Prof Richard Grose

Richard Grose
BSc PhD

Professor of Cancer Cell Biology

Barts Cancer Institute
Faculty of Medicine and Dentistry, Queen Mary University of London
020 7882 3574
www.groselab.com
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Research

Cellular crosstalk, 3D modelling, Breast Cancer, Pancreatic Cancer, Receptor tyrosine kinases, Fibroblast Growth Factors

Cancer Models

Interests

We work with both cell line-based and primary cell-based 2D and 3D model systems, studying cellular crosstalk and tumour-stromal interactions in solid tumours - with a focus on breast and pancreatic cancer. We are particularly interested in interactions between luminal, myoepithelial and immune cells in the progression of Ductal Carcinoma in situ in the breast - including understanding how these cells interact with the surrounding stroma, with a particular focus on proteolytic activity. In pancreatic cancer, we are studying cancer-stellate cell interactions. We have expertise in studying a number of cell surface receptors and currently have projects involving FGFRs, EGFR, HER2, Cannabinoid receptors, Purinergic signalling and the Ephrin-Eph receptor axis.

Publications of specific relevance to Predictive in vitro Models

Publications of specific relevance to Predictive in vitro Models

2023

Rulten SL, Grose RP, Gatz SA, Jones JL and Cameron AJM (2023). The Future of Precision Oncology. Mdpi  International Journal of Molecular Sciences  vol. 24, (16) 10.3390/ijms241612613
Gibson SV, Madzharova E, Tan AC, Allen MD, Keller UAD, Jones JL, Carter EP and Grose RP (2023). ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation. Elsevier  Matrix Biology  vol. 121, 74-89. 10.1016/j.matbio.2023.06.005
Clayton NS, Carter EP, Fearon AE, Heward JA, Fernández LR, Boughetane L, Wilkes EH, Cutillas PR and Grose RP (2023). HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction. Mdpi  International Journal of Molecular Sciences  vol. 24, (7) 10.3390/ijms24076228
Bort ET, Joseph MD, Wang Q, Carter EP, Roth NJ, Gibson J, Samadi A, Kocher HM, Simoncelli S, McCormick PJ and Grose RP (2023). Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. Elife  Elife  vol. 12, 10.7554/elife.86971
Gibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A, Brisken C, Peck B, Cameron AJ, Marshall JF, Jones JL, Carter EP and Grose RP (2023). TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression. Springer Nature  Npj Breast Cancer  vol. 9, (1) 10.1038/s41523-023-00513-6
Gibson SV, Roozitalab RM, Allen MD, Jones JL, Carter EP and Grose RP (2023). Everybody needs good neighbours: the progressive DCIS microenvironment. Elsevier  Trends in Cancer  vol. 9, (4) 326-338. 10.1016/j.trecan.2023.01.002
Hayat A, Carter EP, King HW, Ors A, Doe A, Teijeiro SA, Charrot S, Godinho S, Cutillas P, Mohammed H, Grose RP and Ficz G (2023). Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin opening. The Company of Biologists  Disease Models & Mechanisms  vol. 16, (2) 10.1242/dmm.049894
Azhar Z, Grose RP, Raza A and Raza Z (2023). In silico targeting of colony-stimulating factor-1 receptor: delineating immunotherapy in cancer. Open Exploration Publishing  Exploration of Targeted Anti-Tumor Therapy  vol. 4, (4) 727-742. 10.37349/etat.2023.00164

