Dr Adrian Biddle
DHT Lecturer in Animal Replacement Science
School of Medicine & Dentistry, Queen Mary University of London
www.qmul.ac.uk/blizard/staff/centre-for-cell-biology-and-cutaneous-research...
cancer stem cells, tumour metastasis, 3D tumour invasion, metastasis on a chip, human tumour specimens, machine learning
Cancer stem cells drive tumour metastasis and therapeutic resistance. Understanding the underlying mechanisms will be crucial if we are to deliver better treatments for cancer, and we model this process using human cancer cell lines in advanced 3D invasion and microfluidic metastasis systems.
We also use human tissue archives, which provide a wealth of information on tumour behaviour in the human body, including data on the clinical course of disease. We have developed new ways of obtaining greater information from these tumour specimens, including simultaneous measurement of multiple cancer stem cell markers and a machine learning approach for prognostic prediction.
- Development of a molecular biomarker test for metastatic cancer stem cells in oral squamous cell car
Principal Investigator: Adrian Biddle
Oracle Cancer Trust (£93,000)
02-07-2018 - 01-07-2021 - A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
Principal Investigator: Adrian Biddle
Co-investigator: Julien Gautrot
NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (£90,000)
01-10-2019 - 30-09-2022