Prof Gareth Ackland

Gareth Ackland

Clinical Professor of Perioperative Medicine

The William Harvey Research Institute
Queen Mary University of London
www.qmul.ac.uk/whri/people/academic-staff/items/acklandgareth.html

Research

myocardial injury, organ dysfunction after surgery, inflammation, sepsis, autonomic function

Interests

Ex vivo human studies- largely high-risk surgical patients.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity
Menuet C, Ben-Tal A, Linossier A, Allen AM, Machado BH, Moraes DJA, Farmer DGS, Paterson DJ et al.
Nature Reviews Cardiology, Springer Nature, 1-7.  
06-05-2025
Myocardial Injury After Major Head and Neck Surgery
Staibano P, Garg AX, Chan MTV, Polanczyk CA, Ackland GL, MacNeil SD, Patel A, Xie M et al.
Jama Otolaryngology - Head & Neck Surgery, American Medical Association (Ama) vol. 151 (7) 
24-04-2025
Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial
Ackland GL, Patel ABU, Miller S, del Arroyo AG, Thirugnanasambanthar J, Ravindran JI, Schroth J, Boot J et al.
European Heart Journal, Oxford University Press (Oup) vol. 46 (17), 1634-1644.  
19-02-2025
Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind, placebo-controlled randomised trial
Pinto BB, Shelley B, Dias P, Begum S, Ennahdi-Elidrissi F, Abbott TEF, Hewson R, Patel A et al.
Bja Open, Elsevier vol. 13 
19-02-2025
Handheld ultrasound versus palpation technique for radial artery cannulation in conscious patients before noncardiac surgery: an open-label randomised controlled study
Egan TC, Abbott TEF, Ackland GL, investigators FTACWU
British Journal of Anaesthesia, Elsevier vol. 134 (4), 1208-1210.  
07-02-2025
Corrigendum to ‘Effect of transauricular nerve stimulation on perioperative pain: a single-blind, analyser-masked, randomised controlled trial’ (Br J Anaesth 2023; 130: 458–76)
Patel ABU, Bibawy PPWM, Althonayan JIM, Majeed Z, Gan WL, Abbott TEF, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 134 (3) 
18-01-2025

2024

Preoperative activation of the renineangiotensin system and\nmyocardial injury in noncardiac surgery: exploratory mechanistic analysis of the SPACE randomised controlled trial
Gutierrez Del Arroyo A, ABBOTT T, Kapil V, Ackland G
British Journal of Anaesthesia, Elsevier 
19-12-2024
Chronic pain: a modifiable target to reduce perioperative cardiovascular morbidity
Sikandar S, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 134 (3), 627-631.  
12-12-2024
Perioperative myocardial injury
Hughes C, Ackland G, Shelley B
Bja Education, Elsevier vol. 24 (10), 352-360.  
01-08-2024
Adenosine signalling to astrocytes coordinates brain metabolism and function
Theparambil SM, Kopach O, Braga A, Nizari S, Hosford PS, Sagi-Kiss V, Hadjihambi A, Konstantinou C et al.
Nature, Springer Nature vol. 632 (8023), 139-146.  
03-07-2024
Early Intravenous Beta-Blockade with Esmolol in Adults with Severe Traumatic Brain Injury: A Phase 2a Intervention Design Study
Thomas M, Hayes K, White P, Baumer T, Beattie C, Ramesh A, Culliford L, Ackland GL et al.
Neurocritical Care, Springer Nature vol. 41 (3), 1009-1019.  
28-06-2024
High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response
Mi Y, Burnham KL, Charles PD, Heilig R, Vendrell I, Whalley J, Torrance HD, Antcliffe DB et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 16 (750) 
05-06-2024
The BJA Editorial Fellowship 2024: a barometer for the state of academic anaesthesiology, perioperative, pain, and critical care medicine
Vail EA, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 133 (1), 3-6.  
13-05-2024
Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction
Janssen H, Jhanji S, Oliver NS, Ackland GL, Investigators FTG, Korbonits M, Henson S, Yeung J et al.
British Journal of Anaesthesia, Elsevier vol. 132 (5), 843-848.  
05-03-2024
Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial
del Arroyo AG, Patel A, Abbott TEF, Begum S, Dias P, Somanath S, Middleditch A, Cleland S et al.
British Journal of Anaesthesia, Elsevier vol. 132 (5), 857-866.  
09-02-2024
Transcriptional response of the heart to vagus nerve stimulation
Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Gutierrez Del Arroyo A, Crescente M, Tinker A et al.
Physiological Genomics, American Physiological Society vol. 56 (2), 167-178.  
01-02-2024
Pathophysiological mechanisms underlying increased circulating cardiac troponin in noncardiac surgery: a narrative review
Bollen Pinto B, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 132 (4), 653-666.  
22-01-2024
Cystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study
Prowle JR, Croal B, Abbott TEF, Cuthbertson BH, Wijeysundera DN, Myles PS, Shulman MA, Wallace S et al.
Clinical Kidney Journal, Oxford University Press (Oup) vol. 17 (1), sfae004-sfae004.  
04-01-2024
Mortality and major postoperative complications within 1 year after vascular surgery: a prospective cohort study.
Polok K, Biccard BM, Chan MTV, Archbold RA, Wang CY, Sigamani A, Urrútia G, Cruz P et al.
Polish Archives of Internal Medicine, &Quot;Medycyna Praktyczna&Quot; Spolka Jawna vol. 134 (2) 
02-01-2024

