Prof Richard Grose
Professor of Cancer Cell Biology
Barts Cancer Institute
Queen Mary University of London
Queen Mary University of London
Research
Cellular crosstalk, 3D modelling, Breast Cancer, Pancreatic Cancer, Receptor tyrosine kinases, Fibroblast Growth Factors
Interests
We work with both cell line-based and primary cell-based 2D and 3D model systems, studying cellular crosstalk and tumour-stromal interactions in solid tumours - with a focus on breast and pancreatic cancer. We are particularly interested in interactions between luminal, myoepithelial and immune cells in the progression of Ductal Carcinoma in situ in the breast - including understanding how these cells interact with the surrounding stroma, with a particular focus on proteolytic activity. In pancreatic cancer, we are studying cancer-stellate cell interactions. We have expertise in studying a number of cell surface receptors and currently have projects involving FGFRs, EGFR, HER2, Cannabinoid receptors, Purinergic signalling and the Ephrin-Eph receptor axis.Publications of specific relevance to Predictive in vitro Models
2023
In silico targeting of colony-stimulating factor-1 receptor: delineating immunotherapy in cancerAzhar Z, Grose RP, Raza A, Raza Z
Exploration of Targeted Anti-Tumor Therapy, Open Exploration Publishing, 727-742.
31-08-2023
The Future of Precision OncologyRulten SL, Grose RP, Gatz SA, Jones JL, Cameron AJM
International Journal of Molecular Sciences, Mdpi Ag vol. 24 (16), 12613-12613.
09-08-2023
ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradationGibson SV, Madzharova E, Tan AC, Allen MD, Keller UAD, Louise Jones J, Carter EP, Grose RP
Matrix Biology, Elsevier Bv vol. 121, 74-89.
01-08-2023
Everybody needs good neighbours: the progressive DCIS microenvironmentGibson SV, Roozitalab RM, Allen MD, Jones JL, Carter EP, Grose RP
Trends in Cancer, Elsevier Bv vol. 9 (4), 326-338.
01-04-2023
HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 InductionClayton NS, Carter EP, Fearon AE, Heward JA, Rodríguez Fernández L, Boughetane L, Wilkes EH, Cutillas PR et al.
International Journal of Molecular Sciences, Mdpi Ag vol. 24 (7), 6228-6228.
25-03-2023
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasionTomas Bort E, Joseph MD, Wang Q, Carter EP, Roth NJ, Gibson J, Samadi A, Kocher HM et al.
Elife, Elife Sciences Publications, Ltd vol. 12
21-03-2023
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progressionGibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A et al.
Npj Breast Cancer, Springer Science and Business Media Llc vol. 9 (1)
02-03-2023
Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin openingDisease Models & Mechanisms, The Company of Biologists vol. 16 (2)
01-02-2023
2022
Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1Coetzee AS, Carter EP, Rodríguez-Fernández L, Heward J, Wang Q, Karim SA, Boughetane L, Milton C et al.
Oncogene, Springer Science and Business Media Llc
10-11-2022
Single‐cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancerYu Z, Zhang J, Zhang Q, Wei S, Shi R, Zhao R, An L, Grose R et al.
Cell Proliferation, Wiley vol. 55 (6)
13-05-2022
Expression of programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand (PD-L1) in adenocarcinomas of the gastroesophageal junction change significantly after neoadjuvant treatmentJomrich G, Kollmann D, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C et al.
European Journal of Surgical Oncology, Elsevier Bv vol. 48 (2), 383-390.
01-02-2022
The Obscure Potential of AHNAK2Zardab M, Stasinos K, Grose RP, Kocher HM
Cancers, Mdpi Ag vol. 14 (3), 528-528.
21-01-2022
FGF signalling facilitates cervical cancer progressionMahmood HA, Tomas Bort E, Walker AJ, Grose RP, Chioni A
The Febs Journal, Wiley vol. 289 (12), 3440-3456.
03-01-2022
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasionMurray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al.
Cell Reports, Elsevier vol. 38 (4)
01-01-2022
2021
Biological Significance and Targeting of the FGFR Axis in CancerChioni A-M, Grose RP
Cancers, Mdpi Ag vol. 13 (22), 5681-5681.
13-11-2021
Tumour microenvironment 3D-modelling: simplicity to complexity and back againCarter EP, Roozitalab R, Gibson SV, Grose RP
Trends in Cancer, Elsevier Bv vol. 7 (11), 1033-1046.
