Prof Fran Balkwill
Deputy Lead, Centre for Tumour Microenvironment
Barts Cancer Institute
Faculty of Medicine and Dentistry, Queen Mary University of London
Faculty of Medicine and Dentistry, Queen Mary University of London
Research
cancer, tumour microenvironment, multi-cellular models, ovarian cancer, extracellular matrix, immunotherapy
Interests
The interest and experience of my laboratory relates to complex multi-cellular models MCMs of the tumour microenvironment, especially in ovarian cancer. Having completed a multi-level deconstruction of ovarian cancer metastases, we have begun to reconstruct 3D multi-cellular models of these metastases using primary adipocytes, fibroblasts, mesothelial cells, monocytes and malignant cells. We are also currently working to vascularise these MCMs. We are using the models to understand cell cell communication in the tumour microenvironment, test new biological therapies and study sensitivity and resistance to T cell killing.Publications
Publications of specific relevance to Predictive in vitro Models2023
Dibble M, Di Cio’ S, Luo P, Balkwill F and Gautrot JE (2023). The impact of pericytes on the stability of microvascular networks in response to nanoparticles. Scientific Reports vol. 13, (1) 10.1038/s41598-023-31352-xTsocheva I, Scales J, Dove R, Chavda J, Kalsi H, Wood HE, Colligan G, Cross L, Newby C, Hall A, Keating M, Sartori L, Moon J, Thomson A, Tomini F, Murray A, Hamad W, Tijm S, Hirst A, Vincent BP, Kotala P, Balkwill F, Mihaylova B, Grigg J, Quint JK, Fletcher M, Mon-Williams M, Wright J, van Sluijs E and Beevers S (2023). Investigating the impact of London’s ultra low emission zone on children’s health: children’s health in London and Luton (CHILL) protocol for a prospective parallel cohort study. Bmc Pediatrics vol. 23, (1) 10.1186/s12887-023-04384-5Mulvey KL, McGuire L, Mathews C, Hoffman AJ, Law F, Joy A, Hartstone-Rose A, Winterbottom M, Balkwill F, Fields G, Butler L, Burns K, Drews M and Rutland A (2023). Preparing the Next Generation for STEM: Adolescent Profiles Encompassing Math and Science Motivation and Interpersonal Skills and Their Associations With Identity and Belonging. Youth and Society vol. 55, (6) 1207-1230. 10.1177/0044118X221085296Scales J, Chavda J, Ikeda E, Tsocheva I, Dove RE, Wood HE, Kalsi H, Colligan G, Griffiths L, Day B, Crichlow C, Keighley A, Fletcher M, Newby C, Tomini F, Balkwill F, Mihaylova B, Grigg J, Beevers S, Eldridge S, Sheikh A, Gauderman J, Kelly F, Randhawa G, Mudway IS, van Sluijs E and Griffiths CJ (2023). Device-Measured Change in Physical Activity in Primary School Children During the UK COVID-19 Pandemic Lockdown: A Longitudinal Study. Journal of Physical Activity and Health vol. 20, (7) 639-647. 10.1123/jpah.2022-0434Phillips MM, Pavlyk I, Allen M, Ghazaly E, Cutts R, Carpentier J, Berry JS, Nattress C, Feng S, Hallden G, Chelala C, Bomalaski J, Steele J, Sheaff M, Balkwill F and Szlosarek PW (2023). A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma. Pharmacological Reports vol. 75, (3) 570-584. 10.1007/s43440-023-00480-6Phillips MM, Pavlyk I, Allen M, Ghazaly E, Cutts R, Carpentier J, Berry JS, Nattress C, Feng S, Hallden G, Chelala C, Bomalaski J, Steele J, Sheaff M, Balkwill F and Szlosarek PW (2023). Correction: A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma (Pharmacological Reports, (2023), 75, 3, (570-584), 10.1007/s43440-023-00480-6). Pharmacological Reports vol. 75, (3) 10.1007/s43440-023-00487-zJoy A, Mathews CJ, Zhao M, Law F, McGuire L, Hoffman AJ, Balkwill F, Burns KP, Butler L, Drews M, Fields G, Smith H, Ozturk E, Winterbottom M, Rutland A, Hartstone-Rose A and Mulvey KL (2023). Interest, Mindsets and Engagement: Longitudinal Relations in Science Orientations for Adolescents in Informal Science Programs. Journal of Youth and Adolescence vol. 52, (5) 1088-1099. 10.1007/s10964-023-01734-5Laforêts F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E and Balkwill F (2023). Semi-supervised analysis of myeloid and T cell behavior in ex vivo ovarian tumor slices reveals changes in cell motility after treatments. Iscience vol. 26, (4) 10.1016/j.isci.2023.106514Elorbany S, Berlato C, Carnevalli L, Maniati E, Wang J, Barry S, Manchanda R, Kzhyshkowska J and Balkwill F (2023). Abstract LB195: Immunotherapies that repolarize macrophages and CD4 T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer. American Association For Cancer Research (Aacr) Cancer Research vol. 83, (8_Supplement) lb195-lb195. 10.1158/1538-7445.am2023-lb195Kotantaki P, Laforêts F, Maniati E, Berlato C, Malliouri A, Devlin MJ, Malacrida B, Elorbany S, Manchanda R and Balkwill FR (2023). Abstract 5957: Chemotherapy-induced extracellular matrix remodeling in HGSOC. American Association For Cancer Research (Aacr) Cancer Research vol. 83, (7_Supplement) 5957-5957. 10.1158/1538-7445.am2023-5957Laforets F, Kotantaki P, Malacrida B, Elorbany S, Manchanda R, Donnadieu E and Balkwill F (2023). Abstract 5913: Semi-supervised analysis of myeloid and T cell behavior in ex vivo ovarian tumor slices reveals changes in cell motility after treatments. American Association For Cancer Research (Aacr) Cancer Research vol. 83, (7_Supplement) 5913-5913. 10.1158/1538-7445.am2023-5913Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F (2023). Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer. American Association For Cancer Research (Aacr) Cancer Research vol. 83, (7_Supplement) 4576-4576. 10.1158/1538-7445.am2023-4576Malacrida B, Elorbany S, Maniati E, Laforets F, Manchanda R and Balkwill FR (2023). Abstract 4551: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer: understanding the contribution of malignant cells. American Association For Cancer Research (Aacr) Cancer Research vol. 83, (7_Supplement) 4551-4551. 10.1158/1538-7445.am2023-4551Lloyd KE, Hall LH, Ziegler L, Foy R, Borthwick GM, MacKenzie M, Taylor DG, Smith SG, Cuzick J, Balkwill F, Bishop T, Burn J, Chan AT, Crooks C, Hawkey C, Langley R, Nedjai B, Patrignani P, Patrono C, Rocca B, Smith S and Greaves L (2023). GPs’ willingness to prescribe aspirin for cancer preventive therapy in Lynch syndrome: a factorial randomised trial investigating factors influencing decisions. British Journal of General Practice vol. 73, (729) E302-E309. 10.3399/BJGP.2021.0610Zhao M, Mathews CJ, Mulvey KL, Hartstone-Rose A, McGuire L, Hoffman AJ, Winterbottom M, Joy A, Law F, Balkwill F, Burns KP, Butler L, Drews M, Fields G, Smith H and Rutland A (2023). Promoting Diverse Youth’s Career Development through Informal Science Learning: The Role of Inclusivity and Belonging. Journal of Youth and Adolescence vol. 52, (2) 331-343. 10.1007/s10964-022-01694-2Elorbany S, Malacrida B and Balkwill F (2023). Interferon epsilon and ovarian cancer. Trends in Cancer 10.1016/j.trecan.2023.09.008McGuire L, Marlow C, Hoffman AJ, Joy A, Law F, Hartstone-Rose A, Rutland A, Winterbottom M, Balkwill F, Burns KP, Butler L, Fields G and Mulvey KL (2023). Children's and adolescents’ evaluations of wealth-related STEM inequality. Social Development 10.1111/sode.12710Zhao M, Ozturk E, Law F, Joy A, Deutsch AR, Marlow CS, Mathews CJ, McGuire L, Hoffman AJ, Balkwill F, Burns KP, Butler L, Drews M, Fields G, Smith H, Winterbottom M, Mulvey KL, Hartstone-Rose A and Rutland A (2023). Reciprocal Associations Between Science Efficacy, STEM Identity and Scientist Career Interest Among Adolescent Girls within the Context of Informal Science Learning. Journal of Youth and Adolescence 10.1007/s10964-023-01868-6Samain R, Maiques O, Monger J, Lam H, Candido J, George S, Ferrari N, Kohihammer L, Lunetto S, Varela A, Orgaz JL, Vilardell F, Olsina JJ, Matias-Guiu X, Sarker D, Biddle A, Balkwill FR, Eyles J, Wilkinson RW, Kocher HM, Calvo F, Wells CM and Sanz-Moreno V (2023). CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells. Science Advances vol. 9, (42) 10.1126/SCIADV.ADI02442022
Devlin MJ, Miller R, Laforets F, Kotantaki P, Garsed DW, Kristeleit R, Bowtell DD, McDermott J, Maniati E and Balkwill FR (2022). The Tumor Microenvironment of Clear-Cell Ovarian Cancer. Cancer Immunology Research vol. 10, (11) 1326-1339. 10.1158/2326-6066.CIR-22-0407McGuire L, Hoffman AJ, Mulvey KL, Hartstone-Rose A, Winterbottom M, Joy A, Law F, Balkwill F, Burns KP, Butler L, Drews M, Fields G, Smith H and Rutland A (2022). Gender Stereotypes and Peer Selection in STEM Domains Among Children and Adolescents. Sex Roles vol. 87, (9-10) 455-470. 10.1007/s11199-022-01327-9Olivera I, Sanz-Pamplona R, Bolaños E, Rodriguez I, Etxeberria I, Cirella A, Egea J, Garasa S, Migueliz I, Eguren-Santamaria I, Sanmamed MF, Glez-Vaz J, Azpilikueta A, Alvarez M, Ochoa MC, Malacrida B, Propper D, de Andrea CE, Berraondo P, Balkwill FR, Teijeira Á and Melero I (2022). A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα and IL-1β. Cancer Discovery vol. 12, (9) 2140-2157. 10.1158/2159-8290.CD-21-1115Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S, Athanasopoulos T, Ali S, Emery-Billcliff P, Ricciardelli I, Kay C, Colebrook J, Ali M, Strong K and Balkwill F (2022). Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer. American Association For Cancer Research (Aacr) Cancer Research vol. 82, (12_Supplement) 693-693. 10.1158/1538-7445.am2022-693Gopinathan G, Berlato C, Lakhani A, Szabova L, Pegrum C, Pedrosa AR, Laforets F, Maniati E and Balkwill FR (2022). Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer. Molecular Cancer Therapeutics vol. 21, (6) 1030-1045. 10.1158/1535-7163.MCT-21-0689Jangani M, Vuononvirta J, Yamani L, Ward E, Capasso M, Nadkarni S, Balkwill F and Marelli-Berg F (2022). Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators. Journal of Leukocyte Biology vol. 111, (5) 967-980. 10.1002/JLB.1A0920-588RCandarlioglu PL, Dal Negro G, Hughes D, Balkwill F, Harris K, Screen H, Morgan H, David R, Beken S, Guenat O, Rowan W and Amour A (2022). Organ-on-a-chip: current gaps and future directions. Portland Press Biochemical Society Transactions vol. 50, (2) 665-673. 10.1042/BST20200661Propper DJ and Balkwill FR (2022). Harnessing cytokines and chemokines for cancer therapy. Nature Reviews Clinical Oncology vol. 19, (4) 237-253. 10.1038/s41571-021-00588-9Malacrida B, Pearce OMT and Balkwill FR (2022). Building in vitro 3D human multicellular models of high-grade serous ovarian cancer. Star Protocols vol. 3, (1) 10.1016/j.xpro.2021.101086McGuire L, Hoffman AJ, Mulvey KL, Winterbottom M, Balkwill F, Burns KP, Chatton M, Drews M, Eaves N, Fields GE, Joy A, Law F, Rutland A and Hartstone-Rose A (2022). Impact of Youth and Adult Informal Science Educators on Youth Learning at Exhibits. Visitor Studies vol. 25, (1) 41-59. 10.1080/10645578.2021.19304672021
