Prof Richard Grose
Professor of Cancer Cell Biology
Barts Cancer Institute
Queen Mary University of London
Queen Mary University of London
Research
Cellular crosstalk, 3D modelling, Breast Cancer, Pancreatic Cancer, Receptor tyrosine kinases, Fibroblast Growth Factors
Interests
We work with both cell line-based and primary cell-based 2D and 3D model systems, studying cellular crosstalk and tumour-stromal interactions in solid tumours - with a focus on breast and pancreatic cancer. We are particularly interested in interactions between luminal, myoepithelial and immune cells in the progression of Ductal Carcinoma in situ in the breast - including understanding how these cells interact with the surrounding stroma, with a particular focus on proteolytic activity. In pancreatic cancer, we are studying cancer-stellate cell interactions. We have expertise in studying a number of cell surface receptors and currently have projects involving FGFRs, EGFR, HER2, Cannabinoid receptors, Purinergic signalling and the Ephrin-Eph receptor axis.Publications of specific relevance to Predictive <em>in vitro</em> Models
2023
The Future of Precision OncologyRulten SL, Grose RP, Gatz SA, Jones JL and Cameron AJM
International Journal of Molecular Sciences, Mdpi vol. 24 (16)
09-08-2023
ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradationGibson SV, Madzharova E, Tan AC, Allen MD, Keller UAD, Jones JL, Carter EP and Grose RP
Matrix Biology, Elsevier vol. 121, 74-89.
17-06-2023
HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 InductionClayton NS, Carter EP, Fearon AE, Heward JA, Fernández LR, Boughetane L, Wilkes EH, Cutillas PR and Grose RP
International Journal of Molecular Sciences, Mdpi vol. 24 (7)
25-03-2023
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasionBort ET, Joseph MD, Wang Q, Carter EP, Roth NJ, Gibson J, Samadi A, Kocher HM, Simoncelli S, McCormick PJ and Grose RP
Elife, Elife vol. 12
21-03-2023
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progressionGibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A, Brisken C, Peck B, Cameron AJ, Marshall JF, Jones JL, Carter EP and Grose RP
Npj Breast Cancer, Springer Nature vol. 9 (1)
02-03-2023
Everybody needs good neighbours: the progressive DCIS microenvironmentGibson SV, Roozitalab RM, Allen MD, Jones JL, Carter EP and Grose RP
Trends in Cancer, Elsevier vol. 9 (4), 326-338.
02-02-2023
Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin openingHayat A, Carter EP, King HW, Ors A, Doe A, Teijeiro SA, Charrot S, Godinho S, Cutillas P, Mohammed H, Grose RP and Ficz G
Disease Models & Mechanisms, The Company of Biologists vol. 16 (2)
01-02-2023
In silico targeting of colony-stimulating factor-1 receptor: delineating immunotherapy in cancerAzhar Z, Grose RP, Raza A and Raza Z
Exploration of Targeted Anti-Tumor Therapy, Open Exploration Publishing vol. 4 (4), 727-742.
01-01-2023
2022
Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1Coetzee AS, Carter EP, Rodríguez-Fernández L, Heward J, Wang Q, Karim SA, Boughetane L, Milton C, Uyulur F, Morton JP, Kocher HM and Grose RP
Oncogene, Springer Nature vol. 42 (7), 491-500.
10-11-2022
Single‐cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancerYu Z, Zhang J, Zhang Q, Wei S, Shi R, Zhao R, An L, Grose R, Feng D and Wang H
Cell Proliferation, Wiley vol. 55 (6)
13-05-2022
The Obscure Potential of AHNAK2Zardab M, Stasinos K, Grose RP and Kocher HM
Cancers, Mdpi vol. 14 (3)
21-01-2022
FGF signalling facilitates cervical cancer progressionMahmood HTNA, Tomas Bort E, Walker AJ, Grose RP and Chioni AM
The Federation of European Biochemical Societies (Febs) Journal, Wiley
03-01-2022
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasionMurray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, Hodivala-Dilke K, Grose RP, Kocher HM, Gavara N, Pearce O, Cutillas P, Marshall JF and Cameron AJM
Cell Reports, Elsevier vol. 38 (4)
01-01-2022
2021
Biological Significance and Targeting of the FGFR Axis in CancerChioni A-M and Grose RP
Cancers, Mdpi vol. 13 (22)
13-11-2021
Quantitative Super-Resolution Imaging for the Analysis of GPCR OligomerizationJoseph MD, Bort ET, Grose RP, McCormick PJ and Simoncelli S
Biomolecules, Mdpi vol. 11 (10)
12-10-2021
Expression of programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand (PD-L1) in adenocarcinomas of the gastroesophageal junction change significantly after neoadjuvant treatmentJomrich G, Kollmann D, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C, Tsai Y-C, Guenova E and Schoppmann SF
European Journal of Surgical Oncology, Elsevier vol. 48 (2), 383-390.
