mouse. European Journal of Pharmacology  vol. 283, (1-3) 9-18. 10.1016/0014-2999(95)00274-O

Klemm P, Harris HJ and Perretti M (1995). Effect of rolipram in a murine model of acute inflammation: comparison with the corticoid dexamethasone. European Journal of Pharmacology  vol. 281, (1) 69-74. 10.1016/0014-2999(95)00232-A

Palmi M, Frosini M, Sgaragli GP, Becherucci C, Perretti M and Parente L (1995). Inhibition of interleukin-1β-induced pyresis in the rabbit by peptide 204-212 of lipocortin 5. European Journal of Pharmacology  vol. 281, (1) 97-99. 10.1016/0014-2999(95)00304-4

Harris JG, Flower RJ and Perretti M (1995). Alteration of neutrophil trafficking by a lipocortin 1 N-terminus peptide. European Journal of Pharmacology  vol. 279, (2-3) 149-157. 10.1016/0014-2999(95)00145-B

Wu CC, Croxtall JD, Perretti M, Bryant CE, Thiemermann C, Flower RJ and Vane JR (1995). Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proceedings of The National Academy of Sciences of The United States of America  vol. 92, (8) 3473-3477. 10.1073/pnas.92.8.3473

Mancuso F, Flower RJ and Perretti M (1995). Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule: Involvement of endogenous lipocortin 1. Journal of Immunology  vol. 155, (1) 377-386.

Perretti M, Szabó C and Thiemermann C (1995). Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse. British Journal of Pharmacology  vol. 116, (4) 2251-2257. 10.1111/j.1476-5381.1995.tb15061.x

Mugridge KG, Perretti M, Ghiara P, Galeotti CL, Melli M and Parente L (1995). Gastric antisecretory and anti-ulcer actions of IL-1 in rat involve different IL-1 receptor types. American Journal of Physiology - Gastrointestinal and Liver Physiology  vol. 269, (5 32-5) 10.1152/ajpgi.1995.269.5.g763

1994

Ahluwalia A and Perretti M (1994). Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. European Journal of Pharmacology  vol. 264, (3) 407-415. 10.1016/0014-2999(94)00503-6

Perretti M (1994). Lipocortin-derived peptides. Biochemical Pharmacology  vol. 47, (6) 931-938. 10.1016/0006-2952(94)90402-2

Szabó C, Thiemermann C, Wu CC, Perretti M and Vane JR (1994). Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proceedings of The National Academy of Sciences of The United States of America  vol. 91, (1) 271-275. 10.1073/pnas.91.1.271

Perretti M and Flower RJ (1994). Cytokines, glucocorticoids and lipocortins in the control of neutrophil migration. Pharmacological Research  vol. 30, (1) 53-59. 10.1016/1043-6618(94)80087-1

Perretti M, Harris JG and Flower RJ (1994). A role for endogenous histamine in interleukin‐8‐induced neutrophil infiltration into mouse air‐pouch: investigation of the modulatory action of systemic and local dexamethasone. British Journal of Pharmacology  vol. 112, (3) 801-808. 10.1111/j.1476-5381.1994.tb13150.x

Ahluwalia A and Perretti M (1994). Anti-inflammatory effect of prostanoids in mouse and rat skin: Evidence for a role of EP3-receptors. Journal of Pharmacology and Experimental Therapeutics  vol. 268, (3) 1526-1531.

1993

Perretti M, Ahluwalia A, Flowers RJ and Manzini S (1993). Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: Involvement of NK-1 receptors. Immunology  vol. 80, (1) 73-77.

Perretti M, Ahluwalia A, Harris JG, Goulding NJ and Flower RJ (1993). Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil- dependent edema in the mouse: A qualitative comparison with an anti-CD11b monoclonal antibody. Journal of Immunology  vol. 151, (8) 4306-4314.

Perretti M, Duncan GS, Flower RJ and Peers SH (1993). Serum corticosterone, interleukin‐1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains. British Journal of Pharmacology  vol. 110, (2) 868-874. 10.1111/j.1476-5381.1993.tb13893.x

Perretti M, Flower RJ and Goulding NJ (1993). The ability of murine leukocytes to bind lipocortin 1 is lost during acute inflammation. Biochemical and Biophysical Research Communications  vol. 192, (2) 345-350. 10.1006/bbrc.1993.1421

Cirino G, Cicala C, Sorrentino L, Ciliberto G, Arpaia G, Perretti M and Flower RJ (1993). Anti‐inflammatory actions of an N‐terminal peptide from human lipocortin 1. British Journal of Pharmacology  vol. 108, (3) 573-574. 10.1111/j.1476-5381.1993.tb12843.x

Perretti M and Flower RJ (1993). Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1. Journal of Immunology  vol. 150, (3) 992-999.

