Prof Mauro Perretti

Mauro Perretti
BSc, PhD

Professor of Immunopharmacology

The William Harvey Research Institute
Queen Mary University of London
02078828782
www.qmul.ac.uk/whri/people/academic-staff/items/perrettimauro.html
ORCID Google Scholar

Research

Therapeutic Innovation, Inflammation, Arthritis, Joint disease, Fibrosis

Cardiovascular Models, Infectious Disease and Inflammation Models, Musculoskeletal Models

Interests

Interest in co-culture settings that mimic the joint: macrophages, fibroblasts and chondrocytes. Keen to collaborate on bone cells.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity
Gonzalez Nuñez M, da Costa Vasconcellos LR, Garrido Mesa J, Cardoso Maciel Costa Silva R, Hachani A, Bosquet Agudo A, Simeoli R, Medrano Gonzalez L et al.
In Cold Spring Harbor Laboratory 
16-05-2025
Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritis
Margraf A, Chen J, Christoforou M, Claria-Ribas P, Henriques Schneider A, Cecconello C, Bu W, Imbert PRC et al.
Embo Molecular Medicine, Springer Science and Business Media Llc vol. 17 (5), 1153-1183.  
03-04-2025
Annexin A1/FPR2 pathway modulates leukocyte function during Escherichia coli‐induced pneumonia to promote resolution of inflammation and restores lung function
Lara ES, Carvalho AFS, Cardoso C, Zaidan I, Grossi LC, Carneiro FS, Lima EBS, Monteiro AHA et al.
British Journal of Pharmacology, Wiley vol. 182 (15), 3539-3558.  
01-04-2025
Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain
Oggero S, Voisin M-B, Picco F, Huerta MÁ, Cecconello C, Burgoyne T, Perretti M, Malcangio M
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 122 (11) 
10-03-2025
Formyl-peptide receptor type 2 activation mitigates secondary organ damage in inflammatory arthritis
Margraf A, Chen J, Christoforou M, Claria-Ribas P, Schneider AH, Cecconello C, Bu W, Imbert PRC et al.
In Cold Spring Harbor Laboratory 
08-02-2025

2024

Correction: Pessolano et al. Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System. Int. J. Mol. Sci. 2018, 19, 3878
Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L et al.
International Journal of Molecular Sciences, Mdpi Ag vol. 25 (17), 9349-9349.  
29-08-2024
Effects of a pro‐resolving drug in COVID‐19: preclinical studies to a randomized, placebo‐controlled, phase Ib/IIa trial in hospitalized patients
Almeida PRJ, Periard AM, Tana FL, Avila RE, Milhorato LB, Alcantara KMM, Resende CB, Serufo AV et al.
British Journal of Pharmacology, Wiley vol. 181 (23), 4750-4765.  
19-08-2024
Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis
Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D et al.
Arthritis &Amp; Rheumatology, Wiley vol. 76 (12), 1705-1718.  
16-08-2024
POS0250 GENERATION AND VALIDATION OF A HUMAN IMMUNE scFv LIBRARY FROM SJÖGREN’S SYNDROME SALIVARY GLAND B-CELLS
Corsiero E, Caliste M, Pontarini E, Dal Ferro M, Figini M, Luison E, Currado D, Perretti M et al.
 
01-06-2024
Doct.
Andriani A, Marchetti L, Rossi F, Raja S, Perretti MA, Recine U
Mediterranean Journal of Hematology and Infectious Diseases, Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy vol. 16 (1), e2024030-e2024030.  
29-02-2024
Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease
Walker ME, De Matteis R, Perretti M, Dalli J
Nature Communications, Springer Science and Business Media Llc vol. 15 (1) 
05-02-2024
Addendum: Resolvins suppress tumor growth and enhance cancer therapy
Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR et al.
Journal of Experimental Medicine, Rockefeller University Press vol. 221 (3) 
31-01-2024

2023

Report from the 2023 workshop on endothelial permeability, edema and inflammation
Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J et al.
Nature Cardiovascular Research, Springer Science and Business Media Llc vol. 2 (12), 1120-1124.  
08-12-2023
The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation
Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TEN et al.
Pharmacological Research, Elsevier Bv vol. 198, 107005-107005.  
01-12-2023
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
Granell R, Curtin JA, Haider S, Kitaba NT, Mathie SA, Gregory LG, Yates LL, Tutino M et al.
Elife, Elife Sciences Publications, Ltd vol. 12 
25-05-2023
Placental Inflammation Leads to Abnormal Embryonic Heart Development
Ward EJ, Bert S, Fanti S, Malone KM, Maughan RT, Gkantsinikoudi C, Prin F, Volpato LK et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 147 (12), 956-972.  
21-03-2023
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifiesANXA1as a susceptibility locus for persistent wheezing
Granell R, Curtin JA, Haider S, Kitaba N, Mathie S, Gregory L, Yates LL, Tutino M et al.
In Cold Spring Harbor Laboratory 
05-03-2023
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN et al.
Jci Insight, American Society For Clinical Investigation vol. 8 (3) 
08-02-2023
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation
Perretti M, Dalli J
Annual Review of Pharmacology and Toxicology, Annual Reviews vol. 63 (1), 449-469.  
20-01-2023
Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction
Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C, Perretti M
Journal of Innate Immunity, S. Karger Ag vol. 15 (1), 548-561.  
01-01-2023
RTP-026 promotes acute cardioprotection through formyl peptide receptor type 2 modulation of immune cell activation
Chen J, Oggero S, Cecconello C, Veng L, Jonassen T, Perretti M
 
01-01-2023

2022

Resolution pharmacology − A fresh approach to the clinical management of human inflammatory diseases
Perretti M, Subramanian M
Seminars in Immunology, Elsevier vol. 65 
22-12-2022
Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177
Garrido-Mesa J, Thomas BL, Dodd J, Spana C, Perretti M, Montero-Melendez T
Frontiers in Immunology, Frontiers Media Sa vol. 13 
24-11-2022
Neutrophil‐T cell crosstalk and the control of the host inflammatory response
Bert S, Nadkarni S, Perretti M
Immunological Reviews, Wiley vol. 314 (1), 36-49.  
03-11-2022
Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain
Oggero S, Cecconello C, Silva R, Zeboudj L, Sideris-Lampretsas G, Perretti M, Malcangio M
Brain, Behavior, and Immunity, Elsevier Bv vol. 106, 289-306.  
01-11-2022
Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection
de Araújo S, de Melo Costa VR, Santos FM, de Sousa CDF, Moreira TP, Gonçalves MR, Félix FB, Queiroz-Junior CM et al.
Cells, Mdpi Ag vol. 11 (17), 2717-2717.  
31-08-2022
Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35
Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M et al.
British Journal of Pharmacology, Wiley vol. 179 (19), 4617-4639.  
29-07-2022
Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients
Oggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P, Norling LV et al.
Journal of Hypertension, Ovid Technologies (Wolters Kluwer Health) vol. 40 (8), 1522-1529.  
21-06-2022
Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes
Margraf A, Perretti M
Cells, Mdpi Ag vol. 11 (11), 1824-1824.  
02-06-2022
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis
Gadipudi LL, Ramavath NN, Provera A, Reutelingsperger C, Albano E, Perretti M, Sutti S
Clinical Science, Portland Press Ltd. vol. 136 (9), 643-656.  
04-05-2022
The immunomodulatory effects of social isolation in mice are linked to temperature control
Hamilton A, Rizzo R, Brod S, Ono M, Perretti M, Cooper D, D'Acquisto F
Brain, Behavior, and Immunity, Elsevier Bv vol. 102, 179-194.  
01-05-2022
Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease
Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T et al.
Elife, Elife Sciences Publications, Ltd vol. 11 
16-03-2022
Placental inflammation leads to abnormal embryonic heart development
Ward EJ, Bert S, Fanti S, Dufton NP, Malone KM, Maughan RT, Prin F, Volpato LK et al.
In Cold Spring Harbor Laboratory 
12-03-2022
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice
Ferreira TPT, Guimarães FV, Sá YAPJ, da Silva Ribeiro NB, de Arantes ACS, de Frias Carvalho V, Sousa LP, Perretti M et al.
Cells, Mdpi Ag vol. 11 (5), 759-759.  
22-02-2022

2021

Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists
Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF et al.
European Journal of Medicinal Chemistry, Elsevier Bv vol. 226, 113805-113805.  
01-12-2021
Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease
Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves Pereira MH, Chen J, Gobbetti T et al.
In Cold Spring Harbor Laboratory 
03-11-2021
A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation
Man F, Nadkarni S, Kanabar V, e-Lacerda RR, Gomes Ferreira S, Federici Canova D, Perretti M, Page CP et al.
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society vol. 321 (5), L803-L813.  
01-11-2021
Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease
das Dores Pereira R, Rabelo RAN, Leite PG, Cramer A, Botelho AFM, Cruz JS, Régis WCB, Perretti M et al.
Cellular Immunology, Elsevier Bv vol. 369, 104427-104427.  
01-11-2021
Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease
de Paula-Silva M, da Rocha GHO, Broering MF, Queiroz ML, Sandri S, Loiola RA, Oliani SM, Vieira A et al.
Frontiers in Immunology, Frontiers Media Sa vol. 12 
17-09-2021
Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis
Chen J, Norling LV, Garrido Mesa J, Silva MDP, Burton SE, Reutelingsperger C, Perretti M, Cooper D
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 118 (38) 
15-09-2021
The Immunomodulatory Effects of Social Isolation in Mice are Linked to Temperature Control
Hamilton A, Rizzo R, Brod S, Ono M, Perretti M, Cooper D, D’Acquisto F
In Cold Spring Harbor Laboratory 
06-09-2021
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al.
Immunity, Elsevier Bv vol. 54 (9), 1989-2004.e9.  
01-09-2021
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19
Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 129 (4) 
06-08-2021
Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions
Coenen DM, Heinzmann ACA, Oggero S, Albers HJ, Nagy M, Hagué P, Kuijpers MJE, Vanderwinden J-M et al.
Cells, Mdpi Ag vol. 10 (8), 1998-1998.  
05-08-2021
Mesoglycan connects Syndecan‐4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro
Pessolano E, Belvedere R, Novizio N, Filippelli A, Perretti M, Whiteford J, Petrella A
The Febs Journal, Wiley vol. 288 (22), 6428-6446.  
22-06-2021
Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms)
de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M et al.
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 64 (13), 9193-9216.  
17-06-2021
Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions
Marques RM, Gonzalez-Nunez M, Walker ME, Gomez EA, Colas RA, Montero-Melendez T, Perretti M, Dalli J
Cell Death &Amp; Differentiation, Springer Science and Business Media Llc vol. 28 (11), 3140-3160.  
27-05-2021
WNT3A‐loaded exosomes enable cartilage repair
Thomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup A, Nalesso G, Caxaria S, Barawi A et al.
Journal of Extracellular Vesicles, Wiley vol. 10 (7) 
01-05-2021
Cell barrier function of resident peritoneal macrophages in post-operative adhesions
Ito T, Shintani Y, Fields L, Shiraishi M, Podaru M, Kainuma S, Yamashita K, Kobayashi K et al.
Nature Communications, Springer Science and Business Media Llc vol. 12 (1) 
14-04-2021
Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity
Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D et al.
Journal of Extracellular Vesicles, Wiley vol. 10 (6) 
01-04-2021
Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ, Perretti M
The Faseb Journal, Wiley vol. 35 (5) 
31-03-2021
Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation
Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, Chapman TM
European Journal of Medicinal Chemistry, Elsevier Bv vol. 214, 113194-113194.  
01-03-2021
Senescence under appraisal: hopes and challenges revisited
Davan-Wetton CSA, Pessolano E, Perretti M, Montero-Melendez T
Cellular and Molecular Life Sciences, Springer Science and Business Media Llc vol. 78 (7), 3333-3354.  
13-01-2021
Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E et al.
Mediators of Inflammation, Wiley vol. 2021 (1) 
01-01-2021

2020

Annexin A1 Released in Extracellular Vesicles by Pancreatic Cancer Cells Activates Components of the Tumor Microenvironment, through Interaction with the Formyl-Peptide Receptors
Novizio N, Belvedere R, Pessolano E, Tosco A, Porta A, Perretti M, Campiglia P, Filippelli A et al.
Cells, Mdpi Ag vol. 9 (12), 2719-2719.  
18-12-2020
microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression
Fitzsimons S, Oggero S, Bruen R, McCarthy C, Strowitzki MJ, Mahon NG, Ryan N, Brennan EP et al.
Frontiers in Immunology, Frontiers Media Sa vol. 11 
17-12-2020
RETRACTED: Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2
Belvedere R, Morretta E, Pessolano E, Novizio N, Tosco A, Porta A, Whiteford J, Perretti M et al.
Journal of Cellular Physiology, Wiley vol. 236 (7), 4926-4943.  
07-12-2020
Heparan sulfate binds the extracellular Annexin A1 and blocks its effects on pancreatic cancer cells
Belvedere R, Novizio N, Pessolano E, Tosco A, Eletto D, Porta A, Campiglia P, Perretti M et al.
Biochemical Pharmacology, Elsevier Bv vol. 182, 114252-114252.  
01-12-2020
Switching on resolution to treat RA moves closer to reality
Perretti M
Nature Reviews Rheumatology, Springer Science and Business Media Llc vol. 17 (2), 73-74.  
30-11-2020
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid
Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 205 (10), 2840-2849.  
15-11-2020
The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections
Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M, Norling LV
Frontiers in Immunology, Frontiers Media Sa vol. 11 
29-09-2020
Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology
Perretti M, Godson C
British Journal of Pharmacology, Wiley vol. 177 (20), 4595-4600.  
20-09-2020
WITHDRAWN: The Atlas of Inflammation Resolution (AIR)
Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T et al.
Molecular Aspects of Medicine, Elsevier Bv, 100893-100893.  
01-08-2020
The Atlas of Inflammation Resolution (AIR)
Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T et al.
Molecular Aspects of Medicine, Elsevier Bv vol. 74, 100894-100894.  
01-08-2020
Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells
Piras G, Rattazzi L, Paschalidis N, Oggero S, Berti G, Ono M, Bellia F, D'Addario C et al.
Brain, Behavior, and Immunity, Elsevier Bv vol. 87, 689-702.  
01-07-2020
Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst
Hebeda CB, Sandri S, Benis CM, Paula-Silva MD, Loiola RA, Reutelingsperger C, Perretti M, Farsky SHP
Cells, Mdpi Ag vol. 9 (5), 1188-1188.  
11-05-2020
Imbalance of proresolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis
Allen BL, Montague-Cardoso K, Simeoli R, Colas RA, Oggero S, Vilar B, McNaughton PA, Dalli J et al.
Pain, Ovid Technologies (Wolters Kluwer Health) vol. 161 (9), 2155-2166.  
04-05-2020
H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones
Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M
The Journal of Immunology, Oxford University Press (Oup) vol. 204 (9), 2374-2379.  
01-05-2020
Proresolving lipid mediators enhance PMN-mediated bacterial clearance
Norling LV, Perretti M
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 117 (17), 9148-9150.  
16-04-2020
Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin M-B, Vinci C et al.
Frontiers in Immunology, Frontiers Media Sa vol. 11 
14-02-2020
Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
Montero-Melendez T, Nagano A, Chelala C, Filer A, Buckley CD, Perretti M
Nature Communications, Springer Science and Business Media Llc vol. 11 (1) 
06-02-2020
Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation
McArthur S, Juban G, Gobbetti T, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 130 (3), 1156-1167.  
04-02-2020
Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound healing
Belvedere R, Pessolano E, Porta A, Tosco A, Parente L, Petrella F, Perretti M, Petrella A
European Journal of Pharmacology, Elsevier Bv vol. 869, 172894-172894.  
01-02-2020
The Atlas of Inflammation-Resolution (AIR)
Serhan CN, Gupta S, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T et al.
In Cold Spring Harbor Laboratory 
29-01-2020

2019

The Annexin A1/FPR2 pathway controls the inflammatory response and bacterial dissemination in experimental pneumococcal pneumonia
Machado MG, Tavares LP, Souza GVS, Queiroz‐Junior CM, Ascenção FR, Lopes ME, Garcia CC, Menezes GB et al.
The Faseb Journal, Wiley vol. 34 (2), 2749-2764.  
26-12-2019
Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions
Sinniah A, Yazid S, Bena S, Oliani SM, Perretti M, Flower RJ
Frontiers in Pharmacology, Frontiers Media Sa vol. 10 
13-11-2019
Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque responses
Oggero S, de Gaetano M, Marcone S, Barry M, Montero-Melendez T, Cooper D, Norling LV, Brennan EP et al.
In Cold Spring Harbor Laboratory 
13-11-2019
Immuno-moodulin: a new anxiogenic factor produced by autoimmune-prone T cells
Piras G, Rattazzi L, Paschalidis N, Oggero S, Berti G, Ono M, Bellia F, D’Addario C et al.
In Cold Spring Harbor Laboratory 
08-10-2019
Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway
Barbosa CMV, Fock RA, Hastreiter AA, Reutelingsperger C, Perretti M, Paredes-Gamero EJ, Farsky SHP
Cell Death Discovery, Springer Science and Business Media Llc vol. 5 (1) 
23-09-2019
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance
Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P et al.
Kidney International, Elsevier Bv vol. 96 (2), 397-408.  
01-08-2019
Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation
Senchenkova EY, Ansari J, Becker F, Vital SA, Al-Yafeai Z, Sparkenbaugh EM, Pawlinski R, Stokes KY et al.
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 140 (4), 319-335.  
23-07-2019
Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs
Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Petrella F, Porta A, Tosco A et al.
Cells, Mdpi Ag vol. 8 (7), 753-753.  
19-07-2019
The formyl peptide fMLF primes platelet activation and augments thrombus formation
Salamah MF, Ravishankar D, Vaiyapuri R, Moraes LA, Patel K, Perretti M, Gibbins JM, Vaiyapuri S
Journal of Thrombosis and Haemostasis, Elsevier Bv vol. 17 (7), 1120-1133.  
01-07-2019
Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes
Vago JP, Sugimoto MA, Lima KM, Negreiros-Lima GL, Baik N, Teixeira MM, Perretti M, Parmer RJ et al.
Frontiers in Immunology, Frontiers Media Sa vol. 10 
28-06-2019
Mesoglycan induces keratinocyte activation by triggering syndecan‐4 pathway and the formation of the annexin A1/S100A11 complex
Bizzarro V, Belvedere R, Pessolano E, Parente L, Petrella F, Perretti M, Petrella A
Journal of Cellular Physiology, Wiley vol. 234 (11), 20174-20192.  
08-04-2019
Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: a potential involvement of immune cell cross-talk
Nadkarni S, Lashin H, Hollywood J, Dasgupta B, Mason JC, Perretti M
Clinical Science, Portland Press Ltd. vol. 133 (7), 839-851.  
04-04-2019
Neutrophil elastase plays a non‐redundant role in remodeling the venular basement membrane and neutrophil diapedesis post‐ischemia/reperfusion injury
Voisin M, Leoni G, Woodfin A, Loumagne L, Patel NSA, Di Paola R, Cuzzocrea S, Thiemermann C et al.
The Journal of Pathology, Wiley vol. 248 (1), 88-102.  
22-03-2019
Formyl peptide receptor 1 signalling promotes experimental colitis in mice
Di Paola R, Fusco R, Gugliandolo E, D’Amico R, Cordaro M, Impellizzeri D, Perretti M, Cuzzocrea S
Pharmacological Research, Elsevier Bv vol. 141, 591-601.  
01-03-2019
Mediators of the Resolution of the Inflammatory Response
Sugimoto MA, Vago JP, Perretti M, Teixeira MM
Trends in Immunology, Elsevier Bv vol. 40 (3), 212-227.  
01-03-2019
Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E et al.
European Journal of Medicinal Chemistry, Elsevier Bv vol. 162, 80-108.  
01-01-2019
Protective role of a synthetic LipoxinA4 mimetic (sLXm) in an in vivo model of sepsis
Cacace A, Chen J, de Gaetano M, Marai M, Guiry P, Gahan K, Brennan E, Perretti M et al.
 
