Publications
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Publications of specific relevance to Predictive in vitro Models
2023
Norling LV and Cooper D (2023).
Being old and female is an inflammatory combination. Oxford University Press (Oup) Journal of Leukocyte Biology vol. 114, (4) 299-300.
10.1093/jleuko/qiad077
Norling LV, Headland SE,
Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and
Perretti M (2023).
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society For Clinical Investigation Jci Insight vol. 8, (3)
10.1172/jci.insight.168728
Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA,
Norling LV, Thiemermann C and
Perretti M (2023).
Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. Karger Publishers Journal of Innate Immunity vol. 15, (1) 548-561.
10.1159/0005302842022
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Qin CX,
Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C,
Perretti M and Ritchie RH (2022).
Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. Wiley British Journal of Pharmacology vol. 179, (19) 4617-4639.
10.1111/bph.15919![](/publications/bullet24.png)
Oggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P,
Norling LV,
Perretti M and Gupta A (2022).
Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Wolters Kluwer Journal of Hypertension vol. 40, (8) 1522-1529.
10.1097/hjh.0000000000003178![](/publications/bullet24.png)
Cecconello C, Ribas PC and
Norling LV (2022).
Chapter 4 Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line? Diet, Inflammation, and Health Elsevier 10.1016/b978-0-12-822130-3.00018-12021
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Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin‐Williams SN, Voisin M, Hussain MT, Law HL, Niki T, Hirashima M, Bombardieri M, Pitzalis C, Tiwari A, Nash GB,
Norling LV and Cooper D (2021).
Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. Wiley The Faseb Journal vol. 36, (1)
10.1096/fj.202100832r
Chen J,
Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C,
Perretti M and Cooper D (2021).
Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 118, (38)
10.1073/pnas.2020385118![](/publications/bullet24.png)
Austin-Williams S, Hussain MT, Oggero S and
Norling LV (2021).
Enhancing Extracellular Vesicles for therapeutic treatment of arthritic joints. Elsevier Free Radical Biology and Medicine vol. 175, 80-94.
10.1016/j.freeradbiomed.2021.08.235![](/publications/bullet24.png)
Chen J,
Norling LV and Cooper D (2021).
Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation. Mdpi Cells vol. 10, (4)
10.3390/cells10040881![](/publications/bullet24.png)
Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D, Montero‐Melendez T, Cooper D, Burgoyne T, Belton O,
Norling LV, Brennan EP, Godson C and
Perretti M (2021).
Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. Wiley Journal of Extracellular Vesicles vol. 10, (6)
10.1002/jev2.120842020
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Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J,
Norling LV,
Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M and Ioan-Facsinay A (2020).
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid. The American Association of Immunologists The Journal of Immunology vol. 205, (10) 2840-2849.
10.4049/jimmunol.1801653![](/publications/bullet24.png)
Souza PR, Walker ME, Goulding NJ,
Dalli J,
Perretti M and
Norling LV (2020).
The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. Frontiers Media Frontiers in Immunology vol. 11, 573019-573019.
10.3389/fimmu.2020.573019![](/publications/bullet24.png)
Hussain MT, Iqbal AJ and
Norling LV (2020).
The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity. Mdpi International Journal of Molecular Sciences vol. 21, (19)
10.3390/ijms21197096
Norling LV and
Perretti M (2020).
Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 117, (17) 9148-9150.
10.1073/pnas.2004241117
Norling L, Cooper D,
Law H, Wright R and Iqbal A (2020).
A pro-resolving role for Galectin-1 in acute inflammation. Frontiers Media Frontiers in Pharmacology vol. 11, (274)
10.3389/fphar.2020.00274![](/publications/bullet24.png)
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C,
Law HL,
Perretti M,
Norling LV, Azevedo HS and Nissim A (2020).
Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media Frontiers in Immunology vol. 11,
10.3389/fimmu.2020.00010![](/publications/bullet24.png)
Padovan MG and
Norling LV (2020).
Pro-resolving lipid mediators in sepsis and critical illness. Ovid Technologies (Wolters Kluwer Health) Current Opinion in Clinical Nutrition and Metabolic Care 1-1.
10.1097/mco.00000000000006332019
Oggero S, Austin-Williams S and
Norling LV (2019).
The contrasting role of extracellular vesicles in vascular inflammation and tissue repair. Frontiers Media Frontiers in Pharmacology vol. 10,
10.3389/fphar.2019.014792018
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Rhys HI, Dell'Accio F, Pitzalis C, Moore A,
Norling LV and
Perretti M (2018).
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Ebiomedicine vol. 29, 60-69.
10.1016/j.ebiom.2018.02.003![](/publications/bullet24.png)
Oggero S,
Norling L and
Perretti M (2018).
Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases? Japanese Pharmacological Society Proceedings For Annual Meeting of The Japanese Pharmacological Society vol. WCP2018,
10.1254/jpssuppl.wcp2018.0_po1-2-712017
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Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP,
Norling LV, Cooper D, Headland S, Souza PRPS and
Perretti M (2017).
Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Elsevier Journal of Ethnopharmacology vol. 204, 179-188.
10.1016/j.jep.2017.03.059![](/publications/bullet24.png)
Souza PR, Jones HR and
Norling LV (2017).
Novel immunoregulatory mediators produced from omega-3 fatty acids. Nutrition, Immunity, and Infection 10.1201/97813151189012016
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Wright RD, Souza PR, Flak MB, Thedchanamoorthy P,
Norling LV and Cooper D (2016).
