Dr Simon McArthur

Simon McArthur

Senior Lecturer in Neuroscience and Pharmacology

Dental Institute
Faculty of Medicine and Dentistry, Queen Mary University of London


Blood-brain barrier, Gut-brain axis, Gut microbiota, Neuroinflammation, Dementia, Diet

Cardiovascular Models, Infectious Disease and Inflammation Models, Neuronal Models


We are interested in understanding the mechanisms underlying the diet-gut microbiota-brain axis, and how gut microbes can influence brain function in health and disease. We employ a range of different in vitro neural and neurovascular models to study the pharmacology of gut microbe-derived mediators upon the brain, allowing identification of target pathways and systems for potential therapeutic intervention.


Publications of specific relevance to Predictive in vitro Models


Wickstead ES, Elliott BT, Pokorny S, Biggs C, Getting SJ and Mcarthur S (2023). Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity. Mdpi  International Journal of Molecular Sciences  vol. 24, (21) 15996-15996. 10.3390/ijms242115996
McArthur S (2023). The gut microbe‐derived methylamine TMAO protects against neuroinflammation through restraint of pro‐inflammatory glial behaviour. Wiley  Alzheimer\'s & Dementia  vol. 19, (S1) 10.1002/alz.066817
Mcarthur S (2023). Regulation of Physiological Barrier Function by the Commensal Microbiota. Mdpi  Life  10.3390/life13020396
Stachulski AV, Knausenberger TB-A, Shah SN, Hoyles L and McArthur S (2023). A host-gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo. Tissue Barriers  vol. 11, (1) 10.1080/21688370.2022.2073175


Wickstead ES, Solito E and Mcarthur S (2022). Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class. Mdpi  Life  vol. 12, (12) 10.3390/life12122009


Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD, O'Riordan CE, Ferorelli D, Dell'Erba A, Kieswich J, Reutelingsperger C, Maiorano E, Yaqoob M, Thiemermann C, Baragetti A, Catapano AL, Norata GD, Marelli‐Berg F, Virgintino D and Solito E (2021). Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues. Wiley  The Faseb Journal  vol. 36, (1) 10.1096/fj.202101297r
Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S, Carvalho AL, Carding SR, Muller M, Glen RC, Vauzour D and Mcarthur S (2021). Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide. Biomed Central  Microbiome  10.1186/s40168-021-01181-z
Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D, McArthur S, Pike I and Malaspina A (2021). Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders. Oxford University Press (Oup)  Brain Communications  vol. 3, (3) 10.1093/braincomms/fcab148
Wickstead ES, Irving MA, Getting SJ and McArthur S (2021). Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer’s disease treatment. Wiley  The Febs Journal  vol. 289, (7) 1801-1822. 10.1111/febs.15861


Pearson JRD, Cuzzubbo S, McArthur S, Durrant LG, Adhikaree J, Tinsley CJ, Pockley AG and McArdle SEB (2020). Immune Escape in Glioblastoma Multiforme and the Adaptation of Immunotherapies for Treatment. Frontiers  Frontiers in Immunology  vol. 11, 10.3389/fimmu.2020.582106
Wickstead ES, Karim HA, Manuel RE, Biggs CS, Getting SJ and McArthur S (2020). Reversal of β-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3. Hindawi  Oxidative Medicine and Cellular Longevity  vol. 2020, 10.1155/2020/2139192
Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, Mcarthur S and Solito E (2020). Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier. Biomed Central  Journal of Neuroinflammation  10.1186/s12974-020-01810-8
McArthur S, Gobbetti T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP, Perretti M and Mounier R (2020). Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation. American Society For Clinical Investigation  Journal of Clinical Investigation  10.1101/375709


Lopez Tremoleda J, Wall J, Naganathar V, Praditsuktavorn B, Bugg O, Mcarthur S, Thiemermann C and Brohi K (2019). Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity. Frontiers Media  Frontiers in Immunology  vol. 10, 10.3389/fimmu.2019.02774
Wan H, Li X, Ahmad U, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G, Mcarthur S and Parkinson E (2019). Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells. Elsevier  Mechanisms of Ageing and Development  10.1016/j.mad.2019.111174
Loiola RA, Wickstead ES, Solito E and Mcarthur S (2019). Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1. Frontiers Media  Frontiers in Endocrinology  10.3389/fendo.2019.00420


