Prof Richard Grose

BSc PhD

Professor of Cancer Cell Biology

Barts Cancer Institute
Faculty of Medicine and Dentistry, Queen Mary University of London

020 7882 3574
r.p.grose@qmul.ac.uk
www.groselab.com

Research
Publications
Grants

Research

Cellular crosstalk, 3D modelling, Breast Cancer, Pancreatic Cancer, Receptor tyrosine kinases, Fibroblast Growth Factors

Cancer Models, Skin Models

Interests

We work with both cell line-based and primary cell-based 2D and 3D model systems, studying cellular crosstalk and tumour-stromal interactions in solid tumours - with a focus on breast and pancreatic cancer. We are particularly interested in interactions between luminal, myoepithelial and immune cells in the progression of Ductal Carcinoma in situ in the breast - including understanding how these cells interact with the surrounding stroma, with a particular focus on proteolytic activity. In pancreatic cancer, we are studying cancer-stellate cell interactions. We have expertise in studying a number of cell surface receptors and currently have projects involving FGFRs, EGFR, HER2, Cannabinoid receptors, Purinergic signalling and the Ephrin-Eph receptor axis.

Publications

2021

Mahmood H-T-NA, Tomas Bort E, Walker AJ, Grose RP and Chioni A-M (2021). FGF signalling facilitates cervical cancer progression. Febs J 10.1111/febs.16331

Jomrich G, Kollmann D, Wilfing L, Radosavljevic S, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C, Tsai YC, Guenova E and Schoppmann SF (2021). Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapy. European Surgery - Acta Chirurgica Austriaca vol. 53, (6) 287-293. 10.1007/s10353-021-00700-4

Chioni AM and Grose RP (2021). Biological significance and targeting of the fgfr axis in cancer. Cancers vol. 13, (22) 10.3390/cancers13225681

Joseph MD, Bort ET, Grose RP, McCormick PJ and Simoncelli S (2021). Quantitative super‐resolution imaging for the analysis of GPCR oligomerization. Biomolecules vol. 11, (10) 10.3390/biom11101503

(2021). Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. Current Biology vol. 31, (7) 1403-1416.e7. 10.1016/j.cub.2021.01.028

Carter EP, Coetzee AS, Bort ET, Wang Q, Kocher HM and Grose RP (2021). Dissecting fgf signalling to target cellular crosstalk in pancreatic cancer. Cells vol. 10, (4) 10.3390/cells10040847

Coetzee A, Grose R and Kocher H (2021). Pancreatic Cancer Organotypic Models. 10.1007/82_2019_155

Senga SS and Grose RP (2021). Hallmarks of cancer—the new testament. Open Biology vol. 11, (1) 10.1098/rsob.200358

Carter EP, Roozitalab R, Gibson SV and Grose RP (2021). Tumour microenvironment 3D-modelling: simplicity to complexity and back again. Trends in Cancer 10.1016/j.trecan.2021.06.009

Jomrich G, Kollmann D, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C, Tsai YC, Guenova E and Schoppmann SF (2021). Expression of programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand (PD-L1) in adenocarcinomas of the gastroesophageal junction change significantly after neoadjuvant treatment. European Journal of Surgical Oncology 10.1016/j.ejso.2021.08.016

2020

Coetzee AS, Carter EP, Milton CI, Heward JA, Uluyur F, Miao J, Mardakheh FK, Wang Y, Kocher H and Grose RP (2020). Targeting FGFR signalling to disrupt cellular cross-talk in pancreatic cancer. Elsevier Pancreatology vol. 20, (8) e19-e19. 10.1016/j.pan.2020.10.014

Wilcz-Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala-Dilke K and Bianchi K (2020). Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. Embo Molecular Medicine vol. 12, (2) 10.15252/emmm.201910491

2018

Clayton NS and Grose RP (2018). Emerging Roles of Fibroblast Growth Factor 10 in Cancer. Front Genet vol. 9, 499-499. 10.3389/fgene.2018.00499

Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR and Grose RP (2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Reports vol. 22, (9) 2469-2481. 10.1016/j.celrep.2018.02.028

