Dr Lucy Norling

Lucy Norling

Versus Arthritis Senior Fellow
CPM ECR Mentoring, Social Media and Public Engagement Lead

Centre for Biochemical Pharmacology
Faculty of Medicine and Dentistry, Queen Mary University of London
www.qmul.ac.uk/whri/people/academic-staff/items/norlinglucy.html
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Research

Musculoskeletal, Leukocyte Trafficking, Omega-3, Chemotaxis

Infectious Disease and Inflammation Models, Musculoskeletal Models

Interests

My research group is interested in how omega-3 derived lipid mediators can protect and repair joint tissues. I have a keen interest in the development of human in vitro models to mimic various aspects of the inflammatory response including leukocyte-endothelial interactions, cell chemotaxis, phagocytosis and efferocytosis as well as the development of musculoskeletal models.

Publications

Publications of specific relevance to Predictive in vitro Models

2022

Oggero S, Godec T, van Gorp R, Pinto LA, Schurgers JL, Reutelingsperger C, Sever P, Norling LV, Perretti M and Gupta A (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Journal of Hypertension  vol. 40, (8) 1522-1529. 10.1097/HJH.0000000000003178
Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin-Williams SN, Voisin MB, Hussain MT, Law HL, Niki T, Hirashima M, Bombardieri M, Pitzalis C, Tiwari A, Nash GB, Norling LV and Cooper D (2022). Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner. Faseb Journal  vol. 36, (1) 10.1096/fj.202100832R
Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M and Ritchie RH (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. British Journal of Pharmacology  10.1111/bph.15919

2021

Austin-Williams S, Hussain MT, Oggero S and Norling LV (2021). Enhancing Extracellular Vesicles for therapeutic treatment of arthritic joints. Free Radical Biology and Medicine  vol. 175, 80-94. 10.1016/j.freeradbiomed.2021.08.235
Chen J, Norling LV, Mesa JG, de Paula Silva M, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of The National Academy of Sciences of The United States of America  vol. 118, (38) 10.1073/pnas.2020385118
Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D, Montero-Melendez T, Cooper D, Burgoyne T, Belton O, Norling LV, Brennan EP, Godson C and Perretti M (2021). Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. Journal of Extracellular Vesicles  vol. 10, (6) 10.1002/jev2.12084
Chen J, Norling LV and Cooper D (2021). Cardiac dysfunction in rheumatoid arthritis: The role of inflammation. Cells  vol. 10, (4) 10.3390/cells10040881

2020

Brouwers H, Jonasdottir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, Lopez-Vicario C, Claria J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M and Ioan-Facsinay A (2020). Anti-inflammatory and proresolving effects of the omega-6 polyunsaturated fatty acid adrenic acid. Journal of Immunology  vol. 205, (10) 2840-2849. 10.4049/jimmunol.1801653
Hussain MT, Iqbal AJ and Norling LV (2020). The role and impact of extracellular vesicles in the modulation and delivery of cytokines during autoimmunity. International Journal of Molecular Sciences  vol. 21, (19) 1-18. 10.3390/ijms21197096
Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M and Norling LV (2020). The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. Frontiers Media  Frontiers in Immunology  vol. 11, 573019-573019. 10.3389/fimmu.2020.573019
Norling LV and Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of The National Academy of Sciences of The United States of America  vol. 117, (17) 9148-9150. 10.1073/pnas.2004241117
Norling L, Cooper D, Law H, Wright R and Iqbal A (2020). A pro-resolving role for Galectin-1 in acute inflammation. Frontiers Media  Frontiers in Pharmacology  vol. 11, (274) 10.3389/fphar.2020.00274
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media  Frontiers in Immunology  vol. 11, 10.3389/fimmu.2020.00010
Padovan MG and Norling LV (2020). Pro-resolving lipid mediators in sepsis and critical illness. Ovid Technologies (Wolters Kluwer Health)  Current Opinion in Clinical Nutrition and Metabolic Care  1-1. 10.1097/mco.0000000000000633

2019

Oggero S, Austin-Williams S and Norling LV (2019). The contrasting role of extracellular vesicles in vascular inflammation and tissue repair. Frontiers Media  Frontiers in Pharmacology  vol. 10, 10.3389/fphar.2019.01479

2018

Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV and Perretti M (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Ebiomedicine  vol. 29, 60-69. 10.1016/j.ebiom.2018.02.003
Oggero S, Norling L and Perretti M (2018). Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases? Proceedings For Annual Meeting of The Japanese Pharmacological Society  vol. WCP2018, 10.1254/jpssuppl.wcp2018.0_po1-2-71

2017

Perretti M and Norling LV (2017). Actions of SPM in regulating host responses in arthritis. Molecular Aspects of Medicine  vol. 58, 57-64. 10.1016/j.mam.2017.04.005
Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Journal of Ethnopharmacology  vol. 204, 179-188. 10.1016/j.jep.2017.03.059
Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL and Clark AR (2017). Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. Annals of The Rheumatic Diseases  vol. 76, (3) 612-619. 10.1136/annrheumdis-2016-209424
Norling LV, Ly L and Dalli J (2017). Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care  vol. 20, (2) 145-152. 10.1097/MCO.0000000000000353
Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol  vol. 13, (2) 87-99. 10.1038/nrrheum.2016.193
Souza PR, Jones HR and Norling LV (2017). Novel immunoregulatory mediators produced from omega-3 fatty acids. Nutrition, Immunity, and Infection  10.1201/9781315118901

2016

Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV and Cooper D (2016). Galectin-3-null mice display defective neutrophil clearance during acute inflammation., Editors: Montaner LJ. The Society For Leukocyte Biology  J Leukoc Biol  10.1189/jlb.3A0116-026RR
Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists  Journal of Immunology  vol. 197, (6) 2362-2368. 10.4049/jimmunol.1502268
Souza PR and Norling LV (2016). Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. European Journal of Pharmacology  vol. 785, 165-173. 10.1016/j.ejphar.2015.05.072
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. Jci Insight  vol. 1, (5) 10.1172/jci.insight.85922

2015

Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'accio F, Pitzalis C, Oliani SM, Jan LY and Perretti M (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Science Translational Medicine  vol. 7, (315) 10.1126/scitranslmed.aac5608
Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Journal of Controlled Release  vol. 217, 284-292. 10.1016/j.jconrel.2015.09.021
Headland SE and Norling LV (2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology  vol. 27, (3) 149-160. 10.1016/j.smim.2015.03.014
Headland S, Norling L, Kim A, Jones H, Jan L and Perretti M (2015). Neutrophil‐Derived Microvesicles Migrate into Cell‐Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis. The Faseb Journal  vol. 29, (S1) 10.1096/fasebj.29.1_supplement.285.11
Headland SE and Norling LV (2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology  10.1016/j.smim.2015.03.014

2014

Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine  vol. 18, (10) 2117-2124. 10.1111/jcmm.12374
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol  vol. 184, (8) 2333-2341. 10.1016/j.ajpath.2014.04.009
Cash JL, Norling LV and Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today  vol. 19, (8) 1186-1192. 10.1016/j.drudis.2014.06.023
Headland SE, Jones HR, D'Sa ASV, Perretti M and Norling LV (2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep  vol. 4, 10.1038/srep05237
Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. Embo Mol Med  vol. 6, (1) 27-42. 10.1002/emmm.201303503

2013

Norling LV and Dalli J (2013). Microparticles are novel effectors of immunity. Curr Opin Pharmacol  vol. 13, (4) 570-575. 10.1016/j.coph.2013.05.008
Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics  vol. 12, (8) 2205-2219. 10.1074/mcp.M113.028589
Norling LV and Perretti M (2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol  vol. 13, (3) 476-481. 10.1016/j.coph.2013.02.003
Norling LV and Perretti M (2013). Control of myeloid cell trafficking in resolution. J Innate Immun  vol. 5, (4) 367-376. 10.1159/000350612

2012

Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M and Cadavid A (2012). Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids  vol. 87, (4-5) 127-134. 10.1016/j.plefa.2012.08.003
Yazid S, Norling LV and Flower RJ (2012). Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system. Prostaglandins Other Lipid Mediat  vol. 98, (3-4) 94-100. 10.1016/j.prostaglandins.2011.11.005
Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol  vol. 32, (8) 1970-1978. 10.1161/ATVBAHA.112.249508

2011

Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. Journal of Immunology  vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865
Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J Immunol  vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865

2010

Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med  vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med  vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Norling LV and Serhan CN (2010). Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med  vol. 268, (1) 15-24. 10.1111/j.1365-2796.2010.02235.x
Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. Faseb Journal  vol. 24,
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. International Journal of Molecular Medicine  vol. 26, (6) 913-918. 10.3892/ijmm_00000542

2009

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature  vol. 461, (7268) 1287-U125. 10.1038/nature08541
Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukocyte Biol  vol. 86, (1) 115-122. 10.1189/JLB.0508284
Norling LV, Perretti M and Cooper D (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol  vol. 201, (2) 169-184. 10.1677/JOE-08-0512

2008

Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood  vol. 112, (6) 2512-2519. 10.1182/blood-2008-02-140533
Cooper D, Norling LV and Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukocyte Biol  vol. 83, (6) 1459-1466. 10.1189/jlb.1207831
Norling LV, Sampaio ALF, Cooper D and Perretti M (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. Faseb J  vol. 22, (3) 682-690. 10.1096/fj.07-9268com

2007

Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ and Mitchell JA (2007). Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATP. Mol Pharmacol  vol. 72, (5) 1132-1136. 10.1124/mol.107.037325

Grants

Grants of specific relevance to Predictive in vitro Models
Reprogramming Resolution in the Arthritic Joint
Norling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)
Characterisation of Extracellular Vesicles in Osteoarthritis
Norling L and Cooper D
£95,000 Centre for Osteoarthritis Pathogenesis Versus Arthritis/Centre for Innovation and Therapeutic Innovation (CiTI) Doctoral Training Programme. (01-04-2020 - 31-03-2023)
Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis
Perretti M and Norling L
£230,000 EU (01-03-2019 - 28-02-2023)
Summary
Cardiomyopathy in RA
Perretti M, Norling L, Cooper D and Chen J
£230,000 Bristol-Myers Squibb (01-06-2021 - 30-11-2022)
Summary
Marie Sklodowska-Curie Doctoral Training Progamme ‘‘Arthritis Heal’
Norling L and Perretti M
£280,000 European Union’s Horizon 2020 Research and Innovation programme (01-10-2019 - 30-09-2022)

Joint protective actions of omega-3 derived lipid mediators
Norling L
£230,000 Barts Charity (01-04-2019 - 31-03-2022)
Harnessing the anti-inflammatory properties of neutrophil-derived microvesicles
Cooper D and Norling L
£138,798 Versus Arthritis (02-07-2018 - 31-12-2021)
Investigating the role of omega-3 derived resolvins in inflammatory arthritis
Norling L
£334,897 Arthritis Research UK (01-05-2012 - 01-09-2018)
Summary