01-11-2021
Quantitative Super-Resolution Imaging for the Analysis of GPCR OligomerizationJoseph MD, Tomas Bort E, Grose RP, McCormick PJ, Simoncelli S
Biomolecules, Mdpi Ag vol. 11 (10), 1503-1503.
12-10-2021
Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapyJomrich G, Kollmann D, Wilfing L, Radosavljevic S, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A et al.
European Surgery, Springer Science and Business Media Llc vol. 53 (6), 287-293.
05-05-2021
Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic CancerCarter EP, Coetzee AS, Tomas Bort E, Wang Q, Kocher HM, Grose RP
Cells, Mdpi Ag vol. 10 (4), 847-847.
08-04-2021
Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruptionAdams SD, Csere J, D’angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM et al.
Current Biology, Elsevier vol. 31 (7), 1403-1416.e7.
15-02-2021
Hallmarks of cancer—the new testamentSenga SS, Grose RP
Open Biology, The Royal Society vol. 11 (1)
01-01-2021
2020
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathwayWilcz‐Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R et al.
Embo Molecular Medicine, Springer Nature vol. 12 (2)
13-01-2020
2018
Emerging Roles of Fibroblast Growth Factor 10 in CancerClayton NS, Grose RP
Frontiers in Genetics, Frontiers Media Sa vol. 9
24-10-2018
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven CancerFearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y et al.
Cell Reports, Elsevier Bv vol. 22 (9), 2469-2481.
01-02-2018
2017
Fibroblast growth factor–mediated crosstalk in cancer etiology and treatmentClayton NS, Wilson AS, Laurent EP, Grose RP, Carter EP
Developmental Dynamics, Wiley vol. 246 (7), 493-501.
18-05-2017
A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancerCarter EP, Gopsill JA, Gomm JJ, Jones JL, Grose RP
Breast Cancer Research, Springer Science and Business Media Llc vol. 19 (1)
21-04-2017
2016
3D Organotypic Culture Model to Study Components of ERK SignalingChioni A-M, Bajwa RT, Grose R
, Springer New York, 255-267.
07-12-2016
Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal AdenocarcinomaDawkins JBN, Wang J, Maniati E, Heward JA, Koniali L, Kocher HM, Martin SA, Chelala C et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 76 (16), 4861-4871.
14-08-2016
Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinomaCarapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P et al.
The Journal of Pathology, Wiley vol. 239 (3), 286-296.
25-05-2016
Dysregulated FGF signalling in neoplastic disordersTanner Y, Grose RP
Seminars in Cell &Amp; Developmental Biology, Elsevier Bv vol. 53, 126-135.
01-05-2016
2015
Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunctionCarter EP, Fearon AE, Grose RP
Trends in Cell Biology, Elsevier Bv vol. 25 (4), 221-233.
01-04-2015
Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian CancerMilagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 75 (7), 1255-1264.
31-03-2015
The FGFR Receptor FamilyFearon AE, Chioni A-M, Grose RP
In Receptor Tyrosine Kinases: Family and Subfamilies, Springer International Publishing 265-295.
01-01-2015
2014
The ins and outs of fibroblast growth factor receptor signallingColeman SJ, Bruce C, Chioni A-M, Kocher HM, Grose RP
Clinical Science, Portland Press Ltd. vol. 127 (4), 217-231.
10-04-2014
Identification of Yeste‐Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljević N, Chaplin T et al.
The Journal of Pathology, Wiley vol. 232 (5), 566-577.
08-02-2014
Nuclear translocation of Coleman SJ, Chioni A, Ghallab M, Anderson RK, Lemoine NR, Kocher HM, Grose RP
Embo Molecular Medicine, Springer Science and Business Media Llc vol. 6 (4), 467-481.
06-02-2014
Grb-ing receptor activation by the tailFearon AE, Grose RP
Nature Structural &Amp; Molecular Biology, Springer Science and Business Media Llc vol. 21 (2), 113-114.
01-02-2014
Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluationColeman SJ
World Journal of Gastroenterology, Baishideng Publishing Group Inc. vol. 20 (26), 8471-8471.
01-01-2014
2013
FGFR signalling in women's cancersFearon AE, Gould CR, Grose RP
The International Journal of Biochemistry &Amp; Cell Biology, Elsevier Bv vol. 45 (12), 2832-2842.
