Publications

Publications of specific relevance to Predictive in vitro Models
2020

Hebeda CB, Sandri S, Benis CM, Paula-Silva MD, Loiola RA, Reutelingsperger C,
Perretti M and Farsky SHP (2020).
Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst. Cells vol. 9, (5)
10.3390/cells9051188
Corsiero E, Carlotti E, Jagemann L,
Perretti M, Pitzalis C and Bombardieri M (2020).
H and L chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity toward neutrophil extracellular trap antigens in rheumatoid arthritis synovial b cell clones. Journal of Immunology vol. 204, (9) 2374-2379.
10.4049/jimmunol.1901457
Norling LV and
Perretti M (2020).
Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of The National Academy of Sciences of The United States of America vol. 117, (17) 9148-9150.
10.1073/pnas.2004241117
McArthur S, Juban G, Gobbetti T, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP, Chazaud B,
Perretti M and Mounier R (2020).
Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation. Journal of Clinical Investigation vol. 130, (3) 1156-1167.
10.1172/JCI124635
Belvedere R, Pessolano E, Porta A, Tosco A, Parente L, Petrella F,
Perretti M and Petrella A (2020).
Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound healing. European Journal of Pharmacology vol. 869,
10.1016/j.ejphar.2019.172894
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C,
Law HL,
Perretti M,
Norling LV,
Azevedo HS and Nissim A (2020).
Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media Frontiers in Immunology vol. 11,
10.3389/fimmu.2020.00010
Montero Melendez T, Nagano A, Chelala C, Filer A, Buckley CD and
Perretti M (2020).
Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis. Nature Research (Part of Springer Nature) Nature Communications vol. 11, (1)
10.1038/s41467-020-14421-x
Machado MG, Tavares LP, Souza GVS, Queiroz-Junior CM, Ascenção FR, Lopes ME, Garcia CC, Menezes GB,
Perretti M, Russo RC, Teixeira MM and Sousa LP (2020).
The Annexin A1/FPR2 pathway controls the inflammatory response and bacterial dissemination in experimental pneumococcal pneumonia. Faseb Journal vol. 34, (2) 2749-2764.
10.1096/fj.201902172R
(2020).
Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Brain, Behavior, and Immunity 10.1016/j.bbi.2020.02.0152019

Barbosa CMV, Fock RA, Hastreiter AA, Reutelingsperger C,
Perretti M, Paredes-Gamero EJ and Farsky SHP (2019).
Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway. Cell Death Discovery vol. 5, (1)
10.1038/s41420-019-0215-1
Bizzarro V, Belvedere R, Pessolano E, Parente L, Petrella F,
Perretti M and Petrella A (2019).
Mesoglycan induces keratinocyte activation by triggering syndecan-4 pathway and the formation of the annexin A1/S100A11 complex. Journal of Cellular Physiology vol. 234, (11) 20174-20192.
10.1002/jcp.28618
Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P, Reutelingsperger CP, Naccache JM, Bonnotte B, Karras A, Puéchal X, Guillevin L, Terrier B, Frachet P,
Perretti M, Mouthon L and Witko-Sarsat V (2019).
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance. Kidney International vol. 96, (2) 397-408.
10.1016/j.kint.2019.02.017
Senchenkova EY, Ansari J, Becker F, Vital SA, Al-Yafeai Z, Sparkenbaugh EM, Pawlinski R, Stokes KY, Carroll JL, Dragoi AM, Qin CX, Ritchie RH, Sun H, Cuellar-Saenz HH, Rubinstein MR, Han YW, Orr AW,
Perretti M, Granger DN and Gavins FNE (2019).
Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation. Circulation vol. 140, (4) 319-335.
10.1161/CIRCULATIONAHA.118.039345
Salamah MF, Ravishankar D, Vaiyapuri R, Moraes LA, Patel K,
Perretti M, Gibbins JM and Vaiyapuri S (2019).
The formyl peptide fMLF primes platelet activation and augments thrombus formation. Journal of Thrombosis and Haemostasis vol. 17, (7) 1120-1133.
10.1111/jth.14466
Nadkarni S, Lashin H, Hollywood J, Dasgupta B, Mason JC and
Perretti M (2019).
Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: A potential involvement of immune cell cross-talk. Clinical Science vol. 133, (7) 839-851.
10.1042/CS20180415
(2019).
Formyl peptide receptor 1 signalling promotes experimental colitis in mice. Pharmacological Research vol. 141, 591-601.
10.1016/j.phrs.2019.01.041
Sugimoto MA, Vago JP,
Perretti M and Teixeira MM (2019).
Mediators of the Resolution of the Inflammatory Response. Trends in Immunology vol. 40, (3) 212-227.
10.1016/j.it.2019.01.007
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M,
Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P,
Perretti M, Godson C and Guiry PJ (2019).
Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). European Journal of Medicinal Chemistry vol. 162, 80-108.
10.1016/j.ejmech.2018.10.049
VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C,
PERRETTI M and NOURSHARGH S (2019).
Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. Wiley Journal of Pathology vol. 248, (1) 88-102.
10.1002/path.5234
Sinniah A, Yazid S, Bena S, Oliani SM,
Perretti M and Flower RJ (2019).
Endogenous annexin-A1 negatively regulates mast cell-mediated allergic reactions. Frontiers in Pharmacology vol. 10,
10.3389/fphar.2019.01313
Vago JP, Sugimoto MA, Lima KM, Negreiros-Lima GL, Baik N, Teixeira MM,
Perretti M, Parmer RJ, Miles LA and Sousa LP (2019).
Plasminogen and the plasminogen receptor, PLG-RKT, regulate macrophage phenotypic, and functional changes. Frontiers in Immunology vol. 10, (JUN)
10.3389/fimmu.2019.014582018

Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L,
Perretti M and Petrella A (2018).
Annexin A1 may induce pancreatic cancer progression as a key player of extracellular vesicles effects as evidenced in the in vitro MIA PaCa-2 model system. International Journal of Molecular Sciences vol. 19, (12)
10.3390/ijms19123878
Petri MH, Thul S, Andonova T, Lindquist-Liljeqvist M, Jin H, Skenteris NT, Arnardottir H, Maegdefessel L, Caidahl K,
Perretti M, Roy J and Bäck M (2018).
Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms. Jacc: Basic to Translational Science vol. 3, (6) 719-727.
10.1016/j.jacbts.2018.08.005
Salamah MF, Ravishankar D, Kodji X, Moraes LA, Williams HF, Vallance TM, Albadawi DA, Vaiyapuri R, Watson K, Gibbins JM, Brain SD,
Perretti M and Vaiyapuri S (2018).
The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation. Blood Advances vol. 2, (21) 2973-2985.
10.1182/bloodadvances.2018021758
Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K, Aronica E, Porcu L, Pistorius K, Colas RA, Hansen TV,
Perretti M, Kaminski RM, Dalli J and Vezzani A (2018).
n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain vol. 141, (11) 3130-3143.
10.1093/brain/awy247
Hebeda CB, Machado ID, Reif-Silva I, Moreli JB, Oliani SM, Nadkarni S,
Perretti M, Bevilacqua E and Farsky SHP (2018).
Endogenous annexin A1 (AnxA1) modulates early-phase gestation and offspring sex-ratio skewing. Journal of Cellular Physiology vol. 233, (9) 6591-6603.
10.1002/jcp.26258
Patruno S, Garrido-Mesa J, Romano M,
PERRETTI M and MONTERO MELENDEZ T (2018).
Ligand bias and its association with pro-resolving actions of melanocortin drugs. Frontiers Media Frontiers in Pharmacology vol. 9, (919)
10.3389/fphar.2018.00919
PITZALIS C, CORSIERO E, JAGEMANN L,
PERRETTI M and BOMBARDIERI M (2018).
Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints. American Association of Immunologists Journal of Immunology 10.4049/jimmunol.1800346
Piovezan AP and
Perretti M (2018).
Potential engagement of pathways of the resolution of inflammation as mechanism of action for plants on animal models. Journal of Ethnopharmacology vol. 221, 160-161.
10.1016/j.jep.2017.11.033
Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF,
Perretti M, Murphy AJ, Du XJ, Gao XM and Ritchie RH (2018).
Erratum: Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo (Scientific reports (2017) 7 1 (16615)). Scientific Reports vol. 8, (1)
10.1038/s41598-018-24994-9
Lashin HMS, Nadkarni S,
Oggero S, Jones HR, Knight JC, Hinds CJ and
Perretti M (2018).
Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis. Shock vol. 49, (4) 393-401.
10.1097/SHK.0000000000000989
(2018).
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Ebiomedicine vol. 29, 60-69.
10.1016/j.ebiom.2018.02.003
Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D,
Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S and Panigrahy D (2018).
Resolvins suppress tumor growth and enhance cancer therapy. Journal of Experimental Medicine vol. 215, (1) 115-140.
10.1084/jem.201706812017