Leonard NA, Reidy E, Thompson K, McDermott E, Peerani E, Bort ET, Balkwill FR, Loessner D and Ryan AE (2021). Stromal cells promote matrix deposition, remodelling and an immunosuppressive tumour microenvironment in a 3d model of colon cancer. Cancers vol. 13, (23) 10.3390/cancers13235998Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C, Novak M, McDermott J, Brenton JD, Cutillas PR, Rajeeve V, Hennino A, Drapkin R, Loessner D and Balkwill FR (2021). Tgfbi production by macrophages contributes to an immunosuppressive microenvironment in ovarian cancer. Cancer Research vol. 81, (22) 5706-5719. 10.1158/0008-5472.CAN-21-0536Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT (2021). A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. Iscience vol. 24, (6) 10.1016/j.isci.2021.102676Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. Iscience vol. 24, (6) 10.1016/j.isci.2021.102674Heath O, Berlato C, Maniati E, Lakhani A, Pegrum C, Kotantaki P, Elorbany S, Bohm S, Barry ST, Annibaldi A, Barton DP and Balkwill FR (2021). Chemotherapy induces tumor-associated macrophages that aid adaptive immune responses in ovarian cancer. Cancer Immunology Research vol. 9, (6) 665-681. 10.1158/2326-6066.CIR-20-0968Balkwill FR (2021). Cells are Us – combining research and public engagement. Nature Reviews Cancer vol. 21, (5) 277-278. 10.1038/s41568-021-00349-xDelaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer., Editors: Balkwill F. Biorxiv.Org 10.1101/2021.02.01.428374Hoffman AJ, McGuire L, Rutland A, Hartstone-Rose A, Irvin MJ, Winterbottom M, Balkwill F, Fields GE and Mulvey KL (2021). The Relations and Role of Social Competencies and Belonging with Math and Science Interest and Efficacy for Adolescents in Informal STEM Programs. Journal of Youth and Adolescence vol. 50, (2) 314-323. 10.1007/s10964-020-01302-1Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O’Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H and van der Meer JWM (2021). Author Correction: A guiding map for inflammation (Nature Immunology, (2017), 18, 8, (826-831), 10.1038/ni.3790). Nature Immunology vol. 22, (2) 10.1038/s41590-020-00846-5Dreyer SB, Upstill-Goddard R, Paulus-Hock V, Paris C, Lampraki EM, Dray E, Serrels B, Caligiuri G, Rebus S, Plenker D, Galluzzo Z, Brunton H, Cunningham R, Tesson M, Nourse C, Bailey UM, Jones MD, Moran-Jones K, Wright DW, Duthie F, Oien K, Evers L, McKay CJ, McGregor GA, Gulati A, Brough R, Bajrami I, Pettitt S, Dziubinski ML and Candido J (2021). Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer. Gastroenterology vol. 160, (1) 362-377.e13. 10.1053/j.gastro.2020.09.043Delvecchio FR, Fincham REA, Spear S, Clear A, Roy-Luzarraga M, Balkwill FR, Gribben JG, Bombardieri M, Hodivala-Dilke K, Capasso M and Kocher HM (2021). Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice. Cellular and Molecular Gastroenterology and Hepatology vol. 12, (5) 1543-1565. 10.1016/j.jcmgh.2021.06.0232020
Mcclelland S, Tamura N, Shaikh N, Muliaditan D, Soliman T, McGuinness J, Maniati E, Moralli D, Durin M-A, Green C, Balkwill F, Wang J and Curtius K (2020). Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma. American Association For Cancer Research Cancer Research 10.1158/0008-5472.CAN-19-0852Marques P, Barry S, Carlsen E, Collier D, Ronaldson A, Awad S, Mendoza N, Muquit S, Dorward N, Grieve J, Balkwill F, Grossman AB and Korbonits M (2020). The role of the tumour microenvironment in pituitary adenoma angiogenesis. Bioscientifica Endocrine Abstracts 10.1530/endoabs.70.oc7.2Balkwill FR (2020). A darker side to retinoic acid revealed by sarcomas. New England Journal of Medicine vol. 383, (5) 491-493. 10.1056/NEJMcibr2005538Mulvey KL, McGuire L, Hoffma AJ, Goff E, Rutland A, Winterbottom M, Balkwill F, Irvi MJ, Field GE, Burns K, Drews M, Law F, Joy A and Hartstone-Rose A (2020). Interest and learning in informal science learning sites: Differences in experiences with different types of educators. Plos One vol. 15, (7 July) 10.1371/journal.pone.0236279Mulvey KL, McGuire L, Hoffman AJ, Hartstone-Rose A, Winterbottom M, Balkwill F, Fields GE, Burns K, Drews M, Chatton M, Eaves N, Law F, Joy A and Rutland A (2020). Learning hand in hand: Engaging in research–practice partnerships to advance developmental science. New Directions For Child and Adolescent Development vol. 2020, (172) 125-134. 10.1002/cad.20364Whitehouse AL, Mushtaq N, Miyashita L, Barratt B, Khan A, Kalsi H, Koh L, Padovan MG, Brugha R, Balkwill FR, Stagg AJ and Grigg J (2020). Airway dendritic cell maturation in children exposed to air pollution. Public Library of Science (Plos) Plos One vol. 15, (5) e0232040-e0232040. 10.1371/journal.pone.0232040Montfort A, Owen S, Piskorz AM, Supernat A, Moore L, Al-Khalidi S, Böhm S, Pharoah P, McDermott J, Balkwill FR and Brenton JD (2020). Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma. Springer Nature [Academic Journals On Nature.Com] British Journal of Cancer 10.1038/s41416-020-0822-xDemircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker A-M, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Balkwill FR, Sosabowski J, Cutillas PR, Frezza C, Sancho P and Hodivala-Dilke K (2020). Cancer associated fibroblast FAK regulates malignant cell metabolism. Nature Research (Part of Springer Nature) Nature Communications vol. 11, (1) 1290-1290. 10.1038/s41467-020-15104-3Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joyce JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill F (2020). Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Elsevier Bv Ssrn Electronic Journal 10.2139/ssrn.34112532019
Marques P, Barry S, Carlsen E, Collier D, Ronaldson A, Awad S, Dorward N, Grieve J, Mendoza N, Muquit S, Grossman AB, Balkwill F and Korbonits M (2019). Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours. Acta Neuropathologica Communications vol. 7, (1) 10.1186/s40478-019-0830-3Marques P, Barry S, Carlsen E, Collier D, Ronaldson A, Awad S, Mendoza N, Dorward N, Grieve J, Balkwill F and Korbonits M (2019). Pituitary tumour-derived chemokines modulate immune cell infiltrates in the tumour microenvironment leading to aggressive phenotype. Bioscientifica Endocrine Abstracts 10.1530/endoabs.63.oc13.3Marques P, Barry S, Carlsen E, Collier D, Ronaldson A, Awad S, Dorward N, Grieve J, Balkwill F and Korbonits M (2019). MON-462 Cytokine Network in Pituitary Adenomas and Its Role in the Tumor Microenvironment: Focus on Macrophages. The Endocrine Society Journal of The Endocrine Society vol. 3, (Suppl 1) mon-462. 10.1210/js.2019-mon-462Marques P, Barry S, Carlsen E, Collier D, Ronaldson A, Awad S, Dorward N, Grieve J, Balkwill F and Korbonits M (2019). MON-460 Pasireotide Treatment Inhibits Cytokine Release from Pituitary Adenoma-Associated Fibroblasts: Is This Mechanism Playing a Key Role in Its Effect? The Endocrine Society Journal of The Endocrine Society vol. 3, (Suppl 1) mon-460. 10.1210/js.2019-mon-460Bast RC, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z and Mills GB (2019). Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer vol. 125, (12) 1963-1972. 10.1002/cncr.32004Spear S, Candido JB, McDermott JR, Ghirelli C, Maniati E, Beers SA, Balkwill FR, Kocher HM and Capasso M (2019). Discrepancies in the tumor microenvironment of spontaneous and orthotopic murine models of pancreatic cancer uncover a new immunostimulatory phenotype for B cells. Frontiers Media Frontiers in Immunology vol. 10, (MAR) 10.3389/fimmu.2019.00542Marques P, Barry S, Carlsen E, Collier D, Ronaldson A, Awad S, Dorward N, Grieve J, Mendoza N, Muquit S, Grossman AB, Balkwill F and Korbonits M (2019). Pituitary tumour fibroblast-derived cytokines influence tumour aggressiveness. Endocrine-Related Cancer vol. 26, (12) 853-865. 10.1530/ERC-19-03272018
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR and Hynes RO (2018). Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. Journal of Proteome Research vol. 16, (8) 3083-3091. 10.1021/acs.jproteome.7b00191Sanz-Moreno V and Balkwill FR (2018). Mets and NETs: The Awakening Force. Immunity vol. 49, (5) 798-800. 10.1016/j.immuni.2018.11.009Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A, Clark W, McGhee EJ, Wang J, Escorcio-Correia M, Zollinger R, Roshani R, Drew L, Rishi L, Arkell R, Evans TRJ, Nixon C, Jodrell DI, Wilkinson RW, Biankin AV, Barry ST, Balkwill FR and Sansom OJ (2018). CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype. Cell Reports vol. 23, (5) 1448-1460. 10.1016/j.celrep.2018.03.131Malik STA and Balkwill FR (2018). Cytokines. The Nude Mouse in Oncology Research 10.1201/97813510772172017
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov 10.1158/2159-8290.CD-17-0284Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H and van der Meer JWM (2017). A guiding map for inflammation. Nat Immunol vol. 18, (8) 826-831. 10.1038/ni.3790BALKWILL F, Berlato C, Khan MN, Schioppa T, Thompson R, Maniati E, Montfort A, Jangani M, Canosa M, Kulbe H, Hagemann U, Duncan A, Fletcher L, Wilkinson RW, Powles T and Quezada S (2017). A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer. American Society For Clinical Investigation Journal of Clinical Investigation 10.1172/JCI829762016