2022

Coetzee AS, Carter EP, Rodríguez-Fernández L, Heward J, Wang Q, Karim SA, Boughetane L, Milton C, Uyulur F, Morton JP, Kocher HM and Grose RP (2022). Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1. Springer Nature  Oncogene  vol. 42, (7) 491-500. 10.1038/s41388-022-02513-5
Yu Z, Zhang J, Zhang Q, Wei S, Shi R, Zhao R, An L, Grose R, Feng D and Wang H (2022). Single‐cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancer. Wiley  Cell Proliferation  vol. 55, (6) 10.1111/cpr.13249
Zardab M, Stasinos K, Grose RP and Kocher HM (2022). The Obscure Potential of AHNAK2. Mdpi  Cancers  vol. 14, (3) 10.3390/cancers14030528
Mahmood HTNA, Tomas Bort E, Walker AJ, Grose RP and Chioni AM (2022). FGF signalling facilitates cervical cancer progression. Wiley  The Federation of European Biochemical Societies (Febs) Journal  10.1111/febs.16331
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, Hodivala-Dilke K, Grose RP, Kocher HM, Gavara N, Pearce O, Cutillas P, Marshall JF and Cameron AJM (2022). Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion. Elsevier  Cell Reports  vol. 38, (4) 10.1016/j.celrep.2021.110227

2021

Chioni A-M and Grose RP (2021). Biological Significance and Targeting of the FGFR Axis in Cancer. Mdpi  Cancers  vol. 13, (22) 10.3390/cancers13225681
Joseph MD, Bort ET, Grose RP, McCormick PJ and Simoncelli S (2021). Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization. Mdpi  Biomolecules  vol. 11, (10) 10.3390/biom11101503
Jomrich G, Kollmann D, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C, Tsai Y-C, Guenova E and Schoppmann SF (2021). Expression of programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand (PD-L1) in adenocarcinomas of the gastroesophageal junction change significantly after neoadjuvant treatment. Elsevier  European Journal of Surgical Oncology  vol. 48, (2) 383-390. 10.1016/j.ejso.2021.08.016
Carter EP, Roozitalab R, Gibson SV and Grose RP (2021). Tumour microenvironment 3D-modelling: simplicity to complexity and back again. Elsevier  Trends in Cancer  vol. 7, (11) 1033-1046. 10.1016/j.trecan.2021.06.009
Jomrich G, Kollmann D, Wilfing L, Radosavljevic S, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C, Tsai Y-C, Guenova E and Schoppmann SF (2021). Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapy. Springer Nature  European Surgery  vol. 53, (6) 287-293. 10.1007/s10353-021-00700-4
Carter EP, Coetzee AS, Tomas Bort E, Wang Q, Kocher HM and Grose RP (2021). Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer. Mdpi  Cells  vol. 10, (4) 10.3390/cells10040847
Adams SD, Csere J, D’angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F and Godinho SA (2021). Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. Elsevier  Current Biology  vol. 31, (7) 1403-1416.e7. 10.1016/j.cub.2021.01.028
Senga SS and Grose RP (2021). Hallmarks of cancer—the new testament. The Royal Society  Open Biology  vol. 11, (1) 10.1098/rsob.200358

2020

Wilcz‐Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Béjar RM, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala‐Dilke K and Bianchi K (2020). Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. Springer Nature  Embo Molecular Medicine  vol. 12, (2) 10.15252/emmm.201910491

2018

Clayton NS and Grose RP (2018). Emerging Roles of Fibroblast Growth Factor 10 in Cancer. Front Genet  vol. 9, 499-499. 10.3389/fgene.2018.00499
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR and Grose RP (2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Elsevier  Cell Reports  vol. 22, (9) 2469-2481. 10.1016/j.celrep.2018.02.028

2017

Clayton NS, Wilson AS, Laurent EP, Grose RP and Carter EP (2017). Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment. Dev Dyn  vol. 246, (7) 493-501. 10.1002/dvdy.24514
Carter EP, Gopsill JA, Gomm JJ, Jones JL and Grose RP (2017). A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer. Springer Nature  Breast Cancer Research  vol. 19, (1) 10.1186/s13058-017-0843-4

