Prof Mauro Perretti
BSc, PhDProfessor of Immunopharmacology
William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Therapeutic Innovation, Inflammation, Arthritis, Joint disease, Fibrosis
Interests
Interest in co-culture settings that mimic the joint: macrophages, fibroblasts and chondrocytes. Keen to collaborate on bone cells.Publications
Publications of specific relevance to Predictive in vitro Models
2024
Walker ME, De Matteis R, Perretti M and Dalli J (2024). Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease. Springer Nature Nature Communications vol. 15, (1) 10.1038/s41467-024-44868-1
Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S and Panigrahy D (2024). Addendum: Resolvins suppress tumor growth and enhance cancer therapy. Rockefeller University Press Journal of Experimental Medicine vol. 221, (3) 10.1084/jem.2017068101232024a
2023
Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J, Gamble J, Vadas M, Annex BH, Messe SR, Perretti M, André H, Ferrara N, Hla T, Nourshargh S and Simons M (2023). Report from the 2023 workshop on endothelial permeability, edema and inflammation. Springer Nature Nature Cardiovascular Research vol. 2, (12) 1120-1124. 10.1038/s44161-023-00385-w
Chen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TE and Perretti M (2023). The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation. Elsevier Pharmacological Research vol. 198, 10.1016/j.phrs.2023.107005
Granell R, Curtin JA, Haider S, Kitaba NT, Mathie SA, Gregory LG, Yates LL, Tutino M, Hankinson J, Perretti M, Vonk JM, Arshad HS, Cullinan P, Fontanella S, Roberts GC, Koppelman GH, Simpson A, Turner SW, Murray CS, Lloyd CM, Holloway JW and Custovic A (2023). A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing. Elife Elife vol. 12, 10.7554/elife.84315
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2023). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society For Clinical Investigation Jci Insight vol. 8, (3) 10.1172/jci.insight.168728
Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C and Perretti M (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. Karger Publishers Journal of Innate Immunity vol. 15, (1) 548-561. 10.1159/000530284
2022
Perretti M and Subramanian M (2022). Resolution pharmacology − A fresh approach to the clinical management of human inflammatory diseases. Elsevier Seminars in Immunology vol. 65, 10.1016/j.smim.2022.101669
Ward EJ, Bert S, Fanti S, Malone KM, Maughan RT, Gkantsinikoudi C, Prin F, Volpato LK, Piovezan AP, Graham GJ, Dufton NP, Perretti M, Marelli-Berg FM and Nadkarni S (2022). Placental Inflammation Leads to Abnormal Embryonic Heart Development. Wolters Kluwer Circulation vol. 147, (12) 956-972. 10.1161/circulationaha.122.061934
Garrido-Mesa J, Thomas BL, Dodd J, Spana C, Perretti M and Montero-Melendez T (2022). Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177. Frontiers Frontiers in Immunology vol. 13, 10.3389/fimmu.2022.1078678
Bert S, Nadkarni S and Perretti M (2022). Neutrophil‐T cell crosstalk and the control of the host inflammatory response. Wiley Immunological Reviews vol. 314, (1) 36-49. 10.1111/imr.13162
Perretti M and Dalli J (2022). Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation. Annual Reviews The Annual Review of Pharmacology and Toxicology vol. 63, (1) 449-469. 10.1146/annurev-pharmtox-051821-042743
Oggero S, Cecconello C, Silva R, Zeboudj L, Sideris-Lampretsas G, Perretti M and Malcangio M (2022). Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain. Elsevier Brain Behavior and Immunity vol. 106, 289-306. 10.1016/j.bbi.2022.09.008
de Araújo S, de Melo Costa VR, Santos FM, de Sousa CDF, Moreira TP, Gonçalves MR, Félix FB, Queiroz-Junior CM, Campolina-Silva GH, Nogueira ML, Sugimoto MA, Bonilha CS, Perretti M, Souza DG, Costa VV and Teixeira MM (2022). Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection. Mdpi Cells vol. 11, (17) 10.3390/cells11172717
Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M and Ritchie RH (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. Wiley British Journal of Pharmacology vol. 179, (19) 4617-4639. 10.1111/bph.15919
Oggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P, Norling LV, Perretti M and Gupta A (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Wolters Kluwer Journal of Hypertension vol. 40, (8) 1522-1529. 10.1097/hjh.0000000000003178
Margraf A and Perretti M (2022). Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes. Mdpi Cells vol. 11, (11) 10.3390/cells11111824
Gadipudi LL, Ramavath NN, Provera A, Reutelingsperger C, Albano E, Perretti M and Sutti S (2022). Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis. Portland Press Clinical Science vol. 136, (9) 643-656. 10.1042/cs20211122
Costa VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T, Rodrigues GOL, Bambirra JL, Passos IB, Lopes CEM, Moreira TP, Bonjour K, Melo RC, Oliveira MA, Andrade MVM, Sousa LP, Souza DG, da Costa Santiago H, Perretti M and Teixeira MM (2022). Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease. Elife Elife vol. 11, 10.7554/elife.73853
Hamilton A, Rizzo R, Brod S, Ono M, Perretti M, Cooper D and D'Acquisto F (2022). The immunomodulatory effects of social isolation in mice are linked to temperature control. Elsevier Brain Behavior and Immunity vol. 102, 179-194. 10.1016/j.bbi.2022.02.022
Ferreira TPT, Guimarães FV, Sá YAPJ, da Silva Ribeiro NB, de Arantes ACS, de Frias Carvalho V, Sousa LP, Perretti M, Martins MA and Rodrigues e Silva PM (2022). Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. Mdpi Cells vol. 11, (5) 10.3390/cells11050759
2021
de Paula-Silva M, da Rocha GHO, Broering MF, Queiroz ML, Sandri S, Loiola RA, Oliani SM, Vieira A, Perretti M and Farsky SHP (2021). Formyl Peptide Receptors and Annexin A1: Complementary Mechanisms to Infliximab in Murine Experimental Colitis and Crohn’s Disease. Frontiers Frontiers in Immunology vol. 12, 10.3389/fimmu.2021.714138
Chen J, Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 118, (38) 10.1073/pnas.2020385118
Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O and Chapman TM (2021). Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. Elsevier European Journal of Medicinal Chemistry vol. 226, 10.1016/j.ejmech.2021.113805
das Dores Pereira R, Rabelo RAN, Leite PG, Cramer A, Botelho AFM, Cruz JS, Régis WCB, Perretti M, Teixeira MM and Machado FS (2021). Role of formyl peptide receptor 2 (FPR2) in modulating immune response and heart inflammation in an experimental model of acute and chronic Chagas disease. Elsevier Cellular Immunology vol. 369, 10.1016/j.cellimm.2021.104427
Man F, Nadkarni S, Kanabar V, E-Lacerda RR, Gomes Ferreira S, Federici Canova D, Perretti M, Page CP and Riffo-Vasquez Y (2021). A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation. American Physiological Society American Journal of Physiology - Lung Cellular and Molecular Physiology vol. 321, (5) l803-l813. 10.1152/ajplung.00155.2021
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin M-B, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E and Nourshargh S (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Elsevier Immunity vol. 54, (9) 1989-2004.e9. 10.1016/j.immuni.2021.07.012
Coenen DM, Heinzmann ACA, Oggero S, Albers HJ, Nagy M, Hagué P, Kuijpers MJE, Vanderwinden J-M, van der Meer AD, Perretti M, Koenen RR and Cosemans JMEM (2021). Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. Mdpi Cells vol. 10, (8) 10.3390/cells10081998
Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K, Kocher HM, Ricketts W, Thomas G, Perretti M, Alusi G, Pfeffer P and Dalli J (2021). Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19. Circulation Research E54-E71. 10.1161/CIRCRESAHA.121.319142
Pessolano E, Belvedere R, Novizio N, Filippelli A, Perretti M, Whiteford J and Petrella A (2021). Mesoglycan connects Syndecan‐4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro. Wiley The Febs Journal vol. 288, (22) 6428-6446. 10.1111/febs.16043
de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C and Guiry PJ (2021). Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms). American Chemical Society (Acs) Journal of Medicinal Chemistry vol. 64, (13) 9193-9216. 10.1021/acs.jmedchem.1c00403
Marques RM, Gonzalez-Nunez M, Walker ME, Gomez EA, Colas RA, Montero-Melendez T, Perretti M and Dalli J (2021). Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions. Springer Nature Cell Death & Differentiation vol. 28, (11) 3140-3160. 10.1038/s41418-021-00807-x
Thomas B, Eldridge S, Nosrati B, Alvarez M, THORUP A-S, Nalesso G, Caxaria S, Barawi A, Nicholson J, Perretti M, Gaston-Massuet C, Pitzalis C, Maloney A, Moore A, Jupp R and Dell'Accio F (2021). WNT3A-loaded exosomes enable cartilage repair. Co-Action Publishing Journal of Extracellular Vesicles 10.1002/jev2.12088
Ito T, Shintani Y, Fields L, Shiraishi M, Podaru M, Kainuma S, Yamashita K, Kobayashi K, Perretti M, Lewis-McDougall F and Suzuki K (2021). Cell barrier function of resident peritoneal macrophages in post-operative adhesions. Springer Nature Nature Communications vol. 12, (1) 10.1038/s41467-021-22536-y
Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D, Montero‐Melendez T, Cooper D, Burgoyne T, Belton O, Norling LV, Brennan EP, Godson C and Perretti M (2021). Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. Wiley Journal of Extracellular Vesicles vol. 10, (6) 10.1002/jev2.12084
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and Perretti M (2021). Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis. Wiley The Faseb Journal vol. 35, (5) 10.1096/fj.202001801r
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C (2021). Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”. Hindawi Mediators of Inflammation vol. 2021, 10.1155/2021/9861434
Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O and Chapman TM (2021). Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. Elsevier European Journal of Medicinal Chemistry vol. 214, 10.1016/j.ejmech.2021.113194
Davan-Wetton CSA, Pessolano E, Perretti M and Montero-Melendez T (2021). Senescence under appraisal: hopes and challenges revisited. Springer Nature Cellular and Molecular Life Sciences vol. 78, (7) 3333-3354. 10.1007/s00018-020-03746-x
2020
Novizio N, Belvedere R, Pessolano E, Tosco A, Porta A, Perretti M, Campiglia P, Filippelli A and Petrella A (2020). Annexin A1 Released in Extracellular Vesicles by Pancreatic Cancer Cells Activates Components of the Tumor Microenvironment, through Interaction with the Formyl-Peptide Receptors. Mdpi Cells vol. 9, (12) 10.3390/cells9122719
Fitzsimons S, Oggero S, Bruen R, McCarthy C, Strowitzki MJ, Mahon NG, Ryan N, Brennan EP, Barry M, Perretti M and Belton O (2020). microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression. Frontiers Frontiers in Immunology vol. 11, 10.3389/fimmu.2020.576516
Belvedere R, Morretta E, Pessolano E, Novizio N, Tosco A, Porta A, Whiteford J, Perretti M, Filippelli A, Monti MC and Petrella A (2020). Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2. Wiley Journal of Cellular Physiology vol. 236, (7) 4926-4943. 10.1002/jcp.30207
Perretti M (2020). Switching on resolution to treat RA moves closer to reality. Springer Nature Nature Reviews Rheumatology vol. 17, (2) 73-74. 10.1038/s41584-020-00549-z
Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M and Ioan-Facsinay A (2020). Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid. The American Association of Immunologists The Journal of Immunology vol. 205, (10) 2840-2849. 10.4049/jimmunol.1801653
Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M and Norling LV (2020). The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. Frontiers Media Frontiers in Immunology vol. 11, 573019-573019. 10.3389/fimmu.2020.573019
Belvedere R, Novizio N, Pessolano E, Tosco A, Eletto D, Porta A, Campiglia P, Perretti M, Filippelli A and Petrella A (2020). Heparan sulfate binds the extracellular Annexin A1 and blocks its effects on pancreatic cancer cells. Elsevier Biochemical Pharmacology vol. 182, 10.1016/j.bcp.2020.114252
Perretti M and Godson C (2020). Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology. Wiley British Journal of Pharmacology vol. 177, (20) 4595-4600. 10.1111/bph.15212
Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T, Werz O, Chiurchiù V, Azzi A, Dubourdeau M, Gupta SS, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, Tripathi A, Cesnulevicius K, Lescheid D, Schultz M, Särndahl E, Repsilber D, Kruse R, Sala A, Haeggström JZ, Levy BD, Filep JG and Wolkenhauer O (2020). The Atlas of Inflammation Resolution (AIR). Elsevier Molecular Aspects of Medicine 10.1016/j.mam.2020.100893
Hebeda CB, Sandri S, Benis CM, de Paula-Silva M, Loiola RA, Reutelingsperger C, Perretti M and Farsky SHP (2020). Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst. Mdpi Cells vol. 9, (5) 10.3390/cells9051188
Allen BL, Montague-Cardoso K, Simeoli R, Colas RA, Oggero S, Vilar B, McNaughton PA, Dalli J, Perretti M, Sher E and Malcangio M (2020). Imbalance of proresolving lipid mediators in
persistent allodynia dissociated from signs of
clinical arthritis. Lippincott, Williams & Wilkins Pain 10.1097/j.pain.0000000000001908
Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C and Bombardieri M (2020). H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones. The American Association of Immunologists The Journal of Immunology vol. 204, (9) 10.4049/jimmunol.1901457
Norling LV and Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 117, (17) 9148-9150. 10.1073/pnas.2004241117
Piras G, Rattazzi L, Paschalidis N, Oggero S, Berti G, Ono M, Bellia F, D'Addario C, Dell'Osso B, Pariante CM, Perretti M and D'Acquisto F (2020). Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Elsevier Brain Behavior and Immunity vol. 87, 689-702. 10.1016/j.bbi.2020.02.015
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media Frontiers in Immunology vol. 11, 10.3389/fimmu.2020.00010
Montero Melendez T, Nagano A, Chelala C, Filer A, Buckley CD and Perretti M (2020). Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis. Nature Research (Part of Springer Nature) Nature Communications vol. 11, (1) 10.1038/s41467-020-14421-x
McArthur S, Gobbetti T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP, Perretti M and Mounier R (2020). Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation. American Society For Clinical Investigation Journal of Clinical Investigation 10.1101/375709
2019
Belvedere R, Pessolano E, Porta A, Tosco A, Parente L, Petrella F, Perretti M and Petrella A (2019). Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound healing. Elsevier European Journal of Pharmacology vol. 869, 10.1016/j.ejphar.2019.172894