2023

Transauricular nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: Protocol for a phase 2A, proof-of-concept, sham-controlled randomised trial
Ackland GL, Martin T, Joseph M, Dias P, Hameed R, del Arroyo AG, Hewson R, Abbott TEF et al.
Plos One, Public Library of Science (Plos) vol. 18 (12) 
22-12-2023
Transcriptional response of the heart to vagus nerve stimulation.
Kellett DO, Aziz Q, Humphries JD, Korsak A, Braga A, Del Arroyo AG, Crescente M, Tinker A et al.
Physiological Genomics vol. 56 (2), 167-178.  
04-12-2023
ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation
Lurati Buse G, Bollen Pinto B, Abelha F, Abbott TEF, Ackland G, Afshari A, De Hert S, Fellahi JL et al.
European Journal of Anaesthesiology vol. 40 (12), 888-927.  
01-12-2023
Discontinuation vs. continuation of renin–angiotensin system inhibition before non-cardiac surgery: the SPACE trial
Ackland G
European Heart Journal, Oxford University Press 
07-11-2023
Heart rate recovery after orthostatic challenge and cardiopulmonary exercise testing in older individuals: prospective multicentre observational cohort study
James A, Bruce D, Tetlow N, Patel ABU, Black E, Whitehead N, Ratcliff A, Humphreys AJ et al.
Bja Open, Elsevier vol. 8 
03-11-2023
One-year Outcomes after Discharge from Noncardiac Surgery and Association between Predischarge Complications and Death after Discharge: Analysis of the VISION Prospective Cohort Study
Roshanov PS, Chan MTV, Borges FK, Conen D, Wang CY, Xavier D, Berwanger O, Marcucci M et al.
Anesthesiology, Wolters Kluwer vol. 140 (1), 8-24.  
15-09-2023
Study protocol for IMPRoVE: a multicentre prospective observational cohort study of the incidence, impact and mechanisms of perioperative right ventricular dysfunction in non-cardiac surgery
Keast T, McErlane J, Kearns R, McKinlay S, Raju I, Watson M, Robertson KE, Berry C et al.
Bmj Open, Bmj vol. 13 (9) 
01-09-2023
Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training
Korsak A, Kellett DO, Aziz Q, Anderson C, D’Souza A, Tinker A, Ackland GL, Gourine AV
Cardiovascular Research, Oxford University Press (Oup) vol. 119 (13), 2329-2341.  
30-07-2023
Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release
Kopach O, Sylantyev S, Bard L, Michaluk P, Heller JP, del Arroyo AG, Ackland GL, Gourine AV et al.
Iscience, Elsevier vol. 26 (7) 
28-06-2023
Early Intravenous Beta-Blockade with Esmolol in Adults with Severe Traumatic Brain Injury (EBB-TBI): Protocol for a Phase 2a Intervention Design Study
Thomas M, Hayes K, White P, Ramesh A, Culliford L, Ackland G, Pickering A
Neurocritical Care, Springer Nature vol. 40 (2), 795-806.  
12-06-2023
Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery
Edwards MR, Forbes G, Walker N, Morton DG, Mythen MG, Murray D, Anderson I, Mihaylova B et al.
Trials, Springer Nature vol. 24 (1) 
06-05-2023
Effect of transauricular nerve stimulation on perioperative pain: a single-blind, analyser-masked, randomised controlled trial
Patel ABU, Bibawy PPWM, Althonayan JIM, Majeed Z, Gan WL, Abbott TEF, Ackland GL
British Journal of Anaesthesia, Elsevier 
22-02-2023

2022

Arterial cannulation with ultrasound: clinical trial protocol for a randomised controlled trial comparing handheld ultrasound versus palpation technique for radial artery cannulation
Lan-Pak-Kee V, Ackland GL, Egan TC, Abbott TE, Elsheikh F, Investigators TACWU, Barrett S, Gooneratne M et al.
Bja Open, Elsevier vol. 4 
01-12-2022
Statistical anaysis plan: VATS RCT.
Ackland G
 
28-06-2022
Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis
Walker SLM, Muthoo C, Sanchez J, Del Arroyo AG, Ackland GL
Intensive Care Medicine Experimental, Springer Nature vol. 10 (1) 
20-06-2022
Trans-auricular vagus nerve stimulation to reduce perioperative pain and morbidity: protocol for a single-blind analyser-masked randomised controlled trial
Patel ABU, Bibawy PPWM, Majeed Z, Gan WL, Ackland GL
Bja Open, Elsevier vol. 2 
01-06-2022
IL-1ra polymorphisms and risk of epidural-related maternal fever (EPIFEVER-2): study protocol for a multicentre, observational mechanistic cohort study
Ali A, Weber V, Thompson SJ, Abbott TEF, Harmston R, David AL, Ackland GL, investigators FTE
International Journal of Obstetric Anesthesia, Elsevier vol. 50 
18-03-2022
Hypotension as a marker or mediator of perioperative organ injury: a review
Ackland G, ABBOTT T
British Journal of Anaesthesia, Elsevier 
09-02-2022
Reply to: Monitors are not a treatment.
Abbott TEF, Ackland GL
Eur J Anaesthesiol vol. 39 (2), 180-180.  
01-02-2022
Metformin and mortality after surgery: a systematic review and meta-analysis
Jones TF, Iakovou D, Makariou N, Fowler AJ, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 128 (4), e277-e279.  
26-01-2022
2 The Inflammatory Response to Surgery
Ackland GL, Walker SLM, Jones TF
In Perioperative Medicine, Elsevier 9-15.  
01-01-2022

2021

Interleukin-1 receptor antagonist and risk of caesarean delivery after onset of labour: a Mendelian randomisation analysis.
Ackland G, Van Duijvenboden S, ABBOTT T, Gutierrez Del Arroyo A, Wilson M, David A
British Journal of Anaesthesia, Elsevier 
18-11-2021
The potential for autonomic neuromodulation to reduce perioperative complications and pain: a systematic review and meta-analysis
Patel ABU, Weber V, Gourine AV, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 128 (1), 135-149.  
18-11-2021
Immunomodulation of innate immunity by brachial plexus blockade: a crossover study
May SM, Chiang E, Reyes A, Martir G, Patel A, Karmali S, Patel S, West S et al.
British Journal of Anaesthesia vol. 127 (3), e116-e118.  
17-11-2021
Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study
May SM, Chiang E, Reyes A, Martir G, Patel A, Karmali S, Patel S, West S et al.
Brain Behavior & Immunity - Health, Elsevier vol. 16 
15-07-2021
Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial
Heywood WE, Bliss E, Bahelil F, Cyrus T, Crescente M, Jones T, Iqbal S, Paredes LG et al.
British Journal of Anaesthesia, Elsevier vol. 127 (4), 511-520.  
06-07-2021
O10: METFORMIN TREATMENT IMPROVES LYMPHOCYTE METABOLISM IN A MOUSE MODEL OF MAJOR SURGERY
Jones T, Gutierrez A, Arroyo D, Henson S, Ackland G
 
27-04-2021
Preoperative lymphopaenia, mortality, and morbidity after elective surgery: systematic review and meta-analysis
Schroth J, Weber V, Jones TF, Del Arroyo AG, Henson SM, Ackland GL
British Journal of Anaesthesia, Elsevier 
29-03-2021
Preprints in perioperative medicine: immediacy for the greater good
Pearse RM, Ackland GL, Asai T, Hemmings HC
British Journal of Anaesthesia, Elsevier vol. 126 (5), 915-918.  
29-03-2021
International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)
Farmer AD, Strzelczyk A, Finisguerra A, Gourine AV, Gharabaghi A, Hasan A, Burger AM, Jaramillo AM et al.
Frontiers in Human Neuroscience, Frontiers vol. 14 
23-03-2021
Mode of blood pressure monitoring and morbidity after noncardiac surgery: A prospective multicentre observational cohort study
Abbott TEF, Howell S, Pearse RM, Ackland GL
European Journal of Anaesthesiology vol. 38 (5), 468-476.  
12-01-2021

