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Dr Tom Nightingale

Tom Nightingale
The William Harvey Research Institute
School of Medicine and Dentistry


Publications of specific relevance to Predictive in vitro Models


Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Benoit-Voisin M, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E and Nourshargh S (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Immunity  10.1016/j.immuni.2021.07.012
El-Mansi S and Nightingale TD (2021). Emerging mechanisms to modulate VWF release from endothelial cells. International Journal of Biochemistry and Cell Biology  vol. 131, 10.1016/j.biocel.2020.105900


del Arroyo AG, Hadjihambi A, Sanchez J, Turovsky E, Kasymov V, Cain D, Nightingale TD, Lambden S, Grant SGN, Gourine AV and Ackland GL (2019). NMDA receptor modulation of glutamate release in activated neutrophils. Elsevier Bv  Ebiomedicine  10.1016/j.ebiom.2019.08.004
Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S, Cutillas P and Nightingale TD (2019). Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration. Plos Biology  vol. 17, (12) 10.1371/journal.pbio.3000554


NIGHTINGALE TD, McCormack JJ, Grimes W, ROBINSON C, Lopes da Silva M, White IJ, Vaughan A, Cramer LP and Cutler DF (2018). Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade Bodies. Wiley  Journal of Thrombosis and Haemostasis  10.1111/jth.14218


NIGHTINGALE TD, CUTLER DF, Robinson C, McCormack JJ, White IJ and Stevenson NL (2017). Clathrin-mediated post-fusion membrane retrieval influences the exocytic mode of endothelial Weibel-Palade bodies., Editors: Schiavo G. Company of Biologists  Journal of Cell Science  10.1242/jcs.200840


Nightingale T and Cutler D (2013). The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story. Journal of Thrombosis and Haemostasis  vol. 11, (SUPPL.1) 192-201. 10.1111/jth.12225


Nightingale TD, Cutler DF and Cramer LP (2012). Actin coats and rings promote regulated exocytosis. Trends in Cell Biology  vol. 22, (6) 329-337. 10.1016/j.tcb.2012.03.003


Rojo Pulido I, Nightingale TD, Darchen F, Seabra MC, Cutler DF and Gerke V (2011). Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells. Traffic  vol. 12, (10) 1371-1382. 10.1111/j.1600-0854.2011.01248.x
Nightingale TD, Pattni K, Hume AN, Seabra MC and Cutler DF (2011). Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. (Blood (2009) 113, 20, (5010-5018)). Blood  vol. 117, (12) 10.1182/blood-2011-01-329136
NIGHTINGALE TD, White IJ, Doyle EL, Turmaine M, Harrison-Lavoie KJ, Webb KF, Cramer LP and Cutler DF (2011). Actomyosin II contractility expels von Willebrand factor from Weibel–Palade bodies during exocytosis. J Cell Biol.  vol. 194, (4) 613-629. 10.1083/jcb.201011119
Michaux G, Dyer CEF, Nightingale TD, Gallaud E, Nurrish S and Cutler DF (2011). A role for Rab10 in von Willebrand factor release discovered by an AP-1 interactor screen in C. elegans. Journal of Thrombosis and Haemostasis  vol. 9, (2) 392-401. 10.1111/j.1538-7836.2010.04138.x


Nightingale TD, Frayne MEF, Clasper S, Banerji S and Jackson DG (2009). A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium. Journal of Biological Chemistry  vol. 284, (6) 3935-3945. 10.1074/jbc.M805105200
NIGHTINGALE TD, Pattni K, Hume AN, Seabra MC and Cutler DF (2009). Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood  vol. 113, (20) 5010-5018. 10.1182/blood-2008-09-181206


Lui-Roberts WWY, Ferraro F, Nightingale TD and Cutler DF (2008). Aftiphilin and γ-synergin are required for secretagogue sensitivity of weibel-palade bodies in endothelial cells. Molecular Biology of The Cell  vol. 19, (12) 5072-5081. 10.1091/mbc.E08-03-0301
Metcalf DJ, Nightingale TD, Zenner HL, Lui-Roberts WW and Cutler DF (2008). Formation and function of Weibel-Palade bodies. Journal of Cell Science  vol. 121, (1) 19-27. 10.1242/jcs.03494