2017

Clayton NS, Wilson AS, Laurent EP, Grose RP and Carter EP (2017). Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment. Dev Dyn vol. 246, (7) 493-501. 10.1002/dvdy.24514

Carter EP, Gopsill JA, Gomm JJ, Jones JL and Grose RP (2017). A 3D in vitro model of the human breast duct: A method to unravel myoepithelial-luminal interactions in the progression of breast cancer. Breast Cancer Research vol. 19, (1) 10.1186/s13058-017-0843-4

2016

Chioni A-M, Bajwa RT and Grose R (2016). 3D Organotypic Culture Model to Study Components of ERK Signaling. Springerlink Methods Mol Biol vol. 1487, 255-267. 10.1007/978-1-4939-6424-6_19

GROSE RP, Dawkins JBN, Wang J, maniati , heward , koniali , kocher , martin , chelala , balkwill and fitzgibbon (2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. American Association For Cancer Research Cancer Research 10.1158/0008-5472.CAN-16-0481

Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P, Grose RP, Lemoine NR, Richards FM and Kocher HM (2016). Developing drug combinations to co-target pancreatic cancer and its supporting stroma. Pancreatology vol. 16, (3) 10.1016/j.pan.2016.04.018

Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P, Grose RP, Lemoine NR, Richards FM and Kocher HM (2016). Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma. Wiley Journal of Pathology vol. 239, (3) 286-296. 10.1002/path.4727

Tanner Y and Grose RP (2016). Dysregulated FGF signalling in neoplastic disorders. Elsevier: 12 Months Seminars in Cell and Developmental Biology vol. 53, 126-135. 10.1016/j.semcdb.2015.10.012

2015

Carter EP, Fearon AE and Grose RP (2015). Careless talk costs lives: Fibroblast growth factor receptor signalling and the consequences of pathway malfunction. Trends in Cell Biology vol. 25, (4) 221-233. 10.1016/j.tcb.2014.11.003

Milagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R, Bowtell DDL, Hochhauser D and Balkwill FR (2015). Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL6 antibodies, with implications for combined therapy in ovarian cancer. Cancer Research vol. 75, (7) 1255-1264. 10.1158/0008-5472.CAN-14-1801

Fearon AE, Chioni AM and Grose RP (2015). The FGFR receptor family. Receptor Tyrosine Kinases: Family and Subfamilies 10.1007/978-3-319-11888-8_6

2014

Coleman SJ, Bruce C, Chioni A-M, Kocher HM and Grose RP (2014). The ins and outs of fibroblast growth factor receptor signalling. Clin Sci (Lond) vol. 127, (4) 217-231. 10.1042/CS20140100

Coleman SJ, Watt J, Arumugam P, Solaini L, Carapuca E, Ghallab M, Grose RP and Kocher HM (2014). Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation. World J Gastroenterol vol. 20, (26) 8471-8481. 10.3748/wjg.v20.i26.8471

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljević N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni A-M, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu Y-J (2014). Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol vol. 232, (5) 566-577. 10.1002/path.4327

Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM and Grose RP (2014). Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion. Embo Mol Med vol. 6, (4) 467-481. 10.1002/emmm.201302698

Coleman S, Chioni A-M, Ghallab M, Anderson R, Lemoine N, Kocher H and Grose R (2014). Nuclear FGFR signalling as a driving force in pancreatic cancer. Pancreatology vol. 14, (2) 10.1016/j.pan.2014.03.014

Fearon AE and Grose RP (2014). Grb-ing receptor activation by the tail. Nat Struct Mol Biol vol. 21, (2) 113-114. 10.1038/nsmb.2767

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM, Kamam S, Chioni A-M, Gould D, Lorincz AT, Oliver T, Chelala C, Thomas GM, Mather S, Berney D, Young BD and Lu Y-J (2014). Identification of ZDHHC14 as a novel human tumour suppressor: gene. International Journal of Molecular Medicine vol. 34, S90-S90.

