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Dr Richard Grose

Richard Grose

Reader in Cancer Cell Biology

Barts Cancer Institute
School of Medicine & Dentistry, Queen Mary University of London

www.bartscancer.london/staff/dr-richard-grose/

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Wilcz-Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala-Dilke K and Bianchi K (2020). Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. Embo Molecular Medicine  vol. 12, (2) 10.15252/emmm.201910491

2019

Coetzee A, Grose R and Kocher H (2019). Pancreatic Cancer Organotypic Models. Curr Top Microbiol Immunol  10.1007/82_2019_155

2018

Clayton NS and Grose RP (2018). Emerging Roles of Fibroblast Growth Factor 10 in Cancer. Front Genet  vol. 9, 499-499. 10.3389/fgene.2018.00499
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR and Grose RP (2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Reports  vol. 22, (9) 2469-2481. 10.1016/j.celrep.2018.02.028

2017

Clayton NS, Wilson AS, Laurent EP, Grose RP and Carter EP (2017). Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment. Dev Dyn  vol. 246, (7) 493-501. 10.1002/dvdy.24514
Carter EP, Gopsill JA, Gomm JJ, Jones JL and Grose RP (2017). A 3D in vitro model of the human breast duct: A method to unravel myoepithelial-luminal interactions in the progression of breast cancer. Breast Cancer Research  vol. 19, (1) 10.1186/s13058-017-0843-4
Chioni A-M, Bajwa RT and Grose R (2017). 3D Organotypic Culture Model to Study Components of ERK Signaling. Springerlink  Methods Mol Biol  vol. 1487, 255-267. 10.1007/978-1-4939-6424-6_19

2016

Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P, Grose RP, Lemoine NR, Richards FM and Kocher HM (2016). Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma. Wiley  Journal of Pathology  vol. 239, (3) 286-296. 10.1002/path.4727
GROSE RP, Dawkins JBN, Wang J, maniati , heward , koniali , kocher , martin , chelala , balkwill and fitzgibbon (2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. American Association For Cancer Research  Cancer Research  10.1158/0008-5472.CAN-16-0481
Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P, Grose RP, Lemoine NR, Richards FM and Kocher HM (2016). Developing drug combinations to co-target pancreatic cancer and its supporting stroma. Pancreatology  vol. 16, (3) 10.1016/j.pan.2016.04.018
Tanner Y and Grose RP (2016). Dysregulated FGF signalling in neoplastic disorders. Elsevier: 12 Months  Seminars in Cell and Developmental Biology  vol. 53, 126-135. 10.1016/j.semcdb.2015.10.012

2015

Milagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R, Bowtell DDL, Hochhauser D and Balkwill FR (2015). Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL6 antibodies, with implications for combined therapy in ovarian cancer. Cancer Research  vol. 75, (7) 1255-1264. 10.1158/0008-5472.CAN-14-1801
Carter EP, Fearon AE and Grose RP (2015). Careless talk costs lives: Fibroblast growth factor receptor signalling and the consequences of pathway malfunction. Trends in Cell Biology  vol. 25, (4) 221-233. 10.1016/j.tcb.2014.11.003

2014

Coleman SJ, Bruce C, Chioni A-M, Kocher HM and Grose RP (2014). The ins and outs of fibroblast growth factor receptor signalling. Clin Sci (Lond)  vol. 127, (4) 217-231. 10.1042/CS20140100
Coleman SJ, Watt J, Arumugam P, Solaini L, Carapuca E, Ghallab M, Grose RP and Kocher HM (2014). Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation. World J Gastroenterol  vol. 20, (26) 8471-8481. 10.3748/wjg.v20.i26.8471
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevi N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni A-M, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu Y-J (2014). Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol  vol. 232, (5) 566-577. 10.1002/path.4327
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM and Grose RP (2014). Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion. Embo Mol Med  vol. 6, (4) 467-481. 10.1002/emmm.201302698
Coleman S, Chioni A-M, Ghallab M, Anderson R, Lemoine N, Kocher H and Grose R (2014). Nuclear FGFR signalling as a driving force in pancreatic cancer. Pancreatology  vol. 14, (2) 10.1016/j.pan.2014.03.014
Fearon AE and Grose RP (2014). Grb-ing receptor activation by the tail. Nat Struct Mol Biol  vol. 21, (2) 113-114. 10.1038/nsmb.2767
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM, Kamam S, Chioni A-M, Gould D, Lorincz AT, Oliver T, Chelala C, Thomas GM, Mather S, Berney D, Young BD and Lu Y-J (2014). Identification of ZDHHC14 as a novel human tumour suppressor: gene. International Journal of Molecular Medicine  vol. 34, S90-S90.
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni AM, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu YJ (2014). Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)). Journal of Pathology  vol. 234, (1) 10.1002/path.4396
Coleman SJ, Grose RP and Kocher HM (2014). Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma. J Hepatocell Carcinoma  vol. 1, 43-54. 10.2147/JHC.S48958