2016

Chioni A-M, Bajwa RT and Grose R (2016). 3D Organotypic Culture Model to Study Components of ERK Signaling. Springerlink  Methods Mol Biol  vol. 1487, 255-267. 10.1007/978-1-4939-6424-6_19
GROSE RP, Dawkins JBN, Wang J, maniati , heward , koniali , kocher , martin , chelala , balkwill and fitzgibbon (2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. American Association For Cancer Research  Cancer Research  10.1158/0008-5472.CAN-16-0481
Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P, Grose RP, Lemoine NR, Richards FM and Kocher HM (2016). Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma. Wiley  Journal of Pathology  vol. 239, (3) 286-296. 10.1002/path.4727
Tanner Y and Grose RP (2016). Dysregulated FGF signalling in neoplastic disorders. Elsevier: 12 Months  Seminars in Cell and Developmental Biology  vol. 53, 126-135. 10.1016/j.semcdb.2015.10.012

2015

Milagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R, Bowtell DDL, Hochhauser D and Balkwill FR (2015). Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer. American Association For Cancer Research (Aacr)  Cancer Research  vol. 75, (7) 1255-1264. 10.1158/0008-5472.can-14-1801
Fearon AE, Chioni A-M and Grose RP (2015). The FGFR Receptor Family. Receptor Tyrosine Kinases: Family and Subfamilies  Springer Nature  10.1007/978-3-319-11888-8_6

2014

Carter EP, Fearon AE and Grose RP (2014). Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction. Elsevier  Trends in Cell Biology  vol. 25, (4) 221-233. 10.1016/j.tcb.2014.11.003
Coleman SJ, Bruce C, Chioni A-M, Kocher HM and Grose RP (2014). The ins and outs of fibroblast growth factor receptor signalling. Clin Sci (Lond)  vol. 127, (4) 217-231. 10.1042/CS20140100
Coleman SJ, Watt J, Arumugam P, Solaini L, Carapuca E, Ghallab M, Grose RP and Kocher HM (2014). Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation. World J Gastroenterol  vol. 20, (26) 8471-8481. 10.3748/wjg.v20.i26.8471
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljević N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni A-M, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu Y-J (2014). Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol  vol. 232, (5) 566-577. 10.1002/path.4327
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM and Grose RP (2014). Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion. Embo Mol Med  vol. 6, (4) 467-481. 10.1002/emmm.201302698
Fearon AE and Grose RP (2014). Grb-ing receptor activation by the tail. Nat Struct Mol Biol  vol. 21, (2) 113-114. 10.1038/nsmb.2767

2013

Fearon AE, Gould CR and Grose RP (2013). FGFR signalling in women's cancers. Int J Biochem Cell Biol  vol. 45, (12) 2832-2842. 10.1016/j.biocel.2013.09.017
Guasti L, Candy Sze WC, McKay T, Grose R and King PJ (2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Mol Cell Endocrinol  vol. 371, (1-2) 182-188. 10.1016/j.mce.2013.01.014
Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C and Salomoni P (2013). The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene  vol. 32, (6) 699-712. 10.1038/onc.2012.111
Robbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR and Grose RP (2013). Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing. Plos One  vol. 8, (11) 10.1371/journal.pone.0078839

2012

Meyer M, Müller A-K, Yang J, Moik D, Ponzio G, Ornitz DM, Grose R and Werner S (2012). FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin. J Cell Sci  vol. 125, (Pt 23) 5690-5701. 10.1242/jcs.108167
Chioni A-M and Grose R (2012). FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior. J Cell Biol  vol. 197, (6) 801-817. 10.1083/jcb.201108077
Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR, Garrod DR, Fortune F and Wan H (2012). Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol  vol. 227, (1) 81-93. 10.1002/path.3982
Jarosz M, Robbez-Masson L, Chioni A-M, Cross B, Rosewell I and Grose R (2012). Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. Plos One  vol. 7, (6) 10.1371/journal.pone.0039436

