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Dr Lucy Norling

Lucy Norling

Versus Arthritis Senior Fellow /
(Responsible for ECR Engagement, Social Media and Public Engagement)

Centre for Biochemical Pharmacology
School of Medicine and Dentistry

www.qmul.ac.uk/whri/people/academic-staff/items/norlinglucy.html

ORCiD

Research

Musculoskeletal, Leukocyte Trafficking, Omega-3, Chemotaxis

Interests

My research group is interested in how omega-3 derived lipid mediators can protect and repair joint tissues. I have a keen interest in the development of human in vitro models to mimic various aspects of the inflammatory response including leukocyte-endothelial interactions, cell chemotaxis, phagocytosis and efferocytosis as well as the development of musculoskeletal models.

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Norling LV and Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. Proceedings of The National Academy of Sciences of The United States of America  vol. 117, (17) 9148-9150. 10.1073/pnas.2004241117
Norling L, Cooper D, Law H, Wright R and Iqbal A (2020). A pro-resolving role for Galectin-1 in acute inflammation. Frontiers Media  Frontiers in Pharmacology  vol. 11, (274) 10.3389/fphar.2020.00274
Topping LM, Thomas BL, Rhys HI, Tremoleda JL, Foster M, Seed M, Voisin MB, Vinci C, Law HL, Perretti M, Norling LV, Azevedo HS and Nissim A (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. Frontiers Media  Frontiers in Immunology  vol. 11, 10.3389/fimmu.2020.00010
Padovan MG and Norling LV (2020). Pro-resolving lipid mediators in sepsis and critical illness. Ovid Technologies (Wolters Kluwer Health)  Current Opinion in Clinical Nutrition and Metabolic Care  1-1. 10.1097/mco.0000000000000633

2019

Oggero S, Austin-Williams S and Norling LV (2019). The contrasting role of extracellular vesicles in vascular inflammation and tissue repair. Frontiers Media  Frontiers in Pharmacology  vol. 10, 10.3389/fphar.2019.01479

2018

(2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. Ebiomedicine  vol. 29, 60-69. 10.1016/j.ebiom.2018.02.003

2017

Perretti M and Norling LV (2017). Actions of SPM in regulating host responses in arthritis. Molecular Aspects of Medicine  vol. 58, 57-64. 10.1016/j.mam.2017.04.005
Piovezan AP, Batisti AP, Benevides MLACS, Turnes BL, Martins DF, Kanis L, Duarte ECW, Cavalheiro AJ, Bueno PCP, Seed MP, Norling LV, Cooper D, Headland S, Souza PRPS and Perretti M (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. Journal of Ethnopharmacology  vol. 204, 179-188. 10.1016/j.jep.2017.03.059
(2017). Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. Annals of The Rheumatic Diseases  vol. 76, (3) 612-619. 10.1136/annrheumdis-2016-209424
Norling LV, Ly L and Dalli J (2017). Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care  vol. 20, (2) 145-152. 10.1097/MCO.0000000000000353
Perretti M, Cooper D, Dalli J and Norling LV (2017). Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol  vol. 13, (2) 87-99. 10.1038/nrrheum.2016.193
Souza PR, Jones HR and Norling LV (2017). Novel immunoregulatory mediators produced from omega-3 fatty acids. Nutrition, Immunity, and Infection  10.1201/9781315118901

2016

Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M and Serhan CN (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. American Association of Immunologists  Journal of Immunology  vol. 197, (6) 2362-2368. 10.4049/jimmunol.1502268
Souza PR and Norling LV (2016). Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. European Journal of Pharmacology  vol. 785, 165-173. 10.1016/j.ejphar.2015.05.072
Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN and Perretti M (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. Jci Insight  vol. 1, (5) 10.1172/jci.insight.85922

2015

(2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. Science Translational Medicine  vol. 7, (315) 10.1126/scitranslmed.aac5608
Canova DF, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB and Perretti M (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. Journal of Controlled Release  vol. 217, 284-292. 10.1016/j.jconrel.2015.09.021
Headland SE and Norling LV (2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology  vol. 27, (3) 149-160. 10.1016/j.smim.2015.03.014
Headland S, Norling L, Kim A, Jones H, Jan L and Perretti M (2015). Neutrophil-Derived Microvesicles Migrate into Cell-Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis. Faseb Journal  vol. 29,
Headland SE and Norling LV (2015). The resolution of inflammation: Principles and challenges. Seminars in Immunology  10.1016/j.smim.2015.03.014