Qin CX, Finlayson SB, Ai-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF,
Perretti M, Murphy AJ, Du X-J, Gao X-M and Ritchie RH (2017).
Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo. Macmillan Publishers Limited, Part of Springer Nature Sci Rep vol. 7, (1) 16615-16615.
10.1038/s41598-017-16317-1
Simeoli R, Montague K, Jones HR, Castaldi L, Chambers D, Kelleher JH, Vacca V, Pitcher T, Grist J, Al-Ahdal H, Wong L-F,
Perretti M, Lai J, Mouritzen P, Heppenstall P and Malcangio M (2017).
Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma. Macmillan Publishers Limited, Part of Springer Nature Nat Commun vol. 8, (1) 1778-1778.
10.1038/s41467-017-01841-5
Petri MH, Laguna-Fernandez A, Arnardottir H, Wheelock CE,
Perretti M, Hansson GK and Bäck M (2017).
Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E−/− mice. British Journal of Pharmacology vol. 174, (22) 4043-4054.
10.1111/bph.13707
Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF, Galvão I, Costa BRC, Soriani FM, Pinho V,
Solito E,
Perretti M, Teixeira MM and Sousa LP (2017).
The resolution of acute inflammation induced by cyclic AMP is dependent on Annexin A1. Journal of Biological Chemistry vol. 292, (33) 13758-13773.
10.1074/jbc.M117.800391
Gittens BR, Bodkin JV, Nourshargh S,
Perretti M and Cooper D (2017).
Galectin-3: A positive regulator of leukocyte recruitment in the inflamed microcirculation. Journal of Immunology vol. 198, (11) 4458-4469.
10.4049/jimmunol.1600709
Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP,
Norling LV, Cooper D, Headland S, Souza PRPS and
Perretti M (2017).
Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Journal of Ethnopharmacology vol. 204, 179-188.
10.1016/j.jep.2017.03.059
(2017).
Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide. Public Library of Science Plos One vol. 12, (4) e0175786-e0175786.
10.1371/journal.pone.0175786
(2017).
The impact of environmental enrichment on the murine inflammatory immune response. Jci Insight vol. 2, (7)
10.1172/jci.insight.90723
Montero-Melendez T, Forfar RAE, Cook JM, Jerman JC, Taylor DL and
Perretti M (2017).
Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cellular and Molecular Life Sciences vol. 74, (7) 1335-1345.
10.1007/s00018-016-2419-3
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and
Perretti M (2017).
Identification of novel chondroprotective mediators in resolving inflammatory exudates. Journal of Immunology vol. 198, (7) 2876-2885.
10.4049/jimmunol.1601111
PERRETTI M, Dalli J, Colas R, Federici Canova D and Gobbetti T (2017).
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 114, (15) 3963-3968.
10.1073/pnas.1617290114
Simeoli R, Mattace Raso G, Pirozzi C, Lama A, Santoro A, Russo R, Montero-Melendez T, Berni Canani R, Calignano A,
Perretti M and Meli R (2017).
An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis. British Journal of Pharmacology vol. 174, (11) 1484-1496.
10.1111/bph.136372016

NADKARNI SA, Smith J, Mauro C, Marelli-Berg FM,
Perretti M, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Williams DJ and Farsky S (2016).
Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy., Editors: Medzhitov R.
National Academy of Sciences Proceedings of The National Academy of Sciences of Usa 10.1073/pnas.1611944114
Machado ID, Spatti M, Hastreiter A, Santin JR, Fock RA, Gil CD, Oliani SM,
Perretti M and Farsky SHP (2016).
Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway. Journal of Cellular Physiology vol. 231, (11) 2418-2427.
10.1002/jcp.25346
Arnardottir HH, Dalli J,
Norling LV, Colas RA,
Perretti M and Serhan CN (2016).
Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists Journal of Immunology vol. 197, (6) 2362-2368.
10.4049/jimmunol.1502268
Madeira MFM, Queiroz-Junior CM, Montero-Melendez T, Werneck SMC, Correa JD, Soriani FM, Garlet GP, Souza DG, Teixeira MM, Silva TA and
Perretti M (2016).
Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection. Federation of American Society of Experimental Biology (Faseb) The Faseb Journal 10.1096/fj.201600790R
(2016).
Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Annals of The Rheumatic Diseases vol. 75, (6) 1228-1235.
10.1136/annrheumdis-2015-207316
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N,
Perretti M,
Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016).
IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology Journal of The American Society of Nephrology 10.1681/ASN.2015060670
Vital SA, Becker F, Holloway PM, Russell J,
Perretti M, Granger DN and Gavins FNE (2016).
Fpr2/ALX Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease. American Heart Association Circulation 10.1161/CIRCULATIONAHA.115.020633
Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T,
Perretti M, Papapetropoulos A, Bucci M and Cirino G (2016).
D -Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase. British Journal of Pharmacology vol. 173, (9) 1556-1565.
10.1111/bph.13459
Sugimoto MA, Sousa LP, Pinho V,
Perretti M and Teixeira MM (2016).
Resolution of Inflammation: What Controls Its Onset? Frontiers Media Frontiers in Immunology vol. 7,
10.3389/fimmu.2016.00160
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and
Perretti M (2016).
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. Jci Insight vol. 1, (5)
10.1172/jci.insight.85922
Sinniah A, Yazid S,
Perretti M,
Solito E and Flower RJ (2016).
The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. International Immunopharmacology vol. 32, 87-95.
10.1016/j.intimp.2016.01.003
Vago JP, Tavares LP, Sugimoto MA, Lima GLN, Galvaõ I, De Caux TR, Ia L, Ribeiro ALC, Carneiro FS, Nunes FFC, Pinho V,
Perretti M, Teixeira MM and Sousa LP (2016).
Proresolving actions of synthetic and natural protease inhibitors are mediated by annexin A1. Journal of Immunology vol. 196, (4) 1922-1932.
10.4049/jimmunol.1500886
(2016).
Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Mediators of Inflammation vol. 2016,
10.1155/2016/73683892015

(2015).
Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Science Translational Medicine vol. 7, (315)
10.1126/scitranslmed.aac5608
Canova DF, Pavlov AM,
Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and
Perretti M (2015).
Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Journal of Controlled Release vol. 217, 284-292.
10.1016/j.jconrel.2015.09.021
Perretti M, Leroy X, Bland EJ and Montero-Melendez T (2015).
Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation. Trends in Pharmacological Sciences vol. 36, (11) 737-755.
10.1016/j.tips.2015.07.007
Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW,
Perretti M, Getting SJ and Gavins FNE (2015).
Both MC1 and MC3 receptors provide protection from cerebral ischemia-reperfusion-induced neutrophil recruitment. Arteriosclerosis, Thrombosis, and Vascular Biology vol. 35, (9) 1936-1944.
10.1161/ATVBAHA.115.305348
Kusters DHM, Chatrou ML, Willems BAG, De Saint-Hubert M, Bauwens M, Van Der Vorst E, Bena S, Biessen EAL,
Perretti M, Schurgers LJ and Reutelingsperger CPM (2015).
Pharmacological treatment with annexin A1 reduces atherosclerotic plaque burden in LDLR-/- mice on Western Type Diet. Plos One vol. 10, (6)
10.1371/journal.pone.0130484
Trentin PG, Ferreira TPT, Arantes ACS, Ciambarella BT, Cordeiro RSB, Flower RJ,
Perretti M, Martins MA and Silva PMR (2015).
Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice. British Journal of Pharmacology vol. 172, (12) 3058-3071.
10.1111/bph.13109
Amoruso A, Fresu LG, Dalli J, Miglietta D, Bardelli C, Canova DF,
Perretti M and Brunelleschi S (2015).
Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen. Life Sciences vol. 126, 28-36.
10.1016/j.lfs.2015.01.025
Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TE and
Perretti M (2015).
Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. The American Association of Immunologists, Inc. J Immunol vol. 194, (7) 3381-3388.
10.4049/jimmunol.1402645
Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H,
Perretti M, Vergnolle N and Cenac N (2015).
Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. Br J Pharmacol vol. 172, (3) 910-923.
10.1111/bph.12957
Petri MH, Laguna-Fernandez A, Tseng CN, Hedin U,
Perretti M and Bäck M (2015).
Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation. International Journal of Cardiology vol. 179, 370-372.
10.1016/j.ijcard.2014.11.010
Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G,
Perretti M, Farokzhad O and Tabas I (2015).
Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Science Translational Medicine vol. 7, (275)
10.1126/scitranslmed.aaa1065
Leoni G, Neumann PA, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C,
Perretti M, Parkos CA, Farokhzad OC, Neish AS and Nusrat A (2015).
Annexin A1'containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. Journal of Clinical Investigation vol. 125, (3) 1215-1227.
10.1172/JCI76693
Perretti M (2015).
The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology. Seminars in Immunology vol. 27, (3) 145-148.
10.1016/j.smim.2015.06.001
McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ and
Perretti M (2015).
Definition of a novel pathway centered on lysophosphatidic acid to recruit monocytes during the resolution phase of tissue inflammation. Journal of Immunology vol. 195, (3) 1139-1151.
10.4049/jimmunol.1500733
Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D Acquisto F, Bland EJ, Bombardieri M, Pitzalis C,
Perretti M, Marelli-Berg FM and Mauro C (2015).
Lactate regulates metabolic and proinflammatory circuits in control of T cell migration and effector functions. Plos Biology vol. 13, (7)
10.1371/journal.pbio.10022022014