2020

Reducing the dose of neuromuscular blocking agents with adjuncts: a systematic review and meta-analysis
Weber V, Abbott TEF, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 126 (3), 608-621.  
17-11-2020
Selective optogenetic stimulation of efferent fibers in the vagus nerve of a large mammal
Booth LC, Yao ST, Korsak A, Farmer DGS, Hood SG, McCormick D, Boesley Q, Connelly AA et al.
Brain Stimulation, Elsevier vol. 14 (1), 88-96.  
17-11-2020
Angiotensin converting enzyme inhibitors and angiotensin receptor blockers
Shrimpton AJ, Walker SLM, Ackland GL
Bja Education, Elsevier vol. 20 (11), 362-367.  
27-08-2020
MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study
May S, Abbott TEF, Gutierrez Del Arroyo A, Reyes A, Martir G, Stephens RCM, Brealey D, Cuthbertson B et al.
British Journal of Anaesthesia, Elsevier vol. 125 (5), 661-671.  
25-07-2020
MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: a prospective observational mechanistic cohort study
May SM, Abbott TEF, Del Arroyo AG, Reyes A, Martir G, Stephens RCM, Brealey D, Cuthbertson BH et al.
British Journal of Anaesthesia, Elsevier vol. 125 (5), 661-671.  
24-07-2020
A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study
Riedel B, Li MHG, Lee CHA, Ismail H, Cuthbertson BH, Wijeysundera DN, Ho KM, Wallace S et al.
British Journal of Anaesthesia 
18-07-2020
Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure
Machhada A, Hosford PS, Dyson A, Ackland GL, Mastitskaya S, Gourine AV
Jacc Basic to Translational Science 
01-07-2020
Prospective observational study of postoperative infection and outcomes after noncardiac surgery: analysis of prospective data from the VISION cohort
Wan YI, Patel A, ABBOTT TEF, Achary C, Macdonald N, Duceppe E, Sessler DI, Szczeklik W et al.
British Journal of Anaesthesia, Elsevier Bv 
30-05-2020
The effect of general anaesthetics on brain lactate release
Hadjihambi A, Karagiannis A, Theparambil SM, Ackland GL, Gourine AV
European Journal of Pharmacology, Elsevier vol. 881 
19-05-2020
Experimental medicine in anaesthesia-related research: UK and US activity
Patel ABU, Stevens J, Ackland GL
 
01-04-2020
Elevated heart rate after noncardiac surgery: post hoc analysis of a prospective observational cohort study
Patel ABU, May SM, Reyes A, Martir G, Abbott TEF, Brealey D, Stephens RCM, Ackland GL
 
01-04-2020
Sex influences cardiac dysfunction in early polymicrobial sepsis, independent of leucocyte-derived tumour necrosis factor-α
Walker SLM, Muthoo C, Sanchez J, Del Arroyo AG, Ackland GL
 
01-04-2020
Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study
Ackland GL, ABBOTT T, Jones TF, Leuwer M, Pearse R, Niebrzegowska E, Wragg A, Archbold A et al.
British Journal of Anaesthesia, Elsevier 
05-03-2020
Preoperative n-terminal pro-b-type natriuretic peptide and cardiovascular events after noncardiac surgery: A cohort study
Duceppe E, Patel A, Chan MTV, Berwanger O, Ackland G, Kavsak PA, Rodseth R, Biccard B et al.
Annals of Internal Medicine vol. 172 (2), 96-104.  
21-01-2020
40 What happens to the autonomic nervous system in critical illness?
Ackland GL
In Evidence-Based Practice of Critical Care, Elsevier 279-284.e1.  
01-01-2020

2019

Integration of the Duke Activity Status Index into Preoperative Risk Evaluation: A Multicentre Prospective Cohort Study
Wijeysundera D, Beattie WS, Hillis G, ABBOTT T, Shulman M, Ackland G, Mazer D, Myles P et al.
British Journal of Anaesthesia, Elsevier 
19-12-2019
Correction: Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies
Ackland GL, Abbott TEF, Minto G, Clark M, Owen T, Prabhu P, May SM, Reynolds JA et al.
Plos One, Public Library of Science (Plos) vol. 14 (12) 
05-12-2019
Inotropes and Vasopressors for Shock
Patel ABU, Ackland GL
Deckermed Critical Care of The Surgical Patient, Decker 
06-11-2019
Elevated heart rate after non-cardiac surgery: post-hoc analysis of a prospective observational cohort study
Patel ABU, May SM, Reyes A, Martir G, Brealey D, Stephens RCM, Abbott TEF, Ackland GL
, Cold Spring Harbor Laboratory 
02-11-2019
Salvaging remote ischaemic preconditioning as a therapy for perioperative acute kidney injury
Zarbock A, Kellum JA, Gourine AV, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 124 (1), 8-12.  
17-10-2019
Bupivacaine reduces release of interleukin-1 receptor antagonist from circulating neutrophils obtained from women in active labour
del Arroyo AG, Sanchez J, Reyes A, Ackland GL, Investigators E
 
01-10-2019
Serial proteomic characterisation of skin during the perioperative period
del Arroyo AG, Cyrus T, Bahelil F, Bliss E, Heywood W, Mills K, Ackland GL, group P-OS
 
01-10-2019
Orthostatic autonomic dysfunction is associated with postoperative morbidity in patients undergoing noncardiac surgery
Reynolds J, May SM, Reyes A, Martir G, Karmali S, Brealey D, Stephens R, Ackland GL
 
01-10-2019
P3509Leukocyte derived tumour necrosis factor modulates cardiac function in health and disease
Walker S, Del Arroyo AG, Sanchez J, Ackland GL
European Heart Journal, Oxford University Press (Oup) vol. 40 (Supplement_1) 
01-10-2019
Redefining the perioperative stress response: a narrative review
Manou-Stathopoulou V, Korbonits M, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 123 (5), 570-583.  
20-09-2019
Hospital-level evaluation of the effect of a national quality improvement programme: time-series analysis of registry data
Stephens TJ, Peden CJ, Haines R, Grocott MPW, Murray D, Cromwell D, Johnston C, Hare S et al.
Bmj Quality and Safety, Bmj Publishing Group 
12-09-2019
Acquired loss of cardiac vagal activity is associated with myocardial injury in patients undergoing noncardiac surgery: prospective observational mechanistic cohort study
May SM, Reyes A, Martir G, Reynolds J, Paredes LG, Karmali S, Stephens RCM, Brealey D et al.
British Journal of Anaesthesia, Elsevier vol. 123 (6), 758-767.  
03-09-2019
NMDA receptor modulation of glutamate release in activated neutrophils
del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, Nightingale TD, Lambden S et al.
Ebiomedicine, Elsevier Bv vol. 47, 457-469.  
01-09-2019
A national quality improvement programme to improve survival after emergency abdominal surgery: the EPOCH stepped-wedge cluster RCT
Peden CJ, Stephens T, Martin G, Kahan BC, Thomson A, Everingham K, Kocman D, Lourtie J et al.
Health and Social Care Delivery Research, National Institute For Health and Care Research vol. 7 (32), 1-96.  
01-09-2019
Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies
Ackland GL, Abbott TEF, Minto G, Clark M, Owen T, Prabhu P, May SM, Reynolds JA et al.
Plos One vol. 14 (8) 
01-08-2019
Association between complications and death within 30 days after noncardiac surgery.
The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators
Canadian Medical Association Journal, Joule Inc. vol. 191 (30), E830-E837.  
28-07-2019
Type 2 diabetes is associated with the accumulation of senescent T cells
Lau EYM, Carroll EC, Callender LA, Hood GA, Berryman V, Pattrick M, Finer S, Hitman GA et al.
Clinical & Experimental Immunology, Wiley 
28-06-2019
Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study
Bartoszko J, Thorpe KE, Laupacis A, Wijeysundera DN, Myles PS, Shulman MA, Wallace S, Farrington C et al.
British Journal of Anaesthesia 
19-06-2019
Electroencephalography-guided anaesthetic administration does not impact postoperative delirium among older adults undergoing major surgery: an independent discussion of the ENGAGES trial
Ackland GL, Pryor KO
British Journal of Anaesthesia, Elsevier vol. 123 (2), 112-117.  
10-05-2019
Chronotropic incompetence and myocardial injury after non-cardiac surgery: planned secondary analysis of a prospective observational international cohort study
ABBOTT TEF, PEARSE RM, beattie S, Phull M, Beilstein C, Raj A, Grocott M, Cuthbertson B et al.
Bja: British Journal of Anaesthesia, Elsevier vol. 123 (1), 17-26.  
04-05-2019
Serum microRNAs and perioperative myocardial injury
May SM, Abbott TEF, Del Arroyo AG, Cuthbertson BH, Wijeysundera DN, Pearse RM, Ackland GL
 