2014

Burgmaier M, Schutters K, Willems B, Van der Vorst EPC, Kusters D, Chatrou M, Norling L, Biessen EAL, Cleutjens J, Perretti M, Schurgers LJ and Reutelingsperger CPM (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine  vol. 18, (10) 2117-2124. 10.1111/jcmm.12374
Montero-Melendez T, Madeira MFM, Norling LV, Alsam A, Curtis MA, da Silva TA and Perretti M (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3. Am J Pathol  vol. 184, (8) 2333-2341. 10.1016/j.ajpath.2014.04.009
Cash JL, Norling LV and Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today  vol. 19, (8) 1186-1192. 10.1016/j.drudis.2014.06.023
(2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep  vol. 4, 10.1038/srep05237
Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ and Perretti M (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. Embo Mol Med  vol. 6, (1) 27-42. 10.1002/emmm.201303503

2013

Norling LV and Dalli J (2013). Microparticles are novel effectors of immunity. Curr Opin Pharmacol  vol. 13, (4) 570-575. 10.1016/j.coph.2013.05.008
Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M and Perretti M (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics  vol. 12, (8) 2205-2219. 10.1074/mcp.M113.028589
Norling LV and Perretti M (2013). The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol  vol. 13, (3) 476-481. 10.1016/j.coph.2013.02.003
Norling LV and Perretti M (2013). Control of myeloid cell trafficking in resolution. J Innate Immun  vol. 5, (4) 367-376. 10.1159/000350612

2012

Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M and Cadavid A (2012). Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids  vol. 87, (4-5) 127-134. 10.1016/j.plefa.2012.08.003
Yazid S, Norling LV and Flower RJ (2012). Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system. Prostaglandins Other Lipid Mediat  vol. 98, (3-4) 94-100. 10.1016/j.prostaglandins.2011.11.005
Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol  vol. 32, (8) 1970-1978. 10.1161/ATVBAHA.112.249508

2011

Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. Journal of Immunology  vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865
Norling LV, Spite M, Yang R, Flower RJ, Perretti M and Serhan CN (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J Immunol  vol. 186, (10) 5543-5547. 10.4049/jimmunol.1003865

2010

Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med  vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D and Perretti M (2010). Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med  vol. 26, (6) 913-918. 10.3892/ijmm_00000542
Norling LV and Serhan CN (2010). Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med  vol. 268, (1) 15-24. 10.1111/j.1365-2796.2010.02235.x
Norling LV, Dalli J, Flower RJ, Serhan CN and Perretti M (2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. Faseb Journal  vol. 24,

2009

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M and Serhan CN (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature  vol. 461, (7268) 1287-U125. 10.1038/nature08541
Piqueras L, Sanz MJ, Perretti M, Morcillo E, Norling L, Mitchell JA, Li Y and Bishop-Bailey D (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukocyte Biol  vol. 86, (1) 115-122. 10.1189/JLB.0508284
Norling LV, Perretti M and Cooper D (2009). Endogenous galectins and the control of the host inflammatory response. J Endocrinol  vol. 201, (2) 169-184. 10.1677/JOE-08-0512

2008

Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY and Perretti M (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood  vol. 112, (6) 2512-2519. 10.1182/blood-2008-02-140533
Cooper D, Norling LV and Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukocyte Biol  vol. 83, (6) 1459-1466. 10.1189/jlb.1207831
Norling LV, Sampaio ALF, Cooper D and Perretti M (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. Faseb J  vol. 22, (3) 682-690. 10.1096/fj.07-9268com

2007

Harrington LS, Evans RJ, Wray J, Norling L, Swales KE, Vial C, Ali F, Carrier MJ and Mitchell JA (2007). Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATP. Mol Pharmacol  vol. 72, (5) 1132-1136. 10.1124/mol.107.037325

Grants

Grants of specific relevance to Predictive in vitro Models
Reprogramming Resolution in the Arthritic Joint
Norling L
£720,853 Versus Arthritis (01-09-2019 - 31-08-2024)
Joint protective actions of omega-3 derived lipid mediators
Norling L
£230,000 Barts Charity (01-04-2019 - 31-03-2022)


Investigating the role of omega-3 derived resolvins in inflammatory arthritis
Norling L
£334,897 Arthritis Research UK (01-05-2012 - 01-09-2018)
Abstract