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Prof Fran Balkwill

Fran Balkwill

Centre Lead, Cancer and Inflammation

Barts Cancer Institute
School of Medicine & Dentistry, Queen Mary University of London

www.youtube.com/watch?v=v61ed9ojd48

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Mulvey KL, McGuire L, Hoffman AJ, Hartstone-Rose A, Winterbottom M, Balkwill F, Fields GE, Burns K, Drews M, Chatton M, Eaves N, Law F, Joy A and Rutland A (2020). Learning hand in hand: Engaging in research-practice partnerships to advance developmental science. New Dir Child Adolesc Dev  vol. 2020, (172) 125-134. 10.1002/cad.20364
Whitehouse AL, Mushtaq N, Miyashita L, Barratt B, Khan A, Kalsi H, Koh L, Padovan MG, Brugha R, Balkwill FR, Stagg AJ and Grigg J (2020). Airway dendritic cell maturation in children exposed to air pollution. Public Library of Science (Plos)  Plos One  vol. 15, (5) e0232040-e0232040. 10.1371/journal.pone.0232040
Montfort A, Owen S, Piskorz AM, Supernat A, Moore L, Al-Khalidi S, Böhm S, Pharoah P, McDermott J, Balkwill FR and Brenton JD (2020). Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma. Springer Nature [Academic Journals On Nature.Com]  British Journal of Cancer  10.1038/s41416-020-0822-x
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker A-M, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Balkwill FR, Sosabowski J, Cutillas PR, Frezza C, Sancho P and Hodivala-Dilke K (2020). Cancer associated fibroblast FAK regulates malignant cell metabolism. Nature Research (Part of Springer Nature)  Nature Communications  vol. 11, (1) 1290-1290. 10.1038/s41467-020-15104-3
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joyce JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill F (2020). Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Elsevier Bv  Ssrn Electronic Journal  10.2139/ssrn.3411253

2019

Marques P, Barry S, Carlsen E, Collier D, Ronaldson A, Awad S, Dorward N, Grieve J, Mendoza N, Muquit S, Grossman AB, Balkwill F and Korbonits M (2019). Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours. Acta Neuropathologica Communications  vol. 7, (1) 10.1186/s40478-019-0830-3
Bast RC, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z and Mills GB (2019). Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer  vol. 125, (12) 1963-1972. 10.1002/cncr.32004
Spear S, Candido JB, McDermott JR, Ghirelli C, Maniati E, Beers SA, Balkwill FR, Kocher HM and Capasso M (2019). Discrepancies in the tumor microenvironment of spontaneous and orthotopic murine models of pancreatic cancer uncover a new immunostimulatory phenotype for B cells. Frontiers Media  Frontiers in Immunology  vol. 10, (MAR) 10.3389/fimmu.2019.00542
Marques P, Barry S, Carlsen E, Collier D, Ronaldson A, Awad S, Dorward N, Grieve J, Mendoza N, Muquit S, Grossman AB, Balkwill F and Korbonits M (2019). Pituitary tumour fibroblast-derived cytokines influence tumour aggressiveness. Endocrine-Related Cancer  vol. 26, (12) 853-865. 10.1530/ERC-19-0327

2018

Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR and Hynes RO (2018). Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. Journal of Proteome Research  vol. 16, (8) 3083-3091. 10.1021/acs.jproteome.7b00191
Sanz-Moreno V and Balkwill FR (2018). Mets and NETs: The Awakening Force. Immunity  vol. 49, (5) 798-800. 10.1016/j.immuni.2018.11.009
Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A, Clark W, McGhee EJ, Wang J, Escorcio-Correia M, Zollinger R, Roshani R, Drew L, Rishi L, Arkell R, Evans TRJ, Nixon C, Jodrell DI, Wilkinson RW, Biankin AV, Barry ST, Balkwill FR and Sansom OJ (2018). CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype. Cell Reports  vol. 23, (5) 1448-1460. 10.1016/j.celrep.2018.03.131
Malik STA and Balkwill FR (2018). Cytokines. The Nude Mouse in Oncology Research  10.1201/9781351077217

2017

Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov  10.1158/2159-8290.CD-17-0284
(2017). A guiding map for inflammation. Nat Immunol  vol. 18, (8) 826-831. 10.1038/ni.3790
BALKWILL F, Berlato C, Khan MN, Schioppa T, Thompson R, Maniati E, Montfort A, Jangani M, Canosa M, Kulbe H, Hagemann U, Duncan A, Fletcher L, Wilkinson RW, Powles T and Quezada S (2017). A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer. American Society For Clinical Investigation  Journal of Clinical Investigation  10.1172/JCI82976

2016

Delaine-Smith RM, Burney S, Balkwill FR and Knight MM (2016). Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics. Elsevier  Journal of The Mechanical Behavior of Biomedical Materials  vol. 60, 401-415. 10.1016/j.jmbbm.2016.02.019
Steele CW, Karim SA, Leach JDG, Bailey P, Upstill-Goddard R, Rishi L, Foth M, Bryson S, McDaid K, Wilson Z, Eberlein C, Candido JB, Clarke M, Nixon C, Connelly J, Jamieson N, Carter CR, Balkwill F, Chang DK, Evans TRJ, Strathdee D, Biankin AV, Nibbs RJB, Barry ST, Sansom OJ and Morton JP (2016). CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma. Elsevier (Cell Press)  Cancer Cell  vol. 29, (6) 832-845. 10.1016/j.ccell.2016.04.014
GROSE RP, Dawkins JBN, Wang J, maniati , heward , koniali , kocher , martin , chelala , balkwill and fitzgibbon (2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. American Association For Cancer Research  Cancer Research  10.1158/0008-5472.CAN-16-0481
BALKWILL F, Anne Montfort and Oliver Pearce (2016). Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma. American Association For Cancer Research  Clinical Cancer Research  10.1158/1078-0432.CCR-15-2657
Kulbe H, Iorio F, Chakravarty P, Milagre CS, Moore R, Thompson RG, Everitt G, Canosa M, Montoya A, Drygin D, Braicu I, Sehouli J, Saez-Rodriguez J, Cutillas PR and Balkwill FR (2016). Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells. Oncotarget  vol. 7, (13) 15648-15661. 10.18632/oncotarget.7255
Walton J, Dowson S, Ennis D, Leung E, Farquharson M, Stevenson D, Blyth K, Strathdee D, Balkwill FR, Lockley M and McNeish IA (2016). Abstract B53: CRISPR/Cas9 mediated p53 and BRCA2 knockout to generate improved murine models of high grade serous ovarian cancer. 10.1158/1557-3265.ovca15-b53

2015

Crusz SM and Balkwill FR (2015). Inflammation and cancer: Advances and new agents. Nature Reviews Clinical Oncology  vol. 12, (10) 584-596. 10.1038/nrclinonc.2015.105
Balkwill F and Chambers K (2015). Centre of the Cell: Science Comes to Life. Plos Biology  vol. 13, (9) 10.1371/journal.pbio.1002240
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Interleukin-6 stimulates defective angiogenesis. Cancer Research  vol. 75, (15) 3098-3107. 10.1158/0008-5472.CAN-15-1227
Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Abstract 4162: Interleukin–6 stimulates defective angiogenesis. 10.1158/1538-7445.am2015-4162
Milagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R, Bowtell DDL, Hochhauser D and Balkwill FR (2015). Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL6 antibodies, with implications for combined therapy in ovarian cancer. Cancer Research  vol. 75, (7) 1255-1264. 10.1158/0008-5472.CAN-14-1801
Balkwill F (2015). Targeting inflammatory cytokines in cancer. Clinical & Experimental Metastasis  vol. 32, (3) 183-183.
Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, Edmondson R, Fotopoulou C, Gabra H, Galon J, Gourley C, Heong V, Huntsman DG, Iwanicki M, Karlan BY, Kaye A, Lengyel E, Levine DA, Lu KH, McNeish IA and Menon U (2015). Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer. Nature Reviews Cancer  vol. 15, (11) 668-679. 10.1038/nrc4019

2014

Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ and Silva-Santos B (2014). Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A  vol. 111, (34) E3562-E3570. 10.1073/pnas.1403424111
Balkwill F (2014). 33: Targeting cancer-related inflammation. European Journal of Cancer  vol. 50, 10.1016/s0959-8049(14)50033-0
Karin M, Jobin C and Balkwill F (2014). Chemotherapy, immunity and microbiota--a new triumvirate? Nat Med  vol. 20, (2) 126-127. 10.1038/nm.3473
Lau T-S, Chung TK-H, Cheung T-H, Chan LK-Y, Cheung LW-H, Yim S-F, Siu NS-S, Lo K-W, Yu MM-Y, Kulbe H, Balkwill FR and Kwong J (2014). Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts. J Pathol  vol. 232, (1) 43-56. 10.1002/path.4258