Galectin-3-null mice display defective neutrophil clearance during acute inflammation., Editors: Montaner LJ.
The Society For Leukocyte Biology J Leukoc Biol 10.1189/jlb.3A0116-026RR![](/publications/bullet24.png)
Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD,
Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL and Clark AR (2016).
Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. Bmj Annals of The Rheumatic Diseases vol. 76, (3)
10.1136/annrheumdis-2016-209424![](/publications/bullet24.png)
Arnardottir HH,
Dalli J,
Norling LV, Colas RA,
Perretti M and Serhan CN (2016).
Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists Journal of Immunology vol. 197, (6) 2362-2368.
10.4049/jimmunol.1502268![](/publications/bullet24.png)
Souza PR and
Norling LV (2016).
Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. European Journal of Pharmacology vol. 785, 165-173.
10.1016/j.ejphar.2015.05.072
Norling LV, Headland SE,
Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and
Perretti M (2016).
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society For Clinical Investigation Jci Insight vol. 1, (5)
10.1172/jci.insight.859222015
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Headland SE, Jones HR,
Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY and
Perretti M (2015).
Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. American Association For The Advancement of Science (Aaas) Science Translational Medicine vol. 7, (315)
10.1126/scitranslmed.aac5608![](/publications/bullet24.png)
Canova DF, Pavlov AM,
Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and
Perretti M (2015).
Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Elsevier Journal of Controlled Release vol. 217, 284-292.
10.1016/j.jconrel.2015.09.021![](/publications/bullet24.png)
Headland S,
Norling L, Kim A, Jones H, Jan L and Perretti M (2015).
Neutrophil‐Derived Microvesicles Migrate into Cell‐Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis. Wiley The Faseb Journal vol. 29, (S1)
10.1096/fasebj.29.1_supplement.285.112014
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Burgmaier M, Schutters K, Willems B, van der Vorst EP, Kusters D, Chatrou M,
Norling L, Biessen EA, Cleutjens J,
Perretti M, Schurgers LJ and Reutelingsperger CP (2014).
AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE−/− mice. Wiley Journal of Cellular and Molecular Medicine vol. 18, (10) 2117-2124.
10.1111/jcmm.12374![](/publications/bullet24.png)
Montero-Melendez T, Madeira MFM,
Norling LV, Alsam A, Curtis MA, da Silva TA and
Perretti M (2014).
Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol vol. 184, (8) 2333-2341.
10.1016/j.ajpath.2014.04.009![](/publications/bullet24.png)
Headland SE, Jones HR, D'Sa ASV,
Perretti M and
Norling LV (2014).
Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep vol. 4,
10.1038/srep05237
Dalli J,
Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and
Perretti M (2014).
Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. Embo Mol Med vol. 6, (1) 27-42.
10.1002/emmm.2013035032013
Dalli J, Montero-Melendez T,
Norling LV, Yin X, Hinds C, Haskard D, Mayr M and
Perretti M (2013).
Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219.
10.1074/mcp.M113.0285892012
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Gil-Villa AM,
Norling LV, Serhan CN, Cordero D, Rojas M and Cadavid A (2012).
Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids vol. 87, (4-5) 127-134.
10.1016/j.plefa.2012.08.0032011
Norling LV, Spite M, Yang R, Flower RJ,
Perretti M and Serhan CN (2011).
Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol vol. 186, (10) 5543-5547.
10.4049/jimmunol.1003865
Norling LV, Spite M, Yang R, Flower RJ,
Perretti M and Serhan CN (2011).
Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J Immunol vol. 186, (10) 5543-5547.
10.4049/jimmunol.10038652010
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Canaider S, Vettraino M,
Norling LV, Spisni E, Facchin F, Cooper D and
Perretti M (2010).
Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918.
10.3892/ijmm_00000542![](/publications/bullet24.png)
Canaider S, Vettraino M,
Norling LV, Spisni E, Facchin F, Cooper D and
Perretti M (2010).
Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918.
10.3892/ijmm_00000542
Norling LV and Serhan CN (2010).
Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med vol. 268, (1) 15-24.
10.1111/j.1365-2796.2010.02235.x
Norling LV,
Dalli J, Flower RJ, Serhan CN and Perretti M (2010).
Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. Faseb Journal vol. 24,
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Canaider S, Vettraino M,
Norling LV, Spisni E, Facchin F, Cooper D and
Perretti M (2010).
Human RCAN3 gene expression and cell growth in endothelial cells. International Journal of Molecular Medicine vol. 26, (6) 913-918.
10.3892/ijmm_000005422009
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Spite M,
Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ,
Perretti M and Serhan CN (2009).
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature vol. 461, (7268) 1287-1291.
10.1038/nature08541![](/publications/bullet24.png)
Piqueras L, Sanz MJ,
Perretti M, Morcillo E,
Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009).
Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukocyte Biol vol. 86, (1) 115-122.
10.1189/JLB.05082842008
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Cooper D,
Norling LV and
Perretti M (2008).
Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol vol. 83, (6) 1459-1466.
10.1189/jlb.12078312007
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Harrington LS, Evans RJ, Wray J,
Norling L, Swales KE, Vial C, Ali F, Carrier MJ and Mitchell JA (2007).
Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATP. Mol Pharmacol vol. 72, (5) 1132-1136.
10.1124/mol.107.037325