01-03-2019
Perioperative plasma cortisol levels and myocardial injury after non-cardiac surgery
Manou-Stathopoulou V, Abbott TEF, May SM, Cuthbertson BH, Wijeysundera DN, Pearse RM, Ackland GL
 
01-03-2019
Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery
Sessler DI, Bloomstone JA, Aronson S, Berry C, Gan TJ, Kellum JA, Plumb J, Mythen MG et al.
British Journal of Anaesthesia, Elsevier vol. 122 (5), 563-574.  
27-02-2019
Perioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicine
Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG, Lacey J, Pinsky MR, Grocott MP et al.
British Journal of Anaesthesia, Elsevier vol. 122 (5), 542-551.  
14-02-2019
Intra-operative heart rate and postoperative outcomes – rowing against the tide?
Pinto BB, Filipovic M, Ackland G
European Journal of Anaesthesiology, Wolters Kluwer vol. 36 (2), 90-92.  
01-02-2019
Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery
McEvoy MD, Gupta R, Koepke EJ, Feldheiser A, Michard F, Levett D, Thacker JKM, Hamilton M et al.
British Journal of Anaesthesia 
03-01-2019
Cardiac Vagus and Exercise.
Gourine AV, Ackland GL
Physiology (Bethesda) vol. 34 (1), 71-80.  
01-01-2019
Perioperative Quality Initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery
ACKLAND GL
British Journal of Anaesthesia, Elsevier 
01-01-2019
Leukocyte derived tumour necrosis factor modulates cardiac function in health and disease
Walker S, Del Arroyo AG, Sanchez J, Ackland GL
 
01-01-2019
Autonomic Dysfunction in Shock
Ackland GL
In Hemodynamic Monitoring, Springer Nature 71-80.  
01-01-2019

2018

Cardiac vagal dysfunction and myocardial injury\nafter non-cardiac surgery: a planned secondary\nanalysis of the measurement of Exercise Tolerance\nbefore surgery study
ABBOTT TEF, PEARSE RM, ACKLAND GL, Wijeysundera DN, Cuthbertson BH
Bja, Elsevier Ltd On Behalf of British Journal of Anaesthesia. vol. 122 (2), 188-197.  
17-12-2018
Role of leucocyte caspase-1 activity in epidural-related maternal fever: a single-centre, observational, mechanistic cohort study
del Arroyo AG, Sanchez J, Patel S, Phillips S, Reyes A, Cubillos C, Fernando R, David AL et al.
British Journal of Anaesthesia 
29-10-2018
Perioperative medicine and UK plc
Ackland GL, Galley HF, Shelley B, Lambert DG
British Journal of Anaesthesia 
26-10-2018
Preoperative systemic inflammation and perioperative myocardial injury: prospective observational multicentre cohort study of patients undergoing non-cardiac surgery
Ackland GL, Abbott TEF, Cain D, Edwards MR, Sultan P, Karmali SN, Fowler AJ, Whittle JR et al.
British Journal of Anaesthesia 
01-10-2018
Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery
TORRANCE H, LONGBOTTOM R, VIVIAN M, Lalabekyan B, ABBOTT TEF, ACKLAND GL, HINDS CJ, PEARSE RM et al.
Plos One, Public Library of Science (Plos) vol. 13 (9) 
13-09-2018
MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism?
Jones TF, Torrance HDT, Owen HC, Brohi K, Barnes MR, Knight JC, Hinds CJ, Ackland GL et al.
British Journal of Anaesthesia, Elsevier vol. 121 (2), e23-e24.  
01-08-2018
Clinical modulation of immunometabolism in sepsis
Turner S-J, Jones T, Sanchez J, Borgel J, Ackland GL
 
01-08-2018
Preoperative systemic inflammation and myocardial injury in non-cardiac surgery
Ackland GL, Abbott TF, Pearse RM, Investigators VEIN-CSPCE-U
 
01-08-2018
Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study
Wijeysundera D, PEARSE R, shulman M, ABBOTT TEF, Torres E, Ambosta A, Bernard C, Granton J et al.
Lancet, Elsevier vol. 391 (10140), 2631-2640.  
29-06-2018
Perioperative management of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers: a survey of perioperative medicine practitioners
WALKER S, ABBOTT TEF, Brown K, PEARSE R, ACKLAND G
Peerj, Peerj Inc. 
29-06-2018
Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost–consequence analysis
Lurati Buse G, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC et al.
Canadian Journal of Surgery vol. 61 (3), 185-194.  
01-06-2018
Caspase-1 and epidural-related maternal fever
Ackland G, del Arroyo AG, Sanchez J, Patel S, Phillips S, Reyes A, Sultan P, David A
 
01-05-2018
Contemporary perioperative management of ACE-inhibitors and angiotensin receptor blockers
Walker S, Abbott T, Brown K, Pearse R, Ackland G
 
01-05-2018
Serial holter recordings in non-cardiac surgery patients reveal postoperative autonomic impairment within 48 hours
May S, Karmali S, Reyes A, Paredes LG, Martir G, Stephens R, Brealey D, Ackland G
British Journal of Anaesthesia, Elsevier vol. 120 (5), e16-e17.  
01-05-2018