2013

Whilding LM, Archibald KM, Kulbe H, Balkwill FR, Öberg D and McNeish IA (2013). Vaccinia virus induces programmed necrosis in ovarian cancer cells. Mol Ther  vol. 21, (11) 2074-2086. 10.1038/mt.2013.195
Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T, Imhof BA, Balkwill FR and Nourshargh S (2013). Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. Faseb J  vol. 27, (10) 4244-4253. 10.1096/fj.13-230441
Balkwill F, Montfort A and Capasso M (2013). B regulatory cells in cancer. Trends Immunol  vol. 34, (4) 169-173. 10.1016/j.it.2012.10.007
Sandhu SK, Papadopoulos K, Fong PC, Patnaik A, Messiou C, Olmos D, Wang G, Tromp BJ, Puchalski TA, Balkwill F, Berns B, Seetharam S, de Bono JS and Tolcher AW (2013). A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors. Cancer Chemother Pharmacol  vol. 71, (4) 1041-1050. 10.1007/s00280-013-2099-8

2012

Balkwill FR, Capasso M and Hagemann T (2012). The tumor microenvironment at a glance. J Cell Sci  vol. 125, (Pt 23) 5591-5596. 10.1242/jcs.116392
Archibald KM, Kulbe H, Kwong J, Chakravarty P, Temple J, Chaplin T, Flak MB, McNeish IA, Deen S, Brenton JD, Young BD and Balkwill F (2012). Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium. Oncogene  vol. 31, (48) 4987-4995. 10.1038/onc.2011.653
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and Balkwill FR (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol  vol. 227, (2) 136-145. 10.1002/path.4002
Kulbe H, Chakravarty P, Moore R, Iorio F, Montoya A, Saez-Rodriguez J, Cutillas P and Balkwill F (2012). Abstract 49: Targeting the TNF network in human ovarian cancer - A systems biology approach. 10.1158/1538-7445.am2012-49
Affara NI, Ruffell B, Johansson M, Fujikawa K, Bergsland E, DeNardo DG, Chen HI, Wadhwani N, Steinhoff M, Truitt M, Olson P, Hanahan D, Li Y, Gong Q, Ma Y, Wiesen JF, Kim G, Tempero M, Balkwill F, Irving B and Coussens LM (2012). Abstract 4391: CD20 as a target for therapy in solid tumors. 10.1158/1538-7445.am2012-4391
Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupairmoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Hu W, Gershenson H, Matsuo K, Shahzad MMK, King ER, Tekedereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Lamkin D, Collins K, DeGeest K and Lutgendorf SK (2012). Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med  vol. 366, (7) 610-618. 10.1056/NEJMoa1110352
Balkwill FR and Mantovani A (2012). Cancer-related inflammation: common themes and therapeutic opportunities. Semin Cancer Biol  vol. 22, (1) 33-40. 10.1016/j.semcancer.2011.12.005
Balkwill FR (2012). The chemokine system and cancer. J Pathol  vol. 226, (2) 148-157. 10.1002/path.3029
Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Australian Ovarian Cancer Study Group , Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD and Balkwill FR (2012). A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res  vol. 72, (1) 66-75. 10.1158/0008-5472.CAN-11-2178

2011

Balkwill FR, Coward J, Kulbe H, Milagre C, Gopinathan G and McNeish IA (2011). IL-6 and ovarian cancer--response. Clin Cancer Res  vol. 17, (24) 10.1158/1078-0432.CCR-11-2680
Maniati E, Bossard M, Cook N, Candido JB, Emami-Shahri N, Nedospasov SA, Balkwill FR, Tuveson DA and Hagemann T (2011). Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J Clin Invest  vol. 121, (12) 4685-4699. 10.1172/JCI45797
Balkwill F (2011). The inflammatory tissue microenvironment and the early stages of malignancy. Pre-Invasive Disease: Pathogenesis and Clinical Management  10.1007/978-1-4419-6694-0_2
Coward J and Balkwill F (2011). Targeting inflammatory pathways in epithelial ovarian cancer. Emerging Therapeutic Targets in Ovarian Cancer  10.1007/978-1-4419-7216-3_7
Vaughan S, Coward JI, Bast RC, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, Friedlander M, Gabra H, Kaye SB, Lord CJ, Lengyel E, Levine DA, McNeish IA, Menon U, Mills GB, Nephew KP, Oza AM, Sood AK, Stronach EA, Walczak H, Bowtell DD and Balkwill FR (2011). Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer  vol. 11, (10) 719-725. 10.1038/nrc3144
Coward J, Kulbe H, Chakravarty P, Leader D, Vassileva V, Leinster DA, Thompson R, Schioppa T, Nemeth J, Vermeulen J, Singh N, Avril N, Cummings J, Rexhepaj E, Jirström K, Gallagher WM, Brennan DJ, McNeish IA and Balkwill FR (2011). Interleukin-6 as a therapeutic target in human ovarian cancer. Clin Cancer Res  vol. 17, (18) 6083-6096. 10.1158/1078-0432.CCR-11-0945
Balkwill F, Whitehead S, Willis P, Gaymond N, Kent A, Page C, Lovell-Badge R, Morris R, Lemon R and Banks D (2011). Safety of medicines and the use of animals in research. Lancet  vol. 378, (9786) 127-128. 10.1016/S0140-6736(11)60984-7
Schioppa T, Moore R, Thompson RG, Rosser EC, Kulbe H, Nedospasov S, Mauri C, Coussens LM and Balkwill FR (2011). B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis. Proc Natl Acad Sci U S A  vol. 108, (26) 10662-10667. 10.1073/pnas.1100994108
Allan S and Balkwill F (2011). Translating science in more ways than one: an interview with Frances Balkwill. Dis Model Mech  vol. 4, (3) 286-288. 10.1242/dmm.007898
Anglesio MS, George J, Kulbe H, Friedlander M, Rischin D, Lemech C, Power J, Coward J, Cowin PA, House CM, Chakravarty P, Gorringe KL, Campbell IG, Australian Ovarian Cancer Study Group , Okamoto A, Birrer MJ, Huntsman DG, de Fazio A, Kalloger SE, Balkwill F, Gilks CB and Bowtell DD (2011). IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Clin Cancer Res  vol. 17, (8) 2538-2548. 10.1158/1078-0432.CCR-10-3314
Salako MA, Kulbe H, Ingemarsdotter CK, Pirlo KJ, Williams SL, Lockley M, Balkwill FR and McNeish IA (2011). Inhibition of the inflammatory cytokine TNF-α increases adenovirus activity in ovarian cancer via modulation of cIAP1/2 expression. Mol Ther  vol. 19, (3) 490-499. 10.1038/mt.2010.247

2010

Balkwill F and Joffroy C (2010). TNF: a tumor-suppressing factor or a tumor-promoting factor? Future Oncol  vol. 6, (12) 1833-1836. 10.2217/fon.10.155
Flak MB, Connell CM, Chelala C, Archibald K, Salako MA, Pirlo KJ, Lockley M, Wheatley SP, Balkwill FR and McNeish IA (2010). p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker. Mol Cancer  vol. 9, 10.1186/1476-4598-9-175
Toulza F, Nosaka K, Tanaka Y, Schioppa T, Balkwill F, Taylor GP and Bangham CRM (2010). Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells. J Immunol  vol. 185, (1) 183-189. 10.4049/jimmunol.0903846
Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DAH, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA and Committee of the National Cancer Research Institute (2010). Guidelines for the welfare and use of animals in cancer research. Br J Cancer  vol. 102, (11) 1555-1577. 10.1038/sj.bjc.6605642
Balkwill F and Mantovani A (2010). Cancer and inflammation: implications for pharmacology and therapeutics. Clin Pharmacol Ther  vol. 87, (4) 401-406. 10.1038/clpt.2009.312
(2010). Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers. Proc Natl Acad Sci U S A  vol. 107, (5) 2177-2182. 10.1073/pnas.0909797107
Balkwill F and Mantovani A (2010). Foreword. Cytokine Growth Factor Rev  vol. 21, (1) 10.1016/j.cytogfr.2009.11.004

2009

Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A, Chakravarty P, Thompson RG, Kollias G, Smyth JF, Balkwill FR and Hagemann T (2009). The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J Clin Invest  vol. 119, (10) 3011-3023. 10.1172/JCI39065
Kwong J, Kulbe H, Wong D, Chakravarty P and Balkwill F (2009). An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther  vol. 8, (7) 1893-1905. 10.1158/1535-7163.MCT-08-0966
Kwong J, Chan FL, Wong K-K, Birrer MJ, Archibald KM, Balkwill FR, Berkowitz RS and Mok SC (2009). Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells. Neoplasia  vol. 11, (6) 529-541. 10.1593/neo.09112
Archibald K, Kwong J, Kulbe H, Young B and Balkwill F (2009). Spontaneously transformed hTERT immortalized human ovarian surface epithelial cells have a functional amplification of the CXCR4 gene locus. Cancer Research  vol. 69,
Coward J, Quigley M, Leader D, Berns B, Balkwill F and McNeish I (2009). A Phase II study of intravenous CNT0328 in patients with recurrent epithelial ovarian cancer. Cancer Research  vol. 69,
Schioppa T, Moore R, Thompson R, de Visser K, Coussens L and Balkwill F (2009). Role of B cell in two-stage skin carcinogenesis. Cancer Research  vol. 69,
Balkwill F (2009). Tumour necrosis factor and cancer. Nat Rev Cancer  vol. 9, (5) 361-371. 10.1038/nrc2628
Li NF, Kocher HM, Salako MA, Obermueller E, Sandle J and Balkwill F (2009). A novel function of colony-stimulating factor 1 receptor in hTERT immortalization of human epithelial cells. Oncogene  vol. 28, (5) 773-780. 10.1038/onc.2008.412

