Publications

Publications of specific relevance to Predictive in vitro Models
2020

Wilcz-Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J,
Grose R, Szabadkai G, Jones L,
Hodivala-Dilke K and Bianchi K (2020).
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. Embo Molecular Medicine vol. 12, (2)
10.15252/emmm.2019104912019
2018

Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR and
Grose RP (2018).
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Reports vol. 22, (9) 2469-2481.
10.1016/j.celrep.2018.02.0282017

Clayton NS, Wilson AS, Laurent EP,
Grose RP and Carter EP (2017).
Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment. Dev Dyn vol. 246, (7) 493-501.
10.1002/dvdy.24514
Carter EP, Gopsill JA, Gomm JJ, Jones JL and
Grose RP (2017).
A 3D in vitro model of the human breast duct: A method to unravel myoepithelial-luminal interactions in the progression of breast cancer. Breast Cancer Research vol. 19, (1)
10.1186/s13058-017-0843-42016

Chioni A-M, Bajwa RT and
Grose R (2016).
3D Organotypic Culture Model to Study Components of ERK Signaling. Springerlink Methods Mol Biol vol. 1487, 255-267.
10.1007/978-1-4939-6424-6_19
GROSE RP, Dawkins JBN, Wang J, maniati ,
heward , koniali , kocher , martin , chelala ,
balkwill and fitzgibbon (2016).
Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. American Association For Cancer Research Cancer Research 10.1158/0008-5472.CAN-16-0481
Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P,
Grose RP, Lemoine NR, Richards FM and Kocher HM (2016).
Developing drug combinations to co-target pancreatic cancer and its supporting stroma. Pancreatology vol. 16, (3)
10.1016/j.pan.2016.04.018
Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P,
Grose RP, Lemoine NR, Richards FM and Kocher HM (2016).
Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma. Wiley Journal of Pathology vol. 239, (3) 286-296.
10.1002/path.4727
Tanner Y and
Grose RP (2016).
Dysregulated FGF signalling in neoplastic disorders. Elsevier: 12 Months Seminars in Cell and Developmental Biology vol. 53, 126-135.
10.1016/j.semcdb.2015.10.0122015

Milagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE,
Grose R, Bowtell DDL, Hochhauser D and
Balkwill FR (2015).
Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL6 antibodies, with implications for combined therapy in ovarian cancer. Cancer Research vol. 75, (7) 1255-1264.
10.1158/0008-5472.CAN-14-1801
Carter EP, Fearon AE and
Grose RP (2015).
Careless talk costs lives: Fibroblast growth factor receptor signalling and the consequences of pathway malfunction. Trends in Cell Biology vol. 25, (4) 221-233.
10.1016/j.tcb.2014.11.0032014

Coleman SJ, Bruce C, Chioni A-M, Kocher HM and
Grose RP (2014).
The ins and outs of fibroblast growth factor receptor signalling. Clin Sci (Lond) vol. 127, (4) 217-231.
10.1042/CS20140100
Coleman SJ, Watt J, Arumugam P, Solaini L, Carapuca E, Ghallab M,
Grose RP and Kocher HM (2014).
Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation. World J Gastroenterol vol. 20, (26) 8471-8481.
10.3748/wjg.v20.i26.8471
Yeste-Velasco M, Mao X,
Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevi N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni A-M, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu Y-J (2014).
Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol vol. 232, (5) 566-577.
10.1002/path.4327
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM and
Grose RP (2014).
Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion. Embo Mol Med vol. 6, (4) 467-481.
10.1002/emmm.201302698
Coleman S, Chioni A-M, Ghallab M, Anderson R, Lemoine N, Kocher H and
Grose R (2014).
Nuclear FGFR signalling as a driving force in pancreatic cancer. Pancreatology vol. 14, (2)
10.1016/j.pan.2014.03.014
Fearon AE and
Grose RP (2014).
Grb-ing receptor activation by the tail. Nat Struct Mol Biol vol. 21, (2) 113-114.
10.1038/nsmb.2767
Yeste-Velasco M, Mao X,
Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM, Kamam S, Chioni A-M, Gould D, Lorincz AT, Oliver T, Chelala C, Thomas GM, Mather S, Berney D, Young BD and Lu Y-J (2014).
Identification of ZDHHC14 as a novel human tumour suppressor: gene. International Journal of Molecular Medicine vol. 34, S90-S90.