01-01-2019
Characterization of calreticulin, a stromal-derived autoantigens, recognized by RA synovial recombinant monoclonal antibodies
Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M
 
01-01-2019
Monocyte and not Neutrophil derived microvesicles are able to activate endothelial cells and smooth muscle cells and to enhance recruitment of PMN in a Flow Chamber based assay
Oggero S, Van Gorp R, Cooper D, Norling L, Schurgers L, Reutelinsperger C, Perretti M
 
01-01-2019

2018

Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System
Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L et al.
International Journal of Molecular Sciences, Mdpi Ag vol. 19 (12), 3878-3878.  
04-12-2018
Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms
Petri MH, Thul S, Andonova T, Lindquist-Liljeqvist M, Jin H, Skenteris N-T, Arnardottir H, Maegdefessel L et al.
Jacc: Basic to Translational Science, Elsevier Bv vol. 3 (6), 719-727.  
01-12-2018
The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation
Salamah MF, Ravishankar D, Kodji X, Moraes LA, Williams HF, Vallance TM, Albadawi DA, Vaiyapuri R et al.
Blood Advances, American Society of Hematology vol. 2 (21), 2973-2985.  
09-11-2018
n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis
Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K et al.
Brain, Oxford University Press (Oup) 
10-10-2018
Neutrophil wrap
Thomas BL, Perretti M
Nature Nanotechnology, Springer Science and Business Media Llc vol. 13 (12), 1098-1099.  
03-09-2018
Characterization of a Synovial B Cell–Derived Recombinant Monoclonal Antibody Targeting Stromal Calreticulin in the Rheumatoid Joints
Corsiero E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M
The Journal of Immunology, Oxford University Press (Oup) vol. 201 (5), 1373-1381.  
01-09-2018
Ligand Bias and Its Association With Pro-resolving Actions of Melanocortin Drugs
Patruno S, Garrido-Mesa J, Romano M, Perretti M, Montero-Melendez T
Frontiers in Pharmacology, Frontiers Media Sa vol. 9 
14-08-2018
Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation
McArthur S, Gobbetti T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP et al.
 
04-08-2018
Potential engagement of pathways of the resolution of inflammation as mechanism of action for plants on animal models
Piovezan AP, Perretti M
Journal of Ethnopharmacology, Elsevier Bv vol. 221, 160-161.  
01-07-2018
Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo
Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D et al.
Scientific Reports, Springer Science and Business Media Llc vol. 8 (1) 
02-05-2018
Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis
Lashin HMS, Nadkarni S, Oggero S, Jones HR, Knight JC, Hinds CJ, Perretti M
Shock, Ovid Technologies (Wolters Kluwer Health) vol. 49 (4), 393-401.  
01-04-2018
Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis
Thomas BL, Jones HR, Norling LV, Headland SE, Pitzalis C, Dell'Accio F, Perretti M
 
01-04-2018
Formyl peptide receptor 1 signalling promotes experimental colitis in mice
Fusco R, Di Paola R, Gugliandolo E, D'Amico R, Perretti M, Cuzzocrea S
The Faseb Journal, Wiley vol. 32 (S1) 
01-04-2018
Endogenous annexin A1 (AnxA1) modulates early‐phase gestation and offspring sex‐ratio skewing
Hebeda CB, Machado ID, Reif‐Silva I, Moreli JB, Oliani SM, Nadkarni S, Perretti M, Bevilacqua E et al.
Journal of Cellular Physiology, Wiley vol. 233 (9), 6591-6603.  
07-03-2018
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages
Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M
Ebiomedicine, Elsevier Bv vol. 29, 60-69.  
01-03-2018
Investigating the binding modes and structure-activity relationships of small molecule FPR2 agonists using receptor homology modelling
Maciuszek M, Chapman T, Nicoales G, Birchall K, Reutelingsperger C, Perretti M, Merritt A
 
01-01-2018
MODULATION OF DIABETIC RETINOPATHY BY MELANOCORTIN MC1 AND MC5 RECEPTOR SUBTYPES ACTIVATION IN A MOUSE MODEL OF STZ-INDUCED DIABETIC RETINOPATHY AND RETINAL CELLS CULTURE
Maisto R, Gesualdo C, Trotta MC, Rossi S, Simonelli F, Grieco P, Merlino F, Perretti M et al.
 
01-01-2018
Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases?
Oggero S, Norling L, Perretti M
Proceedings For Annual Meeting of The Japanese Pharmacological Society, Japanese Pharmacological Society vol. WCP2018 
01-01-2018

2017

Actions of SPM in regulating host responses in arthritis
Perretti M, Norling LV
Molecular Aspects of Medicine, Elsevier Bv vol. 58, 57-64.  
01-12-2017
Resolvins suppress tumor growth and enhance cancer therapy
Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR et al.
Journal of Experimental Medicine, Rockefeller University Press vol. 215 (1), 115-140.  
30-11-2017
Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo
Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D et al.
Scientific Reports, Springer Science and Business Media Llc vol. 7 (1) 
30-11-2017
Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
Simeoli R, Montague K, Jones HR, Castaldi L, Chambers D, Kelleher JH, Vacca V, Pitcher T et al.
Nature Communications, Springer Science and Business Media Llc vol. 8 (1) 
24-11-2017
Resolution in an ‘over-inflamed’ era
Perretti M, MonteroMelendez T
The Biochemist, Portland Press Ltd. vol. 39 (4), 4-7.  
01-08-2017
The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1
Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF et al.
Journal of Biological Chemistry, Elsevier vol. 292 (33), 13758-13773.  
27-06-2017
Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation
Gittens BR, Bodkin JV, Nourshargh S, Perretti M, Cooper D
The Journal of Immunology, Oxford University Press (Oup) vol. 198 (11), 4458-4469.  
01-06-2017
Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways
Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ et al.
Journal of Ethnopharmacology, Elsevier Bv vol. 204, 179-188.  
01-05-2017
Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide
Perretti M, Di Filippo C, D’Amico M, Dalli J
Plos One, Public Library of Science (Plos) vol. 12 (4), e0175786-e0175786.  
13-04-2017
The impact of environmental enrichment on the murine inflammatory immune response
Brod S, Gobbetti T, Gittens B, Ono M, Perretti M, D’Acquisto F
Jci Insight, American Society For Clinical Investigation vol. 2 (7) 
06-04-2017
Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 198 (7), 2876-2885.  
01-04-2017
Protectin D1\n n-3 DPA\n and resolvin D5\n n-3 DPA\n are effectors of intestinal protection
Gobbetti T, Dalli J, Colas RA, Federici Canova D, Aursnes M, Bonnet D, Alric L, Vergnolle N et al.
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 114 (15), 3963-3968.  
29-03-2017
Aspirin‐triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E−/− mice
Petri MH, Laguna‐Fernandez A, Arnardottir H, Wheelock CE, Perretti M, Hansson GK, Bäck M
British Journal of Pharmacology, Wiley vol. 174 (22), 4043-4054.  
14-02-2017
Immune resolution mechanisms in inflammatory arthritis
Perretti M, Cooper D, Dalli J, Norling LV
Nature Reviews Rheumatology, Springer Science and Business Media Llc vol. 13 (2), 87-99.  
05-01-2017
Annexin A1 supplementation prevents the progression to fibrosis of nonalcoholic steatoepatitis (NASH)
Bruzzì S, Sutti S, Toscani A, Bozzola C, Reutelingsperger C, Kusters D, Mcarthur S, Perretti M et al.
 
01-01-2017
PRORESOLVING ANTIINFLAMMATORY MECHANISMS ARE NOVEL POTENTIAL TARGETS AGAINST EPILEPTOGENESIS
Frigerio F, Colas R, Marchini S, van Vliet E, Foerch P, Aronica E, Perretti M, Dalli J et al.
 
01-01-2017

2016

Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy
Nadkarni S, Smith J, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Mauro C, Williams DJ et al.
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 113 (52) 
12-12-2016
Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3
Montero-Melendez T, Forfar RAE, Cook JM, Jerman JC, Taylor DL, Perretti M
Cellular and Molecular Life Sciences, Springer Science and Business Media Llc vol. 74 (7), 1335-1345.  
16-11-2016
An orally administered butyrate‐releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium‐induced murine colitis
Simeoli R, Mattace Raso G, Pirozzi C, Lama A, Santoro A, Russo R, Montero‐Melendez T, Berni Canani R et al.
British Journal of Pharmacology, Wiley vol. 174 (11), 1484-1496.  
03-11-2016
Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation
Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M, Serhan CN
The Journal of Immunology, Oxford University Press (Oup) vol. 197 (6), 2362-2368.  
15-09-2016
Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection
Madeira MFM, Queiroz‐Junior CM, Montero‐Melendez T, Werneck SMC, Corrêa JD, Soriani FM, Garlet GP, Souza DG et al.
The Faseb Journal, Wiley vol. 30 (12), 4033-4041.  
17-08-2016
Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo
Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al.
Annals of The Rheumatic Diseases, Elsevier Bv vol. 75 (6), 1228-1235.  
01-06-2016
SAT0026 Pro-Resolving and Cartilage-Protective Actions of Resolvin D1 in Inflammatory Arthritis
Norling L, Headland S, Dalli J, Arnardottir H, Jones H, Haworth O, Serhan C, Perretti M
 
01-06-2016
AB0077 Targeting Synovial Fibroblasts with Melanocortin Drugs
Montero-Melendez T, Buckley CD, Filer A, Turner JD, Perretti M
 
01-06-2016
Formyl-Peptide Receptor 2/3/Lipoxin A\n 4\n Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation
Vital SA, Becker F, Holloway PM, Russell J, Perretti M, Granger DN, Gavins FNE
Circulation, Ovid Technologies (Wolters Kluwer Health) vol. 133 (22), 2169-2179.  
31-05-2016
IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD
Chen J, Kieswich JE, Chiazza F, Moyes AJ, Gobbetti T, Purvis GSD, Salvatori DCF, Patel NSA et al.
Journal of The American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health) vol. 28 (1), 94-105.  
06-05-2016
Resolution of Inflammation: What Controls Its Onset?
Sugimoto MA, Sousa LP, Pinho V, Perretti M, Teixeira MM
Frontiers in Immunology, Frontiers Media Sa vol. 7 
26-04-2016
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN et al.
Jci Insight, American Society For Clinical Investigation vol. 1 (5) 
21-04-2016
The role of neutrophils in inflammation resolution
Jones HR, Robb CT, Perretti M, Rossi AG
Seminars in Immunology, Elsevier Bv vol. 28 (2), 137-145.  
01-04-2016
d‐Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine‐γ‐lyase
Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T et al.
British Journal of Pharmacology, Wiley vol. 173 (9), 1556-1565.  
23-03-2016
Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway
Machado ID, Spatti M, Hastreiter A, Santin JR, Fock RA, Gil CD, Oliani SM, Perretti M et al.
Journal of Cellular Physiology, Wiley vol. 231 (11), 2418-2427.  
08-03-2016
Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1
Vago JP, Tavares LP, Sugimoto MA, Lima GLN, Galvão I, de Caux TR, Lima KM, Ribeiro ALC et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 196 (4), 1922-1932.  
15-02-2016
The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil
Sinniah A, Yazid S, Perretti M, Solito E, Flower RJ
International Immunopharmacology, Elsevier vol. 32, 87-95.  
21-01-2016
Activation of Melanocortin Receptors MC1and MC5Attenuates Retinal Damage in Experimental Diabetic Retinopathy
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E et al.
Mediators of Inflammation, Hindawi Limited vol. 2016, 1-13.  
01-01-2016
Activation of melanocortin receptors Mc1 and Mc5 attenuates retinal damage in experimental diabetic retinopathy
Di Perna L, Gesualdo C, Maisto R, Di Filippo C, Perretti M, Testa F, Rossi S, D'amico M et al.
 
01-01-2016

2015

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 7 (315) 
25-11-2015
Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response
Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB et al.
Journal of Controlled Release, Elsevier Bv vol. 217, 284-292.  
01-11-2015
Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation
Perretti M, Leroy X, Bland EJ, Montero-Melendez T
Trends in Pharmacological Sciences, Elsevier Bv vol. 36 (11), 737-755.  
01-11-2015
Both MC\n 1\n and MC\n 3\n Receptors Provide Protection From Cerebral Ischemia-Reperfusion–Induced Neutrophil Recruitment
Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 35 (9), 1936-1944.  
01-09-2015
Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation
McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ, Perretti M
The Journal of Immunology, Oxford University Press (Oup) vol. 195 (3), 1139-1151.  
01-08-2015
Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M et al.
Plos Biology, Public Library of Science (Plos) vol. 13 (7), e1002202-e1002202.  
16-07-2015
Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet
Kusters DHM, Chatrou ML, Willems BAG, De Saint-Hubert M, Bauwens M, van der Vorst E, Bena S, Biessen EAL et al.
Plos One, Public Library of Science (Plos) vol. 10 (6), e0130484-e0130484.  
19-06-2015
The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology
Perretti M
Seminars in Immunology, Elsevier Bv vol. 27 (3), 145-148.  
01-05-2015
Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice
Trentin PG, Ferreira TPT, Arantes ACS, Ciambarella BT, Cordeiro RSB, Flower RJ, Perretti M, Martins MA et al.
British Journal of Pharmacology, Wiley vol. 172 (12), 3058-3071.  
10-04-2015
Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects
Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TEN, Perretti M
The Journal of Immunology, Oxford University Press (Oup) vol. 194 (7), 3381-3388.  
01-04-2015
Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen
Amoruso A, Fresu LG, Dalli J, Miglietta D, Bardelli C, Canova DF, Perretti M, Brunelleschi S
Life Sciences, Elsevier Bv vol. 126, 28-36.  
01-04-2015
‘Annexins’ themed section
Flower RJ, Perretti M
British Journal of Pharmacology, Wiley vol. 172 (7), 1651-1652.  
16-03-2015
Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice
Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 7 (275) 
18-02-2015
Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair
Leoni G, Neumann P-A, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 125 (3), 1215-1227.  
09-02-2015
Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation
Petri MH, Laguna-Fernandez A, Tseng C-N, Hedin U, Perretti M, Bäck M
International Journal of Cardiology, Elsevier Bv vol. 179, 370-372.  
01-01-2015
THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING IκB KINASE
Chen J, Kieswich J, Chiazza F, Gobbetti T, Patel NS, Perretti M, Collino M, Yaqoob MM et al.
 
01-01-2015

2014

Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders
Gallo I, Rattazzi L, Piras G, Gobbetti T, Panza E, Perretti M, Dalley JW, D'Acquisto F
Plos One, Public Library of Science (Plos) vol. 9 (12), e114626-e114626.  
17-12-2014
Protective effects of n‐6 fatty acids‐enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor
Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand‐Michel J, Dubourdeau M et al.
British Journal of Pharmacology, Wiley vol. 172 (3), 910-923.  
15-12-2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis
Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C et al.
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 111 (52), 18685-18690.  
15-12-2014
Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor
Thompson D, McArthur S, Hislop JN, Flower RJ, Perretti M
Journal of Biological Chemistry, Elsevier Bv vol. 289 (52), 36166-36178.  
01-12-2014
Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions
Machado ID, Santin JR, Drewes CC, Gil CD, Oliani SM, Perretti M, Farsky SHP
American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society vol. 307 (9), E754-E763.  
01-11-2014
Annexin A1 Mediates Hydrogen Sulfide Properties in the Control of Inflammation
Brancaleone V, Mitidieri E, Flower RJ, Cirino G, Perretti M
The Journal of Pharmacology and Experimental Therapeutics, Elsevier Bv vol. 351 (1), 96-104.  
01-10-2014
Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell’Accio F, Perretti M
Biochemical Pharmacology, Elsevier Bv vol. 91 (3), 348-358.  
01-10-2014
Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B\n 4\n synthesis by inhibiting a calcium-activated kinase pathway
Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, Tabas I
 
22-09-2014
AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE−/− mice
Burgmaier M, Schutters K, Willems B, van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL et al.
Journal of Cellular and Molecular Medicine, Wiley vol. 18 (10), 2117-2124.  
12-09-2014
Resolution of inflammation: examples of peptidergic players and pathways
Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D, Perretti M
Drug Discovery Today, Elsevier Bv vol. 19 (8), 1166-1171.  
01-08-2014
Association between Periodontal Disease and Inflammatory Arthritis Reveals Modulatory Functions by Melanocortin Receptor Type 3
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA, Perretti M
The American Journal of Pathology, Elsevier Bv vol. 184 (8), 2333-2341.  
01-08-2014
Resolution of inflammation: targeting GPCRs that interact with lipids and peptides
Cash JL, Norling LV, Perretti M
Drug Discovery Today, Elsevier Bv vol. 19 (8), 1186-1192.  
01-08-2014
Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S et al.
Hepatology, Ovid Technologies (Wolters Kluwer Health) vol. 60 (2), 531-544.  
01-08-2014
Connections in pharmacology: innovation serving translational medicine
Montero-Melendez T, Perretti M
Drug Discovery Today, Elsevier Bv vol. 19 (7), 820-823.  
01-07-2014
Cutting-Edge Analysis of Extracellular Microparticles using ImageStreamX Imaging Flow Cytometry
Headland SE, Jones HR, D'Sa ASV, Perretti M, Norling LV
Scientific Reports, Springer Science and Business Media Llc vol. 4 (1) 
10-06-2014
OP0296 Hypoxia-Inducible Factor 2A Regulates Macrophage Function in Rheumatoid Arthritis
Hardy W, Wright F, Hawtree S, Fearon U, Veale D, Perretti M, Wilson A, Muthana M
 
01-06-2014
Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain
Old EA, Nadkarni S, Grist J, Gentry C, Bevan S, Kim K-W, Mogg AJ, Perretti M et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 124 (5), 2023-2036.  
17-04-2014
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ et al.
Nature Communications, Springer Science and Business Media Llc vol. 5 (1) 
14-03-2014
Gapdh Gene Expression Is Modulated by Inflammatory Arthritis and Is not Suitable for qPCR Normalization
Montero-Melendez T, Perretti M
Inflammation, Springer Science and Business Media Llc vol. 37 (4), 1059-1069.  
04-02-2014
Investigational Analysis Reveals a Potential Role for Neutrophils in Giant-Cell Arteritis Disease Progression
Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B, Perretti M
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 114 (2), 242-248.  
17-01-2014
NEUTROPHILS IN GCA
Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B, Perretti M
 
01-01-2014
IN PATIENTS WITH SEVERE SEPSIS MICROPARTICLE PROFILES DIFFER ACCORDING TO THE SOURCE OF INFECTION
Lashin H, Nadkarni S, Hinds C, Perretti M
 
01-01-2014
ANNEXIN A1 AND PPARγ ON RESOLUTION OF INFLAMMATION
Farsky SHP, Santin JR, Takahama C, Machado ID, Teixeira S, Muscara MN, Pitta IR, Solito E et al.
 