Barrios-Silva LV, Parnell M, Shinwari ZB, Chaudhary GA, Xenofontos T, van Bekhoven A, MCARTHUR S and Elliott BT (2018). Activin sub-family peptides predict chronological age in humans. Wiley  Physiological Reports  vol. 6, (17) e13823-e13823. 10.14814/phy2.13823
MCARTHUR S, GOBBETTI T, Juban G, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa J, Reutelingsperger C, PERRETTI M and Mounier R (2018). Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation. Biorxiv  vol. 375709, (375709) 1-1. 10.1101/375709
Hoyles L, Snelling T, Umlai U-K, Nicholson JK, Carding SR, Glen RC and MCARTHUR S (2018). Microbiome-host systems interactions: Protective effects of propionate upon the bloodbrain barrier. Biomed Central  Bmc Microbiome  vol. 6, 55-55. 10.1186/s40168-018-0439-y


McArthur S, Loiola RA, Maggioli E, Errede M, Virgintino D and SOLITO E (2016). The restorative role of annexin A1 at the blood–brain barrier. Biomed Central  Fluids and Barriers of The Cns  vol. 13, (17) 10.1186/s12987-016-0043-0
Virdee K, Kentrop J, Jupp B, Venus B, Hensman D, McArthur S, Wilkinson J, Robbins TW, Gillies G and Dalley JW (2016). Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory. Springer Nature  Psychopharmacology  vol. 233, (21-22) 3751-3761. 10.1007/s00213-016-4405-8


Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DHM, Reutelingsperger CPM, Yaqoob M and Solito E (2015). Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Elsevier  Brain Behavior and Immunity  vol. 51, 212-222. 10.1016/j.bbi.2015.08.020
McArthur S, Gobbetti T, Kusters DHM, Reutelingsperger CP, Flower RJ and Perretti M (2015). Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. The American Association of Immunologists  The Journal of Immunology  vol. 195, (3) 1139-1151. 10.4049/jimmunol.1500733
McArthur S, Pienaar IS, Siddiqi SM and Gillies GE (2015). Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment. Springer Nature  Brain Structure and Function  vol. 221, (5) 2459-2475. 10.1007/s00429-015-1049-0
Shende VH, McArthur S, Gillies GE and Opacka-Juffry J (2015). Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone. Hindawi  Neural Plasticity  vol. 2015, 10.1155/2015/694347


Thompson D, McArthur S, Hislop JN, Flower RJ and Perretti M (2014). Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: association with cell protection from apoptosis. J Biol Chem  vol. 289, (52) 36166-36178. 10.1074/jbc.M114.612630
Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 111, (52) 18685-18690. 10.1073/pnas.1410938111
Gillies GE, Virdee K, McArthur S and Dalley JW (2014). Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis. Neuroscience  vol. 282, 69-85. 10.1016/j.neuroscience.2014.05.033
Virdee K, McArthur S, Brischoux F, Caprioli D, Ungless MA, Robbins TW, Dalley JW and Gillies GE (2014). Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience. Neuropsychopharmacology  vol. 39, (2) 339-350. 10.1038/npp.2013.196
Locatelli I, Sutti S, Jindal A, Vacchiano M, Bozzola C, Reutelingsperger C, Kusters D, Bena S, Parola M, Paternostro C, Bugianesi E, McArthur S, Albano E and Perretti M (2014). Endogenous Annexin A1 Is a Novel Protective Determinant in Nonalcoholic Steatohepatitis in Mice. Hepatology  vol. 60, (2) 531-544. 10.1002/hep.27141


Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ and Perretti M (2013). Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A  vol. 110, (45) 18232-18237. 10.1073/pnas.1308253110
Cash JL, Bena S, Headland SE, McArthur S, Brancaleone V and Perretti M (2013). Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. Embo Rep  vol. 14, (11) 999-1007. 10.1038/embor.2013.138
Nadkarni S and McArthur S (2013). Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity. Curr Opin Pharmacol  vol. 13, (4) 576-581. 10.1016/j.coph.2013.05.007
Katsouri L, Vizcaychipi MP, McArthur S, Harrison I, Suárez-Calvet M, Lleo A, Lloyd DG, Ma D and Sastre M (2013). Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease. Neurobiol Aging  vol. 34, (4) 1105-1115. 10.1016/j.neurobiolaging.2012.09.010
Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J, Christian HC, Weksler BB, Malaspina A and Solito E (2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc Natl Acad Sci U S A  vol. 110, (3) 832-841. 10.1073/pnas.1209362110


