Dr Claire Villette

Claire Villette

Lecturer in Computational Bioengineering

Queen Mary University of London
www.seresearch.qmul.ac.uk/bioengineering/people/cvillette
ORCID

Research

Bone, Metastasis, Mechanobiology, Immune infiltration

Cancer Models, Infectious Disease and Inflammation Models, Musculoskeletal Models

Interests

With the B-MECA lab, I focus on the interactions between cancerous metastases and bone intrinsic remodelling processes, with a particular interest in dormancy and the influence of mechanical loading. I use both in silico and in vitro approaches, harnessing the synergy between mechanistic computational modelling and experimental tissue engineering.
https://www.thebmecalab.com/

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Development of an In Vitro Bone Metastasis Model Mimicking Cellular Crosstalk in the Bone Microenvironment
Villette C, Champion A
Congress of the European Society Of Biomaterials Turin 7 Sep 2025 - 11 Sep 2025. 
07-09-2025
Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema
Gucciardo F, Lebeau A, Pirson S, Buntinx F, Ivanova E, Blacher S, Brouillard P, Deroye J et al.
Circulation, Wolters Kluwer vol. 151 (19), 1412-1429.  
04-03-2025
Semi-mechanistic efficacy model for PARP + ATR inhibitors—application to rucaparib and talazoparib in combination with gartisertib in breast cancer PDXs
Villette CC, Dupuy N, Brightman FA, Zimmermann A, Lignet F, Zenke FT, Terranova N, Bolleddula J et al.
British Journal of Cancer, Springer Nature vol. 132 (5), 481-491.  
28-01-2025

2024

Influence of a change in activity regime on femoral bone architecture and failure behaviour
Villette C, Phillips ATM
Plos One, Public Library of Science (Plos) 
29-04-2024

2023

Should personalised dosing have a role in cancer treatment?
Villette CC, Orrell D, Millen J, Chassagnole C
Frontiers in Oncology, Frontiers vol. 13 
05-05-2023
Therapeutic effect of mechanical loading on bone metastasis: an hca modelling framework
Villette C, Geris L
 
01-01-2023

2022

Hybrid cellular automaton representation of the influence of mechanical stimulation on the development of bone metastases
Villette C, Geris L
 
10-10-2022

2021

A precision dosing application for patients treated with docetaxel and G-CSF.
Hurry C, Villette C, Mistry H, Millen J, Chassagnole C
 
01-07-2021
A precision dosing application for prostate cancer patients treated with docetaxel and G-CSF.
Villette C, Hurry C, Mistry H, Millen J, Chassagnole C
 
20-05-2021

2020

Multitechnology Biofabrication: A New Approach for the Manufacturing of Functional Tissue Structures?
Castilho M, de Ruijter M, Beirne S, Villette CC, Ito K, Wallace GG, Malda J
Trends in Biotechnology, Elsevier vol. 38 (12), 1316-1328.  
25-05-2020

2019

Influence of femoral external shape on internal architecture and fracture risk
Villette CC, Zhang J, Phillips ATM
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 19 (4), 1251-1261.  
08-11-2019
Developing a head and neck cancer model to assess the effect of radiotherapy on tumour growth inhibition and regrowth
Ortega F, Orell D, Villette C, Mistry H, Brightman F, Millen J, Chassagnole C
 
01-01-2019
A precision dosing application for prostate cancer chemotherapy
Villette C, Mistry H, Ortega FG, Orrell D, Brightman FA, Millen J, Chassagnole C
 
01-01-2019

2018

Rate and age-dependent damage elasticity formulation for efficient hip fracture simulations
Villette CC, Phillips ATM
Medical Engineering & Physics, Iop Publishing vol. 61 (1), 1-12.  
08-09-2018
Optimised heterogeneous scaffolds for bone tissue engineering: towards tailored mechanical stimulation
Villette C
 
01-01-2018
Heterogeneous design optimisation of tissue engineering scaffolds: in-vitro assessment of a digital design framework
Villette CC, Castilho M, Malda J, Phillips A
 
01-01-2018
Computational design optimisation for local control over mechanical properties in heterogeneous scaffolds
Villette CC, Castilho M, Malda J, Phillips A
 
01-01-2018

2017

Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations
Villette CC, Phillips ATM
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 16 (6), 2077-2091.  
09-08-2017
Optimised heterogeneous scaffolds for bone tissue engineering: towards tailored bone mechanotransduction
Villette C, Castilho M, Malda J, Phillips A
 
01-01-2017
Optimisation of heterogeneous bone tissue engineering scaffolds: proof of concept for a digital design tool
Villette C, Castilho M, Malda J, Phillips A
 
01-01-2017

2016

Surrogate poroelastic microscale representation of bone remodelling to inform an ef?cient structural mesoscale bone adaptation model
Villette C, Phillips A
 
01-01-2016
Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations
Villette C, Phillips A
 
01-01-2016

2015

Informing phenomenological structural bone remodelling with a mechanistic poroelastic model
Villette CC, Phillips ATM
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 15 (1), 69-82.  
03-11-2015
Rate and age-dependent damage elasticity formulation for efficient hip fracture simulations
Villette C, Phillips A
 
01-01-2015
Frangible optimised lower limb surrogate for assessing injury caused by underbelly blast
Villette C, Zaharie D, Phillips A
 
01-01-2015
Femoral bone mesoscale structural architecture prediction using musculoskeletal and finite element modelling
Phillips ATM, Villette CC, Modenese L
International Biomechanics, Taylor & Francis vol. 2 (1), 43-61.  
01-01-2015

2014

Towards a patient-specific combined musculoskeletal and finite element model of bone structure
Villette C, Phillips A
 
01-01-2014
Combined predictive structural finite element and musculoskeletal modelling of bone structure for study of fracture under solid blast condition
Villette C, Phillips A
 
01-01-2014
Combined musculoskeletal and finite element predictive modelling of bone structure for study of solid blast injury
Villette C, Phillips A
 
01-01-2014
Combined musculoskeletal and finite element predictive modelling of bone structure and simple fracture analysis
Villette C, Phillips A, Modenese L
 
01-01-2014
Combined finite element and musculoskeletal predictive structural modelling of the femur: Potential mechanobiology applications
Villette C, Modenese L, Phillips A
 
01-01-2014

2013

The influence of extreme speeds on scapula kinematics and the importance of controlling the plane of elevation
Prinold JAI, Villette CC, Bull AMJ
Clinical Biomechanics, Elsevier vol. 28 (9-10), 973-980.  
17-10-2013
Combined Musculoskeletal and Finite Element Modelling of the Femur
Villette C, Thibon A, Modenese L, Phillips A
 
01-01-2013