2008

Mantovani A, Allavena P, Sica A and Balkwill F (2008). Cancer-related inflammation. Nature  vol. 454, (7203) 436-444. 10.1038/nature07205
Brown ER, Charles KA, Hoare SA, Rye RL, Jodrell DI, Aird RE, Vora R, Prabhakar U, Nakada M, Corringham RE, DeWitte M, Sturgeon C, Propper D, Balkwill FR and Smyth JF (2008). A clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancer. Ann Oncol  vol. 19, (7) 1340-1346. 10.1093/annonc/mdn054
Hagemann T, Lawrence T, McNeish I, Charles KA, Kulbe H, Thompson RG, Robinson SC and Balkwill FR (2008). Re-educating tumor-associated macrophages by targeting NF-kappaB. J Exp Med  vol. 205, (6) 1261-1268. 10.1084/jem.20080108
Ashworth A, Balkwill F, Bast RC, Berek JS, Kaye A, Boyd JA, Mills G, Weinstein JN, Woolley K and Workman P (2008). Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007. Gynecol Oncol  vol. 108, (3) 652-657. 10.1016/j.ygyno.2007.11.014
Karagiannis SN, Bracher MG, Beavil RL, Beavil AJ, Hunt J, McCloskey N, Thompson RG, East N, Burke F, Sutton BJ, Dombrowicz D, Balkwill FR and Gould HJ (2008). Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells. Cancer Immunol Immun  vol. 57, (2) 247-263. 10.1007/s00262-007-0371-7

2007

Li NF, Broad S, Lu YJ, Yang JS, Watson R, Hagemann T, Wilbanks G, Jacobs I, Balkwill F, Dafou D and Gayther SA (2007). Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression. Cell Prolif  vol. 40, (5) 780-794. 10.1111/j.1365-2184.2007.00462.x
Hagemann T, Balkwill F and Lawrence T (2007). Inflammation and cancer: A double-edged sword. Cancer Cell  vol. 12, (4) 300-301. 10.1016/j.ccr.2007.10.005
Karagiannis SN, Bracher MG, Hunt J, McCloskey N, Beavil RL, Beavil AJ, Fear DJ, Thompson RG, East N, Burke F, Moore RJ, Dombrowicz DD, Balkwill FR and Gould HJ (2007). IgE-antibody-dependent immunotherapy of solid tumors: Cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells. J Immunol  vol. 179, (5) 2832-2843. 10.4049/jimmunol.179.5.2832
Lawrence T, Hageman T and Balkwill F (2007). Cancer. Sex, cytokines, and cancer. Science  vol. 317, (5834) 51-52. 10.1126/science.1146052
Szlosarek PW, Grimshaw MJ, Wilbanks GD, Hagemann T, Wilson JL, Burke F, Stamp G and Balkwill FR (2007). Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer. Int J Cancer  vol. 121, (1) 6-11. 10.1002/ijc.22666
Hagemann T, Robinson SC, Thompson RG, Charles K, Kulbe H and Balkwill FR (2007). Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis. Mol Cancer Ther  vol. 6, (7) 1993-2002. 10.1158/1535-7163.MCT-07-0118
Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, Gould D, Ayhan A and Balkwill F (2007). The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res  vol. 67, (2) 585-592. 10.1158/0008-5472.CAN-06-2941

2006

Szlosarek PW, Klabatsa A, Pallaska A, Sheaff M, Smith P, Crook T, Grimshaw MJ, Steele JP, Rudd RM, Balkwill FR and Fennell DA (2006). In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion. Clin Cancer Res  vol. 12, (23) 7126-7131. 10.1158/1078-0432.CCR-06-1101
Mantovani A and Balkwill F (2006). RaIB signaling: A bridge between inflammation and cancer. Cell  vol. 127, (1) 42-44. 10.1016/j.cell.2006.09.019
Balkwill F (2006). TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev  vol. 25, (3) 409-416. 10.1007/s10555-006-9005-3
Strauss SJ, Maharaj L, Hoare S, Johnson PW, Radford JA, Vinnecombe S, Millard L, Rohatiner A, Boral A, Trehu E, Schenkein D, Balkwill F, Joel SP and Lister TA (2006). Bortezomib therapy in patients with relapsed or refractory lymphoma: potential correlation of in vitro sensitivity and tumor necrosis factor alpha response with clinical activity. J Clin Oncol  vol. 24, (13) 2105-2112. 10.1200/JCO.2005.04.6789
Hagemann T, Wilson J, Burke F, Kulbe H, Li NF, Pluddemann A, Charles K, Gordon S and Balkwill FR (2006). Ovarian cancer cells polarize macrophages towards a tumor-associated phenotype. Med Klin  vol. 101, (4) A44-A44.
Hagemann T, Wilson J, Burke F, Kulbe H, Li NF, Plüddemann A, Charles K, Gordon S and Balkwill FR (2006). Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol  vol. 176, (8) 5023-5032. 10.4049/jimmunol.176.8.5023
Balkwill F (2006). Cancer and inflammation. Eur J Cancer  vol. 42, (6) 689-690. 10.1016/j.ejca.2006.03.002
Szlosarek P, Charles KA and Balkwill FR (2006). Tumour necrosis factor-alpha as a tumour promoter. Eur J Cancer  vol. 42, (6) 745-750. 10.1016/j.ejca.2006.01.012
Balkwill FR, Ashworth A, Bast RC, Berek JS, Boyd J, Disis ML, Gabra H, Gore ME, Hamilton TC, Jacobs IJ, Kaye SB, Kohn EC, Mills GB and Urban ND (2006). 10th Biennial Helene Harris Memorial Trust meeting. Cancer Res  vol. 66, (6) 2904-2906. 10.1158/0008-5472.CAN-05-2093
Balkwill F (2006). Inflammation: a double-edged sword. Eur J Cancer  vol. 42, (5) 571-571.
Szlosarek PW, Grimshaw MJ, Kulbe H, Wilson JL, Wilbanks GD, Burke F and Balkwill FR (2006). Expression and regulation of tumor necrosis factor alpha in normal and malignant ovarian epithelium. Mol Cancer Ther  vol. 5, (2) 382-390. 10.1158/1535-7163.MCT-05-0303

2005

Kulbe H, Hagemann T, Szlosarek PW, Balkwill FR and Wilson JL (2005). The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells. Cancer Res  vol. 65, (22) 10355-10362. 10.1158/0008-5472.CAN-05-0957
Hagemann T and Balkwill F (2005). MIFed about cancer? Gastroenterology  vol. 129, (5) 1785-1787. 10.1053/j.gastro.2005.09.039
Madhusudan S, Muthuramalingam SR, Braybrooke JP, Wilner S, Kaur K, Han C, Hoare S, Balkwill F and Ganesan TS (2005). Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer. J Clin Oncol  vol. 23, (25) 5950-5959. 10.1200/JCO.2005.04.127
Hagemann T, Wilson J, Kulbe H, Li NF, Leinster DA, Charles K, Klemm F, Pukrop T, Binder C and Balkwill FR (2005). Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J Immunol  vol. 175, (2) 1197-1205. 10.4049/jimmunol.175.2.1197
Barton C, Davies D, Balkwill F and Burke F (2005). Involvement of both intrinsic and extrinsic pathways in IFN-gamma-induced apoptosis that are enhanced with cisplatin. Eur J Cancer  vol. 41, (10) 1474-1486. 10.1016/j.ejca.2005.03.022
Balkwill F (2005). The language of life: How cells communicate in health and disease. Nature  vol. 435, (7046) 1162-1162. 10.1038/4351162a
Balkwill F (2005). Immunology for the next generation. Nat Rev Immunol  vol. 5, (6) 509-512. 10.1038/nri1628
Balkwill F and Watt F (2005). Fran Balkwill. J Cell Sci  vol. 118, (Pt 7) 1339-1340. 10.1242/jcs.01688
Balkwill F, Charles KA and Mantovani A (2005). Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell  vol. 7, (3) 211-217. 10.1016/j.ccr.2005.02.013