01-12-2013
Functional Analysis of a Breast Cancer-Associated FGFR2 Single Nucleotide Polymorphism Using Zinc Finger Mediated Genome EditingRobbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR, Grose RP
Plos One, Public Library of Science (Plos) vol. 8 (11), e78839-e78839.
12-11-2013
FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development.Guasti L, Candy Sze WC, McKay T, Grose R, King PJ
Mol Cell Endocrinol vol. 371 (1-2), 182-188.
22-05-2013
2012
FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skinMeyer M, Müller A-K, Yang J, Moik D, Ponzio G, Ornitz DM, Grose R, Werner S
Journal of Cell Science, The Company of Biologists vol. 125 (23), 5690-5701.
01-12-2012
Fibroblast Growth Factor 22 Is Not Essential for Skin Development and Repair but Plays a Role in TumorigenesisJarosz M, Robbez-Masson L, Chioni A-M, Cross B, Rosewell I, Grose R
Plos One, Public Library of Science (Plos) vol. 7 (6), e39436-e39436.
21-06-2012
FGFR1 cleavage and nuclear translocation regulates breast cancer cell behaviorChioni A-M, Grose R
Journal of Cell Biology, Rockefeller University Press vol. 197 (6), 801-817.
04-06-2012
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cellsGalavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F et al.
Oncogene, Springer Science and Business Media Llc vol. 32 (6), 699-712.
23-04-2012
Non‐junctional human desmoglein 3 acts as an upstream regulator of Src in E‐cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgarisTsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR et al.
The Journal of Pathology, Wiley vol. 227 (1), 81-93.
17-02-2012
2010
Desmoglein 3, via an Interaction with E-cadherin, Is Associated with Activation of SrcTsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F et al.
Plos One vol. 5 (12)
03-12-2010
Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasisYang JX, Meyer M, Muller AK, Bohm F, Grose R, Dauwalder T, Verrey F, Kopf M et al.
J Cell Biol vol. 188 (6), 935-952.
22-03-2010
Fibroblast growth factor signalling: from development to cancerTurner N, Grose R
Nat Rev Cancer vol. 10 (2), 116-129.
01-02-2010
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: Activity-dependent positive feedback and cellular migrationChioni AM, Shao DM, Grose R, Djamgoz MBA
Int J Biochem Cell B vol. 42 (2), 346-358.
01-02-2010
Regulation of lymphatic-blood vessel separation by endothelial Rac1 (vol 136, pg 4043, 2009)D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V et al.
Development vol. 137 (2), 359-359.
15-01-2010
2009
Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3)Chioni AM, Grose R
Eur J Cell Biol vol. 88 (7), 371-384.
01-07-2009
2008
Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesisChioni A-M, Grose R
Fibrogenesis &Amp; Tissue Repair, Springer Science and Business Media Llc vol. 1 (1)
01-12-2008
2007
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer developmentGrose R, Fantl V, Werner S, Chioni AM, Jarosz M, Rudling R, Cross B, Hart IR et al.
Embo J vol. 26 (5), 1268-1278.
07-03-2007
2005
Fibroblast growth factor signaling in tumorigenesisGrose R, Dickson C
Cytokine Growth F R vol. 16 (2), 179-186.
01-04-2005
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C et al.
Nat Med vol. 11 (2), 167-174.
01-02-2005
2004
Wound-healing studies in transgenic and knockout miceGrose R, Werner S
Mol Biotechnol vol. 28 (2), 147-166.
01-10-2004
Fibroblast growth factor receptor 1-IIIb is dispensable for skin morphogenesis and wound healingZhang H, Dessimoz J, Beyer TA, Krampert M, Williams LT, Werner S, Grose R
European Journal of Cell Biology, Elsevier Bv vol. 83 (1), 3-11.
01-01-2004
Common ground in the transcriptional profiles of wounds and tumorsGrose R
Genome Biol vol. 5 (6)
01-01-2004
2003
E-cadherin controls adherens junctions in the epidermis and the renewal of hair folliclesYoung P
The Embo Journal, Springer Science and Business Media Llc vol. 22 (21), 5723-5733.
03-11-2003
A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning.Petiot A, Conti FJA, Grose R, Revest J-M, Hodivala-Dilke KM, Dickson C
Development vol. 130 (22), 5493-5501.
01-11-2003
Epithelial migration: Open your eyes to c-junGrose R
Curr Biol vol. 13 (17), R678-R680.