Machado MG, Tavares LP, Souza GVS, Queiroz‐Junior CM, Ascenção FR, Lopes ME, Garcia CC, Menezes GB, Perretti M, Russo RC, Teixeira MM and Sousa LP (2019). The Annexin A1/FPR2 pathway controls the inflammatory response and bacterial dissemination in experimental pneumococcal pneumonia. Wiley The Faseb Journal vol. 34, (2) 2749-2764. 10.1096/fj.201902172r
Sinniah A, Yazid S, Bena S, Oliani SM, Perretti M and Flower RJ (2019). Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions. Frontiers Frontiers in Pharmacology vol. 10, 10.3389/fphar.2019.01313
Barbosa CMV, Fock RA, Hastreiter AA, Reutelingsperger C, Perretti M, Paredes-Gamero EJ and Farsky SHP (2019). Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway. Springer Nature Cell Death Discovery vol. 5, (1) 10.1038/s41420-019-0215-1
Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Petrella F, Porta A, Tosco A, Parente L, Perretti M and Petrella A (2019). Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs. Mdpi Cells vol. 8, (7) 10.3390/cells8070753
Vago JP, Sugimoto MA, Lima KM, Negreiros-Lima GL, Baik N, Teixeira MM, Perretti M, Parmer RJ, Miles LA and Sousa LP (2019). Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes. Frontiers Frontiers in Immunology vol. 10, 10.3389/fimmu.2019.01458
Senchenkova EY, Ansari J, Becker F, Vital SA, Al-Yafeai Z, Sparkenbaugh EM, Pawlinski R, Stokes KY, Carroll JL, Dragoi A-M, Qin CX, Ritchie RH, Sun H, Cuellar-Saenz HH, Rubinstein MR, Han YW, Orr AW, Perretti M, Granger DN and Gavins FNE (2019). Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation. Wolters Kluwer Circulation vol. 140, (4) 319-335. 10.1161/circulationaha.118.039345
Salamah MF, Ravishankar D, Vaiyapuri R, Moraes LA, Patel K, Perretti M, Gibbins JM and Vaiyapuri S (2019). The formyl peptide fMLF primes platelet activation and augments thrombus formation. Elsevier Journal of Thrombosis and Haemostasis vol. 17, (7) 1120-1133. 10.1111/jth.14466
Bizzarro V, Belvedere R, Pessolano E, Parente L, Petrella F, Perretti M and Petrella A (2019). Mesoglycan induces keratinocyte activation by triggering syndecan‐4 pathway and the formation of the annexin A1/S100A11 complex. Wiley Journal of Cellular Physiology vol. 234, (11) 20174-20192. 10.1002/jcp.28618
Nadkarni S, Lashin H, Hollywood J, Dasgupta B, Mason JC and Perretti M (2019). Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: potential involvement of immune cell cross talk. Portland Press Clinical Science vol. 133, (7) 10.1042/cs20180415
Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P, Reutelingsperger CP, Naccache J-M, Bonnotte B, Karras A, Puéchal X, Guillevin L, Terrier B, Frachet P, Perretti M, Mouthon L and Witko-Sarsat V (2019). Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance. Elsevier Kidney International vol. 96, (2) 397-408. 10.1016/j.kint.2019.02.017
Sugimoto MA, Vago JP, Perretti M and Teixeira MM (2019). Mediators of the Resolution of the Inflammatory Response. Elsevier Trends in Immunology vol. 40, (3) 212-227. 10.1016/j.it.2019.01.007
Di Paola R, Fusco R, Gugliandolo E, D'Amico R, Cordaro M, Impellizzeri D, Perretti M and Cuzzocrea S (2019). Formyl peptide receptor 1 signalling promotes experimental colitis in mice. Elsevier Pharmacological Research vol. 141, 591-601. 10.1016/j.phrs.2019.01.041
VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C, PERRETTI M and NOURSHARGH S (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. Wiley Journal of Pathology vol. 248, (1) 88-102. 10.1002/path.5234
2018
Pessolano E, Belvedere R, Bizzarro V, Franco P, De Marco I, Porta A, Tosco A, Parente L, Perretti M and Petrella A (2018). Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System. Mdpi International Journal of Molecular Sciences vol. 19, (12) 10.3390/ijms19123878
Petri MH, Thul S, Andonova T, Lindquist-Liljeqvist M, Jin H, Skenteris N-T, Arnardottir H, Maegdefessel L, Caidahl K, Perretti M, Roy J and Bäck M (2018). Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms. Elsevier Jacc Basic to Translational Science vol. 3, (6) 719-727. 10.1016/j.jacbts.2018.08.005
Salamah MF, Ravishankar D, Kodji X, Moraes LA, Williams HF, Vallance TM, Albadawi DA, Vaiyapuri R, Watson K, Gibbins JM, Brain SD, Perretti M and Vaiyapuri S (2018). The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation. American Society of Hematology Blood Advances vol. 2, (21) 2973-2985. 10.1182/bloodadvances.2018021758
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C and Guiry PJ (2018). Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). Elsevier European Journal of Medicinal Chemistry vol. 162, 80-108. 10.1016/j.ejmech.2018.10.049
Frigerio F, Pasqualini G, Craparotta I, Marchini S, van Vliet EA, Foerch P, Vandenplas C, Leclercq K, Aronica E, Porcu L, Pistorius K, Colas RA, Hansen TV, Perretti M, Kaminski RM, Dalli J and Vezzani A (2018). n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain vol. 141, (11) 3130-3143. 10.1093/brain/awy247
Thomas BL and Perretti M (2018). Neutrophil wrap. Springer Nature Nature Nanotechnology vol. 13, (12) 1098-1099. 10.1038/s41565-018-0260-6
MCARTHUR S, GOBBETTI T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa J, Reutelingsperger C, PERRETTI M and Mounier R (2018). Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation. Biorxiv vol. 375709, (375709) 1-1. 10.1101/375709
Patruno S, Garrido-Mesa J, Romano M, PERRETTI M and MONTERO MELENDEZ T (2018). Ligand bias and its association with pro-resolving actions of melanocortin drugs. Frontiers Media Frontiers in Pharmacology vol. 9, (919) 10.3389/fphar.2018.00919
PITZALIS C, CORSIERO E, JAGEMANN L, PERRETTI M and BOMBARDIERI M (2018). Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints. American Association of Immunologists Journal of Immunology 10.4049/jimmunol.1800346
Qin CX, Finlayson SB, Al-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF, Perretti M, Murphy AJ, Du X-J, Gao X-M and Ritchie RH (2018). Author Correction: Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo. Springer Nature Scientific Reports vol. 8, (1) 10.1038/s41598-018-24994-9
Lashin HMS, Nadkarni S, Oggero S, Jones HR, Knight JC, Hinds CJ and Perretti M (2018). Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis. Shock vol. 49, (4) 393-401. 10.1097/SHK.0000000000000989
Fusco R, Di Paola R, Gugliandolo E, D'Amico R, Perretti M and Cuzzocrea S (2018). Formyl peptide receptor 1 signalling promotes experimental colitis in mice. Wiley The Faseb Journal vol. 32, (S1) 832.10-832.10. 10.1096/fasebj.2018.32.1_supplement.832.10
Hebeda CB, Machado ID, Reif‐Silva I, Moreli JB, Oliani SM, Nadkarni S, Perretti M, Bevilacqua E and Farsky SHP (2018). Endogenous annexin A1 (AnxA1) modulates early‐phase gestation and offspring sex‐ratio skewing. Wiley Journal of Cellular Physiology vol. 233, (9) 6591-6603. 10.1002/jcp.26258
Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV and Perretti M (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Ebiomedicine vol. 29, 60-69. 10.1016/j.ebiom.2018.02.003
Oggero S, Norling L and Perretti M (2018). Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases? Japanese Pharmacological Society Proceedings For Annual Meeting of The Japanese Pharmacological Society vol. WCP2018, 10.1254/jpssuppl.wcp2018.0_po1-2-71
2017
Piovezan AP and Perretti M (2017). Potential engagement of pathways of the resolution of inflammation as mechanism of action for plants on animal models. Elsevier Journal of Ethnopharmacology vol. 221, 160-161. 10.1016/j.jep.2017.11.033
Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S and Panigrahy D (2017). Resolvins suppress tumor growth and enhance cancer therapy. Rockefeller University Press Journal of Experimental Medicine vol. 215, (1) 115-140. 10.1084/jem.20170681
Qin CX, Finlayson SB, Ai-Sharea A, Tate M, De Blasio MJ, Deo M, Rosli S, Prakoso D, Thomas CJ, Kiriazis H, Gould E, Yang YH, Morand EF, Perretti M, Murphy AJ, Du X-J, Gao X-M and Ritchie RH (2017). Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo. Macmillan Publishers Limited, Part of Springer Nature Sci Rep vol. 7, (1) 16615-16615. 10.1038/s41598-017-16317-1
Simeoli R, Montague K, Jones HR, Castaldi L, Chambers D, Kelleher JH, Vacca V, Pitcher T, Grist J, Al-Ahdal H, Wong L-F, Perretti M, Lai J, Mouritzen P, Heppenstall P and Malcangio M (2017). Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma. Macmillan Publishers Limited, Part of Springer Nature Nat Commun vol. 8, (1) 1778-1778. 10.1038/s41467-017-01841-5
Perretti M and Montero-Melendez T (2017). Resolution in an 'over-inflamed' era. Biochemist vol. 39, (4) 4-7. 10.1042/bio03904004
Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF, Galvão I, Costa BRC, Soriani FM, Pinho V, Solito E, Perretti M, Teixeira MM and Sousa LP (2017). The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1. Elsevier Journal of Biological Chemistry vol. 292, (33) 13758-13773. 10.1074/jbc.m117.800391
Gittens BR, Bodkin JV, Nourshargh S, Perretti M and Cooper D (2017). Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation. The American Association of Immunologists The Journal of Immunology vol. 198, (11) 4458-4469. 10.4049/jimmunol.1600709
Perretti M and Norling LV (2017). Actions of SPM in regulating host responses in arthritis. Elsevier Molecular Aspects of Medicine vol. 58, 57-64. 10.1016/j.mam.2017.04.005
Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Elsevier Journal of Ethnopharmacology vol. 204, 179-188. 10.1016/j.jep.2017.03.059
Perretti M, Di Filippo C, D'Amico M and Dalli J (2017). Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide. Public Library of Science Plos One vol. 12, (4) e0175786-e0175786. 10.1371/journal.pone.0175786
Brod S, Gobbetti T, Gittens B, Ono M, Perretti M and D’Acquisto F (2017). The impact of environmental enrichment on the murine inflammatory immune response. American Society For Clinical Investigation Jci Insight vol. 2, (7) 10.1172/jci.insight.90723
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and Perretti M (2017). Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates. The American Association of Immunologists The Journal of Immunology vol. 198, (7) 2876-2885. 10.4049/jimmunol.1601111
PERRETTI M, Dalli J, Colas R, Federici Canova D and Gobbetti T (2017). Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 114, (15) 3963-3968. 10.1073/pnas.1617290114
Petri MH, Laguna‐Fernandez A, Arnardottir H, Wheelock CE, Perretti M, Hansson GK and Bäck M (2017). Aspirin‐triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E−/− mice. Wiley British Journal of Pharmacology vol. 174, (22) 4043-4054. 10.1111/bph.13707
Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol vol. 13, (2) 87-99. 10.1038/nrrheum.2016.193
2016
NADKARNI SA, Smith J, Mauro C, Marelli-Berg FM, Perretti M, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Williams DJ and Farsky S (2016). Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy., Editors: Medzhitov R. National Academy of Sciences Proceedings of The National Academy of Sciences of Usa 10.1073/pnas.1611944114
Montero-Melendez T, Forfar RAE, Cook JM, Jerman JC, Taylor DL and Perretti M (2016). Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Springer Nature Cellular and Molecular Life Sciences vol. 74, (7) 1335-1345. 10.1007/s00018-016-2419-3
Simeoli R, Raso GM, Pirozzi C, Lama A, Santoro A, Russo R, Montero‐Melendez T, Canani RB, Calignano A, Perretti M and Meli R (2016). An orally administered butyrate‐releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium‐induced murine colitis. Wiley British Journal of Pharmacology vol. 174, (11) 1484-1496. 10.1111/bph.13637
Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists Journal of Immunology vol. 197, (6) 2362-2368. 10.4049/jimmunol.1502268
Madeira MFM, Queiroz-Junior CM, Montero-Melendez T, Werneck SMC, Correa JD, Soriani FM, Garlet GP, Souza DG, Teixeira MM, Silva TA and Perretti M (2016). Melanocortin agonism as a viable strategy to control alveolar bone loss induced by oral infection. Federation of American Society of Experimental Biology (Faseb) The Faseb Journal 10.1096/fj.201600790R
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology Journal of The American Society of Nephrology 10.1681/ASN.2015060670
Vital SA, Becker F, Holloway PM, Russell J, Perretti M, Granger DN and Gavins FNE (2016). Fpr2/ALX Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease. American Heart Association Circulation 10.1161/CIRCULATIONAHA.115.020633
Sugimoto MA, Sousa LP, Pinho V, Perretti M and Teixeira MM (2016). Resolution of Inflammation: What Controls Its Onset? Frontiers Media Frontiers in Immunology vol. 7, 10.3389/fimmu.2016.00160
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society For Clinical Investigation Jci Insight vol. 1, (5) 10.1172/jci.insight.85922
Jones HR, Robb CT, Perretti M and Rossi AG (2016). The role of neutrophils in inflammation resolution. Seminars in Immunology vol. 28, (2) 137-145. 10.1016/j.smim.2016.03.007
Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T, Perretti M, Papapetropoulos A, Bucci M and Cirino G (2016). d‐Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine‐γ‐lyase. Wiley British Journal of Pharmacology vol. 173, (9) 1556-1565. 10.1111/bph.13459
Machado ID, Spatti M, Hastreiter A, Santin JR, Fock RA, Gil CD, Oliani SM, Perretti M and Farsky SHP (2016). Annexin A1 Is a Physiological Modulator of Neutrophil Maturation and Recirculation Acting on the CXCR4/CXCL12 Pathway. Wiley Journal of Cellular Physiology vol. 231, (11) 2418-2427. 10.1002/jcp.25346
Vago JP, Tavares LP, Sugimoto MA, Lima GLN, Galvão I, de Caux TR, Lima KM, Ribeiro ALC, Carneiro FS, Nunes FFC, Pinho V, Perretti M, Teixeira MM and Sousa LP (2016). Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1. The American Association of Immunologists The Journal of Immunology vol. 196, (4) 1922-1932. 10.4049/jimmunol.1500886
Sinniah A, Yazid S, Perretti M, Solito E and Flower RJ (2016). The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. Elsevier International Immunopharmacology vol. 32, 87-95. 10.1016/j.intimp.2016.01.003
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D'Amico M and Di Filippo C (2016). Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Hindawi Mediators of Inflammation vol. 2016, 10.1155/2016/7368389
2015
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY and Perretti M (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. American Association For The Advancement of Science (Aaas) Science Translational Medicine vol. 7, (315) 10.1126/scitranslmed.aac5608
Perretti M, Leroy X, Bland EJ and Montero-Melendez T (2015). Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation. Elsevier Trends in Pharmacological Sciences vol. 36, (11) 737-755. 10.1016/j.tips.2015.07.007
Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Elsevier Journal of Controlled Release vol. 217, 284-292. 10.1016/j.jconrel.2015.09.021
Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J, Pitzalis C, Perretti M and Dell'Accio F (2015). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Bmj Annals of The Rheumatic Diseases vol. 75, (6) 10.1136/annrheumdis-2015-207316
McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ and Perretti M (2015). Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. The American Association of Immunologists The Journal of Immunology vol. 195, (3) 1139-1151. 10.4049/jimmunol.1500733
Haas R, Smith J, Rocher-Ros V, Nadkarni S, Montero-Melendez T, D’Acquisto F, Bland EJ, Bombardieri M, Pitzalis C, Perretti M, Marelli-Berg FM and Mauro C (2015). Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. Public Library of Science (Plos) Plos Biology vol. 13, (7) 10.1371/journal.pbio.1002202
Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ and Gavins FNE (2015). Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion–Induced Neutrophil Recruitment. Wolters Kluwer Arteriosclerosis Thrombosis and Vascular Biology vol. 35, (9) 1936-1944. 10.1161/atvbaha.115.305348
Kusters DHM, Chatrou ML, Willems BAG, De Saint-Hubert M, Bauwens M, van der Vorst E, Bena S, Biessen EAL, Perretti M, Schurgers LJ and Reutelingsperger CPM (2015). Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. Public Library of Science (Plos) Plos One vol. 10, (6) 10.1371/journal.pone.0130484
Perretti M (2015). The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology. Elsevier Seminars in Immunology vol. 27, (3) 145-148. 10.1016/j.smim.2015.06.001
Trentin PG, Ferreira TPT, Arantes ACS, Ciambarella BT, Cordeiro RSB, Flower RJ, Perretti M, Martins MA and Silva PMR (2015). Peptide Ac2‐26 prevents silicosis. Wiley British Journal of Pharmacology vol. 172, (12) 3058-3071. 10.1111/bph.13109
Flower RJ and Perretti M (2015). R J Flower and M Perretti. Wiley British Journal of Pharmacology vol. 172, (7) 1651-1652. 10.1111/bph.13089
Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TE and Perretti M (2015). Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. The American Association of Immunologists, Inc. J Immunol vol. 194, (7) 3381-3388. 10.4049/jimmunol.1402645
Amoruso A, Fresu LG, Dalli J, Miglietta D, Bardelli C, Canova DF, Perretti M and Brunelleschi S (2015). Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen. Elsevier Life Sciences vol. 126, 28-36. 10.1016/j.lfs.2015.01.025
Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M, Farokzhad O and Tabas I (2015). Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. American Association For The Advancement of Science (Aaas) Science Translational Medicine vol. 7, (275) 10.1126/scitranslmed.aaa1065
Leoni G, Neumann P-A, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS and Nusrat A (2015). Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. American Society For Clinical Investigation Journal of Clinical Investigation vol. 125, (3) 1215-1227. 10.1172/jci76693
Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N and Cenac N (2015). Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. Br J Pharmacol vol. 172, (3) 910-923. 10.1111/bph.12957
2014
Thompson D, McArthur S, Hislop JN, Flower RJ and Perretti M (2014). Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: association with cell protection from apoptosis. J Biol Chem vol. 289, (52) 36166-36178. 10.1074/jbc.M114.612630
Gallo I, Rattazzi L, Piras G, Gobbetti T, Panza E, Perretti M, Dalley JW and D'Acquisto F (2014). Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders. Public Library of Science (Plos) Plos One vol. 9, (12) 10.1371/journal.pone.0114626
Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 111, (52) 18685-18690. 10.1073/pnas.1410938111
Petri MH, Laguna-Fernandez A, Tseng C-N, Hedin U, Perretti M and Bäck M (2014). Aspirin-triggered 15-epi-lipoxin A4 signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation. Elsevier International Journal of Cardiology vol. 179, 370-372. 10.1016/j.ijcard.2014.11.010
Machado ID, Santin JR, Drewes CC, Gil CD, Oliani SM, Perretti M and Farsky SHP (2014). Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions. Am J Physiol Endocrinol Metab vol. 307, (9) E754-E763. 10.1152/ajpendo.00227.2014
Brancaleone V, Mitidieri E, Flower RJ, Cirino G and Perretti M (2014). Annexin A1 mediates hydrogen sulfide properties in the control of inflammation. J Pharmacol Exp Ther vol. 351, (1) 96-104. 10.1124/jpet.114.217034
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F and Perretti M (2014). Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol vol. 91, (3) 348-358. 10.1016/j.bcp.2014.07.034
Montero-Melendez T and Perretti M (2014). Gapdh gene expression is modulated by inflammatory arthritis and is not suitable for qPCR normalization. Inflammation vol. 37, (4) 1059-1069. 10.1007/s10753-014-9829-x
Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D and Perretti M (2014). Resolution of inflammation: examples of peptidergic players and pathways. Drug Discov Today vol. 19, (8) 1166-1171. 10.1016/j.drudis.2014.05.020
Cash JL, Norling LV and Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today vol. 19, (8) 1186-1192. 10.1016/j.drudis.2014.06.023
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol vol. 184, (8) 2333-2341. 10.1016/j.ajpath.2014.04.009
Montero-Melendez T and Perretti M (2014). Connections in pharmacology: innovation serving translational medicine. Drug Discov Today vol. 19, (7) 820-823. 10.1016/j.drudis.2013.11.022
Headland SE, Jones HR, D'Sa ASV, Perretti M and Norling LV (2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep vol. 4, 10.1038/srep05237
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ, Cooper D, Perretti M and Marelli-Berg FM (2014). Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun vol. 5, 10.1038/ncomms4436
Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B and Perretti M (2014). Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression. Circ Res vol. 114, (2) 242-248. 10.1161/CIRCRESAHA.114.301374
Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. Embo Mol Med vol. 6, (1) 27-42. 10.1002/emmm.201303503
Old EA, Nadkarni S, Grist J, Gentry C, Bevan S, Kim K-W, Mogg AJ, Perretti M and Malcangio M (2014). Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. Journal of Clinical Investigation vol. 124, (5) 2023-2036. 10.1172/JCI71389
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S, Parola M, Paternostro C, Bugianesi E, McArthur S, Albano E and Perretti M (2014). Endogenous Annexin A1 Is a Novel Protective Determinant in Nonalcoholic Steatohepatitis in Mice. Hepatology vol. 60, (2) 531-544. 10.1002/hep.27141
Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE-/- mice. Journal of Cellular and Molecular Medicine vol. 18, (10) 2117-2124. 10.1111/jcmm.12374
2013
Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ and Perretti M (2013). Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A vol. 110, (45) 18232-18237. 10.1073/pnas.1308253110
Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V and Perretti M (2013). Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. Embo Rep vol. 14, (11) 999-1007. 10.1038/embor.2013.138
Perretti M, D'Acquisto F and Flower RJ (2013). Annexin-A1 Peptide Ac2-26. Handbook of Biologically Active Peptides 10.1016/B978-0-12-385095-9.00086-5
Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219. 10.1074/mcp.M113.028589
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S and Perretti M (2013). A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood vol. 122, (4) 608-617. 10.1182/blood-2013-04-496661
Iqbal AJ, Cooper D, Vugler A, Gittens BR, Moore A and Perretti M (2013). Endogenous galectin-1 exerts tonic inhibition on experimental arthritis. J Immunol vol. 191, (1) 171-177. 10.4049/jimmunol.1203291
Dalli J, Consalvo AP, Ray V, Di Filippo C, D'Amico M, Mehta N and Perretti M (2013). Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor. J Immunol vol. 190, (12) 6478-6487. 10.4049/jimmunol.1203000
Norling LV and Perretti M (2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol vol. 13, (3) 476-481. 10.1016/j.coph.2013.02.003
Perretti M (2013). SP0144 The Role of Omega-3 Derived Resolvins in Arthritis. Bmj Annals of The Rheumatic Diseases vol. 72, (Suppl 3) 10.1136/annrheumdis-2013-eular.144
Gobbetti T, Ducheix S, Le Faouder P, Boue J, Bertrand-Michel J, Guillou H, Perretti M, Vergnolle N and Cenac N (2013). Tu1993 Protective Effects of N-6 Polyunsaturated Fatty Acid Diet on Intestinal Ischemia/Reperfusion Injury Are Centererd on Lipoxin A4 and Its Receptor. Elsevier Gastroenterology vol. 144, (5) s-899. 10.1016/s0016-5085(13)63349-1
Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI and Brayden DJ (2013). An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis. J Control Release vol. 167, (2) 120-129. 10.1016/j.jconrel.2013.01.027
Montero-Melendez T, Dalli J and Perretti M (2013). Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. Cell Death Differ vol. 20, (4) 567-575. 10.1038/cdd.2012.154
Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P and Dell'Accio F (2013). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. Elsevier Osteoarthritis and Cartilage vol. 21, s112-s113. 10.1016/j.joca.2013.02.238
Rhodes DH, Pini M, Castellanos KJ, Montero-Melendez T, Cooper D, Perretti M and Fantuzzi G (2013). Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function. Obesity (Silver Spring) vol. 21, (2) 310-319. 10.1002/oby.20016
Schutters K, Kusters DHM, Chatrou MLL, Montero-Melendez T, Donners M, Deckers NM, Krysko DV, Vandenabeele P, Perretti M, Schurgers LJ and Reutelingsperger CPM (2013). Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death Differ vol. 20, (1) 49-56. 10.1038/cdd.2012.107
Norling LV and Perretti M (2013). Control of myeloid cell trafficking in resolution. J Innate Immun vol. 5, (4) 367-376. 10.1159/000350612
Ahmed TJ, Montero-Melendez T, Perretti M and Pitzalis C (2013). Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides. Int J Inflam vol. 2013, 10.1155/2013/985815
Godson C and Perretti M (2013). Novel pathways in the yin-yang of immunomodulation. Current Opinion in Pharmacology vol. 13, (4) 543-546. 10.1016/j.coph.2013.06.010
Kosicka A, Cunliffe AD, Mackenzie R, Zariwala MG, Perretti M, Flower RJ and Renshaw D (2013). Attenuation of plasma annexin A1 in human obesity. Faseb Journal vol. 27, (1) 368-378. 10.1096/fj.12-213728
Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N and Perretti M (2013). The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis. Plos One vol. 8, (2) 10.1371/journal.pone.0054299
Leoni G, Alam A, Neumann P-A, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K, Murthy N, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Neish AS and Nusrat A (2013). Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. Journal of Clinical Investigation vol. 123, (1) 443-454. 10.1172/JCI65831
Pang J, Rhodes DH, Pini M, Akasheh RT, Castellanos KJ, Cabay RJ, Cooper D, Perretti M and Fantuzzi G (2013). Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. Plos One vol. 8, (2) 10.1371/journal.pone.0057915
Viiri LE, Full LE, Navin TJ, Begum S, Didangelos A, Astola N, Berge RK, Seppala I, Shalhoub J, Franklin IJ, Perretti M, Lehtimaki T, Davies AH, Wait R and Monaco C (2013). Smooth muscle cells in human atherosclerosis: Proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease. Journal of Molecular and Cellular Cardiology vol. 54, 65-72. 10.1016/j.yjmcc.2012.11.002
Ortega-Gomez A, Perretti M and Soehnlein O (2013). Resolution of inflammation: an integrated view. Embo Molecular Medicine vol. 5, (5) 661-674. 10.1002/emmm.201202382
Fowkes RC, Moradi-Bidhendi N, Branceleone V, Zariwala MG, Brady D, Jessop DS, Perretti M and Renshaw D (2013). Annexin-A1 protein and its relationship to cortisol in human saliva. Psychoneuroendocrinology vol. 38, (5) 722-727. 10.1016/j.psyneuen.2012.08.003
Sampaio ALF, Dalli J, Brancaleone V, D'Acquisto F, Perretti M and Wheatley C (2013). Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression. Mediators Inflamm vol. 2013, 10.1155/2013/741804
Montero-Meléndez T, Llor X, García-Planella E, Perretti M and Suárez A (2013). Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling. Plos One vol. 8, (10) 10.1371/journal.pone.0076235
Perretti M, D’Acquisto F and Flower RJ (2013). Chapter 86 Annexin-A1 Peptide Ac2–26. Handbook of Biologically Active Peptides Elsevier 10.1016/b978-0-12-385095-9.00086-5
2012
Patel HB, Kornerup KN, Sampaio ALF, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C, Oliani SM and Perretti M (2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Ann Rheum Dis vol. 71, (11) 1872-1880. 10.1136/annrheumdis-2011-201180
Perretti M (2012). Editorial: to resolve or not to resolve: annexin A1 pushes resolution on track. J Leukoc Biol vol. 92, (2) 245-247. 10.1189/jlb.0312128
Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol vol. 32, (8) 1970-1978. 10.1161/ATVBAHA.112.249508
Bena S, Brancaleone V, Wang JM, Perretti M and Flower RJ (2012). Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling. J Biol Chem vol. 287, (29) 24690-24697. 10.1074/jbc.M112.377101
Kabouridis PS, Pimentel TA, Brancaleone V, D'Acquisto F, Oliani SM, Perretti M and Jury EC (2012). Distinct localization of T cell Agrin during antigen presentation--evidence for the expression of Agrin receptor(s) in antigen-presenting cells. Febs J vol. 279, (13) 2368-2380. 10.1111/j.1742-4658.2012.08615.x
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and Balkwill FR (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol vol. 227, (2) 136-145. 10.1002/path.4002
Liverani E, Banerjee S, Roberts W, Naseem KM and Perretti M (2012). Prednisolone exerts exquisite inhibitory properties on platelet functions. Biochem Pharmacol vol. 83, (10) 1364-1373. 10.1016/j.bcp.2012.02.006
Patel HB, Kornerup KN, Sampaio ALFS, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C, Oliani SM and Perretti M (2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Annals of The Rheumatic Diseases 10.1136/annrheumdis-2011-201180
Cooper D, Iqbal AJ, Gittens BR, Cervone C and Perretti M (2012). The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? Ann N Y Acad Sci vol. 1253, 181-192. 10.1111/j.1749-6632.2011.06291.x
Vincent TL, Williams RO, Maciewicz R, Silman A, Garside P and group FTARUAMW (2012). Mapping pathogenesis of arthritis through small animal models. Oxford University Press (Oup) Rheumatology vol. 51, (11) 1931-1941. 10.1093/rheumatology/kes035
Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD, Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML and Nourshargh S (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves. Faseb J vol. 26, (3) 1064-1076. 10.1096/fj.11-196220
de Lima CB, Tamura EK, Montero-Melendez T, Palermo-Neto J, Perretti M, Markus RP and Farsky SHP (2012). Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling. Biochem Biophys Res Commun vol. 417, (2) 918-923. 10.1016/j.bbrc.2011.12.078
