Dr Rosalind Hannen

Rosalind Hannen

Lecturer

CBCR
QMUL and founder of Keratify

Research

Skin-on-chip, Dermatology, Skin testing, Regulatory testing, Skin toxicology

Interests

My interests are in creating highly human-representative skin models to fully replicate human skin responses. By recreating or maintaining full physiological features of human skin, from barrier function to immune response, high testing errors that impact toxicology and efficacy analysis in dermatology can be eliminated.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2026

Engineering microbial symbiosis and dysbiosis reveals a new AhR-mediated mechanism underlying dandruff pathogenesis
McPolin-Hall E, Stephen AS, Pardieu C, Georgeu G, Allaker RP, Bhogal RK, Pople JE, Philpott MP et al.
British Journal of Dermatology, Oxford University Press (Oup) 
23-05-2026
P33 Quantification of metabolic pathways in human hair follicles and their response to caffeine and N,N-dimethylglycine
Farren C, Biddle A, Völker JM, Wiesche ESZ, Philpott M, Hannen R
British Journal of Dermatology, Oxford University Press (Oup) vol. 194 (1) 
06-01-2026
P41 Characterizing the impact of ageing/inflammaging on autophagy integrity in the skin
Ng’andu K, Philpott M, Hannen R, People J, Bhogal R, Bergamaschi D
British Journal of Dermatology, Oxford University Press (Oup) vol. 194 (1) 
06-01-2026

2023

O06 Exploring host–microbiome–immune interactions using singular and multispecies inoculations in optimized 3D skin models
McPolin-Hall E, Stephen A, Pardieu C, Allaker R, Philpott M, Bhogal R, Pople J, Hannen R
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e6-e6.  
07-07-2023
O09 Dynamic impact of chronic inflammation on epidermal autophagy pathway
Uddin N, Ostano P, Chiorino G, di Domizio J, Gilliet M, Philpott M, Hannen R, Bergamaschi D
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e7-e8.  
07-07-2023
910 Exploring host-microbiome interactions in optimised 3D skin models
McPolin-Hall E, Stephens A, Pardieu C, Allaker R, Philpott M, Pople J, Hannen R
Journal of Investigative Dermatology, Elsevier vol. 143 (5) 
01-05-2023
Chapter 15 Skin tissue engineering and keratinocyte stem cell therapy
Hannen R, Connelly J, Myers S, Ojeh N
In Tissue Engineering, Elsevier 491-532.  
01-01-2023

2022

347 Chronic Inflammation of Keratinocytes Leads to Autophagy Impairment in Psoriasis
Uddin N, Ostano P, Chiorino G, Philpott M, Hannen R, Bergamaschi D
Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022
200 Optimised 3D skin models incorporating microbiome and host immune responses
McPolin-Hall E, Stephens A, Pardieu C, Allaker R, Philpott M, Pople J, Hannen R
Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022
233 A novel ex vivo skin culture device enables clinically representative skin testing
Kung C, Lawrence K, Ahmed Z, McPolin-Hall E, Barnard I, Brand S, Frame J, Philpott M et al.
Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022
222 Enhanced Environmental Control Resolves Limitations of Standard Skin Culture by Mimicking Physiological Conditions
Lawrence K, Kung C, Ahmed Z, Bashall S, Brand S, Frame J, Philpott M, Castrejon-Pita R et al.
Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022
ESDR347 - Chronic Inflammation of Keratinocytes Leads to Autophagy Impairment in Psoriasis
Begum Uddin N, Ostano P, Chiorino G, Philpott M, Hannen R, Bergamaschi D
, Morressier 
27-09-2022
ESDR233 - A novel ex vivo skin culture device enables clinically representative skin testing
Kung C-P, Lawrence K, Ahmed Z, McPolin-Hall E, Barnard I, Brand S, Frame J, Philpott M et al.
, Morressier 
26-09-2022
ESDR200 - Optimised 3D skin models incorporating microbiome and host immune responses
McPolin-Hall E, Stephens A, Pardieu C, Allaker R, Philpott M, Pople J, Hannen R
, Morressier 
26-09-2022
Skin tissue engineering and keratinocyte stem cell therapy
Hannen R, Connelly J, Myers S
In Tissue Engineering Third Edition 491-532.  
01-01-2022