Gobbetti T, Coldewey SM, Chen J, McArthur S, Le Faouder P, Cenac N, Flower RJ, Thiemermann C and
Perretti M (2014).
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of The National Academy of Sciences of The United States of America vol. 111, (52) 18685-18690.
10.1073/pnas.1410938111
Thompson D, McArthur S, Hislop JN, Flower RJ and
Perretti M (2014).
Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: association with cell protection from apoptosis. J Biol Chem vol. 289, (52) 36166-36178.
10.1074/jbc.M114.612630
(2014).
Formyl peptide receptor as a novel therapeutic target for anxiety-related disorders. Plos One vol. 9, (12)
10.1371/journal.pone.0114626
Machado ID, Santin JR, Drewes CC, Gil CD, Oliani SM,
Perretti M and Farsky SHP (2014).
Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions. Am J Physiol Endocrinol Metab vol. 307, (9) E754-E763.
10.1152/ajpendo.00227.2014
Brancaleone V, Mitidieri E, Flower RJ, Cirino G and
Perretti M (2014).
Annexin A1 mediates hydrogen sulfide properties in the control of inflammation. J Pharmacol Exp Ther vol. 351, (1) 96-104.
10.1124/jpet.114.217034
(2014).
Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol vol. 91, (3) 348-358.
10.1016/j.bcp.2014.07.034
Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M,
Norling L, Biessen EAL, Cleutjens J,
Perretti M, Schurgers LJ and Reutelingsperger CPM (2014).
AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine vol. 18, (10) 2117-2124.
10.1111/jcmm.12374
Montero-Melendez T and
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Gapdh gene expression is modulated by inflammatory arthritis and is not suitable for qPCR normalization. Inflammation vol. 37, (4) 1059-1069.
10.1007/s10753-014-9829-x
Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D and
Perretti M (2014).
Resolution of inflammation: examples of peptidergic players and pathways. Drug Discov Today vol. 19, (8) 1166-1171.
10.1016/j.drudis.2014.05.020
Montero-Melendez T, Madeira MFM,
Norling LV, Alsam A, Curtis MA, da Silva TA and
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Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol vol. 184, (8) 2333-2341.
10.1016/j.ajpath.2014.04.009
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S, Parola M, Paternostro C, Bugianesi E, McArthur S, Albano E and
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Endogenous Annexin A1 Is a Novel Protective Determinant in Nonalcoholic Steatohepatitis in Mice. Hepatology vol. 60, (2) 531-544.
10.1002/hep.27141
(2014).
Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep vol. 4,
10.1038/srep05237
Old EA, Nadkarni S, Grist J, Gentry C, Bevan S, Kim K-W, Mogg AJ,
Perretti M and Malcangio M (2014).
Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. Journal of Clinical Investigation vol. 124, (5) 2023-2036.
10.1172/JCI71389
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ, Cooper D,
Perretti M and Marelli-Berg FM (2014).
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun vol. 5,
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Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B and
Perretti M (2014).
Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression. Circ Res vol. 114, (2) 242-248.
10.1161/CIRCRESAHA.114.301374
Dalli J,
Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and
Perretti M (2014).
Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. Embo Mol Med vol. 6, (1) 27-42.
10.1002/emmm.2013035032013

Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ and
Perretti M (2013).
Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A vol. 110, (45) 18232-18237.
10.1073/pnas.1308253110
Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V and
Perretti M (2013).
Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. Embo Rep vol. 14, (11) 999-1007.
10.1038/embor.2013.138
Dalli J, Montero-Melendez T,
Norling LV, Yin X, Hinds C, Haskard D, Mayr M and
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Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219.
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Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S and
Perretti M (2013).
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood vol. 122, (4) 608-617.
10.1182/blood-2013-04-496661
Iqbal AJ, Cooper D, Vugler A, Gittens BR, Moore A and
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Endogenous galectin-1 exerts tonic inhibition on experimental arthritis. J Immunol vol. 191, (1) 171-177.
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Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor. J Immunol vol. 190, (12) 6478-6487.
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Ortega-Gomez A,
Perretti M and Soehnlein O (2013).
Resolution of inflammation: an integrated view. Embo Molecular Medicine vol. 5, (5) 661-674.
10.1002/emmm.201202382
Fowkes RC, Moradi-Bidhendi N, Branceleone V, Zariwala MG, Brady D, Jessop DS,
Perretti M and Renshaw D (2013).
Annexin-A1 protein and its relationship to cortisol in human saliva. Psychoneuroendocrinology vol. 38, (5) 722-727.
10.1016/j.psyneuen.2012.08.003
Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP,
Perretti M, Corrigan OI and Brayden DJ (2013).
An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis. J Control Release vol. 167, (2) 120-129.
10.1016/j.jconrel.2013.01.027
Montero-Melendez T, Dalli J and
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Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. Cell Death Differ vol. 20, (4) 567-575.
10.1038/cdd.2012.154
Rhodes DH, Pini M, Castellanos KJ, Montero-Melendez T, Cooper D,
Perretti M and Fantuzzi G (2013).
Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function. Obesity (Silver Spring) vol. 21, (2) 310-319.
10.1002/oby.20016
Schutters K, Kusters DHM, Chatrou MLL, Montero-Melendez T, Donners M, Deckers NM, Krysko DV, Vandenabeele P,
Perretti M, Schurgers LJ and Reutelingsperger CPM (2013).
Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death Differ vol. 20, (1) 49-56.
10.1038/cdd.2012.107
Kosicka A, Cunliffe AD, Mackenzie R, Zariwala MG,
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Attenuation of plasma annexin A1 in human obesity. Faseb Journal vol. 27, (1) 368-378.
10.1096/fj.12-213728
Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N and
Perretti M (2013).
The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis. Plos One vol. 8, (2)
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Ahmed TJ, Montero-Melendez T,
Perretti M and Pitzalis C (2013).
Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides. Int J Inflam vol. 2013,
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Leoni G, Alam A, Neumann P-A, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K, Murthy N, Kusters D, Reutelingsperger C,
Perretti M, Parkos CA, Neish AS and Nusrat A (2013).
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. Journal of Clinical Investigation vol. 123, (1) 443-454.
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Pang J, Rhodes DH, Pini M, Akasheh RT, Castellanos KJ, Cabay RJ, Cooper D,
Perretti M and Fantuzzi G (2013).
Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. Plos One vol. 8, (2)
10.1371/journal.pone.0057915
Viiri LE, Full LE, Navin TJ, Begum S, Didangelos A, Astola N, Berge RK, Seppala I, Shalhoub J, Franklin IJ,
Perretti M, Lehtimaki T, Davies AH, Wait R and Monaco C (2013).
Smooth muscle cells in human atherosclerosis: Proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease. Journal of Molecular and Cellular Cardiology vol. 54, 65-72.
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Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression. Mediators Inflamm vol. 2013,
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Montero-Meléndez T, Llor X, García-Planella E,
Perretti M and Suárez A (2013).
Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling. Plos One vol. 8, (10)
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(2012).
The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Ann Rheum Dis vol. 71, (11) 1872-1880.
10.1136/annrheumdis-2011-201180
Cardini S, Dalli J, Fineschi S,
Perretti M, Lungarella G and Lucattelli M (2012).
Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice. American Journal of Respiratory Cell and Molecular Biology vol. 47, (3) 332-339.
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Editorial: to resolve or not to resolve: annexin A1 pushes resolution on track. J Leukoc Biol vol. 92, (2) 245-247.
10.1189/jlb.0312128
Norling LV, Dalli J, Flower RJ, Serhan CN and
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Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol vol. 32, (8) 1970-1978.
10.1161/ATVBAHA.112.249508
Bena S, Brancaleone V, Wang JM,
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Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling. J Biol Chem vol. 287, (29) 24690-24697.
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Distinct localization of T cell Agrin during antigen presentation--evidence for the expression of Agrin receptor(s) in antigen-presenting cells. Febs J vol. 279, (13) 2368-2380.
10.1111/j.1742-4658.2012.08615.x
Vong L, Ferraz JGP,
Dufton N, Panaccione R, Beck PL, Sherman PM,
Perretti M and Wallace JL (2012).
Up-Regulation of Annexin-A1 and Lipoxin A(4) in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis. Plos One vol. 7, (6)
10.1371/journal.pone.0039244
Leinster DA, Kulbe H, Everitt G, Thompson R,
Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and
Balkwill FR (2012).
The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol vol. 227, (2) 136-145.
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Clark AK, Grist J, Al-Kashi A,
Perretti M and Malcangio M (2012).
Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model. Arthritis and Rheumatism vol. 64, (6) 2038-2047.
10.1002/art.34351
Liverani E, Banerjee S, Roberts W, Naseem KM and
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Prednisolone exerts exquisite inhibitory properties on platelet functions. Biochem Pharmacol vol. 83, (10) 1364-1373.
10.1016/j.bcp.2012.02.006
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The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Annals of The Rheumatic Diseases 10.1136/annrheumdis-2011-201180
Cooper D, Iqbal AJ, Gittens BR, Cervone C and
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The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? Ann N Y Acad Sci vol. 1253, 181-192.
10.1111/j.1749-6632.2011.06291.x
Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD,
Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML and Nourshargh S (2012).
Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves. Faseb J vol. 26, (3) 1064-1076.
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Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn-Schmiedebergs Archives of Pharmacology vol. 385, (2) 137-144.
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de Lima CB, Tamura EK, Montero-Melendez T, Palermo-Neto J,
Perretti M, Markus RP and Farsky SHP (2012).
Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling. Biochem Biophys Res Commun vol. 417, (2) 918-923.
10.1016/j.bbrc.2011.12.078
Dalli J, Jones CP, Cavalcanti DM, Farsky SH,
Perretti M and Rankin SM (2012).
Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. Faseb J vol. 26, (1) 387-396.
10.1096/fj.11-182089
Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed M,
Perretti M and Chernajovsky Y (2012).
Molecular engineering of short half-life small peptides (VIP, αMSH and γ₃MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics. Ann Rheum Dis vol. 71, (1) 143-149.
10.1136/annrheumdis-2011-200100
Dalli J, Montero-Melendez T, McArthur S and
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Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol vol. 3,
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Mapping pathogenesis of arthritis through small animal models. Rheumatology (United Kingdom) vol. 51, (11) 1931-1941.
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High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents. Biochem Pharmacol vol. 82, (12) 1919-1929.
10.1016/j.bcp.2011.09.009
Nadkarni S, Cooper D, Brancaleone V, Bena S and
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Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes. Arterioscler Thromb Vasc Biol vol. 31, (11) 2749-2759.
10.1161/ATVBAHA.111.235176
Damazo AS, Sampaio AL, Nakata CM, Flower RJ,
Perretti M and Oliani SM (2011).
Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis. Bmc Immunol vol. 12,
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Patel HB, Montero-Melendez T, Greco KV and
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Melanocortin receptors as novel effectors of macrophage responses in inflammation., Editors: Ariel A.
Frontiers in Immunology vol. 2, 1-6.
10.3389/fimmu.2011.00041
Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TEN and
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The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties. Am J Pathol vol. 179, (1) 259-269.
10.1016/j.ajpath.2011.03.042
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Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. J Pharmacol Exp Ther vol. 337, (3) 830-837.
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IL-17A increases ADP-induced platelet aggregation. Biochem Biophys Res Commun vol. 408, (4) 658-662.
10.1016/j.bbrc.2011.04.080
Norling LV, Spite M, Yang R, Flower RJ,
Perretti M and Serhan CN (2011).
Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. Journal of Immunology vol. 186, (10) 5543-5547.
10.4049/jimmunol.1003865
Norling LV, Spite M, Yang R, Flower RJ,
Perretti M and Serhan CN (2011).
Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J Immunol vol. 186, (10) 5543-5547.
10.4049/jimmunol.1003865
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL,
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Hobbs AJ and Ahluwalia A (2011).
Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol vol. 31, (5) 1075-1083.
10.1161/ATVBAHA.111.223545
Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G and
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Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol vol. 186, (8) 4905-4914.
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Montero-Melendez T, Patel HB and
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Role of melanocortin receptors in the regulation of gouty inflammation. Curr Rheumatol Rep vol. 13, (2) 138-145.
10.1007/s11926-011-0163-0
Iqbal AJ, Sampaio ALF, Maione F, Greco KV, Niki T, Hirashima M,
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Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. Am J Pathol vol. 178, (3) 1201-1209.
10.1016/j.ajpath.2010.11.073
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Anti-inflammatory role of the murine formyl-peptide receptor 2: Ligand-specific effects on leukocyte responses and experimental in-flammation (The Journal of Immunology (2010) 184, (2611-2619)). Journal of Immunology vol. 186, (4) 2684-2685.
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Cross-talk between minimally primed HL-60 cells and resting HUVEC reveals a crucial role for adhesion over extracellularly released oxidants. Biochem Pharmacol vol. 81, (3) 396-401.
10.1016/j.bcp.2010.10.018
Colucci M, Mastriota M, Maione F, Di Giannuario A, Mascolo N, Palmery M, Severini C,
Perretti M and Pieretti S (2011).
Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids. Peptides vol. 32, (2) 266-271.
10.1016/j.peptides.2010.11.019
Patel HB, Montero-Melendez T, Greco KV and
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Melanocortin receptors as novel effectors of macrophage responses in inflammation. Front Immunol vol. 2,
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An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse. Lab Invest vol. 91, (1) 33-42.
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Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells. Autoimmunity vol. 43, (8) 672-681.
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Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. Faseb J vol. 24, (12) 4835-4843.
10.1096/fj.10-167759
Canaider S, Vettraino M,
Norling LV, Spisni E, Facchin F, Cooper D and
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Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918.
10.3892/ijmm_00000542
Canaider S, Vettraino M,
Norling LV, Spisni E, Facchin F, Cooper D and
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Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918.
10.3892/ijmm_00000542
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Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature. Blood vol. 116, (20) 4288-4296.
10.1182/blood-2010-02-270520
Maderna P, Cottell DC, Toivonen T,
Dufton N, Dalli J,
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FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. Faseb J vol. 24, (11) 4240-4249.
10.1096/fj.10-159913
Yazid S, Leoni G, Getting SJ, Cooper D,
Solito E,
Perretti M and Flower RJ (2010).
Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol vol. 30, (9) 1718-1724.
10.1161/ATVBAHA.110.209536
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CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway. Am J Pathol vol. 177, (1) 176-186.
10.2353/ajpath.2010.091149
Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF and
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Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. J Leukoc Biol vol. 87, (5) 877-884.
10.1189/jlb.1009670
Leoni G, Voisin M-B, Carlson K, Getting S, Nourshargh S and
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The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. Br J Pharmacol vol. 160, (1) 171-180.
10.1111/j.1476-5381.2010.00688.x
Semple F, Webb S, Li HN, Patel HB,
Perretti M, Jackson IJ, Gray M, Davidson DJ and Dorin JR (2010).
Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. Eur J Immunol vol. 40, (4) 1073-1078.
10.1002/eji.200940041
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Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J Immunol vol. 184, (5) 2611-2619.
10.4049/jimmunol.0903526
Sarndahl E, Bergstrom I, Nijm J, Forslund T,
Perretti M and Jonasson L (2010).
Enhanced neutrophil expression of annexin-1 in coronary artery disease. Metabolism vol. 59, (3) 433-440.
10.1016/j.metabol.2009.07.044
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Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. Cell Cycle vol. 9, (4) 785-794.
10.4161/cc.9.4.10673
Hunter C, Kadakia TB, Cooper D,
Perretti M, Schwartz RC and Brown SB (2010).
Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands. Thescientificworldjournal vol. 10, 1580-1596.
10.1100/tsw.2010.155
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The Cardio-Protective Properties of Ncx-6550, a Nitric Oxide Donating Pravastatin, in the Mouse. Microcirculation vol. 17, (6) 417-426.
10.1111/j.1549-8719.2010.00040.x
Cooper D, Ilarregui JM, Pesoa SA, Croci DO,
Perretti M and Rabinovich GA (2010).
Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate. 10.1016/S0076-6879(10)80011-4
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Comparative analysis of Annexin A1-Formyl Peptide Receptor 2/ALX expression in human leukocyte subsets. Elsevier International Immunopharmacology vol. 11, (1) 55-66.
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Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1. J Neuroinflammation vol. 6,
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Hobbs AJ,
Perretti M and Ahluwalia A (2009).
Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol vol. 29, (11) 1757-1763.
10.1161/ATVBAHA.109.191775
Spite M,
Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ,
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Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature vol. 461, (7268) 1287-U125.
10.1038/nature08541
McColl A, Bournazos S, Franz S,
Perretti M, Morgan BP, Haslett C and Dransfield I (2009).
Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages. J Immunol vol. 183, (3) 2167-2175.
10.4049/jimmunol.0803503
Piqueras L, Sanz MJ,
Perretti M, Morcillo E,
Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009).
Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukocyte Biol vol. 86, (1) 115-122.
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Patel HB, Bombardieri M, Pitzalis C and
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Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis. Eur J Clin Invest vol. 39, 29-29.