11-08-2021
Tumour microenvironment 3D-modelling: simplicity to complexity and back againCarter EP, Roozitalab R, Gibson SV and Grose RP
Trends in Cancer, Elsevier vol. 7 (11), 1033-1046.
24-07-2021
Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapyJomrich G, Kollmann D, Wilfing L, Radosavljevic S, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C, Tsai Y-C, Guenova E and Schoppmann SF
European Surgery, Springer Nature vol. 53 (6), 287-293.
05-05-2021
Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic CancerCarter EP, Coetzee AS, Tomas Bort E, Wang Q, Kocher HM and Grose RP
Cells, Mdpi vol. 10 (4)
08-04-2021
Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruptionAdams SD, Csere J, D’angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F and Godinho SA
Current Biology, Elsevier vol. 31 (7), 1403-1416.e7.
15-02-2021
Hallmarks of cancer—the new testamentSenga SS and Grose RP
Open Biology, The Royal Society vol. 11 (1)
01-01-2021
2020
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathwayWilcz‐Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala‐Dilke K and Bianchi K
Embo Molecular Medicine, Springer Nature vol. 12 (2)
13-01-2020
2018
Emerging Roles of Fibroblast Growth Factor 10 in Cancer.Clayton NS and Grose RP
Front Genet vol. 9, 499-499.
24-10-2018
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven CancerFearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR and Grose RP
Cell Reports, Elsevier vol. 22 (9), 2469-2481.
01-02-2018
2017
Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment.Clayton NS, Wilson AS, Laurent EP, Grose RP and Carter EP
Dev Dyn vol. 246 (7), 493-501.
18-05-2017
A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancerCarter EP, Gopsill JA, Gomm JJ, Jones JL and Grose RP
Breast Cancer Research, Springer Nature vol. 19 (1)
21-04-2017
2016
3D Organotypic Culture Model to Study Components of ERK Signaling.Chioni A-M, Bajwa RT and Grose R
Methods Mol Biol, Springerlink vol. 1487, 255-267.
07-12-2016
Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinomaGROSE RP, Dawkins JBN, Wang J, maniati , heward , koniali , kocher , martin , chelala , balkwill and fitzgibbon
Cancer Research, American Association For Cancer Research
10-06-2016
Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma.Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P, Grose RP, Lemoine NR, Richards FM and Kocher HM
Journal of Pathology, Wiley vol. 239 (3), 286-296.
25-05-2016
Dysregulated FGF signalling in neoplastic disordersTanner Y and Grose RP
Seminars in Cell and Developmental Biology, Elsevier: 12 Months vol. 53, 126-135.
01-05-2016
2015
Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian CancerMilagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R, Bowtell DDL, Hochhauser D and Balkwill FR
Cancer Research, American Association For Cancer Research (Aacr) vol. 75 (7), 1255-1264.
31-03-2015
The FGFR Receptor FamilyFearon AE, Chioni A-M and Grose RP
In Receptor Tyrosine Kinases: Family and Subfamilies, Springer Nature 265-295.
01-01-2015
2014
Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunctionCarter EP, Fearon AE and Grose RP
Trends in Cell Biology, Elsevier vol. 25 (4), 221-233.
29-11-2014
The ins and outs of fibroblast growth factor receptor signalling.Coleman SJ, Bruce C, Chioni A-M, Kocher HM and Grose RP
Clin Sci (Lond) vol. 127 (4), 217-231.
01-08-2014
Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation.Coleman SJ, Watt J, Arumugam P, Solaini L, Carapuca E, Ghallab M, Grose RP and Kocher HM
World J Gastroenterol vol. 20 (26), 8471-8481.
