Dr Tom Nightingale
DPhilSenior Lecturer
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Intracellular Trafficking, Endothelial cells, Haemostasis, Inflammation, Weibel Palade Bodies, Cell Junctions
Interests
My interests are in vitro models of the vasculature. We hope to use these to closer investigate the intracellular trafficking events associated with inflammation and blood clotting. Upon endothelial stimulation clotting factors and inflammatory receptors are mobilised from intracellular stores. These are essential for recruiting platelets and leukocytes to sites of injury. We are also interested in understanding how junctions remodel to allow increased permeability and leukocyte transmigration. The vasculature is composed of a number of different cell types and is constantly exposed to flow. This is difficult to model using standard culture models.Publications
2025

El-Mansi S, Deegan KM, Donker L, Godinho S, Nightingale TD
In Cold Spring Harbor Laboratory
07-05-2025

Mobayen G, El-Mansi S, Chion A, Nightingale TD, McKinnon TAJ
Research and Practice in Thrombosis and Haemostasis, Elsevier Bv vol. 9 (4), 102922-102922.
01-05-2025
2024

El-Mansi S, Mitchell TP, Mobayen G, McKinnon TAJ, Miklavc P, Frick M, Nightingale TD
Blood Advances, American Society of Hematology vol. 8 (17), 4714-4726.
10-09-2024

Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al.
Embo Reports, Springer Nature vol. 25 (9), 3842-3869.
25-06-2024
2023

El-Mansi S, Mitchell TP, Miklavc P, Frick M, Nightingale TD
In Cold Spring Harbor Laboratory
12-08-2023

Bosseboeuf E, Chikh A, Chaker AB, Mitchell TP, Vignaraja D, Rajendrakumar R, Khambata RS, Nightingale TD et al.
Science Signaling, American Association For The Advancement of Science (Aaas) vol. 16 (786)
23-05-2023

El-Mansi S, Robinson CL, Kostelnik KB, McCormack JJ, Mitchell TP, Lobato-Márquez D, Rajeeve V, Cutillas P et al.
Blood, American Society of Hematology vol. 141 (8), 930-944.
23-02-2023
2022

Carpintero-Fernández P, Borghesan M, Eleftheriadou O, Pan-Castillo B, Fafián-Labora JA, Mitchell TP, Yuste A, Ogrunc M et al.
Cell Death &Amp; Disease, Springer Science and Business Media Llc vol. 13 (2)
19-02-2022
2021

Carpintero-Fernández P, Borghesan M, Eleftheriadou O, Fafián-Labora JA, Mitchell TP, Nightingale TD, Mayán MD, O’Loghlen A
In Cold Spring Harbor Laboratory
30-11-2021

Nollet M, Agrotis A, Michailidis F, Dokal AD, Rajeeve V, Burden J, Nightingale TD, Cutillas P et al.
In Cold Spring Harbor Laboratory
09-10-2021

Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al.
Immunity, Elsevier Bv vol. 54 (9), 1989-2004.e9.
01-09-2021

El-Mansi S, Nightingale TD
The International Journal of Biochemistry &Amp; Cell Biology, Elsevier Bv vol. 131, 105900-105900.
01-02-2021
2020

Mitchell TP, Kostelnik KB, Barker A, Schultz C, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S et al.
01-01-2020
2019

Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S et al.
Plos Biology, Public Library of Science (Plos) vol. 17 (12)
02-12-2019

del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, Nightingale TD, Lambden S et al.
Ebiomedicine, Elsevier Bv vol. 47, 457-469.
01-09-2019

Kostelnik KB, Barker A, Schultz C, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S, Cutillas P et al.
In Cold Spring Harbor Laboratory
02-05-2019
2018

Nightingale TD, McCormack JJ, Grimes W, Robinson C, Lopes da Silva M, White IJ, Vaughan A, Cramer LP et al.
Journal of Thrombosis and Haemostasis, Elsevier Bv vol. 16 (9), 1873-1886.
01-09-2018

Tarvala U, El Matary R, Nightingale T, Poston R
01-08-2018

Robinson CL, McCormack JJ, White IJ, Cutler DF, Nightingale TD
01-01-2018
2017

Stevenson NL, White IJ, McCormack JJ, Robinson C, Cutler DF, Nightingale TD
Journal of Cell Science, The Company of Biologists vol. 130 (15), 2591-2605.
01-08-2017
2016

Reglero N, Beal R, Cabrera C, Pickworth C, Golding M, Whiteford J, Nightingale T, Imhof B et al.
01-04-2016
2013

Nightingale T, Cutler D
Journal of Thrombosis and Haemostasis, Elsevier Bv vol. 11, 192-201.
01-06-2013
2012

Nightingale TD, Cutler DF, Cramer LP
Trends in Cell Biology, Elsevier Bv vol. 22 (6), 329-337.
01-06-2012
2011

Nightingale TD, White IJ, Doyle EL, Turmaine M, Harrison-Lavoie KJ, Webb KF, Cramer LP, Cutler DF
Journal of Cell Biology, Rockefeller University Press vol. 194 (4), 613-629.
15-08-2011

Rojo Pulido I, Nightingale TD, Darchen F, Seabra MC, Cutler DF, Gerke V
Traffic, Wiley vol. 12 (10), 1371-1382.
05-08-2011

Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF
Blood, American Society of Hematology vol. 117 (12), 3476-3476.
24-03-2011

MICHAUX G, DYER CEF, NIGHTINGALE TD, GALLAUD E, NURRISH S, CUTLER DF
Journal of Thrombosis and Haemostasis, Elsevier Bv vol. 9 (2), 392-401.
01-02-2011
2009

Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF
Blood, American Society of Hematology vol. 113 (20), 5010-5018.
14-05-2009

Nightingale TD, Frayne MEF, Clasper S, Banerji S, Jackson DG
J Biol Chem vol. 284 (6), 3935-3945.
06-02-2009
2008

Lui-Roberts WWY, Ferraro F, Nightingale TD, Cutler DF
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 19 (12), 5072-5081.
01-12-2008

Metcalf DJ, Nightingale TD, Zenner HL, Lui-Roberts WW, Cutler DF
Journal of Cell Science, The Company of Biologists vol. 121 (1), 19-27.
01-01-2008
2005

Nightingale TD, Banerji S, Jackson DG
01-01-2005
Grants

Tom Nightingale and Mathieu-Benoit Voisin
£286,032 BHF British Heart Foundation
01-02-2023 - 31-01-2026

James Whiteford and Tom Nightingale
£323,174 Barts and the London Charity
01-12-2022 - 30-09-2027

Ken Suzuki, Tom Nightingale, Mauro Perretti, Federica Marelli-Berg, Michael Barnes, Anthony Mathur and Fiona Lewis
£1,263,590 BHF British Heart Foundation
01-09-2020 - 31-05-2026

Tom Nightingale and James Whiteford
£233,773 Barts and the London Charity
01-09-2020 - 31-01-2024

Tom Nightingale
£232,656 BHF British Heart Foundation
01-02-2020 - 02-11-2023

Peter McCormick, Lesley Howell and Tom Nightingale
£107,727 Barts and the London Charity
01-10-2019 - 30-09-2023

Tom Nightingale
£200,752 BHF British Heart Foundation
18-04-2016 - 17-04-2019

Tom Nightingale
£389,244 MRC Medical Research Council
14-09-2015 - 13-10-2018