2010

Yang J, Meyer M, Müller A-K, Böhm F, Grose R, Dauwalder T, Verrey F, Kopf M, Partanen J, Bloch W, Ornitz DM and Werner S (2010). Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. J Cell Biol  vol. 188, (6) 935-952. 10.1083/jcb.200910126
Turner N and Grose R (2010). Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer  vol. 10, (2) 116-129. 10.1038/nrc2780
Chioni A-M, Shao D, Grose R and Djamgoz MBA (2010). Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration. Int J Biochem Cell Biol  vol. 42, (2) 346-358. 10.1016/j.biocel.2009.11.021
D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V and Hodivala-Dilke KM (2010). Regulation of lymphatic-blood vessel separation by endothelial Rac1 (vol 136, pg 4043, 2009). Development  vol. 137, (2) 359-359. 10.1242/dev.047597
Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F and Wan H (2010). Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. Plosone  Plos One  vol. 5, (12) 10.1371/journal.pone.0014211

2009

Chioni A-M and Grose R (2009). Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3). Eur J Cell Biol  vol. 88, (7) 371-384. 10.1016/j.ejcb.2009.01.004

2008

Chioni A-M and Grose R (2008). Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesis. Fibrogenesis Tissue Repair  vol. 1, (1) 10.1186/1755-1536-1-8

2007

Grose R, Fantl V, Werner S, Chioni A-M, Jarosz M, Rudling R, Cross B, Hart IR and Dickson C (2007). The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Embo J  vol. 26, (5) 1268-1278. 10.1038/sj.emboj.7601583

2005

Grose R and Dickson C (2005). Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev  vol. 16, (2) 179-186. 10.1016/j.cytogfr.2005.01.003
Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A and Hodivala-Dilke K (2005). Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nat Med  vol. 11, (2) 167-174. 10.1038/nm1165

2004

Grose R and Werner S (2004). Wound-healing studies in transgenic and knockout mice. Mol Biotechnol  vol. 28, (2) 147-166. 10.1385/MB:28:2:147
Zhang HB, Dessimoz J, Beyer TA, Krampert M, Williams LT, Werner S and Grose R (2004). Fibroblast growth factor receptor 1-lllb is dispensable for skin morphogenesis and wound healing. Eur J Cell Biol  vol. 83, (1) 3-11. 10.1078/0171-9335-00355
Grose R (2004). Common ground in the transcriptional profiles of wounds and tumors. Genome Biol  vol. 5, (6) 10.1186/gb-2004-5-6-228

2003

Young P, Boussadia O, Halfter H, Grose R, Berger P, Leone DP, Robenek H, Charnay P, Kemler R and Suter U (2003). E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles. Embo J  vol. 22, (21) 5723-5733. 10.1093/emboj/cdg560
Petiot A, Conti FJA, Grose R, Revest J-M, Hodivala-Dilke KM and Dickson C (2003). A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development  vol. 130, (22) 5493-5501. 10.1242/dev.00788
Grose R (2003). Epithelial migration: open your eyes to c-Jun. Curr Biol  vol. 13, (17) R678-R680. 10.1016/s0960-9822(03)00607-9
Beyer TA, Werner S, Dickson C and Grose R (2003). Fibroblast growth factor 22 and its potential role during skin development and repair. Exp Cell Res  vol. 287, (2) 228-236. 10.1016/S0014-4827(03)00139-3
Werner S and Grose R (2003). Regulation of wound healing by growth factors and cytokines. Physiol Rev  vol. 83, (3) 835-870. 10.1152/physrev.2003.83.3.835
Martin P, D'Souza D, Martin J, Grose R, Cooper L, Maki R and McKercher SR (2003). Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells. Curr Biol  vol. 13, (13) 1122-1128. 10.1016/s0960-9822(03)00396-8
Grose R and Werner S (2003). Wound Healing Studies in Transgenic and Knockout Mice. Wound Healing  Springer Nature  10.1385/1-59259-332-1:191
Grose R and Werner S (2003). Wound healing studies in transgenic and knockout mice. A review. Methods Mol Med  vol. 78, 191-216. 10.1385/1-59259-332-1:191