01-01-2014
TRANSLATIONAL MEDICINE IN RHEUMATOID ARTHRITIS: EXPLOITING MELANOCORTIN RECEPTORS
Ahmed TJ, Perretti M, Pitzalis C
 
01-01-2014
THE CARDIOPROTECTIVE ROLE OF THE ANXA1/FPR2 PATHWAY
Bena S, Gobbetti T, D'Amico M, Flower R, Perretti M
 
01-01-2014

2013

Microparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis
Dalli J, Norling LV, Montero‐Melendez T, Canova DF, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ et al.
Embo Molecular Medicine, Springer Science and Business Media Llc vol. 6 (1), 27-42.  
16-12-2013
Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling
Montero-Meléndez T, Llor X, García-Planella E, Perretti M, Suárez A
Plos One, Public Library of Science (Plos) vol. 8 (10), e76235-e76235.  
14-10-2013
Ligand-specific conformational change of the G-protein–coupled receptor ALX/FPR2 determines proresolving functional responses
Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ, Perretti M
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 110 (45), 18232-18237.  
09-10-2013
Chemerin15 inhibits neutrophil‐mediated vascular inflammation and myocardial ischemia‐reperfusion injury through ChemR23
Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V, Perretti M
Embo Reports, Springer Science and Business Media Llc vol. 14 (11), 999-1007.  
03-09-2013
OP06 Annexin A1 (AnxA1) mediates hydrogen sulfide (H2S) effects in the control of inflammation
Brancaleone V, Flower RJ, Cirino G, Perretti M
 
01-09-2013
Heterogeneity in Neutrophil Microparticles Reveals Distinct Proteome and Functional Properties
Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M, Perretti M
Molecular &Amp; Cellular Proteomics, Elsevier Bv vol. 12 (8), 2205-2219.  
01-08-2013
Novel pathways in the yin-yang of immunomodulation
Godson C, Perretti M
Current Opinion in Pharmacology, Elsevier Bv vol. 13 (4), 543-546.  
01-08-2013
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S et al.
Blood, American Society of Hematology vol. 122 (4), 608-617.  
25-07-2013
Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis
Iqbal AJ, Cooper D, Vugler A, Gittens BR, Moore A, Perretti M
The Journal of Immunology, Oxford University Press (Oup) vol. 191 (1), 171-177.  
01-07-2013
Proresolving and Tissue-Protective Actions of Annexin A1–Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor
Dalli J, Consalvo AP, Ray V, Di Filippo C, D’Amico M, Mehta N, Perretti M
The Journal of Immunology, Oxford University Press (Oup) vol. 190 (12), 6478-6487.  
15-06-2013
The role of omega-3 derived resolvins in arthritis
Norling LV, Perretti M
Current Opinion in Pharmacology, Elsevier Bv vol. 13 (3), 476-481.  
01-06-2013
SP0144 The Role of Omega-3 Derived Resolvins in Arthritis
Perretti M
Annals of The Rheumatic Diseases, Elsevier Bv vol. 72, A33-A33.  
01-06-2013
Annexin-A1 protein and its relationship to cortisol in human saliva
Fowkes RC, Moradi-Bidhendi N, Branceleone V, Zariwala MG, Brady D, Jessop DS, Perretti M, Renshaw D
Psychoneuroendocrinology, Elsevier Bv vol. 38 (5), 722-727.  
01-05-2013
Annexin 1 in microparticles promotes intestinal mucosal wound repair during inflammation. (P3264)
Nusrat A, Leoni G, Neumann P-A, Alam A, Lambeth D, Hilgarth R, Kusters D, Reutelingsperger C et al.
 
01-05-2013
Tu1993 Protective Effects of N-6 Polyunsaturated Fatty Acid Diet on Intestinal Ischemia/Reperfusion Injury Are Centererd on Lipoxin A4 and Its Receptor
Gobbetti T, Ducheix S, Faouder PL, Boue J, Bertrand-Michel J, Guillou H, Perretti M, Vergnolle N et al.
Gastroenterology, Elsevier Bv vol. 144 (5), S-899.  
01-05-2013
Resolution of inflammation: an integrated view
Ortega‐Gómez A, Perretti M, Soehnlein O
Embo Molecular Medicine, Springer Science and Business Media Llc vol. 5 (5), 661-674.  
17-04-2013
An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis
Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M et al.
Journal of Controlled Release, Elsevier Bv vol. 167 (2), 120-129.  
01-04-2013
Role of cytosolic glucocorticoid receptor and Annexin‐A1 on neutrophil traffic from bone marrow into blood: SDF‐ 1alpha/CXCR‐4/CXCR‐2 axis
Farsky SHP, Machado ID, Santin JR, Ferraz VP, Gil CD, Oliani SM, Perretti M
 
01-04-2013
Differential Trafficking of the FPR2/ALX receptor in response to endogenous or synthetic ligands
Thompson D, Perretti M
 
01-04-2013
Investigating Novel Roles for Exogenous and Endogenous Galectin‐3 in Controlling Vascular Inflammation
Gittens B, Perretti M, Cooper D
 
01-04-2013
Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis
Patel HB, Bombardieri M, Pitzalis C, Perretti M
 
01-04-2013
Omega‐3 derived Resolvin D1 reduces the severity of inflammatory arthritis
Norling LV, Perretti M
 
01-04-2013
Agonist‐induced conformational change of the Formyl Peptide Receptors
Cooray SN, Clark A, Flower R, Perretti M
 
01-04-2013
Kinin B1 receptor regulates inflammatory cell recruitment during low laminar shear stress
Martin K, Perretti M, Ahluwalia A
 
01-04-2013
Neutrophil Microparticles are heterogenous in content and function
Perretti M, Dalli J, Norling LV, Melendez TM, Hinds C
 
01-04-2013
Neutrophil‐Derived Microparticles as Novel Effectors in Joint Disease
Headland SE, Dell'Accio F, Perretti M
 
01-04-2013
Epithelial wound repair: insights into the multifaceted roles of Annexin A1
Leoni G, Neumann P, Alam A, Hilgarth RS, Lambeth DJ, Kusters D, Reutelingsperger C, Perretti M et al.
 
01-04-2013
Modulation of the receptor ALX/FPR2 in vascular inflammation
Perretti M, Bena S, Brancaleone V, Flower RJ
 
01-04-2013
Agrin expression is downregulated in OA and is required for chondrocyte differentiation
Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F
Osteoarthritis and Cartilage, Elsevier Bv vol. 21, S112-S113.  
01-04-2013
Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice
Pang J, Rhodes DH, Pini M, Akasheh RT, Castellanos KJ, Cabay RJ, Cooper D, Perretti M et al.
Plos One, Public Library of Science (Plos) vol. 8 (2), e57915-e57915.  
22-02-2013
The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class–Effect Synergy in Experimental Arthritis
Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N, Perretti M
Plos One, Public Library of Science (Plos) vol. 8 (2), e54299-e54299.  
05-02-2013
Adipose tissue‐specific modulation of galectin expression in lean and obese mice: Evidence for regulatory function
Rhodes DH, Pini M, Castellanos KJ, Montero‐Melendez T, Cooper D, Perretti M, Fantuzzi G
Obesity, Wiley vol. 21 (2), 310-319.  
01-02-2013
Smooth muscle cells in human atherosclerosis: Proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease
Viiri LE, Full LE, Navin TJ, Begum S, Didangelos A, Astola N, Berge RK, Seppälä I et al.
Journal of Molecular and Cellular Cardiology, Elsevier Bv vol. 54, 65-72.  
01-01-2013
Control of Myeloid Cell Trafficking in Resolution
Norling LV, Perretti M
Journal of Innate Immunity, S. Karger Ag vol. 5 (4), 367-376.  
01-01-2013
Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides
Ahmed TJ, Montero-Melendez T, Perretti M, Pitzalis C
International Journal of Inflammation, Wiley vol. 2013, 1-10.  
01-01-2013
Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 Expression
Sampaio ALF, Dalli J, Brancaleone V, D'Acquisto F, Perretti M, Wheatley C
Mediators of Inflammation, Wiley vol. 2013, 1-20.  
01-01-2013
Activation of annexin A1-FPR2 axis promotes resolution of house dust mite induced airway hyper-reactivity
Mathie SA, Bena S, Mondae M, Davda D, O'Donnell VB, Perretti M, Lloyd CM
 
01-01-2013
Annexin-A1 Peptide Ac2–26
Perretti M, D’Acquisto F, Flower RJ
In Handbook of Biologically Active Peptides, Elsevier 631-639.  
01-01-2013
Protective Effects of N-6 Polyunsaturated Fatty Acid Diet on Intestinal Ischemia/Reperfusion Injury Are Centererd on Lipoxin A4 and Its Receptor
Gobbetti T, Ducheix S, Le Faouder P, Boue J, Bertrand-Michel J, Guillou H, Perretti M, Vergnolle N et al.
 
01-01-2013
Chapter 86 Annexin-A1 Peptide Ac2–26
Perretti M, D’Acquisto F, Flower RJ
In Handbook of Biologically Active Peptides, Elsevier 631-639.  
01-01-2013

2012

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
Leoni G, Alam A, Neumann P-A, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 123 (1), 443-454.  
17-12-2012
Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors
Montero-Melendez T, Dalli J, Perretti M
Cell Death &Amp; Differentiation, Springer Science and Business Media Llc vol. 20 (4), 567-575.  
07-12-2012
The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis
Patel HB, Kornerup KN, Sampaio ALF, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C et al.
Annals of The Rheumatic Diseases, Elsevier Bv vol. 71 (11), 1872-1880.  
01-11-2012
Attenuation of plasma annexin A1 in human obesity
Kosicka A, Cunliffe AD, Mackenzie R, Zariwala MG, Perretti M, Flower RJ, Renshaw D
The Faseb Journal, Wiley vol. 27 (1), 368-378.  
04-10-2012
Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells
Schutters K, Kusters DHM, Chatrou MLL, Montero-Melendez T, Donners M, Deckers NM, Krysko DV, Vandenabeele P et al.
Cell Death &Amp; Differentiation, Springer Science and Business Media Llc vol. 20 (1), 49-56.  
07-09-2012
Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice
Cardini S, Dalli J, Fineschi S, Perretti M, Lungarella G, Lucattelli M
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society vol. 47 (3), 332-339.  
01-09-2012
Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci
Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 32 (8), 1970-1978.  
01-08-2012
Editorial: To resolve or not to resolve: Annexin A1 pushes resolution on track
Perretti M
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 92 (2), 245-247.  
01-08-2012
Annexin A1 Interaction with the FPR2/ALX Receptor
Bena S, Brancaleone V, Wang JM, Perretti M, Flower RJ
Journal of Biological Chemistry, Elsevier Bv vol. 287 (29), 24690-24697.  
01-07-2012
Up-Regulation of Annexin-A1 and Lipoxin A4 in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis
Vong L, Ferraz JGP, Dufton N, Panaccione R, Beck PL, Sherman PM, Perretti M, Wallace JL
Plos One, Public Library of Science (Plos) vol. 7 (6), e39244-e39244.  
18-06-2012
Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen‐induced arthritis model
Clark AK, Grist J, Al‐Kashi A, Perretti M, Malcangio M
Arthritis &Amp; Rheumatism, Wiley vol. 64 (6), 2038-2047.  
25-05-2012
Distinct localization of T cell Agrin during antigen presentation – evidence for the expression of Agrin receptor(s) in antigen‐presenting cells
Kabouridis PS, Pimentel TA, Brancaleone V, D’Acquisto F, Oliani SM, Perretti M, Jury EC
The Febs Journal, Wiley vol. 279 (13), 2368-2380.  
21-05-2012
Prednisolone exerts exquisite inhibitory properties on platelet functions
Liverani E, Banerjee S, Roberts W, Naseem KM, Perretti M
Biochemical Pharmacology, Elsevier Bv vol. 83 (10), 1364-1373.  
01-05-2012
The peritoneal tumour microenvironment of high‐grade serous ovarian cancer
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D et al.
The Journal of Pathology, Wiley vol. 227 (2), 136-145.  
18-04-2012
Mapping pathogenesis of arthritis through small animal models
Vincent TL, Williams RO, Maciewicz R, Silman A, Garside P
Rheumatology, Oxford University Press (Oup) vol. 51 (11), 1931-1941.  
16-03-2012
The effect of galectins on leukocyte trafficking in inflammation: sweet or sour?
Cooper D, Iqbal AJ, Gittens BR, Cervone C, Perretti M
Annals of The New York Academy of Sciences, Wiley vol. 1253 (1), 181-192.  
18-01-2012
Molecular engineering of short half-life small peptides (VIP, αMSH and γ3MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics
Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed M, Perretti M, Chernajovsky Y
Annals of The Rheumatic Diseases, Elsevier Bv vol. 71 (1), 143-149.  
01-01-2012
Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling
de Lima CB, Tamura EK, Montero-Melendez T, Palermo-Neto J, Perretti M, Markus RP, Farsky SHP
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 417 (2), 918-923.  
01-01-2012
Annexin A1 N-Terminal Derived Peptide Ac2-26 Exerts Chemokinetic Effects on Human Neutrophils
Dalli J, Montero-Melendez T, McArthur S, Perretti M
Frontiers in Pharmacology, Frontiers Media Sa vol. 3 
01-01-2012
The impact of endogenous annexin A1 on glucocorticoid control of in ammatory arthritis
Patel HB, Kornerup KN, Sampaio ALF, Acquisto FD, Seed MP, Girol AP, Gray M, Pitzalis C et al.
Annals of The Rheumatic Diseases vol. 71 (11), 1872-1880.  
01-01-2012
NEUTROPHIL MICROPARTICLES AS POTENTIAL NOVEL EFFECTORS OF JOINT DISEASE
Headland SE, Perretti M
 
01-01-2012
RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS
Norling L, Dalli J, Flower R, Serhan C, Perretti M
 
01-01-2012
Neutrophil microparticles as novel effectors of joint disease
Headland S, Perretti M
 
01-01-2012

2011

High density micromass cultures of a human chondrocyte cell line: A reliable assay system to reveal the modulatory functions of pharmacological agents
Greco KV, Iqbal AJ, Rattazzi L, Nalesso G, Moradi-Bidhendi N, Moore AR, Goldring MB, Dell’Accio F et al.
Biochemical Pharmacology, Elsevier Bv vol. 82 (12), 1919-1929.  
01-12-2011
Schwann cell‐specific JAM‐C‐deficient mice reveal novel expression and functions for JAM‐C in peripheral nerves
Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Carro UD, Zambroni D, Brain SD et al.
The Faseb Journal, Wiley vol. 26 (3), 1064-1076.  
16-11-2011
Activation of the Annexin A1 Pathway Underlies the Protective Effects Exerted by Estrogen in Polymorphonuclear Leukocytes
Nadkarni S, Cooper D, Brancaleone V, Bena S, Perretti M
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health) vol. 31 (11), 2749-2759.  
01-11-2011
Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3)
Di Filippo C, Perretti M, Rossi F, Ferraraccio F, Motterlini R, D’Amico M
Naunyn-Schmiedeberg's Archives of Pharmacology, Springer Science and Business Media Llc vol. 385 (2), 137-144.  
22-10-2011
Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis
Damazo AS, Sampaio ALF, Nakata CMAG, Flower RJ, Perretti M, Oliani SM
Bmc Immunology, Springer Science and Business Media Llc vol. 12 (1) 
19-10-2011
Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow
Dalli J, Jones CP, Cavalcanti DM, Farsky SH, Perretti M, Rankin SM
The Faseb Journal, Wiley vol. 26 (1), 387-396.  
28-09-2011
Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane
Ingegnoli F, Blades M, Manzo A, Wahid S, Perretti M, Panay G, Pitzalis C
Reumatismo, Pagepress Publications vol. 54 (2) 
12-09-2011
The Melanocortin Agonist AP214 Exerts Anti-Inflammatory and Proresolving Properties
Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TEN, Perretti M
The American Journal of Pathology, Elsevier Bv vol. 179 (1), 259-269.  
01-07-2011
Sphingosine-1-Phosphate Modulates Vascular Permeability and Cell Recruitment in Acute Inflammation In Vivo
Roviezzo F, Brancaleone V, De Gruttola L, Vellecco V, Bucci M, D'Agostino B, Cooper D, Sorrentino R et al.
J Pharmacol Exp Ther vol. 337 (3), 830-837.  
01-06-2011
IL-17A increases ADP-induced platelet aggregation
Maione F, Cicala C, Liverani E, Mascolo N, Perretti M, D'Acquisto F
Biochem Bioph Res Co vol. 408 (4), 658-662.  
20-05-2011
Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing
Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN
The Journal of Immunology, Oxford University Press (Oup) vol. 186 (10), 5543-5547.  
15-05-2011
Suppression of Endothelial P-Selectin Expression Contributes to Reduced Cell Trafficking in Females An Effect Independent of NO and Prostacyclin
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al.
Arterioscl Throm Vas vol. 31 (5), 1075-1083.  
01-05-2011
P54. Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex
Velmurugan S, Kapil V, McKnight AHO, Aboud Z, Davies S, Milsom AB, Pearl V, Liverani E et al.
 