Walton J, Blagih J, Ennis D, Leung E, Dowson S, Farquharson M, Tookman LA, Orange C, Athineos D, Mason S, Stevenson D, Blyth K, Strathdee D, Balkwill FR, Vousden KH, Lockley M and McNeish IA (2016). CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma. American Association For Cancer Research Cancer Research 10.1158/0008-5472.CAN-16-1272Delaine-Smith RM, Burney S, Balkwill FR and Knight MM (2016). Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics. Elsevier Journal of The Mechanical Behavior of Biomedical Materials vol. 60, 401-415. 10.1016/j.jmbbm.2016.02.019Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M and Balkwill FR (2016). A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases. American Association For Cancer Research Clinical Cancer Research 10.1158/1078-0432.CCR-16-0081Steele CW, Karim SA, Leach JDG, Bailey P, Upstill-Goddard R, Rishi L, Foth M, Bryson S, McDaid K, Wilson Z, Eberlein C, Candido JB, Clarke M, Nixon C, Connelly J, Jamieson N, Carter CR, Balkwill F, Chang DK, Evans TRJ, Strathdee D, Biankin AV, Nibbs RJB, Barry ST, Sansom OJ and Morton JP (2016). CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma. Elsevier (Cell Press) Cancer Cell vol. 29, (6) 832-845. 10.1016/j.ccell.2016.04.014GROSE RP, Dawkins JBN, Wang J, maniati , heward , koniali , kocher , martin , chelala , balkwill and fitzgibbon (2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. American Association For Cancer Research Cancer Research 10.1158/0008-5472.CAN-16-0481BALKWILL F, Anne Montfort and Oliver Pearce (2016). Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma. American Association For Cancer Research Clinical Cancer Research 10.1158/1078-0432.CCR-15-2657Kulbe H, Iorio F, Chakravarty P, Milagre CS, Moore R, Thompson RG, Everitt G, Canosa M, Montoya A, Drygin D, Braicu I, Sehouli J, Saez-Rodriguez J, Cutillas PR and Balkwill FR (2016). Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells. Oncotarget vol. 7, (13) 15648-15661. 10.18632/oncotarget.7255Walton J, Dowson S, Ennis D, Leung E, Farquharson M, Stevenson D, Blyth K, Strathdee D, Balkwill FR, Lockley M and McNeish IA (2016). Abstract B53: CRISPR/Cas9 mediated p53 and BRCA2 knockout to generate improved murine models of high grade serous ovarian cancer. American Association For Cancer Research (Aacr) Clinical Cancer Research vol. 22, (2_Supplement) b53-b53. 10.1158/1557-3265.ovca15-b532015
Crusz SM and Balkwill FR (2015). Inflammation and cancer: Advances and new agents. Nature Reviews Clinical Oncology vol. 12, (10) 584-596. 10.1038/nrclinonc.2015.105Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, Edmondson R, Fotopoulou C, Gabra H, Galon J, Gourley C, Heong V, Huntsman DG, Iwanicki M, Karlan BY, Kaye A, Lengyel E, Levine DA, Lu KH, McNeish IA and Menon U (2015). Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer. Nature Reviews Cancer vol. 15, (11) 668-679. 10.1038/nrc4019Balkwill F and Chambers K (2015). Centre of the Cell: Science Comes to Life. Plos Biology vol. 13, (9) 10.1371/journal.pbio.1002240Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Interleukin-6 stimulates defective angiogenesis. Cancer Research vol. 75, (15) 3098-3107. 10.1158/0008-5472.CAN-15-1227Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Abstract 4162: Interleukin–6 stimulates defective angiogenesis. American Association For Cancer Research (Aacr) 10.1158/1538-7445.am2015-4162Milagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R, Bowtell DDL, Hochhauser D and Balkwill FR (2015). Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL6 antibodies, with implications for combined therapy in ovarian cancer. Cancer Research vol. 75, (7) 1255-1264. 10.1158/0008-5472.CAN-14-1801Balkwill F (2015). Targeting inflammatory cytokines in cancer. Clinical & Experimental Metastasis vol. 32, (3) 183-183. 2014
Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ and Silva-Santos B (2014). Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A vol. 111, (34) E3562-E3570. 10.1073/pnas.1403424111Balkwill F (2014). 33: Targeting cancer-related inflammation. Elsevier European Journal of Cancer vol. 50, 10.1016/s0959-8049(14)50033-0Karin M, Jobin C and Balkwill F (2014). Chemotherapy, immunity and microbiota--a new triumvirate? Nat Med vol. 20, (2) 126-127. 10.1038/nm.3473Lau T-S, Chung TK-H, Cheung T-H, Chan LK-Y, Cheung LW-H, Yim S-F, Siu NS-S, Lo K-W, Yu MM-Y, Kulbe H, Balkwill FR and Kwong J (2014). Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts. J Pathol vol. 232, (1) 43-56. 10.1002/path.42582013
Whilding LM, Archibald KM, Kulbe H, Balkwill FR, Öberg D and McNeish IA (2013). Vaccinia virus induces programmed necrosis in ovarian cancer cells. Mol Ther vol. 21, (11) 2074-2086. 10.1038/mt.2013.195Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T, Imhof BA, Balkwill FR and Nourshargh S (2013). Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. Faseb J vol. 27, (10) 4244-4253. 10.1096/fj.13-230441Balkwill F, Montfort A and Capasso M (2013). B regulatory cells in cancer. Trends Immunol vol. 34, (4) 169-173. 10.1016/j.it.2012.10.007Sandhu SK, Papadopoulos K, Fong PC, Patnaik A, Messiou C, Olmos D, Wang G, Tromp BJ, Puchalski TA, Balkwill F, Berns B, Seetharam S, de Bono JS and Tolcher AW (2013). A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors. Cancer Chemother Pharmacol vol. 71, (4) 1041-1050. 10.1007/s00280-013-2099-82012
Balkwill FR, Capasso M and Hagemann T (2012). The tumor microenvironment at a glance. J Cell Sci vol. 125, (Pt 23) 5591-5596. 10.1242/jcs.116392Archibald KM, Kulbe H, Kwong J, Chakravarty P, Temple J, Chaplin T, Flak MB, McNeish IA, Deen S, Brenton JD, Young BD and Balkwill F (2012). Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium. Oncogene vol. 31, (48) 4987-4995. 10.1038/onc.2011.653Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and Balkwill FR (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol vol. 227, (2) 136-145. 10.1002/path.4002Affara NI, Ruffell B, Johansson M, Fujikawa K, Bergsland E, DeNardo DG, Chen HI, Wadhwani N, Steinhoff M, Truitt M, Olson P, Hanahan D, Li Y, Gong Q, Ma Y, Wiesen JF, Kim G, Tempero M, Balkwill F, Irving B and Coussens LM (2012). Abstract 4391: CD20 as a target for therapy in solid tumors. American Association For Cancer Research (Aacr) Cancer Research vol. 72, (8_Supplement) 4391-4391. 10.1158/1538-7445.am2012-4391Kulbe H, Chakravarty P, Moore R, Iorio F, Montoya A, Saez-Rodriguez J, Cutillas P and Balkwill F (2012). Abstract 49: Targeting the TNF network in human ovarian cancer - A systems biology approach. American Association For Cancer Research (Aacr) Cancer Research vol. 72, (8_Supplement) 49-49. 10.1158/1538-7445.am2012-49Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupairmoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Hu W, Gershenson H, Matsuo K, Shahzad MMK, King ER, Tekedereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Lamkin D, Collins K, DeGeest K and Lutgendorf SK (2012). Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med vol. 366, (7) 610-618. 10.1056/NEJMoa1110352Balkwill FR and Mantovani A (2012). Cancer-related inflammation: common themes and therapeutic opportunities. Semin Cancer Biol vol. 22, (1) 33-40. 10.1016/j.semcancer.2011.12.005Balkwill FR (2012). The chemokine system and cancer. J Pathol vol. 226, (2) 148-157. 10.1002/path.3029Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Australian Ovarian Cancer Study Group , Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD and Balkwill FR (2012). A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res vol. 72, (1) 66-75. 10.1158/0008-5472.CAN-11-21782011
Balkwill FR, Coward J, Kulbe H, Milagre C, Gopinathan G and McNeish IA (2011). IL-6 and ovarian cancer--response. Clin Cancer Res vol. 17, (24) 10.1158/1078-0432.CCR-11-2680Maniati E, Bossard M, Cook N, Candido JB, Emami-Shahri N, Nedospasov SA, Balkwill FR, Tuveson DA and Hagemann T (2011). Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J Clin Invest vol. 121, (12) 4685-4699. 10.1172/JCI45797Balkwill F (2011). The inflammatory tissue microenvironment and the early stages of malignancy. Pre-Invasive Disease: Pathogenesis and Clinical Management 10.1007/978-1-4419-6694-0_2Coward J and Balkwill F (2011). Targeting inflammatory pathways in epithelial ovarian cancer. Emerging Therapeutic Targets in Ovarian Cancer 10.1007/978-1-4419-7216-3_7Vaughan S, Coward JI, Bast RC, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, Friedlander M, Gabra H, Kaye SB, Lord CJ, Lengyel E, Levine DA, McNeish IA, Menon U, Mills GB, Nephew KP, Oza AM, Sood AK, Stronach EA, Walczak H, Bowtell DD and Balkwill FR (2011). Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer vol. 11, (10) 719-725. 10.1038/nrc3144Coward J, Kulbe H, Chakravarty P, Leader D, Vassileva V, Leinster DA, Thompson R, Schioppa T, Nemeth J, Vermeulen J, Singh N, Avril N, Cummings J, Rexhepaj E, Jirström K, Gallagher WM, Brennan DJ, McNeish IA and Balkwill FR (2011). Interleukin-6 as a therapeutic target in human ovarian cancer. Clin Cancer Res vol. 17, (18) 6083-6096. 10.1158/1078-0432.CCR-11-0945Balkwill F, Whitehead S, Willis P, Gaymond N, Kent A, Page C, Lovell-Badge R, Morris R, Lemon R and Banks D (2011). Safety of medicines and the use of animals in research. Lancet vol. 378, (9786) 127-128. 10.1016/S0140-6736(11)60984-7Schioppa T, Moore R, Thompson RG, Rosser EC, Kulbe H, Nedospasov S, Mauri C, Coussens LM and Balkwill FR (2011). B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis. Proc Natl Acad Sci U S A vol. 108, (26) 10662-10667. 10.1073/pnas.1100994108Allan S and Balkwill F (2011). Translating science in more ways than one: an interview with Frances Balkwill. Dis Model Mech vol. 4, (3) 286-288. 10.1242/dmm.007898Karlsen TH and Kaser A (2011). Deciphering the genetic predisposition to primary sclerosing cholangitis. Semin Liver Dis vol. 31, (2) 188-207. 10.1055/s-0031-1276647Anglesio MS, George J, Kulbe H, Friedlander M, Rischin D, Lemech C, Power J, Coward J, Cowin PA, House CM, Chakravarty P, Gorringe KL, Campbell IG, Australian Ovarian Cancer Study Group , Okamoto A, Birrer MJ, Huntsman DG, de Fazio A, Kalloger SE, Balkwill F, Gilks CB and Bowtell DD (2011). IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Clin Cancer Res vol. 17, (8) 2538-2548. 10.1158/1078-0432.CCR-10-3314Salako MA, Kulbe H, Ingemarsdotter CK, Pirlo KJ, Williams SL, Lockley M, Balkwill FR and McNeish IA (2011). Inhibition of the inflammatory cytokine TNF-α increases adenovirus activity in ovarian cancer via modulation of cIAP1/2 expression. Mol Ther vol. 19, (3) 490-499. 10.1038/mt.2010.2472010