(2009).
The impact of Annexin-A1 cleavage on neutrophil behaviour during vascular inflammation. Eur J Clin Invest vol. 39, 37-37.

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Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. Faseb J vol. 23, (4) 985-996.
10.1096/fj.08-119040
Tripatara P, Patel NSA, Brancaleone V, Renshaw D, Rocha J, Sepodes B, Mota-Filipe H,
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Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. Eur J Pharmacol vol. 606, (1-3) 205-209.
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Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol vol. 77, (5) 878-887.
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Hecht I, Rong J, Sampaio ALF, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, Cojocaru G, Zauberman A, Rotman G,
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A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects. J Pharmacol Exp Ther vol. 328, (2) 426-434.
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Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation. Am J Pathol vol. 174, (1) 177-183.
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Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol vol. 9, (1) 62-70.
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Quantitative Analysis of Promoter Activity by Green Fluorescent Protein (GFP) Target/Reporter Strategy in a Novel Transgenic alx/fpr-rs2 Null Mouse. Inflammation Research vol. 58, (2) S252-S255.
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Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP,
Perretti M and Spina D (2008).
A role for MC3R in modulating lung inflammation. Pulm Pharmacol Ther vol. 21, (6) 866-873.
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Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. Faseb J vol. 22, (12) 4228-4238.
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Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ,
Perretti M, Parkos CA and Nusrat A (2008).
Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol vol. 181, (7) 5035-5044.
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Oliani SM, Ciocca GAP, Pimentel TA, Damazo AS, Gibbs L and
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Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation. Inflamm Res vol. 57, (10) 450-456.
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Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. Brit J Pharmacol vol. 155, (2) 152-169.
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Initial characterisation of the novel transgenic, the alx/fpr-rs2 null mouse. Fund Clin Pharmacol vol. 22, 48-48.

Cooper D,
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Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukocyte Biol vol. 83, (6) 1459-1466.
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Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells. Rheumatology (Oxford) vol. 47, (5) 636-639.
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ENHANCED NEUTROPHIL EXPRESSION OF ANNEXIN-1 IN CORONARY ARTERY DISEASE. Atherosclerosis Supp vol. 9, (1) 15-15.
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Yona S, Lin HH, Dri P, Davies JQ, Hayhoe RPG, Lewis SM, Heinsbroek SEM, Brown KA,
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Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. Faseb J vol. 22, (3) 741-751.
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Annexin-1 modulates repair of gastric mucosal injury. Am J Physiol-Gastr L vol. 294, (3) G764-G769.
10.1152/ajpgi.00531.20072007

Finney SJ, Anning PB, Cao TV,
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Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion. Biochem Bioph Res Co vol. 364, (4) 831-837.
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Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. Eur J Immunol vol. 37, (11) 3131-3142.
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Annexin 1 cleavage in activated neutrophils - A pivotal role for proteinase 3. J Biol Chem vol. 282, (41) 29998-30004.
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A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. J Immunol vol. 179, (7) 4849-4856.
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Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. Faseb J vol. 21, (8) 1751-1758.
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Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow. J Pharmacol Exp Ther vol. 321, (2) 656-662.
10.1124/jpet.106.117218
John CD, Sahni V, Mehet D, Morris JF, Christian HC,
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Solito E and Buckingham JC (2007).
Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. Faseb J vol. 21, (4) 1037-1046.
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Uneven modulation of the annexin 1 system in osteoblast-like cells by dexamethasone. Biochem Bioph Res Co vol. 354, (2) 414-419.
10.1016/j.bbrc.2006.12.224
Mancini L, Paul-Clark MJ, Rosignoli G, Hannon R, Martin JE, Macintyre I and
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Calcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritis. Am J Pathol vol. 170, (3) 1018-1027.
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Resolution of inflammation: state of the art, definitions and terms. Faseb J vol. 21, (2) 325-332.
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Getting SJ, Lam CW, Leoni G, Gavins FNE, Grieco P and
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[D-Trp(8)]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol Pharmacol vol. 70, (6) 1850-1855.
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Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes. Biochem Biophys Res Commun vol. 349, (4) 1351-1355.
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Melanocortin 3 receptors control crystal-induced inflammation. Faseb J vol. 20, (13) 2234-2241.
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Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ,
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Antiflammin-2 activates the human formyl-peptide receptor like 1. Scientificworldjournal vol. 6, 1375-1384.
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Anti-inflammatory and analgesic aspects of the annexin A1 system. Acta Pharmacol Sin vol. 27, (9) 1272-1272.