Thiemermann C, Wu C, Szabó C, Perretti M and Vane JR (1993). Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. British Journal of Pharmacology  vol. 110, (1) 177-182. 10.1111/j.1476-5381.1993.tb13789.x

Da Silva JAP, Peers SH, Perretti M and Willoughby DA (1993). Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1. Journal of Endocrinology  vol. 136, (3) 389-397. 10.1677/joe.0.1360389

Becherucci C, Parente L, Perretti M and Mugridge KG (1993). Inhibition of smooth muscle contraction and platelet aggregation by peptide 204-212 of lipocortin 5: an attempt to define some structure requirements. Mediators of Inflammation  vol. 2, (2) 103-107. 10.1155/S0962935193000146

Becherucci C, Perretti M, Solito E, Galeotti CL and Parente L (1993). Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5. Mediators Inflamm  vol. 2, (2) 109-113. 10.1155/S0962935193000158

1992

Becherucci C, Perretti M, Nencioni L, Silvestri S and Parente L (1992). Anti-inflammatory effect of tuftsin and its retro-inverso analogue in rat adjuvant arthritis. Agents and Actions  vol. 36, (1 Supplement) 10.1007/BF01991043

Douglas GJ, Flower RJ, Parente L and Perretti M (1992). Peptide 204-212 of lipocortin 5 inhibits the generation of a prostacyclin-like factor from rat aorta preparations in vitro. Prostaglandins  vol. 44, (5) 381-388. 10.1016/0090-6980(92)90134-F

Parente L, Perretti M, Wallace JL and Mugridge KG (1992). Mechanism of the protective action of interleukin-1 in the experimental gastric damage in the rat. Pharmacological Research  vol. 26, (SUPPL. 2) 28-29. 10.1016/1043-6618(92)90584-X

Perretti M, Mugridge KG, Wallace JL and Parente L (1992). Reduction of aspirin-induced gastric damage in rats by interleukin-1β: Possible involvement of endogenous corticosteroids. Journal of Pharmacology and Experimental Therapeutics  vol. 261, (3) 1238-1247.

Perretti M, Solito E and Parente L (1992). Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice. Agents Actions  vol. 35, (1-2) 71-78. 10.1007/BF01990954

1991

Verdini AS, Pinori M, Silvestri S, Becherucci C, Longobardi MG, Parente L, Peppoloni S, Perretti M, Pileri P, Viscomi GC and Nencioni L (1991). Immunostimulation by a Partially Modified retro -in verso -Tuftsin Analogue Containing Thr¹ψ[NHCO](R,S)Lys² Modification. Journal of Medicinal Chemistry  vol. 34, (12) 3372-3379. 10.1021/jm00116a005

Perretti M, Becherucci C, Mugridge KG, Solito E, Silvestri S and Parente L (1991). A novel anti-inflammatory peptide from human lipocortin 5. Br J Pharmacol  vol. 103, (2) 1327-1332. 10.1111/j.1476-5381.1991.tb09788.x

Mugridge KG, Perretti M, Ghiara P and Parente L (1991). α-melanocyte-stimulating hormone reduces interleukin-lβ effects on rat stomach preparations possibly through interference with a type I receptor. European Journal of Pharmacology  vol. 197, (2-3) 151-155. 10.1016/0014-2999(91)90514-Q

Mugridge KG, Perretti M and Parente L (1991). 5-Lipoxygenase activation may facilitate an interleukin-1 transduction signal. Advances in Prostaglandin, Thromboxane, and Leukotriene Research  vol. 21 B, 517-520.

Perretti M, Mugridge KG, Becherucci C and Parente L (1991). Evidence that interleukin-1 and lipoxygenase metabolites mediate the lethal effect of complete Freund's adjuvant in adrenalectomized rats. Lymphokine and Cytokine Research  vol. 10, (4) 239-243.

Mugridge KG, Perretti M, Becherucci C and Parente L (1991). Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: Implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase. Journal of Pharmacology and Experimental Therapeutics  vol. 256, (1) 29-37.

Piaz VD, Ciciani G, Turco G, Giovannoni MP, Miceli M, Pirisino R and Perretti M (1991). 5‐Acyl‐6‐Aryl‐4‐Nitro‐3(2HH)Pyridazinones and related 4‐amino compounds: Synthesis and pharmacological evaluation. Journal of Pharmaceutical Sciences  vol. 80, (4) 341-348. 10.1002/jps.2600800412

1990

Becherucci C, Solito E, Perretti M, Mugridge KG, Galeotti CL and Parente L (1990). Purification and biological activity of human lipocortin 2. Pharmacol Res  vol. 22 Suppl 1, 29-30. 10.1016/1043-6618(90)90792-c

Perretti M, Mugridge KG, Becherucci C, Silvestri S and Parente L (1990). Antiulcer property of human recombinant interleukin-1β. Pharmacological Research  vol. 22, 10.1016/1043-6618(90)90427-F

Parente L, Mugridge KG, Perretti M and Solito E (1990). In vitro and in vivo activation of phospholipase A2 by interleukin-1. Pharmacological Research  vol. 22, 10.1016/1043-6618(90)90413-8

Becherucci C, Perretti M, Galeotti C and Parente L (1990). Different anti-inflammatory effects of lipocortins 1 and 5. Pharmacological Research  vol. 22, 10.1016/S1043-6618(09)80089-3

Perretti M, Nuti S and Parente L (1990). Investigation of rat mast cell degranulation using flow cytometry. Journal of Pharmacological Methods  vol. 23, (3) 187-194. 10.1016/0160-5402(90)90062-P

Parente L, Becherucci C, Perretti M, Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M and Sanso M (1990). Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids? Prog Clin Biol Res  vol. 349, 55-68.