Balkwill F and Joffroy C (2010). TNF: a tumor-suppressing factor or a tumor-promoting factor? Future Oncol vol. 6, (12) 1833-1836. 10.2217/fon.10.155Flak MB, Connell CM, Chelala C, Archibald K, Salako MA, Pirlo KJ, Lockley M, Wheatley SP, Balkwill FR and McNeish IA (2010). p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker. Mol Cancer vol. 9, 10.1186/1476-4598-9-175Toulza F, Nosaka K, Tanaka Y, Schioppa T, Balkwill F, Taylor GP and Bangham CRM (2010). Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells. J Immunol vol. 185, (1) 183-189. 10.4049/jimmunol.0903846Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DAH, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA and Committee of the National Cancer Research Institute (2010). Guidelines for the welfare and use of animals in cancer research. Br J Cancer vol. 102, (11) 1555-1577. 10.1038/sj.bjc.6605642Balkwill F and Mantovani A (2010). Cancer and inflammation: implications for pharmacology and therapeutics. Clin Pharmacol Ther vol. 87, (4) 401-406. 10.1038/clpt.2009.312Saadi A, Shannon NB, Lao-Sirieix P, O'Donovan M, Walker E, Clemons NJ, Hardwick JS, Zhang C, Das M, Save V, Novelli M, Balkwill F and Fitzgerald RC (2010). Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers. Proc Natl Acad Sci U S A vol. 107, (5) 2177-2182. 10.1073/pnas.0909797107Balkwill F and Mantovani A (2010). Foreword. Cytokine Growth Factor Rev vol. 21, (1) 10.1016/j.cytogfr.2009.11.0042009
Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A, Chakravarty P, Thompson RG, Kollias G, Smyth JF, Balkwill FR and Hagemann T (2009). The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J Clin Invest vol. 119, (10) 3011-3023. 10.1172/JCI39065Kwong J, Kulbe H, Wong D, Chakravarty P and Balkwill F (2009). An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther vol. 8, (7) 1893-1905. 10.1158/1535-7163.MCT-08-0966Kwong J, Chan FL, Wong K-K, Birrer MJ, Archibald KM, Balkwill FR, Berkowitz RS and Mok SC (2009). Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells. Neoplasia vol. 11, (6) 529-541. 10.1593/neo.09112Balkwill F (2009). Tumour necrosis factor and cancer. Nat Rev Cancer vol. 9, (5) 361-371. 10.1038/nrc2628Li NF, Kocher HM, Salako MA, Obermueller E, Sandle J and Balkwill F (2009). A novel function of colony-stimulating factor 1 receptor in hTERT immortalization of human epithelial cells. Oncogene vol. 28, (5) 773-780. 10.1038/onc.2008.412Archibald K, Kwong J, Kulbe H, Young B and Balkwill F (2009). Spontaneously transformed hTERT immortalized human ovarian surface epithelial cells have a functional amplification of the CXCR4 gene locus. Cancer Research vol. 69, Coward J, Quigley M, Leader D, Berns B, Balkwill F and McNeish I (2009). A Phase II study of intravenous CNT0328 in patients with recurrent epithelial ovarian cancer. Cancer Research vol. 69, Schioppa T, Moore R, Thompson R, de Visser K, Coussens L and Balkwill F (2009). Role of B cell in two-stage skin carcinogenesis. Cancer Research vol. 69, 2008
Mantovani A, Allavena P, Sica A and Balkwill F (2008). Cancer-related inflammation. Nature vol. 454, (7203) 436-444. 10.1038/nature07205Brown ER, Charles KA, Hoare SA, Rye RL, Jodrell DI, Aird RE, Vora R, Prabhakar U, Nakada M, Corringham RE, DeWitte M, Sturgeon C, Propper D, Balkwill FR and Smyth JF (2008). A clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancer. Ann Oncol vol. 19, (7) 1340-1346. 10.1093/annonc/mdn054Hagemann T, Lawrence T, McNeish I, Charles KA, Kulbe H, Thompson RG, Robinson SC and Balkwill FR (2008). Re-educating tumor-associated macrophages by targeting NF-kappaB. J Exp Med vol. 205, (6) 1261-1268. 10.1084/jem.20080108Ashworth A, Balkwill F, Bast RC, Berek JS, Kaye A, Boyd JA, Mills G, Weinstein JN, Woolley K and Workman P (2008). Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007. Gynecol Oncol vol. 108, (3) 652-657. 10.1016/j.ygyno.2007.11.014Karagiannis SN, Bracher MG, Beavil RL, Beavil AJ, Hunt J, McCloskey N, Thompson RG, East N, Burke F, Sutton BJ, Dombrowicz D, Balkwill FR and Gould HJ (2008). Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells. Cancer Immunol Immun vol. 57, (2) 247-263. 10.1007/s00262-007-0371-72007
Li NF, Broad S, Lu YJ, Yang JS, Watson R, Hagemann T, Wilbanks G, Jacobs I, Balkwill F, Dafou D and Gayther SA (2007). Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression. Cell Prolif vol. 40, (5) 780-794. 10.1111/j.1365-2184.2007.00462.xHagemann T, Balkwill F and Lawrence T (2007). Inflammation and cancer: A double-edged sword. Cancer Cell vol. 12, (4) 300-301. 10.1016/j.ccr.2007.10.005Karagiannis SN, Bracher MG, Hunt J, McCloskey N, Beavil RL, Beavil AJ, Fear DJ, Thompson RG, East N, Burke F, Moore RJ, Dombrowicz DD, Balkwill FR and Gould HJ (2007). IgE-antibody-dependent immunotherapy of solid tumors: Cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells. J Immunol vol. 179, (5) 2832-2843. 10.4049/jimmunol.179.5.2832Lawrence T, Hageman T and Balkwill F (2007). Cancer. Sex, cytokines, and cancer. Science vol. 317, (5834) 51-52. 10.1126/science.1146052Szlosarek PW, Grimshaw MJ, Wilbanks GD, Hagemann T, Wilson JL, Burke F, Stamp G and Balkwill FR (2007). Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer. Int J Cancer vol. 121, (1) 6-11. 10.1002/ijc.22666Hagemann T, Robinson SC, Thompson RG, Charles K, Kulbe H and Balkwill FR (2007). Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis. Mol Cancer Ther vol. 6, (7) 1993-2002. 10.1158/1535-7163.MCT-07-0118Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, Gould D, Ayhan A and Balkwill F (2007). The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res vol. 67, (2) 585-592. 10.1158/0008-5472.CAN-06-29412006
Szlosarek PW, Klabatsa A, Pallaska A, Sheaff M, Smith P, Crook T, Grimshaw MJ, Steele JP, Rudd RM, Balkwill FR and Fennell DA (2006). In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion. Clin Cancer Res vol. 12, (23) 7126-7131. 10.1158/1078-0432.CCR-06-1101Mantovani A and Balkwill F (2006). RaIB signaling: A bridge between inflammation and cancer. Cell vol. 127, (1) 42-44. 10.1016/j.cell.2006.09.019Balkwill F (2006). TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev vol. 25, (3) 409-416. 10.1007/s10555-006-9005-3Strauss SJ, Maharaj L, Hoare S, Johnson PW, Radford JA, Vinnecombe S, Millard L, Rohatiner A, Boral A, Trehu E, Schenkein D, Balkwill F, Joel SP and Lister TA (2006). Bortezomib therapy in patients with relapsed or refractory lymphoma: potential correlation of in vitro sensitivity and tumor necrosis factor alpha response with clinical activity. J Clin Oncol vol. 24, (13) 2105-2112. 10.1200/JCO.2005.04.6789Hagemann T, Wilson J, Burke F, Kulbe H, Li NF, Pluddemann A, Charles K, Gordon S and Balkwill FR (2006). Ovarian cancer cells polarize macrophages towards a tumor-associated phenotype. Med Klin vol. 101, (4) A44-A44. Hagemann T, Wilson J, Burke F, Kulbe H, Li NF, Plüddemann A, Charles K, Gordon S and Balkwill FR (2006). Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol vol. 176, (8) 5023-5032. 10.4049/jimmunol.176.8.5023Balkwill F (2006). Cancer and inflammation. Eur J Cancer vol. 42, (6) 689-690. 10.1016/j.ejca.2006.03.002Szlosarek P, Charles KA and Balkwill FR (2006). Tumour necrosis factor-alpha as a tumour promoter. Eur J Cancer vol. 42, (6) 745-750. 10.1016/j.ejca.2006.01.012Balkwill FR, Ashworth A, Bast RC, Berek JS, Boyd J, Disis ML, Gabra H, Gore ME, Hamilton TC, Jacobs IJ, Kaye SB, Kohn EC, Mills GB and Urban ND (2006). 10th Biennial Helene Harris Memorial Trust meeting. Cancer Res vol. 66, (6) 2904-2906. 10.1158/0008-5472.CAN-05-2093Balkwill F (2006). Inflammation: a double-edged sword. Eur J Cancer vol. 42, (5) 571-571. Szlosarek PW, Grimshaw MJ, Kulbe H, Wilson JL, Wilbanks GD, Burke F and Balkwill FR (2006). Expression and regulation of tumor necrosis factor alpha in normal and malignant ovarian epithelium. Mol Cancer Ther vol. 5, (2) 382-390. 10.1158/1535-7163.MCT-05-03032005
Balkwill F (2005). Book Review. Massachusetts Medical Society New England Journal of Medicine vol. 353, (22) 2413-2414. 10.1056/nejm200512013532222Kulbe H, Hagemann T, Szlosarek PW, Balkwill FR and Wilson JL (2005). The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells. Cancer Res vol. 65, (22) 10355-10362. 10.1158/0008-5472.CAN-05-0957Hagemann T and Balkwill F (2005). MIFed about cancer? Gastroenterology vol. 129, (5) 1785-1787. 10.1053/j.gastro.2005.09.039Madhusudan S, Muthuramalingam SR, Braybrooke JP, Wilner S, Kaur K, Han C, Hoare S, Balkwill F and Ganesan TS (2005). Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer. J Clin Oncol vol. 23, (25) 5950-5959. 10.1200/JCO.2005.04.127Hagemann T, Wilson J, Kulbe H, Li NF, Leinster DA, Charles K, Klemm F, Pukrop T, Binder C and Balkwill FR (2005). Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J Immunol vol. 175, (2) 1197-1205. 10.4049/jimmunol.175.2.1197Barton C, Davies D, Balkwill F and Burke F (2005). Involvement of both intrinsic and extrinsic pathways in IFN-gamma-induced apoptosis that are enhanced with cisplatin. Eur J Cancer vol. 41, (10) 1474-1486. 10.1016/j.ejca.2005.03.022Balkwill F (2005). The language of life: How cells communicate in health and disease. Nature vol. 435, (7046) 1162-1162. 10.1038/4351162aBalkwill F (2005). Immunology for the next generation. Nat Rev Immunol vol. 5, (6) 509-512. 10.1038/nri1628Balkwill F and Watt F (2005). Fran Balkwill. J Cell Sci vol. 118, (Pt 7) 1339-1340. 10.1242/jcs.01688Balkwill F, Charles KA and Mantovani A (2005). Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell vol. 7, (3) 211-217. 10.1016/j.ccr.2005.02.0132004