01-05-2011
Evidence for an Anti-Inflammatory Loop Centered on Polymorphonuclear Leukocyte Formyl Peptide Receptor 2/Lipoxin A(4) Receptor and Operative in the Inflamed Microvasculature
Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G, Perretti M
J Immunol vol. 186 (8), 4905-4914.  
15-04-2011
Endogenous Galectin-1 and Acute Inflammation Emerging Notion of a Galectin-9 Pro-Resolving Effect
Iqbal AJ, Sampaio ALF, Maione F, Greco KV, Niki T, Hirashima M, Perretti M, Cooper D
Am J Pathol vol. 178 (3), 1201-1209.  
01-03-2011
Microvascular thrombosis and CD40/CD40L signaling
Gavins FNE, Li G, Russell J, Perretti M, Granger DN
J Thromb Haemost vol. 9 (3), 574-581.  
01-03-2011
Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation (vol 184, pg 2611, 2010)
Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC et al.
J Immunol vol. 186 (4), 2684-2685.  
15-02-2011
Cross-talk between minimally primed HL-60 cells and resting HUVEC reveals a crucial role for adhesion over extracellularly released oxidants
Allegra M, D’Acquisto F, Tesoriere L, Livrea MA, Perretti M
Biochemical Pharmacology, Elsevier Bv vol. 81 (3), 396-401.  
01-02-2011
Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids
Colucci M, Mastriota M, Maione F, Di Giannuario A, Mascolo N, Palmery M, Severini C, Perretti M et al.
Peptides, Elsevier Bv vol. 32 (2), 266-271.  
01-02-2011
Role of Melanocortin Receptors in the Regulation of Gouty Inflammation
Montero-Melendez T, Patel HB, Perretti M
Current Rheumatology Reports, Springer Science and Business Media Llc vol. 13 (2), 138-145.  
18-01-2011
Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing
Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN
Journal of Immunology vol. 186 (10), 5543-5547.  
01-01-2011
GLUCOCORTICOIDS CUT SHORT THE CONCERT OF INFLAMMATION THROUGH THE RELEASE OF ANNEXIN A1
Perretti M
 
01-01-2011
MOLECULAR ENGINEERING OF SHORT HALF LIFE SMALL PEPTIDES (VIP, αMSH AND γ3MSH) INTO LATENT ASSOCIATED PEPTIDE (LAP) RESULTS IN TARGETED ANTI-INFLAMMATORY AND ANTI-RHEUMATIC THERAPEUTICS
Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed MP, Perretti M, Chernajovsky Y
 
01-01-2011
RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS
Norling LV, Dalli J, Serhan CN, Perretti M
 
01-01-2011
GALECTIN-9: SWEETENING LEUKOCYTE RECRUITMENT
Cooper D, Iqbal AJ, Niki T, Hirashima M, Perretti M
 
01-01-2011
ENDOGENOUS GALECTIN-1 INHIBITS EXPERIMENTAL ARTHRITIS: A POTENTIAL SWEET THERAPEUTIC TARGET?
Iqbal AJ, Cooper D, Vugler AD, Moore A, Perretti M
 
01-01-2011
EXPRESSION OF ANNEXIN A1 IN ADIPOSE TISSUE IS DISSOCIATED FROM MACROPHAGE INFILTRATION DURING DEVELOPMENT OF OBESITY IN MICE
Rhodes D, Pini M, Montero-Melendez T, Perretti M, Fantuzzi G
 
01-01-2011
MC3 AGONISTS AS NOVEL PRO-RESOLVING THERAPEUTICS
Montero-Melendez T, Jonassen T, Seed M, Perretti M
 
01-01-2011
MELANOCORTIN RECEPTOR AGONISTS ARE NOVEL CHONDROPROTECTIVE THERAPEUTICS
Greco KV, Montero-Melendez T, Patel H, Perretti M
 
01-01-2011
3D CULTURES OF C-28/I2 CHONDROCYTES TO STUDY CHONDROCYTE BIOLOGY AND THERAPEUTIC DEVELOPMENT
Greco KV, Moore A, Dell'Accio F, Perretti M
 
01-01-2011
A NOVEL CROSS-TALK IN RESOLUTION: H2S ACTIVATES THE ANNEXIN A1 PATHWAY
Brancaleone V, Sampaio AL, Cirino G, Flower RJ, Perretti M
 
01-01-2011
Annexin-A1: A Potential Novel Biomarker in Giant Cell Arteritis.
Nadkarni S, Hollywood J, Mason JC, Dasgupta B, Perretti M
 
01-01-2011
Melanocortin Receptors as Novel Effectors of Macrophage Responses in Inflammation
Patel HB, Montero-Melendez T, Greco KV, Perretti M
Frontiers in Immunology, Frontiers Media Sa vol. 2 
01-01-2011
Melanocortin receptors as novel effectors of macrophage responses in inflammation.
Patel HB, Montero-Melendez T, Greco KV, Perretti M
Frontiers in Immunology vol. 2 
01-01-2011
Intra-articular delivery of salmon calcitonin nanocomplexes to the K/BXN murine model for treatment of osteoarthritis
Ryan SM, Patel HB, Kornerup KN, Tajber L, Umerska A, Perretti M, Brayden DJ
 
01-01-2011
An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse
Pimentel TA, Sampaio ALF, D'Acquisto F, Perretti M, Oliani SM
Lab Invest vol. 91 (1), 33-42.  
01-01-2011
Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets
Spurr L, Nadkarni S, Pederzoli-Ribeil M, Goulding NJ, Perretti M, D'Acquisto F
Int Immunopharmacol vol. 11 (1), 55-66.  
01-01-2011

2010

Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4(-)CD8(-) T cells
Maione F, Paschalidis N, Iqbal AJ, Crompton T, Perretti M, D'Acquisto F
Autoimmunity vol. 43 (8), 672-681.  
01-12-2010
Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al.
Faseb J vol. 24 (12), 4835-4843.  
01-12-2010
Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature
Pederzoli-Ribeil M, Maione F, Cooper D, Al-Kashi A, Dalli J, Perretti M, D'Acquisto F
Blood vol. 116 (20), 4288-4296.  
18-11-2010
FPR2/ALX receptor expression and internalization are critical for lipoxin A(4) and annexin-derived peptide-stimulated phagocytosis
Maderna P, Cottell DC, Toivonen T, Dufton N, Dalli J, Perretti M, Godson C
Faseb J vol. 24 (11), 4240-4249.  
01-11-2010
Human RCAN3 gene expression and cell growth in endothelial cells
Canaider
International Journal of Molecular Medicine, Spandidos Publications vol. 26 (6) 
21-10-2010
561 THE CINOD NCX 429 INHIBITS MICROVASCULAR INFLAMMATION THROUGH ITS NO-RELEASING PROPERTIES
Perretti M, Dalli J, Bolla M, Padron J
 
01-10-2010
Downstream Gene Activation of the Receptor ALX by the Agonist Annexin A1
Renshaw D, Montero-Melendez T, Dalli J, Kamal A, Brancaleone V, D'Acquisto F, Cirino G, Perretti M
Plos One vol. 5 (9) 
17-09-2010
Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization.
Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M, Flower RJ
Arterioscler Thromb Vasc Biol vol. 30 (9), 1718-1724.  
01-09-2010
Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis
Patel HB, Bombardieri M, Sampaio ALF, D’Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C et al.
The Faseb Journal, Wiley vol. 24 (12), 4835-4843.  
11-08-2010
Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists
Dufton N, Perretti M
Pharmacol Therapeut vol. 127 (2), 175-188.  
01-08-2010
Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis
Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M
J Leukocyte Biol vol. 87 (5), 877-884.  
01-05-2010
The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature
Leoni G, Voisin MB, Carlson K, Getting SJ, Nourshargh S, Perretti M
Brit J Pharmacol vol. 160 (1), 171-180.  
01-05-2010
The cardio-protective properties of NCX-6550, a nitric oxide donating pravastatin, in the mouse
Di Filippo C, Monopoli A, Ongini E, Perretti M, D’Amico M
Microcirculation, Wiley 
01-04-2010
Human β‐defensin 3 has immunosuppressive activity in vitro and in vivo
Semple F, Webb S, Li H, Patel HB, Perretti M, Jackson IJ, Gray M, Davidson DJ et al.
European Journal of Immunology, Wiley vol. 40 (4), 1073-1078.  
01-04-2010
Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation
Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC et al.
J Immunol vol. 184 (5), 2611-2619.  
01-03-2010
Enhanced neutrophil expression of annexin-1 in coronary artery disease
Särndahl E, Bergström I, Nijm J, Forslund T, Perretti M, Jonasson L
Metabolism, Elsevier Bv vol. 59 (3), 433-440.  
01-03-2010
Role of endogenous Annexin-A1 in the regulation of thymocyte positive and negative selection
Paschalidis N, Huggins A, Rowbotham NJ, Furmanski AL, Crompton T, Flower RJ, Perretti M, D’Acquisto F
Cell Cycle, Informa Uk Limited vol. 9 (4), 785-794.  
15-02-2010
Melanocortin Control of Cell Trafficking in Vascular Inflammation
Patel HB, Leoni G, Melendez TM, Sampaio ALF, Perretti M
In Advances in Experimental Medicine and Biology, Springer New York 88-106.  
01-01-2010
Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands
Hunter C, Kadakia TB, Cooper D, Perretti M, Schwartz RC, Brown SB
The Scientific World Journal, Wiley vol. 10, 1580-1596.  
01-01-2010
\Super\ Annexin-A1: a novel tool to regulate neutrophil-driven inflammation?
Pederzoli-Ribeil M, Maione F, Al-Kashi A, Dalli J, Perretti M, D'Acquisto F
 
01-01-2010
Mobilization of Annexin A1 in human polymorphonuclear leukocytes (PMN)
Brancaleone V, Dalli J, Perretti M
 
01-01-2010
Abnormalities in annexin a1 null bone marrow cells: evidence for failure of clearance of apoptotic neutrophils
Dalli J, Cavalcanti DM, Farksy SH, Rankin S, Flower RJ, Perretti M
 
01-01-2010
CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway
Dalli J, Rosignoli G, Hayhoe RPG, Edelman A, Perretti M
American Journal of Pathology vol. 177 (1), 176-186.  
01-01-2010
MULTIPLE FUNCTIONAL TARGETS OF THE IMMUNOREGULATORY ACTIVITY OF GALECTIN-1: CONTROL OF IMMUNE CELL TRAFFICKING, DENDRITIC CELL PHYSIOLOGY, AND T-CELL FATE
Cooper D, Ilarregui JM, Pesoa SA, Croci DO, Perretti M, Rabinovich GA
199-244.  
01-01-2010
Human RCAN3 gene expression and cell growth in endothelial cells
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D, Perretti M
International Journal of Molecular Medicine vol. 26 (6), 913-918.  
01-01-2010
Protective effect of oestrogen is mediated by the anti-inflammatory protein annexin-A1
Nadkarni S, Brancaleone V, Bena S, Perretti M
 
01-01-2010

2009

Modulation of experimental autoimmune encephalomyelitis by endogenous Annexin A1
Paschalidis N, Iqbal AJ, Maione F, Wood EG, Perretti M, Flower RJ, D'Acquisto F
J Neuroinflamm vol. 6 
13-11-2009
Laminar Shear Stress Regulates Endothelial Kinin B1 Receptor Expression and Function Potential Implication in Atherogenesis
Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P et al.
Arterioscl Throm Vas vol. 29 (11), 1757-1763.  
01-11-2009
Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics
Perretti M, Dalli J
Brit J Pharmacol vol. 158 (4), 936-946.  
01-10-2009
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M et al.
Nature, Springer Science and Business Media Llc vol. 461 (7268), 1287-1291.  
01-10-2009
297 INVESTIGATION OF THE ROLE OF FORMYL PEPTIDE RECEPTOR IN ACUTE NOCICEPTION USING GENE‐DEFICIENT MICE
Pieretti S, di Giannuario A, Colucci M, Mastriota M, Perretti M
European Journal of Pain, Wiley vol. 13 (S1) 
01-09-2009
Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages
McColl A, Bournazos S, Franz S, Perretti M, Morgan BP, Haslett C, Dransfield I
The Journal of Immunology, Oxford University Press (Oup) vol. 183 (3), 2167-2175.  
01-08-2009
Quantitative Analysis of Promoter Activity by Green Fluorescent Protein (GFP) Target/Reporter Strategy in a Novel Transgenic alx/fpr-rs2 Null Mouse
Dufton NP, Hannon R, Perretti M, Flower R
Inflammation Research, Springer Science and Business Media Llc vol. 58 (S2), S252-S255.  
01-07-2009
Endogenous galectins and the control of the host inflammatory response
Norling LV, Perretti M, Cooper D
J Endocrinol vol. 201 (2), 169-184.  
01-05-2009
Activation of PPARβ/δ inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release
Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y, Bishop-Bailey D
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 86 (1), 115-122.  
23-04-2009
Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation
Huggins A, Paschalidis N, Flower RJ, Perretti M, D'Acquisto F
Faseb J vol. 23 (4), 985-996.  
01-04-2009
Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: An in vivo study
Tripatara P, Patel NSA, Brancaleone V, Renshaw D, Rocha J, Sepodes B, Mota-Filipe H, Perretti M et al.
Eur J Pharmacol vol. 606 (1-3), 205-209.  
15-03-2009
Interleukin 17 sustains rather than induces inflammation
Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, Dacquisto F
Biochem Pharmacol vol. 77 (5), 878-887.  
01-03-2009
A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects
Hecht I, Rong J, Sampaio ALF, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M et al.
The Journal of Pharmacology and Experimental Therapeutics, Elsevier Bv vol. 328 (2), 426-434.  
01-02-2009
Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation
Gastardelo TS, Damazo AS, Dalli J, Flower RJ, Perretti M, Oliani SM
The American Journal of Pathology, Elsevier Bv vol. 174 (1), 177-183.  
01-01-2009
A role for α5β1 integrin in leukocyte accumulation in acute peritonitis
Sampaio ALF, Leoni G, Marshall JF, Perretti M
 
01-01-2009
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
Perretti M, D'Acquisto F
Nat Rev Immunol vol. 9 (1), 62-70.  
01-01-2009
Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis
Patel HB, Bombardieri M, Pitzalis C, Perretti M
European Journal of Clinical Investigation vol. 39, 29-29.  
01-01-2009
The impact of Annexin-A1 cleavage on neutrophil behaviour during vascular inflammation
Pederzoli-Ribeil M, Maione F, Perretti M, D'Acquisto F
European Journal of Clinical Investigation vol. 39, 37-37.  
01-01-2009
Annexin-A1, a novel pathway effector of neutrophil behavior in Wegener disease?
Pederzoli-Ribeil M, Maione F, Perretti M, D'Acquisto F
 
01-01-2009
Annexin A1 regulates intestinal mucosal injury, inflammation, and repair
Laukoetter MG, Babbin BA, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA et al.
In Deutsche Gesellschaft FüR Chirurgie, Springer Berlin Heidelberg 225-227.  
01-01-2009
The role of ALX/FPRL-1 in inflammation and its impact on Annexin A1 biology
Perretti M, Dufton N, Patel HB, Hannon R, Flower RJ
 
01-01-2009

2008

A role for MC3R in modulating lung inflammation
Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M, Spina D
Pulmonary Pharmacology &Amp; Therapeutics, Elsevier Bv vol. 21 (6), 866-873.  
01-12-2008
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion
Leoni G, Patel HB, Sampaio ALF, Gavins FNE, Murray JF, Grieco P, Getting SJ, Perretti M
Faseb J vol. 22 (12), 4228-4238.  
01-12-2008
Annexin A1 Regulates Intestinal Mucosal Injury, Inflammation, and Repair
Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 181 (7), 5035-5044.  
01-10-2008
Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation
Oliani SM, Ciocca GAP, Pimentel TA, Damazo AS, Gibbs L, Perretti M
Inflammation Research, Springer Science and Business Media Llc vol. 57 (10), 450-456.  
01-10-2008
Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles
Dalli J, Norling LV, Renshaw D, Cooper D, Leung K-Y, Perretti M
Blood, American Society of Hematology vol. 112 (6), 2512-2519.  
15-09-2008
Annexin‐A1: a pivotal regulator of the innate and adaptive immune systems
D'Acquisto F, Perretti M, Flower RJ
British Journal of Pharmacology, Wiley vol. 155 (2), 152-169.  
01-09-2008
Overview of the Role of Annexin 1 in the Innate and Adaptive Immune Response
D'Acquisto F, Perretti M
Immunology‚ Endocrine &Amp; Metabolic Agents in Medicinal Chemistry, Bentham Science Publishers Ltd. vol. 8 (3), 252-258.  
01-09-2008
Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4(+) T cells
D'Acquisto F, Paschalidis N, Raza K, Buckley CD, Flower RJ, Perretti M
Rheumatology vol. 47 (5), 636-639.  
01-05-2008
ENHANCED NEUTROPHIL EXPRESSION OF ANNEXIN-1 IN CORONARY ARTERY DISEASE
Sarndahl E, Bergstrom I, Nijm J, Perretti M, Jonasson L
Atherosclerosis Supplements, Elsevier Bv vol. 9 (1), 15-15.  
01-05-2008
Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow
Cooper D, Norling LV, Perretti M
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 83 (6), 1459-1466.  
27-03-2008
Annexin-1 modulates repair of gastric mucosal injury
Martin GR, Perretti M, Flower RJ, Wallace JL
American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society vol. 294 (3), G764-G769.  
01-03-2008
Altered expression of annexin 1 and its receptor in neutrophils of patients with giant cell arteritis (GCA) and ANCA associated vasculitis (AAV)
Dasgupta B, Dalli J, Norling L, Pederzoli-Ribeil M, Hollywood J, D'Acquisto F, Perretti M
 
01-01-2008
Initial characterisation of the novel transgenic, the alx/fpr-rs2 null mouse
Dufton N, Buckingham J, Perretti M, Flower R
Fundamental & Clinical Pharmacology vol. 22, 48-48.  
01-01-2008