Cassatella MA and
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Immunomodulation. The promises of immunopharmacology for the development of new drugs. Current Opinion in Pharmacology vol. 6, (4) 376-378.
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Annexin 1, anti-inflammatory drugs and the neuroendocrine-immune interface. Acta Pharmacol Sin vol. 27, 13-14.

Yona S, Heinsbroek SEM, Peiser L, Gordon S,
Perretti M and Flower RJ (2006).
Impaired phagocytic mechanism in annexin 1 null macrophages. Brit J Pharmacol vol. 148, (4) 469-477.
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Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptor. Inflamm Allergy Drug Targets vol. 5, (2) 107-114.
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Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. Cell Biol Int vol. 30, (4) 338-344.
10.1016/j.cellbi.2005.12.010
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Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J Immunol vol. 176, (7) 4410-4418.
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Hayhoe RPG, Kamal AM,
Solito E, Flower RJ, Cooper D and
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Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood vol. 107, (5) 2123-2130.
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The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. Eur J Pharmacol vol. 532, (1-2) 138-144.
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Inflammation-induced modulation of cellular galectin-1 and –3 expression in a model of rat peritonitis. Inflammation Research vol. 55, (3) 99-107.
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Therapeutic exploitation of endogenous anti-inflammatory mechanisms: Old and new leads. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry vol. 5, (4) 289-305.
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PERRETTI M, Nusrat A, Akyildiz A, Parkos CA, Babbin BA, Lee WY and Winfree LM (2006).
Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem vol. 281, 19588-19599.
10.1074/jbc.M5130252002005

Moraes LA, Paul-Clark MJ, Rickman A, Flower RJ, Goulding NJ and
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Ligand-specific glucocorticoid receptor activation in human platelets. Blood vol. 106, (13) 4167-4175.
10.1182/blood-2005-04-1723
Bensalem N, Ventura AP, Vallee B, Lipecka J, Tondelier D, Davezac N, Dos Santos A,
Perretti M, Fajac A, Sermet-Gaudelus I, Renouil M, Lesure JF, Halgand F, Laprevote O and Edelman A (2005).
Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. Mol Cell Proteomics vol. 4, (10) 1591-1601.
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A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor. Prostaglandins Leukot Essent Fatty Acids vol. 73, (3-4) 211-219.
10.1016/j.plefa.2005.05.008
Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ and
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Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol vol. 78, (3) 639-646.
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Yona S, Heinsbroek S, Gordon S,
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A novel role for Annexin 1 in macrophage phagocytosis. Inflamm Res vol. 54, S217-S218.
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Marchand F,
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Role of the immune system in chronic pain. Nat Rev Neurosci vol. 6, (7) 521-532.
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Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation. Am J Pathol vol. 166, (6) 1607-1617.
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Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide AC(2-26). J Immunol vol. 174, (6) 3727-3733.
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Kamal AM, Flower RJ and
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An overview of the effects of annexin 1 on cells involved in the inflammatory process. Mem Inst Oswaldo Cruz vol. 100 Suppl 1, 39-47.
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Zanardo RCO,
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Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage. Am J Physiol-Gastr L vol. 288, (3) G481-G486.
10.1152/ajpgi.00299.2004
Basoni C, Nobles M, Grimshaw A, Desgranges C, Davies D,
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Inhibitory control of TGF-beta 1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes. Faseb J vol. 19, (3) 822-+.
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Lam CW, Getting SJ and
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In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. J Immunol vol. 174, (4) 2297-2304.
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Yona S, Ward B, Buckingham JC,
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Macrophage biology in the Anx-A1-/- mouse. Prostaglandins Leukot Essent Fatty Acids vol. 72, (2) 95-103.
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PERRETTI M, Diaz BL, Bandeira-Melo C, Martins MA, Carvalho VF, Silva PM, Jose PJ and Bonavita AG (2005).
A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat. J Pharmacol Exp Ther vol. 313, (3) 1416-1422.
10.1124/jpet.104.080473
Alam CAS, Seed MP, Freemantle C, Brown J,
Perretti M, Carrier M, Divwedi A, West DC, Gustafson S, Colville-Nash PR and Willoughby DA (2005).
The inhibition of neutrophil-endothelial cell adhesion by hyaluronan independent of CD44. Inflammopharmacology vol. 12, (5-6) 535-550.
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Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct. Faseb J vol. 19, (1) 100-102.
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Cao TV, La M, Getting SJ, Day AJ and
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Inhibitory effects of TSG-6 link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation vol. 11, (7) 615-624.
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MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. J Leukocyte Biol vol. 76, (4) 845-853.
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The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1. J Pharmacol Exp Ther vol. 310, (3) 1133-1141.
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Yona S, Buckingham JC,
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Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. Br J Pharmacol vol. 142, (5) 890-898.
10.1038/sj.bjp.0705858
MARTIN JE, Flower RJ,
Perretti M, Hannon R, Getting SJ, Gavins FNE, Christian HC, Parente L, Paul-Clark MJ, Yona S, Oliani SM, Wells D, Cover PO, John CD, Solito E, Morris JF, Buckingham JC, Wells K, Liu K, Croxtall JD and Damazo AS (2004).
The Annexin 1-/- Mouse: Phenotypic Studies. Annexins vol. 1, (2) 109-120.

Pieretti S, Di Giannuario A, De Felice M,
Perretti M and Cirino G (2004).
Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides. Pain vol. 109, (1-2) 52-63.
10.1016/j.pain.2004.01.009
Gilroy DW, Lawrence T,
Perretti M and Rossi AG (2004).
Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov vol. 3, (5) 401-416.
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Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD,
Perretti M and Nourshargh S (2004).
Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol vol. 172, (7) 4493-4502.
10.4049/jimmunol.172.7.4493
Yang YH, Morand EF, Getting SJ, Paul-Clark M, Liu DL, Yona S, Hannon R, Buckingham JC,
Perretti M and Flower RJ (2004).
Modulation of inflammation and response to dexamethasone by annexin 1 in antigen-induced arthritis. Arthritis Rheum vol. 50, (3) 976-984.
10.1002/art.20201
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A,
Perretti M, Moncada S and
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Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. P Natl Acad Sci Usa vol. 101, (5) 1386-1391.
10.1073/pnas.0304264101
Baraldi PG, Romagnoli R, Nunez MD,
Perretti M, Paul-Clark MJ, Ferrario M, Govoni M, Benedini F and Ongini E (2004).
Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide. J Med Chem vol. 47, (3) 711-719.
10.1021/jm030964b
Moraes LA, Giner RM, Paul-Clark MJ,
Perretti M and Perrett D (2004).
An isocratic HPLC method for the quantitation of eicosanoids in human platelets. Biomed Chromatogr vol. 18, (1) 64-68.
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PERRETTI M, Oliani SM, Takahashi HK, Damazo AS, Paul-Clark MJ and Straus AH (2004).
Analysis of annexin 1 expression in rat trachea: study of mast cell heterogeneity. Annexins vol. 1, 12-18.
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La M, Cao TV, Cerchiaro G, Chilton K, Hirabayashi J, Kasao K, Oliani SM, Chernajovsky Y and
Perretti M (2003).
A novel biological activity for galectin-1 - Inhibition of leukocyte-endothelial cell interactions in experimental inflammation. Am J Pathol vol. 163, (4) 1505-1515.
10.1016/s0002-9440(10)63507-9
Paul-Clark MJ, Roviezzo F, Flower RJ, Cirino G, Del Soldato P, Adcock IM and
Perretti M (2003).
Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J Immunol vol. 171, (6) 3245-3252.
10.4049/jimmunol.171.6.3245
Getting SJ, Schioth HB and
Perretti M (2003).
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. J Pharmacol Exp Ther vol. 306, (2) 631-637.
10.1124/jpet.103.051623
Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S and
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A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. Faseb J vol. 17, (9) 1544-+.
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Gavins FNE, Yona S, Kamal AM, Flower RJ and
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Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Blood vol. 101, (10) 4140-4147.
10.1182/blood-2002-11-3411
Perretti M, Paul-Clark MJ, Mancini L and Flower RJ (2003).
Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids. Digest Liver Dis vol. 35, S41-S48.
10.1016/S1590-8658(03)00051-3
Getting SJ, Christian HC, Lam CW, Gavins FNE, Flower RJ, Schioth HB and
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Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: Studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J Immunol vol. 170, (6) 3323-3330.
10.4049/jimmunol.170.6.3323
Hannon R, Croxtall JD, Getting SJ, Roviezzo F, Yona S, Paul-Clark MJ, Gavins FNE,
Perretti M, Morris JF, Buckingham JC and Flower RJ (2003).
Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. Faseb J vol. 17, (2) 253-255.
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PERRETTI M and Parente L (2003).
Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochemical Pharmacology vol. 65, (2) 153-159.
10.1016/s0006-2952(02)01422-32002

