Prof Cleo Bishop

Cleo Bishop

Professor of Senescence

Blizard Institute
Queen Mary University of London
ORCID LinkedIn X

Research

Breast Cancer, Kidney, Skin, Senescence, Ageing, p16

Cancer Models, Skin Models

Interests

Cleo’s is the Director of the QMUL Phenotypic Screening Facility, with >18 years experience in compound/genetic high-throughput screening using 2D/3D in vitro models.

Her research seeks to illuminate senescence mechanisms, understand how cells age, explore the interplay between healthy ageing and cellular rejuvenation, and target senescence for ageing and cancer therapy.

Ageing team: understand the fundamental mechanisms that senescence heterogeneity; uncover novel routes to cellular rejuvenation; explore how senescence underpins ageing phenotypes; and discover novel senostatics and senolytics for healthy ageing.

Cancer team: how cells sense early carcinogenic events; find mechanisms to selectively trigger senescence in breast cancer; identify new genetic targets for pro-senescence therapy; and discover novel senostatic and senolytic approaches for cancer therapy.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

SAMP-Score: A morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells
Wallis R, Hughes BK, Moore M, O’Sullivan EA, McIlvenna LC, Gammon L, Hope A, Bellany F et al.
In Cold Spring Harbor Laboratory 
12-06-2025
SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden
Hughes BK, Davis A, Milligan D, Wallis R, Mossa F, Philpott MP, Wainwright LJ, Gunn DA et al.
Genome Medicine, Springer Science and Business Media Llc vol. 17 (1) 
14-01-2025

2024

The paradox of senescent-marker positive cancer cells: challenges and opportunities
O’Sullivan EA, Wallis R, Mossa F, Bishop CL
Npj Aging, Springer Science and Business Media Llc vol. 10 (1) 
14-09-2024
The promise of machine learning approaches to capture cellular senescence heterogeneity
Duran I, Bishop CL, Gil J, Wallis R
Nature Aging, Springer Science and Business Media Llc vol. 4 (9), 1167-1170.  
26-08-2024
Guidelines for minimal information on cellular senescence experimentation in vivo
Ogrodnik M, Carlos Acosta J, Adams PD, d’Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M et al.
Cell, Elsevier Bv vol. 187 (16), 4150-4175.  
01-08-2024
An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo
Lujan C, Tyler EJ, Ecker S, Webster AP, Stead ER, Martinez-Miguel VE, Milligan D, Garbe JC et al.
Genome Medicine, Springer Science and Business Media Llc vol. 16 (1) 
02-07-2024
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al.
Embo Reports, Springer Nature vol. 25 (9), 3842-3869.  
25-06-2024
Author Correction: The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans
Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK et al.
Genome Biology, Springer Science and Business Media Llc vol. 25 (1) 
10-06-2024

2023

SenPred: A single-cell RNA sequencing-based machine learning pipeline to classify senescent cells for the detection of an in vivo senescent cell burden
Bishop C, Hughes B, Davis A, Milligan D, Wallis R, Philpott M, Wainwright L, Gunn D
In Research Square Platform Llc 
17-11-2023
SenPred: A single-cell RNA sequencing-based machine learning pipeline to classify senescent cells for the detection of anin vivosenescent cell burden
Hughes BK, Davis A, Milligan D, Wallis R, Philpott MP, Wainwright LJ, Gunn DA, Bishop CL
In Cold Spring Harbor Laboratory 
23-10-2023
Death-seq and ye shall find: A novel screening strategy for dying cells
Wallis R, Bishop CL
Cell Metabolism, Elsevier Bv vol. 35 (10), 1675-1676.  
01-10-2023
P33 Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin models
Gorkic M, Messenger D, Wainwright L, Connelly J, Bishop CL
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e27-e27.  
07-07-2023
1454 Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin models
Gorkic M, Messenger D, Wainwright L, Connelly J, Bishop C
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (5), S249-S249.  
01-05-2023
Yearning for machine learning: applications for the classification and characterisation of senescence
Hughes BK, Wallis R, Bishop CL
Cell and Tissue Research, Springer Science and Business Media Llc vol. 394 (1), 1-16.  
05-04-2023
Investigating the utility and exploring biological targets of micro-wound healing compounds in 2D and 3D skin models
Gorkic M, Messenger D, Wainwright L, Connelly J, Bishop C
 
