Dr Adrian Biddle
DHT Lecturer in Animal Replacement Science
CPM Annual Symposium Organiser
Centre for Cell Biology & Cutaneous Research, Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
cancer stem cells, tumour metastasis, 3D tumour invasion, metastasis on a chip, organ-on-a-chip, machine learning
Interests
Cancer stem cells drive tumour metastasis and therapeutic resistance. Understanding the underlying mechanisms will be crucial if we are to deliver better treatments for cancer, and we model this process using human cancer cell lines in advanced 3D invasion and microfluidic metastasis systems.We also use human tissue archives, which provide a wealth of information on tumour behaviour in the human body, including data on the clinical course of disease. We have developed new ways of obtaining greater information from these tumour specimens, including simultaneous measurement of multiple cancer stem cell markers and a machine learning approach for prognostic prediction.
Publications
2025

Stabile R, Tucci FA, Verhagen MP, Embregts C, van den Bosch TPP, Joosten R, De Herdt MJ, van der Steen B et al.
Journal of The National Cancer Institute, Oxford University Press (Oup)
18-03-2025
2024

Scemama A, Lunetto S, Tailor A, Di Cio S, Dibble M, Gautrot J, Biddle A
F1000research, F1000 Research Ltd vol. 12, 439-439.
15-01-2024
2023

Youssef G, Gammon L, Ambler L, Lunetto S, Scemama A, Cottom H, Piper K, Mackenzie IC et al.
Elife, Elife vol. 12
17-11-2023

Samain R, Maiques O, Monger J, Lam H, Candido J, George S, Ferrari N, KohIhammer L et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 9 (42)
18-10-2023

Scemama A, Tailor A, Di Cio S, Dibble M, Gautrot J, Biddle A
F1000research, F1000 Research Ltd vol. 12, 439-439.
25-04-2023

Biddle A
In Vitro Models, Springer Nature vol. 2 (3-4), 83-88.
01-01-2023
2022

Biddle A
In Vitro Models, Springer Nature vol. 1 (6), 397-398.
17-11-2022

Marles H, Biddle A
Biochemical Pharmacology, Elsevier vol. 204
17-08-2022

Scemama A, Lunetto S, Biddle A
In Vitro Models, Springer Nature vol. 1 (6), 399-403.
27-06-2022

Sahoo S, Ashraf B, Duddu AS, Biddle A, Jolly MK
Clinical & Experimental Metastasis, Springer Nature vol. 39 (2), 279-290.
07-01-2022
2020

Custódio M, Biddle A, Tavassoli M
Oral Oncology, Elsevier vol. 110
01-10-2020
2019

Youssef G, Cottoms H, Piper K, Gammon L, Knowles O, Lunt SA, Mackenzie I, Philpott M et al.
01-09-2019
2018

Jolly MK, Somarelli JA, Sheth M, Biddle A, Tripathi SC, Armstrong AJ, Hanash SM, Bapat SA et al.
Pharmacology & Therapeutics, Elsevier vol. 194, 161-184.
28-09-2018

MACKENZIE IC, Rodrigues MF, Gammon L, RAHMAN M, BIDDLE A, Nunes FD
Oncotarget, Impact Journals
05-02-2018

Knowles O, Doldan P, Hillier-Richardson I, Lunt S, Gammon L, Youssef G, Harwood C, Mackenzie I et al.
01-01-2018
2017

O’Brien-Ball C, Biddle A
Developmental Biology, Elsevier vol. 430 (2), 266-274.
31-07-2017

Vig NK, Gammon L, Peyric E, Rahman M, Biddle A, Mackenzie IC
01-01-2017
2016

BIDDLE A, Gammon L, Liang X, Costea DE, Mackenzie IC
Ebiomedicine, Elsevier: Creative Commons
15-01-2016
2015

Gemenetzidis E, Gammon L, Biddle A, Emich H, Mackenzie IC
Oncotarget, Impact Journals vol. 6 (41), 43964-43977.
02-11-2015

Shigeishi H, Biddle A, Gammon L, Rodini CO, Yamasaki M, Seino S, Sugiyama M, Takechi M et al.
J Oral Pathol Med vol. 44 (3), 201-207.
01-03-2015

Vig N, Mackenzie IC, Biddle A
Journal of Oral Pathology and Medicine, Wiley vol. 44 (9), 649-655.
16-01-2015
2014

Vig N, Biddle A, Gammon L, Emich H, Mackenzie I
British Journal of Oral and Maxillofacial Surgery, Elsevier vol. 52 (8)
01-10-2014
2013