Dalli J, Jones CP, Cavalcanti DM, Farsky SH, Perretti M and Rankin SM (2012). Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. Faseb J vol. 26, (1) 387-396. 10.1096/fj.11-182089
Vessillier S, Adams G, Montero-Melendez T, Jones R, Seed M, Perretti M and Chernajovsky Y (2012). Molecular engineering of short half-life small peptides (VIP, αMSH and γ₃MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics. Ann Rheum Dis vol. 71, (1) 143-149. 10.1136/annrheumdis-2011-200100
Dalli J, Montero-Melendez T, McArthur S and Perretti M (2012). Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol vol. 3, 10.3389/fphar.2012.00028
Di Filippo C, Perretti M, Rossi F, Ferraraccio F, Motterlini R and D'Amico M (2012). Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn-Schmiedebergs Archives of Pharmacology vol. 385, (2) 137-144. 10.1007/s00210-011-0703-1
Clark AK, Grist J, Al-Kashi A, Perretti M and Malcangio M (2012). Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model. Arthritis and Rheumatism vol. 64, (6) 2038-2047. 10.1002/art.34351
Vong L, Ferraz JGP, Dufton N, Panaccione R, Beck PL, Sherman PM, Perretti M and Wallace JL (2012). Up-Regulation of Annexin-A1 and Lipoxin A4 in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis. Plos One vol. 7, (6) 10.1371/journal.pone.0039244
Cardini S, Dalli J, Fineschi S, Perretti M, Lungarella G and Lucattelli M (2012). Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice. American Journal of Respiratory Cell and Molecular Biology vol. 47, (3) 332-339. 10.1165/rcmb.2012-0036OC
2011
Greco KV, Iqbal AJ, Rattazzi L, Nalesso G, Moradi-Bidhendi N, Moore AR, Goldring MB, Dell'Accio F and Perretti M (2011). High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents. Biochem Pharmacol vol. 82, (12) 1919-1929. 10.1016/j.bcp.2011.09.009
Nadkarni S, Cooper D, Brancaleone V, Bena S and Perretti M (2011). Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes. Arterioscler Thromb Vasc Biol vol. 31, (11) 2749-2759. 10.1161/ATVBAHA.111.235176
Damazo AS, Sampaio AL, Nakata CM, Flower RJ, Perretti M and Oliani SM (2011). Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis. Bmc Immunol vol. 12, 10.1186/1471-2172-12-59
Patel HB, Montero-Melendez T, Greco KV and Perretti M (2011). Melanocortin receptors as novel effectors of macrophage responses in inflammation., Editors: Ariel A. Frontiers in Immunology vol. 2, 1-6. 10.3389/fimmu.2011.00041
Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TEN and Perretti M (2011). The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties. Am J Pathol vol. 179, (1) 259-269. 10.1016/j.ajpath.2011.03.042
Roviezzo F, Brancaleone V, De Gruttola L, Vellecco V, Bucci M, D'Agostino B, Cooper D, Sorrentino R, Perretti M and Cirino G (2011). Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. J Pharmacol Exp Ther vol. 337, (3) 830-837. 10.1124/jpet.111.179168
Maione F, Cicala C, Liverani E, Mascolo N, Perretti M and D'Acquisto F (2011). IL-17A increases ADP-induced platelet aggregation. Biochem Biophys Res Commun vol. 408, (4) 658-662. 10.1016/j.bbrc.2011.04.080
Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J Immunol vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ and Ahluwalia A (2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol vol. 31, (5) 1075-1083. 10.1161/ATVBAHA.111.223545
Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G and Perretti M (2011). Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol vol. 186, (8) 4905-4914. 10.4049/jimmunol.1003145
Montero-Melendez T, Patel HB and Perretti M (2011). Role of melanocortin receptors in the regulation of gouty inflammation. Curr Rheumatol Rep vol. 13, (2) 138-145. 10.1007/s11926-011-0163-0
Iqbal AJ, Sampaio ALF, Maione F, Greco KV, Niki T, Hirashima M, Perretti M and Cooper D (2011). Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. Am J Pathol vol. 178, (3) 1201-1209. 10.1016/j.ajpath.2010.11.073
Gavins FNE, Li G, Russell J, Perretti M and Granger DN (2011). Microvascular thrombosis and CD40/CD40L signaling. J Thromb Haemost vol. 9, (3) 574-581. 10.1111/j.1538-7836.2010.04176.x
Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC, Perretti M and Flower RJ (2011). Corrections: Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation. The American Association of Immunologists The Journal of Immunology vol. 186, (4) 2684-2685. 10.4049/jimmunol.1090139
Allegra M, D'Acquisto F, Tesoriere L, Livrea MA and Perretti M (2011). Cross-talk between minimally primed HL-60 cells and resting HUVEC reveals a crucial role for adhesion over extracellularly released oxidants. Biochem Pharmacol vol. 81, (3) 396-401. 10.1016/j.bcp.2010.10.018
Colucci M, Mastriota M, Maione F, Di Giannuario A, Mascolo N, Palmery M, Severini C, Perretti M and Pieretti S (2011). Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids. Peptides vol. 32, (2) 266-271. 10.1016/j.peptides.2010.11.019
Patel HB, Montero-Melendez T, Greco KV and Perretti M (2011). Melanocortin receptors as novel effectors of macrophage responses in inflammation. Front Immunol vol. 2, 10.3389/fimmu.2011.00041
Pimentel TA, Sampaio ALF, D'Acquisto F, Perretti M and Oliani SM (2011). An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse. Lab Invest vol. 91, (1) 33-42. 10.1038/labinvest.2010.140
2010
Maione F, Paschalidis N, Iqbal AJ, Crompton T, Perretti M and D'Acquisto F (2010). Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells. Autoimmunity vol. 43, (8) 672-681. 10.3109/08916931003678296
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Patel HB, Bombardieri M, Sampaio ALF, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C and Perretti M (2010). Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. Faseb J vol. 24, (12) 4835-4843. 10.1096/fj.10-167759
Pederzoli-Ribeil M, Maione F, Cooper D, Al-Kashi A, Dalli J, Perretti M and D'Acquisto F (2010). Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature. Blood vol. 116, (20) 4288-4296. 10.1182/blood-2010-02-270520
Maderna P, Cottell DC, Toivonen T, Dufton N, Dalli J, Perretti M and Godson C (2010). FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. Faseb J vol. 24, (11) 4240-4249. 10.1096/fj.10-159913
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Spandidos Publications International Journal of Molecular Medicine vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Renshaw D, Montero-Melendez T, Dalli J, Kamal A, Brancaleone V, D'Acquisto F, Cirino G and Perretti M (2010). Downstream gene activation of the receptor ALX by the agonist annexin A1. Plos One vol. 5, (9) 10.1371/journal.pone.0012771
Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M and Flower RJ (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol vol. 30, (9) 1718-1724. 10.1161/ATVBAHA.110.209536
Patel HB, Bombardieri M, Sampaio ALF, D’Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C and Perretti M (2010). Anti‐inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. Wiley The Faseb Journal vol. 24, (12) 4835-4843. 10.1096/fj.10.167759
Dufton N and Perretti M (2010). Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists. Pharmacol Ther vol. 127, (2) 175-188. 10.1016/j.pharmthera.2010.04.010
Dalli J, Rosignoli G, Hayhoe RPG, Edelman A and Perretti M (2010). CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway. Am J Pathol vol. 177, (1) 176-186. 10.2353/ajpath.2010.091149
Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF and Perretti M (2010). Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. J Leukoc Biol vol. 87, (5) 877-884. 10.1189/jlb.1009670
Leoni G, Voisin M-B, Carlson K, Getting S, Nourshargh S and Perretti M (2010). The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. Br J Pharmacol vol. 160, (1) 171-180. 10.1111/j.1476-5381.2010.00688.x
Semple F, Webb S, Li HN, Patel HB, Perretti M, Jackson IJ, Gray M, Davidson DJ and Dorin JR (2010). Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. Eur J Immunol vol. 40, (4) 1073-1078. 10.1002/eji.200940041
Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC, Perretti M and Flower RJ (2010). Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J Immunol vol. 184, (5) 2611-2619. 10.4049/jimmunol.0903526
Sarndahl E, Bergstrom I, Nijm J, Forslund T, Perretti M and Jonasson L (2010). Enhanced neutrophil expression of annexin-1 in coronary artery disease. Metabolism vol. 59, (3) 433-440. 10.1016/j.metabol.2009.07.044
Paschalidis N, Huggins A, Rowbotham NJ, Furmanski AL, Crompton T, Flower RJ, Perretti M and D'Acquisto F (2010). Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. Cell Cycle vol. 9, (4) 785-794. 10.4161/cc.9.4.10673
Patel HB, Leoni G, Melendez TM, Sampaio ALF and Perretti M (2010). Melanocortin Control of Cell Trafficking in Vascular Inflammation. 10.1007/978-1-4419-6354-3_7
Hunter C, Kadakia TB, Cooper D, Perretti M, Schwartz RC and Brown SB (2010). Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands. Thescientificworldjournal vol. 10, 1580-1596. 10.1100/tsw.2010.155
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. International Journal of Molecular Medicine vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Di Filippo C, Monopoli A, Ongini E, Perretti M and D'Amico M (2010). The Cardio-Protective Properties of Ncx-6550, a Nitric Oxide Donating Pravastatin, in the Mouse. Microcirculation vol. 17, (6) 417-426. 10.1111/j.1549-8719.2010.00040.x
Cooper D, Ilarregui JM, Pesoa SA, Croci DO, Perretti M and Rabinovich GA (2010). Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate. 10.1016/S0076-6879(10)80011-4
Spurr L, Nadkarni S, Pederzoli-Ribeil M, Goulding NJ, Perretti M and D'Acquisto F (2010). Comparative analysis of Annexin A1-Formyl Peptide Receptor 2/ALX expression in human leukocyte subsets. Elsevier International Immunopharmacology vol. 11, (1) 55-66. 10.1016/j.intimp.2010.10.006
2009
Paschalidis N, Iqbal AJ, Maione F, Wood EG, Perretti M, Flower RJ and D'Acquisto F (2009). Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1. J Neuroinflammation vol. 6, 10.1186/1742-2094-6-33
Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P, Marrelli A, Pitzalis C, Cipollone F, Schanstra J, Bascands J-L, Hobbs AJ, Perretti M and Ahluwalia A (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol vol. 29, (11) 1757-1763. 10.1161/ATVBAHA.109.191775
Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature vol. 461, (7268) 1287-U125. 10.1038/nature08541
Perretti M and Dalli J (2009). Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics. Br J Pharmacol vol. 158, (4) 936-946. 10.1111/j.1476-5381.2009.00483.x
Pieretti S, Giannuario A, Colucci M, Mastriota M and Perretti M (2009). 297 INVESTIGATION OF THE ROLE OF FORMYL PEPTIDE RECEPTOR IN ACUTE NOCICEPTION USING GENE‐DEFICIENT MICE. Wiley European Journal of Pain vol. 13, (S1) s92a-ss92. 10.1016/s1090-3801(09)60300-1
McColl A, Bournazos S, Franz S, Perretti M, Morgan BP, Haslett C and Dransfield I (2009). Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages. J Immunol vol. 183, (3) 2167-2175. 10.4049/jimmunol.0803503
Dufton NP, Hannon R, Perretti M and Flower R (2009). Quantitative Analysis of Promoter Activity by Green Fluorescent Protein (GFP) Target/Reporter Strategy in a Novel Transgenic alx/fpr-rs2 Null Mouse. Springer Nature Inflammation Research vol. 58, (Suppl 2) s252-s255. 10.1007/bf03354231
Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukocyte Biol vol. 86, (1) 115-122. 10.1189/JLB.0508284
Norling LV, Perretti M and Cooper D (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol vol. 201, (2) 169-184. 10.1677/JOE-08-0512
Patel HB, Bombardieri M, Pitzalis C and Perretti M (2009). Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis. Eur J Clin Invest vol. 39, 29-29.
Pederzoli-Ribeil M, Maione F, Perretti M and D'Acquisto F (2009). The impact of Annexin-A1 cleavage on neutrophil behaviour during vascular inflammation. Eur J Clin Invest vol. 39, 37-37.
Huggins A, Paschalidis N, Flower RJ, Perretti M and D'Acquisto F (2009). Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. Faseb J vol. 23, (4) 985-996. 10.1096/fj.08-119040
Tripatara P, Patel NSA, Brancaleone V, Renshaw D, Rocha J, Sepodes B, Mota-Filipe H, Perretti M and Thiemermann C (2009). Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. Eur J Pharmacol vol. 606, (1-3) 205-209. 10.1016/j.ejphar.2009.01.041
Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M and D'Acquisto F (2009). Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol vol. 77, (5) 878-887. 10.1016/j.bcp.2008.11.011
Hecht I, Rong J, Sampaio ALF, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, Cojocaru G, Zauberman A, Rotman G, Perretti M, Vinten-Johansen J and Cohen Y (2009). A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects. J Pharmacol Exp Ther vol. 328, (2) 426-434. 10.1124/jpet.108.145821
Gastardelo TS, Damazo AS, Dalli J, Flower RJ, Perretti M and Oliani SM (2009). Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation. Am J Pathol vol. 174, (1) 177-183. 10.2353/ajpath.2009.080342
Perretti M and D'Acquisto F (2009). Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol vol. 9, (1) 62-70. 10.1038/nri2470
Laukoetter MG, Babbin BA, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ, Perretti M, Parkos CA and Nusrat A (2009). Annexin A1 reguliert intestinale Mukosaschäden, Entzündung und Regeneration. Chirurgisches Forum Und Dgav Forum 2009 Springer Nature 10.1007/978-3-642-00625-8_84
2008
Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M and Spina D (2008). A role for MC3R in modulating lung inflammation. Pulm Pharmacol Ther vol. 21, (6) 866-873. 10.1016/j.pupt.2008.09.004
Leoni G, Patel HB, Sampaio ALF, Gavins FNE, Murray JF, Grieco P, Getting SJ and Perretti M (2008). Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. Faseb J vol. 22, (12) 4228-4238. 10.1096/fj.08-113886
Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ, Perretti M, Parkos CA and Nusrat A (2008). Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol vol. 181, (7) 5035-5044. 10.4049/jimmunol.181.7.5035
Oliani SM, Ciocca GAP, Pimentel TA, Damazo AS, Gibbs L and Perretti M (2008). Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation. Inflamm Res vol. 57, (10) 450-456. 10.1007/s00011-008-7222-7
Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood vol. 112, (6) 2512-2519. 10.1182/blood-2008-02-140533
D'Acquisto F, Perretti M and Flower RJ (2008). Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. Brit J Pharmacol vol. 155, (2) 152-169. 10.1038/bjp.2008.252
D'Acquisto F and Perretti M (2008). Overview of the Role of Annexin 1 in the Innate and Adaptive Immune Response. Bentham Science Publishers Immunology Endocrine & Metabolic Agents - Medicinal Chemistry vol. 8, (3) 252-258. 10.2174/187152208785748313
Dufton N, Buckingham J, Perretti M and Flower R (2008). Initial characterisation of the novel transgenic, the alx/fpr-rs2 null mouse. Fund Clin Pharmacol vol. 22, 48-48.