2017

A Prospective International Multicentre Cohort Study of Intraoperative Heart Rate and Systolic Blood Pressure and Myocardial Injury After Noncardiac Surgery: Results of the VISION Study
ABBOTT T, pearse RM, Archbold RA, Ahmad T, Niebrzegowska E, Wragg A, Rodseth R, Devereaux PJ et al.
Anesthesia and Analgesia, Lippincott, Williams & Wilkins vol. 126 (6), 1936-1945.  
26-10-2017
Autonomic regulation of systemic inflammation in humans: a multi-center, blinded observational cohort study.
ACKLAND GL, Minto G, Clark M, Whittle J, Stephens RCM, Owen T, Prabhu P, del Arroyo AG
Brain, Behavior, and Immunity, Elsevier 
11-08-2017
Heart rate variability in critical care medicine: a systematic review
Karmali SN, Sciusco A, May SM, Ackland GL
Intensive Care Medicine Experimental, Springer Nature vol. 5 (1) 
12-07-2017
Elevated preoperative heart rate is associated with cardiopulmonary and autonomic impairment in high-risk surgical patients.
ABBOTT T, Lee A, Pearse R, Ackland G, Minto G
British Journal of Anaesthesia, Oup vol. 119 (1), 87-94.  
28-06-2017
Vagal determinants of exercise capacity
Machhada A, Trapp S, Marina N, Stephens RCM, Whittle J, Lythgoe MF, Kasparov S, Ackland GL et al.
Nature Communications, Springer Nature vol. 8 (1) 
18-05-2017
Myocardial Injury After Noncardiac Surgery (MINS) in Vascular Surgical Patients: A Prospective Observational Cohort Study.
Biccard BM, Scott DJA, Chan MTV, Archbold A, Wang C-Y, Sigamani A, Urrútia G, Cruz P et al.
Ann Surg 
08-05-2017
Association of Postoperative High-Sensitivity Troponin Levels With Myocardial Injury and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery.
Writing Committee for the VISION Study Investigators, Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MTV, Srinathan SK, Walsh M et al.
Jama vol. 317 (16), 1642-1651.  
25-04-2017
Acute kidney injury and mortality 1 year after major non-cardiac surgery
O'Connor ME, Hewson RW, Kirwan CJ, Ackland GL, Pearse RM, Prowle JR
British Journal of Surgery, Wiley 
20-02-2017
Postoperative goal-directed therapy and development of acute kidney injury following major elective noncardiac surgery: post-hoc analysis of POM-O randomized controlled trial
Patel A, Prowle JR, Ackland GL, Investigators P-OS
Clinical Kidney Journal, Oxford University Press (Oup) vol. 10 (3), 348-356.  
12-01-2017
Reply: Glucagon-like peptide-1 mediates cardioprotection by remote ischaemic conditioning.
Basalay M, Mastitskaya S, Mrochek A, Ackland GL, Arroyo AGD, Sanchez J, Sjoquist P-O, Pernow J et al.
Cardiovasc Res vol. 113 (1), 13-14.  
09-01-2017

2016

Mechanisms of CO2/H+ Sensitivity of Astrocytes
Turovsky E, Theparambil SM, Kasymov V, Deitmer JW, del Arroyo AG, Ackland GL, Corneveaux JJ, Allen AN et al.
Journal of Neuroscience, Society For Neuroscience vol. 36 (42), 10750-10758.  
19-10-2016
Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning
Basalay MV, Mastitskaya S, Mrochek A, Ackland GL, del Arroyo AG, Sanchez J, Sjoquist P-O, Pernow J et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 112 (3), 669-676.  
04-10-2016
Baroreflex impairment and morbidity after major surgery
Toner A, Jenkins N, Ackland GL
British Journal of Anaesthesia, Oxford University Press (Oup): Policy B - Oxford Open Option B vol. 117 (3), 324-331.  
19-08-2016
Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness.
Ackland GL, Whittle J, Toner A, Machhada A, Del Arroyo AG, Sciuso A, Jenkins N, Dyson A et al.
Crit Care Med vol. 44 (8), e614-e624.  
01-08-2016
Preoperative heart rate and myocardial injury after non-cardiac surgery: results of a predefined secondary analysis of the VISION study
Abbott TEF, Ackland GL, Archbold RA, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E et al.
British Journal of Anaesthesia vol. 117 (2), 172-181.  
01-08-2016
Big Data: A Cheerleader for Translational Perioperative Medicine.
Ackland GL, Stephens RCM
Anesth Analg vol. 122 (6), 1744-1747.  
01-06-2016
Inflammation and Epidural-Related Maternal Fever
Sultan P, David AL, Fernando R, Ackland GL
Anesthesia & Analgesia vol. 122 (5), 1546-1553.  
01-05-2016
Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery.
Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Croal BL, Granton JT, Thorpe KE et al.
Bmj Open vol. 6 (3), e010359-e010359.  
11-03-2016
Subclinical cardiopulmonary dysfunction in stage 3 chronic kidney disease
Nelson A, Otto J, Whittle J, Stephens RCM, Martin DS, Prowle JR, Ackland GL
Open Heart, Bmj vol. 3 (1) 
01-02-2016
Astrocytes and Brain Hypoxia
Marina N, Kasymov V, Ackland GL, Kasparov S, Gourine AV
Advances in Experimental Medicine and Biology, Springer Nature vol. 903, 201-207.  
01-01-2016

2015

Non-inferiority of retrospective data collection for assessing perioperative morbidity
Patel ABU, Reyes A, Ackland GL
Peerj, Peerj vol. 3 
01-12-2015
Association of preoperative heart rate with postoperative myocardial injury
Abbott T, Ackland G, Wragg A, Archbold A, Devereaux P, Pearse R
 
01-12-2015
Association between intraoperative heart rate and postoperative myocardial injury in patients following non-cardiac surgery.
Abbott T, Ackland GL, Wragg A, Rodseth R, Archbold A, Pearse RM
Intensive Care Med Exp vol. 3 (Suppl 1), A751-A751.  
01-12-2015
Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve
Machhada A, Ang R, Ackland GL, Ninkina N, Buchman VL, Lythgoe MF, Trapp S, Tinker A et al.
Heart Rhythm, Elsevier Bv vol. 12 (11), 2285-2293.  
01-11-2015
Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis
Whittle J, Nelson A, Otto JM, Stephens RCM, Martin DS, Sneyd JR, Struthers R, Minto G et al.
Open Heart, Bmj vol. 2 (1) 
01-10-2015
Randomized controlled trial of vagal modulation by sham feeding in elective non-gastrointestinal (orthopaedic) surgery
Karmali S, Jenkins N, Sciusco A, John J, Haddad F, Ackland GL, Investigators P-XS
British Journal of Anaesthesia, Elsevier vol. 115 (5), 727-735.  
30-08-2015
Vagal Modulation of Atrial Fibrillation
Machhada A, Gourine AV, Ackland GL
Journal of The American College of Cardiology, Elsevier vol. 66 (8), 977-978.  
01-08-2015
Functional Oxygen Sensitivity of Astrocytes
Angelova PR, Kasymov V, Christie I, Sheikhbahaei S, Turovsky E, Marina N, Korsak A, Zwicker J et al.
Journal of Neuroscience, Society For Neuroscience vol. 35 (29), 10460-10473.  
22-07-2015
Metabolic dysfunction in lymphocytes promotes postoperative morbidity.
Edwards MR, Sultan P, del Arroyo AG, Whittle J, Karmali SN, Moonesinghe SR, Haddad FS, Mythen MG et al.
Clinical Science, Portland Press vol. 129 (5), 423-437.  
11-06-2015
Association between preoperative resting heart rate and postoperative myocardial injury in patients undergoing non-cardiac surgery
Abbott T, Rodseth R, Le Manach Y, Ackland G, Archbold A, Wragg A, Devereaux P, Pearse R
 