01-01-2023

2022

Current Understanding of the Role of Senescent Melanocytes in Skin Ageing
Hughes BK, Bishop CL
Biomedicines, Mdpi Ag vol. 10 (12), 3111-3111.  
02-12-2022
Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence
Wallis R, Milligan D, Hughes B, Mizen H, López-Domínguez JA, Eduputa U, Tyler EJ, Serrano M et al.
Aging, Impact Journals, Llc vol. 14 (10), 4220-4246.  
16-05-2022

2021

Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function
Palmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S et al.
Frontiers in Neuroscience, Frontiers Media Sa vol. 15 
07-10-2021
Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M et al.
Immunity, Elsevier vol. 54 (7), 1494-1510.e7.  
24-05-2021
Early growth response 2 (EGR2) is a novel regulator of the senescence programme
Tyler EJ, Gutierrez del Arroyo A, Hughes BK, Wallis R, Garbe JC, Stampfer MR, Koh J, Lowe R et al.
Aging Cell, Wiley vol. 20 (3) 
06-02-2021
Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype
Wallis R, Josipovic N, Mizen H, Robles‐Tenorio A, Tyler EJ, Papantonis A, Bishop CL
Journal of Extracellular Vesicles, Wiley vol. 10 (4) 
01-02-2021

2020

Early growth response 2 (EGR2) is a novel regulator of the senescence program
Tyler EJ, del Arroyo AG, Wallis R, Hughes B, Garbe JC, Stampfer MR, Koh J, Lowe R et al.
In Cold Spring Harbor Laboratory 
01-10-2020
Tissue engineering to better understand senescence: Organotypics come of age
Milligan DA, Tyler EJ, Bishop CL
Mechanisms of Ageing and Development, Elsevier Bv vol. 190, 111261-111261.  
01-09-2020
The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype
Wallis R, Mizen H, Bishop CL
Mechanisms of Ageing and Development, Elsevier Bv vol. 189, 111263-111263.  
01-07-2020
A multidimensional systems biology analysis of cellular senescence in aging and disease
Avelar RA, Ortega JG, Tacutu R, Tyler EJ, Bennett D, Binetti P, Budovsky A, Chatsirisupachai K et al.
Genome Biology, Springer Science and Business Media Llc vol. 21 (1) 
07-04-2020

2019

A CellAgeClock for expedited discovery of anti-ageing compounds
Lujan C, Tyler EJ, Ecker S, Webster AP, Stead ER, Martinez Miguel VE, Milligan D, Garbe JC et al.
In Cold Spring Harbor Laboratory 
13-10-2019
Cellular Senescence: Defining a Path Forward
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M et al.
Cell, Elsevier Bv vol. 179 (4), 813-827.  
01-10-2019
A Multidimensional Systems Biology Analysis of Cellular Senescence in Ageing and Disease
Avelar RA, Ortega JG, Tacutu R, Tyler E, Bennett D, Binetti P, Budovsky A, Chatsirisupachai K et al.
In Cold Spring Harbor Laboratory 
23-08-2019
Cell Migration Dynamics: High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform (Adv. Biosys. 8/2019)
Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL, Connelly JT
Advanced Biosystems, Wiley vol. 3 (8) 
01-08-2019
High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform
Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL, Connelly JT
Advanced Biosystems, Wiley, 1900011-1900011.  
13-06-2019
P035 Pharmacological inhibition of the canonical WNT signalling pathway represents a potential novel therapy for fibrosis in Crohn’s disease
Lewis A, Nijhuis A, Berti G, Bishop CL, Feakins R, Lindsay JO, Silver A
 
25-01-2019

2018

Ribosomal stress-induced senescence as a novel pro-senescence strategy for p16 positive basal-like breast cancer
Moore M, Gammon L, Dreger S, Koh J, Garbe JC, Stampfer MR, Philpott M, Jones L et al.
In Cold Spring Harbor Laboratory 
14-11-2018
eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival
Bolland H, McIntyre A, Shams-Nateri A, Bishop C, Silver A
 
01-01-2018

2017

682 Development of a 3D living skin equivalent to explore the influence of senescence on the skin ageing phenotype
Milligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C
 
01-10-2017
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling
Thompson CL, Plant JCT, Wann AKT, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP et al.
European Cells and Materials, Forum Multimedia Publishing Llc vol. 34, 128-141.  
20-09-2017
Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance
Nijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Soga T et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 26 (8), 1552-1564.  
16-02-2017
MCL-1 is modulated in Crohn’s disease fibrosis by miR-29b via IL-6 and IL-8
Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO, Silver A
Cell and Tissue Research, Springer Science and Business Media Llc vol. 368 (2), 325-335.  
11-02-2017