Madhusudan S, Foster M, Muthuramalingam SR, Braybrooke JP, Wilner S, Kaur K, Han C, Hoare S, Balkwill F, Talbot DC, Ganesan TS and Harris AL (2004). A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer. Clin Cancer Res vol. 10, (19) 6528-6534. 10.1158/1078-0432.CCR-04-0730Balkwill F and Coussens LM (2004). Cancer - An inflammatory link. Nature vol. 431, (7007) 405-406. 10.1038/431405aScott KA, Arnott CH, Robinson SC, Moore RJ, Thompson RG, Marshall JF and Balkwill FR (2004). TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration? Oncogene vol. 23, (41) 6954-6966. 10.1038/sj.onc.1207915Hagemann T, Robinson SC, Schulz M, Trümper L, Balkwill FR and Binder C (2004). Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis vol. 25, (8) 1543-1549. 10.1093/carcin/bgh146Jones PH, Christodoulos K, Dobbs N, Thavasu P, Balkwill F, Blann AD, Caine GJ, Kumar S, Kakkar AJ, Gompertz N, Talbot DC, Ganesan TS and Harris AL (2004). Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer. Br J Cancer vol. 91, (1) 30-36. 10.1038/sj.bjc.6601897Balkwill F (2004). Cancer and the chemokine network. Nat Rev Cancer vol. 4, (7) 540-550. 10.1038/nrc1388Li NF, Wilbanks G, Balkwill F, Jacobs IJ, Dafou D and Gayther SA (2004). A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro. Lab Invest vol. 84, (7) 923-931. 10.1038/labinvest.3700093Balkwill F (2004). The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol vol. 14, (3) 171-179. 10.1016/j.semcancer.2003.10.003Grimshaw MJ, Hagemann T, Ayhan A, Gillett CE, Binder C and Balkwill FR (2004). A role for endothelin-2 and its receptors in breast tumor cell invasion. Cancer Res vol. 64, (7) 2461-2468. 10.1158/0008-5472.can-03-1069Arnott CH, Scott KA, Moore RJ, Robinson SC, Thompson RG and Balkwill FR (2004). Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development. Oncogene vol. 23, (10) 1902-1910. 10.1038/sj.onc.1207317Balkwill F, Bast RC, Berek J, Chenevix-Trench G, Gore M, Hamilton T, Jacobs I, Mills G, Souhami R, Urban N, Orsulic S and Smyth J (2004). Current research and treatment for epithelial ovarian cancer. A position paper from the Helene Harris Memorial Trust (vol 39, pg 1818, 2003). Eur J Cancer vol. 40, (4) 628-628. 10.1016/j.ejca.2003.11.005Kulbe H, Levinson NR, Balkwill F and Wilson JL (2004). The chemokine network in cancer - much more than directing cell movement. Int J Dev Biol vol. 48, (5-6) 489-496. 10.1387/ijdb.041814hkSzlosarek P and Balkwill F (2004). The inflammatory cytokine network of epithelial cancer: therapeutic implications. Novartis Found Symp vol. 256, 227-237. 10.1002/0470856734.ch172003
Robinson SC, Scott KA, Wilson JL, Thompson RG, Proudfoot AEI and Balkwill FR (2003). A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res vol. 63, (23) 8360-8365. Madhusudan S, Protheroe A, Propper D, Han C, Corrie P, Earl H, Hancock B, Vasey P, Turner A, Balkwill F, Hoare S and Harris AL (2003). A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer. Brit J Cancer vol. 89, (8) 1418-1422. 10.1038/sj.bjc.6601321Szlosarek PW and Balkwill FR (2003). Tumour necrosis factor alpha: a potential target for the therapy of solid tumours. Lancet Oncol vol. 4, (9) 565-573. 10.1016/s1470-2045(03)01196-3Balkwill F, Bast RC, Berek J, Chenevix-Trench G, Gore M, Hamilton T, Jacobs I, Mills G, Souhami R, Urban N, Orsulic S and Smyth J (2003). Current research and treatment for epithelial ovarian cancer. A Position Paper from the Helene Harris Memorial Trust. Eur J Cancer vol. 39, (13) 1818-1827. 10.1016/s0959-8049(03)00511-2Wall L, Burke F, Barton C, Smyth J and Balkwill F (2003). IFN-gamma induces apoptosis in ovarian cancer cells in vivo and in vitro. Clin Cancer Res vol. 9, (7) 2487-2496. Wall L, Burke F, Barton C, Smyth J and Balkwill F (2003). IFN-γ induces apoptosis in ovarian cancer cells in vivo and in vitro. Clinical Cancer Research vol. 9, (7) 2487-2496. Scott KA, Moore RJ, Arnott CH, East N, Thompson RG, Scallon BJ, Shealy DJ and Balkwill FR (2003). An anti-tumor necrosis factor-alpha antibody inhibits the development of experimental skin tumors. Mol Cancer Ther vol. 2, (5) 445-451. Karagiannis SN, Wang Q, East N, Burke F, Riffard S, Bracher MG, Thompson RG, Durham SR, Schwartz LB, Balkwill FR and Gould HJ (2003). Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells. Eur J Immunol vol. 33, (4) 1030-1040. 10.1002/eji.200323185Balkwill F (2003). Chemokine biology in cancer. Semin Immunol vol. 15, (1) 49-55. 10.1016/s1044-5323(02)00127-6Wall L, Burke F, Smyth JF and Balkwill F (2003). The anti-proliferative activity of interferon-gamma on ovarian cancer: in vitro and in vivo. Gynecologic Oncology vol. 88, (1 Pt 2) 10.1006/gyno.2002.6707Propper DJ, Chao D, Braybrooke JP, Bahl P, Thavasu P, Balkwill F, Turley H, Dobbs N, Gatter K, Talbot DC, Harris AL and Ganesan TS (2003). Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma. Clin Cancer Res vol. 9, (1) 84-92. 2002
Grimshaw MJ, Naylor S and Balkwill FR (2002). Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells. Mol Cancer Ther vol. 1, (14) 1273-1281. Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G and Balkwill FR (2002). Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res vol. 62, (20) 5930-5938. Grimshaw MJ, Wilson JL and Balkwill FR (2002). Endothelin-2 is a macrophage chemoattractant: Implications for macrophage distribution in tumors. European Journal of Immunology vol. 32, (9) 2393-2400. 10.1002/1521-4141(200209)32:9<2393::AID-IMMU2393>3.0.CO;2-4Grimshaw MJ, Wilson JL and Balkwill FR (2002). Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol vol. 32, (9) 2393-2400. 10.1002/1521-4141(200209)32:9<2393::AID-IMMU2393>3.0.CO;2-4Arnott CH, Scott KA, Moore RJ, Hewer A, Phillips DH, Parker P, Balkwill FR and Owens DM (2002). Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway. Oncogene vol. 21, (31) 4728-4738. 10.1038/sj.onc.1205588Balkwill F (2002). Cytokines and infections: good, bad and effective therapies? Elsevier Trends in Immunology vol. 23, (7) 10.1016/s1471-4906(02)02231-7Forster MD, Braybrooke J, Madhusudan S, Kaur K, Hoare S, Balkwill F, Ganesan TS, Talbot D and Harris AL (2002). A phase II trial using etanercept, a recombinant tumour necrosis factor antagonist, in metastatic breast cancer. Brit J Cancer vol. 86, S38-S38. Wall L, Burke F, Smyth J and Balkwill F (2002). Characterisation of the cell content of malignant ascites in advanced epithelial ovarian cancer and clinico-pathological correlations. Brit J Cancer vol. 86, S45-S46. Milliken D, Scotton C, Raju S, Balkwill F and Wilson J (2002). Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res vol. 8, (4) 1108-1114. Balkwill F (2002). Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev vol. 13, (2) 135-141. 10.1016/s1359-6101(01)00020-xWilson J and Balkwill F (2002). The role of cytokines in the epithelial cancer microenvironment. Semin Cancer Biol vol. 12, (2) 113-120. 10.1006/scbi.2001.0419Robinson SC, Scott KA and Balkwill FR (2002). Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-α. European Journal of Immunology vol. 32, (2) 404-412. 10.1002/1521-4141(200202)32:2<404::AID-IMMU404>3.0.CO;2-XRobinson SC, Scott KA and Balkwill FR (2002). Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-alpha. Eur J Immunol vol. 32, (2) 404-412. 10.1002/1521-4141(200202)32:2<404::AID-IMMU404>3.0.CO;2-X2001
Scotton C, Milliken D, Wilson J, Raju S and Balkwill F (2001). Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br J Cancer vol. 85, (6) 891-897. 10.1054/bjoc.2001.2020Scotton CJ, Wilson JL, Milliken D, Stamp G and Balkwill FR (2001). Epithelial cancer cell migration: a role for chemokine receptors? Cancer Res vol. 61, (13) 4961-4965. Grimsha MJ and Balkwill FR (2001). Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - A potential mechanism. Brit J Cancer vol. 85, 19-19. Grimshaw MJ and Balkwill FR (2001). Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - A potential mechanism. European Journal of Immunology vol. 31, (2) 480-489. 10.1002/1521-4141(200102)31:2<480::AID-IMMU480>3.0.CO;2-LPropper DJ, McDonald AC, Man A, Thavasu P, Balkwill F, Braybrooke JP, Caponigro F, Graf P, Dutreix C, Blackie R, Kaye SB, Ganesan TS, Talbot DC, Harris AL and Twelves C (2001). Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol vol. 19, (5) 1485-1492. 10.1200/JCO.2001.19.5.1485Balkwill F and Mantovani A (2001). Inflammation and cancer: back to Virchow? Lancet vol. 357, (9255) 539-545. 10.1016/S0140-6736(00)04046-0Grimshaw MJ and Balkwill FR (2001). Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - a potential mechanism. Eur J Immunol vol. 31, (2) 480-489. 10.1002/1521-4141(200102)31:2<480::aid-immu480>3.0.co;2-l2000
Jankowski JA, Harrison RF, Perry I, Balkwill F and Tselepis C (2000). Barrett's metaplasia. Lancet vol. 356, (9247) 2079-2085. 10.1016/S0140-6736(00)03411-5Balkwill FR (2000). Re: Possible role of ovarian epithelial inflammation in ovarian cancer. J Natl Cancer Inst vol. 92, (2) 162-163. 10.1093/jnci/92.2.162aSica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F and Mantovani A (2000). Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. Journal of Immunology vol. 164, (2) 733-738. 10.4049/jimmunol.164.2.733Scott KA, Holdsworth H, Balkwill FR and Dias S (2000). Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model. British Journal of Cancer vol. 83, (11) 1538-1543. 10.1054/bjoc.2000.14871999