Getting SJ, Mahoney DJ, Cao T, Rugg MS, Fries E, Milner CM,
Perretti M and Day AJ (2002).
The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem vol. 277, (52) 51068-51076.
10.1074/jbc.M205121200
Fiorucci S, Antonelli E, Distrutti E, Del Soldato P, Flower RJ, Clark MJP, Morelli A,
Perretti M and Ignarro LJ (2002).
NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. P Natl Acad Sci Usa vol. 99, (24) 15770-15775.
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Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ,
Solito E and Serhan CN (2002).
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med vol. 8, (11) 1296-1302.
10.1038/nm786
Getting SJ, Christian HC, Flower RJ and
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Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum vol. 46, (10) 2765-2775.
10.1002/art.10526
Perretti M, Ingegnoli F, Wheller SK, Blades MC,
Solito E and Pitzalis C (2002).
Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. J Immunol vol. 169, (4) 2085-2092.
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Gibbs L, Carollo MG, Damazo AS, Oliani SM and
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Time-dependent expression of annexin 1 in a model of chronic granulomatous inflammation. Inflamm Res vol. 51, (6) 300-306.
10.1007/pl00000308
Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO,
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Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J Immunol vol. 168, (9) 4308-4317.
10.4049/jimmunol.168.9.4308
Calatayud S, Mitchell JA,
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Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery. Eur J Pharmacol vol. 440, (1) 71-77.
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Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS,
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Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice. Arthritis Rheum vol. 46, (3) 824-836.
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Malcangio M, Getting S, Grist J, Cunningham JR, Bradbury EJ, Issa PC, Lever IJ, Pezet S and
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A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. Faseb J vol. 16, (3) 730-+.
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Paul-Clark MJ, Mancini L, Del Soldato P, Flower RJ and
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Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis. P Natl Acad Sci Usa vol. 99, (3) 1677-1682.
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PERRETTI M, Damazo AS and Oliani SM (2002).
Annexin 1 localisation in tissue eosinophils as detected by electron microscopy. Mediators of Inflammation. vol. 11, 287-292.
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Ingegnoli F, Blades M, Manzo A, Wahid S,
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Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane. Reumatismo vol. 54, (2) 128-132.
10.4081/reumatismo.2002.128
Malcangio M, Getting SJ, Grist J, Cunningham JR, Bradbury EJ, Charbel Issa P, Lever IJ, Pezet S and
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A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. The Faseb Journal : Official Publication of The Federation of American Societies For Experimental Biology vol. 16, (7) 730-732.
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Stromal cell derived factor-1 (CXCL 12) induces monocyte migration into human synovium transplanted onto SCID mice. Arth Rheum vol. 46, 824-836.
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Carollo M, Hogaboam CM, Kunkel SL, Delaney S, Christie MI and
Perretti M (2001).
Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1alpha and MCP-1. Br J Pharmacol vol. 134, (6) 1166-1179.
10.1038/sj.bjp.0704371
Mabley JG, Jagtap P,
Perretti M, Getting SJ, Salzman AL, Virag L, Szabo E, Soriano FG, Liaudet L, Abdelkarim GE, Hasko G, Marton A, Southan GJ and Szabo C (2001).
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res vol. 50, (11) 561-569.
10.1007/PL00000234
(2001).
Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment. Eur J Pharmacol vol. 429, (1-3) 263-278.
10.1016/s0014-2999(01)01325-5
Getting SJ and
Perretti M (2001).
Arthritic diseases: Melanocortin type 3 receptor agonists as potential therapeutics. Current Opinion in Investigational Drugs vol. 2, (8) 1064-1069.

Damazo AS, de Lima WT,
Perretti M and Oliani SM (2001).
Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity. Eur J Pharmacol vol. 426, (1-2) 123-130.
10.1016/s0014-2999(01)01093-7
Henderson RB, Lim LHK, Tessier PA, Gavins FNE, Mathies M,
Perretti M and Hogg N (2001).
The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha 4 integrin in the inflammatory response of neutrophils. J Exp Med vol. 194, (2) 219-226.
10.1084/jem.194.2.219
Perretti M, Getting SJ,
Solito E, Murphy PM and Gao JL (2001).
Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol vol. 158, (6) 1969-1973.
10.1016/S0002-9440(10)64667-6
Diaz B, Barreto E, Cordeiro R,
Perretti M, Martins M and Silva P (2001).
Enhanced serum glucocorticoid levels mediate the reduction of serosal mast cell numbers in diabetic rats. Life Sci vol. 68, (26) 2925-2932.
10.1016/s0024-3205(01)01087-6
Solito E, de Coupade C, Canaider S, Goulding NJ and
Perretti M (2001).
Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. Brit J Pharmacol vol. 133, (2) 217-228.
10.1038/sj.bjp.0704054
Blades MC, Ingegnoli F, Manzo A, Wahid S, Haskard D, Panayi G,
Perretti M and Pitzalis C (2001).
Development of a new model to investigate lymphocyte migration into human peripheral lymph nodes (HPLN) transplanted into SCID mice. Rheumatology vol. 40, 66-66.

Oliani SM, Paul-Clark MJ, Christian HC, Flower RJ and
Perretti M (2001).
Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression. Am J Pathol vol. 158, (2) 603-615.
10.1016/S0002-9440(10)64002-3
Oliani SM, Lim LHK, Christian HC, Pell K, Das AM and
Perretti M (2001).
Morphological alteration of peritoneal mast cells and macrophages in the mouse peritoneal cavity during the early phases of an allergic inflammatory reaction. Cell Biol Int vol. 25, (8) 795-803.
10.1006/cbir.2001.0770
PERRETTI M, Obinger C, Furtmuller PG, Allegra M, Regelsberger G, Livrea MA, Tesoriere L and Turco-Leveri ML (2001).
Mechanism of Reaction of Melatonin with Human Myeloperoxidase. Biochem Biophys Res Commun. vol. 282, 380-386.
10.1006/bbrc.2001.4582
Allcock GH, Allegra M, Flower RJ and
Perretti M (2001).
Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1. Clin Exp Immunol vol. 123, (1) 62-67.
10.1046/j.1365-2249.2001.01370.x
Getting SJ, Allcock GH, Flower R and
Perretti M (2001).
Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. J Leukoc Biol vol. 69, (1) 98-104.
2000

Mancini L, Moradi-Bidhendi N, Brandi ML,
Perretti M and MacIntyre I (2000).
Modulation of the effects of osteoprotegerin (OPG) ligand in a human leukemic cell line by OPG and calcitonin. Biochem Bioph Res Co vol. 279, (2) 391-397.
10.1006/bbrc.2000.3953
McLean PG,
Perretti M and Ahluwalia A (2000).
Kinin B1 receptors and the cardiovascular system: Regulation of expression and function. Cardiovascular Research vol. 48, (2) 194-210.
10.1016/S0008-6363(00)00184-X
(2000).
Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment. Faseb J vol. 14, (13) 1867-1869.
10.1096/fj.99-0602fje
McLean PG, Ahluwalia A and
Perretti M (2000).
Association between kinin B1 receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules. Journal of Experimental Medicine vol. 192, (3) 367-380.
10.1084/jem.192.3.367
Getting SJ and
Perretti M (2000).
MC3-R as a novel target for antiinflammatory therapy. Drug News and Perspectives vol. 13, (1) 19-27.

McLean PG,
Perretti M and Ahluwalia A (2000).
Kinin B1 receptors as novel anti-inflammatory targets. Expert Opinion On Therapeutic Targets vol. 4, (2) 127-141.
10.1517/14728222.4.2.127
Canaider S,
Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ and
Perretti M (2000).
Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I). Life Sci vol. 66, (18) PL265-PL270.
10.1016/s0024-3205(00)00500-2
Lim LHK, Flower RJ,
Perretti M and Das AM (2000).
Glucocorticoid receptor activation reduces CD11b and CD49d levels on murine eosinophils: Characterization and functional relevance. American Journal of Respiratory Cell and Molecular Biology vol. 22, (6) 693-701.
10.1165/ajrcmb.22.6.3890
Paul-Clark M, Del Soldato P, Fiorucci S, Flower RJ and
Perretti M (2000).
21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties. British Journal of Pharmacology vol. 131, (7) 1345-1354.
10.1038/sj.bjp.0703704
Perretti M, Christian H, Wheller SK, Aiello I, Mugridge KG, Morris JF, Flower RJ and Goulding NJ (2000).
Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. Cell Biology International vol. 24, (3) 163-174.
10.1006/cbir.1999.0468
Oliani SM, Christian HC, Manston J, Flower RJ and
Perretti M (2000).
An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: Modulation by inflammation and dexamethasone. Laboratory Investigation vol. 80, (9) 1429-1438.
10.1038/labinvest.37801501999

McLean PG,
Perretti M and Ahluwalia A (1999).
Inducible expression of the kinin B1 receptor in the endotoxemic heart: Mechanisms of des-Arg9bradykinin-induced coronary vasodilation. British Journal of Pharmacology vol. 128, (2) 275-282.
10.1038/sj.bjp.0702743
Das AM, Ajuebor MN, Flower RJ,
Perretti M and McColl SR (1999).
Contrasting roles for RANTES and macrophage inflammatory protein-1α (MIP-1α) in a murine model of allergic peritonitis. Clinical and Experimental Immunology vol. 117, (2) 223-229.
10.1046/j.1365-2249.1999.00978.x
Getting SJ, Gibbs L, Clark AJL, Flower RJ and
Perretti M (1999).
POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. Journal of Immunology vol. 162, (12) 7446-7453.