2004

Madhusudan S, Foster M, Muthuramalingam SR, Braybrooke JP, Wilner S, Kaur K, Han C, Hoare S, Balkwill F, Talbot DC, Ganesan TS and Harris AL (2004). A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer. Clin Cancer Res  vol. 10, (19) 6528-6534. 10.1158/1078-0432.CCR-04-0730
Balkwill F and Coussens LM (2004). Cancer - An inflammatory link. Nature  vol. 431, (7007) 405-406. 10.1038/431405a
Scott KA, Arnott CH, Robinson SC, Moore RJ, Thompson RG, Marshall JF and Balkwill FR (2004). TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration? Oncogene  vol. 23, (41) 6954-6966. 10.1038/sj.onc.1207915
Hagemann T, Robinson SC, Schulz M, Trümper L, Balkwill FR and Binder C (2004). Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis  vol. 25, (8) 1543-1549. 10.1093/carcin/bgh146
Jones PH, Christodoulos K, Dobbs N, Thavasu P, Balkwill F, Blann AD, Caine GJ, Kumar S, Kakkar AJ, Gompertz N, Talbot DC, Ganesan TS and Harris AL (2004). Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer. Br J Cancer  vol. 91, (1) 30-36. 10.1038/sj.bjc.6601897
Balkwill F (2004). Cancer and the chemokine network. Nat Rev Cancer  vol. 4, (7) 540-550. 10.1038/nrc1388
Li NF, Wilbanks G, Balkwill F, Jacobs IJ, Dafou D and Gayther SA (2004). A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro. Lab Invest  vol. 84, (7) 923-931. 10.1038/labinvest.3700093
Balkwill F (2004). The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol  vol. 14, (3) 171-179. 10.1016/j.semcancer.2003.10.003
Grimshaw MJ, Hagemann T, Ayhan A, Gillett CE, Binder C and Balkwill FR (2004). A role for endothelin-2 and its receptors in breast tumor cell invasion. Cancer Res  vol. 64, (7) 2461-2468. 10.1158/0008-5472.can-03-1069
Arnott CH, Scott KA, Moore RJ, Robinson SC, Thompson RG and Balkwill FR (2004). Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. Oncogene  vol. 23, (10) 1902-1910. 10.1038/sj.onc.1207317
Balkwill F, Bast RC, Berek J, Chenevix-Trench G, Gore M, Hamilton T, Jacobs I, Mills G, Souhami R, Urban N, Orsulic S and Smyth J (2004). Current research and treatment for epithelial ovarian cancer. A position paper from the Helene Harris Memorial Trust (vol 39, pg 1818, 2003). Eur J Cancer  vol. 40, (4) 628-628. 10.1016/j.ejca.2003.11.005
Kulbe H, Levinson NR, Balkwill F and Wilson JL (2004). The chemokine network in cancer - much more than directing cell movement. Int J Dev Biol  vol. 48, (5-6) 489-496. 10.1387/ijdb.041814hk
Szlosarek P and Balkwill F (2004). The inflammatory cytokine network of epithelial cancer: therapeutic implications. Novartis Found Symp  vol. 256, 227-237. 10.1002/0470856734.ch17

2003

Robinson SC, Scott KA, Wilson JL, Thompson RG, Proudfoot AEI and Balkwill FR (2003). A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res  vol. 63, (23) 8360-8365.
Madhusudan S, Protheroe A, Propper D, Han C, Corrie P, Earl H, Hancock B, Vasey P, Turner A, Balkwill F, Hoare S and Harris AL (2003). A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer. Brit J Cancer  vol. 89, (8) 1418-1422. 10.1038/sj.bjc.6601321
Szlosarek PW and Balkwill FR (2003). Tumour necrosis factor alpha: a potential target for the therapy of solid tumours. Lancet Oncol  vol. 4, (9) 565-573. 10.1016/s1470-2045(03)01196-3
Balkwill F, Bast RC, Berek J, Chenevix-Trench G, Gore M, Hamilton T, Jacobs I, Mills G, Souhami R, Urban N, Orsulic S and Smyth J (2003). Current research and treatment for epithelial ovarian cancer. A Position Paper from the Helene Harris Memorial Trust. Eur J Cancer  vol. 39, (13) 1818-1827. 10.1016/s0959-8049(03)00511-2
Wall L, Burke F, Barton C, Smyth J and Balkwill F (2003). IFN-gamma induces apoptosis in ovarian cancer cells in vivo and in vitro. Clin Cancer Res  vol. 9, (7) 2487-2496.
Wall L, Burke F, Barton C, Smyth J and Balkwill F (2003). IFN-γ induces apoptosis in ovarian cancer cells in vivo and in vitro. Clinical Cancer Research  vol. 9, (7) 2487-2496.
Scott KA, Moore RJ, Arnott CH, East N, Thompson RG, Scallon BJ, Shealy DJ and Balkwill FR (2003). An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors. Mol Cancer Ther  vol. 2, (5) 445-451.
Karagiannis SN, Wang Q, East N, Burke F, Riffard S, Bracher MG, Thompson RG, Durham SR, Schwartz LB, Balkwill FR and Gould HJ (2003). Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol  vol. 33, (4) 1030-1040. 10.1002/eji.200323185
Balkwill F (2003). Chemokine biology in cancer. Semin Immunol  vol. 15, (1) 49-55. 10.1016/s1044-5323(02)00127-6
Wall L, Burke F, Smyth JF and Balkwill F (2003). The anti-proliferative activity of interferon-gamma on ovarian cancer: in vitro and in vivo. Gynecologic Oncology  vol. 88, (1 Pt 2) 10.1006/gyno.2002.6707
Propper DJ, Chao D, Braybrooke JP, Bahl P, Thavasu P, Balkwill F, Turley H, Dobbs N, Gatter K, Talbot DC, Harris AL and Ganesan TS (2003). Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma. Clin Cancer Res  vol. 9, (1) 84-92.

2002

Grimshaw MJ, Naylor S and Balkwill FR (2002). Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells. Mol Cancer Ther  vol. 1, (14) 1273-1281.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G and Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res  vol. 62, (20) 5930-5938.
Grimshaw MJ, Wilson JL and Balkwill FR (2002). Endothelin-2 is a macrophage chemoattractant: Implications for macrophage distribution in tumors. European Journal of Immunology  vol. 32, (9) 2393-2400. 10.1002/1521-4141(200209)32:9<2393::AID-IMMU2393>3.0.CO;2-4
Grimshaw MJ, Wilson JL and Balkwill FR (2002). Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol  vol. 32, (9) 2393-2400. 10.1002/1521-4141(200209)32:9<2393::AID-IMMU2393>3.0.CO;2-4
Arnott CH, Scott KA, Moore RJ, Hewer A, Phillips DH, Parker P, Balkwill FR and Owens DM (2002). Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway. Oncogene  vol. 21, (31) 4728-4738. 10.1038/sj.onc.1205588
Forster MD, Braybrooke J, Madhusudan S, Kaur K, Hoare S, Balkwill F, Ganesan TS, Talbot D and Harris AL (2002). A phase II trial using etanercept, a recombinant tumour necrosis factor antagonist, in metastatic breast cancer. Brit J Cancer  vol. 86, S38-S38.
Wall L, Burke F, Smyth J and Balkwill F (2002). Characterisation of the cell content of malignant ascites in advanced epithelial ovarian cancer and clinico-pathological correlations. Brit J Cancer  vol. 86, S45-S46.
Milliken D, Scotton C, Raju S, Balkwill F and Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res  vol. 8, (4) 1108-1114.
Balkwill F (2002). Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev  vol. 13, (2) 135-141. 10.1016/s1359-6101(01)00020-x
Wilson J and Balkwill F (2002). The role of cytokines in the epithelial cancer microenvironment. Semin Cancer Biol  vol. 12, (2) 113-120. 10.1006/scbi.2001.0419
Robinson SC, Scott KA and Balkwill FR (2002). Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-α. European Journal of Immunology  vol. 32, (2) 404-412. 10.1002/1521-4141(200202)32:2<404::AID-IMMU404>3.0.CO;2-X
Robinson SC, Scott KA and Balkwill FR (2002). Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-alpha. Eur J Immunol  vol. 32, (2) 404-412. 10.1002/1521-4141(200202)32:2<404::AID-IMMU404>3.0.CO;2-X

2001

Balkwill F (2001). The science book. Nature  vol. 414, (6866) 849-850. 10.1038/414849a
Scotton C, Milliken D, Wilson J, Raju S and Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer  vol. 85, (6) 891-897. 10.1054/bjoc.2001.2020
Scotton CJ, Wilson JL, Milliken D, Stamp G and Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors? Cancer Res  vol. 61, (13) 4961-4965.
Grimsha MJ and Balkwill FR (2001). Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - A potential mechanism. Brit J Cancer  vol. 85, 19-19.
Grimshaw MJ and Balkwill FR (2001). Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - A potential mechanism. European Journal of Immunology  vol. 31, (2) 480-489. 10.1002/1521-4141(200102)31:2<480::AID-IMMU480>3.0.CO;2-L
Propper DJ, McDonald AC, Man A, Thavasu P, Balkwill F, Braybrooke JP, Caponigro F, Graf P, Dutreix C, Blackie R, Kaye SB, Ganesan TS, Talbot DC, Harris AL and Twelves C (2001). Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol  vol. 19, (5) 1485-1492. 10.1200/JCO.2001.19.5.1485
Balkwill F and Mantovani A (2001). Inflammation and cancer: back to Virchow? Lancet  vol. 357, (9255) 539-545. 10.1016/S0140-6736(00)04046-0
Grimshaw MJ and Balkwill FR (2001). Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - a potential mechanism. Eur J Immunol  vol. 31, (2) 480-489. 10.1002/1521-4141(200102)31:2<480::aid-immu480>3.0.co;2-l

2000

Jankowski JA, Harrison RF, Perry I, Balkwill F and Tselepis C (2000). Barrett's metaplasia. Lancet  vol. 356, (9247) 2079-2085. 10.1016/S0140-6736(00)03411-5
Balkwill FR (2000). Re: Possible role of ovarian epithelial inflammation in ovarian cancer. J Natl Cancer Inst  vol. 92, (2) 162-163. 10.1093/jnci/92.2.162a
Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F and Mantovani A (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. Journal of Immunology  vol. 164, (2) 733-738. 10.4049/jimmunol.164.2.733
Scott KA, Holdsworth H, Balkwill FR and Dias S (2000). Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model. British Journal of Cancer  vol. 83, (11) 1538-1543. 10.1054/bjoc.2000.1487

