Dr Timothy Hopkins
Versus Arthritis Research Fellow
Queen Mary University of London
Research
Osteoarthritis, Cartilage, Synovium, Organ-on-a-Chip
Underpinning Bioengineering, Musculoskeletal Models
Interests
I am currently working on a Versus Arthritis funded Foundation Fellowship within SEMS. The aim of the fellowship is to develop an organ-on-a-chip model of human cartilage and synovium ‘joint-on-a-chip’ to understand how these tissues interact in the human knee in health and disease. We believe that this interaction plays a key role in the pathobiology of osteoarthritis and influences how individual patients respond to treatment. We are seeking to improve our understanding in these key areas and ultimately to use the joint-on-a-chip to stratify and personalise therapies for osteoarthritis.
Publications
![](/publications/fav.png)
Publications of specific relevance to Predictive in vitro Models
2022
![](/publications/bullet24.png)
Harrison P,
Hopkins T, Hulme C, McCarthy H and Wright K (2022).
Chondrocyte Isolation and Expansion. Cartilage Tissue Engineering , Editors: Stoddart MJ, Della Bella E and Armiento AR.
Springer Nature 10.1007/978-1-0716-2839-3_22021
Hopkins T, Richardson J and Kuiper JH (2021).
Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study. Mdpi Surgeries vol. 2, (3) 286-302.
10.3390/surgeries2030029
Hopkins T, Wright KT, Kuiper NJ, Roberts S, Jermin P, Gallacher P and Kuiper JH (2021).
An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Mdpi Cells vol. 10, (8)
10.3390/cells10081903![](/publications/bullet24.png)
Markides H, Foster NC, McLaren JS,
Hopkins T, Black C, Oreffo ROC, Scammell BE, Echevarria I, White LJ and Haj AJE (2021).
Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Mdpi Cells vol. 10, (7)
10.3390/cells100717762020
![](/publications/bullet24.png)
Mennan C,
Hopkins T, Channon A, Elliott M, Johnstone B, Kadir T, Loughlin J, Peffers M, Pitsillides A, Sofat N, Stewart C, Watt FE, Zeggini E, Holt C, Roberts S and Consortium TON (2020).
The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach. Elsevier Osteoarthritis and Cartilage Open vol. 2, (3)
10.1016/j.ocarto.2020.1000812019
![](/publications/bullet24.png)
Wang J, Wright KT, Perry J, Tins B,
Hopkins T, Hulme C, McCarthy HS, Brown A and Richardson JB (2019).
Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases. Sage Publications Cell Transplantation vol. 28, (7) 924-931.
10.1177/0963689719845328
Grants
![](/publications/fav.png)
Grants of specific relevance to Predictive in vitro Models
Human synovium-cartilage organ-chip for personalised surgical screening - Foundation Fellowship (Tim Hopkins)Knight MM and
Hopkins T£311,203
Versus Arthritis (01-04-2022 - 31-03-2025)
Summary
Production of a human growth plate organ-chip model of skeletal developmentKnight MM and
Hopkins T£199,987
National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-02-2023 - 31-01-2024)
Summary