Ruetten H, Thiemermann C and
Perretti M (1999).
Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-κB but not protein tyrosine kinase: Comparison to induction of iNOS. Mediators of Inflammation vol. 8, (2) 77-84.
10.1080/09629359990568
Ajuebor MN, Das AM, Virág L, Szabó C and
Perretti M (1999).
Regulation of macrophage inflammatory protein-1α expression and function by endogenous interleukin-10 in a model of acute inflammation. Biochemical and Biophysical Research Communications vol. 255, (2) 279-282.
10.1006/bbrc.1999.0196
Ajuebor MN, Das AM, Virág L, Flower RJ, Szabó C and
Perretti M (1999).
Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: Evidence for an inhibitory loop involving endogenous IL-10. Journal of Immunology vol. 162, (3) 1685-1691.

Tailor A, Tomlinson A, Salas A, Panés J, Granger DN, Flower RJ and
Perretti M (1999).
Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: Role of intercellular adhesion molecule 1 and KC. Gut vol. 45, (5) 705-712.
10.1136/gut.45.5.705
Perretti M, Wheller SK, Flower RJ, Wahid S and Pitzalis C (1999).
Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. Journal of Leukocyte Biology vol. 65, (5) 583-589.
10.1002/jlb.65.5.583
Euzger HS, Flower RJ, Goulding NJ and
Perretti M (1999).
Differential modulation of annexin I binding sites on monocytes and neutrophils. Mediators of Inflammation vol. 8, (1) 53-62.
10.1080/09629359990720
Minghetti L, Nicolini A, Polazzi E, Greco A,
Perretti M, Parente L and Levi G (1999).
Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocartin 1. British Journal of Pharmacology vol. 126, (6) 1307-1314.
10.1038/sj.bjp.07024231998

Ajuebor MN, Virág L, Flower RJ,
Perretti M and Szabó C (1998).
Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation. Immunology vol. 95, (4) 625-630.
10.1046/j.1365-2567.1998.00644.x
Lim LH,
Solito E, Russo-Marie F, Flower RJ and
Perretti M (1998).
Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A vol. 95, (24) 14535-14539.
10.1073/pnas.95.24.14535
Perretti M (1998).
Lipocortin 1 and chemokine modulation of granulocyte and monocyte accumulation in experimental inflammation. General Pharmacology vol. 31, (4) 545-552.
10.1016/S0306-3623(98)00039-1
Ajuebor MN, Gibbs L, Flower RJ, Das AM and
Perretti M (1998).
Investigation of the functional role played by the chemokine monocyte chemoattractant protein-1 in interleukin-1-induced murine peritonitis. British Journal of Pharmacology vol. 125, (2) 319-326.
10.1038/sj.bjp.0702071
(1998).
Impaired IL-1β-induced neutrophil accumulation in tachykinin NK1 receptor knockout mice. British Journal of Pharmacology vol. 124, (6) 1013-1015.
10.1038/sj.bjp.0701978
Pistritto G, Mancuso C, Tringali G,
Perretti M, Preziosi P and Navarra P (1998).
The relative contribution of constitutive and inducible cyclooxygenase activity to lipopolysaccharide-induced prostaglandin production by primary cultures of rat hypothalamic astrocytes. Neuroscience Letters vol. 246, (1) 45-48.
10.1016/S0304-3940(98)00226-2
Teixeira MM, Das AM, Miotla JM,
Perretti M and Hellewell PG (1998).
The role of lipocortin-1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse. British Journal of Pharmacology vol. 123, (3) 538-544.
10.1038/sj.bjp.0701625
Bryant CE,
Perretti M and Flower RJ (1998).
Suppression by dexamethasone of inducible nitric oxide synthase protein expression in vivo. A possible role for lipocortin 1. Biochemical Pharmacology vol. 55, (3) 279-285.
10.1016/S0006-2952(97)00462-0
Das AM, Flower RJ and
Perretti M (1998).
Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo. Journal of Leukocyte Biology vol. 64, (2) 156-162.
10.1002/jlb.64.2.156
Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A and
Perretti M (1998).
Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. Journal of Leukocyte Biology vol. 63, (1) 108-116.
10.1002/jlb.63.1.1081997

Das AM, Lim LHK, Flower RJ and
Perretti M (1997).
Dexamethasone reduces cell surface levels of CD11b on human eosinophils. Mediators of Inflammation vol. 6, (5-6) 363-367.
10.1080/09629359791505
Cuzzocrea S, Tailor A, Zingarelli B, Salzman AL, Flower RJ, Szabó C and
Perretti M (1997).
Lipocortin 1 Protects Against Splanchnic Artery Occlusion and Reperfusion Injury by Affecting Neutrophil Migration. Journal of Immunology vol. 159, (10) 5089-5097.

Szabó C, Lim LHK, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, Salzman AL and
Perretti M (1997).
Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. Journal of Experimental Medicine vol. 186, (7) 1041-1049.
10.1084/jem.186.7.1041
Das AM, Flower RJ and
Perretti M (1997).
Eotaxin-Induced Eosinophil Migration in the Peritoneal Cavity of Ovalbumin-Sensitized Mice: Mechanism of Action. Journal of Immunology vol. 159, (3) 1466-1473.

Wheller SK and
Perretti M (1997).
Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines. European Journal of Pharmacology vol. 331, (1) 65-71.
10.1016/S0014-2999(97)01015-7
Ferreira SH, Cunha FQ, Lorenzetti BB, Michelin MA,
Perretti M, Flower RJ and Poole S (1997).
Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. British Journal of Pharmacology vol. 121, (5) 883-888.
10.1038/sj.bjp.0701211
Tailor A, Das AM, Getting SJ, Flower RJ and
Perretti M (1997).
Subacute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes. Biochemical and Biophysical Research Communications vol. 231, (3) 675-678.
10.1006/bbrc.1997.6168
Tailor A, Flower RJ and
Perretti M (1997).
Dexamethasone inhibits leukocyte emigration in rat mesenteric post- capillary venules: An intravital microscopy study. Journal of Leukocyte Biology vol. 62, (3) 301-308.
10.1002/jlb.62.3.301
Getting SJ, Flower RJ, Parente L, De Medicis R, Lussier A, Woliztky BA, Martins MA and
Perretti M (1997).
Molecular determinants of monosodium urate crystal-induced murine peritonitis: A role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Journal of Pharmacology and Experimental Therapeutics vol. 283, (1) 123-130.

Das AM, Flower RJ, Hellewell PG, Teixeira MM and
Perretti M (1997).
A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment. British Journal of Pharmacology vol. 121, (1) 97-104.
10.1038/sj.bjp.0701122
Getting SJ, Flower RJ and
Perretti M (1997).
Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. British Journal of Pharmacology vol. 120, (6) 1075-1082.
10.1038/sj.bjp.07010291996
Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon R and Flower RJ (1996).
Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nature Medicine vol. 2, (11) 1259-1262.
10.1038/nm1196-1259
Perretti M, Wheller SK, Harris JG and Flower RJ (1996).
Modulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-1β and dexamethasone. Biochemical and Biophysical Research Communications vol. 223, (1) 112-117.
10.1006/bbrc.1996.0854
Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA and
Perretti M (1996).
Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). Biochemical and Biophysical Research Communications vol. 221, (3) 692-696.
10.1006/bbrc.1996.0658
Malcangio M, Bowery NG, Flower RJ and
Perretti M (1996).
Effect of interleukin-1β on the release of substance P from rat isolated spinal cord. European Journal of Pharmacology vol. 299, (1-3) 113-118.
10.1016/0014-2999(95)00845-4
Perretti M, Ahluwalia A, Harris JG, Harris HJ, Wheller SK and Flower RJ (1996).
Acute inflammatory response in the mouse: Exacerbation by immunoneutralization of lipocortin 1. British Journal of Pharmacology vol. 117, (6) 1145-1154.
10.1111/j.1476-5381.1996.tb16709.x
Perretti M and Flower RJ (1996).
Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: Modulation by glucocorticoids and inflammation. British Journal of Pharmacology vol. 118, (3) 605-610.
10.1111/j.1476-5381.1996.tb15444.x
Ahluwalia A and
Perretti M (1996).
Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1β in vivo in the mouse. Journal of Immunology vol. 156, (1) 269-274.

Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA and
Perretti M (1996).
Erratum: Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC) (Biochemical and Biophysical Research Communications (1996) 221 3 (692-696)). Biochemical and Biophysical Research Communications vol. 224, (3) 878-879.
10.1006/bbrc.1996.11171995
Perretti M, Wheller SK, Choudhury Q, Croxtall JD and Flower RJ (1995).
Selective inhibition of neutrophil function by a peptide derived from lipocortin 1 N-terminus. Biochemical Pharmacology vol. 50, (7) 1037-1042.
10.1016/0006-2952(95)00238-U
Harris JG, Flower RJ and
Perretti M (1995).
Endogenous corticosteroids mediate the neutrophilia caused by platelet-activating factor in the mouse. European Journal of Pharmacology vol. 283, (1-3) 9-18.
10.1016/0014-2999(95)00274-O
Klemm P, Harris HJ and
Perretti M (1995).
Effect of rolipram in a murine model of acute inflammation: comparison with the corticoid dexamethasone. European Journal of Pharmacology vol. 281, (1) 69-74.
10.1016/0014-2999(95)00232-A
Palmi M, Frosini M, Sgaragli GP, Becherucci C,
Perretti M and Parente L (1995).
Inhibition of interleukin-1β-induced pyresis in the rabbit by peptide 204-212 of lipocortin 5. European Journal of Pharmacology vol. 281, (1) 97-99.
10.1016/0014-2999(95)00304-4
Harris JG, Flower RJ and
Perretti M (1995).
Alteration of neutrophil trafficking by a lipocortin 1 N-terminus peptide. European Journal of Pharmacology vol. 279, (2-3) 149-157.
10.1016/0014-2999(95)00145-B
Wu CC, Croxtall JD,
Perretti M, Bryant CE, Thiemermann C, Flower RJ and Vane JR (1995).
Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proceedings of The National Academy of Sciences of The United States of America vol. 92, (8) 3473-3477.
10.1073/pnas.92.8.3473
Mancuso F, Flower RJ and
Perretti M (1995).
Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule: Involvement of endogenous lipocortin 1. Journal of Immunology vol. 155, (1) 377-386.
Perretti M, Szabó C and Thiemermann C (1995).
Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse. British Journal of Pharmacology vol. 116, (4) 2251-2257.
10.1111/j.1476-5381.1995.tb15061.x
Mugridge KG,
Perretti M, Ghiara P, Galeotti CL, Melli M and Parente L (1995).
Gastric antisecretory and anti-ulcer actions of IL-1 in rat involve different IL-1 receptor types. American Journal of Physiology - Gastrointestinal and Liver Physiology vol. 269, (5 32-5)
10.1152/ajpgi.1995.269.5.g7631994

