Dr Lucy Norling
Versus Arthritis Senior Fellow
CPM Lead for ECR Engagement
Centre for Biochemical Pharmacology
Queen Mary University of London
Queen Mary University of London
Research
Musculoskeletal, joint-on-a-chip, Omega-3 lipid mediators, Inflammation resolution, Extracellular vesicles, Leukocyte Trafficking
Interests
My research group is interested in how omega-3 derived lipid mediators can protect and repair joint tissues. I have a keen interest in the development of human in vitro models to mimic various aspects of the inflammatory response including leukocyte-endothelial interactions, cell chemotaxis, phagocytosis and efferocytosis as well as the development of musculoskeletal models.Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2025
Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritisMargraf A, Chen J, Christoforou M, Claria-Ribas P, Henriques Schneider A, Cecconello C, Bu W, Imbert PRC, Wright TD, Russo S, Blacksell IA, Koenis DS, Dalli J, Lupisella JA, Wurtz NR, Garcia RA, Cooper D, Norling LV and Perretti M
Embo Molecular Medicine, Springer Nature, 1-31.
03-04-2025
2024
Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory ArthritisThomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D, Austin‐Williams S, Hussain MT, Pitzalis C, Allen B, Malcangio M, Dell'Accio F, Norling LV and Perretti M
Arthritis & Rheumatology, Wiley vol. 76 (12), 1705-1718.
16-08-2024
β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte HomeostasisHussain MT, Austin-Williams S, Wright TD, Dhawan UK, Pinto AL, Cooper D and Norling LV
International Journal of Molecular Sciences, Mdpi vol. 25 (9)
26-04-2024
2023
Being old and female is an inflammatory combinationNorling LV and Cooper D
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 114 (4), 299-300.
04-07-2023
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritisNorling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M
Jci Insight, American Society For Clinical Investigation vol. 8 (3)
08-02-2023
Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac DysfunctionChen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C and Perretti M
Journal of Innate Immunity, Karger Publishers vol. 15 (1), 548-561.
01-01-2023
2022
Helpful inflammation turned harmful in non-communicable diseasesNorling LV and Halade GV
Current Opinion in Pharmacology, Elsevier vol. 67
08-11-2022
Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35Qin CX, Norling LV, Vecchio EA, Brennan EP, May LT, Wootten D, Godson C, Perretti M and Ritchie RH
British Journal of Pharmacology, Wiley vol. 179 (19), 4617-4639.
29-07-2022
Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patientsOggero S, Godec T, van Gorp R, Pinto AL, Schurgers LJ, Reutelingsperger C, Sever P, Norling LV, Perretti M and Gupta A
Journal of Hypertension, Wolters Kluwer vol. 40 (8), 1522-1529.
21-06-2022
Chapter 4 Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line?Cecconello C, Ribas PC and Norling LV
In Diet, Inflammation, and Health, Elsevier 113-162.
01-01-2022
2021
Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent mannerIqbal AJ, Krautter F, Blacksell IA, Wright RD, Austin‐Williams SN, Voisin M, Hussain MT, Law HL, Niki T, Hirashima M, Bombardieri M, Pitzalis C, Tiwari A, Nash GB, Norling LV and Cooper D
The Faseb Journal, Wiley vol. 36 (1)
30-11-2021
Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritisChen J, Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C, Perretti M and Cooper D
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 118 (38)
15-09-2021
Enhancing Extracellular Vesicles for therapeutic treatment of arthritic jointsAustin-Williams S, Hussain MT, Oggero S and Norling LV
Free Radical Biology and Medicine, Elsevier vol. 175, 80-94.
27-08-2021
Cardiac Dysfunction in Rheumatoid Arthritis: The Role of InflammationChen J, Norling LV and Cooper D
Cells, Mdpi vol. 10 (4)
13-04-2021
Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivityOggero S, de Gaetano M, Marcone S, Fitzsimons S, Pinto AL, Ikramova D, Barry M, Burke D, Montero‐Melendez T, Cooper D, Burgoyne T, Belton O, Norling LV, Brennan EP, Godson C and Perretti M
Journal of Extracellular Vesicles, Wiley vol. 10 (6)
01-04-2021
2020
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid.Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M and Ioan-Facsinay A
The Journal of Immunology, Oxford University Press (Oup) vol. 205 (10), 2840-2849.
15-11-2020
The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli InfectionsSouza PR, Walker ME, Goulding NJ, Dalli J, Perretti M and Norling LV
Frontiers in Immunology, Frontiers Media vol. 11, 573019-573019.
29-09-2020
The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during AutoimmunityHussain MT, Iqbal AJ and Norling LV
International Journal of Molecular Sciences, Mdpi vol. 21 (19)
26-09-2020
Proresolving lipid mediators enhance PMN-mediated bacterial clearanceNorling LV and Perretti M
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 117 (17), 9148-9150.