Cooper D, Norling LV and Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukocyte Biol vol. 83, (6) 1459-1466. 10.1189/jlb.1207831
D'Acquisto F, Paschalidis N, Raza K, Buckley CD, Flower RJ and Perretti M (2008). Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells. Rheumatology (Oxford) vol. 47, (5) 636-639. 10.1093/rheumatology/ken062
Sarndahl E, Bergstrom I, Nijm J, Perretti M and Jonasson L (2008). ENHANCED NEUTROPHIL EXPRESSION OF ANNEXIN-1 IN CORONARY ARTERY DISEASE. Atherosclerosis Supp vol. 9, (1) 15-15. 10.1016/s1567-5688(08)70055-2
Yona S, Lin HH, Dri P, Davies JQ, Hayhoe RPG, Lewis SM, Heinsbroek SEM, Brown KA, Perretti M, Hamann J, Treacher DF, Gordon S and Stacey M (2008). Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. Faseb J vol. 22, (3) 741-751. 10.1096/fj.07-9435com
Martin GR, Perretti M, Flower RJ and Wallace JL (2008). Annexin-1 modulates repair of gastric mucosal injury. Am J Physiol-Gastr L vol. 294, (3) G764-G769. 10.1152/ajpgi.00531.2007
Norling LV, Sampaio ALF, Cooper D and Perretti M (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. Faseb J vol. 22, (3) 682-690. 10.1096/fj.07-9268com
2007
Finney SJ, Anning PB, Cao TV, Perretti M, Evans TW and Burke-Gaffney A (2007). Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion. Biochem Bioph Res Co vol. 364, (4) 831-837. 10.1016/j.bbrc.2007.10.088
O'Sullivan TP, Vallin KSA, Shah STA, Fakhry J, Maderna P, Scannell M, Sampaio ALF, Perretti M, Godson C and Guiry PJ (2007). Aromatic lipoxin A(4) and lipoxin B-4 analogues display potent biological activities. J Med Chem vol. 50, (24) 5894-5902. 10.1021/jm060270d
D'Acquisto F, Paschalidis N, Sampaio ALF, Merghani A, Flower RJ and Perretti M (2007). Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. Eur J Immunol vol. 37, (11) 3131-3142. 10.1002/eji.200636792
Vong L, D'Acquisto F, Pederzoli-Ribeil M, Lavagno L, Flower RJ, Witko-Sarsat R and Perretti M (2007). Annexin 1 cleavage in activated neutrophils - A pivotal role for proteinase 3. J Biol Chem vol. 282, (41) 29998-30004. 10.1074/jbc.M702876200
Perretti M and Mancini L (2007). Potential of calcitonin as a novel cotreatment for arthritis. Omics International International Journal of Clinical Rheumatology vol. 2, (5) 493-496. 10.2217/17460816.2.5.493
Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M and Ahluwalia A (2007). A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. J Immunol vol. 179, (7) 4849-4856. 10.4049/jimmunol.179.7.4849
Gavins FNE, Dalli J, Flower RJ, Granger DN and Perretti M (2007). Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. Faseb J vol. 21, (8) 1751-1758. 10.1096/fj.06-7842com
Urquhart P, Rosignoli G, Cooper D, Motterlini R and Perretti M (2007). Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow. J Pharmacol Exp Ther vol. 321, (2) 656-662. 10.1124/jpet.106.117218
John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E and Buckingham JC (2007). Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. Faseb J vol. 21, (4) 1037-1046. 10.1096/fj.06-7299com
Giner RM, Mancini L, Kamal AM and Perretti M (2007). Uneven modulation of the annexin 1 system in osteoblast-like cells by dexamethasone. Biochem Bioph Res Co vol. 354, (2) 414-419. 10.1016/j.bbrc.2006.12.224
Mancini L, Paul-Clark MJ, Rosignoli G, Hannon R, Martin JE, Macintyre I and Perretti M (2007). Calcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritis. Am J Pathol vol. 170, (3) 1018-1027. 10.2353/ajpath.2007.060830
Perretti M (2007). Glucocorticoids in innate immunity: more transactivation than transrepression! Blood vol. 109, (3) 852-853. 10.1182/blood-2006-11-056853
Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LAJ, Perretti M, Rossi AG and Wallace JL (2007). Resolution of inflammation: state of the art, definitions and terms. Faseb J vol. 21, (2) 325-332. 10.1096/fj.06-7227rev
D'Acquisto F, Merghani A, Lecona E, Rosignoli G, Raza K, Buckley CD, Flower RJ and Perretti M (2007). Annexin-1 modulates T-cell activation and differentiation. Blood vol. 109, (3) 1095-1102. 10.1182/blood-2006-05-022798
2006
Getting SJ, Lam CW, Leoni G, Gavins FNE, Grieco P and Perretti M (2006). [D-Trp(8)]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol Pharmacol vol. 70, (6) 1850-1855. 10.1124/mol.106.028878
Sawmynaden P and Perretti M (2006). Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes. Biochem Biophys Res Commun vol. 349, (4) 1351-1355. 10.1016/j.bbrc.2006.08.179
Renshaw D, Urquhart P and Perretti M (2006). Therapeutic Exploitation of Endogenous Anti-Inflammatory Mechanisms:Old and New Leads. Bentham Science Publishers Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry vol. 5, (4) 289-305. 10.2174/187152306778772838
Getting SJ, Lam CW, Chen AS, Grieco P and Perretti M (2006). Melanocortin 3 receptors control crystal-induced inflammation. Faseb J vol. 20, (13) 2234-2241. 10.1096/fj.06-6339com
Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E and Perretti M (2006). Antiflammin-2 activates the human formyl-peptide receptor like 1. Scientificworldjournal vol. 6, 1375-1384. 10.1100/tsw.2006.247
Flower RJ, Ayoub S and Perretti M (2006). Anti-inflammatory and analgesic aspects of the annexin A1 system. Acta Pharmacol Sin vol. 27, (9) 1272-1272.
Cassatella MA and Perretti M (2006). Immunomodulation The promises of immunopharmacology for the development of new drugs. Elsevier Current Opinion in Pharmacology vol. 6, (4) 376-378. 10.1016/j.coph.2006.04.003
Flower RJ, Perretti M, D'Acquisto F and Buckingham JC (2006). Annexin 1, anti-inflammatory drugs and the neuroendocrine-immune interface. Acta Pharmacol Sin vol. 27, 13-14.
Yona S, Heinsbroek SEM, Peiser L, Gordon S, Perretti M and Flower RJ (2006). Impaired phagocytic mechanism in annexin 1 null macrophages. Brit J Pharmacol vol. 148, (4) 469-477. 10.1038/sj.bjp.0706730
Perretti M and D'Acquisto F (2006). Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptor. Inflamm Allergy Drug Targets vol. 5, (2) 107-114. 10.2174/187152806776383170
Gil CD, La M, Perretti M and Oliani SM (2006). Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. Cell Biol Int vol. 30, (4) 338-344. 10.1016/j.cellbi.2005.12.010
Damazo AS, Yona S, Flower RJ, Perretti M and Oliani SM (2006). Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J Immunol vol. 176, (7) 4410-4418. 10.4049/jimmunol.176.7.4410
Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D and Perretti M (2006). Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood vol. 107, (5) 2123-2130. 10.1182/blood-2005-08-3099
Getting SJ, Di Filippo C, D'Amico M and Perretti M (2006). The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. Eur J Pharmacol vol. 532, (1-2) 138-144. 10.1016/j.ejphar.2005.12.023
Lam CW, Perretti M and Getting SJ (2006). Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides vol. 27, (2) 404-412. 10.1016/j.peptides.2005.01.031
Perretti M, COOPER D, Gil CD, Oliani SM and Rosignoli G (2006). Inflammation-induced modulation of cellular galectin-1 and –3 expression in a model of rat peritonitis. Inflammation Research vol. 55, (3) 99-107. 10.1007/s00011-005-0059-4
PERRETTI M, Nusrat A, Akyildiz A, Parkos CA, Babbin BA, Lee WY and Winfree LM (2006). Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem vol. 281, 19588-19599. 10.1074/jbc.M513025200
2005
Moraes LA, Paul-Clark MJ, Rickman A, Flower RJ, Goulding NJ and Perretti M (2005). Ligand-specific glucocorticoid receptor activation in human platelets. Blood vol. 106, (13) 4167-4175. 10.1182/blood-2005-04-1723
Bensalem N, Ventura AP, Vallee B, Lipecka J, Tondelier D, Davezac N, Dos Santos A, Perretti M, Fajac A, Sermet-Gaudelus I, Renouil M, Lesure JF, Halgand F, Laprevote O and Edelman A (2005). Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. Mol Cell Proteomics vol. 4, (10) 1591-1601. 10.1074/mcp.M500019-MCP200
Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ and Perretti M (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol vol. 78, (3) 639-646. 10.1189/jlb.0405206
Gilroy DW and Perretti M (2005). Aspirin and steroids: new mechanistic findings and avenues for drug discovery. Curr Opin Pharmacol vol. 5, (4) 405-411. 10.1016/j.coph.2005.02.006
Yona S, Heinsbroek S, Gordon S, Perretti M and Flower RJ (2005). A novel role for Annexin 1 in macrophage phagocytosis. Inflamm Res vol. 54, S217-S218. 10.1007/BF03354055
Marchand F, Perretti M and McMahon SB (2005). Role of the immune system in chronic pain. Nat Rev Neurosci vol. 6, (7) 521-532. 10.1038/nrn1700
Damazo AS, Yona S, D'Acquisto F, Flower RJ, Oliani SM and Perretti M (2005). Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation. Am J Pathol vol. 166, (6) 1607-1617. 10.1016/S0002-9440(10)62471-6
Maderna P, Yona S, Perretti M and Godson C (2005). Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide AC(2-26). J Immunol vol. 174, (6) 3727-3733. 10.4049/jimmunol.174.6.3727
Flower RJ and Perretti M (2005). Controlling inflammation: a fat chance? J Exp Med vol. 201, (5) 671-674. 10.1084/jem.20050222
Kamal AM, Flower RJ and Perretti M (2005). An overview of the effects of annexin 1 on cells involved in the inflammatory process. Mem Inst Oswaldo Cruz vol. 100 Suppl 1, 39-47. 10.1590/s0074-02762005000900008
Zanardo RCO, Perretti M and Wallace JL (2005). Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage. Am J Physiol-Gastr L vol. 288, (3) G481-G486. 10.1152/ajpgi.00299.2004
Basoni C, Nobles M, Grimshaw A, Desgranges C, Davies D, Perretti M, Kramer IM and Genot E (2005). Inhibitory control of TGF-beta 1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes. Faseb J vol. 19, (3) 822-+. 10.1096/fj.04-3085fje
Lam CW, Getting SJ and Perretti M (2005). In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. J Immunol vol. 174, (4) 2297-2304. 10.4049/jimmunol.174.4.2297
Yona S, Ward B, Buckingham JC, Perretti M and Flower RJ (2005). Macrophage biology in the Anx-A1-/- mouse. Prostaglandins Leukot Essent Fatty Acids vol. 72, (2) 95-103. 10.1016/j.plefa.2004.10.008
Flower RJ, PERRETTI M, Diaz BL, Bandeira-Melo C, Martins MA, Carvalho VF, Silva PM, Jose PJ and Bonavita AG (2005). A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat. J Pharmacol Exp Ther vol. 313, (3) 1416-1422. 10.1124/jpet.104.080473
Gavins FNE, Sawmynaden P, Chatterjee BE and Perretti M (2005). A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor. Prostaglandins Leukot Essent Fatty Acids vol. 73, (3-4) 211-219. 10.1016/j.plefa.2005.05.008
Alam CAS, Seed MP, Freemantle C, Brown J, Perretti M, Carrier M, Divwedi A, West DC, Gustafson S, Colville-Nash PR and Willoughby DA (2005). The inhibition of neutrophil-endothelial cell adhesion by hyaluronan independent of CD44. Inflammopharmacology vol. 12, (5-6) 535-550. 10.1163/156856005774382733
Gavins FNE, Kamal AM, D'Amico M, Oliani SM and Perretti M (2005). Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct. Faseb J vol. 19, (1) 100-102. 10.1096/fj.04-2178fje
2004
Cao TV, La M, Getting SJ, Day AJ and Perretti M (2004). Inhibitory effects of TSG-6 link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation vol. 11, (7) 615-624. 10.1080/10739680490503438
Getting SJ, Di Filippo C, Christian HC, Lam CW, Rossi F, D'Amico M and Perretti M (2004). MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. J Leukocyte Biol vol. 76, (4) 845-853. 10.1189/jlb.0306175
Di Filippo C, Rossi F, Ongini E, Del Soldato P, Perretti M and D'Amico M (2004). The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1. J Pharmacol Exp Ther vol. 310, (3) 1133-1141. 10.1124/jpet.104.068726
Yona S, Buckingham JC, Perretti M and Flower RJ (2004). Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. Br J Pharmacol vol. 142, (5) 890-898. 10.1038/sj.bjp.0705858
Perretti M and Flower RJ (2004). Annexin 1 and the biology of the neutrophil. J Leukoc Biol vol. 76, (1) 25-29. 10.1189/jlb.1103552
MARTIN JE, Flower RJ, Perretti M, Hannon R, Getting SJ, Gavins FNE, Christian HC, Parente L, Paul-Clark MJ, Yona S, Oliani SM, Wells D, Cover PO, John CD, Solito E, Morris JF, Buckingham JC, Wells K, Liu K, Croxtall JD and Damazo AS (2004). The Annexin 1-/- Mouse: Phenotypic Studies. Annexins vol. 1, (2) 109-120.