2002

Wood W, Jacinto A, Grose R, Woolner S, Gale J, Wilson C and Martin P (2002). Wound healing recapitulates morphogenesis in Drosophila embryos. Nat Cell Biol  vol. 4, (11) 907-912. 10.1038/ncb875
Grose R, Werner S, Kessler D, Tuckermann J, Huggel K, Durka S and Reichardt HM (2002). A role for endogenous glucocorticoids in wound repair. Embo Rep  vol. 3, (6) 575-582. 10.1093/embo-reports/kvf119
Grose R, Hutter C, Bloch W, Thorey I, Watt FM, Fässler R, Brakebusch C and Werner S (2002). A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development  vol. 129, (9) 2303-2315. 10.1242/dev.129.9.2303
Grose R and Werner S (2002). An aPPARently protective mechanism for keratinocytes in wounded skin. Trends Mol Med  vol. 8, (4) 149-151. 10.1016/s1471-4914(02)02312-2
Grose R, Harris BS, Cooper L, Topilko P and Martin P (2002). Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse. Dev Dyn  vol. 223, (3) 371-378. 10.1002/dvdy.10064

2000

Bloch W, Huggel K, Sasaki T, Grose R, Bugnon P, Addicks K, Timpl R and Werner S (2000). The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. Wiley  The Faseb Journal  vol. 14, (15) 2373-2376. 10.1096/fj.00-0490fje
Brakebusch C, Grose R, Quondamatteo F, Ramirez A, Jorcano JL, Pirro A, Svensson M, Herken R, Sasaki T, Timpl R, Werner S and Fässler R (2000). Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes. Springer Nature  The Embo Journal  vol. 19, (15) 3990-4003. 10.1093/emboj/19.15.3990

1999

Grose R and Martin P (1999). Parallels between wound repair and morphogenesis in the embryo. Elsevier  Seminars in Cell and Developmental Biology  vol. 10, (4) 395-404. 10.1006/scdb.1999.0326

Grants

Grants of specific relevance to Predictive in vitro Models
Nanoscale dissection of the Ephrin-Eph Receptor signalling axis in cellular invasion
Grose RP, Grose R and Bolton C
Biotechnology and Biological Sciences Research Council (26-09-2021 - 29-09-2025)
Summary

A confocal microscope for multidisciplinary dynamic studies of complex biological systems
Grose RP, Mullineaux CW, Baptista Ribeiro P, Brennan CH, De Mendoza A, Draviam VM, Elphick MR, Engl C, Godinho S, Grose R, Kermorgant S, Martin Duran JM, McCormick PJ, Palacios IM, Palma M, Resmini M, Ruban A, Sharp TV, Stollewerk A and Thorpe P
£390,834 Biotechnology and Biological Sciences Research Council (31-07-2022 - 30-07-2023)
Summary
Exploring the role of adenosine axis in the tumour microenvironment of pancreatic cancer
Grose RP and Tomas-Bort E
£104,971 Barts Charity (01-09-2019 - 28-02-2023)
Myoepithelial degradome in the progression of DCIS to invasive cancer
Grose RP and Carter E
£328,142 Cancer Research UK (01-02-2019 - 31-01-2023)
Myoepithelial degradome in the progression of DCIS to invasive cancer
Grose R
£149,769 Cancer Research UK (01-02-2019 - 31-01-2023)
TRACER 3D cultures to unravel the role of myoepithelial cells in breast cancer progression
Grose RP and Roozitalab R
£13,363 Natural Environment Research Council [2006-2012] (01-09-2021 - 31-08-2022)
Myoepithelial/luminal cross-talk in the progression of DCIS to invasive breast cancer
Grose RP, Rodriguez Cutillas P and Grose R
£201,816 Breast Cancer Now (01-05-2018 - 30-06-2022)