Thavasu P, Propper D, McDonald A, Dobbs N, Ganesan T, Talbot D, Braybrook J, Caponigro F, Hutchison C, Twelves C, Man A, Fabbro D, Harris A and Balkwill F (1999). The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients. Cancer Research vol. 59, (16) 3980-3984. Turner L, Scotton C, Negus R and Balkwill F (1999). Hypoxia inhibits macrophage migration. European Journal of Immunology vol. 29, (7) 2280-2287. 10.1002/(SICI)1521-4141(199907)29:07<2280::AID-IMMU2280>3.0.CO;2-CTurner L, Scotton C, Negus R and Balkwill F (1999). Hypoxia inhibits macrophage migration. Eur J Immunol vol. 29, (7) 2280-2287. 10.1002/(SICI)1521-4141(199907)29:07<2280::AID-IMMU2280>3.0.CO;2-CMoore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N, Holdsworth H, Turner L, Rollins B, Pasparakis M, Kollias G and Balkwill F (1999). Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis. Nature Medicine vol. 5, (7) 828-831. 10.1038/10552Burke F, Smith PD, Crompton MR, Upton C and Balkwill FR (1999). Cytotoxic response of ovarian cancer cell lines to IFN-γ is associated with sustained induction of IRF-1 and p21 mRNA. British Journal of Cancer vol. 80, (8) 1236-1244. 10.1038/sj.bjc.6690491Boyd RS and Balkwill FR (1999). MMP-2 release and activation in ovarian carcinoma: The role of fibroblasts. British Journal of Cancer vol. 80, (3-4) 315-321. 10.1038/sj.bjc.6690357Balkwill F (1999). TNF biosynthesis in gut associated immunopathologies. Gut vol. 45, (4) 10.1136/gut.45.4.483Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N, Holdsworth H, Turner L, Rollins B, Pasparakis M, Kollias G and Balkwill F (1999). Erratum: Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis (Nature Medicine (1999) 5 (828-831)). Nature Medicine vol. 5, (9) 10.1038/125321998
Dias S, Boyd R and Balkwill F (1998). IL-12 regulates VEGF and MMPs in a murine breast cancer model. Int J Cancer vol. 78, (3) 361-365. 10.1002/(SICI)1097-0215(19981029)78:3<361::AID-IJC17>3.0.CO;2-9Dias S, Boyd R and Balkwill F (1998). IL-12 regulates VEGF and MMPs in a murine breast cancer model. International Journal of Cancer vol. 78, (3) 361-365. 10.1002/(SICI)1097-0215(19981029)78:3<361::AID-IJC17>3.0.CO;2-9Dias S, Thomas H and Balkwill F (1998). Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model. Int J Cancer vol. 75, (1) 151-157. 10.1002/(sici)1097-0215(19980105)75:1<151::aid-ijc23>3.0.co;2-iDias S, Thomas H and Balkwill F (1998). Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model. International Journal of Cancer vol. 75, (1) 151-157. 10.1002/(SICI)1097-0215(19980105)75:1<151::AID-IJC23>3.0.CO;2-INegus RPM, Turner L, Burke F and Balkwill FR (1998). Hypoxia down-regulates MCP-1 expression: Implications for macrophage distribution in tumors. Journal of Leukocyte Biology vol. 63, (6) 758-765. 10.1002/jlb.63.6.758Balkwill F (1998). The molecular and cellular biology of the chemokines. Journal of Viral Hepatitis vol. 5, (1) 1-14. 10.1046/j.1365-2893.1998.00081.xLeber TM and Balkwill FR (1998). Regulation of monocyte MMP-9 production by TNF-α and a tumour-derived soluble factor (MMPSF). British Journal of Cancer vol. 78, (6) 724-732. 10.1038/bjc.1998.568Workman P, Twentyman P, Balkwill F, Balmain A, Chaplin D, Double J, Embleton J, Newell D, Raymond R, Stables J, Stephens T, Wallace J and Navaratnam V (1998). United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). British Journal of Cancer vol. 77, (1) 1-10. 10.1038/bjc.1998.11997
Leber TM and Balkwill FR (1997). Zymography: A single-step staining method for quantitation of proteolytic activity on substrate gels. Analytical Biochemistry vol. 249, (1) 24-28. 10.1006/abio.1997.2170Burke F, East N, Upton C, Patel K and Balkwill FR (1997). Interferon gamma induces cell cycle arrest and apoptosis in a model of ovarian cancer: Enhancement of effect by batimastat. European Journal of Cancer Part A vol. 33, (7) 1114-1121. 10.1016/S0959-8049(97)88065-3Balkwill F (1997). Cytokine amplification and inhibition of immune and inflammatory responses. Journal of Viral Hepatitis vol. 4 Suppl 2, 6-15. 10.1111/j.1365-2893.1997.tb00175.xNegus RPM, Stamp GWH, Hadley J and Balkwill FR (1997). Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. American Journal of Pathology vol. 150, (5) 1723-1734. 1996
Zucker S and Balkwill FR (1996). Correspondence re: N-B. Liabakk et al., Matrix metalloprotease 2 (MMP- 2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res., 56: 190-196, 1996. Cancer Research vol. 56, (15) Burke F and Balkwill FR (1996). Cytokines in animal models of cancer. Biotherapy vol. 8, (3-4) 229-241. 10.1007/BF01877209Balkwill FR (1996). Cytokines in Hemopoiesis, Oncology, and Immunology III. British Journal of Cancer vol. 73, (5) 711-711. 10.1038/bjc.1996.124Burke F, Relf M, Negus R and Balkwill F (1996). A cytokine profile of normal and malignant ovary. Cytokine vol. 8, (7) 578-585. 10.1006/cyto.1996.0077Liabakk NB, Talbot I, Smith RA, Wilkinson K and Balkwill F (1996). Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Research vol. 56, (1) 190-196. Negus RPM and Balkwill FR (1996). Cytokines in tumour growth, migration and metastasis. World Journal of Urology vol. 14, (3) 157-165. 10.1007/BF00186895Thomas H, Hanby AM, Smith RA, Hagger P, Patel K, Raikundalia B, Camplejohn RS and Balkwill FR (1996). An inbred colony of oncogene transgenic mice: Diversity of tumours and potential as a therapeutic model. British Journal of Cancer vol. 73, (1) 65-72. 10.1038/bjc.1996.121995
Thomas H and Balkwill F (1995). Assessing new anti-tumour agents and strategies in oncogene transgenic mice. Cancer and Metastasis Reviews vol. 14, (2) 91-95. 10.1007/BF00665793de Kossodo S, Moore R, Gschmeissner S, East N and Balkwill FR (1995). Changes in endogenous cytokines, adhesion molecules and platelets during cytokine-induced tumour necrosis. British Journal of Cancer vol. 72, (5) 1165-1172. 10.1038/bjc.1995.481Negus RPM, Stamp GWH, Relf MG, Burke F, Malik STA, Bernasconi S, Allavena P, Sozzani S, Mantovani A and Balkwill FR (1995). The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. Journal of Clinical Investigation vol. 95, (5) 2391-2396. 10.1172/JCI117933Thavasu PW, Ganjoo RK, Maidment SA, Love SB, Williams AH, Malplas JS and Balkwill FR (1995). Multiple myeloma: An immunoclinical study of disease and response to treatment. Hematological Oncology vol. 13, (2) 69-82. 10.1002/hon.2900130204Burke F, Knowles RG, East N and Balkwill FR (1995). THE role of indoleamine 2,3‐dioxygenase in the anti‐tumour activity of human interferon‐γ in vivo. International Journal of Cancer vol. 60, (1) 115-122. 10.1002/ijc.2910600117Balkwill F (1995). Tumour necrosis factor in ovarian cancer. Interferons and Cytokines (26) 6-8. Burger D, Dayer JM, Opdenakker G, Van Damme J, Mauviel A, Proost P, Gijbels K, Masure S, Carton H, Brennan FM, Feldmann M, Lacraz S, Miltenburg AMM, Welgus HG, Isler P, Vey E, Zhang JH, Ferrante A and Arrigo AP (1995). Inhibitory cytokines and cytokine inhibitors. Neurology vol. 45, (6) S39-S43. 10.1212/wnl.45.6_suppl_6.s391994
Miles DW, Happerfield LC, Naylor MS, Bobrow LG, Rubens RD and Balkwill FR (1994). Expression of tumour necrosis factor (TNF alpha) and its receptors in benign and malignant breast tissue. Int J Cancer vol. 56, (6) 777-782. 10.1002/ijc.2910560603Balkwill FR (1994). Cytokine therapy of cancer. The importance of knowing the context. European Cytokine Network vol. 5, (4) 379-385. Naylor MS, Stamp GW, Davies BD and Balkwill FR (1994). Expression and activity of MMPS and their regulators in ovarian cancer. International Journal of Cancer vol. 58, (1) 50-56. 10.1002/ijc.2910580110Thomas H and Balkwill FR (1994). Oncogene transgenic mice as therapeutic models in cancer research. European Journal of Cancer vol. 30, (4) 533-537. 10.1016/0959-8049(94)90434-0MILES D, THOMSEN L, BALKWILL F, THAVASU P and MONCADA S (1994). Association between biosynthesis of nitric oxide and changes in immunological and vascular parameters in patients treated with interleukin‐2. European Journal of Clinical Investigation vol. 24, (4) 287-290. 10.1111/j.1365-2362.1994.tb01087.x1993
Philip PA, Rea D, Thavasu P, Carmichael J, Stuart NSA, Rockett H, Talbot DC, Ganesan T, Pettit GR, Balkwill F and Harris AL (1993). Phase I study of bryostatin 1: Assessment of interleukin 6 and tumor necrosis factor α induction in vivo. Journal of The National Cancer Institute vol. 85, (22) 1812-1818. 10.1093/jnci/85.22.1812Davies B, Waxman J, Wasan H, Abel P, Williams G, Krausz T, Neal D, Thomas D, Hanby A and Balkwill F (1993). Levels of Matrix Metalloproteases in Bladder Cancer Correlate with Tumor Grade and Invasion. Cancer Research vol. 53, (22) 5365-5369. Burke F, Stuart Naylor M, Davies B and Balkwill F (1993). The cytokine wall chart. Trends in Immunology vol. 14, (4) 10.1016/0167-5699(93)90280-xBalkwill F (1993). Tumour necrosis factor. Improving on the formula. Nature vol. 361, (6409) 206-207. 10.1038/361206a0Davies B, Miles DW, Happerfield LC, Naylor MS, Bobrow LG, Rubens RD and Balkwill FR (1993). Activity of type IV collagenases in benign and malignant breast disease. British Journal of Cancer vol. 67, (5) 1126-1131. 10.1038/bjc.1993.207Taylor-Papadimitriou J and Balkwill F (1993). Fusion potential for vaccines. Nature vol. 362, (6422) 10.1038/362695a0Saraya KA and Balkwill FR (1993). Temporal sequence and cellular origin of interleukin-2 stimulated cytokine gene expression. British Journal of Cancer vol. 67, (3) 514-521. 10.1038/bjc.1993.96Davies B, Brown PD, East N, Crimmin MJ and Balkwill FR (1993). A Synthetic Matrix Metalloproteinase Inhibitor Decreases Tumor Burden and Prolongs Survival of Mice Bearing Human Ovarian Carcinoma Xenograft. Cancer Research vol. 53, (9) 2087-2091. Naylor MS, Stamp GWH, Foulkes WD, Eccles D and Balkwill FR (1993). Tumor necrosis factor and its receptors in human ovarian cancer: Potential role in disease progression. Journal of Clinical Investigation vol. 91, (5) 2194-2206. 10.1172/JCI116446Burke F, Stuart Naylor M, Davies B and Balkwill F (1993). The cytokine wall chart. Immunology Today vol. 14, (4) 10.1016/0167-5699(93)90280-XBurke F, Griffin D, Elwood N, Davis C, Stamp G, Rohatiner A, Lister TA and Balkwill F (1993). The effect of cytokines on cultured mononuclear cells from patients with B cell chronic lymphocytic leukemia. Hematological Oncology vol. 11, (1) 23-33. 10.1002/hon.29001101041992