2007

Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion
Finney SJ, Anning PB, Cao TV, Perretti M, Evans TW, Burke-Gaffney A
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 364 (4), 831-837.  
01-12-2007
Inhibitory control of endothelial galectin‐1 onin vitroandin vivolymphocyte trafficking
Norling LV, Sampaio ALF, Cooper D, Perretti M
The Faseb Journal, Wiley vol. 22 (3), 682-690.  
26-10-2007
Aromatic Lipoxin A4and Lipoxin B4Analogues Display Potent Biological Activities
O'Sullivan TP, Vallin KSA, Ali Shah ST, Fakhry J, Maderna P, Scannell M, Sampaio ALF, Perretti M et al.
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 50 (24), 5894-5902.  
26-10-2007
Impaired T cell activation and increased Th2 lineage commitment in Annexin‐1‐deficient T cells
D'Acquisto F, Paschalidis N, Sampaio ALF, Merghani A, Flower RJ, Perretti M
European Journal of Immunology, Wiley vol. 37 (11), 3131-3142.  
24-10-2007
Ligation of the adhesion‐GPCR EMR2 regulates human neutrophil function
Yona S, Lin H, Dri P, Davies JQ, Hayhoe RPG, Lewis SM, Heinsbroek SEM, Brown KA et al.
The Faseb Journal, Wiley vol. 22 (3), 741-751.  
10-10-2007
Potential of calcitonin as a novel cotreatment for arthritis
Perretti M, Mancini L
Future Rheumatology, Omics Publishing Group vol. 2 (5), 493-496.  
01-10-2007
A novel inflammatory pathway recruitment: Role for the kinin chemokine CXCL5
Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A
J Immunol vol. 179 (7), 4849-4856.  
01-10-2007
Annexin 1 Cleavage in Activated Neutrophils
Vong L, D'Acquisto F, Pederzoli-Ribeil M, Lavagno L, Flower RJ, Witko-Sarsat V, Perretti M
Journal of Biological Chemistry, Elsevier Bv vol. 282 (41), 29998-30004.  
01-10-2007
Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation
Gavins FNE, Dalli J, Flower RJ, Granger DN, Perretti M
Faseb J vol. 21 (8), 1751-1758.  
01-06-2007
Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow
Urquhart P, Rosignoli G, Cooper D, Motterlini R, Perretti M
J Pharmacol Exp Ther vol. 321 (2), 656-662.  
01-05-2007
Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides
John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E et al.
Faseb J vol. 21 (4), 1037-1046.  
01-04-2007
Uneven modulation of the annexin 1 system in osteoblast-like cells by dexamethasone
Giner RM, Mancini L, Kamal AM, Perretti M
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 354 (2), 414-419.  
01-03-2007
Calcitonin and Prednisolone Display Antagonistic Actions on Bone and Have Synergistic Effects in Experimental Arthritis
Mancini L, Paul-Clark MJ, Rosignoli G, Hannon R, Martin JE, Macintyre I, Perretti M
The American Journal of Pathology, Elsevier Bv vol. 170 (3), 1018-1027.  
01-03-2007
Glucocorticoids in innate immunity: more transactivation than transrepression!
Perretti M
Blood, American Society of Hematology vol. 109 (3), 852-853.  
01-02-2007
Resolution of in flammation: state of the art, definitions and terms
Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LAJ, Perretti M, Rossi AG et al.
The Faseb Journal, Wiley vol. 21 (2), 325-332.  
01-02-2007
Annexin-1 modulates T-cell activation and differentiation
D'Acquisto F, Merghani A, Lecona E, Rosignoli G, Raza K, Buckley CD, Flower RJ, Perretti M
Blood vol. 109 (3), 1095-1102.  
01-02-2007
PPARb inhibits neutrophil-endothelium interactions under flow
Piqueras L, Norlyng L, Perretti M, Li Y, Sanz MJ, Real JT, Warner T, Bishop-Bayley D
 
01-01-2007

2006

[d-Trp8]-γ-Melanocyte-Stimulating Hormone Exhibits Anti-Inflammatory Efficacy in Mice Bearing a Nonfunctional MC1R (Recessive Yellow e/e Mouse)
Getting SJ, Lam CW, Leoni G, Gavins FNE, Grieco P, Perretti M
Molecular Pharmacology, Elsevier Bv vol. 70 (6), 1850-1855.  
01-12-2006
Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes
Sawmynaden P, Perretti M
Biochem Bioph Res Co vol. 349 (4), 1351-1355.  
03-11-2006
Therapeutic Exploitation of Endogenous Anti-Inflammatory Mechanisms:Old and New Leads
Renshaw D, Urquhart P, Perretti M
Anti-Inflammatory &Amp; Anti-Allergy Agents in Medicinal Chemistry, Bentham Science Publishers Ltd. vol. 5 (4), 289-305.  
01-11-2006
Melanocortin 3 receptors control crystal‐induced inflammation
Getting SJ, Lam CW, Chen AS, Grieco P, Perretti M
The Faseb Journal, Wiley vol. 20 (13), 2234-2241.  
01-11-2006
Antiflammin-2 activates the human formyl-peptide receptor like 1.
Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E, Perretti M
Scientificworldjournal vol. 6, 1375-1384.  
25-10-2006
ImmunomodulationThe promises of immunopharmacology for the development of new drugs
CASSATELLA M, PERRETTI M
Current Opinion in Pharmacology, Elsevier Bv vol. 6 (4), 376-378.  
01-08-2006
Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors
Babbin BA, Lee WY, Parkos CA, Winfree LM, Akyildiz A, Perretti M, Nusrat A
J Biol Chem vol. 281 (28), 19588-19599.  
14-07-2006
Impaired phagocytic mechanism in annexin 1 null macrophages
Yona S, Heinsbroek SEM, Peiser L, Gordon S, Perretti M, Flower RJ
British Journal of Pharmacology, Wiley vol. 148 (4), 469-477.  
01-06-2006
Novel Aspects of Annexin 1 and Glucocorticoid Biology: Intersection with Nitric Oxide and the Lipoxin Receptor
Perretti M, D'Acquisto F
Inflammation &Amp; Allergy-Drug Targets, Bentham Science Publishers Ltd. vol. 5 (2), 107-114.  
01-04-2006
Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin‐1 and galectin‐3
Gil CD, La M, Perretti M, Oliani SM
Cell Biology International, Wiley vol. 30 (4), 338-344.  
01-04-2006
Spatial and Temporal Profiles for Anti-Inflammatory Gene Expression in Leukocytes during a Resolving Model of Peritonitis
Damazo AS, Yona S, Flower RJ, Perretti M, Oliani SM
The Journal of Immunology, Oxford University Press (Oup) vol. 176 (7), 4410-4418.  
01-04-2006
Glueocorticoid regulated expression of the anti-inflammatory receptor ALXR.
Renshaw D, Sawmynadan P, Dalli J, Perretti M
 
06-03-2006
The anti‐adhesive effects of annexin 1 on neutrophil‐endothelial interactions under flow
Hayhoe RPG, Cooper D, Perretti M
 
01-03-2006
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement
Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D, Perretti M
Blood vol. 107 (5), 2123-2130.  
01-03-2006
Annexin I regulates epithelial cell migration by signaling through formyl peptide receptors
Babbin BA, Lee W, Winfree LM, Akyildiz A, Parkos CA, Perretti M, Nusrat A
 
01-03-2006
Inflammation-induced modulation of cellular galectin-1 and-3 expression in a model of rat peritonitis
Gil CD, Cooper D, Rosignoli G, Perretti M, Oliani SM
Inflamm Res vol. 55 (3), 99-107.  
01-03-2006
Cleavage of Annexin‐A1 by Proteinase 3: a possible cause of Wegener’s vasculitis?
Vong L, D’Acquisto F, Flower RJ, Witko‐Sarsat V, Perretti M
 
01-03-2006
Endogenous Galectn‐1 inhibits lymphocyte‐endothelial cell interactions as determined by small interference RNA
Norling LV, Cooper D, Perretti M
 
01-03-2006
INFLAMMATORY CHEMOKINE CXCL5 EXPRESSION BY ENDOTHELIAL CELLS IS DEPENDENT UPON KININ B1 RECEPTOR ACTIVATION
Duchene J, Lecomte F, Perretti M, Ahluwalia A
 
01-03-2006
Disinct patterns of gene expression induced by annexin 1 activation of the ALXR receptor in HEK293 cells.
Renshaw D, Dalli J, Kamal A, Perretti M
 
01-03-2006
The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage
Getting SJ, Di Filippo C, D'Amico M, Perretti M
European Journal of Pharmacology, Elsevier Bv vol. 532 (1-2), 138-144.  
01-02-2006
Melanocortin receptor signaling in RAW264.7 macrophage cell line
Lam CW, Perretti M, Getting SJ
Peptides vol. 27 (2), 404-412.  
01-02-2006
Annexin A1: a novel target of the immunosuppressive effects of glucocorticoids in autoimmune diseases
D'Acquisto F, Merghani A, Lecona E, Guglielmo R, Vo P, Raza K, Buckley C, Flower RJ et al.
 
01-01-2006
A role for MC3R in modulating eosinophil migration in allergic inflammation
Perretti M, GETTING SJ, Spina D, Riffo-Vasquez Y, Page C, Pitchford S, Grieco P
 
01-01-2006
Anti-inflammatory and analgesic aspects of the annexin A1 system
Flower RJ, Ayoub S, Perretti M
Acta Pharmacologica Sinica vol. 27 (9), 1272-1272.  
01-01-2006
Indicaxanthin and betanin suppress LPS-induced NF-κB activation and modulate the levels of inflammatory mediators iNOS, COX-2 and PGE2 in macrophages.
Allegra M, Tesoriere L, D'acquisto F, Perretti M, Livrea M
 
01-01-2006
CO-releasing molecules modulate leukocyte/endothelial cell adhesion: under static and flow studies
Urquhart P, Cooper D, Motterlini R, Perretti M
 
01-01-2006
Annexin 1, anti-inflammatory drugs and the neuroendocrine-immune interface.
Flower RJ, Perretti M, D'Acquisto F, Buckingham JC
Acta Pharmacologica Sinica vol. 27, 13-14.  
01-01-2006

2005

Ligand-specific glucocorticoid receptor activation in human platelets
Moraes LA, Paul-Clark MJ, Rickman A, Flower RJ, Goulding NJ, Perretti M
Blood vol. 106 (13), 4167-4175.  
15-12-2005
Down-regulation of the Anti-inflammatory Protein Annexin A1 in Cystic Fibrosis Knock-out Mice and Patients
Bensalem N, Ventura AP, Vallée B, Lipecka J, Tondelier D, Davezac N, Santos AD, Perretti M et al.
Molecular &Amp; Cellular Proteomics, Elsevier Bv vol. 4 (10), 1591-1601.  
01-10-2005
A twist in anti-inflammation: Annexin 1 acts via the lipoxin A(4) receptor
Gavins FNE, Sawmynaden P, Chatterjee BE, Perretti M
Prostag Leukotr Ess vol. 73 (3-4), 211-219.  
01-09-2005
Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro
Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ, Perretti M
J Leukocyte Biol vol. 78 (3), 639-646.  
01-09-2005
Aspirin and steroids: new mechanistic findings and avenues for drug discovery
GILROY D, PERRETTI M
Current Opinion in Pharmacology, Elsevier Bv vol. 5 (4), 405-411.  
01-08-2005
A novel role for Annexin 1 in macrophage phagocytosis
Yona S, Heinsbroek S, Gordon S, Perretti M, Flower RJ
Inflammation Research, Springer Science and Business Media Llc vol. 54 (S2), S217-S218.  
01-08-2005
Role of the Immune system in chronic pain
Marchand F, Perretti M, McMahon SB
Nature Reviews Neuroscience, Springer Science and Business Media Llc vol. 6 (7), 521-532.  
01-07-2005
A novel effect for annexin 1-derived peptide Ac2-26: Reduction of allergic inflammation in the rat
Bandeira-Melo C, Bonavita AGC, Diaz BL, Silva PMRE, Carvalho VF, Jose PJ, Flower RJ, Perretti M et al.
J Pharmacol Exp Ther vol. 313 (3), 1416-1422.  
01-06-2005
Critical Protective Role for Annexin 1 Gene Expression in the Endotoxemic Murine Microcirculation
Damazo AS, Yona S, D'Acquisto F, Flower RJ, Oliani SM, Perretti M
The American Journal of Pathology, Elsevier Bv vol. 166 (6), 1607-1617.  
01-06-2005
Modulation of Phagocytosis of Apoptotic Neutrophils by Supernatant from Dexamethasone-Treated Macrophages and Annexin-Derived Peptide Ac2–26
Maderna P, Yona S, Perretti M, Godson C
The Journal of Immunology, Oxford University Press (Oup) vol. 174 (6), 3727-3733.  
15-03-2005
Controlling inflammation: a fat chance?
Flower RJ, Perretti M
J Exp Med vol. 201 (5), 671-674.  
07-03-2005
Inhibitory control of TGF‐β1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes
Basoni C, Nobles M, Grimshaw A, Desgranges C, Davies D, Perretti M, Kramer IM, Genot E
The Faseb Journal, Wiley vol. 19 (7), 1-25.  
03-03-2005
An overview of the effects of annexin 1 on cells involved in the inflammatory process
Kamal AM, Flower RJ, Perretti M
Memorias Do Instituto Oswaldo Cruz vol. 100, 39-47.  
01-03-2005
Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage
Zanardo RCO, Perretti M, Wallace JL
American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society vol. 288 (3), G481-G486.  
01-03-2005
In Vitro and In Vivo Induction of Heme Oxygenase 1 in Mouse Macrophages following Melanocortin Receptor Activation
Lam CW, Getting SJ, Perretti M
The Journal of Immunology, Oxford University Press (Oup) vol. 174 (4), 2297-2304.  
15-02-2005
Macrophage biology in the Anx-A1(-/-) mouse
Yona S, Ward B, Buckingham JC, Perretti M, Flower RJ
Prostaglandins Leukotrienes and Essential Fatty Acids vol. 72 (2), 95-103.  
01-02-2005
Critical protective role for annexin 1 gene expression in mouse endotoxemia
Perretti M, Damazo AS, Yona S, D'acquisto F, Oliani SM, Flower RJ
 
01-01-2005
MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct
Perretti M, Lam CW, Getting SJ, Di Filippo C, D'Amico M
 
01-01-2005
Galectin-1 inhibits neutrophil rolling in a carbohydrate-dependent manner
Cooper D, Perretti M
 
01-01-2005
Calcitonin abolishes collagen-induced arthritis.
MacIntyre I, Mancini L, Perretti M
 
01-01-2005
Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in marine acute myocardial infarct
Perretti M, Gavins FNE, Kamal AM, D'Amico M, Oliani SM
 
01-01-2005
Effect of annexin 1 in an in vitro model of human neutrophil-endothelial interaction under flow
Cooper D, Hayhoe RPG, Perretti M
 
01-01-2005
Interaction of annexin 1 (Anx-A1) and its bioactive peptides with receptors of the human FPR family
Kamal AM, Sawmynaden P, Perretti M
 
01-01-2005
Higher degree of neutrophil activation in vitro and within the microcirculation in absence of annexin 1 (Anx-A1) gene
Perretti M, Chatterjee BE, Yona S, Flower RJ
 
01-01-2005
An overview of the effects of annexin 1 on cells involved in the inflammatory process
Kamal AM, Flower RJ, Perretti M
 
01-01-2005
In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation
Perretti M, Lam CW, Getting SJ
 
01-01-2005
Chemokine involvement in kinin B1 receptor-mediated leukocyte recruitment
Duchene J, Perretti M, Ahluwalia A
 
01-01-2005
The inhibition of neutrophil-endothelial cell adhesion by hyaluronan independent of CD44
Alam CAS, Seed MP, Freemantle C, Brown J, Perretti M, Carrier M, Divwedi A, West DC et al.
Inflammopharmacology, Springer Science and Business Media Llc vol. 12 (5-6), 535-550.  
01-01-2005
Calcitonin (CT) and glucocorticoids (GC) have contrasting effects on the RANKL/OPG system in osteoblast-like cells
Perretti M, Mancini L, Paul-Clark MJ, Hannon R, Macintyre I
 
01-01-2005
A novel role for Annexin 1 in macrophage phagocytosis
Yona S, Heinsbroek S, Gordon S, Perretti M, Flow RJ
 
01-01-2005
Annexin 1 Peptide Protects against Focal Cerebral Ischaemia-Reperfusion Injury in Mice
Gavins FN, Granger N, Perretti M
 
01-01-2005

2004

Inhibitory Effects of TSG‐6 Link Module on Leukocyte–Endothelial Cell Interactions In Vitro and In Vivo
CAO TV, LA M, GETTING SJ, DAY AJ, PERRETTI M
Microcirculation, Wiley vol. 11 (7), 615-624.  
11-10-2004
MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct
Getting SJ, Di Filippo C, Christian HC, Lam CW, Rossi F, D'Amico M, Perretti M
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 76 (4), 845-853.  
01-10-2004
Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct
Gavins FNE, Kamal AM, D'Amico M, Oliani SM, Perretti M
Faseb J vol. 18 (13), 100-+.  
01-10-2004
The Distinct Alterations Produced in Cardiovascular Functions by Prednisolone and Nitro-prednisolone (NCX-1015) in the Rat Highlight a Causal Role for Endothelin-1
Di Filippo C, Rossi F, Ongini E, Del Soldato P, Perretti M, D’Amico M
The Journal of Pharmacology and Experimental Therapeutics, Elsevier Bv vol. 310 (3), 1133-1141.  
01-09-2004
Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages
Yona S, Buckingham JC, Perretti M, Flower RJ
Brit J Pharmacol vol. 142 (5), 890-898.  
01-07-2004
Annexin 1 and the biology of the neutrophil
Perretti M, Flower RJ
Journal of Leukocyte Biology vol. 76 (1), 25-29.  
01-07-2004
The Annexin 1-/- Mouse: Phenotypic Studies
MARTIN JE, Flower RJ, Perretti M, Hannon R, Getting SJ, Gavins FNE, Christian HC, Parente L et al.
Annexins vol. 1 (2), 109-120.  
01-07-2004
Annexin 1 and neutrophil apoptosis
Perretti M, Solito E
Biochemical Society Transactions vol. 32, 507-510.  
01-06-2004
Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides
Pieretti S, Di Giannuario A, De Felice M, Perretti M, Cirino G
Pain, Ovid Technologies (Wolters Kluwer Health) vol. 109 (1), 52-63.  
01-05-2004
Inflammatory resolution: New opportunities for drug discovery
Gilroy DW, Lawrence T, Perretti M, Rossi AG
Nat Rev Drug Discov vol. 3 (5), 401-416.  
01-05-2004
Neutrophil Elastase (NE)-Deficient Mice Demonstrate a Nonredundant Role for NE in Neutrophil Migration, Generation of Proinflammatory Mediators, and Phagocytosis in Response to Zymosan Particles In Vivo
Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M, Nourshargh S
The Journal of Immunology, Oxford University Press (Oup) vol. 172 (7), 4493-4502.  
01-04-2004
Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen‐induced arthritis
Yang YH, Morand EF, Getting SJ, Paul‐Clark M, Liu DL, Yona S, Hannon R, Buckingham JC et al.
Arthritis &Amp; Rheumatism, Wiley vol. 50 (3), 976-984.  
01-03-2004
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 101 (5), 1386-1391.  
23-01-2004
An isocratic HPLC method for the quantitation of eicosanoids in human platelets
Moraes LA, Giner RM, Paul‐Clark MJ, Perretti M, Perrett D
Biomedical Chromatography, Wiley vol. 18 (1), 64-68.  
01-01-2004
Analysis of annexin 1 expression in rat trachea: study of mast cell heterogeneity.
PERRETTI M, Oliani SM, Takahashi HK, Damazo AS, Paul-Clark MJ, Straus AH
Annexins vol. 1, 12-18.  
01-01-2004
Pan-selectin glycomimetic inhibitors inhibit rolling and neutrophil migration in mouse models of inflammation
Smith T, Perretti M, Patton JT, Sarkar A, Magnani JL
 
