Dr Suzanne Eldridge

Suzanne Eldridge

Senior Lecturer of Musculoskeletal Regenerative Medicine

The William Harvey Research Institute
Queen Mary University of London
07947 852218

Research

Cartilage, Osteoarthritis, Pain, Drug development

Interests

In vitro (micromass 3D culture) and ex vivo (explants, joint on a chip) models of cartilage regeneration, degeneration, injury and disease

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

POS0217 AGRIN HAS A DIRECT ANALGESIC EFFECT IN OSTEOARTHRITIS MODELS.
Eldridge S, Dajas-Bailador F, Chapman V, Bharde S, Sikandar S, Cici D, Dell’accio F
 
01-06-2024
069 INTRA-ARTICULAR ADMINISTRATION OF AGRIN INDUCES RAPID AND SUSTAINED PAIN RELIEF IN OSTEOARTHRITIS
Dajas-Bailador F, Chapman V, Lucci C, Rathbone A, Bharde S, Sikandar S, Dell'Accio F, Eldridge S
Osteoarthritis and Cartilage, Elsevier vol. 32 
01-04-2024

2022

Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine
Caxaria S, Kouvatsos N, Eldridge SE, Alvarez-Fallas M, Thorup A-S, Cici D, Barawi A, Arshed A et al.
Embo Molecular Medicine, Embo Press 
12-12-2022
A Mouse Model of Acute Cartilage Injury and Repair
Thorup A-S, Dell’Accio F, Eldridge SE
Methods in Molecular Biology, Springer Nature vol. 2598, 337-344.  
11-11-2022
AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS
Eldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M et al.
Annals of The Rheumatic Diseases, Elsevier vol. 81 
01-06-2022
BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING
Thorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G et al.
Osteoarthritis and Cartilage, Elsevier vol. 30 
01-04-2022
In vivo potency assay for the screening of bioactive molecules on cartilage formation
THORUP A, Caxaria S, Dell'Accio F, Thomas BL, Suleman Y, Nalesso G, Luyten FP, Dell'Accio F et al.
Lab Animal, Nature Research 
31-03-2022

2021

OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS
Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al.
Annals of The Rheumatic Diseases, Elsevier vol. 80, 120-121.  
01-06-2021
AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B et al.
Annals of The Rheumatic Diseases vol. 80 (Suppl 1), 1052.1-101052.  
19-05-2021
WNT3A‐loaded exosomes enable cartilage repair
Thomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup A, Nalesso G, Caxaria S, Barawi A et al.
Journal of Extracellular Vesicles, Wiley vol. 10 (7) 
01-05-2021
Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis
Nalesso G, Thorup A-S, Eldridge SE, De Palma A, Kaur A, Peddireddi K, Blighe K, Rana S et al.
Scientific Reports, Springer Nature vol. 11 (1) 
11-03-2021

2020

ROR2 blockade as a therapy for osteoarthritis
Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al.
Science Translational Medicine, American Association For The Advancement of Science vol. 12 (561) 
16-09-2020
Agrin induces long term osteochondral regeneration by supporting repair morphogenesis
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B et al.
Science Translational Medicine, American Association For The Advancement of Science vol. 12 (559) 
02-09-2020
Lessons from joint development for cartilage repair in the clinic
Thorup A, Dell'Accio F, Eldridge SE
Developmental Dynamics, Wiley vol. 250 (3), 360-376.  
25-08-2020

2018

MMP‐3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy
Pengas I, Eldridge S, Assiotis A, McNicholas M, Mendes JE, Laver L
Journal of Experimental Orthopaedics, Wiley vol. 5 (1) 
15-06-2018

2017

Agrin inhibits canonical WNT signalling through LRP4
Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al.
 
01-04-2017
WNT16 is up-regulated in the joint following inflammation
Thomas BL, Nalesso G, Eldridge SE, Pitzalis C, Dell'accio F
 
01-04-2017
A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo
Thorup A-S, Eldridge SE, Caxaria S, Nalesso G, Thomas BL, Pitzalis C, Luyten F, Dell'Accio F
 
01-04-2017

2016

Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo
Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al.
Annals of The Rheumatic Diseases, Elsevier Bv vol. 75 (6), 1228-1235.  
01-06-2016
WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis
nalesso, thomas, sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup, Dale L et al.
Annals of Rheumatic Diseases 
04-05-2016
MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency
Eldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F
 
01-04-2016
Pharmacological Blockade of CAMKII is Detrimental for Osteoarthritis Progression
Nalesso G, Wagner K, Bertrand J, Sherwood JC, Thomas BL, Eldridge SE, Pitzalis C, Dell'Accio F
2016 OARSI World Congress on Osteoarthritis. 
20-03-2016

2014

Cellular and molecular mechanisms of cartilage damage and repair
Sherwood JC, Bertrand J, Eldridge SE, Dell’Accio F
Drug Discovery Today, Elsevier vol. 19 (8), 1172-1177.  
28-05-2014
Agrin expression is downregulated in OA and is required for chondrocyte differentiation
Eldridge S, Vicente-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F
 
01-01-2014

2013

Wnt5a/CaMKII pathway is activated in osteoarthritis and promotes loss of chondrocyte phenotype
Nalesso G, Thomas BL, Eldridge SE, Wagner K, Sherwood J, Bertrand J, Pap T, Pitzalis C et al.
 
01-04-2013
Agrin expression is downregulated in OA and is required for chondrocyte differentiation
Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F
Osteoarthritis and Cartilage, Elsevier Bv vol. 21, S112-S113.  
01-04-2013

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconReFleks - start-up acceleration
Suzanne Eldridge and Francesco Dell'Accio
£101,631 UK Research & Innovation
01-04-2025 - 31-12-2025
bullet iconInvestigating the therapeutic potential of Agrin in osteoarthritis
Suzanne Eldridge
£91,653 Daphne Jackson Trust, the
02-05-2023 - 01-05-2026
bullet iconAgrin: harnessing mechanisms of limb development for joint regeneration in patients
Suzanne Eldridge
£398,831 AR-UK Versus Arthritis
01-12-2021 - 30-11-2026

bullet iconDevelopment of an App to engage patients at risk of osteoarthritis
Suzanne Eldridge and Francesco Dell'Accio
£26,620 ESRC Economic and Social Research Council
01-09-2023 - 31-08-2024
bullet iconTreating for Obesity Induced Osteoarthritis
Suzanne Eldridge
£20,000 Royal Society
21-03-2022 - 28-02-2024
bullet iconIs Agrin necessary for cartilage health?
Suzanne Eldridge
£37,494 Rosetrees Trust
06-05-2019 - 28-02-2023
bullet iconUCB PhD studentship for Prof Francesco Dell Accio- Ms Aida Barawi
Francesco Dell'Accio, Suzanne Eldridge, Jenofer Sithara Sirajudeen, Anne Marie Stephen and Bethan Thomas
£106,818 UCB Pharma SPRL
01-10-2018 - 30-06-2023