1999

Thavasu P, Propper D, McDonald A, Dobbs N, Ganesan T, Talbot D, Braybrook J, Caponigro F, Hutchison C, Twelves C, Man A, Fabbro D, Harris A and Balkwill F (1999). The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients. Cancer Research  vol. 59, (16) 3980-3984.
Turner L, Scotton C, Negus R and Balkwill F (1999). Hypoxia inhibits macrophage migration. European Journal of Immunology  vol. 29, (7) 2280-2287. 10.1002/(SICI)1521-4141(199907)29:07<2280::AID-IMMU2280>3.0.CO;2-C
Turner L, Scotton C, Negus R and Balkwill F (1999). Hypoxia inhibits macrophage migration. Eur J Immunol  vol. 29, (7) 2280-2287. 10.1002/(SICI)1521-4141(199907)29:07<2280::AID-IMMU2280>3.0.CO;2-C
Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N, Holdsworth H, Turner L, Rollins B, Pasparakis M, Kollias G and Balkwill F (1999). Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis. Nature Medicine  vol. 5, (7) 828-831. 10.1038/10552
Burke F, Smith PD, Crompton MR, Upton C and Balkwill FR (1999). Cytotoxic response of ovarian cancer cell lines to IFN-γ is associated with sustained induction of IRF-1 and p21 mRNA. British Journal of Cancer  vol. 80, (8) 1236-1244. 10.1038/sj.bjc.6690491
Boyd RS and Balkwill FR (1999). MMP-2 release and activation in ovarian carcinoma: The role of fibroblasts. British Journal of Cancer  vol. 80, (3-4) 315-321. 10.1038/sj.bjc.6690357
Balkwill F (1999). TNF biosynthesis in gut associated immunopathologies. Gut  vol. 45, (4) 10.1136/gut.45.4.483
Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N, Holdsworth H, Turner L, Rollins B, Pasparakis M, Kollias G and Balkwill F (1999). Erratum: Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis (Nature Medicine (1999) 5 (828-831)). Nature Medicine  vol. 5, (9) 10.1038/12532

1998

Dias S, Boyd R and Balkwill F (1998). IL-12 regulates VEGF and MMPs in a murine breast cancer model. Int J Cancer  vol. 78, (3) 361-365. 10.1002/(SICI)1097-0215(19981029)78:3<361::AID-IJC17>3.0.CO;2-9
Dias S, Boyd R and Balkwill F (1998). IL-12 regulates VEGF and MMPs in a murine breast cancer model. International Journal of Cancer  vol. 78, (3) 361-365. 10.1002/(SICI)1097-0215(19981029)78:3<361::AID-IJC17>3.0.CO;2-9
Dias S, Thomas H and Balkwill F (1998). Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model. Int J Cancer  vol. 75, (1) 151-157. 10.1002/(sici)1097-0215(19980105)75:1<151::aid-ijc23>3.0.co;2-i
Dias S, Thomas H and Balkwill F (1998). Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model. International Journal of Cancer  vol. 75, (1) 151-157. 10.1002/(SICI)1097-0215(19980105)75:1<151::AID-IJC23>3.0.CO;2-I
Negus RPM, Turner L, Burke F and Balkwill FR (1998). Hypoxia down-regulates MCP-1 expression: Implications for macrophage distribution in tumors. Journal of Leukocyte Biology  vol. 63, (6) 758-765. 10.1002/jlb.63.6.758
Balkwill F (1998). The molecular and cellular biology of the chemokines. Journal of Viral Hepatitis  vol. 5, (1) 1-14. 10.1046/j.1365-2893.1998.00081.x
Leber TM and Balkwill FR (1998). Regulation of monocyte MMP-9 production by TNF-α and a tumour-derived soluble factor (MMPSF). British Journal of Cancer  vol. 78, (6) 724-732. 10.1038/bjc.1998.568
Workman P, Twentyman P, Balkwill F, Balmain A, Chaplin D, Double J, Embleton J, Newell D, Raymond R, Stables J, Stephens T, Wallace J and Navaratnam V (1998). United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). British Journal of Cancer  vol. 77, (1) 1-10. 10.1038/bjc.1998.1

1997

Leber TM and Balkwill FR (1997). Zymography: A single-step staining method for quantitation of proteolytic activity on substrate gels. Analytical Biochemistry  vol. 249, (1) 24-28. 10.1006/abio.1997.2170
Burke F, East N, Upton C, Patel K and Balkwill FR (1997). Interferon gamma induces cell cycle arrest and apoptosis in a model of ovarian cancer: Enhancement of effect by batimastat. European Journal of Cancer Part A  vol. 33, (7) 1114-1121. 10.1016/S0959-8049(97)88065-3
Balkwill F (1997). Cytokine amplification and inhibition of immune and inflammatory responses. Journal of Viral Hepatitis  vol. 4 Suppl 2, 6-15. 10.1111/j.1365-2893.1997.tb00175.x
Negus RPM, Stamp GWH, Hadley J and Balkwill FR (1997). Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. American Journal of Pathology  vol. 150, (5) 1723-1734.

1996

Zucker S and Balkwill FR (1996). Correspondence re: N-B. Liabakk et al., Matrix metalloprotease 2 (MMP- 2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res., 56: 190-196, 1996. Cancer Research  vol. 56, (15)
Burke F and Balkwill FR (1996). Cytokines in animal models of cancer. Biotherapy  vol. 8, (3-4) 229-241. 10.1007/BF01877209
Balkwill FR (1996). Cytokines in Hemopoiesis, Oncology, and Immunology III. British Journal of Cancer  vol. 73, (5) 711-711. 10.1038/bjc.1996.124
Burke F, Relf M, Negus R and Balkwill F (1996). A cytokine profile of normal and malignant ovary. Cytokine  vol. 8, (7) 578-585. 10.1006/cyto.1996.0077
Liabakk NB, Talbot I, Smith RA, Wilkinson K and Balkwill F (1996). Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Research  vol. 56, (1) 190-196.
Negus RPM and Balkwill FR (1996). Cytokines in tumour growth, migration and metastasis. World Journal of Urology  vol. 14, (3) 157-165. 10.1007/BF00186895
Thomas H, Hanby AM, Smith RA, Hagger P, Patel K, Raikundalia B, Camplejohn RS and Balkwill FR (1996). An inbred colony of oncogene transgenic mice: Diversity of tumours and potential as a therapeutic model. British Journal of Cancer  vol. 73, (1) 65-72. 10.1038/bjc.1996.12

1995

Balkwill F (1995). Making sense. Nature  vol. 378, (6554) 10.1038/378318b0
Thomas H and Balkwill F (1995). Assessing new anti-tumour agents and strategies in oncogene transgenic mice. Cancer and Metastasis Reviews  vol. 14, (2) 91-95. 10.1007/BF00665793
de Kossodo S, Moore R, Gschmeissner S, East N and Balkwill FR (1995). Changes in endogenous cytokines, adhesion molecules and platelets during cytokine-induced tumour necrosis. British Journal of Cancer  vol. 72, (5) 1165-1172. 10.1038/bjc.1995.481
Negus RPM, Stamp GWH, Relf MG, Burke F, Malik STA, Bernasconi S, Allavena P, Sozzani S, Mantovani A and Balkwill FR (1995). The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. Journal of Clinical Investigation  vol. 95, (5) 2391-2396. 10.1172/JCI117933
Thavasu PW, Ganjoo RK, Maidment SA, Love SB, Williams AH, Malplas JS and Balkwill FR (1995). Multiple myeloma: An immunoclinical study of disease and response to treatment. Hematological Oncology  vol. 13, (2) 69-82. 10.1002/hon.2900130204
Burke F, Knowles RG, East N and Balkwill FR (1995). THE role of indoleamine 2,3‐dioxygenase in the anti‐tumour activity of human interferon‐γ in vivo. International Journal of Cancer  vol. 60, (1) 115-122. 10.1002/ijc.2910600117
Balkwill F (1995). Tumour necrosis factor in ovarian cancer. Interferons and Cytokines  (26) 6-8.
Burger D, Dayer JM, Opdenakker G, Van Damme J, Mauviel A, Proost P, Gijbels K, Masure S, Carton H, Brennan FM, Feldmann M, Lacraz S, Miltenburg AMM, Welgus HG, Isler P, Vey E, Zhang JH, Ferrante A, Arrigo AP, Lieberman AP, Pitha PM, Shin HS, Shin ML, Chung IY, Benveniste EN, Sebire G and Emilie D (1995). Inhibitory cytokines and cytokine inhibitors. Neurology  vol. 45, (6) S39-S43. 10.1212/wnl.45.6_suppl_6.s39