01-01-2004

2003

Synthesis of Nitro Esters of Prednisolone, New Compounds Combining Pharmacological Properties of Both Glucocorticoids and Nitric Oxide
Baraldi PG, Romagnoli R, del Carmen Nuñez M, Perretti M, Paul-Clark MJ, Ferrario M, Govoni M, Benedini F et al.
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 47 (3), 711-719.  
20-12-2003
The annexin 1 receptor(s): is the plot unravelling?
Perretti M
Trends in Pharmacological Sciences, Elsevier Bv vol. 24 (11), 574-579.  
01-11-2003
A Novel Biological Activity for Galectin-1
La M, Cao TV, Cerchiaro G, Chilton K, Hirabayashi J, Kasai K-I, Oliani SM, Chernajovsky Y et al.
The American Journal of Pathology, Elsevier Bv vol. 163 (4), 1505-1515.  
01-10-2003
Glucocorticoid Receptor Nitration Leads to Enhanced Anti-Inflammatory Effects of Novel Steroid Ligands
Paul-Clark MJ, Roviezzo F, Flower RJ, Cirino G, Soldato PD, Adcock IM, Perretti M
The Journal of Immunology, Oxford University Press (Oup) vol. 171 (6), 3245-3252.  
15-09-2003
Dissection of the Anti-Inflammatory Effect of the Core and C-Terminal (KPV) α-Melanocyte-Stimulating Hormone Peptides
Getting SJ, Schiöth HB, Perretti M
The Journal of Pharmacology and Experimental Therapeutics, Elsevier Bv vol. 306 (2), 631-637.  
01-08-2003
The enhanced anti-inflammatory properties of nitro-prednisolone (NCX-1015) is linked to post-translational modification of the glucocorticoid receptor
Paul-Clark MJ, Perretti M
 
01-07-2003
A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils
Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S, Perretti M
Faseb J vol. 17 (9), 1544-+.  
01-06-2003
Leukocyte antiadhesive actions of annexin 1: ALYR- and FPR-related anti-inflammatory mechanisms
Gavins FNE, Yona S, Kamal AM, Flower RJ, Perretti M
Blood vol. 101 (10), 4140-4147.  
15-05-2003
Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids
Perretti M, Paul-Clark MJ, Mancini L, Flower RJ
Digestive and Liver Disease, Elsevier Bv vol. 35, S41-S48.  
01-05-2003
Exogenous annexin 1 promotes human neutrophil apoptosis
Solito E, Perretti M
 
01-04-2003
Annexin 1: An endogenous anti-inflammatory protein
Perretti M, Gavins FNE
News Physiol Sci vol. 18, 60-64.  
01-04-2003
Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory Actions of Melanocortin Peptides: Studies in the Recessive Yellow (e/e) Mouse Suggest an Important Role for Melanocortin 3 Receptor
Getting SJ, Christian HC, Lam CW, Gavins FNE, Flower RJ, Schiöth HB, Perretti M
The Journal of Immunology, Oxford University Press (Oup) vol. 170 (6), 3323-3330.  
15-03-2003
Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight
Parente L, Perretti M
Biochem Pharmacol vol. 65 (2), 153-159.  
15-01-2003
Glucocorticoid modulation of RANKL and osteoprotegerin in osteoblast cell lines
Mancini L, Paul-Clark MJ, Hannon R, MacIntyre I, Perretti M
 
01-01-2003
Effects of a novel NO-releasing glucocorticoid (NCX-1015) in a rat model of gout
Paul-Clark MJ, Getting SJ, Roviezzo F, Del Soldato P, Flower RJ, Perretti M
 
01-01-2003
Annexin 1 interactions with receptors of the formylated peptide family
Kamal AM, Giner RM, Paramasivam AM, Perretti M
 
01-01-2003
A novel calcium-dependent pro-apoptotic effect of annexin 1 on human neutrophils.
PERRETTI M, Marullo S, Buckingham JC, Russo-Marie F, Solito E, Kamal A
 
01-01-2003
A Boc-sensitive receptor, distinct from FPR, mediates the anti-inflammatory action of an annexin 1 peptide in the mouse heart
Gavins FNE, Flower RJ, Perretti M
 
01-01-2003
Neutrophil elastase (NE) plays a non-redundant role in zymosan-induced leukocyte migration
Young RE, Thompson RD, Larbi KY, La M, Roberts C, Shapir SD, Perretti M, Nourshargh S
 
01-01-2003
Characterisation of a novel glucocorticoid receptor inhuman platelets
Goulding NJ, Rickford AKB, Sherratt KM, Paul-Clark MJ, Flower RJ, Perretti M
 
01-01-2003
Anti-leukocyte properties of a novel non NO-based soluble guanylate cyclase activator, BAY 41-2272
Foster P, Mathur A, McLean P, Perretti M, Moncada S, Ahluwalia A, Hobbs A
 
01-01-2003
Melanocortin agonists possess anti-inflammatory effects in mice with a non-functional MC1-R (recessive yellow e/e)
Getting SJ, Lam CW, Christian HC, Gavins FNE, Flower RJ, Schiöth HB, Perretti M
 
01-01-2003
Evidence for specific Galectin-1 binding proteins on human neutrophil
La M, Chilton K, Hirabayashi J, Kasai K, Chernajovsky Y, Perretti M
 
01-01-2003
Anti-arthritic properties of an NO-donating glucocorticoid, NCX-1015
Paul-Clark MJ, Getting SJ, Flower RJ, Del Soldato P, Perretti M
 
01-01-2003
Melanocortin agonists possess anti-inflammatory effect in mice with a non-funetional MC1-R (recessive yellow e/e mice)
Getting SJ, Lam CW, Christian HC, Flower RJ, Schioth H, Perretti M
 
01-01-2003
Mast cell heterogeneity: analysis of annexin 1 expression in rat trachea
Oliani SM, Damazo AS, Paul-Clark MJ, Perretti M
 
01-01-2003
Migration of Specific Leukocyte Subsets in Response to Cytokine or Chemokine Application In Vivo
Perretti M, Getting SJ
In Inflammation Protocols, Springer Nature 139-146.  
01-01-2003
Regulation of kinin B1 receptors in emlothelial cells by laminar shear stress
Vo PA, Syed I, McLean P, Bascands JL, Perretti M, Ahluwalia A
 
01-01-2003
An annexin 1 peptide reduces myocardial ischaemia reperfusion in the mouse
Gavins FNE, Gao JL, Murphy PM, Flower RJ, Perretti M
 
01-01-2003
Protective role of melanocortin type 3 receptor in myocardial ischaemia-reperfusion injury in mice
Getting SJ, Di Filippo C, Lam CW, Rossi F, Flower RJ, D'Amico M, Perretti M
 
01-01-2003

2002

The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha-inhibitor-independent manner
Getting SJ, Mahoney DJ, Cao T, Rugg MS, Fries E, Milner CM, Perretti M, Day AJ
J Biol Chem vol. 277 (52), 51068-51076.  
27-12-2002
The annexin-1 knockout mouse: What it tells us about the inflammatory response
Roviezzo F, Getting SJ, Paul-Clark MJ, Yona S, Gavins FNE, Perretti M, Hannon R, Croxtall JD et al.
 
01-12-2002
Aberrant inflammation and resistance to glucocorticoids in Annexin 1(-/-) Mouse
Hannon R, Croxtall JD, Getting SJ, Roviezzo F, Yona S, Paul-Clark MJ, Gavins FNE, Perretti M et al.
Faseb J vol. 16 (14), 253-+.  
01-12-2002
NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice
Fiorucci S, Antonelli E, Distrutti E, Del Soldato P, Flower RJ, Clark MJP, Morelli A, Perretti M et al.
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 99 (24), 15770-15775.  
11-11-2002
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor.
Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CN
Nat Med vol. 8 (11), 1296-1302.  
01-11-2002
Annexin 1 localisation in tissue eosinophils as detected by electron microscopy
Oliani SM, Damazo AS, Perretti M
Mediat Inflamm vol. 11 (5), 287-292.  
01-10-2002
Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis
Getting SJ, Christian HC, Flower RJ, Perretti M
Arthritis Rheum vol. 46 (10), 2765-2775.  
01-10-2002
Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model.
Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E, Pitzalis C
J Immunol vol. 169 (4), 2085-2092.  
15-08-2002
Time-dependent expression of annexin 1 in a model of chronic granulomatous inflammation
Gibbs L, Carollo MG, Damazo AS, Oliani SM, Perretti M
Inflammation Research, Springer Science and Business Media Llc vol. 51 (6), 300-306.  
01-06-2002
Stromal Cell-Derived Factor 1 (CXCL12) Induces Human Cell Migration into Human Lymph Nodes Transplanted into SCID Mice
Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 168 (9), 4308-4317.  
01-05-2002
Chemokines as novel therapeutic targets in inflammatory diseases
Ajuebor MN, Swain MG, Perretti M
Biochemical Pharmacology, Elsevier Bv vol. 63 (7), 1191-1196.  
01-04-2002
Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery
Calatayud S, Mitchell JA, Perretti M, Giuliano F, Warner TD
European Journal of Pharmacology, Elsevier Bv vol. 440 (1), 71-77.  
01-04-2002
Annexin 1 interacts with L-selectin following neutrophil adhesion to endothelial cells
Perretti M, La M, Solito E
 
22-03-2002
Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo
Perretti M, Blades MC, Wheller SK, Wahid S, Solito E, Pitzalis C
 
20-03-2002
A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones
Malcangio M, Getting S, Grist J, Cunningham JR, Bradbury EJ, Issa PC, Lever IJ, Pezet S et al.
The Faseb Journal, Wiley vol. 16 (7), 730-732.  
12-03-2002
Stromal cell–derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID Mice
Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M, Pitzalis C
Arthritis &Amp; Rheumatism, Wiley vol. 46 (3), 824-836.  
01-03-2002
Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma
Carollo M, Getting SJ, Delaney S, Christie MI, Perretti M
 
01-02-2002
Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis
Paul-Clark MJ, Mancini L, Del Soldato P, Flower RJ, Perretti M
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 99 (3), 1677-1682.  
22-01-2002
A molecular mechanism for the clinical efficacy of ACTH in controlling human gout: activation of melanocortin type 3 receptor
Getting SJ, Flower RJ, Perretti M
 
01-01-2002
Altered degree of activation and steroid inhibition in leukocytes from annexin 1 null mice
Yona S, Perretti M, Buckingham JC, Morris JF, Flower RJ
 
01-01-2002
Functional evidence that somatostatin release contributes to GDNF anti-hyperalgesic and anti-inflammatory properties
Perretti M, GETTING SJ, Cunningham JR, Bradbury EJ, Malcangio M, Pezet S, Grist J, Lever IJ
 
01-01-2002
Annexin I -/- mice are resistant to the anti-inflammatory effect of glucocorticoids.
Yang YH, Getting SJ, Paul-Clark M, Liu DL, Perretti M, Flower RJ, Morand EF
 
01-01-2002
A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones.
Malcangio M, Getting SJ, Grist J, Cunningham JR, Bradbury EJ, Charbel Issa P, Lever IJ, Pezet S et al.
Faseb Journal Official Publication of The Federation of American Societies For Experimental Biology vol. 16 (7), 730-732.  
01-01-2002
Regulation of leukocyte-endothelial interactions by glucocorticoids
Pitzalis C, Pipitone N, Perretti M
 
01-01-2002
Galectin-1 inhibits neutrophil chemotaxis in vitro and migration in vivo: Indication for a novel endogenous anti-inflammatory loop
La M, Cao T, Hirabayashi J, Kasai K, Chernajovsky Y, Perretti M
 
01-01-2002
Link tumor necrosis factor stimulatory gene-6 (LINK_TSG6) has neutrophil anti-migratory effects in-vivo
Cao T, Day AJ, Perretti M
 
01-01-2002
Annexin 1 peptide protects against ischaemia reperfusion in the mouse mesentery
Gavins FNE, Gao J, Murphy PM, Flower RJ, Perretti M
 
01-01-2002
The annexin-1 knockout mouse: What it tells us about the inflammatory response.
Roviezzo F, Getting SJ, Paul-Clark MJ, Yona S, Gavins FNE, Perretti M, Hannon R, Croxtall JD et al.
 
01-01-2002
Annexin 1 peptide inhibits ischaemia reperfusion (IR)-induced leukocyte adhesion and emigration: Receptors involved
Gavins FNE, Gao JL, Murphy PM, Tailor A, Granger DN, Flower RJ, Perretti M
 
01-01-2002
Activation of melanocortin type 3 receptor as a novel mechanism for ACTH efficacy in gouty arthritis
Getting SJ, Flower RJ, Perretti M
 
01-01-2002
Stromal cell derived factor-1 (CXCL 12) induces monocyte migration into human synovium transplanted onto SCID mice.
PERRETTI M, Manzo A, Wheller SK, Ingegnoli F, Blades MC, Petzalis C, Wahid S, Panayi GS
Arth Rheum vol. 46, 824-836.  
01-01-2002
Effect of galectin-1 on neutrophil chemotaxis in vitro and migration in vivo
La M, Cao T, Chernajovsky Y, Perretti M
 
01-01-2002

2001

Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1
Allcock GH, Allegra M, Flower RJ, Perretti M
Clinical and Experimental Immunology, Oxford University Press (Oup) vol. 123 (1), 62-67.  
20-12-2001
Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1 alpha and MCP-1
Carollo M, Hogaboam CM, Kunkel SL, Delaney S, Christie MI, Perretti M
Brit J Pharmacol vol. 134 (6), 1166-1179.  
01-11-2001
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virág L, Szabó É, Soriano FG et al.
Inflammation Research, Springer Science and Business Media Llc vol. 50 (11), 561-569.  
01-11-2001
Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment
La M, Tailor A, D'Amico M, Flower RJ, Perretti M
European Journal of Pharmacology vol. 429 (1-3), 263-278.  
19-10-2001
Annexin 1 peptides protect against experimental myocardial ischemia‐reperfusion: analysis of their mechanism of action
La M, D'Amico M, Bandiera S, Filippo CD, Oliani SM, Gavins FNE, Flower RJ, Perretti M
 
01-10-2001
Cytokine modulation of liver annexin 1 expression during experimental endotoxemia
de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M, Solito E
Am J Pathol vol. 159 (4), 1435-1443.  
01-10-2001
Arthritic diseases: Melanocortin type 3 receptor agonists as potential therapeutics
Getting SJ, Perretti M
Current Opinion in Investigational Drugs vol. 2 (8), 1064-1069.  
04-09-2001
MORPHOLOGICAL ALTERATION OF PERITONEAL MAST CELLS AND MACROPHAGES IN THE MOUSE PERITONEAL CAVITY DURING THE EARLY PHASES OF AN ALLERGIC INFLAMMATORY REACTION
Oliani SM, Lim LHK, Christian HC, Pell K, Das AM, Perretti M
Cell Biology International, Wiley vol. 25 (8), 795-803.  
01-08-2001
Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity
Damazo AS, Tavares de Lima W, Perretti M, Oliani SM
European Journal of Pharmacology, Elsevier Bv vol. 426 (1-2), 123-130.  
01-08-2001
The Use of Lymphocyte Function–Associated Antigen (Lfa)-1–Deficient Mice to Determine the Role of Lfa-1, Mac-1, and α4 Integrin in the Inflammatory Response of Neutrophils
Henderson RB, Lim LHK, Tessier PA, Gavins FNE, Mathies M, Perretti M, Hogg N
The Journal of Experimental Medicine, Rockefeller University Press vol. 194 (2), 219-226.  
16-07-2001
Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics
Perretti M, Getting SJ, Solito E, Murphy PM, Gao JL
Am J Pathol vol. 158 (6), 1969-1973.  
01-06-2001
Enhanced serum glucocorticoid levels mediate the reduction of serosal mast cell numbers in diabetic rats
Diaz B, Barreto E, Cordeiro R, Perretti M, Martins M, Silva P
Life Sciences, Elsevier Bv vol. 68 (26), 2925-2932.  
01-05-2001
Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation
Solito E, de Coupade C, Canaider S, Goulding NJ, Perretti M
Brit J Pharmacol vol. 133 (2), 217-228.  
01-05-2001
Mechanism of reaction of melatonin with human myeloperoxidase
Allegra M, Furtmuller PG, Regelsberger G, Turco-Liveri ML, Tesoriere L, Perretti M, Livrea RA, Obinger C
Biochem Bioph Res Co vol. 282 (2), 380-386.  
30-03-2001
Neutrophil Interaction with Inflamed Postcapillary Venule Endothelium Alters Annexin 1 Expression
Oliani SM, Paul-Clark MJ, Christian HC, Flower RJ, Perretti M
The American Journal of Pathology, Elsevier Bv vol. 158 (2), 603-615.  
01-02-2001
Comparison of the effects of the selective COX-2 inhibitor, DFP, and indomethacin on leukocyte-endothelial cell interactions in the rat mesentery
Calatayud S, Allcock GH, Perretti M, Mitchell JA, Warner TD
 
01-01-2001
Development of a new model to investigate lymphocyte migration into human peripheral lymph nodes (HPLN) transplanted into SCID mice
Blades MC, Ingegnoli F, Manzo A, Wahid S, Haskard D, Panayi G, Perretti M, Pitzalis C
Rheumatology vol. 40, 66-66.  
01-01-2001
Cell localization of the anti-inflammatory protein annexin 1 during experimental inflammatory response
Oliani SM, Perretti M
 
