Dr Suzanne Eldridge
Senior Lecturer of Musculoskeletal Regenerative Medicine
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Cartilage, Osteoarthritis, Pain, Drug development
Interests
In vitro (micromass 3D culture) and ex vivo (explants, joint on a chip) models of cartilage regeneration, degeneration, injury and diseasePublications
2025
ABS0240 MECHANO-ACTIVATED CHONDROPROGENITORS (MACS) DERIVED FROM ARTICULAR CHONDROCYTES, WHICH DRIVE INTRINSIC CARTILAGE REPAIRZhu L, Muhammad H, Perry TA, Ardasheva A, Symons RA, Mcclure JJ, Kania K, Clark SM et al.
Annals of The Rheumatic Diseases, Elsevier vol. 84, 1737-1738.
01-06-2025
2024
POS0217 AGRIN HAS A DIRECT ANALGESIC EFFECT IN OSTEOARTHRITIS MODELS.Eldridge S, Dajas-Bailador F, Chapman V, Bharde S, Sikandar S, Cici D, Dell’accio F
01-06-2024
069 INTRA-ARTICULAR ADMINISTRATION OF AGRIN INDUCES RAPID AND SUSTAINED PAIN RELIEF IN OSTEOARTHRITISDajas-Bailador F, Chapman V, Lucci C, Rathbone A, Bharde S, Sikandar S, Dell'Accio F, Eldridge S
Osteoarthritis and Cartilage, Elsevier vol. 32
01-04-2024
2022
Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokineCaxaria S, Kouvatsos N, Eldridge SE, Alvarez-Fallas M, Thorup A-S, Cici D, Barawi A, Arshed A et al.
Embo Molecular Medicine, Embo Press
12-12-2022
A Mouse Model of Acute Cartilage Injury and RepairThorup A-S, Dell’Accio F, Eldridge SE
Methods in Molecular Biology, Springer Nature vol. 2598, 337-344.
11-11-2022
AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTSEldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M et al.
Annals of The Rheumatic Diseases, Elsevier vol. 81
01-06-2022
BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLINGThorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G et al.
Osteoarthritis and Cartilage, Elsevier vol. 30
01-04-2022
In vivo potency assay for the screening of bioactive molecules on cartilage formationTHORUP A, Caxaria S, Dell'Accio F, Thomas BL, Suleman Y, Nalesso G, Luyten FP, Dell'Accio F et al.
Lab Animal, Nature Research
31-03-2022
2021
OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITISThorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al.
Annals of The Rheumatic Diseases, Elsevier vol. 80, 120-121.
01-06-2021
AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVOEldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B et al.
Annals of The Rheumatic Diseases vol. 80 (Suppl 1), 1052.1-101052.
19-05-2021
WNT3A‐loaded exosomes enable cartilage repairThomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup A, Nalesso G, Caxaria S, Barawi A et al.
Journal of Extracellular Vesicles, Wiley vol. 10 (7)
01-05-2021
2020
ROR2 blockade as a therapy for osteoarthritisThorup A-S, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al.
Science Translational Medicine, American Association For The Advancement of Science vol. 12 (561)
16-09-2020
Agrin induces long term osteochondral regeneration by supporting repair morphogenesisEldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B et al.
Science Translational Medicine, American Association For The Advancement of Science vol. 12 (559)
02-09-2020
Lessons from joint development for cartilage repair in the clinicThorup A, Dell'Accio F, Eldridge SE
Developmental Dynamics, Wiley vol. 250 (3), 360-376.
25-08-2020
2018
MMP‐3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomyPengas I, Eldridge S, Assiotis A, McNicholas M, Mendes JE, Laver L
Journal of Experimental Orthopaedics, Wiley vol. 5 (1)
15-06-2018
2017
Agrin inhibits canonical WNT signalling through LRP4Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al.
01-04-2017
WNT16 is up-regulated in the joint following inflammationThomas BL, Nalesso G, Eldridge SE, Pitzalis C, Dell'accio F
01-04-2017
A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivoThorup A-S, Eldridge SE, Caxaria S, Nalesso G, Thomas BL, Pitzalis C, Luyten F, Dell'Accio F
01-04-2017
2016
Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivoEldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al.
Annals of The Rheumatic Diseases, Elsevier Bv vol. 75 (6), 1228-1235.
01-06-2016
WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritisnalesso, thomas, sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup, Dale L et al.
Annals of Rheumatic Diseases
04-05-2016
MMP3 cleaves agrin in cartilage and reduces its chondrogenic potencyEldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F
01-04-2016
Pharmacological Blockade of CAMKII is Detrimental for Osteoarthritis ProgressionNalesso G, Wagner K, Bertrand J, Sherwood JC, Thomas BL, Eldridge SE, Pitzalis C, Dell'Accio F
2016 OARSI World Congress on Osteoarthritis.
20-03-2016
2014
Cellular and molecular mechanisms of cartilage damage and repairSherwood JC, Bertrand J, Eldridge SE, Dell’Accio F
Drug Discovery Today, Elsevier vol. 19 (8), 1172-1177.
28-05-2014
Agrin expression is downregulated in OA and is required for chondrocyte differentiationEldridge S, Vicente-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F
01-01-2014
2013
Wnt5a/CaMKII pathway is activated in osteoarthritis and promotes loss of chondrocyte phenotypeNalesso G, Thomas BL, Eldridge SE, Wagner K, Sherwood J, Bertrand J, Pap T, Pitzalis C et al.
01-04-2013
Agrin expression is downregulated in OA and is required for chondrocyte differentiationEldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F
Osteoarthritis and Cartilage, Elsevier Bv vol. 21, S112-S113.
01-04-2013
Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritisNalesso G, THORUP A-S, Eldridge S, De Palma A, KAUR A, Peddireddi K, Blighe K, Rana S et al.
Scientific Reports, Nature Publishing Group
Grants
GCP2T Versus proof of conceptFrancesco Dell'Accio, Suzanne Eldridge and Xavier Griffin
£199,966 Versus Arthritis
01-11-2025 - 31-10-2027
Identification of patients at risk of OA who will benefit from Agrin treatmentSuzanne Eldridge, Xavier Griffin, Francesco Dell'Accio and Qianni Zhang
£1,186,732 Versus Arthritis
01-10-2025 - 30-09-2029
ReFleks - start-up accelerationSuzanne Eldridge and Francesco Dell'Accio
£101,631 UK Research & Innovation
01-04-2025 - 31-12-2025
Investigating the therapeutic potential of Agrin in osteoarthritisSuzanne Eldridge
£91,653 Daphne Jackson Trust, the
02-05-2023 - 01-05-2026
Agrin: harnessing mechanisms of limb development for joint regeneration in patientsSuzanne Eldridge
£398,831 AR-UK Versus Arthritis
01-12-2021 - 30-11-2026
Development of an App to engage patients at risk of osteoarthritisSuzanne Eldridge and Francesco Dell'Accio
£26,620 ESRC Economic and Social Research Council
01-09-2023 - 31-08-2024
Treating for Obesity Induced OsteoarthritisSuzanne Eldridge
£20,000 Royal Society
21-03-2022 - 28-02-2024
Is Agrin necessary for cartilage health?Suzanne Eldridge
£37,494 Rosetrees Trust
06-05-2019 - 28-02-2023
UCB PhD studentship for Prof Francesco Dell Accio- Ms Aida BarawiFrancesco Dell'Accio, Suzanne Eldridge, Jenofer Sithara Sirajudeen, Anne Marie Stephen and Bethan Thomas
£106,818 UCB Pharma SPRL
01-10-2018 - 30-06-2023