2013

Fearon AE, Gould CR and Grose RP (2013). FGFR signalling in women's cancers. Int J Biochem Cell Biol  vol. 45, (12) 2832-2842. 10.1016/j.biocel.2013.09.017
Guasti L, Candy Sze WC, McKay T, Grose R and King PJ (2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Mol Cell Endocrinol  vol. 371, (1-2) 182-188. 10.1016/j.mce.2013.01.014
Guasti L, Candy Sze WC, McKay T, Grose R and King PJ (2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Molecular and Cellular Endocrinology  vol. 371, (1-2) 182-188. 10.1016/j.mce.2013.01.014
Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP and Kocher H (2013). 538 Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion. Gastroenterology  vol. 144, (5) s-98. 10.1016/s0016-5085(13)60358-3
Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C and Salomoni P (2013). The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene  vol. 32, (6) 699-712. 10.1038/onc.2012.111
Robbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR and Grose RP (2013). Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing. Plos One  vol. 8, (11) 10.1371/journal.pone.0078839
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Grose RP and Kocher HM (2013). Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells is necessary for pancreatic cancer cell invasion. Pancreatology  vol. 13, (1) e10-e11. 10.1016/j.pan.2012.12.032

2012

Meyer M, Müller A-K, Yang J, Moik D, Ponzio G, Ornitz DM, Grose R and Werner S (2012). FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin. J Cell Sci  vol. 125, (Pt 23) 5690-5701. 10.1242/jcs.108167
Chioni A-M and Grose R (2012). FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior. J Cell Biol  vol. 197, (6) 801-817. 10.1083/jcb.201108077
(2012). Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol  vol. 227, (1) 81-93. 10.1002/path.3982
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Chaplin T, Xue L, Xu M, Foster JM, James S, Chioni AM, Jeetle S, Vasiljevi NA, Marzec J, Gould D, Jones L, Lorincz AT, Oliver RTD, Mather SJ, Shipley JM, Berney DM, Young BD and Lu Y-J (2012). Abstract 4858: Identification of ZDHHC14 as a novel tumor suppressor gene commonly downregulated in human cancers. 10.1158/1538-7445.am2012-4858
Jarosz M, Robbez-Masson L, Chioni A-M, Cross B, Rosewell I and Grose R (2012). Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. Plos One  vol. 7, (6) 10.1371/journal.pone.0039436

2011

Coleman SJ, Myrto-Chioni A, Grose RP and Kocher H (2011). Investigating the Role of FGF Signaling in Pancreatic Cancer. Gastroenterology  vol. 140, (5) s-714. 10.1016/s0016-5085(11)62965-x
Chioni A-M, Jones LJ and Grose RP (2011). Abstract 1101: A novel role for FGFR in breast cancer. 10.1158/1538-7445.am2011-1101

2010

Yang J, Meyer M, Müller A-K, Böhm F, Grose R, Dauwalder T, Verrey F, Kopf M, Partanen J, Bloch W, Ornitz DM and Werner S (2010). Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. J Cell Biol  vol. 188, (6) 935-952. 10.1083/jcb.200910126
Turner N and Grose R (2010). Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer  vol. 10, (2) 116-129. 10.1038/nrc2780
Chioni A-M, Shao D, Grose R and Djamgoz MBA (2010). Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration. Int J Biochem Cell Biol  vol. 42, (2) 346-358. 10.1016/j.biocel.2009.11.021
(2010). Regulation of lymphatic-blood vessel separation by endothelial Rac1 (vol 136, pg 4043, 2009). Development  vol. 137, (2) 359-359. 10.1242/dev.047597
Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F and Wan H (2010). Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. Plosone  Plos One  vol. 5, (12) 10.1371/journal.pone.0014211