Perretti M and Solito E (2004). Annexin 1 and neutrophil apoptosis. Biochemical Society Transactions vol. 32, 507-510. 10.1042/BST0320507
Pieretti S, Di Giannuario A, De Felice M, Perretti M and Cirino G (2004). Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides. Pain vol. 109, (1-2) 52-63. 10.1016/j.pain.2004.01.009
Gilroy DW, Lawrence T, Perretti M and Rossi AG (2004). Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov vol. 3, (5) 401-416. 10.1038/nrd1383
Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M and Nourshargh S (2004). Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol vol. 172, (7) 4493-4502. 10.4049/jimmunol.172.7.4493
Yang YH, Morand EF, Getting SJ, Paul-Clark M, Liu DL, Yona S, Hannon R, Buckingham JC, Perretti M and Flower RJ (2004). Modulation of inflammation and response to dexamethasone by annexin 1 in antigen-induced arthritis. Arthritis Rheum vol. 50, (3) 976-984. 10.1002/art.20201
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S and Hobbs AJ (2004). Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. P Natl Acad Sci Usa vol. 101, (5) 1386-1391. 10.1073/pnas.0304264101
Baraldi PG, Romagnoli R, Nunez MD, Perretti M, Paul-Clark MJ, Ferrario M, Govoni M, Benedini F and Ongini E (2004). Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide. J Med Chem vol. 47, (3) 711-719. 10.1021/jm030964b
Moraes LA, Giner RM, Paul-Clark MJ, Perretti M and Perrett D (2004). An isocratic HPLC method for the quantitation of eicosanoids in human platelets. Biomed Chromatogr vol. 18, (1) 64-68. 10.1002/bmc.349
PERRETTI M, Oliani SM, Takahashi HK, Damazo AS, Paul-Clark MJ and Straus AH (2004). Analysis of annexin 1 expression in rat trachea: study of mast cell heterogeneity. Annexins vol. 1, 12-18.
2003
Perretti M (2003). The annexin 1 receptor(s): is the plot unravelling? Trends Pharmacol Sci vol. 24, (11) 574-579. 10.1016/j.tips.2003.09.010
La M, Cao TV, Cerchiaro G, Chilton K, Hirabayashi J, Kasao K, Oliani SM, Chernajovsky Y and Perretti M (2003). A novel biological activity for galectin-1 - Inhibition of leukocyte-endothelial cell interactions in experimental inflammation. Am J Pathol vol. 163, (4) 1505-1515. 10.1016/s0002-9440(10)63507-9
Paul-Clark MJ, Roviezzo F, Flower RJ, Cirino G, Del Soldato P, Adcock IM and Perretti M (2003). Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J Immunol vol. 171, (6) 3245-3252. 10.4049/jimmunol.171.6.3245
Getting SJ, Schioth HB and Perretti M (2003). Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. J Pharmacol Exp Ther vol. 306, (2) 631-637. 10.1124/jpet.103.051623
Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S and Perretti M (2003). A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. Faseb J vol. 17, (9) 1544-+. 10.1096/fj.02-0941fje
Gavins FNE, Yona S, Kamal AM, Flower RJ and Perretti M (2003). Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Blood vol. 101, (10) 4140-4147. 10.1182/blood-2002-11-3411
Perretti M, Paul-Clark MJ, Mancini L and Flower RJ (2003). Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids. Digest Liver Dis vol. 35, S41-S48. 10.1016/S1590-8658(03)00051-3
Perretti M and Gavins FNE (2003). Annexin 1: an endogenous anti-inflammatory protein. News Physiol Sci vol. 18, 60-64. 10.1152/nips.01424.2002
Getting SJ, Christian HC, Lam CW, Gavins FNE, Flower RJ, Schioth HB and Perretti M (2003). Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: Studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J Immunol vol. 170, (6) 3323-3330. 10.4049/jimmunol.170.6.3323
Hannon R, Croxtall JD, Getting SJ, Roviezzo F, Yona S, Paul-Clark MJ, Gavins FNE, Perretti M, Morris JF, Buckingham JC and Flower RJ (2003). Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. Faseb J vol. 17, (2) 253-255. 10.1096/fj.02-0239fje
PERRETTI M and Parente L (2003). Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochemical Pharmacology vol. 65, (2) 153-159. 10.1016/s0006-2952(02)01422-3
Perretti M and Getting SJ (2003). Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo. 10.1385/1-59259-374-7:139
Perretti M and Getting SJ (2003). Migration of Specific Leukocyte Subsets in Response to Cytokine or Chemokine Application In Vivo. Inflammation Protocols Springer Nature 10.1385/1-59259-374-7:139
2002
Getting SJ, Mahoney DJ, Cao T, Rugg MS, Fries E, Milner CM, Perretti M and Day AJ (2002). The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem vol. 277, (52) 51068-51076. 10.1074/jbc.M205121200
Fiorucci S, Antonelli E, Distrutti E, Del Soldato P, Flower RJ, Clark MJP, Morelli A, Perretti M and Ignarro LJ (2002). NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. P Natl Acad Sci Usa vol. 99, (24) 15770-15775. 10.1073/pnas.232583599
Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E and Serhan CN (2002). Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med vol. 8, (11) 1296-1302. 10.1038/nm786
Getting SJ, Christian HC, Flower RJ and Perretti M (2002). Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum vol. 46, (10) 2765-2775. 10.1002/art.10526
Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E and Pitzalis C (2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. J Immunol vol. 169, (4) 2085-2092. 10.4049/jimmunol.169.4.2085
Gibbs L, Carollo MG, Damazo AS, Oliani SM and Perretti M (2002). Time-dependent expression of annexin 1 in a model of chronic granulomatous inflammation. Inflamm Res vol. 51, (6) 300-306. 10.1007/pl00000308
Blades MC, Manzo A, Ingegnoli F, Taylor PR, Panayi GS, Irjala H, Jalkanen S, Haskard DO, Perretti M and Pitzalis C (2002). Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J Immunol vol. 168, (9) 4308-4317. 10.4049/jimmunol.168.9.4308
Calatayud S, Mitchell JA, Perretti M, Giuliano F and Warner TD (2002). Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery. Eur J Pharmacol vol. 440, (1) 71-77. 10.1016/s0014-2999(02)01342-0
Ajuebor MN, Swain MG and Perretti M (2002). Chemokines as novel therapeutic targets in inflammatory diseases. Biochem Pharmacol vol. 63, (7) 1191-1196. 10.1016/s0006-2952(02)00854-7
Blades MC, Ingegnoli F, Wheller SK, Manzo A, Wahid S, Panayi GS, Perretti M and Pitzalis C (2002). Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice. Arthritis Rheum vol. 46, (3) 824-836. 10.1002/art.10102
Malcangio M, Getting S, Grist J, Cunningham JR, Bradbury EJ, Issa PC, Lever IJ, Pezet S and Perretti M (2002). A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. Faseb J vol. 16, (3) 730-+. 10.1096/fj.01-0971fje
Paul-Clark MJ, Mancini L, Del Soldato P, Flower RJ and Perretti M (2002). Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis. P Natl Acad Sci Usa vol. 99, (3) 1677-1682. 10.1073/pnas.022641099
PERRETTI M, Damazo AS and Oliani SM (2002). Annexin 1 localisation in tissue eosinophils as detected by electron microscopy. Mediators of Inflammation. vol. 11, 287-292. 10.1080/09629350210000015683
Ingegnoli F, Blades M, Manzo A, Wahid S, Perretti M, Panayi G and Pitzalis C (2002). Role of cell migration in the pathogenesis of rheumatoid arthritis: in vivo studies in SCID mice transplanted with human synovial membrane. Pagepress Publications Reumatismo vol. 54, (2) 128-132. 10.4081/reumatismo.2002.128
Malcangio M, Getting SJ, Grist J, Cunningham JR, Bradbury EJ, Charbel Issa P, Lever IJ, Pezet S and Perretti M (2002). A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. The Faseb Journal : Official Publication of The Federation of American Societies For Experimental Biology vol. 16, (7) 730-732. 10.1096/fj.01-0971fje
PERRETTI M, Manzo A, Wheller SK, Ingegnoli F, Blades MC, Petzalis C, Wahid S and Panayi GS (2002). Stromal cell derived factor-1 (CXCL 12) induces monocyte migration into human synovium transplanted onto SCID mice. Arth Rheum vol. 46, 824-836.
2001
Das AM, Ajuebor MN, Flower RJ, Perretti M and Mccoll SR (2001). Contrasting roles for RANTES and macrophage inflammatory protein‐1α (MIP‐1α) in a murine model of allergic peritonitis. Oxford University Press (Oup) Clinical & Experimental Immunology vol. 117, (2) 223-229. 10.1046/j.1365-2249.1999.00978.x
Carollo M, Hogaboam CM, Kunkel SL, Delaney S, Christie MI and Perretti M (2001). Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1alpha and MCP-1. Br J Pharmacol vol. 134, (6) 1166-1179. 10.1038/sj.bjp.0704371
Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virag L, Szabo E, Soriano FG, Liaudet L, Abdelkarim GE, Hasko G, Marton A, Southan GJ and Szabo C (2001). Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res vol. 50, (11) 561-569. 10.1007/PL00000234
La M, Tailor A, D'Amico M, Flower RJ and Perretti M (2001). Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment. Eur J Pharmacol vol. 429, (1-3) 263-278. 10.1016/s0014-2999(01)01325-5
de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M and Solito E (2001). Cytokine modulation of liver annexin 1 expression during experimental endotoxemia. Am J Pathol vol. 159, (4) 1435-1443. 10.1016/S0002-9440(10)62530-8
Damazo AS, de Lima WT, Perretti M and Oliani SM (2001). Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity. Eur J Pharmacol vol. 426, (1-2) 123-130. 10.1016/s0014-2999(01)01093-7
Getting SJ and Perretti M (2001). Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics. Current Opinion in Investigational Drugs vol. 2, (8) 1064-1069.
Henderson RB, Lim LHK, Tessier PA, Gavins FNE, Mathies M, Perretti M and Hogg N (2001). The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha 4 integrin in the inflammatory response of neutrophils. J Exp Med vol. 194, (2) 219-226. 10.1084/jem.194.2.219
Perretti M, Getting SJ, Solito E, Murphy PM and Gao JL (2001). Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol vol. 158, (6) 1969-1973. 10.1016/S0002-9440(10)64667-6
Diaz B, Barreto E, Cordeiro R, Perretti M, Martins M and Silva P (2001). Enhanced serum glucocorticoid levels mediate the reduction of serosal mast cell numbers in diabetic rats. Life Sci vol. 68, (26) 2925-2932. 10.1016/s0024-3205(01)01087-6
Solito E, de Coupade C, Canaider S, Goulding NJ and Perretti M (2001). Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. Brit J Pharmacol vol. 133, (2) 217-228. 10.1038/sj.bjp.0704054
Blades MC, Ingegnoli F, Manzo A, Wahid S, Haskard D, Panayi G, Perretti M and Pitzalis C (2001). Development of a new model to investigate lymphocyte migration into human peripheral lymph nodes (HPLN) transplanted into SCID mice. Rheumatology vol. 40, 66-66.
Oliani SM, Paul-Clark MJ, Christian HC, Flower RJ and Perretti M (2001). Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression. Am J Pathol vol. 158, (2) 603-615. 10.1016/S0002-9440(10)64002-3
Oliani SM, Lim LHK, Christian HC, Pell K, Das AM and Perretti M (2001). Morphological alteration of peritoneal mast cells and macrophages in the mouse peritoneal cavity during the early phases of an allergic inflammatory reaction. Cell Biol Int vol. 25, (8) 795-803. 10.1006/cbir.2001.0770
PERRETTI M, Obinger C, Furtmuller PG, Allegra M, Regelsberger G, Livrea MA, Tesoriere L and Turco-Leveri ML (2001). Mechanism of Reaction of Melatonin with Human Myeloperoxidase. Biochem Biophys Res Commun. vol. 282, 380-386. 10.1006/bbrc.2001.4582
Pitzalis C, Pipitone N and Perretti M (2001). Glucocorticoids and leukocyte adhesion. Glucocorticoids Springer Nature 10.1007/978-3-0348-8348-1_6
Allcock GH, Allegra M, Flower RJ and Perretti M (2001). Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1. Clin Exp Immunol vol. 123, (1) 62-67. 10.1046/j.1365-2249.2001.01370.x
Getting SJ, Allcock GH, Flower R and Perretti M (2001). Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. J Leukoc Biol vol. 69, (1) 98-104. 10.1189/jlb.69.1.98
2000
Mancini L, Moradi-Bidhendi N, Brandi ML, Perretti M and MacIntyre I (2000). Modulation of the effects of osteoprotegerin (OPG) ligand in a human leukemic cell line by OPG and calcitonin. Biochem Bioph Res Co vol. 279, (2) 391-397. 10.1006/bbrc.2000.3953
Paul‐Clark M, Del Soldato P, Fiorucci S, Flower RJ and Perretti M (2000). 21‐NO‐prednisolone is a novel nitric oxide‐releasing derivative of prednisolone with enhanced anti‐inflammatory properties. Wiley British Journal of Pharmacology vol. 131, (7) 1345-1354. 10.1038/sj.bjp.0703704
McLean PG, Perretti M and Ahluwalia A (2000). Kinin B1 receptors and the cardiovascular system: regulation of expression and function. Oxford University Press (Oup) Cardiovascular Research vol. 48, (2) 194-210. 10.1016/s0008-6363(00)00184-x
D'Amico M, Di Filippo C, La M, Solito E, McLean PG, Flower RJ, Oliani SM and Perretti M (2000). Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment. Faseb J vol. 14, (13) 1867-1869. 10.1096/fj.99-0602fje
Oliani SM, Christian HC, Manston J, Flower RJ and Perretti M (2000). An Immunocytochemical and In Situ Hybridization Analysis of Annexin 1 Expression in Rat Mast Cells: Modulation by Inflammation and Dexamethasone. Elsevier Laboratory Investigation vol. 80, (9) 1429-1438. 10.1038/labinvest.3780150
McLean PG, Ahluwalia A and Perretti M (2000). Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules. Rockefeller University Press Journal of Experimental Medicine vol. 192, (3) 367-380. 10.1084/jem.192.3.367
Perretti M and Page CP (2000). Heparin and inflammation: a new use for an old GAG? Bmj Gut vol. 47, (1) 10.1136/gut.47.1.14
Lim LHK, Flower RJ, Perretti M and Das AM (2000). Glucocorticoid Receptor Activation Reduces CD11b and CD49d Levels on Murine Eosinophils. American Thoracic Society American Journal of Respiratory Cell and Molecular Biology vol. 22, (6) 693-701. 10.1165/ajrcmb.22.6.3890
PERRETTI M and AHLUWALIA A (2000). The Microcirculation and Inflammation: Site of Action for Glucocorticoids. Wiley Microcirculation vol. 7, (3) 147-161. 10.1111/j.1549-8719.2000.tb00117.x
Getting SJ and Perretti M (2000). MC3-R as a novel target for antiinflammatory therapy. Drug News and Perspectives vol. 13, (1) 19-27.