01-06-2015
Contemporary Perioperative Management of Adult Familial Dysautonomia (Riley-Day Syndrome)
Milne A, Mon WY, Down J, Obichere A, Ackland GL
A & a Case Reports, Wolters Kluwer vol. 4 (9), 111-113.  
01-05-2015
Individualised targeted haemodynamic therapy in high-risk surgical patients - authors' reply.
Ackland GL, Cecconi M, Pearse RM
The Lancet. Respiratory Medicine, Elsevier vol. 3 (4), e14-e15.  
01-04-2015
Presepsin: solving a soluble (CD14) problem in sepsis?
Ackland GL, Prowle JR
Intensive Care Medicine, Springer Nature vol. 41 (2), 351-353.  
22-01-2015
Man is the new mouse: Elective surgery as a key translational model for multi-organ dysfunction and sepsis
Cain DJ, del Arroyo AG, Ackland GL
Journal of The Intensive Care Society, Sage Publications vol. 16 (2), 154-163.  
07-01-2015
Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial
Ackland GL, Igbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al.
Lancet Respiratory Medicine vol. 3 (1), 33-41.  
01-01-2015
Heart Failure and Perioperative Care
Ackland GL
Asa Refresher Courses in Anesthesiology, Wolters Kluwer vol. 43 (1), 7-14.  
01-01-2015
Vagal modulation by sham feeding and post-operative gastrointestinal dysfunction following elective orthopaedic surgery
Karmali S, Jenkins N, Davies K, Reyes A, Edwards J, Kennedy J, Whittle J, Barnett S et al.
 
01-01-2015
Frailty and postoperative morbidity following elective orthopaedic surgery
Karmali S, Reyes A, Barnett S, Davies K, Moonesinghe R, John J, Haddad F, Ackland G
 
01-01-2015

2014

Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial
Ackland GL, Iqbal S, Paredes LG, Toner A, Lyness C, Jenkins N, Bodger P, Karmali S et al.
The Lancet Respiratory Medicine, Elsevier vol. 3 (1), 33-41.  
16-12-2014
Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning
Barsukevich V, Basalay M, Sanchez J, Mrochek A, Whittle J, Ackland GL, Gourine AV, Gourine A
Basic Research in Cardiology, Springer Nature vol. 110 (1) 
02-12-2014
Chronic kidney disease: a gateway for perioperative medicine
Ackland GL, Laing CM
British Journal of Anaesthesia, Elsevier vol. 113 (6), 902-905.  
10-07-2014
Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review
Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MPW, Ahern A et al.
Jama, American Medical Association (Ama) vol. 311 (21), 2181-2190.  
04-06-2014
Major gastrointestinal surgery is associated with a specific gene expression profile that is quantitatively associated with infectious complications
Fragkou P, Torrance H, Ackland G, Hinds C, Pearse R, O'Dwyer MJ
 
01-06-2014
Perioperative blood transfusion is associated with a characteristic immune response, excess infectious complications and death in patients undergoing scheduled major gastrointestinal surgery
Fragkou P, Prowle J, Ackland G, Hinds C, Pearse R, O'Dwyer MJ
 
01-06-2014
Myocardial Injury after Noncardiac Surgery
Botto F, Alonso-Coello P, Chan MTV, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P et al.
Anesthesiology, Wolters Kluwer vol. 120 (3), 564-578.  
01-03-2014
Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine
Cain DJ, del Arroyo AG, Ackland GL
Intensive Care Medicine Experimental, Springer Nature vol. 2 (1) 
27-02-2014
Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome
Henderson WR, Barnbrook J, Dominelli PB, Griesdale DE, Arndt T, Molgat-Seon Y, Foster G, Ackland GL et al.
Intensive Care Medicine Experimental, Springer Nature vol. 2 (1) 
26-02-2014
Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study
Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O'Dwyer MJ
Crit Care vol. 18 (5), 014-0541.  
01-01-2014
Cardiopulmonary Exercise Capacity and Preoperative Markers of Inflammation
Sultan P, Edwards MR, del Arroyo AG, Cain D, Sneyd JR, Struthers R, Minto G, Ackland GL
Mediators of Inflammation, Hindawi vol. 2014 (1) 
01-01-2014
The relationships between anesthesia, hemodynamics and outcome
Abbott T, Ackland GL
In Perioperative Hemodynamic Monitoring and Goal Directed Therapy, Cambridge University Press (Cup) 224-230.  
01-01-2014
A CNS cell group that controls electrical stability of the heart
Machhada A, Ang R, Ninkina N, Buchman VL, Ackland GL, Lythgoe MF, Marina N, Gourine AV
 
01-01-2014
Vagal mechanisms controlling exercise capacity
Machhada A, Gourine AV, Lythgoe MF, Ackland GL
 
01-01-2014

2013

Peripheral Neural Detection of Danger–Associated and Pathogen–Associated Molecular Patterns
Ackland GL, Kazymov V, Marina N, Singer M, Gourine AV
Critical Care Medicine, Wolters Kluwer vol. 41 (6), e85-e92.  
17-05-2013
Autonomic Dysfunction Is the Motor of Chronic Critical Illness
Toner A, Whittle J, Ackland GL
In Annual Update in Intensive Care and Emergency Medicine 2013, Springer Nature 199-209.  
01-01-2013

2012

Perioperative fluid therapy.
Pearse, Ackland
Praxis, Hogrefe Publishing Group vol. 101 (17), 1113-1118.  
01-08-2012
Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones
Mastitskaya S, Marina N, Gourine A, Gilbey MP, Spyer KM, Teschemacher AG, Kasparov S, Trapp S et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 95 (4), 487-494.  
27-06-2012
Remote ischaemic pre‐ and delayed postconditioning – similar degree of cardioprotection but distinct mechanisms
Basalay M, Barsukevich V, Mastitskaya S, Mrochek A, Pernow J, Sjöquist P, Ackland GL, Gourine AV et al.
Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, Wiley vol. 97 (8), 908-917.  
31-05-2012
Knowing the risk? NCEPOD 2011: a wake-up call for perioperative practice
Cain D, Ackland G
 
01-05-2012
Perioperative fluid therapy
Pearse RM, Ackland GL
The Bmj, Bmj vol. 344 (apr26 1) 
26-04-2012
Microvascular and macrovascular flow are uncoupled in early polymicrobial sepsis
Dyson A, Cone S, Singer M, Ackland GL
British Journal of Anaesthesia, Elsevier vol. 108 (6), 973-978.  
30-03-2012
In Response
Ackland GL
Anesthesia & Analgesia, Wolters Kluwer vol. 114 (3) 
01-03-2012
Preoperative muscle weakness as defined by handgrip strength and postoperative outcomes: a systematic review
Sultan P, Hamilton MA, Ackland GL
Bmc Anesthesiology, Springer Nature vol. 12 (1) 
17-01-2012