14-07-2014
Identification of ZDHHC14 as a novel human tumour suppressor gene.Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljević N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni A-M, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu Y-J
J Pathol vol. 232 (5), 566-577.
01-04-2014
Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion.Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM and Grose RP
Embo Mol Med vol. 6 (4), 467-481.
01-04-2014
Grb-ing receptor activation by the tail.Fearon AE and Grose RP
Nat Struct Mol Biol vol. 21 (2), 113-114.
01-02-2014
2013
FGFR signalling in women's cancers.Fearon AE, Gould CR and Grose RP
Int J Biochem Cell Biol vol. 45 (12), 2832-2842.
01-12-2013
FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development.Guasti L, Candy Sze WC, McKay T, Grose R and King PJ
Mol Cell Endocrinol vol. 371 (1-2), 182-188.
22-05-2013
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells.Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C and Salomoni P
Oncogene vol. 32 (6), 699-712.
07-02-2013
Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing.Robbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR and Grose RP
Plos One vol. 8 (11)
01-01-2013
2012
FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin.Meyer M, Müller A-K, Yang J, Moik D, Ponzio G, Ornitz DM, Grose R and Werner S
J Cell Sci vol. 125 (Pt 23), 5690-5701.
01-12-2012
FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior.Chioni A-M and Grose R
J Cell Biol vol. 197 (6), 801-817.
11-06-2012
Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR, Garrod DR, Fortune F and Wan H
J Pathol vol. 227 (1), 81-93.
01-05-2012
Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.Jarosz M, Robbez-Masson L, Chioni A-M, Cross B, Rosewell I and Grose R
Plos One vol. 7 (6)
01-01-2012
2010
Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis.Yang J, Meyer M, Müller A-K, Böhm F, Grose R, Dauwalder T, Verrey F, Kopf M, Partanen J, Bloch W, Ornitz DM and Werner S
J Cell Biol vol. 188 (6), 935-952.
22-03-2010
Fibroblast growth factor signalling: from development to cancer.Turner N and Grose R
Nat Rev Cancer vol. 10 (2), 116-129.
01-02-2010
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration.Chioni A-M, Shao D, Grose R and Djamgoz MBA
Int J Biochem Cell Biol vol. 42 (2), 346-358.
01-02-2010
Regulation of lymphatic-blood vessel separation by endothelial Rac1 (vol 136, pg 4043, 2009)D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V and Hodivala-Dilke KM
Development vol. 137 (2), 359-359.
15-01-2010
Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src.Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F and Wan H
Plos One, Plosone vol. 5 (12)
01-01-2010
2009
Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3).Chioni A-M and Grose R
Eur J Cell Biol vol. 88 (7), 371-384.
01-07-2009
2008
Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesis.Chioni A-M and Grose R
Fibrogenesis Tissue Repair vol. 1 (1)
11-12-2008
2007
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.Grose R, Fantl V, Werner S, Chioni A-M, Jarosz M, Rudling R, Cross B, Hart IR and Dickson C
Embo J vol. 26 (5), 1268-1278.
07-03-2007
2005
Fibroblast growth factor signaling in tumorigenesis.Grose R and Dickson C
Cytokine Growth Factor Rev vol. 16 (2), 179-186.
01-04-2005
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A and Hodivala-Dilke K
Nat Med vol. 11 (2), 167-174.
01-02-2005
2004
Wound-healing studies in transgenic and knockout mice.Grose R and Werner S
Mol Biotechnol vol. 28 (2), 147-166.
01-10-2004
Fibroblast growth factor receptor 1-lllb is dispensable for skin morphogenesis and wound healingZhang HB, Dessimoz J, Beyer TA, Krampert M, Williams LT, Werner S and Grose R
Eur J Cell Biol vol. 83 (1), 3-11.
01-02-2004
Common ground in the transcriptional profiles of wounds and tumors.Grose R
Genome Biol vol. 5 (6)
01-01-2004
2003
E-cadherin controls adherens junctions in the epidermis and the renewal of hair folliclesYoung P, Boussadia O, Halfter H, Grose R, Berger P, Leone DP, Robenek H, Charnay P, Kemler R and Suter U
Embo J vol. 22 (21), 5723-5733.
03-11-2003
A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning.Petiot A, Conti FJA, Grose R, Revest J-M, Hodivala-Dilke KM and Dickson C
Development vol. 130 (22), 5493-5501.