16-04-2020
A pro-resolving role for Galectin-1 in acute inflammationNorling L, Cooper D, Law H, Wright R and Iqbal A
Frontiers in Pharmacology, Frontiers Media vol. 11 (274)
20-03-2020
Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific AntibodyTopping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A
Frontiers in Immunology, Frontiers Media vol. 11
14-02-2020
Pro-resolving lipid mediators in sepsis and critical illnessPadovan MG and Norling LV
Current Opinion in Clinical Nutrition and Metabolic Care, Ovid Technologies (Wolters Kluwer Health), 1-1.
03-01-2020
2019
The contrasting role of extracellular vesicles in vascular inflammation and tissue repairOggero S, Austin-Williams S and Norling LV
Frontiers in Pharmacology, Frontiers Media vol. 10
17-12-2019
2018
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of MacrophagesRhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV and Perretti M
Ebiomedicine, Elsevier vol. 29, 60-69.
07-02-2018
Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases?Oggero S, Norling L and Perretti M
Proceedings For Annual Meeting of The Japanese Pharmacological Society, Japanese Pharmacological Society vol. WCP2018
01-01-2018
2017
Actions of SPM in regulating host responses in arthritisPerretti M and Norling LV
Molecular Aspects of Medicine, Elsevier vol. 58, 57-64.
05-05-2017
Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathwaysPiovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M
Journal of Ethnopharmacology, Elsevier vol. 204, 179-188.
13-04-2017
Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators.Norling LV, Ly L and Dalli J
Curr Opin Clin Nutr Metab Care vol. 20 (2), 145-152.
01-03-2017
Immune resolution mechanisms in inflammatory arthritis.Perretti M, Cooper D, Dalli J and Norling LV
Nat Rev Rheumatol vol. 13 (2), 87-99.
05-01-2017
Novel immunoregulatory mediators produced from omega-3 fatty acidsSouza PR, Jones HR and Norling LV
In Nutrition, Immunity, and Infection 315-334.
01-01-2017
2016
Galectin-3-null mice display defective neutrophil clearance during acute inflammation.Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV and Cooper D
, Editors: Montaner LJ. J Leukoc Biol, The Society For Leukocyte Biology
12-10-2016
Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expressionRoss EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL and Clark AR
Annals of The Rheumatic Diseases, Elsevier vol. 76 (3), 612-619.
05-09-2016
Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation.Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN
Journal of Immunology, American Association of Immunologists vol. 197 (6), 2362-2368.
17-08-2016
Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritisSouza PR and Norling LV
European Journal of Pharmacology vol. 785, 165-173.
09-07-2016
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritisNorling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M
Jci Insight, American Society For Clinical Investigation vol. 1 (5)
21-04-2016
2015
Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritisHeadland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY and Perretti M
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 7 (315)
25-11-2015
Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune responseCanova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M
Journal of Controlled Release, Elsevier vol. 217, 284-292.
16-09-2015
The resolution of inflammation: Principles and challengesHeadland SE and Norling LV
Seminars in Immunology vol. 27 (3), 149-160.
01-05-2015
Neutrophil‐Derived Microvesicles Migrate into Cell‐Impenetrable Cartilage to Protect the Joint During Inflammatory ArthritisHeadland S, Norling L, Kim A, Jones H, Jan L and Perretti M
The Faseb Journal, Wiley vol. 29 (S1)
01-04-2015
2014
Resolution of inflammation: targeting GPCRs that interact with lipids and peptides.Cash JL, Norling LV and Perretti M
Drug Discov Today vol. 19 (8), 1186-1192.
01-08-2014
Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3.Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M
Am J Pathol vol. 184 (8), 2333-2341.
01-08-2014
Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry.Headland SE, Jones HR, D'Sa ASV, Perretti M and Norling LV
Sci Rep vol. 4
10-06-2014
Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis.Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M
Embo Mol Med vol. 6 (1), 27-42.
01-01-2014
AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE-/- miceBurgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM
Journal of Cellular and Molecular Medicine vol. 18 (10), 2117-2124.
01-01-2014
2013
Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties.Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M
Mol Cell Proteomics vol. 12 (8), 2205-2219.
01-08-2013
Microparticles are novel effectors of immunity.Norling LV and Dalli J
Curr Opin Pharmacol vol. 13 (4), 570-575.
01-08-2013
The role of omega-3 derived resolvins in arthritis.Norling LV and Perretti M
Curr Opin Pharmacol vol. 13 (3), 476-481.
01-06-2013
Control of myeloid cell trafficking in resolution.Norling LV and Perretti M
J Innate Immun vol. 5 (4), 367-376.
01-01-2013
2012
Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system.Yazid S, Norling LV and Flower RJ
Prostaglandins Other Lipid Mediat vol. 98 (3-4), 94-100.
01-08-2012
Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M
Arterioscler Thromb Vasc Biol vol. 32 (8), 1970-1978.
01-08-2012
Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma.Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M and Cadavid A
Prostaglandins Leukot Essent Fatty Acids vol. 87 (4-5), 127-134.
01-01-2012
2011
Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN
J Immunol vol. 186 (10), 5543-5547.