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni AM, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu YJ (2014). Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)). Journal of Pathology vol. 234, (1) 10.1002/path.4396

Coleman SJ, Grose RP and Kocher HM (2014). Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma. J Hepatocell Carcinoma vol. 1, 43-54. 10.2147/JHC.S48958

2013

Fearon AE, Gould CR and Grose RP (2013). FGFR signalling in women's cancers. Int J Biochem Cell Biol vol. 45, (12) 2832-2842. 10.1016/j.biocel.2013.09.017

Guasti L, Candy Sze WC, McKay T, Grose R and King PJ (2013). FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Mol Cell Endocrinol vol. 371, (1-2) 182-188. 10.1016/j.mce.2013.01.014

Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP and Kocher H (2013). 538 Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion. Gastroenterology vol. 144, (5) s-98. 10.1016/s0016-5085(13)60358-3

Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C and Salomoni P (2013). The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene vol. 32, (6) 699-712. 10.1038/onc.2012.111

Robbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR and Grose RP (2013). Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing. Plos One vol. 8, (11) 10.1371/journal.pone.0078839

Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Grose RP and Kocher HM (2013). Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells is necessary for pancreatic cancer cell invasion. Pancreatology vol. 13, (1) e10-e11. 10.1016/j.pan.2012.12.032

2012

Meyer M, Müller A-K, Yang J, Moik D, Ponzio G, Ornitz DM, Grose R and Werner S (2012). FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin. J Cell Sci vol. 125, (Pt 23) 5690-5701. 10.1242/jcs.108167

Chioni A-M and Grose R (2012). FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior. J Cell Biol vol. 197, (6) 801-817. 10.1083/jcb.201108077

(2012). Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol vol. 227, (1) 81-93. 10.1002/path.3982

Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Chaplin T, Xue L, Xu M, Foster JM, James S, Chioni AM, Jeetle S, Vasiljević NA, Marzec J, Gould D, Jones L, Lorincz AT, Oliver RTD, Mather SJ, Shipley JM, Berney DM, Young BD and Lu Y-J (2012). Abstract 4858: Identification of ZDHHC14 as a novel tumor suppressor gene commonly downregulated in human cancers. 10.1158/1538-7445.am2012-4858

Jarosz M, Robbez-Masson L, Chioni A-M, Cross B, Rosewell I and Grose R (2012). Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. Plos One vol. 7, (6) 10.1371/journal.pone.0039436

2011

Coleman SJ, Myrto-Chioni A, Grose RP and Kocher H (2011). Investigating the Role of FGF Signaling in Pancreatic Cancer. Gastroenterology vol. 140, (5) s-714. 10.1016/s0016-5085(11)62965-x

Chioni A-M, Jones LJ and Grose RP (2011). Abstract 1101: A novel role for FGFR in breast cancer. 10.1158/1538-7445.am2011-1101

2010

Yang J, Meyer M, Müller A-K, Böhm F, Grose R, Dauwalder T, Verrey F, Kopf M, Partanen J, Bloch W, Ornitz DM and Werner S (2010). Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. J Cell Biol vol. 188, (6) 935-952. 10.1083/jcb.200910126

Turner N and Grose R (2010). Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer vol. 10, (2) 116-129. 10.1038/nrc2780

Chioni A-M, Shao D, Grose R and Djamgoz MBA (2010). Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration. Int J Biochem Cell Biol vol. 42, (2) 346-358. 10.1016/j.biocel.2009.11.021

(2010). Regulation of lymphatic-blood vessel separation by endothelial Rac1 (vol 136, pg 4043, 2009). Development vol. 137, (2) 359-359. 10.1242/dev.047597

Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F and Wan H (2010). Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. Plosone Plos One vol. 5, (12) 10.1371/journal.pone.0014211

2009

(2009). Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development vol. 136, (23) 4043-4053. 10.1242/dev.035014

Chioni A-M and Grose R (2009). Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3). Eur J Cell Biol vol. 88, (7) 371-384. 10.1016/j.ejcb.2009.01.004

2008

Chioni A-M and Grose R (2008). Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesis. Fibrogenesis Tissue Repair vol. 1, (1) 10.1186/1755-1536-1-8

2007

Grose R, Fantl V, Werner S, Chioni A-M, Jarosz M, Rudling R, Cross B, Hart IR and Dickson C (2007). The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Embo J vol. 26, (5) 1268-1278. 10.1038/sj.emboj.7601583

2006

Grose R (2006). Fibroblast growth factor receptor 2-IIIb is a critical mediator of intercellular signalling in development and disease. J Invest Derm Symp P vol. 11, (1) 142-142.