Dalli J, Montero-Melendez T, McArthur S and Perretti M (2012). Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol  vol. 3, 10.3389/fphar.2012.00028


McArthur S, Robinson IC and Gillies GE (2011). Novel ontogenetic patterns of sexual differentiation in arcuate nucleus GHRH neurons revealed in GHRH-enhanced green fluorescent protein transgenic mice. Endocrinology  vol. 152, (2) 607-617. 10.1210/en.2010-0798
McArthur S and Gillies GE (2011). Peripheral vs. Central Sex Steroid Hormones in Experimental Parkinson's Disease. Front Endocrinol (Lausanne)  vol. 2, 10.3389/fendo.2011.00082


McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE and Solito E (2010). Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. J Immunol  vol. 185, (10) 6317-6328. 10.4049/jimmunol.1001095
Gillies GE and McArthur S (2010). Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacol Rev  vol. 62, (2) 155-198. 10.1124/pr.109.002071
Gillies GE and McArthur S (2010). Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: A contribution to sex-specific neuroprotection by estrogens. Horm Behav  vol. 57, (1) 23-34. 10.1016/j.yhbeh.2009.06.002
Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N and Flower RJ (2010). Anti-allergic drugs and the Annexin-A1 system. Pharmacol Rep  vol. 62, (3) 511-517. 10.1016/s1734-1140(10)70307-8


McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J and Solito E (2009). Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. Faseb J  vol. 23, (11) 4000-4010. 10.1096/fj.09-131391
Yazid S, Solito E, Christian H, McArthur S, Goulding N and Flower R (2009). Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochem Pharmacol  vol. 77, (12) 1814-1826. 10.1016/j.bcp.2009.03.010


McArthur S, Prasongchean W, Gillies G and Solito E (2008). A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis. Fund Clin Pharmacol  vol. 22, 23-23.
Solito E, McArthur S, Christian H, Gavins F, Buckingham JC and Gillies GE (2008). Annexin A1 in the brain--undiscovered roles? Trends Pharmacol Sci  vol. 29, (3) 135-142. 10.1016/j.tips.2007.12.003


McArthur S, McHale E and Gillies GE (2007). The size and distribution of midbrain dopaminergic populations are permanently altered by perinatal glucocorticoid exposure in a sex- region- and time-specific manner. Neuropsychopharmacology  vol. 32, (7) 1462-1476. 10.1038/sj.npp.1301277
McArthur S, Murray HE, Dhankot A, Dexter DT and Gillies GE (2007). Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition. J Neurochem  vol. 100, (3) 678-692. 10.1111/j.1471-4159.2006.04226.x


Gillies G, McArthur S and McHale E (2006). Sex dimorphisms in the 3D cytoarchitecture of the adult VTA and permanent alterations by glucocorticoid exposure in late gestation. Elsevier  Frontiers in Neuroendocrinology  vol. 27, (1) 95-96. 10.1016/j.yfrne.2006.03.219
McArthur S, Siddique Z-L, Christian HC, Capone G, Theogaraj E, John CD, Smith SF, Morris JF, Buckingham JC and Gillies GE (2006). Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats. Endocrinology  vol. 147, (4) 1904-1915. 10.1210/en.2005-1496


McArthur S, McHale E, Dalley JW, Buckingham JC and Gillies GE (2005). Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure. J Neuroendocrinol  vol. 17, (8) 475-482. 10.1111/j.1365-2826.2005.01331.x


Gillies GE, Murray HE, Dexter D and McArthur S (2004). Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease. Pharmacol Biochem Behav  vol. 78, (3) 513-522. 10.1016/j.pbb.2004.04.022


Murray HE, Pillai AV, McArthur SR, Razvi N, Datla KP, Dexter DT and Gillies GE (2003). Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females. Elsevier  Neuroscience  vol. 116, (1) 213-222. 10.1016/s0306-4522(02)00578-x


Grants of specific relevance to Predictive in vitro Models
Establishing a link between the gut-brain axis and Alzheimer's disease
McArthur S
£46,518 Alzheimer's Research UK (01-09-2016 - 31-08-2018)