2016

Low Stress Ion Conductance Microscopy of Sub-Cellular Stiffness
Clarke RW, Novak P, Zhukov A, Tyler EJ, Cano-Jaimez M, Drews A, Richards O, Volynski K et al.
Soft Matter, Royal Society of Chemistry (Rsc) vol. 12 (38), 7953-7958.  
01-01-2016

2015

The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans
Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK et al.
Genome Biology, Springer Science and Business Media Llc vol. 16 (1) 
17-09-2015
Low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohnʼs Disease Phenotype
Lewis A, Mehta S, Hanna LN, Rogalski LA, Jeffery R, Nijhuis A, Kumagai T, Biancheri P et al.
Inflammatory Bowel Diseases, Oxford University Press (Oup) vol. 21 (8), 1926-1934.  
01-08-2015
Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration
Murray A, Letourneau A, Canzonetta C, Stathaki E, Gimelli S, Sloan-Bena F, Abrehart R, Goh P et al.
Stem Cells, Oxford University Press (Oup) vol. 33 (6), 2077-2084.  
21-05-2015
A siRNA screen to re-activate senescence in basal-like breast cancer
Moore M, Philpott M, Bishop C
Annals of Oncology, Elsevier Bv vol. 26, iii15-iii15.  
01-05-2015

2014

In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts
Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R et al.
Clinical Science, Portland Press Ltd. vol. 127 (5), 341-350.  
15-05-2014

2013

Cellular senescence mediated by p16INK4A-coupled miRNA pathways
Overhoff MG, Garbe JC, Koh J, Stampfer MR, Beach DH, Bishop CL
Nucleic Acids Research, Oxford University Press (Oup) vol. 42 (3), 1606-1618.  
09-11-2013

2011

A whole genome screen for HIV restriction factors
Liu L, Oliveira NMM, Cheney KM, Pade C, Dreja H, Bergin A-MH, Borgdorff V, Beach DH et al.
Retrovirology, Springer Science and Business Media Llc vol. 8 (1) 
14-11-2011

2010

Primary Cilium-Dependent and -Independent Hedgehog Signaling Inhibits p16(INK4A)
Bishop CL, Bergin AMH, Fessart D, Borgdorff V, Hatzimasoura E, Garbe JC, Stampfer MR, Koh J et al.
Mol Cell vol. 40 (4), 533-547.  
24-11-2010
Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1)
Borgdorff V, Lleonart ME, Bishop CL, Fessart D, Bergin AH, Overhoff MG, Beach DH
Oncogene vol. 29 (15), 2262-2271.  
01-04-2010

2007

The PsbZ subunit of Photosystem II in Synechocystis sp. PCC 6803 modulates electron flow through the photosynthetic electron transfer chain
Bishop CL, Ulas S, Baena-Gonzalez E, Aro E-M, Purton S, Nugent JHA, Mäenpää P
Photosynthesis Research, Springer Science and Business Media Llc vol. 93 (1-3), 139-147.  
22-05-2007

2006

Role for Centromeric Heterochromatin and PML Nuclear Bodies in the Cellular Response to Foreign DNA

Molecular and Cellular Biology, Informa Uk Limited vol. 26 (10), 3997-3997.  
01-05-2006
Role for centromeric heterochrornatin and PML nuclear bodies in the cellular response to foreign DNA
Bishop CL, Ramalho M, Nadkarni N, Kong WM, Higgins CF, Krauzewicz N
Mol Cell Biol vol. 26 (7), 2583-2594.  
01-04-2006

2004

PML nuclear bodies: A site for HDAC repression of VLP mediated gene expression?
Ramalho M, Bishop C, Higgins CF, Krauzewicz J
 
01-01-2004

2003

Molecular analysis of the Chlamydomonas nuclear gene encoding PsbW and demonstration that PsbW is a subunit of photosystem II, but not photosystem I
Bishop CL, Purton S, Nugent JHA
Plant Molecular Biology, Springer Science and Business Media Llc vol. 52 (2), 285-289.  
01-05-2003
Virus-like particles as a model for studying gene delivery
Ramalho M, Bishop CL, Higgins CF, Krauzewicz N
 