Yeste-Velasco M, Mao X,
Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni AM, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu YJ (2014).
Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)). Journal of Pathology vol. 234, (1)
10.1002/path.4396
Coleman SJ,
Grose RP and Kocher HM (2014).
Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma. J Hepatocell Carcinoma vol. 1, 43-54.
10.2147/JHC.S489582013

Guasti L, Candy Sze WC, McKay T,
Grose R and King PJ (2013).
FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Mol Cell Endocrinol vol. 371, (1-2) 182-188.
10.1016/j.mce.2013.01.014
Guasti L, Candy Sze WC, McKay T,
Grose R and King PJ (2013).
FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Molecular and Cellular Endocrinology vol. 371, (1-2) 182-188.
10.1016/j.mce.2013.01.014
Coleman S, Chioni A-M, Ghallab M, Lemoine N,
Grose RP and Kocher H (2013).
538 Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion. Gastroenterology vol. 144, (5) s-98.
10.1016/s0016-5085(13)60358-3
Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M,
Grose R, Jones C and Salomoni P (2013).
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene vol. 32, (6) 699-712.
10.1038/onc.2012.111
Robbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR and
Grose RP (2013).
Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing. Plos One vol. 8, (11)
10.1371/journal.pone.0078839
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR,
Grose RP and Kocher HM (2013).
Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells is necessary for pancreatic cancer cell invasion. Pancreatology vol. 13, (1) e10-e11.
10.1016/j.pan.2012.12.0322012

Meyer M, Müller A-K, Yang J, Moik D, Ponzio G, Ornitz DM,
Grose R and Werner S (2012).
FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin. J Cell Sci vol. 125, (Pt 23) 5690-5701.
10.1242/jcs.108167
Chioni A-M and
Grose R (2012).
FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior. J Cell Biol vol. 197, (6) 801-817.
10.1083/jcb.201108077
Tsang SM, Brown L, Lin K, Liu L, Piper K#29501#, O'Toole EA#20462#, Grose R#21436#, Hart IR, Garrod DR, Fortune F#21546# and Wan H#19616# (2012).
Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol vol. 227, (1) 81-93.
10.1002/path.3982
Yeste-Velasco M, Mao X,
Grose R, Kudahetti SC, Lin D, Chaplin T, Xue L, Xu M, Foster JM, James S, Chioni AM, Jeetle S, Vasiljevi NA, Marzec J, Gould D, Jones L, Lorincz AT, Oliver RTD, Mather SJ, Shipley JM, Berney DM, Young BD and Lu Y-J (2012).
Abstract 4858: Identification of ZDHHC14 as a novel tumor suppressor gene commonly downregulated in human cancers. 10.1158/1538-7445.am2012-4858
Jarosz M, Robbez-Masson L, Chioni A-M, Cross B, Rosewell I and
Grose R (2012).
Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. Plos One vol. 7, (6)
10.1371/journal.pone.00394362011

Coleman SJ, Myrto-Chioni A,
Grose RP and Kocher H (2011).
Investigating the Role of FGF Signaling in Pancreatic Cancer. Gastroenterology vol. 140, (5) s-714.
10.1016/s0016-5085(11)62965-x2010

Yang J, Meyer M, Müller A-K, Böhm F,
Grose R, Dauwalder T, Verrey F, Kopf M, Partanen J, Bloch W, Ornitz DM and Werner S (2010).
Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. J Cell Biol vol. 188, (6) 935-952.
10.1083/jcb.200910126
Turner N and
Grose R (2010).
Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer vol. 10, (2) 116-129.
10.1038/nrc2780
Chioni A-M, Shao D,
Grose R and Djamgoz MBA (2010).
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration. Int J Biochem Cell Biol vol. 42, (2) 346-358.
10.1016/j.biocel.2009.11.021
D'Amico G, Jones DT, Nye E, Sapienza K#19996#, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R#21436#, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V and Hodivala-Dilke KM#21318# (2010).
Regulation of lymphatic-blood vessel separation by endothelial Rac1 (vol 136, pg 4043, 2009). Development vol. 137, (2) 359-359.
10.1242/dev.047597
Tsang SM, Liu L, Teh M-T, Wheeler A,
Grose R, Hart IR, Garrod DR, Fortune F and Wan H (2010).
Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. Plosone Plos One vol. 5, (12)
10.1371/journal.pone.00142112009