Thavasu PW, Longhurst S, Joel SP, Slevin ML and Balkwill FR (1992). Measuring cytokine levels in blood. Importance of anticoagulants, processing, and storage conditions. Journal of Immunological Methods vol. 153, (1-2) 115-124. 10.1016/0022-1759(92)90313-IMiles DW, Aderka D, Engelmann H, Wallach D and Balkwill FR (1992). Induction of soluble tumour necrosis factor receptors during treatment with interleukin-2. British Journal of Cancer vol. 66, (6) 1195-1199. 10.1038/bjc.1992.435Naylor MS, Stamp GW and Balkwill FR (1992). Beta actin expression and organization of actin filaments in colorectal neoplasia. Epithelial Cell Biology vol. 1, (3) 99-104. Balkwill FR (1992). Tumour necrosis factor and cancer. Progress in Growth Factor Research vol. 4, (2) 121-137. 10.1016/0955-2235(92)90027-FMalik ST and Balkwill FR (1992). Antiproliferative and antitumor activity of TNF in vitro and in vivo. Immunology Series vol. 56, 239-268. Malik TAS, East N, Boraschi D and Balkwill FR (1992). Effects of intraperitoneal recombinant interleukin-1β in intraperitoneal human ovarian cancer xenograft models: Comparison with the effects of tumour necrosis factor. British Journal of Cancer vol. 65, (5) 661-666. 10.1038/bjc.1992.1411991
Miles DW, Longhurst SJ, Harper PG and Balkwill FR (1991). Toxicity and reconstitution of recombinant interleukin-2 with albumin. The Lancet vol. 338, (8780) 10.1016/0140-6736(91)92770-3Kelly SA, Gschmeissner S, East N and Balkwill FR (1991). Enhancement of Metastatic Potential by γ-Interferon. Cancer Research vol. 51, (15) 4020-4027. Stanley LA, Adams DJ, Balkwill FR, Griffin D and Roland Wolf C (1991). Differential effects of recombinant interferon α on constitutive and inducible cytochrome P450 isozymes in mouse liver. Biochemical Pharmacology vol. 42, (2) 311-320. 10.1016/0006-2952(91)90718-KThomas H and Balkwill FR (1991). Effects of interferons and other cytokines on tumors in animals: A review. Pharmacology and Therapeutics vol. 52, (3) 307-330. 10.1016/0163-7258(91)90030-PMalik STA, Knowles RG, East N, Lando D, Stamp G and Balkwill FR (1991). Antitumor Activity of -y-Interferon in Ascitic and Solid Tumor Models of Human Ovarian Cancer. Cancer Research vol. 51, (24) 6643-6649. Malik S and Balkwill F (1991). Epithelial ovarian cancer: A cytokine propelled disease? British Journal of Cancer vol. 64, (4) 617-620. 10.1038/bjc.1991.372Lagadec PF, Saraya KA and Balkwill FR (1991). Human small‐cell lung‐cancer cells are cytokine‐resistant but NK/LAK‐sensitive. International Journal of Cancer vol. 48, (2) 311-317. 10.1002/ijc.2910480226Malik STA, Martin D, Hart I and Balkwill F (1991). Therapy of human ovarian cancer xenografts with intraperitoneal liposome encapsulated muramyl-tripeptide phosphoethanolamine (MTP-PE) and recombinant GM-CSF. British Journal of Cancer vol. 63, (3) 399-403. 10.1038/bjc.1991.921990
Naylor MS, Stamp GWH and Balkwill FR (1990). Investigation of Cytokine Gene Expression in Human Colorectal Cancer. Cancer Research vol. 50, (14) 4436-4440. Miles DW, Bird CR, Wadhwa M, Summerhayes M, Balkwill FR, Thorpe R and Rubens RD (1990). Reconstitution of interleukin 2 with albumin for infusion. The Lancet vol. 335, (8705) 1602-1603. 10.1016/0140-6736(90)91439-HStuart Naylor M, Malik STA, Stamp GWH, Jobling T and Balkwill FR (1990). In situ detection of tumour necrosis factor in human ovarian cancer specimens. European Journal of Cancer and Clinical Oncology vol. 26, (10) 1027-1030. 10.1016/0277-5379(90)90043-SMalik STA, Stuart Naylor M, East N, Oliff A and Balkwill FR (1990). Cells secreting tumour necrosis factor show enhanced metastasis in nude mice. European Journal of Cancer and Clinical Oncology vol. 26, (10) 1031-1034. 10.1016/0277-5379(90)90044-TBalkwill FR, Stuart Naylor M and Malik S (1990). Tumour necrosis factor as an anticancer agent. European Journal of Cancer and Clinical Oncology vol. 26, (5) 641-644. 10.1016/0277-5379(90)90097-DMalik ST, Griffin DB, Naylor MS, Fiers W, Oliff A and Balkwill FR (1990). The complex effects of recombinant tumour necrosis factor-alpha (rhTNF-alpha) in human ovarian cancer xenograft models. Progress in Clinical and Biological Research vol. 349, 393-403. 1989
Fiers W and Balkwill FR (1989). Future prospects and problems. Cancer Surveys vol. 8, (4) 921-927. Kelly SA, Malik STA and Balkwill FR (1989). The relevance of animal tumour models to the preclinical screening of cytokines. Cancer Surveys vol. 8, (4) 741-754. Stebbings WSL, Vinson GP, Farthing MJG, Balkwill F and Wood RFM (1989). Effect of steroid hormones on human colorectal adenocarcinoma xenografts, of known steroid-receptor status, in nude mice. Journal of Cancer Research and Clinical Oncology vol. 115, (5) 439-444. 10.1007/BF00393333Balkwill FR (1989). INTERFERONS. The Lancet vol. 333, (8646) 1060-1063. 10.1016/S0140-6736(89)92455-0Malik STA, Griffin DB, Fiers W and Balkwill FR (1989). Paradoxical effects of tumour necrosis factor in experimental ovarian cancer. International Journal of Cancer vol. 44, (5) 918-925. 10.1002/ijc.2910440529Balkwill FR, Griffin DB and Lee AE (1989). Interferons alpha and gamma differ in their ability to cause tumour stasis and regression in vivo. European Journal of Cancer and Clinical Oncology vol. 25, (10) 1481-1486. 10.1016/0277-5379(89)90108-9Balkwill FR and Burke F (1989). The cytokine network. Immunology Today vol. 10, (9) 299-304. 10.1016/0167-5699(89)90085-6Balkwill FR (1989). Tumour necrosis factor. British Medical Bulletin vol. 45, (2) 389-400. 10.1093/oxfordjournals.bmb.a072330Ramani P and Balkwill FR (1989). Action of recombinant alpha interferon against experimental and spontaneous metastases in a murine model. International Journal of Cancer vol. 43, (1) 140-146. 10.1002/ijc.29104301261988
Balkwill F (1988). Cytokines - soluble factors in immune responses. Current Opinion in Immunology vol. 1, (2) 241-249. 10.1016/0952-7915(88)90008-8Ramani P and Balkwill FR (1988). Human interferons inhibit experimental metastases of a human melanoma cell line in nude mice. British Journal of Cancer vol. 58, (3) 350-354. 10.1038/bjc.1988.217Fentiman IS, Balkwill FR, Thomas BS, Russell MJ, Todd I and Bottazzo GF (1988). An autoimmune aetiology for hypothyroidism following interferon therapy for breast cancer. European Journal of Cancer and Clinical Oncology vol. 24, (8) 1299-1303. 10.1016/0277-5379(88)90219-2Malik S and Balkwill F (1988). The anti-cancer activity of tumour necrosis factor. Annales De L'Institut Pasteur. Immunology vol. 139, (3) 285-288. Malik S and Balkwill FR (1988). Tumour necrosis factor. British Medical Journal (Clinical Research Ed.) vol. 296, (6631) 10.1136/bmj.296.6631.12141987
Fentiman IS, Balkwill FR, Cuzick J, Hayward JL and Rubens RD (1987). A trial of human alpha interferon as an adjuvant agent in breast cancer after loco-regional recurrence. European Journal of Surgical Oncology vol. 13, (5) 425-428. Balkwill F, Burke F, Talbot D, Tavernier J, Osborne R, Naylor S, Durbin H and Fiers W (1987). EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER. The Lancet vol. 330, (8570) 1229-1232. 10.1016/S0140-6736(87)91850-2Adams DJ, Balkwill FR, Griffin DB, Hayes JD, Lewis AD and Wolf CR (1987). Induction and suppression of glutathione transferases by interferon in the mouse. Journal of Biological Chemistry vol. 262, (10) 4888-4892. 10.1016/s0021-9258(18)61279-7Balkwill FR and Smyth JF (1987). INTERFERONS IN CANCER THERAPY: A REAPPRAISAL. The Lancet vol. 330, (8554) 317-319. 10.1016/S0140-6736(87)90901-9Ward BG and Balkwill FR (1987). Intraperitoneal Xenografts of Human Epithelial Ovarian Cancer in Nude Mice. Cancer Research vol. 47, (10) 2662-2667. Ramani P and Balkwill FR (1987). Enhanced metastases of a mouse carcinoma after in vitro treatment with murine interferon gamma. International Journal of Cancer vol. 40, (6) 830-834. 10.1002/ijc.2910400621Tilles JG, Balkwill F and Davilla J (1987). 2′,5′-Oligoadenylate Synthetase and Interferon in Peripheral Blood after Rubella, Measles, or Mumps Live Virus Vaccine. Proceedings of The Society For Experimental Biology and Medicine vol. 186, (1) 70-74. 10.3181/00379727-186-42586Balkwill FR, Ward IBG, Moodie E and Fiers W (1987). Therapeutic Potential of Tumor Necrosis Factor-α and γ-Interferon in Experimental Human Ovarian Cancer. Cancer Research vol. 47, (18) 4755-4758. Smyth JF, Balkwill FR, Cavalli F, Kimchi A, Mattson K, Niederle NE and Spiegel RJ (1987). Interferons in oncology: Current status and future directions. European Journal of Cancer and Clinical Oncology vol. 23, (6) 887-889. 10.1016/0277-5379(87)90298-7Dealtry GB, Naylor MS, Fiers W and Balkwill FR (1987). The effect of recombinant human tumour necrosis factor on growth and macromolecular synthesis of human epithelial cells. Experimental Cell Research vol. 170, (2) 428-438. 10.1016/0014-4827(87)90318-1Dealtry GB, Naylor MS, Fiers W and Balkwill FR (1987). DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ. European Journal of Immunology vol. 17, (5) 689-693. 10.1002/eji.1830170517Balkwill FR, Ward BG and Fiers W (1987). Effects of tumour necrosis factor on human tumour xenografts in nude mice. Ciba Foundation Symposium vol. 131, 154-169. 10.1002/9780470513521.ch11Balkwill FR, Stevens MH, Griffin DB, Thomas JA and Bodmer JG (1987). Interferon gamma regulates HLA-D expression on solid tumors in vivo. European Journal of Cancer and Clinical Oncology vol. 23, (1) 10.1016/0277-5379(87)90426-31986