1994

Miles DW, Happerfield LC, Naylor MS, Bobrow LG, Rubens RD and Balkwill FR (1994). Expression of tumour necrosis factor (TNF alpha) and its receptors in benign and malignant breast tissue. Int J Cancer  vol. 56, (6) 777-782. 10.1002/ijc.2910560603
Balkwill FR (1994). Cytokine therapy of cancer. The importance of knowing the context. European Cytokine Network  vol. 5, (4) 379-385.
Naylor MS, Stamp GW, Davies BD and Balkwill FR (1994). Expression and activity of MMPS and their regulators in ovarian cancer. International Journal of Cancer  vol. 58, (1) 50-56. 10.1002/ijc.2910580110
MILES D, THOMSEN L, BALKWILL F, THAVASU P and MONCADA S (1994). Association between biosynthesis of nitric oxide and changes in immunological and vascular parameters in patients treated with interleukin‐2. European Journal of Clinical Investigation  vol. 24, (4) 287-290. 10.1111/j.1365-2362.1994.tb01087.x
Thomas H and Balkwill FR (1994). Oncogene transgenic mice as therapeutic models in cancer research. European Journal of Cancer  vol. 30, (4) 533-537. 10.1016/0959-8049(94)90434-0

1993

Philip PA, Rea D, Thavasu P, Carmichael J, Stuart NSA, Rockett H, Talbot DC, Ganesan T, Pettit GR, Balkwill F and Harris AL (1993). Phase I study of bryostatin 1: Assessment of interleukin 6 and tumor necrosis factor α induction in vivo. Journal of The National Cancer Institute  vol. 85, (22) 1812-1818. 10.1093/jnci/85.22.1812
Davies B, Waxman J, Wasan H, Abel P, Williams G, Krausz T, Neal D, Thomas D, Hanby A and Balkwill F (1993). Levels of Matrix Metalloproteases in Bladder Cancer Correlate with Tumor Grade and Invasion. Cancer Research  vol. 53, (22) 5365-5369.
Burke F, Stuart Naylor M, Davies B and Balkwill F (1993). The cytokine wall chart. Trends in Immunology  vol. 14, (4) 10.1016/0167-5699(93)90280-x
Balkwill F (1993). Tumour necrosis factor. Improving on the formula. Nature  vol. 361, (6409) 206-207. 10.1038/361206a0
Davies B, Miles DW, Happerfield LC, Naylor MS, Bobrow LG, Rubens RD and Balkwill FR (1993). Activity of type IV collagenases in benign and malignant breast disease. British Journal of Cancer  vol. 67, (5) 1126-1131. 10.1038/bjc.1993.207
Taylor-Papadimitriou J and Balkwill F (1993). Fusion potential for vaccines. Nature  vol. 362, (6422) 10.1038/362695a0
Saraya KA and Balkwill FR (1993). Temporal sequence and cellular origin of interleukin-2 stimulated cytokine gene expression. British Journal of Cancer  vol. 67, (3) 514-521. 10.1038/bjc.1993.96
Davies B, Brown PD, East N, Crimmin MJ and Balkwill FR (1993). A Synthetic Matrix Metalloproteinase Inhibitor Decreases Tumor Burden and Prolongs Survival of Mice Bearing Human Ovarian Carcinoma Xenograft. Cancer Research  vol. 53, (9) 2087-2091.
Naylor MS, Stamp GWH, Foulkes WD, Eccles D and Balkwill FR (1993). Tumor necrosis factor and its receptors in human ovarian cancer: Potential role in disease progression. Journal of Clinical Investigation  vol. 91, (5) 2194-2206. 10.1172/JCI116446
Balkwill F (1993). Improving on the formula. Nature  vol. 361, (6409) 206-207. 10.1038/361206a0
Burke F, Stuart Naylor M, Davies B and Balkwill F (1993). The cytokine wall chart. Immunology Today  vol. 14, (4) 10.1016/0167-5699(93)90280-X
Burke F, Griffin D, Elwood N, Davis C, Stamp G, Rohatiner A, Lister TA and Balkwill F (1993). The effect of cytokines on cultured mononuclear cells from patients with B cell chronic lymphocytic leukemia. Hematological Oncology  vol. 11, (1) 23-33. 10.1002/hon.2900110104

1992

Thavasu PW, Longhurst S, Joel SP, Slevin ML and Balkwill FR (1992). Measuring cytokine levels in blood. Importance of anticoagulants, processing, and storage conditions. Journal of Immunological Methods  vol. 153, (1-2) 115-124. 10.1016/0022-1759(92)90313-I
Miles DW, Aderka D, Engelmann H, Wallach D and Balkwill FR (1992). Induction of soluble tumour necrosis factor receptors during treatment with interleukin-2. British Journal of Cancer  vol. 66, (6) 1195-1199. 10.1038/bjc.1992.435
Naylor MS, Stamp GW and Balkwill FR (1992). Beta actin expression and organization of actin filaments in colorectal neoplasia. Epithelial Cell Biology  vol. 1, (3) 99-104.
Balkwill FR (1992). Tumour necrosis factor and cancer. Progress in Growth Factor Research  vol. 4, (2) 121-137. 10.1016/0955-2235(92)90027-F
Malik ST and Balkwill FR (1992). Antiproliferative and antitumor activity of TNF in vitro and in vivo. Immunology Series  vol. 56, 239-268.
Malik TAS, East N, Boraschi D and Balkwill FR (1992). Effects of intraperitoneal recombinant interleukin-1β in intraperitoneal human ovarian cancer xenograft models: Comparison with the effects of tumour necrosis factor. British Journal of Cancer  vol. 65, (5) 661-666. 10.1038/bjc.1992.141

1991

Miles DW, Longhurst SJ, Harper PG and Balkwill FR (1991). Toxicity and reconstitution of recombinant interleukin-2 with albumin. The Lancet  vol. 338, (8780) 10.1016/0140-6736(91)92770-3
Kelly SA, Gschmeissner S, East N and Balkwill FR (1991). Enhancement of Metastatic Potential by γ-Interferon. Cancer Research  vol. 51, (15) 4020-4027.
Stanley LA, Adams DJ, Balkwill FR, Griffin D and Roland Wolf C (1991). Differential effects of recombinant interferon α on constitutive and inducible cytochrome P450 isozymes in mouse liver. Biochemical Pharmacology  vol. 42, (2) 311-320. 10.1016/0006-2952(91)90718-K
Thomas H and Balkwill FR (1991). Effects of interferons and other cytokines on tumors in animals: A review. Pharmacology and Therapeutics  vol. 52, (3) 307-330. 10.1016/0163-7258(91)90030-P
Malik STA, Knowles RG, East N, Lando D, Stamp G and Balkwill FR (1991). Antitumor Activity of -y-Interferon in Ascitic and Solid Tumor Models of Human Ovarian Cancer. Cancer Research  vol. 51, (24) 6643-6649.
Malik S and Balkwill F (1991). Epithelial ovarian cancer: A cytokine propelled disease? British Journal of Cancer  vol. 64, (4) 617-620. 10.1038/bjc.1991.372
Lagadec PF, Saraya KA and Balkwill FR (1991). Human small‐cell lung‐cancer cells are cytokine‐resistant but NK/LAK‐sensitive. International Journal of Cancer  vol. 48, (2) 311-317. 10.1002/ijc.2910480226
Malik STA, Martin D, Hart I and Balkwill F (1991). Therapy of human ovarian cancer xenografts with intraperitoneal liposome encapsulated muramyl-tripeptide phosphoethanolamine (MTP-PE) and recombinant GM-CSF. British Journal of Cancer  vol. 63, (3) 399-403. 10.1038/bjc.1991.92

1990

Naylor MS, Stamp GWH and Balkwill FR (1990). Investigation of Cytokine Gene Expression in Human Colorectal Cancer. Cancer Research  vol. 50, (14) 4436-4440.
Miles DW, Bird CR, Wadhwa M, Summerhayes M, Balkwill FR, Thorpe R and Rubens RD (1990). Reconstitution of interleukin 2 with albumin for infusion. The Lancet  vol. 335, (8705) 1602-1603. 10.1016/0140-6736(90)91439-H
Stuart Naylor M, Malik STA, Stamp GWH, Jobling T and Balkwill FR (1990). In situ detection of tumour necrosis factor in human ovarian cancer specimens. European Journal of Cancer and Clinical Oncology  vol. 26, (10) 1027-1030. 10.1016/0277-5379(90)90043-S
Malik STA, Stuart Naylor M, East N, Oliff A and Balkwill FR (1990). Cells secreting tumour necrosis factor show enhanced metastasis in nude mice. European Journal of Cancer and Clinical Oncology  vol. 26, (10) 1031-1034. 10.1016/0277-5379(90)90044-T
Balkwill FR, Stuart Naylor M and Malik S (1990). Tumour necrosis factor as an anticancer agent. European Journal of Cancer and Clinical Oncology  vol. 26, (5) 641-644. 10.1016/0277-5379(90)90097-D
Malik ST, Griffin DB, Naylor MS, Fiers W, Oliff A and Balkwill FR (1990). The complex effects of recombinant tumour necrosis factor-alpha (rhTNF-alpha) in human ovarian cancer xenograft models. Progress in Clinical and Biological Research  vol. 349, 393-403.

