Dr Timothy Hopkins

Timothy Hopkins

Versus Arthritis Research Fellow

Queen Mary University of London


Osteoarthritis, Cartilage, Synovium, Organ-on-a-Chip

Underpinning Bioengineering, Musculoskeletal Models


I am currently working on a Versus Arthritis funded Foundation Fellowship within SEMS. The aim of the fellowship is to develop an organ-on-a-chip model of human cartilage and synovium ‘joint-on-a-chip’ to understand how these tissues interact in the human knee in health and disease. We believe that this interaction plays a key role in the pathobiology of osteoarthritis and influences how individual patients respond to treatment. We are seeking to improve our understanding in these key areas and ultimately to use the joint-on-a-chip to stratify and personalise therapies for osteoarthritis.


Publications of specific relevance to Predictive in vitro Models


Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM (2023). Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. Iop Publishing  Biomedical Materials  vol. 18, (6) 10.1088/1748-605x/acf976
Hopkins T, Roberts S, Richardson JB, Gallacher P, Bailey A and Kuiper JH (2023). Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. Sage Publications  Orthopaedic Journal of Sports Medicine  vol. 11, (2) 10.1177/23259671231151925


Harrison P, Hopkins T, Hulme C, McCarthy H and Wright K (2022). Chondrocyte Isolation and Expansion. Cartilage Tissue Engineering , Editors: Stoddart MJ, Della Bella E and Armiento AR. Springer Nature  10.1007/978-1-0716-2839-3_2


Hopkins T, Richardson J and Kuiper JH (2021). Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study. Mdpi  Surgeries  vol. 2, (3) 286-302. 10.3390/surgeries2030029
Hopkins T, Wright KT, Kuiper NJ, Roberts S, Jermin P, Gallacher P and Kuiper JH (2021). An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Mdpi  Cells  vol. 10, (8) 10.3390/cells10081903
Markides H, Foster NC, McLaren JS, Hopkins T, Black C, Oreffo ROC, Scammell BE, Echevarria I, White LJ and Haj AJE (2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Mdpi  Cells  vol. 10, (7) 10.3390/cells10071776


Mennan C, Hopkins T, Channon A, Elliott M, Johnstone B, Kadir T, Loughlin J, Peffers M, Pitsillides A, Sofat N, Stewart C, Watt FE, Zeggini E, Holt C, Roberts S and Consortium TON (2020). The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach. Elsevier  Osteoarthritis and Cartilage Open  vol. 2, (3) 10.1016/j.ocarto.2020.100081


Wang J, Wright KT, Perry J, Tins B, Hopkins T, Hulme C, McCarthy HS, Brown A and Richardson JB (2019). Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases. Sage Publications  Cell Transplantation  vol. 28, (7) 924-931. 10.1177/0963689719845328


Grants of specific relevance to Predictive in vitro Models
Human synovium-cartilage organ-chip for personalised surgical screening - Foundation Fellowship (Tim Hopkins)
Knight MM and Hopkins T
£311,203 Versus Arthritis (01-04-2022 - 31-03-2025)

Production of a human growth plate organ-chip model of skeletal development
Knight MM and Hopkins T
£199,987 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-02-2023 - 31-01-2024)