Rowlinson G, Balkwill F, Snook D, Hooker G and Epenetos AA (1986). Enhancement by gamma-interferon of in vivo tumor radiolocalization by a monoclonal antibody against HLA-DR antigen. Cancer Res vol. 46, (12 Pt 1) 6413-6417. Balkwill FR (1986). Interferons: From molecular biology to man. Part 3. Interferons and disease. Microbiological Sciences vol. 3, (9) 281-284. Balkwill FR (1986). Interferons: From molecular biology to man. Part 2. Interferons and cell function. Microbiological Sciences vol. 3, (8) 229-233. Balkwill FR (1986). Interferons: From molecular biology to man. Part 1. Genetics and molecular biology of the interferon system. Microbiological Sciences vol. 3, (7) 212-215. Carmichael J, Fergusson RJ, Wolf CR, Balkwill FR and Smyth JF (1986). Augmentation of cytotoxicity of Chemotherapy by Human ɑ-Interferons in Human Non–Small Cell Lung Cancer Xenografts. Cancer Research vol. 46, (10) 4916-4920. Balkwill FR and Proietti E (1986). Effects of mouse interferon on human tumour xenografts in the nude mouse host. International Journal of Cancer vol. 38, (3) 375-380. 10.1002/ijc.2910380312Balkwill FR, Lee A, Aldam G, Moodie E, Thomas JA, Tavernier J and Fiers W (1986). Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons. Cancer Research vol. 46, (8) 3990-3993. Ramani P, Hart IR and Balkwill FR (1986). The effect of interferon on experimental metastases in immunocompetent and immunodeficient mice. International Journal of Cancer vol. 37, (4) 563-568. 10.1002/ijc.2910370415Balkwill FR (1986). Animal Models for Investigating Antitumor Effects of Interferon. Methods in Enzymology vol. 119, (C) 649-657. 10.1016/0076-6879(86)19087-21985
Rohatiner AZ, Prior P, Burton A, Balkwill F and Lister TA (1985). Central nervous system toxicity of interferon. Progress in Experimental Tumor Research. Fortschritte Der Experimentellen Tumorforschung. Progres De La Recherche Experimentale vol. 29, 197-202. 10.1159/000411640Fentiman IS, Thomas BS, Balkwill FR, Rubens RD and Hayward JL (1985). PRIMARY HYPOTHYROIDISM ASSOCIATED WITH INTERFERON THERAPY OF BREAST CANCER. The Lancet vol. 325, (8438) 10.1016/S0140-6736(85)92475-4Taylor-Papadimitriou J, Balkwill F, Ebsworth N and Rozengurt E (1985). Antiviral and antiproliferative effects of interferons in quiescent fibroblasts are dissociable. Virology vol. 147, (2) 405-412. 10.1016/0042-6822(85)90142-4Balkwill FR, Goldstein L and Stebbing N (1985). Differential action of six human interferons against two human carcinomas growing in nude mice. International Journal of Cancer vol. 35, (5) 613-617. 10.1002/ijc.2910350508Bye A, Balkwill F, Brigden D and Wilson J (1985). USE OF INTERFERON IN THE MANAGEMENT OF PATIENTS WITH SUBACUTE SCLEROSING PANENCEPHALITIS. Developmental Medicine &Amp; Child Neurology vol. 27, (2) 170-175. 10.1111/j.1469-8749.1985.tb03766.xPadmanabhan N, Balkwill FR, Bodmer JG and Rubens RD (1985). Recombinant DNA human interferon alpha 2 in advanced breast cancer: A phase 2 trial. British Journal of Cancer vol. 51, (1) 55-60. 10.1038/bjc.1985.81984
Shearer M, Taylor-Papadimitriou J, Griffin D and Balkwill F (1984). Monoclonal antibodies that distinguish between subspecies of human interferon-α and that detect interferon oligomers. Journal of Immunology vol. 133, (6) 3096-3101. 10.4049/jimmunol.133.6.3096Balkwill FR, Moodie EM, Griffin DB, Seilman SS, Wolf CR, Mowshowitz S and Fantes KH (1984). Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drug-metabolizing enzymes. Cancer Research vol. 44, (11) 5249-5255. Balkwill FR and Moodie EM (1984). Positive interactions between human interferon and cyclophosphamide or adriamycin in a human tumor model system. Cancer Research vol. 44, (3) 904-908. Borden EC and Balkwill FR (1984). Preclinical and clinical studies of interferons and interferon inducers in breast cancer. Cancer vol. 53, (3 Suppl) 783-789. 10.1002/1097-0142(19840201)53:3+<783::aid-cncr2820531329>3.0.co;2-iBalkwill FR and Bokhon'ko AI (1984). Differential effects of pure human alpha and gamma interferons on fibroblast cell growth and the cell cycle. Experimental Cell Research vol. 155, (1) 190-197. 10.1016/0014-4827(84)90780-8Borden EC and Balkwill FR (1984). Preclinical and clinical studies of interferons and interferon inducers in breast cancer. Cancer vol. 53, (3 S) 783-789. 10.1002/1097-0142(19840201)53:3+<783::AID-CNCR2820531329>3.0.CO;2-I1983
Balkwill FR, Griffin DB, Band HA and Beverley PCL (1983). Immune human lymphocytes produce an acid-labile α-interferon. Journal of Experimental Medicine vol. 157, (3) 1059-1063. 10.1084/jem.157.3.1059Rohatiner AZS, Prior PF, Burton AC, Smith AT, Balkwill FR and Lister TA (1983). Central nervous system toxicity of interferon. British Journal of Cancer vol. 47, (3) 419-422. 10.1038/bjc.1983.63Rohatiner AZS, Balkwill FR, Malpas JS and Lister TA (1983). Experience with human lymphoblastoid interferon in acute myelogenous leukaemia (AML). Cancer Chemotherapy and Pharmacology vol. 11, (1) 56-58. 10.1007/BF00257419Rohatiner AZ, Balkwill F and Lister TA (1983). Interferon in acute myelogenous leukaemia: a preliminary report. Haematology and Blood Transfusion vol. 28, 56-58. 10.1007/978-3-642-68761-7_11McCance DJ, Sebesteny A, Griffin BE, Balkwill F, Tilly R and Gregson NA (1983). A paralytic disease in nude mice associated with polyoma virus infection. Journal of General Virology vol. 64, (1) 57-67. 10.1099/0022-1317-64-1-57Balkwill FR, Moodie EM, Freedman V, Lane EB and Fantes KH (1983). An Animal Model System for Investigating the AntiTumor Effects of Human Interferon. Journal of Interferon Research vol. 3, (3) 319-326. 10.1089/jir.1983.3.3191982
Taylor-Papadimitriou J and Balkwill FR (1982). Implications for clinical application of new developments in interferon research. Bba - Reviews On Cancer vol. 695, (1) 49-67. 10.1016/0304-419X(82)90006-3Balkwill FR, Moodie EM, Freedman V and Fantes KH (1982). Human interferon inhibits the growth of established human breast tumours in the nude mouse. International Journal of Cancer vol. 30, (2) 231-235. 10.1002/ijc.2910300217SILVERMAN RH, WATLING D, BALKWILL FR, TROWSDALE J and KERR IM (1982). The ppp(A2′p)Taylor-Papadimitriou J, Shearer M, Balkwill FR and Fantes KH (1982). Effects of HuIFN-α2 and HuIFN-α (Namalwa) on Breast Cancer Cells Grown in Culture and as Xenografts in the Nude Mouse. Journal of Interferon Research vol. 2, (4) 479-491. 10.1089/jir.1982.2.479Rohatiner AZS, Balkwill FR, Griffin DB, Malpas JS and Lister TA (1982). A phase I study of human lymphoblastoid interferon administered by continuous intravenous infusion. Cancer Chemotherapy and Pharmacology vol. 9, (2) 97-102. 10.1007/BF002653871981
Balkwill FH (1981). Extracts from the last century. Mechanical dentistry--on regulation cases by F.H. Balkwill. British Dental Journal vol. 151, (1) 10.1038/sj.bdj.4804620Rohatiner A, Balkwill F, Malpas JS and Lister TA (1981). A phase I study of human lymphoblastoid interferon in patients with hematological malignancies. Haematology and Blood Transfusion vol. 26, 63-67. 10.1007/978-3-642-67984-1_9Hogg N and Balkwill FR (1981). Species restriction in cytostatic activity of human and murine monocytes and macrophages. Immunology vol. 43, (1) 197-204. Rohatiner AZS, Balkwill F, Malpas JS and Lister TA (1981). A phase I study of intravenous human lymphoblastoid interferon (HLBI). Proceedings of The American Association For Cancer Research vol. Vol. 22, 1980
Sebesteny A, Tilly R, Balkwill F and Trevan D (1980). Demyelination and wasting associated with polyomavirus infection in nude (nu/nu) mice. Laboratory Animals vol. 14, (4) 337-345. 10.1258/002367780781071021Balkwill F, Taylor-Papadimitriou J, Fantes KH and Sebesteny A (1980). Human lymphoblastoid interferon can inhibit the growth of human breast cancer xenografts in athymic (nude) mice. European Journal of Cancer (1965) vol. 16, (4) 569-573. 10.1016/0014-2964(80)90237-6Balkwill F, Taylor‐Papadimitriou J, Fantes KH and Sebesteny A (1980). HUMAN LYMPHOBLASTOID INTERFERON CAN INHIBIT THE GROWTH OF HUMAN BREAST CANCER XENOGRAFTS IN ATHYMIC [NUDE] MICE. Annals of The New York Academy of Sciences vol. 350, (1) 591-592. 10.1111/j.1749-6632.1980.tb20671.x1979
Balkwill FR and Hogg N (1979). Characterization of human breast milk macrophages cytostatic for human cell lines. Journal of Immunology vol. 123, (4) 1451-1456. 10.4049/jimmunol.123.4.1451Balkwill FR and Oliver RTD (1979). REMISSION IN ACUTE MYELOBLASTIC LEUKÆMIA. The Lancet vol. 314, (8149) 961-962. 10.1016/S0140-6736(79)92658-8Balkwill FR (1979). Interferons as cell-regulatory molecules. Cancer Immunology Immunotherapy vol. 7, (1) 7-14. 10.1007/BF002054031978
Balkwill F and Taylor-Papadimitriou J (1978). Interferon affects both GBalkwill F, Watling D and Taylor‐Papadimitriou J (1978). Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast. International Journal of Cancer vol. 22, (3) 258-265. 10.1002/ijc.29102203071977
Balkwill FR and Oliver RTD (1977). Growth inhibitory effects of interferon on normal and malignant human haemopoietic cells. International Journal of Cancer vol. 20, (4) 500-505. 10.1002/ijc.2910200405Balkwill FR, Franks CR, Oliver RTD and Spector WG (1977). Neoplastic macrophages grown from human leukaemic monocytes. The Journal of Pathology vol. 122, (1) 13-26. 10.1002/path.1711220104Franks CR, Bishop D, Balkwill FR, Oliver RTD and Spector WG (1977). Growth of acute myeloid leukaemia as discrete subcutaneous tumours in immune-deprived mice. British Journal of Cancer vol. 35, (5) 697-700. 10.1038/bjc.1977.1071976
Balkwill FR and Oliver RT (1976). Diagnostic and prognostic significance of peripheral blood cultural characteristics in adult acute leukaemia. British Journal of Cancer vol. 33, (4) 400-410. 10.1038/bjc.1976.65Balkwill FR and Oliver RTD (1976). Morphological characterisation of adult acute leukaemia in short term liquid culture. Recent Results in Cancer Research vol. No.56, 87-90. 10.1007/978-3-642-81049-7_121974
Balkwill F, Pindar A and Crowther D (1974). Factors influencing microculture of leukaemia cells. Nature vol. 251, (5477) 741-742. 10.1038/251741a0Grants
Grants of specific relevance to Predictive in vitro Models
Role of JAM-C in inflammatory and vascular events in vivo as studied using an experimental model of ovarian cancer.Nourshargh S and Balkwill FR
£227,807 Wellcome Trust (01-01-2010 - 31-12-2012)