1989

Fiers W and Balkwill FR (1989). Future prospects and problems. Cancer Surveys  vol. 8, (4) 921-927.
Kelly SA, Malik STA and Balkwill FR (1989). The relevance of animal tumour models to the preclinical screening of cytokines. Cancer Surveys  vol. 8, (4) 741-754.
Stebbings WSL, Vinson GP, Farthing MJG, Balkwill F and Wood RFM (1989). Effect of steroid hormones on human colorectal adenocarcinoma xenografts, of known steroid-receptor status, in nude mice. Journal of Cancer Research and Clinical Oncology  vol. 115, (5) 439-444. 10.1007/BF00393333
Balkwill FR (1989). INTERFERONS. The Lancet  vol. 333, (8646) 1060-1063. 10.1016/S0140-6736(89)92455-0
Malik STA, Griffin DB, Fiers W and Balkwill FR (1989). Paradoxical effects of tumour necrosis factor in experimental ovarian cancer. International Journal of Cancer  vol. 44, (5) 918-925. 10.1002/ijc.2910440529
Balkwill FR, Griffin DB and Lee AE (1989). Interferons alpha and gamma differ in their ability to cause tumour stasis and regression in vivo. European Journal of Cancer and Clinical Oncology  vol. 25, (10) 1481-1486. 10.1016/0277-5379(89)90108-9
Balkwill FR and Burke F (1989). The cytokine network. Immunology Today  vol. 10, (9) 299-304. 10.1016/0167-5699(89)90085-6
Balkwill FR (1989). Tumour necrosis factor. British Medical Bulletin  vol. 45, (2) 389-400. 10.1093/oxfordjournals.bmb.a072330
Ramani P and Balkwill FR (1989). Action of recombinant alpha interferon against experimental and spontaneous metastases in a murine model. International Journal of Cancer  vol. 43, (1) 140-146. 10.1002/ijc.2910430126

1988

Balkwill F (1988). Cytokines - soluble factors in immune responses. Current Opinion in Immunology  vol. 1, (2) 241-249. 10.1016/0952-7915(88)90008-8
Ramani P and Balkwill FR (1988). Human interferons inhibit experimental metastases of a human melanoma cell line in nude mice. British Journal of Cancer  vol. 58, (3) 350-354. 10.1038/bjc.1988.217
Fentiman IS, Balkwill FR, Thomas BS, Russell MJ, Todd I and Bottazzo GF (1988). An autoimmune aetiology for hypothyroidism following interferon therapy for breast cancer. European Journal of Cancer and Clinical Oncology  vol. 24, (8) 1299-1303. 10.1016/0277-5379(88)90219-2
Malik S and Balkwill F (1988). The anti-cancer activity of tumour necrosis factor. Annales De L'Institut Pasteur. Immunology  vol. 139, (3) 285-288.
Malik S and Balkwill FR (1988). Tumour necrosis factor. British Medical Journal (Clinical Research Ed.)  vol. 296, (6631) 10.1136/bmj.296.6631.1214

1987

Fentiman IS, Balkwill FR, Cuzick J, Hayward JL and Rubens RD (1987). A trial of human alpha interferon as an adjuvant agent in breast cancer after loco-regional recurrence. European Journal of Surgical Oncology  vol. 13, (5) 425-428.
Balkwill F, Burke F, Talbot D, Tavernier J, Osborne R, Naylor S, Durbin H and Fiers W (1987). EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER. The Lancet  vol. 330, (8570) 1229-1232. 10.1016/S0140-6736(87)91850-2
Adams DJ, Balkwill FR, Griffin DB, Hayes JD, Lewis AD and Wolf CR (1987). Induction and suppression of glutathione transferases by interferon in the mouse. Journal of Biological Chemistry  vol. 262, (10) 4888-4892.
Balkwill FR and Smyth JF (1987). INTERFERONS IN CANCER THERAPY: A REAPPRAISAL. The Lancet  vol. 330, (8554) 317-319. 10.1016/S0140-6736(87)90901-9
Ward BG and Balkwill FR (1987). Intraperitoneal Xenografts of Human Epithelial Ovarian Cancer in Nude Mice. Cancer Research  vol. 47, (10) 2662-2667.
Ramani P and Balkwill FR (1987). Enhanced metastases of a mouse carcinoma after in vitro treatment with murine interferon gamma. International Journal of Cancer  vol. 40, (6) 830-834. 10.1002/ijc.2910400621
Tilles JG, Balkwill F and Davilla J (1987). 2′,5′-Oligoadenylate Synthetase and Interferon in Peripheral Blood after Rubella, Measles, or Mumps Live Virus Vaccine. Proceedings of The Society For Experimental Biology and Medicine  vol. 186, (1) 70-74. 10.3181/00379727-186-42586
Balkwill FR, Ward IBG, Moodie E and Fiers W (1987). Therapeutic Potential of Tumor Necrosis Factor-α and γ-Interferon in Experimental Human Ovarian Cancer. Cancer Research  vol. 47, (18) 4755-4758.
Smyth JF, Balkwill FR, Cavalli F, Kimchi A, Mattson K, Niederle NE and Spiegel RJ (1987). Interferons in oncology: Current status and future directions. European Journal of Cancer and Clinical Oncology  vol. 23, (6) 887-889. 10.1016/0277-5379(87)90298-7
Dealtry GB, Naylor MS, Fiers W and Balkwill FR (1987). The effect of recombinant human tumour necrosis factor on growth and macromolecular synthesis of human epithelial cells. Experimental Cell Research  vol. 170, (2) 428-438. 10.1016/0014-4827(87)90318-1
Dealtry GB, Naylor MS, Fiers W and Balkwill FR (1987). DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ. European Journal of Immunology  vol. 17, (5) 689-693. 10.1002/eji.1830170517
Balkwill FR, Ward BG and Fiers W (1987). Effects of tumour necrosis factor on human tumour xenografts in nude mice. Ciba Foundation Symposium  vol. 131, 154-169. 10.1002/9780470513521.ch11
Balkwill FR, Stevens MH, Griffin DB, Thomas JA and Bodmer JG (1987). Interferon gamma regulates HLA-D expression on solid tumors in vivo. European Journal of Cancer and Clinical Oncology  vol. 23, (1) 10.1016/0277-5379(87)90426-3

1986

Rowlinson G, Balkwill F, Snook D, Hooker G and Epenetos AA (1986). Enhancement by gamma-interferon of in vivo tumor radiolocalization by a monoclonal antibody against HLA-DR antigen. Cancer Res  vol. 46, (12 Pt 1) 6413-6417.
Balkwill FR (1986). Interferons: From molecular biology to man. Part 3. Interferons and disease. Microbiological Sciences  vol. 3, (9) 281-284.
Balkwill FR (1986). Interferons: From molecular biology to man. Part 2. Interferons and cell function. Microbiological Sciences  vol. 3, (8) 229-233.
Balkwill FR (1986). Interferons: From molecular biology to man. Part 1. Genetics and molecular biology of the interferon system. Microbiological Sciences  vol. 3, (7) 212-215.
Carmichael J, Fergusson RJ, Wolf CR, Balkwill FR and Smyth JF (1986). Augmentation of cytotoxicity of Chemotherapy by Human ɑ-Interferons in Human Non–Small Cell Lung Cancer Xenografts. Cancer Research  vol. 46, (10) 4916-4920.
Balkwill FR and Proietti E (1986). Effects of mouse interferon on human tumour xenografts in the nude mouse host. International Journal of Cancer  vol. 38, (3) 375-380. 10.1002/ijc.2910380312
Balkwill FR, Lee A, Aldam G, Moodie E, Thomas JA, Tavernier J and Fiers W (1986). Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons. Cancer Research  vol. 46, (8) 3990-3993.
Ramani P, Hart IR and Balkwill FR (1986). The effect of interferon on experimental metastases in immunocompetent and immunodeficient mice. International Journal of Cancer  vol. 37, (4) 563-568. 10.1002/ijc.2910370415
Balkwill FR (1986). Animal Models for Investigating Antitumor Effects of Interferon. Methods in Enzymology  vol. 119, (C) 649-657. 10.1016/0076-6879(86)19087-2

1985

Rohatiner AZ, Prior P, Burton A, Balkwill F and Lister TA (1985). Central nervous system toxicity of interferon. Progress in Experimental Tumor Research. Fortschritte Der Experimentellen Tumorforschung. Progres De La Recherche Experimentale  vol. 29, 197-202. 10.1159/000411640
Fentiman IS, Thomas BS, Balkwill FR, Rubens RD and Hayward JL (1985). PRIMARY HYPOTHYROIDISM ASSOCIATED WITH INTERFERON THERAPY OF BREAST CANCER. The Lancet  vol. 325, (8438) 10.1016/S0140-6736(85)92475-4
Taylor-Papadimitriou J, Balkwill F, Ebsworth N and Rozengurt E (1985). Antiviral and antiproliferative effects of interferons in quiescent fibroblasts are dissociable. Virology  vol. 147, (2) 405-412. 10.1016/0042-6822(85)90142-4
Balkwill FR, Goldstein L and Stebbing N (1985). Differential action of six human interferons against two human carcinomas growing in nude mice. International Journal of Cancer  vol. 35, (5) 613-617. 10.1002/ijc.2910350508
Bye A, Balkwill F, Brigden D and Wilson J (1985). USE OF INTERFERON IN THE MANAGEMENT OF PATIENTS WITH SUBACUTE SCLEROSING PANENCEPHALITIS. Developmental Medicine &Amp; Child Neurology  vol. 27, (2) 170-175. 10.1111/j.1469-8749.1985.tb03766.x
Padmanabhan N, Balkwill FR, Bodmer JG and Rubens RD (1985). Recombinant DNA human interferon alpha 2 in advanced breast cancer: A phase 2 trial. British Journal of Cancer  vol. 51, (1) 55-60. 10.1038/bjc.1985.8

