Dr Lucy Norling
Versus Arthritis Senior Fellow /
(Responsible for ECR Engagement, Social Media and Public Engagement)
Centre for Biochemical Pharmacology
School of Medicine and Dentistry
l.v.norling@qmul.ac.ukSchool of Medicine and Dentistry
www.qmul.ac.uk/whri/people/academic-staff/items/norlinglucy.html
Research
Musculoskeletal, Leukocyte Trafficking, Omega-3, Chemotaxis
Interests
My research group is interested in how omega-3 derived lipid mediators can protect and repair joint tissues. I have a keen interest in the development of human in vitro models to mimic various aspects of the inflammatory response including leukocyte-endothelial interactions, cell chemotaxis, phagocytosis and efferocytosis as well as the development of musculoskeletal models.Publications
2020
Norling LV and Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of The National Academy of Sciences of The United States of America vol. 117, (17) 9148-9150. 10.1073/pnas.2004241117Norling L, Cooper D, Law H, Wright R and Iqbal A (2020). A pro-resolving role for Galectin-1 in acute inflammation. Frontiers Media Frontiers in Pharmacology vol. 11, (274) 10.3389/fphar.2020.00274Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media Frontiers in Immunology vol. 11, 10.3389/fimmu.2020.00010Padovan MG and Norling LV (2020). Pro-resolving lipid mediators in sepsis and critical illness. Ovid Technologies (Wolters Kluwer Health) Current Opinion in Clinical Nutrition and Metabolic Care 1-1. 10.1097/mco.00000000000006332019
Oggero S, Austin-Williams S and Norling LV (2019). The contrasting role of extracellular vesicles in vascular inflammation and tissue repair. Frontiers Media Frontiers in Pharmacology vol. 10, 10.3389/fphar.2019.014792018
(2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Ebiomedicine vol. 29, 60-69. 10.1016/j.ebiom.2018.02.0032017
Perretti M and Norling LV (2017). Actions of SPM in regulating host responses in arthritis. Molecular Aspects of Medicine vol. 58, 57-64. 10.1016/j.mam.2017.04.005Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Journal of Ethnopharmacology vol. 204, 179-188. 10.1016/j.jep.2017.03.059 (2017). Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. Annals of The Rheumatic Diseases vol. 76, (3) 612-619. 10.1136/annrheumdis-2016-209424Norling LV, Ly L and Dalli J (2017). Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care vol. 20, (2) 145-152. 10.1097/MCO.0000000000000353Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol vol. 13, (2) 87-99. 10.1038/nrrheum.2016.193Souza PR, Jones HR and Norling LV (2017). Novel immunoregulatory mediators produced from omega-3 fatty acids. Nutrition, Immunity, and Infection 10.1201/97813151189012016
Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV and Cooper D (2016). Galectin-3-null mice display defective neutrophil clearance during acute inflammation., Editors: Montaner LJ. The Society For Leukocyte Biology J Leukoc Biol 10.1189/jlb.3A0116-026RRArnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists Journal of Immunology vol. 197, (6) 2362-2368. 10.4049/jimmunol.1502268Souza PR and Norling LV (2016). Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. European Journal of Pharmacology vol. 785, 165-173. 10.1016/j.ejphar.2015.05.072Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. Jci Insight vol. 1, (5) 10.1172/jci.insight.859222015
(2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Science Translational Medicine vol. 7, (315) 10.1126/scitranslmed.aac5608Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Journal of Controlled Release vol. 217, 284-292. 10.1016/j.jconrel.2015.09.021Headland SE and Norling LV (2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology vol. 27, (3) 149-160. 10.1016/j.smim.2015.03.014Headland S, Norling L, Kim A, Jones H, Jan L and Perretti M (2015). Neutrophil-Derived Microvesicles Migrate into Cell-Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis. Faseb Journal vol. 29, Headland SE and Norling LV (2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology 10.1016/j.smim.2015.03.0142014
Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine vol. 18, (10) 2117-2124. 10.1111/jcmm.12374Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol vol. 184, (8) 2333-2341. 10.1016/j.ajpath.2014.04.009Cash JL, Norling LV and Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today vol. 19, (8) 1186-1192. 10.1016/j.drudis.2014.06.023 (2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep vol. 4, 10.1038/srep05237Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. Embo Mol Med vol. 6, (1) 27-42. 10.1002/emmm.2013035032013
Norling LV and Dalli J (2013). Microparticles are novel effectors of immunity. Curr Opin Pharmacol vol. 13, (4) 570-575. 10.1016/j.coph.2013.05.008Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219. 10.1074/mcp.M113.028589Norling LV and Perretti M (2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol vol. 13, (3) 476-481. 10.1016/j.coph.2013.02.003Norling LV and Perretti M (2013). Control of myeloid cell trafficking in resolution. J Innate Immun vol. 5, (4) 367-376. 10.1159/0003506122012
Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M and Cadavid A (2012). Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids vol. 87, (4-5) 127-134. 10.1016/j.plefa.2012.08.003Yazid S, Norling LV and Flower RJ (2012). Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system. Prostaglandins Other Lipid Mediat vol. 98, (3-4) 94-100. 10.1016/j.prostaglandins.2011.11.005Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol vol. 32, (8) 1970-1978. 10.1161/ATVBAHA.112.2495082011
Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. Journal of Immunology vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J Immunol vol. 186, (10) 5543-5547. 10.4049/jimmunol.10038652010
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918. 10.3892/ijmm_00000542Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918. 10.3892/ijmm_00000542Norling LV and Serhan CN (2010). Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med vol. 268, (1) 15-24. 10.1111/j.1365-2796.2010.02235.xNorling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. Faseb Journal vol. 24, 2009
Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature vol. 461, (7268) 1287-U125. 10.1038/nature08541Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukocyte Biol vol. 86, (1) 115-122. 10.1189/JLB.0508284Norling LV, Perretti M and Cooper D (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol vol. 201, (2) 169-184. 10.1677/JOE-08-05122008
Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood vol. 112, (6) 2512-2519. 10.1182/blood-2008-02-140533Cooper D, Norling LV and Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukocyte Biol vol. 83, (6) 1459-1466. 10.1189/jlb.1207831Norling LV, Sampaio ALF, Cooper D and Perretti M (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. Faseb J vol. 22, (3) 682-690. 10.1096/fj.07-9268com2007
Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ and Mitchell JA (2007). Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATP. Mol Pharmacol vol. 72, (5) 1132-1136. 10.1124/mol.107.037325Grants
Grants of specific relevance to Predictive in vitro Models
Reprogramming Resolution in the Arthritic JointNorling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)
Characterisation of Extracellular Vesicles in OsteoarthritisNorling L and Cooper D
£95,000 Centre for Osteoarthritis Pathogenesis Versus Arthritis/Centre for Innovation and Therapeutic Innovation (CiTI) Doctoral Training Programme. (01-04-2020 - 31-03-2023)
Marie Sklodowska-Curie Doctoral Training Progamme ‘‘Arthritis Heal’Norling L and Perretti M
£280,000 European Union’s Horizon 2020 Research and Innovation programme (01-10-2019 - 30-09-2022)
Joint protective actions of omega-3 derived lipid mediatorsNorling L
£230,000 Barts Charity (01-04-2019 - 31-03-2022)
Harnessing the anti-inflammatory properties of neutrophil-derived microvesiclesCooper D and Norling L
£138,798 Versus Arthritis (02-07-2018 - 31-12-2021)
Investigating the role of omega-3 derived resolvins in inflammatory arthritisNorling L
£334,897 Arthritis Research UK (01-05-2012 - 01-09-2018)