01-01-2003
Understanding transcriptional regulation of exogenously delivered DNA
Bishop CL, Ramalho M, McBride AA, Higgins CF, Krauzewicz N
 
01-01-2003

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconPOC: Senescence in the initiation and progression of prostate cancer in men of African descent
Cleo Bishop and Prabhakar Rajan
£73,420 Barts and the London Charity
18-06-2025 - 31-03-2026
solid heart iconDevelopment of an Organ-on-a-chip model of polycystic kidney disease using CRISPR modified human kidney cell line
Martin Knight and Cleo Bishop
£39,986 Kidney Research UK 
Grant Summary

01-12-2023 - 30-11-2025
solid heart iconEpithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme 
Grant Summary

01-12-2023 - 30-11-2027
solid heart iconBiophysical regulation of nucleolar structure and function in senescent cells and ageing
John Connelly and Cleo Bishop
£554,319 BBSRC Biotechnology and Biological Sciences Research Council
15-05-2023 - 14-05-2026
solid heart iconMulti-User Equipment Grant,‘Cell DIVE Imager for automated, single cell, multiplexed immunofluorescence microscopy
Cleo Bishop
£340,339 Wellcome Trust
01-01-2022 - 31-12-2026
solid heart iconInvestigating the utility and exploring biological targets of enhanced wound healing compounds in 2D
Cleo Bishop and John Connelly
£118,835 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2021 - 30-09-2025
solid heart iconInvestigating the utility and exploring biological targets of enhanced wound healing compounds in 2D
Cleo Bishop and John Connelly
£76,000 Unilever UK Ltd
01-10-2021 - 30-09-2025


bullet iconUnilever Cell DIVE Skin 3 makers
Cleo Bishop
£36,820 Unilever UK Ltd
01-11-2024 - 31-05-2025
bullet iconUnilever Cell Dive Lab services Bishop Lab
Cleo Bishop
£26,795 Unilever UK Ltd
21-08-2023 - 30-04-2024
bullet iconSenescent exosomers in skin ageing
Cleo Bishop
£72,000 Unilever UK Ltd
01-05-2022 - 30-04-2023
bullet iconSenolytic compound screening
Cleo Bishop
£105,001 Unilever UK Ltd
07-06-2021 - 14-07-2023
solid heart iconInvestigating the consequences of primary and paracrine driven secondary senescence for melanocyte function in 2D and 3D living skin equivalents - CASE STUDENTSHIP
Cleo Bishop and Michael Philpott
£114,126 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2020 - 30-09-2024
solid heart iconInvestigating the consequences of primary and paracrine-driven secondary senescence in melanocyte
Cleo Bishop and Michael Philpott
£82,000 Unilever UK Ltd
01-10-2020 - 30-09-2024
bullet iconCiTI-Pro-senescence therapies for basal-like breast cancer: A novel therapeutic innovation
Cleo Bishop, Oliver Pearce and John Connelly
£242,221 Barts and the London Charity
01-07-2020 - 31-05-2024
bullet iconUnderstanding the mechanobiology of senescence and ageing
John Connelly and Cleo Bishop
£134,519 DMT Dunhill Medical Trust, The
15-04-2019 - 15-06-2021
bullet iconTargeting senescence-specific apoptosis resistance genes for the clearance of senescent cells in 2D and 3D human models
Cleo Bishop
£178,534 BBSRC Biotechnology and Biological Sciences Research Council
19-07-2017 - 31-12-2019
bullet iconTargeting senescence-specific apoptosis resistance for the clearence of senescent cells in 2D and 3D human models
Cleo Bishop
£219,622 Unilever UK Ltd
01-01-2017 - 31-12-2019
bullet iconHigh throughput automated confocal imaging systems
Cleo Bishop
£307,272 Barts and the London Charity
01-11-2016 - 31-10-2019
bullet iconWilloughby studentships 2016
Cleo Bishop
£114,854 Willoughby Trustees
01-10-2016 - 31-12-2020
bullet iconReversing senescence in 3D tissue models of in vitro ageing
Cleo Bishop
£103,042 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2015 - 30-09-2019
bullet iconReversing senescence in 3D tissue models of in vitro agreeing
Cleo Bishop
£68,000 Unilever UK Ltd
01-10-2015 - 29-02-2020
bullet iconDTP 2013
Cleo Bishop
£45,650 MRC Medical Research Council
01-10-2013 - 30-09-2018