2020

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment
Jacob J, Nadkarni S, Peng Q, Tung SL, Hannen RF, Mohseni YR, Scotta C, Marelli-Berg FM et al.
Molecular Therapy Advances, Elsevier vol. 20, 324-336.  
10-12-2020
Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome
Evans EA, Sayers SR, Kodji X, Xia Y, Shaikh M, Rizvi A, Frame J, Brain SD et al.
Molecular Metabolism, Elsevier vol. 41 
26-06-2020
Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage
Tung SL, Fanelli G, Matthews RI, Bazoer J, Letizia M, Vizcay-Barrena G, Faruqu FN, Philippeos C et al.
Frontiers in Cell and Developmental Biology, Frontiers vol. 8 
20-05-2020

2018

717 Dysfunctional stress response in psoriatic keratinocytes
Hannen R, Leigh I, Philpott M
 
01-05-2018
1005 The skin: A new player in the control of whole-body glucose homeostasis
Evans E, Brain S, Philpott M, Caton P, Hannen R
Journal of Investigative Dermatology, Elsevier vol. 138 (5) 
01-05-2018

2017

Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis
Caton PW, Evans EA, Philpott MP, Hannen RF
Current Opinion in Pharmacology, Elsevier vol. 37, 59-64.  
03-10-2017
131 Stressed out keratinocytes, new insights into psoriasis lesion formation
Hannen RF, Asher S, Mannella V, Purdie K, Leigh I, Philpott M
 
01-10-2017
An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment
Halim L, Romano M, McGregor R, Correa I, Pavlidis P, Grageda N, Hoong S-J, Yuksel M et al.
Cell Reports, Elsevier vol. 20 (3), 757-770.  
01-07-2017
Dysfunctional Skin-Derived Glucocorticoid Synthesis Is a Pathogenic Mechanism of Psoriasis
Hannen R, Udeh-Momoh C, Upton J, Wright M, Michael A, Gulati A, Rajpopat S, Clayton N et al.
Journal of Investigative Dermatology, Elsevier vol. 137 (8), 1630-1637.  
28-03-2017
A novel skin-adipose tissue axis regulates pancreatic beta cell function
Evans EA, Sayers SR, Philpott MP, Hannen RF, Caton PW
 
01-03-2017
Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection
Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MAA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM et al.
American Journal of Transplantation, Elsevier vol. 17 (4), 931-943.  
01-02-2017

2016

Stabilising the Glucocorticoid Response in Psoriatic Skin
Hannen RF, Perez P, Lightman S, Philpott MP
 
01-01-2016

2015

Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia
Upton JH, Hannen RF, Bahta AW, Farjo N, Farjo B, Philpott MP
Journal of Investigative Dermatology, Elsevier vol. 135 (5), 1244-1252.  
03-02-2015

2011

Steroid synthesis by primary human keratinocytes; implications for skin disease.
Hannen RF, Michael AE, Jaulim A, Bhogal R, Burrin JM, Philpott MP
Biochem Biophys Res Commun vol. 404 (1), 62-67.  
07-01-2011

2008

Hyperglycaemic patients have decreased ATP-binding cassette transporter-A1 (ABCA-1) gene expression: A novel disease mechanism
Patel DC, Pavitt D, Albrecht C, Dhanjil S, Hannen R, Valabhji J, Higgins CF, Johnston DG
Atherosclerosis, Elsevier vol. 199 (1), 231-232.  
01-07-2008
StAR role for glucocorticoid synthesis in keratinocytes
Hannen RF, Michael AE, Burrin J, Philpott MP
 
01-04-2008
Cortisol synthesis and regulation of proliferation in keratinocytes
Hannen RF, Michael AE, Burrin J, Philpott M
 
01-04-2008

2007

Human skin and keratinocytes express cholesterol transporters and primary keratinocytes are capable of metabolising progesterone into cortisol
Hannen RF, Michael AE, Burrin JM, Philpott M
 
01-10-2007

Microbially-competent skin organotypics reveal dysregulated AhR signalling in microbial dysbiosis
McPolin-Hall EP, Stephen AS, Pardieu C, Georgeu G, Allaker RP, Bhogal RK, Pople JE, Philpott MP et al.
In Biorxiv 
Skin culturing apparatus and method
Hannen R, Castrejón-Pita JR
US, Europe, Patent 12286609. 
Imaging Device Adaptor
Hannen R, Ahmed Z, Lawrence K, Jakharia-Shah N
US, Europe Patent US20250328063A1.