02-09-2003
Fibroblast growth factor 22 and its potential role during skin development and repairBeyer T
Experimental Cell Research, Elsevier Bv vol. 287 (2), 228-236.
15-07-2003
Regulation of wound healing by growth factors and cytokinesWerner S, Grose R
Physiol Rev vol. 83 (3), 835-870.
01-07-2003
Wound healing in the PU.1 null mouse - Tissue repair is not dependent on inflammatory cellsMartin P, D'Souza D, Martin J, Grose R, Cooper L, Maki R, McKercher SR
Curr Biol vol. 12 (13), 1122-1128.
01-07-2003
Wound Healing Studies in Transgenic and Knockout MiceGrose R, Werner S
In Wound Healing, Springer Nature 191-216.
01-01-2003
2002
Wound healing recapitulates morphogenesis in Drosophila embryosWood W, Jacinto A, Grose R, Woolner S, Gale J, Wilson C, Martin P
Nature Cell Biology, Springer Science and Business Media Llc vol. 4 (11), 907-912.
28-10-2002
A role for endogenous glucocorticoids in wound repairGrose R, Werner S, Kessler D, Tuckermann J, Huggel K, Durka S, Reichardt HM, Werner S
Embo Rep vol. 3 (6), 575-582.
01-06-2002
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repairGrose R, Hutter C, Bloch W, Thorey I, Watt FM, Fassler R, Brakebusch C, Werner S
Development vol. 129 (9), 2303-2315.
01-05-2002
An aPPARently protective mechanism for keratinocytes in wounded skinGrose R, Werner S
Trends in Molecular Medicine, Elsevier Bv vol. 8 (4), 149-151.
01-04-2002
Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouseGrose R, Harris BS, Cooper L, Topilko P, Martin P
Dev Dynam vol. 223 (3), 371-378.
01-03-2002
2000
The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healingBloch W, Huggel K, Sasaki T, Grose R, Bugnon P, Addicks K, Timpl R, Werner S
The Faseb Journal, Wiley vol. 14 (15), 2373-2376.
06-10-2000
Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytesBrakebusch C, Grose R, Quondamatteo F, Ramirez A, Jorcano JL, Pirro A, Svensson M, Herken R et al.
The Embo Journal, Springer Science and Business Media Llc vol. 19 (15), 3990-4003.
01-08-2000
1999
Parallels between wound repair and morphogenesis in the embryoGrose R, Martin P
Seminars in Cell &Amp; Developmental Biology, Elsevier Bv vol. 10 (4), 395-404.
01-08-1999
Wound Healing Studies in Transgenic and Knockout Mice: A ReviewGrose R, Werner S
, Humana Press, 191-216.
Grants
Grants of specific relevance to Predictive in vitro Models
British Council Scholarships for Women in STEM – Academic Year 2024-25Richard Grose
£180,000 British Council
01-12-2023 - 31-03-2026
Anti-Histamines as novel therapeutics in pancreatic cancerPeter McCormick and Richard Grose
£219,000 Pancreatic Cancer Research Fund
01-01-2023 - 31-12-2025
Defining the functional role of EGFR in glioblastoma tumour heterogeneityPaulo Baptista Ribeiro and Richard Grose
£185,285 Barts and the London Charity
01-10-2022 - 18-09-2027
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Jose Martin Duran, Paulo Baptista Ribeiro, Susana Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023
Deconvoluting cellular crosstalk in pancreatic cancer invasionRichard Grose
£49,511 Barts and the London Charity
01-09-2021 - 31-12-2022
TRACER 3D cultures to unravel the role of myoepithelial cells in breast cancer progressionRichard Grose
£13,363 NERC Natural Environment Research Council
01-09-2021 - 31-08-2022
Exploring the role of adenosine axis in the tumour microenvironment of pancreatic cancerRichard Grose
£107,971 Barts and the London Charity
01-09-2019 - 28-02-2023
Myoepithelial degradome in the progression of DCIS to invasiveRichard Grose
£477,911 CR-UK Cancer Research UK
01-02-2019 - 31-08-2023
Myoepithelial/luminal cross-talk in the progression of DCIS to invasive breast cancerRichard Grose
£201,816 Breast Cancer Now
01-05-2018 - 30-06-2022
Myoepithelial Dysfunction in the Progression of DCIS to invasive breast cancerRichard Grose
£10,078 Barts and the London Charity
01-09-2017 - 31-08-2018