Ahluwalia A and
Perretti M (1994).
Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. European Journal of Pharmacology vol. 264, (3) 407-415.
10.1016/0014-2999(94)00503-6
Szabó C, Thiemermann C, Wu CC,
Perretti M and Vane JR (1994).
Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proceedings of The National Academy of Sciences of The United States of America vol. 91, (1) 271-275.
10.1073/pnas.91.1.271
Perretti M, Harris JG and Flower RJ (1994).
A role for endogenous histamine in interleukin‐8‐induced neutrophil infiltration into mouse air‐pouch: investigation of the modulatory action of systemic and local dexamethasone. British Journal of Pharmacology vol. 112, (3) 801-808.
10.1111/j.1476-5381.1994.tb13150.x
Ahluwalia A and
Perretti M (1994).
Anti-inflammatory effect of prostanoids in mouse and rat skin: Evidence for a role of EP3-receptors. Journal of Pharmacology and Experimental Therapeutics vol. 268, (3) 1526-1531.
1993
Perretti M, Ahluwalia A, Flowers RJ and Manzini S (1993).
Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: Involvement of NK-1 receptors. Immunology vol. 80, (1) 73-77.
Perretti M, Ahluwalia A, Harris JG, Goulding NJ and Flower RJ (1993).
Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil- dependent edema in the mouse: A qualitative comparison with an anti-CD11b monoclonal antibody. Journal of Immunology vol. 151, (8) 4306-4314.
Perretti M, Duncan GS, Flower RJ and Peers SH (1993).
Serum corticosterone, interleukin‐1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains. British Journal of Pharmacology vol. 110, (2) 868-874.
10.1111/j.1476-5381.1993.tb13893.x
Perretti M, Flower RJ and Goulding NJ (1993).
The ability of murine leukocytes to bind lipocortin 1 is lost during acute inflammation. Biochemical and Biophysical Research Communications vol. 192, (2) 345-350.
10.1006/bbrc.1993.1421
Cirino G, Cicala C, Sorrentino L, Ciliberto G, Arpaia G,
Perretti M and Flower RJ (1993).
Anti‐inflammatory actions of an N‐terminal peptide from human lipocortin 1. British Journal of Pharmacology vol. 108, (3) 573-574.
10.1111/j.1476-5381.1993.tb12843.x
Perretti M and Flower RJ (1993).
Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1. Journal of Immunology vol. 150, (3) 992-999.

Thiemermann C, Wu C, Szabó C,
Perretti M and Vane JR (1993).
Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. British Journal of Pharmacology vol. 110, (1) 177-182.
10.1111/j.1476-5381.1993.tb13789.x
Da Silva JAP, Peers SH,
Perretti M and Willoughby DA (1993).
Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1. Journal of Endocrinology vol. 136, (3) 389-397.
10.1677/joe.0.1360389
Becherucci C, Parente L,
Perretti M and Mugridge KG (1993).
Inhibition of smooth muscle contraction and platelet aggregation by peptide 204-212 of lipocortin 5: an attempt to define some structure requirements. Mediators of Inflammation vol. 2, (2) 103-107.
10.1155/S0962935193000146
Becherucci C,
Perretti M,
Solito E, Galeotti CL and Parente L (1993).
Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5. Mediators Inflamm vol. 2, (2) 109-113.
10.1155/S09629351930001581992

Becherucci C,
Perretti M, Nencioni L, Silvestri S and Parente L (1992).
Anti-inflammatory effect of tuftsin and its retro-inverso analogue in rat adjuvant arthritis. Agents and Actions vol. 36, (1 Supplement)
10.1007/BF01991043
Douglas GJ, Flower RJ, Parente L and
Perretti M (1992).
Peptide 204-212 of lipocortin 5 inhibits the generation of a prostacyclin-like factor from rat aorta preparations in vitro. Prostaglandins vol. 44, (5) 381-388.
10.1016/0090-6980(92)90134-F
Parente L,
Perretti M, Wallace JL and Mugridge KG (1992).
Mechanism of the protective action of interleukin-1 in the experimental gastric damage in the rat. Pharmacological Research vol. 26, (SUPPL. 2) 28-29.
10.1016/1043-6618(92)90584-X
Perretti M, Mugridge KG, Wallace JL and Parente L (1992).
Reduction of aspirin-induced gastric damage in rats by interleukin-1β: Possible involvement of endogenous corticosteroids. Journal of Pharmacology and Experimental Therapeutics vol. 261, (3) 1238-1247.
Perretti M,
Solito E and Parente L (1992).
Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice. Agents Actions vol. 35, (1-2) 71-78.
10.1007/BF019909541991

Verdini AS, Pinori M, Silvestri S, Becherucci C, Longobardi MG, Parente L, Peppoloni S,
Perretti M, Pileri P, Viscomi GC and Nencioni L (1991).
Immunostimulation by a Partially Modified retro -in verso -Tuftsin Analogue Containing Thr1ψ[NHCO](R,S)Lys2 Modification. Journal of Medicinal Chemistry vol. 34, (12) 3372-3379.
10.1021/jm00116a005
Mugridge KG,
Perretti M, Ghiara P and Parente L (1991).
α-melanocyte-stimulating hormone reduces interleukin-lβ effects on rat stomach preparations possibly through interference with a type I receptor. European Journal of Pharmacology vol. 197, (2-3) 151-155.
10.1016/0014-2999(91)90514-Q
Mugridge KG,
Perretti M and Parente L (1991).
5-Lipoxygenase activation may facilitate an interleukin-1 transduction signal. Advances in Prostaglandin, Thromboxane, and Leukotriene Research vol. 21 B, 517-520.
Perretti M, Mugridge KG, Becherucci C and Parente L (1991).
Evidence that interleukin-1 and lipoxygenase metabolites mediate the lethal effect of complete Freund's adjuvant in adrenalectomized rats. Lymphokine and Cytokine Research vol. 10, (4) 239-243.

Mugridge KG,
Perretti M, Becherucci C and Parente L (1991).
Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: Implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase. Journal of Pharmacology and Experimental Therapeutics vol. 256, (1) 29-37.

Piaz VD, Ciciani G, Turco G, Giovannoni MP, Miceli M, Pirisino R and
Perretti M (1991).
5‐Acyl‐6‐Aryl‐4‐Nitro‐3(2HH)Pyridazinones and related 4‐amino compounds: Synthesis and pharmacological evaluation. Journal of Pharmaceutical Sciences vol. 80, (4) 341-348.
10.1002/jps.26008004121990
Perretti M, Mugridge KG, Becherucci C, Silvestri S and Parente L (1990).
Antiulcer property of human recombinant interleukin-1β. Pharmacological Research vol. 22,
10.1016/1043-6618(90)90427-F
Perretti M, Nuti S and Parente L (1990).
Investigation of rat mast cell degranulation using flow cytometry. Journal of Pharmacological Methods vol. 23, (3) 187-194.
10.1016/0160-5402(90)90062-P
Parente L, Becherucci C,
Perretti M,
Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M and Sanso M (1990).
Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids? Prog Clin Biol Res vol. 349, 55-68.
1989

Becherucci C, Donati D,
Perretti M and Parente L (1989).
The release of interleukin-1-like activity by macrophages in two models of immunological inflammation in the rat. Agents and Actions vol. 28, (3-4) 243-247.
10.1007/BF01967410
Perretti M, Becherucci C, Scapigliati G and Parente L (1989).
The effect of adrenalectomy on interleukin-1 release in vitro and in vivo. British Journal of Pharmacology vol. 98, (4) 1137-1142.
10.1111/j.1476-5381.1989.tb12657.x1988

Ignesti G, Buffoni F,
Perretti M and Cintelli A (1988).
Induction and quail liver diamine oxidase (histaminase). Part II: Different responses to the inducers. Agents and Actions vol. 25, (1-2) 43-47.
10.1007/BF01969092
Ignesti G,
Perretti M and Buffoni F (1988).
Induction and quail liver diamine oxidase (histaminase). Part I: Interference of spermidine synthase on the diamine oxidase activity assay using putrescine as substrate. Agents and Actions vol. 25, (1-2) 37-42.
10.1007/BF01969091
Perretti M, Becherucci C and Parente L (1988).
Interleukin-1 release by macrophages from adrenalectomized (ADX) and shamoperated (SHO) rats. Pharmacological Research Communications vol. 20, (SUPPL. 2)
10.1016/S0031-6989(88)80429-6
Becherucci C, Donati D,
Perretti M and Parente L (1988).
Interleukin-1 release by rat macrophages in experimental immunological inflammation. Pharmacological Research Communications vol. 20, (SUPPL. 2)
10.1016/S0031-6989(88)80159-01986

Ignesti G,
Perretti M and Buffoni F (1986).
Diamine oxidase activity in Japanese quail liver induced with Aroclor 1254. Agents and Actions vol. 18, (1-2) 41-43.
10.1007/BF019879771981