McLean PG, Perretti M and Ahluwalia A (2000). Kinin B1 receptors as novel anti-inflammatory targets. Taylor & Francis Expert Opinion On Therapeutic Targets vol. 4, (2) 127-141. 10.1517/14728222.4.2.127
Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ and Perretti M (2000). Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I). Life Sci vol. 66, (18) PL265-PL270. 10.1016/s0024-3205(00)00500-2
Perretti M, Christian H, Wheller SK, Aiello I, Mugridge KG, Morris JF, Flower RJ and Goulding NJ (2000). ANNEXIN I IS STORED WITHIN GELATINASE GRANULES OF HUMAN NEUTROPHIL AND MOBILIZED ON THE CELL SURFACE UPON ADHESION BUT NOT PHAGOCYTOSIS. Wiley Cell Biology International vol. 24, (3) 163-174. 10.1006/cbir.1999.0468
1999
Tailor A, Tomlinson A, Salas A, Panés J, Granger DN, Flower RJ and Perretti M (1999). Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC. Bmj Gut vol. 45, (5) 10.1136/gut.45.5.705
McLean PG, Perretti M and Ahluwalia A (1999). Inducible expression of the kinin B1 receptor in the endotoxemic heart: mechanisms of des‐Arg9bradykinin‐induced coronary vasodilation. Wiley British Journal of Pharmacology vol. 128, (2) 275-282. 10.1038/sj.bjp.0702743
Getting SJ, Gibbs L, Clark AJL, Flower RJ and Perretti M (1999). POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. The American Association of Immunologists The Journal of Immunology vol. 162, (12) 7446-7453. 10.4049/jimmunol.162.12.7446
Perretti M, Wheller SK, Flower RJ, Wahid S and Pitzalis C (1999). Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. Oxford University Press (Oup) Journal of Leukocyte Biology vol. 65, (5) 583-589. 10.1002/jlb.65.5.583
Ahluwalia A and Perretti M (1999). B1 receptors as a new inflammatory target. Could this B the 1? Elsevier Trends in Pharmacological Sciences vol. 20, (3) 100-104. 10.1016/s0165-6147(99)01321-8
Minghetti L, Nicolini A, Polazzi E, Greco A, Perretti M, Parente L and Levi G (1999). Down‐regulation of microglial cyclo‐oxygenase‐2 and inducible nitric oxide synthase expression by lipocortin 1. Wiley British Journal of Pharmacology vol. 126, (6) 1307-1314. 10.1038/sj.bjp.0702423
Ajuebor MN, Das AM, Virág L, Flower RJ, Szabó C and Perretti M (1999). Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. The American Association of Immunologists The Journal of Immunology vol. 162, (3) 1685-1691. 10.4049/jimmunol.162.3.1685
Ajuebor MN, Das AM, Virág L, Szabó C and Perretti M (1999). Regulation of Macrophage Inflammatory Protein-1α Expression and Function by Endogenous Interleukin-10 in a Model of Acute Inflammation. Elsevier Biochemical and Biophysical Research Communications vol. 255, (2) 279-282. 10.1006/bbrc.1999.0196
Euzger HS, Flower RJ, Goulding NJ and Perretti M (1999). Differential Modulation of Annexin I Binding Sites on Monocytes and Neutrophils. Hindawi Mediators of Inflammation vol. 8, (1) 53-62. 10.1080/09629359990720
Ruetten H, Thiemermann C and Perretti M (1999). Upregulation of ICAM-1 Expression on J774.2 Macrophages by Endotoxin Involves Activation of NF-κB but not Protein Tyrosine Kinase: Comparison to Induction of iNOS. Hindawi Mediators of Inflammation vol. 8, (2) 77-84. 10.1080/09629359990568
1998
AJUEBOR , VIRÁG , FLOWER , PERRETTI and SZABÓ (1998). Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan‐induced inflammation. Wiley Immunology vol. 95, (4) 625-630. 10.1046/j.1365-2567.1998.00644.x
Lim LH, Solito E, Russo-Marie F, Flower RJ and Perretti M (1998). Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A vol. 95, (24) 14535-14539. 10.1073/pnas.95.24.14535
Perretti M (1998). Lipocortin 1 and Chemokine Modulation of Granulocyte and Monocyte Accumulation in Experimental Inflammation. Elsevier Vascular Pharmacology vol. 31, (4) 545-552. 10.1016/s0306-3623(98)00039-1
Ajuebor MN, Gibbs L, Flower RJ, Das AM and Perretti M (1998). Investigation of the functional role played by the chemokine monocyte chemoattractant protein‐1 in interleukin‐1‐induced murine peritonitis. Wiley British Journal of Pharmacology vol. 125, (2) 319-326. 10.1038/sj.bjp.0702071
Das AM, Flower RJ and Perretti M (1998). Resident mast cells are important for eotaxin‐induced eosinophil accumulation in vivo. Oxford University Press (Oup) Journal of Leukocyte Biology vol. 64, (2) 156-162. 10.1002/jlb.64.2.156
Ahluwalia A, De Felipe C, O'Brien J, Hunt SP and Perretti M (1998). Impaired IL‐1β‐induced neutrophil accumulation in tachykinin NK1 receptor knockout mice. Wiley British Journal of Pharmacology vol. 124, (6) 1013-1015. 10.1038/sj.bjp.0701978
Pistritto G, Mancuso C, Tringali G, Perretti M, Preziosi P and Navarra P (1998). The relative contribution of constitutive and inducible cyclooxygenase activity to lipopolysaccharide-induced prostaglandin production by primary cultures of rat hypothalamic astrocytes. Elsevier Neuroscience Letters vol. 246, (1) 45-48. 10.1016/s0304-3940(98)00226-2
Bryant CE, Perretti M and Flower RJ (1998). Suppression by Dexamethasone of Inducible Nitric Oxide Synthase Protein Expression In Vivo A Possible Role for Lipocortin 1. Elsevier Biochemical Pharmacology vol. 55, (3) 279-285. 10.1016/s0006-2952(97)00462-0
Teixeira MM, Das AM, Miotla JM, Perretti M and Hellewell PG (1998). The role of lipocortin‐1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse. Wiley British Journal of Pharmacology vol. 123, (3) 538-544. 10.1038/sj.bjp.0701625
Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A and Perretti M (1998). Endogenous monocyte chemoattractant protein‐1 recruits monocytes in the zymosan peritonitis model. Oxford University Press (Oup) Journal of Leukocyte Biology vol. 63, (1) 108-116. 10.1002/jlb.63.1.108
1997
Cuzzocrea S, Tailor A, Zingarelli B, Salzman AL, Flower RJ, Szabó C and Perretti M (1997). Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration. The American Association of Immunologists The Journal of Immunology vol. 159, (10) 5089-5097. 10.4049/jimmunol.159.10.5089
Perretti M (1997). Endogenous mediators that inhibit the leukocyte– endothelium interaction. Elsevier Trends in Pharmacological Sciences vol. 18, (11) 418-425. 10.1016/s0165-6147(97)01116-4
Szabó C, Lim LHK, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, Salzman AL and Perretti M (1997). Inhibition of poly (ADP-ribose) Synthetase Attenuates Neutrophil Recruitment and Exerts Antiinflammatory Effects. Rockefeller University Press Journal of Experimental Medicine vol. 186, (7) 1041-1049. 10.1084/jem.186.7.1041
Getting SJ, Flower RJ, Parente L, de Medicis R, Lussier A, Woliztky BA, Martins MA and Perretti M (1997). Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Journal of Pharmacology and Experimental Therapeutics vol. 283, (1) 123-130.
Tailor A, Flower RJ and Perretti M (1997). Dexamethasone inhibits leukocyte emigration in rat mesenteric post‐capillary venules: an intravital microscopy study. Oxford University Press (Oup) Journal of Leukocyte Biology vol. 62, (3) 301-308. 10.1002/jlb.62.3.301
Das AM, Flower RJ and Perretti M (1997). Eotaxin-induced eosinophil migration in the peritoneal cavity of ovalbumin-sensitized mice: mechanism of action. The American Association of Immunologists The Journal of Immunology vol. 159, (3) 1466-1473. 10.4049/jimmunol.159.3.1466
Ferreira SH, Cunha FQ, Lorenzetti BB, Michelin MA, Perretti M, Flower RJ and Poole S (1997). Role of lipocortin‐1 in the anti‐hyperalgesic actions of dexamethasone. Wiley British Journal of Pharmacology vol. 121, (5) 883-888. 10.1038/sj.bjp.0701211
Wheller SK and Perretti M (1997). Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines. Elsevier European Journal of Pharmacology vol. 331, (1) 65-71. 10.1016/s0014-2999(97)01015-7
Das AM, Flower RJ, Hellewell PG, Teixeira MM and Perretti M (1997). A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment. Wiley British Journal of Pharmacology vol. 121, (1) 97-104. 10.1038/sj.bjp.0701122
Getting SJ, Flower RJ and Perretti M (1997). Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. Wiley British Journal of Pharmacology vol. 120, (6) 1075-1082. 10.1038/sj.bjp.0701029
Tailor A, Das AM, Getting SJ, Flower RJ and Perretti M (1997). Subacute Treatment of Rats with Dexamethasone Reduces ICAM-1 Levels on Circulating Monocytes. Elsevier Biochemical and Biophysical Research Communications vol. 231, (3) 675-678. 10.1006/bbrc.1997.6168
Das AM, Lim LHK, Flower RJ and Perretti M (1997). Dexamethasone reduces cell surface levels of CD11b on human eosinophils. Hindawi Mediators of Inflammation vol. 6, (5-6) 363-367. 10.1080/09629359791505
1996
Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon R and Flower RJ (1996). Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Springer Nature Nature Medicine vol. 2, (11) 1259-1262. 10.1038/nm1196-1259
Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA and Perretti M (1996). Relative Contribution of the Selectins in the Neutrophil Recruitment Caused by the Chemokine Cytokine-Induced Neutrophil Chemoattractant (CINC) Volume221,Number 3 (1996), pages 692–696. Elsevier Biochemical and Biophysical Research Communications vol. 224, (3) 878-879. 10.1006/bbrc.1996.1117
Perretti M, Wheller SK, Harris JG and Flower RJ (1996). Modulation of ICAM-1 Levels on U-937 Cells and Mouse Macrophages by Interleukin-1β and Dexamethasone. Elsevier Biochemical and Biophysical Research Communications vol. 223, (1) 112-117. 10.1006/bbrc.1996.0854
Perretti M and Flower RJ (1996). Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation. Wiley British Journal of Pharmacology vol. 118, (3) 605-610. 10.1111/j.1476-5381.1996.tb15444.x
Harris JG, Flower RJ, Watanabe K, Tsurufuji S, Wolitzky BA and Perretti M (1996). Relative Contribution of the Selectins in the Neutrophil Recruitment Caused by the Chemokine Cytokine-Induced Neutrophil Chemoattractant (CINC). Elsevier Biochemical and Biophysical Research Communications vol. 221, (3) 692-696. 10.1006/bbrc.1996.0658
Malcangio M, Bowery NG, Flower RJ and Perretti M (1996). Effect of interleukin-1β on the release of substance P from rat isolated spinal cord. Elsevier European Journal of Pharmacology vol. 299, (1-3) 113-118. 10.1016/0014-2999(95)00845-4
Perretti M, Ahluwalia A, Harris JG, Harris HJ, Wheller SK and Flower RJ (1996). Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. Wiley British Journal of Pharmacology vol. 117, (6) 1145-1154. 10.1111/j.1476-5381.1996.tb16709.x
Ahluwalia A and Perretti M (1996). Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse. The American Association of Immunologists The Journal of Immunology vol. 156, (1) 269-274. 10.4049/jimmunol.156.1.269
1995
Mugridge KG, Perretti M, Ghiara P, Galeotti CL, Melli M and Parente L (1995). Gastric antisecretory and anti-ulcer actions of IL-1 in rat involve different IL-1 receptor types. American Physiological Society American Journal of Physiology vol. 269, (5) g763-g769. 10.1152/ajpgi.1995.269.5.g763
Perretti M, Szabó C and Thiemermann C (1995). Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse. Wiley British Journal of Pharmacology vol. 116, (4) 2251-2257. 10.1111/j.1476-5381.1995.tb15061.x
Perretti M, Wheller SK, Choudhury Q, Croxtall JD and Flower RJ (1995). Selective inhibition of neutrophil function by a peptide derived from lipocortin 1 N-terminus. Elsevier Biochemical Pharmacology vol. 50, (7) 1037-1042. 10.1016/0006-2952(95)00238-u
Harris JG, Flower RJ and Perretti M (1995). Endogenous corticosteroids mediate the neutrophilia caused by platelet-activating factor in the mouse. Elsevier European Journal of Pharmacology vol. 283, (1-3) 9-18. 10.1016/0014-2999(95)00274-o
Mancuso F, Flower RJ and Perretti M (1995). Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. Involvement of endogenous lipocortin 1. The American Association of Immunologists The Journal of Immunology vol. 155, (1) 377-386. 10.4049/jimmunol.155.1.377
Klemm P, Harris HJ and Perretti M (1995). Effect of rolipram in a murine model of acute inflammation: comparison with the corticoid dexamethasone. Elsevier European Journal of Pharmacology vol. 281, (1) 69-74. 10.1016/0014-2999(95)00232-a
Palmi M, Frosini M, Sgaragli GP, Becherucci C, Perretti M and Parente L (1995). Inhibition of interleukin-1β-induced pyresis in the rabbit by peptide 204–212 of lipocortin 5. Elsevier European Journal of Pharmacology vol. 281, (1) 97-99. 10.1016/0014-2999(95)00304-4
Harris JG, Flower RJ and Perretti M (1995). Alteration of neutrophil trafficking by a lipocortin 1 N-terminus peptide. Elsevier European Journal of Pharmacology vol. 279, (2-3) 149-157. 10.1016/0014-2999(95)00145-b
Wu CC, Croxtall JD, Perretti M, Bryant CE, Thiemermann C, Flower RJ and Vane JR (1995). Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 92, (8) 3473-3477. 10.1073/pnas.92.8.3473
Perretti M and Flower RJ (1995). Anti-Inflammatory Lipocortin-Derived Peptides. Novel Molecular Approaches to Anti-Inflammatory Therapy 10.1007/978-3-0348-7276-8_13
1994
Ahluwalia A and Perretti M (1994). Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. Elsevier European Journal of Pharmacology vol. 264, (3) 407-415. 10.1016/0014-2999(94)00503-6
Perretti M and Flower RJ (1994). Cytokines, glucocorticoids and lipocortins in the control of neutrophil migration. Elsevier Pharmacological Research vol. 30, (1) 53-59. 10.1016/1043-6618(94)80087-1
Perretti M, Harris JG and Flower RJ (1994). A role for endogenous histamine in interleukin‐8‐induced neutrophil infiltration into mouse air‐pouch: investigation of the modulatory action of systemic and local dexamethasone. Wiley British Journal of Pharmacology vol. 112, (3) 801-808. 10.1111/j.1476-5381.1994.tb13150.x
Ahluwalia A and Perretti M (1994). Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors. Journal of Pharmacology and Experimental Therapeutics vol. 268, (3) 1526-1531.