15-05-2011
Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound HealingNorling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN
J Immunol vol. 186 (10), 5543-5547.
15-05-2011
2010
Human RCAN3 gene expression and cell growth in endothelial cellsCanaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M
Int J Mol Med vol. 26 (6), 913-918.
01-12-2010
Human RCAN3 gene expression and cell growth in endothelial cells.Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M
International Journal of Molecular Medicine, Spandidos Publications vol. 26 (6), 913-918.
21-10-2010
Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination.Norling LV and Serhan CN
J Intern Med vol. 268 (1), 15-24.
01-07-2010
Cell Adhesion MoleculesAyoub SS, Norling LV, Leoni G, Cooper D and Perretti M
In Fundamentals of Inflammation, Cambridge University Press (Cup) 208-216.
26-04-2010
Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactionsNorling LV, Dalli J, Flower RJ, Serhan CN and Perretti M
Faseb Journal vol. 24
01-04-2010
Human RCAN3 gene expression and cell growth in endothelial cellsCanaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M
International Journal of Molecular Medicine vol. 26 (6), 913-918.
01-01-2010
2009
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsisSpite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN
Nature vol. 461 (7268), 1287-U125.
29-10-2009
Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine releasePiqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D
J Leukocyte Biol vol. 86 (1), 115-122.
01-07-2009
Endogenous galectins and the control of the host inflammatory response.Norling LV, Perretti M and Cooper D
J Endocrinol vol. 201 (2), 169-184.
01-05-2009
2008
Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticlesDalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M
Blood vol. 112 (6), 2512-2519.
15-09-2008
Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flowCooper D, Norling LV and Perretti M
J Leukocyte Biol vol. 83 (6), 1459-1466.
01-06-2008
Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte traffickingNorling LV, Sampaio ALF, Cooper D and Perretti M
Faseb J vol. 22 (3), 682-690.
01-03-2008
2007
Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATPHarrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ and Mitchell JA
Mol Pharmacol vol. 72 (5), 1132-1136.
01-11-2007
Grants
Grants of specific relevance to Predictive in vitro Models
EVs characterization in rheumatoid arthritisElisa Corsiero and Lucy Norling
£72,500 Barts and the London Charity
21-04-2025 - 20-04-2026
CCR7 peptide inhibitor: Therapeutic control of adaptive immunity in health & diseaseMathieu-Benoit Voisin and Lucy Norling
£320,506 Barts and the London Charity
03-03-2025 - 02-03-2028
Validation of novel therapies for the treatment of arthritisLucy Norling
£32,051 WHRL William Harvey Research Limited
01-02-2025 - 31-01-2026
Assessing the pro-resolving and anti-arthritic properties of cannabidiol in chronic inflammationMauro Perretti and Lucy Norling
£130,358 WHRL William Harvey Research Limited
01-10-2024 - 31-03-2026
EPSRC Centre for Doctoral Training in Next Generation Organ-on-a-Chip Technology (COaCT)Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 EPSRC Engineering and Physical Sciences Research Council
Grant Summary
01-07-2024 - 30-09-2032
Melancortins to control cystic fibrosis airway inflammationMauro Perretti, Charles Mein and Lucy Norling
£21,271 Italian Cystic Fibrosis Research Foundation Fondazione Italiana per la ricerca sulla Fibrosi Cistica
01-12-2023 - 30-11-2025
Reprogramming resolution in the arthritic jointLucy Norling
£720,853 Versus Arthritis
01-09-2019 - 30-09-2025
Impact of aging on extracellular vesicle functionDianne Cooper and Lucy Norling
£46,820 DMT Dunhill Medical Trust, The
01-01-2022 - 12-12-2023
WHRF small equipment grant -Norling/CooperLucy Norling and Dianne Cooper
£7,000 WHRF William Harvey Research Foundation
01-07-2021 - 30-06-2022
CardiomyopathyinRAMauro Perretti and Lucy Norling
£230,740 Bristol-Myers Squibb Pharmaceuticals Ltd
01-05-2021 - 31-12-2023
Joint Protective Actions of Omega-3 Derived Lipid MediatorsLucy Norling and Jesmond Dalli
£231,527 Barts and the London Charity
17-04-2021 - 30-11-2023
Flow NanoAnalyzer: a next-generation platform for comprehensive extracellular vesicle analysisLucy Norling and Dianne Cooper
£49,000 Barts and the London Charity
16-03-2020 - 15-03-2021
Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal ArthritisMauro Perretti and Lucy Norling
£225,258 EU Commission - Horizon 2020
01-03-2019 - 28-02-2023
Harnessing the chondroprotective effects of microvesiclesDianne Cooper and Lucy Norling
£151,383 AR-UK Versus Arthritis
02-07-2018 - 01-12-2021
Invesitgating the role of omega-3 derived resolvins in inflammatory arthritisLucy Norling
£334,897 AR-UK Versus Arthritis
01-05-2012 - 30-11-2018