01-01-2001
Annexin-1-derived peptides protect against myocardial ischaemia reperfusion injury
La M, Bandiera S, Flower RJ, Perretti M
 
01-01-2001
Effect of melanocortin agonists on joint inflammation
Getting SJ, Flower RJ, Perretti M
 
01-01-2001
Interaction with the formylated receptor (FPR) is at the basis of annexin 1 anti-inflammatory effects
Perretti M, Wheller SK, Getting SJ, Gao JL
 
01-01-2001
Glucocorticoids modulate osteoprotegerin/osteoprotegerin ligand and osteoclast activity
Mancini L, MacIntyre I, Perretti M
 
01-01-2001
Involvement of FPR in the anti-inflammatory action of annexin-1
Perretti M, Wheller SK, Getting SJ, Gao JL
 
01-01-2001
Monocyte CD163 expression is regulated by glucocorticoids and lipopolysaccharide but not by chemokines
Goulding NJ, Rajakulendran S, Goulding PN, Perretti M, Flower RJ, Guyre PM
 
01-01-2001
Glucocorticoids and leukocyte adhesion
Pitzalis C, Pipitone N, Perretti M
In Glucocorticoids, BirkhäUser Basel 105-118.  
01-01-2001
Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties
Getting SJ, Allcock GH, Flower R, Perretti M
J Leukocyte Biol vol. 69 (1), 98-104.  
01-01-2001
Effect of a novel poly (ADP-ribose) polymerase (PARP) inhibitor in rodent models of local inflammation
Mabley J, Virag L, Jagtap P, Szabo E, Prendergast R, Perretti M, Getting S, Szabo C
 
01-01-2001

2000

21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties
Paul-Clark M, Del Soldato P, Fiorucci S, Flower RJ, Perretti M
Brit J Pharmacol vol. 131 (7), 1345-1354.  
01-12-2000
Modulation of the Effects of Osteoprotegerin (OPG) Ligand in a Human Leukemic Cell Line by OPG and Calcitonin
Mancini L, Moradi-Bidhendi N, Brandi ML, Perretti M, MacIntyre I
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 279 (2), 391-397.  
01-12-2000
Kinin B1 receptors and the cardiovascular system: regulation of expression and function
McLean P
Cardiovascular Research, Oxford University Press (Oup) vol. 48 (2), 194-210.  
01-11-2000
Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment.
D'Amico M, Di Filippo C, La M, Solito E, McLean PG, Flower RJ, Oliani SM, Perretti M
Faseb J vol. 14 (13), 1867-1869.  
01-10-2000
An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: Modulation by inflammation and dexamethasone
Oliani SM, Christian HC, Manston J, Flower RJ, Perretti M
Lab Invest vol. 80 (9), 1429-1438.  
01-09-2000
Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules
McLean PG, Ahluwalia A, Perretti M
The Journal of Experimental Medicine, Rockefeller University Press vol. 192 (3), 367-380.  
31-07-2000
Heparin and inflammation: a new use for an old GAG?
PERRETTI M
Gut, Bmj vol. 47 (1), 14-15.  
01-07-2000
Glucocorticoid receptor activation reduces CD11b and CD49d levels on murine eosinophils - Characterization and functional relevance
Lim LHK, Flower RJ, Perretti M, Das AM
Am J Resp Cell Mol vol. 22 (6), 693-701.  
01-06-2000
The Microcirculation and Inflammation: Site of Action for Glucocorticoids
PERRETTI M, AHLUWALIA A
Microcirculation, Wiley vol. 7 (3), 147-161.  
01-06-2000
MC3-R as a novel target for antiinflammatory therapy
Getting SJ, Perretti M
Drug News and Perspectives vol. 13 (1), 19-27.  
25-05-2000
Kinin B1receptors as novel anti-inflammatory targets
McLean PG, Perretti M, Ahluwalia A
Emerging Therapeutic Targets, Informa Uk Limited vol. 4 (2), 127-141.  
01-04-2000
Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I).
Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ, Perretti M
Life Sci vol. 66 (18), PL265-PL270.  
24-03-2000
Analysis of osteoprotegerin ligand effects on the FLG 29.1 pre-osteoclastic cell line
Mancini L, MacIntyre L, Brandi ML, Perretti M
 
01-01-2000
Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis
Perretti M, Christian H, Wheller SK, Aiello I, Mugridge KG, Morris JF, Flower RJ, Goulding NJ
Cell Biol Int vol. 24 (3), 163-174.  
01-01-2000
Expression of MIP-2, KC and MCR-1 and their receptors in chronic granulomatous inflammation
Carollo M, Christie MI, Perretti M
 
01-01-2000

1999

Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx
Getting SJ, Flower RJ, Perretti M
 
01-12-1999
Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC
Tailor A, Tomlinson A, Salas A, Panes J, Granger DN, Flower RJ, Perretti M
Gut vol. 45 (5), 705-712.  
01-11-1999
Inducible expression of the kinin B1 receptor in the endotoxemic heart: mechanisms of des‐Arg9bradykinin‐induced coronary vasodilation
McLean PG, Perretti M, Ahluwalia A
British Journal of Pharmacology, Wiley vol. 128 (2), 275-282.  
01-09-1999
Contrasting roles for RANTES and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in a murine model of allergic peritonitis
Das AM, Ajuebor MN, Flower RJ, Perretti M, McColl SR
Clin Exp Immunol vol. 117 (2), 223-229.  
01-08-1999
POMC gene-derived peptides activate melanocortin type 3 receptor or murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation
Getting SJ, Gibbs L, Clark AJL, Flower RJ, Perretti M
J Immunol vol. 162 (12), 7446-7453.  
15-06-1999
Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions
Perretti M, Wheller SK, Flower RJ, Wahid S, Pitzalis C
J Leukocyte Biol vol. 65 (5), 583-589.  
01-05-1999
B1 receptors as a new inflammatory target. Could this B the 1?
Ahluwalia A, Perretti M
Trends in Pharmacological Sciences, Elsevier Bv vol. 20 (3), 100-104.  
01-03-1999
Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1
Minghetti L, Nicolini A, Polazzi E, Greco A, Perretti M, Parente L, Levi G
Brit J Pharmacol vol. 126 (6), 1307-1314.  
01-03-1999
Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: Evidence for an inhibitory loop involving endogenous IL-10
Ajuebor MN, Das AM, Virag L, Flower RJ, Szabo C, Perretti M
J Immunol vol. 162 (3), 1685-1691.  
01-02-1999
Regulation of Macrophage Inflammatory Protein-1α Expression and Function by Endogenous Interleukin-10 in a Model of Acute Inflammation
Ajuebor MN, Das AM, Virág L, Szabó C, Perretti M
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 255 (2), 279-282.  
01-02-1999
Differential modulation of annexin I binding sites on monocytes and neutrophils
Euzger HS, Flower RJ, Goulding NJ, Perretti M
Mediat Inflamm vol. 8 (1), 53-62.  
01-01-1999
Upregulation of ICAM‐1 Expression on J774.2 Macrophages by Endotoxin Involves Activation of NF‐κB but not Protein Tyrosine Kinase: Comparison to Induction of iNOS
Ruetten H, Thiemermann C, Perretti M
Mediators of Inflammation, Wiley vol. 8 (2), 77-84.  
01-01-1999
Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx
Getting SJ, Flower RJ, Perretti M
 
01-01-1999

1998

Novel pathways for glucocorticoid effects on neutrophils in chronic inflammation
Goulding NJ, Euzger HS, Butt SK, Perretti M
 
04-12-1998
Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan‐induced inflammation
AJUEBOR, VIRÁG, FLOWER, PERRETTI, SZABÓ
Immunology, Wiley vol. 95 (4), 625-630.  
01-12-1998
Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1.
Lim LH, Solito E, Russo-Marie F, Flower RJ, Perretti M
Proc Natl Acad Sci U S A vol. 95 (24), 14535-14539.  
24-11-1998
Lipocortin 1 and Chemokine Modulation of Granulocyte and Monocyte Accumulation in Experimental Inflammation
Perretti M
General Pharmacology: The Vascular System, Elsevier Bv vol. 31 (4), 545-552.  
01-10-1998
Investigation of the functional role played by the chemokine monocyte chemoattractant protein‐1 in interleukin‐1‐induced murine peritonitis
Ajuebor MN, Gibbs L, Flower RJ, Das AM, Perretti M
British Journal of Pharmacology, Wiley vol. 125 (2), 319-326.  
01-09-1998
Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo
Das AM, Flower RJ, Perretti M
J Leukocyte Biol vol. 64 (2), 156-162.  
01-08-1998
Impaired IL‐1β‐induced neutrophil accumulation in tachykinin NK1 receptor knockout mice
Ahluwalia A, De Felipe C, O'Brien J, Hunt SP, Perretti M
British Journal of Pharmacology, Wiley vol. 124 (6), 1013-1015.  
01-07-1998
The relative contribution of constitutive and inducible cyclooxygenase activity to lipopolysaccharide-induced prostaglandin production by primary cultures of rat hypothalamic astrocytes
Pistritto G, Mancuso C, Tringali G, Perretti M, Preziosi P, Navarra P
Neuroscience Letters, Elsevier Bv vol. 246 (1), 45-48.  
01-04-1998
Suppression by dexamethasone of inducible nitric oxide synthase protein expression in vivo - A possible role for lipocortin 1
Bryant CE, Perretti M, Flower RJ
Biochem Pharmacol vol. 55 (3), 279-285.  
01-02-1998
The role of lipocortin‐1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse
Teixeira MM, Das AM, Miotla JM, Perretti M, Hellewell PG
British Journal of Pharmacology, Wiley vol. 123 (3), 538-544.  
01-02-1998
Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model
Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A, Perretti M
J Leukocyte Biol vol. 63 (1), 108-116.  
01-01-1998

1997

Dexamethasone reduces cell surface levels of CD11b on human eosinophils
Das AM, Lim LHK, Flower RJ, Perretti M
Mediat Inflamm vol. 6 (5-6), 363-367.  
01-12-1997
Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration
Cuzzocrea S, Tailor A, Zingarelli B, Salzman AL, Flower RJ, Szabo C, Perretti M
J Immunol vol. 159 (10), 5089-5097.  
15-11-1997
Endogenous mediators that inhibit the leukocyte– endothelium interaction
Perretti M
Trends in Pharmacological Sciences, Elsevier Bv vol. 18 (11), 418-425.  
01-11-1997
Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects
Szabo C, Lim LHK, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, Salzman AL, Perretti M
J Exp Med vol. 186 (7), 1041-1049.  
06-10-1997
Molecular determinants of monosodium urate crystal-induced murine peritonitis: A role for endogenous mast cells and a distinct requirement for endothelial-derived selectins
Getting SJ, Flower RJ, Parente L, DeMedicis R, Lussier A, Woliztky BA, Martins MA, Perretti M
J Pharmacol Exp Ther vol. 283 (1), 123-130.  
01-10-1997
Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: An intravital microscopy study
Tailor A, Flower RJ, Perretti M
J Leukocyte Biol vol. 62 (3), 301-308.  
01-09-1997
Eotaxin-induced eosinophil migration in the peritoneal cavity of ovalbumin-sensitized mice - Mechanism of action
Das AM, Flower RJ, Perretti M
J Immunol vol. 159 (3), 1466-1473.  
01-08-1997
Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone
Ferreira SH, Cunha FQ, Lorenzetti BB, Michelin MA, Perretti M, Flower RJ, Poole S
Brit J Pharmacol vol. 121 (5), 883-888.  
01-07-1997
Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines
Wheller SK, Perretti M
European Journal of Pharmacology, Elsevier Bv vol. 331 (1), 65-71.  
01-07-1997
A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment
Das AM, Flower RJ, Hellewell PG, Teixeira MM, Perretti M
Brit J Pharmacol vol. 121 (1), 97-104.  
01-05-1997
Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1
Getting SJ, Flower RJ, Perretti M
Brit J Pharmacol vol. 120 (6), 1075-1082.  
01-03-1997
Subacute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes
Tailor A, Das AM, Getting SJ, Flower RJ, Perretti M
Biochem Bioph Res Co vol. 231 (3), 675-678.  
24-02-1997

1996

Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration
Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon R, Flower RJ
Nat Med vol. 2 (11), 1259-1262.  
01-11-1996
Relative Contribution of the Selectins in the Neutrophil Recruitment Caused by the Chemokine Cytokine-Induced Neutrophil Chemoattractant (CINC)
Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA, Perretti M
Biochemical and Biophysical Research Communications, Elsevier Bv vol. 224 (3), 878-879.  
01-07-1996
Modulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-1 beta and dexamethasone
Perretti M, Wheller SK, Harris JG, Flower RJ
Biochem Bioph Res Co vol. 223 (1), 112-117.  
05-06-1996
Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: Modulation by glucocorticoids and inflammation
Perretti M, Flower RJ
Brit J Pharmacol vol. 118 (3), 605-610.  
01-06-1996
Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC)
Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA, Perretti M
Biochem Bioph Res Co vol. 221 (3), 692-696.  
25-04-1996
Effect of interleukin-1 beta on the release of substance P from rat isolated spinal cord
Malcangio M, Bowery NG, Flower RJ, Perretti M
Eur J Pharmacol vol. 299 (1-3), 113-118.  
28-03-1996
Acute inflammatory response in the mouse: Exacerbation by immunoneutralization of lipocortin 1
Perretti M, Ahluwalia A, Harris JG, Harris HJ, Wheller SK, Flower RJ
Brit J Pharmacol vol. 117 (6), 1145-1154.  
01-03-1996
Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse.
Ahluwalia A, Perretti M
The Journal of Immunology, Oxford University Press (Oup) vol. 156 (1), 269-274.  
01-01-1996

1995

Gastric antisecretory and anti-ulcer actions of IL-1 in rat involve different IL-1 receptor types
Mugridge KG, Perretti M, Ghiara P, Galeotti CL, Melli M, Parente L
American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society vol. 269 (5), G763-G769.  
01-11-1995
Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse
Perretti M, Szabó C, Thiemermann C
British Journal of Pharmacology, Wiley vol. 116 (4), 2251-2257.  
01-10-1995
SELECTIVE-INHIBITION OF NEUTROPHIL FUNCTION BY A PEPTIDE DERIVED FROM LIPOCORTIN-1 N-TERMINUS
PERRETTI M, WHELLER SK, CHOUDHURY Q, CROXTALL JD, FLOWER RJ
Biochem Pharmacol vol. 50 (7), 1037-1042.  
28-09-1995
ENDOGENOUS CORTICOSTEROIDS MEDIATE THE NEUTROPHILIA CAUSED BY PLATELET-ACTIVATING-FACTOR IN THE MOUSE
HARRIS JG, FLOWER RJ, PERRETTI M
Eur J Pharmacol vol. 283 (1-3), 9-18.  
05-09-1995
LEUKOCYTE TRANSMIGRATION, BUT NOT ROLLING OR ADHESION, IS SELECTIVELY INHIBITED BY DEXAMETHASONE IN THE HAMSTER POST-CAPILLARY VENULE - INVOLVEMENT OF ENDOGENOUS LIPOCORTIN-1
MANCUSO F, FLOWER RJ, PERRETTI M
J Immunol vol. 155 (1), 377-386.  
01-07-1995
Effect of rolipram in a murine model of acute inflammation: comparison with the corticoid dexamethasone
Klemm P, Harris HJ, Perretti M
European Journal of Pharmacology, Elsevier Bv vol. 281 (1), 69-74.  
01-07-1995
Inhibition of interleukin-1β-induced pyresis in the rabbit by peptide 204–212 of lipocortin 5
Palmi M, Frosini M, Sgaragli GP, Becherucci C, Perretti M, Parente L
European Journal of Pharmacology, Elsevier Bv vol. 281 (1), 97-99.  
01-07-1995
ALTERATION OF NEUTROPHIL TRAFFICKING BY A LIPOCORTIN-1 N-TERMINUS PEPTIDE
HARRIS JG, FLOWER RJ, PERRETTI M
Eur J Pharmacol vol. 279 (2-3), 149-157.  
12-06-1995
LIPOCORTIN-1 MEDIATES THE INHIBITION BY DEXAMETHASONE OF THE INDUCTION BY ENDOTOXIN OF NITRIC-OXIDE SYNTHASE IN THE RAT
WU CC, CROXTALL JD, PERRETTI M, BRYANT CE, THIEMERMANN C, FLOWER RJ, VANE JR
P Natl Acad Sci Usa vol. 92 (8), 3473-3477.  
11-04-1995
Anti-inflammatory lipocortin-derived peptides
PERRETTI M, FLOWER RJ
 
01-01-1995
Anti-Inflammatory Lipocortin-Derived Peptides
Perretti M, Flower RJ
In Novel Molecular Approaches to Anti-Inflammatory Therapy 131-138.  
01-01-1995

1994

Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse
Ahluwalia A, Perretti M
European Journal of Pharmacology, Elsevier Bv vol. 264 (3), 407-415.  
01-11-1994
CYTOKINES, GLUCOCORTICOIDS AND LIPOCORTINS IN THE CONTROL OF NEUTROPHIL MIGRATION
PERRETTI M, FLOWER RJ
Pharmacol Res vol. 30 (1), 53-59.  
01-07-1994
A ROLE FOR ENDOGENOUS HISTAMINE IN INTERLEUKIN-8-INDUCED NEUTROPHIL INFILTRATION INTO MOUSE AIR-POUCH - INVESTIGATION OF THE MODULATORY ACTION OF SYSTEMIC AND LOCAL DEXAMETHASONE
PERRETTI M, HARRIS JG, FLOWER RJ
Brit J Pharmacol vol. 112 (3), 801-808.  
01-07-1994
Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors.
Ahluwalia A, Perretti M
The Journal of Pharmacology and Experimental Therapeutics, Elsevier Bv vol. 268 (3), 1526-1531.  
01-03-1994
Lipocortin-derived peptides
Perretti M
Biochemical Pharmacology, Elsevier Bv vol. 47 (6), 931-938.  
01-03-1994
Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo.
Szabó C, Thiemermann C, Wu CC, Perretti M, Vane JR
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 91 (1), 271-275.  
04-01-1994

