Prof Paula Longhi
Professor in Dendritic Cell Biology
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Cardio-immunology, Adipose tissue, Adaptive Immune responses, Cardiomyocytes
Interests
Immune assays (e.g. T cell proliferation) ,T cell-cardiomyocytes and -cardiac fibroblast interactions.Publications
2024
Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillationVyas V, Sandhar B, Keane JM, Wood EG, Blythe H, Jones A, Shahaj E, Fanti S et al.
Nature Cardiovascular Research, Springer Science and Business Media Llc vol. 3 (9), 1067-1082.
23-08-2024
2023
The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing.Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M et al.
Nature Metabolism, Nature Research
26-10-2023
2022
Circulating c-Met–Expressing Memory T Cells Define Cardiac AutoimmunityFanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS et al.
Circulation, Wolters Kluwer vol. 146 (25), 1930-1945.
23-11-2022
2021
Obesity and diabetes are major risk factors for epicardial adipose tissue inflammationVyas V, Blythe H, Wood EG, Sandhar B, Sarker S-J, Balmforth D, Ambekar SG, Yap J et al.
Jci Insight, American Society For Clinical Investigation vol. 6 (16)
23-08-2021
Isolation of stromal vascular fraction cell suspensions from mouse and human adipose tissues for downstream applicationsHearnden R, Sandhar B, Vyas V, Longhi MP
Star Protocols, Elsevier vol. 2 (2)
30-03-2021
Delayed-onset myocarditis following COVID-19Bajaj R, Sinclair HC, Patel K, Low B, Pericao A, Manisty C, Guttmann O, Zemrak F et al.
The Lancet Respiratory Medicine, Elsevier vol. 9 (4), e32-e34.
19-02-2021
2020
HIF1α activation in dendritic cells under sterile conditions promotes an anti-inflammatory phenotype through accumulation of intracellular lipidsWood EG, Macdougall CE, Blythe H, Clément M, Colas RA, Dalli J, Marelli-Berg F, Longhi MP
Scientific Reports, Springer Nature vol. 10 (1)
30-11-2020
Inflammation and adiposity: new frontiers in atrial fibrillationVyas V, Hunter RJ, Longhi MP, Finlay MC
Ep Europace, Oxford University Press (Oup) vol. 22 (11), 1609-1618.
02-10-2020
2019
Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in MiceMacdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Charalambous M et al.
Diabetes, American Diabetes Association vol. 68 (7), 1473-1484.
02-05-2019
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPRMogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.
Cell, Elsevier vol. 177 (5), 1201-1216.e19.
25-04-2019
Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018))Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.
Cell vol. 178 (1), 263-263.
25-04-2019
Adipose tissue dendritic cells in steady‐stateMacdougall CE, Longhi MP
Immunology, Wiley vol. 156 (3), 228-234.
13-01-2019
2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activationBonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P et al.
Nature Communications, Springer Science and Business Media Llc vol. 9 (1)
06-08-2018
Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell SubsetsMacdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L et al.
Cell Metabolism, Elsevier vol. 27 (3), 588-601.e4.
01-03-2018
2017
Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of TraumaCABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al.
Plos Medicine, Public Library of Science (Plos)
17-07-2017
Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al.
Plos Med vol. 14 (7)
01-07-2017
Obesity-induced metabolic stress leads to biased effector memory CD4+ T cell differentiation via PI3K p110δ/Akt-mediated signalsMAURO C, Smith J, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Cermenati G et al.
Cell Metabolism, Elsevier (Cell Press)
09-02-2017
2016
The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, Patel R, Gautier EL et al.
Immunity, Elsevier Inc. vol. 45 (6), 1205-1218.
20-12-2016
Dendritic cells and adipose tissueRajan SS, Longhi MP
Immunology, Wiley vol. 149 (4), 353-361.
23-08-2016
2014
Classical Flt3L-dependent dendritic cells control immunity to protein vaccineAnandasabapathy N, Feder R, Mollah S, Tse S-W, Longhi MP, Mehandru S, Matos I, Cheong C et al.
Journal of Experimental Medicine, Rockefeller University Press vol. 211 (9), 1875-1891.
18-08-2014
Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC StimulationPantel A, Teixeira A, Haddad E, Wood EG, Steinman RM, Longhi MP
Plos Biology, Public Library of Science (Plos) vol. 12 (1)
01-01-2014
2013
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cellsBarbuto S, Idoyaga J, Vila-Perelló M, Longhi MP, Breton G, Steinman RM, Muir TW
Nature Chemical Biology, Springer Nature vol. 9 (4), 250-256.
17-02-2013
2012
Dendritic cell‐targeted protein vaccines: a novel approach to induce T‐cell immunityTrumpfheller C, Longhi MP, Caskey M, Idoyaga J, Bozzacco L, Keler T, Schlesinger SJ, Steinman RM
Journal of Internal Medicine, Wiley vol. 271 (2), 183-192.