2011

Chronic Kidney Disease and Postoperative Morbidity After Elective Orthopedic Surgery
Ackland GL, Moran N, Cone S, Grocott MPW, Mythen MG
Survey of Anesthesiology, Wolters Kluwer vol. 55 (6), 287-288.  
01-12-2011
Chemical labelling of active serum thioester proteins for quantification
Holm L, Ackland GL, Edwards MR, Breckenridge RA, Sim RB, Offer J
Immunobiology, Elsevier vol. 217 (2), 256-264.  
23-07-2011
Reply from the authors
Ackland GL
British Journal of Anaesthesia, Elsevier vol. 106 (5) 
01-05-2011
Biomarkers to guide perioperative management
Edwards M, Whittle J, Ackland GL
Postgraduate Medical Journal, Oxford University Press (Oup) vol. 87 (1030), 542-549.  
17-01-2011
Morbidity following complex EVAR
Cross J, Edwards M, Harrison S, Richards T, Ackland G
International Journal of Surgery, Wolters Kluwer vol. 9 (7) 
01-01-2011

2010

Arterial Hyperoxia and In-Hospital Mortality After Resuscitation From Cardiac Arrest
Ackland GL, Dyson A, Singer M
Jama, American Medical Association (Ama) vol. 304 (13), 1440-1441.  
06-10-2010
Revised cardiac risk index and postoperative morbidity after elective orthopaedic surgery: a prospective cohort study
Ackland GL, Harris S, Ziabari Y, Grocott M, Mythen M, Investigators S
British Journal of Anaesthesia, Elsevier vol. 105 (6), 744-752.  
28-09-2010
Beta-adrenoreceptor modulation of metabolic, endocrine and immunologic function during critical illness.
Barnes SJ, Ackland GL
Endocrine Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers vol. 10 (3), 292-300.  
01-09-2010
Chronic Kidney Disease and Postoperative Morbidity After Elective Orthopedic Surgery
Ackland GL, Moran N, Cone S, Grocott MPW, Mythen MG
Anesthesia & Analgesia, Wolters Kluwer vol. 112 (6), 1375-1381.  
31-08-2010
Defining higher-risk surgery
Ackland GL, Edwards M
Current Opinion in Critical Care, Wolters Kluwer vol. 16 (4), 339-346.  
01-08-2010
Low-molecular-weight polyethylene glycol improves survival in experimental sepsis*
Ackland GL, Del Arroyo AG, Yao ST, Stephens RC, Dyson A, Klein NJ, Singer M, Gourine AV
Critical Care Medicine, Wolters Kluwer vol. 38 (2), 629-636.  
01-02-2010
Cardioprotection, attenuated systemic inflammation, and survival benefit of β1-adrenoceptor blockade in severe sepsis in rats*
Ackland GL, Yao ST, Rudiger A, Dyson A, Stidwill R, Poputnikov D, Singer M, Gourine AV
Critical Care Medicine, Wolters Kluwer vol. 38 (2), 388-394.  
01-02-2010
NEURO-IMMUNOMODULATION OF HUMAN CD14+CD16+NEUTROPHILS IN SEPSIS
del Arroyo AG, Singer M, Ackland GL
 
01-01-2010
DOBUTAMINE STRESS ECHOCARDIOGRAPHY UNMASKS MYOCARDIAL DYSFUNCTION IN EARLY RODENT POLYMICROBIAL SEPSIS
Barnes SJ, Singer M, Ackland GL
 
01-01-2010

2009

β1-Adrenoceptor distribution in the rat brain: An immunohistochemical study
Paschalis A, Churchill L, Marina N, Kasymov V, Gourine A, Ackland G
Neuroscience Letters, Elsevier vol. 458 (2), 84-88.  
15-04-2009
The Pivotal Role of Beta-adrenoreceptors in Critical Illness Pathophysiology
Ackland GL, Patterson AJ
In Intensive Care Medicine, Springer Nature 151-161.  
01-01-2009
Strain-specific and pathogen-specific physiologic and genomic differences in murine inflammatory cardiac dysfunction
Ackland G, Agrawal R, Hou C, Patterson A
Critical Care, Springer Nature vol. 13 (Suppl 1) 
01-01-2009

2008

False-Positive Presentation of Battle’s Sign During Hepatic Encephalopathy
Ackland GL, O’Beirne J, Platts AR, Ward SC
Neurocritical Care, Springer Nature vol. 9 (2) 
18-06-2008
Dehydration Induced by Bowel Preparation in Older Adults Does Not Result in Cognitive Dysfunction
Ackland GL, Harrington J, Downie P, Holding JW, Singh-Ranger D, Griva K, Mythen MG, Newman SP
Anesthesia & Analgesia, Wolters Kluwer vol. 106 (3), 924-929.  
01-03-2008

2007

Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing
Ackland GL, Kasymov V, Gourine AV
Biochemical Society Transactions, Portland Press vol. 35 (5), 1264-1268.  
25-10-2007
Pre‐operative high sensitivity C‐reactive protein and postoperative outcome in patients undergoing elective orthopaedic surgery
Ackland GL, Scollay JM, Parks RW, De Beaux I, Mythen MG
Anaesthesia, Wiley vol. 62 (9), 888-894.  
09-08-2007
Acute, Severe Hypoglycemia Occurring During General Anesthesia in a Nondiabetic Adult
Ackland GL, Smith M, McGlennan AP
Anesthesia & Analgesia, Wolters Kluwer vol. 105 (2), 553-554.  
01-08-2007
Novel biomarkers in critical care: utility or futility?
Ackland GL, Mythen MG
Critical Care, Springer Nature vol. 11 (6) 
01-01-2007

2006

Physiology of the Gastrointestinal Tract Including Splanchnic Blood Flow and Tonometry
Ackland G, Mythen M
In Gastrointestinal and Colorectal Anesthesia, Taylor & Francis 1-12.  
18-09-2006
Perioperative beta-blockade: beyond myocardial ischaemia
Ackland G
British Journal of Hospital Medicine, Mark Allen Group vol. 67 (5), 276-276.  
01-05-2006
Less Is Not More: A Lack of Evidence for Intraoperative Fluid Restriction Improving Outcome After Major Elective Gastrointestinal Surgery
Hamilton MA, Mythen MG, Ackland GL
Anesthesia & Analgesia, Wolters Kluwer vol. 102 (3), 970-971.  
01-03-2006
NEUROPHYSIOLOGY | Overview
Spyer KM, Ackland GL, Gourine AV
In Encyclopedia of Respiratory Medicine, Elsevier 131-138.  
01-01-2006
NEUROPHYSIOLOGY
Spyer KM, Ackland GL, Gourine AV
In Encyclopedia of Respiratory Medicine: Volume 1-4 
01-01-2006

2005

Low-dose Propofol Infusion for Controlling Acute Hyperspasticity after Withdrawal of Intrathecal Baclofen Therapy
Ackland GL, Fox R
Anesthesiology, Wolters Kluwer vol. 103 (3), 663-665.  
01-09-2005
Negative Pressure Pulmonary Edema as an Unsuspected Imitator of Acute Lung Injury/ARDS
Ackland GL, Mythen MG
Chest Journal, Elsevier vol. 127 (5), 1867-1868.  
01-05-2005