D'Amico G, Jones DT, Nye E, Sapienza K#19996#, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R#21436#, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V and Hodivala-Dilke KM#21318# (2009).
Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development vol. 136, (23) 4043-4053.
10.1242/dev.035014
Chioni A-M and
Grose R (2009).
Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3). Eur J Cell Biol vol. 88, (7) 371-384.
10.1016/j.ejcb.2009.01.0042008

Chioni A-M and
Grose R (2008).
Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesis. Fibrogenesis Tissue Repair vol. 1, (1)
10.1186/1755-1536-1-82007
Grose R, Fantl V, Werner S, Chioni A-M, Jarosz M, Rudling R, Cross B, Hart IR and Dickson C (2007).
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Embo J vol. 26, (5) 1268-1278.
10.1038/sj.emboj.76015832006
Grose R (2006).
Fibroblast growth factor receptor 2-IIIb is a critical mediator of intercellular signalling in development and disease. J Invest Derm Symp P vol. 11, (1) 142-142.
2005

Reynolds LE, Conti FJ, Lucas M,
Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A and
Hodivala-Dilke K (2005).
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nat Med vol. 11, (2) 167-174.
10.1038/nm11652004
Grose R and Werner S (2004).
Wound-healing studies in transgenic and knockout mice. Mol Biotechnol vol. 28, (2) 147-166.
10.1385/MB:28:2:147
Zhang HB, Dessimoz J, Beyer TA, Krampert M, Williams LT, Werner S and
Grose R (2004).
Fibroblast growth factor receptor 1-lllb is dispensable for skin morphogenesis and wound healing. Eur J Cell Biol vol. 83, (1) 3-11.
10.1078/0171-9335-003552003

Young P, Boussadia O, Halfter H,
Grose R, Berger P, Leone DP, Robenek H, Charnay P, Kemler R and Suter U (2003).
E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles. Embo J vol. 22, (21) 5723-5733.
10.1093/emboj/cdg560
Petiot A, Conti FJA,
Grose R, Revest J-M,
Hodivala-Dilke KM and Dickson C (2003).
A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development vol. 130, (22) 5493-5501.
10.1242/dev.00788
Beyer TA, Werner S, Dickson C and
Grose R (2003).
Fibroblast growth factor 22 and its potential role during skin development and repair. Exp Cell Res vol. 287, (2) 228-236.
10.1016/S0014-4827(03)00139-3
Martin P, D'Souza D, Martin J, Grose R#21436#, Cooper L, Maki R and McKercher SR (2003).
Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells. Curr Biol vol. 13, (13) 1122-1128.
10.1016/s0960-9822(03)00396-82002

Wood W, Jacinto A,
Grose R, Woolner S, Gale J, Wilson C and Martin P (2002).
Wound healing recapitulates morphogenesis in Drosophila embryos. Nat Cell Biol vol. 4, (11) 907-912.
10.1038/ncb875
Grose R, Werner S, Kessler D, Tuckermann J, Huggel K, Durka S and Reichardt HM (2002).
A role for endogenous glucocorticoids in wound repair. Embo Rep vol. 3, (6) 575-582.
10.1093/embo-reports/kvf119
Grose R, Hutter C, Bloch W, Thorey I, Watt FM, Fässler R, Brakebusch C and Werner S (2002).
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development vol. 129, (9) 2303-2315.
Grose R, Harris BS, Cooper L, Topilko P and Martin P (2002).
Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse. Dev Dyn vol. 223, (3) 371-378.
10.1002/dvdy.10064