2009

(2009). Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development  vol. 136, (23) 4043-4053. 10.1242/dev.035014
Chioni A-M and Grose R (2009). Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3). Eur J Cell Biol  vol. 88, (7) 371-384. 10.1016/j.ejcb.2009.01.004

2008

Chioni A-M and Grose R (2008). Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesis. Fibrogenesis Tissue Repair  vol. 1, (1) 10.1186/1755-1536-1-8

2007

Grose R, Fantl V, Werner S, Chioni A-M, Jarosz M, Rudling R, Cross B, Hart IR and Dickson C (2007). The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Embo J  vol. 26, (5) 1268-1278. 10.1038/sj.emboj.7601583

2006

Grose R (2006). Fibroblast growth factor receptor 2-IIIb is a critical mediator of intercellular signalling in development and disease. J Invest Derm Symp P  vol. 11, (1) 142-142.

2005

Grose R and Dickson C (2005). Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev  vol. 16, (2) 179-186. 10.1016/j.cytogfr.2005.01.003
Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A and Hodivala-Dilke K (2005). Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nat Med  vol. 11, (2) 167-174. 10.1038/nm1165

2004

Grose R and Werner S (2004). Wound-healing studies in transgenic and knockout mice. Mol Biotechnol  vol. 28, (2) 147-166. 10.1385/MB:28:2:147
Zhang HB, Dessimoz J, Beyer TA, Krampert M, Williams LT, Werner S and Grose R (2004). Fibroblast growth factor receptor 1-lllb is dispensable for skin morphogenesis and wound healing. Eur J Cell Biol  vol. 83, (1) 3-11. 10.1078/0171-9335-00355
Grose R (2004). Common ground in the transcriptional profiles of wounds and tumors. Genome Biol  vol. 5, (6) 10.1186/gb-2004-5-6-228

2003

Young P, Boussadia O, Halfter H, Grose R, Berger P, Leone DP, Robenek H, Charnay P, Kemler R and Suter U (2003). E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles. Embo J  vol. 22, (21) 5723-5733. 10.1093/emboj/cdg560
Petiot A, Conti FJA, Grose R, Revest J-M, Hodivala-Dilke KM and Dickson C (2003). A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development  vol. 130, (22) 5493-5501. 10.1242/dev.00788
Grose R (2003). Epithelial migration: open your eyes to c-Jun. Curr Biol  vol. 13, (17) R678-R680. 10.1016/s0960-9822(03)00607-9
Beyer TA, Werner S, Dickson C and Grose R (2003). Fibroblast growth factor 22 and its potential role during skin development and repair. Exp Cell Res  vol. 287, (2) 228-236. 10.1016/S0014-4827(03)00139-3
Werner S and Grose R (2003). Regulation of wound healing by growth factors and cytokines. Physiol Rev  vol. 83, (3) 835-870. 10.1152/physrev.2003.83.3.835
(2003). Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells. Curr Biol  vol. 13, (13) 1122-1128. 10.1016/s0960-9822(03)00396-8
Grose R and Werner S (2003). Wound Healing Studies in Transgenic and Knockout Mice. Wound Healing  10.1385/1-59259-332-1:191
Grose R and Werner S (2003). Wound healing studies in transgenic and knockout mice. A review. Methods Mol Med  vol. 78, 191-216. 10.1385/1-59259-332-1:191

2002

Wood W, Jacinto A, Grose R, Woolner S, Gale J, Wilson C and Martin P (2002). Wound healing recapitulates morphogenesis in Drosophila embryos. Nat Cell Biol  vol. 4, (11) 907-912. 10.1038/ncb875
Grose R, Werner S, Kessler D, Tuckermann J, Huggel K, Durka S and Reichardt HM (2002). A role for endogenous glucocorticoids in wound repair. Embo Rep  vol. 3, (6) 575-582. 10.1093/embo-reports/kvf119
Grose R, Hutter C, Bloch W, Thorey I, Watt FM, Fässler R, Brakebusch C and Werner S (2002). A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development  vol. 129, (9) 2303-2315.
Grose R and Werner S (2002). An aPPARently protective mechanism for keratinocytes in wounded skin. Trends Mol Med  vol. 8, (4) 149-151. 10.1016/s1471-4914(02)02312-2
Grose R, Harris BS, Cooper L, Topilko P and Martin P (2002). Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse. Dev Dyn  vol. 223, (3) 371-378. 10.1002/dvdy.10064