Perretti M (1994). Lipocortin-derived peptides. Elsevier Biochemical Pharmacology vol. 47, (6) 931-938. 10.1016/0006-2952(94)90402-2
Szabó C, Thiemermann C, Wu CC, Perretti M and Vane JR (1994). Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 91, (1) 271-275. 10.1073/pnas.91.1.271
1993
Perretti M, Ahluwalia A, Harris JG, Goulding NJ and Flower RJ (1993). Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. The American Association of Immunologists The Journal of Immunology vol. 151, (8) 4306-4314. 10.4049/jimmunol.151.8.4306
Perretti M, Duncan GS, Flower RJ and Peers SH (1993). Serum corticosterone, interleukin‐1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains. Wiley British Journal of Pharmacology vol. 110, (2) 868-874. 10.1111/j.1476-5381.1993.tb13893.x
Perretti M, Ahluwalia A, Flower RJ and Manzini S (1993). Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors. Immunology vol. 80, (1) 73-77.
Thiemermann C, Wu C, Szabó C, Perretti M and Vane JR (1993). Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. Wiley British Journal of Pharmacology vol. 110, (1) 177-182. 10.1111/j.1476-5381.1993.tb13789.x
Perretti M, Flower RJ and Goulding NJ (1993). The Ability of Murine Leukocytes to Bind Lipocortin 1 Is Lost during Acute Inflammation. Elsevier Biochemical and Biophysical Research Communications vol. 192, (2) 345-350. 10.1006/bbrc.1993.1421
Cirino G, Cicala C, Sorrentino L, Ciliberto G, Arpaia G, Perretti M and Flower RJ (1993). Anti‐inflammatory actions of an N‐terminal peptide from human lipocortin 1. Wiley British Journal of Pharmacology vol. 108, (3) 573-574. 10.1111/j.1476-5381.1993.tb12843.x
Da Silva JA, Peers SH, Perretti M and Willoughby DA (1993). Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1. Bioscientifica Journal of Endocrinology vol. 136, (3) 389-397. 10.1677/joe.0.1360389
Perretti M and Flower RJ (1993). Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1. The American Association of Immunologists The Journal of Immunology vol. 150, (3) 992-999. 10.4049/jimmunol.150.3.992
Mugridge KG, Becherucci C, Parente L and Perretti M (1993). Inhibition of smooth muscle contraction and platelet aggregation by peptide 204–212 of lipocortin 5: an attempt to define some structure requirements. Hindawi Mediators of Inflammation vol. 2, (2) 103-107. 10.1155/s0962935193000146
Becherucci C, Perretti M, Solito E, Galeotti CL and Parente L (1993). Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5. Mediators Inflamm vol. 2, (2) 109-113. 10.1155/S0962935193000158
1992
Douglas GJ, Flower RJ, Parente L and Perretti M (1992). Peptide 204–212 of lipocortin 5 inhibits the generation of a prostacyclin-like factor from rat aorta preparations in vitro. Elsevier Prostaglandins vol. 44, (5) 381-388. 10.1016/0090-6980(92)90134-f
Parente L, Perretti M, Wallace JL and Mugridge KG (1992). Mechanism of the protective action of interleukin-1 in the experimental gastric damage in the rat. Elsevier Pharmacological Research vol. 26, 28-29. 10.1016/1043-6618(92)90584-x
Perretti M, Mugridge KG, Wallace JL and Parente L (1992). Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids. Journal of Pharmacology and Experimental Therapeutics vol. 261, (3) 1238-1247.
Becherucci C, Perretti M, Nencioni L, Silvestri S and Parente L (1992). Anti-inflammatory effect of tuftsin and its retro-inverso analogue in rat adjuvant arthritis. Springer Nature Inflammation Research vol. 36, (Suppl 1) c115-c117. 10.1007/bf01991043
Perretti M, Solito E and Parente L (1992). Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice. Agents Actions vol. 35, (1-2) 71-78. 10.1007/BF01990954
1991
Verdini AS, Silvestri S, Becherucci C, Longobardi MG, Parente L, Peppoloni S, Perretti M, Pileri P, Pinori M and Viscomi GC (1991). Immunostimulation by a partially modified retro-inverso-tuftsin analogue containing Thr1 psi[NHCO](R,S)Lys2 modification. American Chemical Society (Acs) Journal of Medicinal Chemistry vol. 34, (12) 3372-3379. 10.1021/jm00116a005
Perretti M, Mugridge KG, Becherucci C and Parente L (1991). Evidence that interleukin-1 and lipoxygenase metabolites mediate the lethal effect of complete Freund's adjuvant in adrenalectomized rats. Journal of Interferon & Cytokine Research vol. 10, (4) 239-243.
Perretti M, Becherucci C, Mugridge KG, Solito E, Silvestri S and Parente L (1991). A novel anti-inflammatory peptide from human lipocortin 5. Br J Pharmacol vol. 103, (2) 1327-1332. 10.1111/j.1476-5381.1991.tb09788.x
Mugridge KG, Perretti M, Ghiara P and Parente L (1991). α-melanocyte-stimulating hormone reduces interleukin-lβ effects on rat stomach preparations possibly through interference with a type I receptor. Elsevier European Journal of Pharmacology vol. 197, (2-3) 151-155. 10.1016/0014-2999(91)90514-q
Dal Piaz V, Ciciani G, Turco G, Giovannoni MP, Miceli M, Pirisino R and Perretti M (1991). 5‐Acyl‐6‐Aryl‐4‐Nitro‐3(2HH)Pyridazinones and related 4‐amino compounds: Synthesis and pharmacological evaluation. Elsevier Journal of Pharmaceutical Sciences vol. 80, (4) 341-348. 10.1002/jps.2600800412
Mugridge KG, Perretti M and Parente L (1991). 5-Lipoxygenase activation may facilitate an interleukin-1 transduction signal. Advances in Prostaglandin, Thromboxane, and Leukotriene Research vol. 21B, 517-520.
Mugridge KG, Perretti M, Becherucci C and Parente L (1991). Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase. Journal of Pharmacology and Experimental Therapeutics vol. 256, (1) 29-37.
1990
Perretti M, Mugridge KG, Becherucci C, Silvestri S and Parente L (1990). Antiulcer property of human recombinant interleukin-1β. Elsevier Pharmacological Research vol. 22, 10.1016/1043-6618(90)90427-f
Parente L, Mugridge KG, Perretti M and Solito E (1990). In vitro and in vivo activation of phospholipase A2 by interleukin-1. Elsevier Pharmacological Research vol. 22, 10.1016/1043-6618(90)90413-8
Becherucci C, Perretti M, Galeotti C and Parente L (1990). Different anti-inflammatory effects of lipocortins 1 and 5. Elsevier Pharmacological Research vol. 22, 10.1016/s1043-6618(09)80089-3
Perretti M, Nuti S and Parente L (1990). Investigation of rat mast cell degranulation using flow cytometry. Elsevier Journal of Pharmacological Methods vol. 23, (3) 187-194. 10.1016/0160-5402(90)90062-p
Becherucci C, Solito E, Perretti M, Mugridge KG, Galeotti CL and Parente L (1990). Purification and biological activity of human lipocortin 2. Pharmacol Res vol. 22 Suppl 1, 29-30. 10.1016/1043-6618(90)90792-c
Parente L, Becherucci C, Perretti M, Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M and Sanso M (1990). Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids? Prog Clin Biol Res vol. 349, 55-68.
1989
Perretti M, Becherucci C, Scapigliati G and Parente L (1989). The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo. Wiley British Journal of Pharmacology vol. 98, (4) 1137-1142. 10.1111/j.1476-5381.1989.tb12657.x
Becherucci C, Donati D, Perretti M and Parente L (1989). The release of interleukin-1-like activity by macrophages in two models of immunological inflammation in the rat. Springer Nature Inflammation Research vol. 28, (3-4) 243-247. 10.1007/bf01967410
1988
Perretti M, Becherucci C and Parente L (1988). Interleukin-1 release by macrophages from adrenalectomized (ADX) and shamoperated (SHO) rats. Elsevier Pharmacological Research Communications vol. 20, 10.1016/s0031-6989(88)80429-6
Becherucci C, Donati D, Perretti M and Parente L (1988). Interleukin-1 release by rat macrophages in experimental immunological inflammation. Elsevier Pharmacological Research Communications vol. 20, 10.1016/s0031-6989(88)80159-0
Ignesti G, Buffoni F, Perretti M and Cintelli A (1988). Induction and quail liver diamine oxidase (histaminase). Part II: Different responses to the inducers. Springer Nature Inflammation Research vol. 25, (1-2) 43-47. 10.1007/bf01969092
Ignesti G, Perretti M and Buffoni F (1988). Induction and quail liver diamine oxidase (histaminase). Part I: Interference of spermidine synthase on the diamine oxidase activity assay using putrescine as substrate. Springer Nature Inflammation Research vol. 25, (1-2) 37-42. 10.1007/bf01969091
1986
Ignesti G, Perretti M and Buffoni F (1986). Diamine oxidase activity in Japanese quail liver induced with Aroclor 1254. Springer Nature Inflammation Research vol. 18, (1-2) 41-43. 10.1007/bf01987977
1981
Bombardieri G, Bevilacqua E, Conti LR, Innocenti P and Perretti MA (1981). Plasma amine oxidases in Wilson's disease. Elsevier Life Sciences vol. 29, (2) 117-120. 10.1016/0024-3205(81)90279-4
Grants
Grants of specific relevance to Predictive in vitro Models
Analysis of novel melanocortin receptor peptide agonists - phase 2
Perretti M and Montero Melendez T
£374,313 TXP Pharma / WHRL (01-09-2021 - 31-03-2025)
Perretti M and Montero Melendez T
£374,313 TXP Pharma / WHRL (01-09-2021 - 31-03-2025)
New therapeutic targets for treating the failing heart in arthritis.
Perretti M and Cooper D
£115,000 Chernajovsky Foundation (01-04-2021 - 31-03-2024)
Perretti M and Cooper D
£115,000 Chernajovsky Foundation (01-04-2021 - 31-03-2024)
Analysis of novel melanocortin receptor peptide agonists - phase 2
Perretti M and Montero-Melendez T
£374,000 William Harvey Research Foundation (01-06-2021 - 31-05-2023)
Perretti M and Montero-Melendez T
£374,000 William Harvey Research Foundation (01-06-2021 - 31-05-2023)
Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis
Perretti M and Norling L
£230,000 EU (01-03-2019 - 28-02-2023)
Perretti M and Norling L
£230,000 EU (01-03-2019 - 28-02-2023)
Cardiomyopathy in RA
Perretti M, Norling L, Cooper D and Chen J
£230,000 Bristol-Myers Squibb (01-06-2021 - 30-11-2022)
Perretti M, Norling L, Cooper D and Chen J
£230,000 Bristol-Myers Squibb (01-06-2021 - 30-11-2022)
Marie Sklodowska-Curie Doctoral Training Progamme ‘‘Arthritis Heal’
Norling L and Perretti M
£280,000 European Union’s Horizon 2020 Research and Innovation programme (01-10-2019 - 30-09-2022)
Norling L and Perretti M
£280,000 European Union’s Horizon 2020 Research and Innovation programme (01-10-2019 - 30-09-2022)
A New Therapeutic Approach to Cardioprotection for Myocardial Infarct Patients
Perretti M, CHEN J and Oggero S
£490,000 Barts Charity (01-03-2020 - 28-02-2022)
Perretti M, CHEN J and Oggero S
£490,000 Barts Charity (01-03-2020 - 28-02-2022)
EVOLuTION - European Vascular Interventions and Therapeutic Innovation Network
Perretti M and Oggero S
£725,000 EU (01-04-2016 - 31-03-2021)
Perretti M and Oggero S
£725,000 EU (01-04-2016 - 31-03-2021)
Cloning and Validation of an anti-arthritic ACTH species devoid of side effects
Perretti M and Montero-Melendez
£217,000 Versus Arthritis UK (01-10-2016 - 30-09-2019)
Perretti M and Montero-Melendez
£217,000 Versus Arthritis UK (01-10-2016 - 30-09-2019)
Neutrophil Vesicles as a novel auto logous regenerative therapeutic for joint disease
Perretti M, Thomas B, Dell'Accio F and Pitzalis C
£236,000 MRC (04-09-2017 - 03-09-2019)
Perretti M, Thomas B, Dell'Accio F and Pitzalis C
£236,000 MRC (04-09-2017 - 03-09-2019)
Treating the host in Dengue: mediators and pathways of resolution as a new therapeutic paradigm
Perretti M, Teixeira MMM, Pinho VS, Santiago HDC, Haworth OJ, Sousa LPD and Souza DG
£242,838 Medical Research Council (14-01-2016 - 13-01-2019)
Perretti M, Teixeira MMM, Pinho VS, Santiago HDC, Haworth OJ, Sousa LPD and Souza DG
£242,838 Medical Research Council (14-01-2016 - 13-01-2019)
The use of a combined flow cytometer/microscopy imaging platform for analysis of cellular phenotypic and functional profiles in inflammation and cancer.
Nourshargh S, Marelli-Berg FM, Hagemann T, Goulding NJ, Capasso M, Balkwill FR, Perretti M, Warner TD and Vanhaesebroeck BAM
£399,636 Wellcome Trust (01-07-2013 - 30-06-2018)
Nourshargh S, Marelli-Berg FM, Hagemann T, Goulding NJ, Capasso M, Balkwill FR, Perretti M, Warner TD and Vanhaesebroeck BAM
£399,636 Wellcome Trust (01-07-2013 - 30-06-2018)
Targeting Feutin-A as an innovative chondroprotective strategy
Perretti M and Kaneva M
William Harvey Research Limited (01-03-2014 - 28-02-2018)
Perretti M and Kaneva M
William Harvey Research Limited (01-03-2014 - 28-02-2018)
Translating the Resolution of Inflammation: MC3 in human arthritis synovia
Perretti M, Montero Melendez T, Pitzalis C and Bombardieri M
£352,593 Medical Research Council (01-03-2013 - 29-02-2016)
Perretti M, Montero Melendez T, Pitzalis C and Bombardieri M
£352,593 Medical Research Council (01-03-2013 - 29-02-2016)
The patho-physiology of the ALX receptor in inflammation.
Perretti M and Flower RJ
£1,167,240 Wellcome Trust (02-03-2009 - 01-07-2014)
Perretti M and Flower RJ
£1,167,240 Wellcome Trust (02-03-2009 - 01-07-2014)
OMRAS2: A Distributed Research Environment for Music Informatics and Computational Musicology
Perretti M, Sandler M, Abdallah S, Bello JP, Dixon S and Plumbley M
£1,447,586 Engineering and Physical Sciences Research Council (01-02-2007 - 30-10-2010)
Perretti M, Sandler M, Abdallah S, Bello JP, Dixon S and Plumbley M
£1,447,586 Engineering and Physical Sciences Research Council (01-02-2007 - 30-10-2010)
Mechanisms regulating expression and function of the kinin B1 receptor in cardiovascular inflammation.
Ahluwalia A and Perretti M
£299,837 Wellcome Trust (01-11-2002 - 31-07-2007)
Ahluwalia A and Perretti M
£299,837 Wellcome Trust (01-11-2002 - 31-07-2007)