1984

Shearer M, Taylor-Papadimitriou J, Griffin D and Balkwill F (1984). Monoclonal antibodies that distinguish between subspecies of human interferon-α and that detect interferon oligomers. Journal of Immunology  vol. 133, (6) 3096-3101.
Balkwill FR, Moodie EM, Griffin DB, Seilman SS, Wolf CR, Mowshowitz S and Fantes KH (1984). Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drug-metabolizing enzymes. Cancer Research  vol. 44, (11) 5249-5255.
Balkwill FR and Moodie EM (1984). Positive interactions between human interferon and cyclophosphamide or adriamycin in a human tumor model system. Cancer Research  vol. 44, (3) 904-908.
Borden EC and Balkwill FR (1984). Preclinical and clinical studies of interferons and interferon inducers in breast cancer. Cancer  vol. 53, (3 Suppl) 783-789. 10.1002/1097-0142(19840201)53:3+<783::aid-cncr2820531329>3.0.co;2-i
(1984). Differential effects of pure human alpha and gamma interferons on fibroblast cell growth and the cell cycle. Experimental Cell Research  vol. 155, (1) 190-197. 10.1016/0014-4827(84)90780-8
Borden EC and Balkwill FR (1984). Preclinical and clinical studies of interferons and interferon inducers in breast cancer. Cancer  vol. 53, (3 S) 783-789. 10.1002/1097-0142(19840201)53:3+<783::AID-CNCR2820531329>3.0.CO;2-I

1983

Balkwill FR, Griffin DB, Band HA and Beverley PCL (1983). Immune human lymphocytes produce an acid-labile α-interferon. Journal of Experimental Medicine  vol. 157, (3) 1059-1063. 10.1084/jem.157.3.1059
Rohatiner AZS, Prior PF, Burton AC, Smith AT, Balkwill FR and Lister TA (1983). Central nervous system toxicity of interferon. British Journal of Cancer  vol. 47, (3) 419-422. 10.1038/bjc.1983.63
Rohatiner AZS, Balkwill FR, Malpas JS and Lister TA (1983). Experience with human lymphoblastoid interferon in acute myelogenous leukaemia (AML). Cancer Chemotherapy and Pharmacology  vol. 11, (1) 56-58. 10.1007/BF00257419
Rohatiner AZ, Balkwill F and Lister TA (1983). Interferon in acute myelogenous leukaemia: a preliminary report. Haematology and Blood Transfusion  vol. 28, 56-58. 10.1007/978-3-642-68761-7_11
McCance DJ, Sebesteny A, Griffin BE, Balkwill F, Tilly R and Gregson NA (1983). A paralytic disease in nude mice associated with polyoma virus infection. Journal of General Virology  vol. 64, (1) 57-67. 10.1099/0022-1317-64-1-57
Balkwill FR, Moodie EM, Freedman V, Lane EB and Fantes KH (1983). An Animal Model System for Investigating the AntiTumor Effects of Human Interferon. Journal of Interferon Research  vol. 3, (3) 319-326. 10.1089/jir.1983.3.319

1982

Taylor-Papadimitriou J and Balkwill FR (1982). Implications for clinical application of new developments in interferon research. Bba - Reviews On Cancer  vol. 695, (1) 49-67. 10.1016/0304-419X(82)90006-3
Balkwill FR, Moodie EM, Freedman V and Fantes KH (1982). Human interferon inhibits the growth of established human breast tumours in the nude mouse. International Journal of Cancer  vol. 30, (2) 231-235. 10.1002/ijc.2910300217
SILVERMAN RH, WATLING D, BALKWILL FR, TROWSDALE J and KERR IM (1982). The ppp(A2′p)nA and Protein Kinase Systems in Wild‐Type and Interferon‐Resistant Daudi Cells. European Journal of Biochemistry  vol. 126, (2) 333-341. 10.1111/j.1432-1033.1982.tb06783.x
Taylor-Papadimitriou J, Shearer M, Balkwill FR and Fantes KH (1982). Effects of HuIFN-α2 and HuIFN-α (Namalwa) on Breast Cancer Cells Grown in Culture and as Xenografts in the Nude Mouse. Journal of Interferon Research  vol. 2, (4) 479-491. 10.1089/jir.1982.2.479
Rohatiner AZS, Balkwill FR, Griffin DB, Malpas JS and Lister TA (1982). A phase I study of human lymphoblastoid interferon administered by continuous intravenous infusion. Cancer Chemotherapy and Pharmacology  vol. 9, (2) 97-102. 10.1007/BF00265387

1981

Balkwill FH (1981). Extracts from the last century. Mechanical dentistry--on regulation cases by F.H. Balkwill. British Dental Journal  vol. 151, (1) 10.1038/sj.bdj.4804620
Rohatiner A, Balkwill F, Malpas JS and Lister TA (1981). A phase I study of human lymphoblastoid interferon in patients with hematological malignancies. Haematology and Blood Transfusion  vol. 26, 63-67. 10.1007/978-3-642-67984-1_9
Hogg N and Balkwill FR (1981). Species restriction in cytostatic activity of human and murine monocytes and macrophages. Immunology  vol. 43, (1) 197-204.
Rohatiner AZS, Balkwill F, Malpas JS and Lister TA (1981). A phase I study of intravenous human lymphoblastoid interferon (HLBI). Proceedings of The American Association For Cancer Research  vol. Vol. 22,

1980

Sebesteny A, Tilly R, Balkwill F and Trevan D (1980). Demyelination and wasting associated with polyomavirus infection in nude (nu/nu) mice. Laboratory Animals  vol. 14, (4) 337-345. 10.1258/002367780781071021
Balkwill F, Taylor-Papadimitriou J, Fantes KH and Sebesteny A (1980). Human lymphoblastoid interferon can inhibit the growth of human breast cancer xenografts in athymic (nude) mice. European Journal of Cancer (1965)  vol. 16, (4) 569-573. 10.1016/0014-2964(80)90237-6
Balkwill F, TaylorPapadimitriou J, Fantes KH and Sebesteny A (1980). HUMAN LYMPHOBLASTOID INTERFERON CAN INHIBIT THE GROWTH OF HUMAN BREAST CANCER XENOGRAFTS IN ATHYMIC [NUDE] MICE. Annals of The New York Academy of Sciences  vol. 350, (1) 591-592. 10.1111/j.1749-6632.1980.tb20671.x

1979

Balkwill FR and Hogg N (1979). Characterization of human breast milk macrophages cytostatic for human cell lines. Journal of Immunology  vol. 123, (4) 1451-1456.
Balkwill FR and Oliver RTD (1979). REMISSION IN ACUTE MYELOBLASTIC LEUKÆMIA. The Lancet  vol. 314, (8149) 961-962. 10.1016/S0140-6736(79)92658-8
Balkwill FR (1979). Interferons as cell-regulatory molecules. Cancer Immunology Immunotherapy  vol. 7, (1) 7-14. 10.1007/BF00205403

1978

Balkwill F and Taylor-Papadimitriou J (1978). Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth. Nature  vol. 274, (5673) 798-800. 10.1038/274798a0
Balkwill F, Watling D and TaylorPapadimitriou J (1978). Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast. International Journal of Cancer  vol. 22, (3) 258-265. 10.1002/ijc.2910220307

1977

Balkwill FR and Oliver RTD (1977). Growth inhibitory effects of interferon on normal and malignant human haemopoietic cells. International Journal of Cancer  vol. 20, (4) 500-505. 10.1002/ijc.2910200405
Balkwill FR, Franks CR, Oliver RTD and Spector WG (1977). Neoplastic macrophages grown from human leukaemic monocytes. The Journal of Pathology  vol. 122, (1) 13-26. 10.1002/path.1711220104
Franks CR, Bishop D, Balkwill FR, Oliver RTD and Spector WG (1977). Growth of acute myeloid leukaemia as discrete subcutaneous tumours in immune-deprived mice. British Journal of Cancer  vol. 35, (5) 697-700. 10.1038/bjc.1977.107

1976

Balkwill FR and Oliver RT (1976). Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia. British Journal of Cancer  vol. 33, (4) 400-410. 10.1038/bjc.1976.65
Balkwill FR and Oliver RTD (1976). Morphological characterisation of adult acute leukaemia in short term liquid culture. Recent Results in Cancer Research  vol. No.56, 87-90. 10.1007/978-3-642-81049-7_12

1974

Balkwill F, Pindar A and Crowther D (1974). Factors influencing microculture of leukaemia cells. Nature  vol. 251, (5477) 741-742. 10.1038/251741a0

Grants

Grants of specific relevance to Predictive in vitro Models
Role of JAM-C in inflammatory and vascular events in vivo as studied using an experimental model of ovarian cancer.
Nourshargh S and Balkwill FR
£227,807 Wellcome Trust (01-01-2010 - 31-12-2012)
Abstract