1989

Becherucci C, Donati D, Perretti M and Parente L (1989). The release of interleukin-1-like activity by macrophages in two models of immunological inflammation in the rat. Agents and Actions  vol. 28, (3-4) 243-247. 10.1007/BF01967410

Perretti M, Becherucci C, Scapigliati G and Parente L (1989). The effect of adrenalectomy on interleukin-1 release in vitro and in vivo. British Journal of Pharmacology  vol. 98, (4) 1137-1142. 10.1111/j.1476-5381.1989.tb12657.x

1988

Ignesti G, Buffoni F, Perretti M and Cintelli A (1988). Induction and quail liver diamine oxidase (histaminase). Part II: Different responses to the inducers. Agents and Actions  vol. 25, (1-2) 43-47. 10.1007/BF01969092

Ignesti G, Perretti M and Buffoni F (1988). Induction and quail liver diamine oxidase (histaminase). Part I: Interference of spermidine synthase on the diamine oxidase activity assay using putrescine as substrate. Agents and Actions  vol. 25, (1-2) 37-42. 10.1007/BF01969091

Perretti M, Becherucci C and Parente L (1988). Interleukin-1 release by macrophages from adrenalectomized (ADX) and shamoperated (SHO) rats. Pharmacological Research Communications  vol. 20, (SUPPL. 2) 10.1016/S0031-6989(88)80429-6

Becherucci C, Donati D, Perretti M and Parente L (1988). Interleukin-1 release by rat macrophages in experimental immunological inflammation. Pharmacological Research Communications  vol. 20, (SUPPL. 2) 10.1016/S0031-6989(88)80159-0

1986

Ignesti G, Perretti M and Buffoni F (1986). Diamine oxidase activity in Japanese quail liver induced with Aroclor 1254. Agents and Actions  vol. 18, (1-2) 41-43. 10.1007/BF01987977

1981

Bombardieri G, Bevilacqua E, Conti LR, Innocenti P and Perretti MA (1981). Plasma amine oxidases in Wilson's disease. Life Sciences  vol. 29, (2) 117-120. 10.1016/0024-3205(81)90279-4

Grants

Grants of specific relevance to Predictive in vitro Models

New therapeutic targets for treating the failing heart in arthritis.
Perretti M and Cooper D
£115,000 Chernajovsky Foundation (01-04-2021 - 31-03-2024)

Summary

Analysis of novel melanocortin receptor peptide agonists - phase 2
Perretti M and Montero-Melendez T
£374,000 William Harvey Research Foundation (01-06-2021 - 31-05-2023)

Summary

Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis
Perretti M and Norling L
£230,000 EU (01-03-2019 - 28-02-2023)

Summary

Cardiomyopathy in RA
Perretti M, Norling L, Cooper D and Chen J
£230,000 Bristol-Myers Squibb (01-06-2021 - 30-11-2022)

Summary

Targeting Feutin-A as an innovative chondropretective strategy
Perretti M and Kaneva M
William Harvey Research Limited (03-08-2017 - 30-09-2022)

Summary

A New Therapeutic Approach to Cardioprotection for Myocardial Infarct Patients
Perretti M, CHEN J and Oggero S
£490,000 Barts Charity (01-03-2020 - 28-02-2022)

Summary

EVOLuTION - European Vascular Interventions and Therapeutic Innovation Network
Perretti M and Oggero S
£725,000 EU (01-04-2016 - 31-03-2021)

Cloning and Validation of an anti-arthritic ACTH species devoid of side effects
Perretti M and Montero-Melendez
£217,000 Versus Arthritis UK (01-10-2016 - 30-09-2019)

Neutrophil Vesicles as a novel auto logous regenerative therapeutic for joint disease
£236,000 MRC (04-09-2017 - 03-09-2019)

Summary

Treating the host in Dengue: mediators and pathways of resolution as a new therapeutic paradigm
Perretti M, Teixeira MMM, Pinho VS, Santiago HDC, Haworth OJ, Sousa LPD and Souza DG
£242,838 Medical Research Council (14-01-2016 - 13-01-2019)

Summary

The patho-physiology of the ALX receptor in inflammation.
Perretti M and Flower RJ
£1,167,240 Wellcome Trust (02-03-2009 - 01-07-2014)

Summary