2005

Grose R and Dickson C (2005). Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev vol. 16, (2) 179-186. 10.1016/j.cytogfr.2005.01.003

Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A and Hodivala-Dilke K (2005). Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nat Med vol. 11, (2) 167-174. 10.1038/nm1165

2004

Grose R and Werner S (2004). Wound-healing studies in transgenic and knockout mice. Mol Biotechnol vol. 28, (2) 147-166. 10.1385/MB:28:2:147

Zhang HB, Dessimoz J, Beyer TA, Krampert M, Williams LT, Werner S and Grose R (2004). Fibroblast growth factor receptor 1-lllb is dispensable for skin morphogenesis and wound healing. Eur J Cell Biol vol. 83, (1) 3-11. 10.1078/0171-9335-00355

Grose R (2004). Common ground in the transcriptional profiles of wounds and tumors. Genome Biol vol. 5, (6) 10.1186/gb-2004-5-6-228

2003

Young P, Boussadia O, Halfter H, Grose R, Berger P, Leone DP, Robenek H, Charnay P, Kemler R and Suter U (2003). E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles. Embo J vol. 22, (21) 5723-5733. 10.1093/emboj/cdg560

Petiot A, Conti FJA, Grose R, Revest J-M, Hodivala-Dilke KM and Dickson C (2003). A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development vol. 130, (22) 5493-5501. 10.1242/dev.00788

Grose R (2003). Epithelial migration: open your eyes to c-Jun. Curr Biol vol. 13, (17) R678-R680. 10.1016/s0960-9822(03)00607-9

Beyer TA, Werner S, Dickson C and Grose R (2003). Fibroblast growth factor 22 and its potential role during skin development and repair. Exp Cell Res vol. 287, (2) 228-236. 10.1016/S0014-4827(03)00139-3

Werner S and Grose R (2003). Regulation of wound healing by growth factors and cytokines. Physiol Rev vol. 83, (3) 835-870. 10.1152/physrev.2003.83.3.835

(2003). Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells. Curr Biol vol. 13, (13) 1122-1128. 10.1016/s0960-9822(03)00396-8

Grose R and Werner S (2003). Wound Healing Studies in Transgenic and Knockout Mice. Wound Healing 10.1385/1-59259-332-1:191

Grose R and Werner S (2003). Wound healing studies in transgenic and knockout mice. A review. Methods Mol Med vol. 78, 191-216. 10.1385/1-59259-332-1:191

2002

Wood W, Jacinto A, Grose R, Woolner S, Gale J, Wilson C and Martin P (2002). Wound healing recapitulates morphogenesis in Drosophila embryos. Nat Cell Biol vol. 4, (11) 907-912. 10.1038/ncb875

Grose R, Werner S, Kessler D, Tuckermann J, Huggel K, Durka S and Reichardt HM (2002). A role for endogenous glucocorticoids in wound repair. Embo Rep vol. 3, (6) 575-582. 10.1093/embo-reports/kvf119

Grose R, Hutter C, Bloch W, Thorey I, Watt FM, Fässler R, Brakebusch C and Werner S (2002). A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development vol. 129, (9) 2303-2315. 10.1242/dev.129.9.2303

Grose R and Werner S (2002). An aPPARently protective mechanism for keratinocytes in wounded skin. Trends Mol Med vol. 8, (4) 149-151. 10.1016/s1471-4914(02)02312-2

Grose R, Harris BS, Cooper L, Topilko P and Martin P (2002). Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse. Dev Dyn vol. 223, (3) 371-378. 10.1002/dvdy.10064

2000

Brakebusch C, Grose R, Quondamatteo F, Ramirez A, Jorcano JL, Pirro A, Svensson M, Herken R, Sasaki T, Timpl R, Werner S and Fässler R (2000). Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes. