Dr Lucy Norling
Versus Arthritis Senior Fellow
CPM ECR Mentoring, Social Media and Public Engagement Lead
Centre for Biochemical Pharmacology
Faculty of Medicine and Dentistry, Queen Mary University of London
Faculty of Medicine and Dentistry, Queen Mary University of London
Research
Musculoskeletal, joint-on-a-chip, Omega-3 lipid mediators, Inflammation resolution, Extracellular vesicles, Leukocyte Trafficking
Interests
My research group is interested in how omega-3 derived lipid mediators can protect and repair joint tissues. I have a keen interest in the development of human in vitro models to mimic various aspects of the inflammatory response including leukocyte-endothelial interactions, cell chemotaxis, phagocytosis and efferocytosis as well as the development of musculoskeletal models.Publications
2023
Norling LV and Cooper D (2023). Being old and female is an inflammatory combination. Oxford University Press (Oup) Journal of Leukocyte Biology vol. 114, (4) 299-300. 10.1093/jleuko/qiad077
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2023). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society For Clinical Investigation Jci Insight vol. 8, (3) 10.1172/jci.insight.168728
Chen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C and Perretti M (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. Karger Publishers Journal of Innate Immunity vol. 15, (1) 548-561. 10.1159/000530284
2022
Norling LV and Halade GV (2022). Helpful inflammation turned harmful in non-communicable diseases. Elsevier Current Opinion in Pharmacology vol. 67, 10.1016/j.coph.2022.102317
Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M and Ritchie RH (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. Wiley British Journal of Pharmacology vol. 179, (19) 4617-4639. 10.1111/bph.15919
Oggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P, Norling LV, Perretti M and Gupta A (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Wolters Kluwer Journal of Hypertension vol. 40, (8) 1522-1529. 10.1097/hjh.0000000000003178
Cecconello C, Ribas PC and Norling LV (2022). Chapter 4 Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line? Diet, Inflammation, and Health Elsevier 10.1016/b978-0-12-822130-3.00018-1
2021
Iqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin‐Williams SN, Voisin M, Hussain MT, Law HL, Niki T, Hirashima M, Bombardieri M, Pitzalis C, Tiwari A, Nash GB, Norling LV and Cooper D (2021). Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. Wiley The Faseb Journal vol. 36, (1) 10.1096/fj.202100832r
Chen J, Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 118, (38) 10.1073/pnas.2020385118
Austin-Williams S, Hussain MT, Oggero S and Norling LV (2021). Enhancing Extracellular Vesicles for therapeutic treatment of arthritic joints. Elsevier Free Radical Biology and Medicine vol. 175, 80-94. 10.1016/j.freeradbiomed.2021.08.235
Chen J, Norling LV and Cooper D (2021). Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation. Mdpi Cells vol. 10, (4) 10.3390/cells10040881
Oggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D, Montero‐Melendez T, Cooper D, Burgoyne T, Belton O, Norling LV, Brennan EP, Godson C and Perretti M (2021). Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. Wiley Journal of Extracellular Vesicles vol. 10, (6) 10.1002/jev2.12084
2020
Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M and Ioan-Facsinay A (2020). Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid. The American Association of Immunologists The Journal of Immunology vol. 205, (10) 2840-2849. 10.4049/jimmunol.1801653
Souza PR, Walker ME, Goulding NJ, Dalli J, Perretti M and Norling LV (2020). The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. Frontiers Media Frontiers in Immunology vol. 11, 573019-573019. 10.3389/fimmu.2020.573019
Hussain MT, Iqbal AJ and Norling LV (2020). The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity. Mdpi International Journal of Molecular Sciences vol. 21, (19) 10.3390/ijms21197096
Norling LV and Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 117, (17) 9148-9150. 10.1073/pnas.2004241117
Norling L, Cooper D, Law H, Wright R and Iqbal A (2020). A pro-resolving role for Galectin-1 in acute inflammation. Frontiers Media Frontiers in Pharmacology vol. 11, (274) 10.3389/fphar.2020.00274
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media Frontiers in Immunology vol. 11, 10.3389/fimmu.2020.00010
Padovan MG and Norling LV (2020). Pro-resolving lipid mediators in sepsis and critical illness. Ovid Technologies (Wolters Kluwer Health) Current Opinion in Clinical Nutrition and Metabolic Care 1-1. 10.1097/mco.0000000000000633
2019
Oggero S, Austin-Williams S and Norling LV (2019). The contrasting role of extracellular vesicles in vascular inflammation and tissue repair. Frontiers Media Frontiers in Pharmacology vol. 10, 10.3389/fphar.2019.01479
2018
Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV and Perretti M (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Ebiomedicine vol. 29, 60-69. 10.1016/j.ebiom.2018.02.003
Oggero S, Norling L and Perretti M (2018). Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases? Japanese Pharmacological Society Proceedings For Annual Meeting of The Japanese Pharmacological Society vol. WCP2018, 10.1254/jpssuppl.wcp2018.0_po1-2-71
2017
Perretti M and Norling LV (2017). Actions of SPM in regulating host responses in arthritis. Elsevier Molecular Aspects of Medicine vol. 58, 57-64. 10.1016/j.mam.2017.04.005
Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Elsevier Journal of Ethnopharmacology vol. 204, 179-188. 10.1016/j.jep.2017.03.059
Norling LV, Ly L and Dalli J (2017). Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care vol. 20, (2) 145-152. 10.1097/MCO.0000000000000353
Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol vol. 13, (2) 87-99. 10.1038/nrrheum.2016.193
Souza PR, Jones HR and Norling LV (2017). Novel immunoregulatory mediators produced from omega-3 fatty acids. Nutrition, Immunity, and Infection 10.1201/9781315118901
2016
Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV and Cooper D (2016). Galectin-3-null mice display defective neutrophil clearance during acute inflammation., Editors: Montaner LJ. The Society For Leukocyte Biology J Leukoc Biol 10.1189/jlb.3A0116-026RR
Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL and Clark AR (2016). Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. Bmj Annals of The Rheumatic Diseases vol. 76, (3) 10.1136/annrheumdis-2016-209424
Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists Journal of Immunology vol. 197, (6) 2362-2368. 10.4049/jimmunol.1502268
Souza PR and Norling LV (2016). Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. European Journal of Pharmacology vol. 785, 165-173. 10.1016/j.ejphar.2015.05.072
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. American Society For Clinical Investigation Jci Insight vol. 1, (5) 10.1172/jci.insight.85922
2015
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY and Perretti M (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. American Association For The Advancement of Science (Aaas) Science Translational Medicine vol. 7, (315) 10.1126/scitranslmed.aac5608
Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Elsevier Journal of Controlled Release vol. 217, 284-292. 10.1016/j.jconrel.2015.09.021
Headland SE and Norling LV (2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology vol. 27, (3) 149-160. 10.1016/j.smim.2015.03.014
Headland S, Norling L, Kim A, Jones H, Jan L and Perretti M (2015). Neutrophil‐Derived Microvesicles Migrate into Cell‐Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis. Wiley The Faseb Journal vol. 29, (S1) 10.1096/fasebj.29.1_supplement.285.11
2014
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol vol. 184, (8) 2333-2341. 10.1016/j.ajpath.2014.04.009
Cash JL, Norling LV and Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today vol. 19, (8) 1186-1192. 10.1016/j.drudis.2014.06.023
Headland SE, Jones HR, D'Sa ASV, Perretti M and Norling LV (2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep vol. 4, 10.1038/srep05237
Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. Embo Mol Med vol. 6, (1) 27-42. 10.1002/emmm.201303503
Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE-/- mice. Journal of Cellular and Molecular Medicine vol. 18, (10) 2117-2124. 10.1111/jcmm.12374
2013
Norling LV and Dalli J (2013). Microparticles are novel effectors of immunity. Curr Opin Pharmacol vol. 13, (4) 570-575. 10.1016/j.coph.2013.05.008
Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics vol. 12, (8) 2205-2219. 10.1074/mcp.M113.028589
Norling LV and Perretti M (2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol vol. 13, (3) 476-481. 10.1016/j.coph.2013.02.003
Norling LV and Perretti M (2013). Control of myeloid cell trafficking in resolution. J Innate Immun vol. 5, (4) 367-376. 10.1159/000350612
2012
Yazid S, Norling LV and Flower RJ (2012). Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system. Prostaglandins Other Lipid Mediat vol. 98, (3-4) 94-100. 10.1016/j.prostaglandins.2011.11.005
Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol vol. 32, (8) 1970-1978. 10.1161/ATVBAHA.112.249508
Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M and Cadavid A (2012). Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids vol. 87, (4-5) 127-134. 10.1016/j.plefa.2012.08.003
2011
Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865
Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J Immunol vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865
2010
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Spandidos Publications International Journal of Molecular Medicine vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Norling LV and Serhan CN (2010). Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med vol. 268, (1) 15-24. 10.1111/j.1365-2796.2010.02235.x
Ayoub SS, Norling LV, Leoni G, Cooper D and Perretti M (2010). Cell Adhesion Molecules. Fundamentals of Inflammation Cambridge University Press (Cup) 10.1017/cbo9781139195737.018
Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. Faseb Journal vol. 24,
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. International Journal of Molecular Medicine vol. 26, (6) 913-918. 10.3892/ijmm_00000542
2009
Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature vol. 461, (7268) 1287-U125. 10.1038/nature08541
Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukocyte Biol vol. 86, (1) 115-122. 10.1189/JLB.0508284
Norling LV, Perretti M and Cooper D (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol vol. 201, (2) 169-184. 10.1677/JOE-08-0512
2008
Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood vol. 112, (6) 2512-2519. 10.1182/blood-2008-02-140533
Cooper D, Norling LV and Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukocyte Biol vol. 83, (6) 1459-1466. 10.1189/jlb.1207831
Norling LV, Sampaio ALF, Cooper D and Perretti M (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. Faseb J vol. 22, (3) 682-690. 10.1096/fj.07-9268com
2007
Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ and Mitchell JA (2007). Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATP. Mol Pharmacol vol. 72, (5) 1132-1136. 10.1124/mol.107.037325
Grants
Grants of specific relevance to Predictive in vitro Models
Reprogramming Resolution in the Arthritic Joint
Norling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)
Norling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)
Characterisation of Extracellular Vesicles in Osteoarthritis
Norling L and Cooper D
£95,000 Centre for Osteoarthritis Pathogenesis Versus Arthritis/Centre for Innovation and Therapeutic Innovation (CiTI) Doctoral Training Programme. (01-04-2020 - 31-03-2023)
Norling L and Cooper D
£95,000 Centre for Osteoarthritis Pathogenesis Versus Arthritis/Centre for Innovation and Therapeutic Innovation (CiTI) Doctoral Training Programme. (01-04-2020 - 31-03-2023)
Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis
Perretti M and Norling L
£230,000 EU (01-03-2019 - 28-02-2023)
Perretti M and Norling L
£230,000 EU (01-03-2019 - 28-02-2023)
Cardiomyopathy in RA
Perretti M, Norling L, Cooper D and Chen J
£230,000 Bristol-Myers Squibb (01-06-2021 - 30-11-2022)
Perretti M, Norling L, Cooper D and Chen J
£230,000 Bristol-Myers Squibb (01-06-2021 - 30-11-2022)
Marie Sklodowska-Curie Doctoral Training Progamme ‘‘Arthritis Heal’
Norling L and Perretti M
£280,000 European Union’s Horizon 2020 Research and Innovation programme (01-10-2019 - 30-09-2022)
Norling L and Perretti M
£280,000 European Union’s Horizon 2020 Research and Innovation programme (01-10-2019 - 30-09-2022)
Joint protective actions of omega-3 derived lipid mediators
Norling L
£230,000 Barts Charity (01-04-2019 - 31-03-2022)
Norling L
£230,000 Barts Charity (01-04-2019 - 31-03-2022)
Harnessing the anti-inflammatory properties of neutrophil-derived microvesicles
Cooper D and Norling L
£138,798 Versus Arthritis (02-07-2018 - 31-12-2021)
Cooper D and Norling L
£138,798 Versus Arthritis (02-07-2018 - 31-12-2021)
Investigating the role of omega-3 derived resolvins in inflammatory arthritis
Norling L
£334,897 Arthritis Research UK (01-05-2012 - 01-09-2018)
Norling L
£334,897 Arthritis Research UK (01-05-2012 - 01-09-2018)