1993

LIPOCORTIN-1 FRAGMENTS INHIBIT NEUTROPHIL ACCUMULATION AND NEUTROPHIL-DEPENDENT EDEMA IN THE MOUSE - A QUALITATIVE COMPARISON WITH AN ANTI-CD11B MONOCLONAL-ANTIBODY
PERRETTI M, AHLUWALIA A, HARRIS JG, GOULDING NJ, FLOWER RJ
J Immunol vol. 151 (8), 4306-4314.  
15-10-1993
SERUM CORTICOSTERONE, INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR IN RAT EXPERIMENTAL ENDOTOXEMIA - COMPARISON BETWEEN LEWIS AND WISTAR STRAINS
PERRETTI M, DUNCAN GS, FLOWER RJ, PEERS SH
Brit J Pharmacol vol. 110 (2), 868-874.  
01-10-1993
ENDOGENOUS TACHYKININS PLAY A ROLE IN IL-1-INDUCED NEUTROPHIL ACCUMULATION - INVOLVEMENT OF NK-1 RECEPTORS
PERRETTI M, AHLUWALIA A, FLOWER RJ, MANZINI S
Immunology vol. 80 (1), 73-77.  
01-09-1993
Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock
Thiemermann C, Wu C, Szabó C, Perretti M, Vane JR
British Journal of Pharmacology, Wiley vol. 110 (1), 177-182.  
01-09-1993
THE ABILITY OF MURINE LEUKOCYTES TO BIND LIPOCORTIN-1 IS LOST DURING ACUTE-INFLAMMATION
PERRETTI M, FLOWER RJ, GOULDING NJ
Biochem Bioph Res Co vol. 192 (2), 345-350.  
30-04-1993
ANTIINFLAMMATORY ACTIONS OF AN N-TERMINAL PEPTIDE FROM HUMAN LIPOCORTIN-1
CIRINO G, CICALA C, SORRENTINO L, CILIBERTO G, ARPAIA G, PERRETTI M, FLOWER RJ
Brit J Pharmacol vol. 108 (3), 573-574.  
01-03-1993
Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1
Da Silva JAP, Peers SH, Perretti M, Willoughby DA
Journal of Endocrinology, Bioscientifica vol. 136 (3), 389-397.  
01-03-1993
MODULATION OF IL-1-INDUCED NEUTROPHIL MIGRATION BY DEXAMETHASONE AND LIPOCORTIN-1
PERRETTI M, FLOWER RJ
J Immunol vol. 150 (3), 992-999.  
01-02-1993
PHARMACOLOGY OF INTERLEUKIN-1-INDUCED NEUTROPHIL MIGRATION
PERRETTI M, APPLETON I, PARENTE L, FLOWER RJ
 
01-01-1993
Inhibition of smooth muscle contraction and platelet aggregation by peptide 204–212 of lipocortin 5: an attempt to define some structure requirements
Mugridge KG, Becherucci C, Parente L, Perretti M
Mediators of Inflammation, Wiley vol. 2 (2), 103-107.  
01-01-1993
Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5.
Becherucci C, Perretti M, Solito E, Galeotti CL, Parente L
Mediators Inflamm vol. 2 (2), 109-113.  
01-01-1993

1992

The role of lipocortin 1 in the regulation of A549 cell proliferation and leukocyte migration
Croxtall J, Flower R, Perretti M
 
01-12-1992
PEPTIDE-204-212 OF LIPOCORTIN-5 INHIBITS THE GENERATION OF A PROSTACYCLIN-LIKE FACTOR FROM RAT AORTA PREPARATIONS INVITRO
DOUGLAS GJ, FLOWER RJ, PARENTE L, PERRETTI M
Prostaglandins vol. 44 (5), 381-388.  
01-11-1992
Mechanism of the protective action of interleukin-1 in the experimental gastric damage in the rat
Parente L, Perretti M, Wallace JL, Mugridge KG
Pharmacological Research, Elsevier Bv vol. 26, 28-29.  
01-09-1992
Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids.
Perretti M, Mugridge KG, Wallace JL, Parente L
The Journal of Pharmacology and Experimental Therapeutics, Elsevier Bv vol. 261 (3), 1238-1247.  
01-06-1992
Anti-inflammatory effect of tuftsin and its retro-inverso analogue in rat adjuvant arthritis
Becherucci C, Perretti M, Nencioni L, Silvestri S, Parente L
Agents and Actions, Springer Science and Business Media Llc vol. 36 (S1), C115-C117.  
01-03-1992
Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice.
Perretti M, Solito E, Parente L
Agents Actions vol. 35 (1-2), 71-78.  
01-01-1992

1991

Immunostimulation by a partially modified retro-inverso-tuftsin analog containing Thr1.sum..psi.[NHCO](R,S)Lys2 modification
Verdini AS, Silvestri S, Becherucci C, Longobardi MG, Parente L, Peppoloni S, Perretti M, Pileri P et al.
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 34 (12), 3372-3379.  
01-12-1991
A novel anti-inflammatory peptide from human lipocortin 5.
Perretti M, Becherucci C, Mugridge KG, Solito E, Silvestri S, Parente L
Br J Pharmacol vol. 103 (2), 1327-1332.  
01-06-1991
α-melanocyte-stimulating hormone reduces interleukin-lβ effects on rat stomach preparations possibly through interference with a type I receptor
Mugridge KG, Perretti M, Ghiara P, Parente L
European Journal of Pharmacology, Elsevier Bv vol. 197 (2-3), 151-155.  
01-05-1991
5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and Related 4-Amino Compounds: Synthesis and Pharmacological Evaluation
Piaz VD, Ciciani G, Turco G, Giovannoni MP, Miceli M, Pirisino R, Perretti M
Journal of Pharmaceutical Sciences, Elsevier Bv vol. 80 (4), 341-348.  
01-04-1991
5-Lipoxygenase activation may facilitate an interleukin-1 transduction signal.
Mugridge KG, Perretti M, Parente L
Advances in Prostaglandin Thromboxane and Leukotriene Research vol. 21 B, 517-520.  
01-01-1991
Evidence that interleukin-1 and lipoxygenase metabolites mediate the lethal effect of complete Freund's adjuvant in adrenalectomized rats
Perretti M, Mugridge KG, Becherucci C, Parente L
Lymphokine and Cytokine Research vol. 10 (4), 239-243.  
01-01-1991

1990

Antiulcer property of human recombinant interleukin-1β
Perretti M, Mugridge KG, Becherucci C, Silvestri S, Parente L
Pharmacological Research, Elsevier Bv vol. 22, 392-392.  
01-09-1990
In vitro and in vivo activation of phospholipase A2 by interleukin-1
Parente L, Mugridge KG, Perretti M, Solito E
Pharmacological Research, Elsevier vol. 22 
01-09-1990
Different anti-inflammatory effects of lipocortins 1 and 5
Becherucci C, Perretti M, Galeotti C, Parente L
Pharmacological Research, Elsevier Bv vol. 22, 34-34.  
01-09-1990
Investigation of rat mast cell degranulation using flow cytometry
Perretti M, Nuti S, Parente L
Journal of Pharmacological Methods, Elsevier Bv vol. 23 (3), 187-194.  
01-05-1990
Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase.
Mugridge KG, Perretti M, Becherucci C, Parente L
The Journal of Pharmacology and Experimental Therapeutics, Elsevier Bv vol. 256 (1), 29-37.  
01-01-1990
Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids?
Parente L, Becherucci C, Perretti M, Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M et al.
Prog Clin Biol Res vol. 349, 55-68.  
01-01-1990
Purification and biological activity of human lipocortin 2.
Becherucci C, Solito E, Perretti M, Mugridge KG, Galeotti CL, Parente L
Pharmacol Res vol. 22 Suppl 1, 29-30.  
01-01-1990

1989

The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo
Perretti M, Becherucci C, Scapigliati G, Parente L
British Journal of Pharmacology, Wiley vol. 98 (4), 1137-1142.  
01-12-1989
The release of interleukin-1-like activity by macrophages in two models of immunological inflammation in the rat
Becherucci C, Donati D, Perretti M, Parente L
Agents and Actions, Springer Science and Business Media Llc vol. 28 (3-4), 243-247.  
01-11-1989

1988

Interleukin-1 release by macrophages from adrenalectomized (ADX) and shamoperated (SHO) rats
Perretti M, Becherucci C, Parente L
Pharmacological Research Communications, Elsevier Bv vol. 20, 299-299.  
01-09-1988
Interleukin-1 release by rat macrophages in experimental immunological inflammation
Becherucci C, Donati D, Perretti M, Parente L
Pharmacological Research Communications, Elsevier Bv vol. 20, 29-29.  
01-09-1988
Induction and quail liver diamine oxidase (histaminase). Part II: Different responses to the inducers
Ignesti G, Buffoni F, Perretti M, Cintelli A
Agents and Actions, Springer Science and Business Media Llc vol. 25 (1-2), 43-47.  
01-08-1988
Induction and quail liver diamine oxidase (histaminase). Part I: Interference of spermidine synthase on the diamine oxidase activity assay using putrescine as substrate
Ignesti G, Perretti M, Buffoni F
Agents and Actions, Springer Science and Business Media Llc vol. 25 (1-2), 37-42.  
01-08-1988

1986

Diamine oxidase activity in Japanese quail liver induced with Aroclor 1254
Ignesti G, Perretti M, Buffoni F
Agents and Actions, Springer Science and Business Media Llc vol. 18 (1-2), 41-43.  
01-04-1986

1981

Plasma amine oxidases in Wilson's disease
Bombardieri G, Bevilacqua E, Conti LR, Innocenti P, Perretti MA
Life Sciences, Elsevier Bv vol. 29 (2), 117-120.  
01-07-1981

Anti-inflammatory glucocorticoids and annexin 1
Perretti M, Flower RJ
In Progress in Inflammation Research, BirkhäUser Basel 141-158.  
Migration of Specific Leukocyte Subsets in Response to Cytokine or Chemokine Application In Vivo
Perretti M, Getting SJ
In Inflammation Protocols, Humana Press 139-146.  
Treatment
Perretti M, D'Acquisto F, Flower RJ
Patent WO2010064012. 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconCharacterizing the biology of GPR173 in neutrophils
Jesmond Dalli and Mauro Perretti
£74,998 Barts and the London Charity
01-09-2025 - 31-08-2026
bullet iconGRIFOLS - POC- Repurposing alpha-1-Antitrypsin as a treatment for Osteoarthritis (pilot investigation)
Magdalena K Kaneva and Mauro Perretti
£149,308 Grifols (Shared Services North America)
01-09-2025 - 31-08-2026
solid heart iconAnti-inflammatory and Pro-resolving profiles of south Africa medicinal plants
Mauro Perretti and Roberto Buccafusca
£282,802 Royal Society
07-10-2024 - 06-10-2026
solid heart iconAssessing the pro-resolving and anti-arthritic properties of cannabidiol in chronic inflammation
Mauro Perretti and Lucy Norling
£130,358 WHRL William Harvey Research Limited
01-10-2024 - 31-03-2026
solid heart iconExtracellular Vesicle Communication for Nociceptive Processing In Acute And Chronic Pain
Mauro Perretti
£783,380 MRC Medical Research Council
01-10-2024 - 30-09-2029
solid heart iconBlood analysis protocol: Efficacy of RTP026 in MI patients
Mauro Perretti, Jianmin Chen and Sharmilee Gnanapavan
£261,605 William Harvey Research Limited
01-09-2024 - 28-02-2027
bullet iconDrug development and pre-clinical evaluation of novel ACTH-based peptides
Trinidad Montero Melendez and Mauro Perretti
£493,277 Lorna & Yuti Chernajovsky Biomedical Research Foundation, The
01-08-2024 - 31-07-2027
solid heart iconRepurposing Alpha-1-antitrypsin as a treatment for post-traumatic osteoarthritis
Mauro Perretti and Magdalena K Kaneva
£566,515 MRC Medical Research Council
01-05-2024 - 30-04-2027
solid heart iconMelancortins to control cystic fibrosis airway inflammation
Mauro Perretti, Charles Mein and Lucy Norling
£21,271 Italian Cystic Fibrosis Research Foundation Fondazione Italiana per la ricerca sulla Fibrosi Cistica
01-12-2023 - 30-11-2025
bullet iconExploring the cholesterol transport pathway as a therapeutic target for Ebola infection
Trinidad Montero Melendez and Mauro Perretti
£294,436 Barts and the London Charity
01-02-2023 - 31-01-2026
solid heart iconrhu-pGelsolin for treatment of arthritis
Mauro Perretti, Magdalena K Kaneva and Shafaq Sikandar
£460,135 BioAegis Therapeutics
01-02-2023 - 30-09-2025
bullet iconHarmonised IAA grant - Improve and accelerate the impact of QMUL research MRC
Mauro Perretti, Tatjana Crnogorac-Jurcevic and David Lee
£457,000 MRC Medical Research Council
01-04-2022 - 31-03-2026
solid heart iconTesting novel peptides
Mauro Perretti
£45,706 WHRL William Harvey Research Limited
01-01-2022 - 31-12-2026
bullet iconAnalysis of novel melanocortin receptor peptide agonists - phase 2
Mauro Perretti and Trinidad Montero Melendez
£374,313 WHRL William Harvey Research Limited
01-04-2021 - 31-12-2025
bullet iconInvestigating the role of neutrophils in aspirin treatment for women at high risk of preeclampsia
Suchita Nadkarni and Mauro Perretti
£258,149 Barts and the London Charity
04-01-2021 - 31-12-2025
bullet iconLondon Covid19 Alliance MedCity
Belinda Nedjai, Mauro Perretti and Jack Cuzick
£3,738,555 Department of Health - GOV UK
01-11-2020 - 31-12-2025
bullet iconAdvancing Mesenchymal Stromal Cell-Dressing Therapy for Myocardial Repair
Ken Suzuki, Tom Nightingale, Mauro Perretti, Federica Marelli-Berg, Michael Barnes, Anthony Mathur and Fiona Lewis
£1,263,590 BHF British Heart Foundation
01-09-2020 - 31-05-2026
bullet iconThe Rising Stars Program
Mauro Perretti and David Kelsell
£6,137,969 Barts and the London Charity
01-01-2019 - 31-12-2025
bullet iconAP1189 as a novel therapeutic for human joint disease
Mauro Perretti
£192,488 WHRL William Harvey Research Limited
04-12-2012 - 31-12-2025

bullet iconArthritic Mice (STIA & KBxN F1 Samples)
Mauro Perretti
£12,821 WHRL William Harvey Research Limited
01-06-2024 - 31-05-2025
bullet iconDevelopment of safer ACTH-based drugs for autoimmune diseases
Trinidad Montero Melendez and Mauro Perretti
£72,632 AR-UK Versus Arthritis
01-08-2022 - 31-07-2023
bullet iconAP1189 in COVID - biomarker analyses
Mauro Perretti
£96,890 SynAct Pharma AB
01-03-2022 - 30-06-2022
bullet iconINBRX-101 for cartilage regeneration in osteoarthritis
Magdalena K Kaneva and Mauro Perretti
£97,499 INHIBRIX
01-02-2022 - 31-01-2024
bullet iconHORIZON-HLTH-2022-DISEASE-06-two-stage pump priming
Mauro Perretti and Stavros Fotiadis
£8,336 British Academy
01-01-2022 - 30-06-2022
bullet iconCardiomyopathyinRA
Mauro Perretti and Lucy Norling
£230,740 Bristol-Myers Squibb Pharmaceuticals Ltd
01-05-2021 - 31-12-2023
bullet iconNew therapeutic targets for treating the failing heart in arthritis.
Mauro Perretti and Dianne Cooper
£121,382 WHRF William Harvey Research Foundation
01-04-2021 - 31-03-2024
bullet iconCOVID 19 (LAMP) TESTING
Belinda Nedjai and Mauro Perretti
£2,304,261 NIHR National Institute for Health Research
21-03-2021 - 31-03-2022
bullet iconCovid-19 Support
Mauro Perretti
£50,000 MCSBHT Medical College of St Bartholomew's Hospital Trust
01-05-2020 - 30-04-2021
bullet iconA New Therapeutic Approach to Cardioprotection for Myocardial Infarct Patients
Mauro Perretti
£143,668 Barts and the London Charity
01-03-2020 - 31-08-2022
bullet iconMTA of FPR2 expressing cells from QMUL to Resother Pharma
Mauro Perretti
£5,000 ResoTher Pharma AS
01-05-2019 - 30-04-2020
bullet iconDevelopment of reparative macrophage transplantation for the treatment of myocardial infarction through refinement of current bone marrow mononuclear cell therapy
Ken Suzuki, Anthony Mathur, Fiona Lewis and Mauro Perretti
£289,890 BHF British Heart Foundation
01-04-2019 - 31-03-2022
bullet iconEstablishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis
Mauro Perretti and Lucy Norling
£225,258 EU Commission - Horizon 2020
01-03-2019 - 28-02-2023
bullet iconRe-programming pivotal cells with melanocortin receptor peptides
Mauro Perretti
£256,232 WHRL William Harvey Research Limited
01-01-2019 - 05-12-2024
bullet iconIdentifying novel receptor targets to control complex disease processes - ECIS Equipment
Magdalena Flak, Jesmond Dalli and Mauro Perretti
£45,000 Barts and the London Charity
01-09-2018 - 31-08-2019
bullet iconThe development and characterization of pro-resolving therapeutics as novel anti-inflammatory drugs
Mauro Perretti
£3,593 WHRF William Harvey Research Foundation
01-02-2018 - 31-01-2019
bullet iconNeutrophil Vesicles as a novel auto logous regenerative therapeutic for joint disease
Mauro Perretti
£235,902 MRC Medical Research Council
04-09-2017 - 03-09-2019
bullet iconTargeting Feutin-A as an innovative chondropretective strategy
Mauro Perretti
£315,406 WHRL William Harvey Research Limited
01-08-2017 - 31-12-2023
bullet iconThe molecular pharmacology of melanocortin receptor peptide agonists
Mauro Perretti
£151,948 WHRL William Harvey Research Limited
01-05-2017 - 30-11-2019
bullet iconCloning and Validation of an anti-arthritic ACTH species devoid of side effects
Mauro Perretti
£217,557 AR-UK Versus Arthritis
01-10-2016 - 30-09-2019
bullet iconEVOLuTION - European Vascular Interventions and Therapeutic Innovation Network
Mauro Perretti
£725,462 EU European Commission - Other
01-04-2016 - 31-03-2021
bullet iconTreating the host in Dengue: Mediators and pathways of resolution as a new therapeutic paradign
Mauro Perretti
£241,315 MRC Medical Research Council
14-01-2016 - 13-01-2019
bullet iconExploring the resolution of inflammation for innovative target discovery
Mauro Perretti
£162,290 WHRL William Harvey Research Limited
01-02-2012 - 31-12-2024