Shigeishi H, Biddle A, Gammon L, Emich H, Rodini CO, Gemenetzidis E, Fazil B, Sugiyama M et al.
Stem Cells vol. 31 (10), 2073-2083.
01-10-2013

Biddle A, Gammon L, Fazil B, Mackenzie IC
Plos One vol. 8 (2)
01-01-2013

Gammon L, Biddle A, Heywood HK, Johannessen AC, Mackenzie IC
Plos One vol. 8 (4)
01-01-2013

Hufbauer M, Biddle A, Borgogna C, Gariglio M, Doorbar J, Storey A, Pfister H, Mackenzie I et al.
Journal of Virology vol. 87 (22), 12158-12165.
01-01-2013
2012

Biddle A, Mackenzie IC
Cancer Metastasis Rev
03-02-2012

VALORANI MG, Montelatici E, Germani A, Biddle A, D'Alessandro D, Strollo R, Patrizi MP, Lazzari L et al.
Cell Proliferation vol. 45 (3), 225-238.
01-01-2012
2011

Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, Costea DE, Mackenzie IC
Cancer Res vol. 71 (15), 5317-5326.
01-08-2011

Gammon L, Biddle A, Fazil B, Harper L, Mackenzie IC
J Oral Pathol Med vol. 40 (2), 143-152.
01-02-2011
2010

Valorani MG, Germani A, Otto WR, Harper L, Biddle A, Khoo CP, Lin WR, Hawa MI et al.
Cell Tissue Res vol. 341 (1), 111-120.
01-07-2010

Harper LJ, Costea DE, Gammon L, Fazil B, Biddle A, Mackenzie IC
Bmc Cancer vol. 10
28-04-2010
2009

Biddle A, Simeoni I, Gurdon JB
Development vol. 136 (16), 2695-2703.
15-08-2009
2005

Dragnev KH, Petty WJ, Shah S, Biddle A, Desai NB, Memoli V, Rigas JR, Dmitrovsky E
Journal of Clinical Oncology, American Society of Clinical Oncology (Asco) vol. 23 (34), 8757-8764.
01-12-2005

Petty WJ, Li N, Biddle A, Bounds R, Nitkin C, Ma Y, Dragnev KH, Freemantle SJ et al.
Journal of The National Cancer Institute, Oxford University Press (Oup) vol. 97 (22), 1645-1651.
16-11-2005
2004

Petty WJ, Dragnev KH, Memoli VA, Ma Y, Desai NB, Biddle A, Davis TH, Nugent WC et al.
Clinical Cancer Research, American Association For Cancer Research (Aacr) vol. 10 (22), 7547-7554.
15-11-2004
Grants


Adrian Biddle and Ana Caetano
£547,066 National Centre for the Replacement, Refinement and Reduction of Animals in Research
01-05-2025 - 30-04-2028

Adrian Biddle
£9,372 Royal College of Surgeons
01-03-2025 - 28-02-2026

Mayson Mustafa and Adrian Biddle
£5,500 ODRT Oral and Dental Research Trust, The
04-11-2024 - 03-11-2025

Ana Caetano and Adrian Biddle
£317,529 MCSBHT Medical College of St Bartholomew's Hospital Trust
01-10-2024 - 31-12-2027

Hazel Screen, Martin Knight, Thomas Iskratsch, Caroline Roney, Yi Sui, David Lee, Julia Shelton, Zion Tse, John Connelly, Adrian Biddle and Lucy Norling
£7,066,811 Engineering and Physical Sciences Research Council
Grant Summary
01-07-2024 - 30-09-2032

Adrian Biddle and Muy-Teck Teh
£298,338 MCSBHT Medical College of St Bartholomew's Hospital Trust
01-09-2021 - 31-01-2026

Paul Coulthard, David Kelsell, Catherine Harwood, Adrian Biddle, Jun Wang and Tracy Connelly
£2,675,828 Barts and the London Charity
01-04-2021 - 31-01-2028

Adrian Biddle
£50,000 Animal Free Research UK
06-06-2022 - 05-06-2025

Adrian Biddle and Jun Wang
£552,481 MRC Medical Research Council
01-09-2021 - 30-06-2025

Adrian Biddle and Julien Gautrot
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research
01-10-2019 - 30-12-2022

Adrian Biddle
£93,000 Oracle Cancer Trust
02-07-2018 - 01-01-2022

Adrian Biddle
£1,940 Animal Free Research UK
04-06-2018 - 03-08-2018