01-11-2003
Fibroblast growth factor 22 and its potential role during skin development and repairBeyer TA, Werner S, Dickson C and Grose R
Exp Cell Res vol. 287 (2), 228-236.
15-07-2003
Regulation of wound healing by growth factors and cytokines.Werner S and Grose R
Physiol Rev vol. 83 (3), 835-870.
01-07-2003
Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells.Martin P, D'Souza D, Martin J, Grose R, Cooper L, Maki R and McKercher SR
Curr Biol vol. 13 (13), 1122-1128.
01-07-2003
Wound Healing Studies in Transgenic and Knockout MiceGrose R and Werner S
In Wound Healing, Springer Nature 191-216.
01-01-2003
Wound healing studies in transgenic and knockout mice. A review.Grose R and Werner S
Methods Mol Med vol. 78, 191-216.
01-01-2003
2002
Wound healing recapitulates morphogenesis in Drosophila embryosWood W, Jacinto A, Grose R, Woolner S, Gale J, Wilson C and Martin P
Nat Cell Biol vol. 4 (11), 907-912.
01-11-2002
A role for endogenous glucocorticoids in wound repair.Grose R, Werner S, Kessler D, Tuckermann J, Huggel K, Durka S and Reichardt HM
Embo Rep vol. 3 (6), 575-582.
01-06-2002
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair.Grose R, Hutter C, Bloch W, Thorey I, Watt FM, Fässler R, Brakebusch C and Werner S
Development vol. 129 (9), 2303-2315.
01-05-2002
An aPPARently protective mechanism for keratinocytes in wounded skinGrose R and Werner S
Trends Mol Med vol. 8 (4), 149-151.
01-04-2002
Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse.Grose R, Harris BS, Cooper L, Topilko P and Martin P
Dev Dyn vol. 223 (3), 371-378.
01-03-2002
2000
The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healingBloch W, Huggel K, Sasaki T, Grose R, Bugnon P, Addicks K, Timpl R and Werner S
The Faseb Journal, Wiley vol. 14 (15), 2373-2376.
06-10-2000
Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytesBrakebusch C, Grose R, Quondamatteo F, Ramirez A, Jorcano JL, Pirro A, Svensson M, Herken R, Sasaki T, Timpl R, Werner S and Fässler R
The Embo Journal, Springer Nature vol. 19 (15), 3990-4003.
01-08-2000
1999
Parallels between wound repair and morphogenesis in the embryoGrose R and Martin P
Seminars in Cell and Developmental Biology, Elsevier vol. 10 (4), 395-404.
01-08-1999
Grants
Grants of specific relevance to Predictive in vitro Models
British Council Scholarships for Women in STEM – Academic Year 2024-25Richard Grose
£180,000 British Council
01-12-2023 - 31-03-2026
Anti-Histamines as novel therapeutics in pancreatic cancerPeter McCormick and Richard Grose
£219,000 Pancreatic Cancer Research Fund
01-01-2023 - 31-12-2025
Defining the functional role of EGFR in glioblastoma tumour heterogeneityPaulo Baptista Ribeiro and Richard Grose
£185,285 Barts and the London Charity
01-10-2022 - 18-09-2027
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Jose Martin Duran, Paulo Baptista Ribeiro, Susana Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023
Deconvoluting cellular crosstalk in pancreatic cancer invasionRichard Grose
£49,511 Barts and the London Charity
01-09-2021 - 31-12-2022
TRACER 3D cultures to unravel the role of myoepithelial cells in breast cancer progressionRichard Grose
£13,363 NERC Natural Environment Research Council
01-09-2021 - 31-08-2022
Exploring the role of adenosine axis in the tumour microenvironment of pancreatic cancerRichard Grose
£107,971 Barts and the London Charity
01-09-2019 - 28-02-2023
Myoepithelial degradome in the progression of DCIS to invasiveRichard Grose
£477,911 CR-UK Cancer Research UK
01-02-2019 - 31-08-2023
Myoepithelial/luminal cross-talk in the progression of DCIS to invasive breast cancerRichard Grose
£201,816 Breast Cancer Now
01-05-2018 - 30-06-2022
Myoepithelial Dysfunction in the Progression of DCIS to invasive breast cancerRichard Grose
£10,078 Barts and the London Charity
01-09-2017 - 31-08-2018