2004

Assessment of preoperative fluid depletion using bioimpedance analysis
Ackland GL, Singh-Ranger D, Fox S, McClaskey B, Down JF, Farrar D, Sivaloganathan M, Mythen MG
British Journal of Anaesthesia, Elsevier vol. 92 (1), 134-136.  
01-01-2004

2003

Endotoxin impairs the hypoxic ventilatory response in anaesthetized adult rats
Ackland GL, Gourine AV, Spyer KM
 
01-01-2003

2002

Effect of low‐dose volatile anaesthetics on ventilation during acute hypoxia
Ackland G
Anaesthesia, Wiley vol. 57 (12), 1224-1226.  
18-11-2002

2001

Physical incompatibility between atracurium and intravenous diclofenac
Ackland G
Anaesthesia, Wiley vol. 56 (3), 294-294.  
01-03-2001

2000

Understanding gastrointestinal perfusion in critical care: so near, and yet so far
Ackland G, Grocott MP, Mythen MG
Critical Care, Springer Nature vol. 4 (5) 
01-01-2000

1997

Red nucleus inhibits breathing during hypoxia in neonates1Paper presented at the conference of Neural Control of Breathing: Molecular to Organismal Perspectives, Madison, WI, 21–25 July 1996.1
Ackland GL, Noble R, Hanson MA
Respiratory Physiology & Neurobiology, Elsevier vol. 110 (2-3), 251-260.  
01-11-1997

1996

Unilateral cooling in the region of locus coeruleus blocks the fall in respiratory output during hypoxia in anaesthetized neonatal sheep
Moore PJ, Ackland GL, Hanson MA
Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, Wiley vol. 81 (6), 983-994.  
01-11-1996
Red nucleus lesions abolish the biphasic respiratory response to isocapnic hypoxia in decerebrate young rabbits.
Waites BA, Ackland GL, Noble R, Hanson MA
The Journal of Physiology, Wiley vol. 495 (1), 217-225.  
15-08-1996

1995

MICROINJECTION OF L-GLUTAMATE IN THE RED NUCLEUS PRODUCES INHIBITION OF RESPIRATORY OUTPUT IN DECEREBRATE NEONATAL RABBITS
WAITES BA, ACKLAND GL, NOBLE R, HANSON MA
 
01-01-1995
BILATERAL LESIONS IN THE RED NUCLEUS ABOLISH THE BIPHASIC RESPIRATORY RESPONSE TO HYPOXIA IN DECEREBRATE NEWBORN RABBITS
ACKLAND GL, WAITES BA, NOBLE R, HANSON MA
 
01-01-1995

1994

Is the Ventilatory Decline Seen in Newborns during Hypoxaemia Centrally Mediated?
Ackland GL, Moore PJ, Hanson MA
Advances in Experimental Medicine and Biology, Springer Nature vol. 360, 345-348.  
01-01-1994

1993

Hypoxia inhibits the effect on breathing of transient chemoreceptor stimulation in anaesthetized newborn rabbits
Ackland GL, Moore PJ, Hanson MA
 
27-08-1993

1992

CLASSICAL AND QUANTUM SIMULATION OF THE SURFACE-PROPERTIES OF ALPHA-AL2O3 - DISCUSSION
THOMAS JM, MACKRODT WC, ACKLAND G
 
01-01-1992

Association between preoperative pulse pressure and perioperative myocardial injury: an international observational cohort study of patients undergoing non-cardiac surgery.
Abbott T, Pearse RM, Archbold A, Wragg A, Kam E, Ahmad T, Khan AW, Niebrzegowska E et al.
British Journal of Anaesthesia, Oxford University Press (Oup) 
Pulse pressure and postoperative morbidity in high-risk surgical patients.
ACKLAND GL, Abbott TE, Pearse RM, Karmali SN, Whittle J, POM-HR Study Investigators
British Journal of Anaesthesia, Oxford University Press (Oup) 
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery: A stepped-wedge cluster randomised trial
PEARSE RM, Peden C, STEPHENS T, MARTIN G, KAHAN B, Thomson A, Rivett K, Wells D et al.
Lancet, Elsevier 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconBJA Centenary Award 2023 investigator award
Henrike Johanna Janssen and Gareth Ackland
£299,993 British Journal of Anaesthesia
02-09-2024 - 01-09-2027
bullet iconSurgical Epidemiology Platform trial feasibility project
Thomas Abbott, Gareth Ackland and Rupert Pearse
£205,755 Barts and the London Charity
01-05-2023 - 30-04-2026
bullet iconGareth Ackland - NIHR advanced fellowship (FUNNY)
Gareth Ackland
£1,138,183 NIHR National Institute for Health Research
01-06-2020 - 31-12-2025

bullet iconA national perioperative platform trial to promote diversity in perioperative research
Thomas Abbott, Rupert Pearse and Gareth Ackland
£29,625 Academy of Medical Sciences
01-09-2023 - 31-12-2024
bullet iconGlucoVITAL- Efficacy and Mechanism Evaluation Programme
Gareth Ackland and Sian Henson
£327,239 NIHR National Institute for Health Research
01-06-2023 - 31-05-2025
bullet iconINNOVATE UK- AFFERENT TVNS
Gareth Ackland
£101,858 Innovate UK
14-03-2022 - 31-12-2023
bullet iconEPIFEVER - personalised genomic medicine to guide labour analgesia
Gareth Ackland
£59,782 Obstetric Anaesthesia Association
01-03-2020 - 31-12-2023
bullet iconCardic Vagus and Exercise in Health Disease
Gareth Ackland and Andrew Tinker
£429,815 BHF British Heart Foundation
01-12-2019 - 30-06-2025
bullet iconCharacterisation of metabolic dysfunction during lymphopenia
Sian Henson and Gareth Ackland
£98,081 Royal College of Anaesthetists, The
01-10-2019 - 31-01-2023
bullet iconBrainstem vagal dysfunction after critical illness
Gareth Ackland
£3,978 Barts and the London Charity
01-09-2019 - 31-08-2022
bullet iconEsmolol in TBI - NIHR bid - North Bristol Trust led
Gareth Ackland
£12,462 NIHR National Institute for Health Research
01-07-2019 - 01-04-2023
bullet iconBiomarker-based identification of Nosocomial Infectious Complications following major abdominal surgery
Gareth Ackland
WHRF William Harvey Research Foundation
01-01-2019 - 31-12-2021
bullet iconPerioperative neuroendocrine control in high-risk surgical patients
Gareth Ackland
£4,000 Barts and the London Charity
01-09-2017 - 31-08-2018
bullet iconPost traumatic immune suppression: exploring mechanisms and developing a treatment strategy for patients with adverse long term outcomes
Gareth Ackland
£98,084 Barts and the London Charity
01-06-2016 - 30-06-2021
bullet iconPreventing postoperative infections through exercise induced mitophagy
Gareth Ackland
£90,327 British Journal of Anaesthesia
01-05-2016 - 30-04-2019
bullet iconThe British Oxygen Company Chair of Anaesthesia
Gareth Ackland
£240,000 Royal College of Anaesthetists, The
01-04-2016 - 31-03-2021