04-01-2012
2011
A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T‐cell immunity in vivoPantel A, Cheong C, Dandamudi D, Shrestha E, Mehandru S, Brane L, Ruane D, Teixeira A et al.
European Journal of Immunology, Wiley vol. 42 (1), 101-109.
12-12-2011
2010
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell AreasCheong C, Matos I, Choi J-H, Dandamudi DB, Shrestha E, Longhi MP, Jeffrey KL, Anthony RM et al.
Cell, Elsevier vol. 143 (3), 416-429.
01-10-2010
2009
HIV gag protein is efficiently cross‐presented when targeted with an antibody towards the DEC‐205 receptor in Flt3 ligand‐mobilized murine DCBozzacco L, Trumpfheller C, Huang Y, Longhi MP, Shimeliovich I, Schauer JD, Park CG, Steinman RM
European Journal of Immunology, Wiley vol. 40 (1), 36-46.
30-12-2009
CD59 Blockade Enhances Antigen-Specific CD4+ T Cell Responses in Humans: A New Target for Cancer Immunotherapy?Sivasankar B, Longhi MP, Gallagher KME, Betts GJ, Morgan BP, Godkin AJ, Gallimore AM
The Journal of Immunology, Oxford University Press (Oup) vol. 182 (9), 5203-5207.
01-05-2009
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant.LONGHI PM, Trumpfheller C, Idoyaga J, Caskey M, Matos I, Kluger C, Salazar AM, Colonna M et al.
J Exp Med vol. 206 (7), 1589-1602.
01-01-2009
2008
Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T CellsLonghi MP, Wright K, Lauder SN, Nowell MA, Jones GW, Godkin AJ, Jones SA, Gallimore AM
Plos Pathogens, Public Library of Science (Plos) vol. 4 (2)
29-02-2008
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccineTrumpfheller C, Caskey M, Nchinda G, Longhi MP, Mizenina O, Huang Y, Schlesinger SJ, Colonna M et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 105 (7), 2574-2579.
19-02-2008
CD62L (L-Selectin) Down-Regulation Does Not Affect Memory T Cell Distribution but Failure to Shed Compromises Anti-Viral ImmunityRichards H, Longhi MP, Wright K, Gallimore A, Ager A
The Journal of Immunology, Oxford University Press (Oup) vol. 180 (1), 198-206.
01-01-2008
2007
CD59a deficiency exacerbates influenza‐induced lung inflammation through complement‐dependent and ‐independent mechanismsLonghi MP, Williams A, Wise M, Morgan BP, Gallimore A
European Journal of Immunology, Wiley vol. 37 (5), 1266-1274.
19-04-2007
CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigensSivasankar B, Donev RM, Longhi MP, Hughes TR, Davies R, Cole DS, Morgan BP, Marchbank KJ
Molecular Immunology, Elsevier vol. 44 (11), 2978-2987.
12-02-2007
2006
Expression of Glycosylphosphatidylinositol-Anchored CD59 on Target Cells Enhances Human NK Cell-Mediated CytotoxicityOmidvar N, Wang ECY, Brennan P, Longhi MP, Smith RAG, Morgan BP
The Journal of Immunology, Oxford University Press (Oup) vol. 176 (5), 2915-2923.
01-03-2006
Holding T cells in check – a new role for complement regulators?Longhi MP, Harris CL, Morgan BP, Gallimore A
Trends in Immunology, Elsevier vol. 27 (2), 102-108.
10-01-2006
2005
Cutting Edge: Murine CD59a Modulates Antiviral CD4+ T Cell Activity in a Complement-Independent MannerLonghi MP, Sivasankar B, Omidvar N, Morgan BP, Gallimore A
The Journal of Immunology, Oxford University Press (Oup) vol. 175 (11), 7098-7102.
01-12-2005
2004
Complement: central to innate immunity and bridging to adaptive responsesMorgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM
07-12-2004
Grants
Investigating the topography of adaptive immunity in the cardiovascular system: Basic mechanisms and therapeutic potential (renewal)Federica Marelli-Berg and Paula Longhi
£1,332,534 BHF British Heart Foundation
01-01-2021 - 31-12-2025
Identification of metabolites and metabolic signatures to define T cell status during expansion.Katiuscia Bianchi and Paula Longhi
£49,923 RE Research England
01-06-2021 - 28-02-2022
Atrial fibrillation FULLPaula Longhi and Ross Hunter
£206,146 Barts and the London Charity
01-10-2018 - 30-09-2022
Intracellular lipid accumulation and Immune dysfunction in VHL syndromePaula Longhi
£23,440 Barts and the London Charity
01-08-2018 - 28-02-2020
Investigating the role of CD103 Dendritic cells in controlling adipose tissue inflammationPaula Longhi
£208,467 BHF British Heart Foundation
01-12-2016 - 30-11-2018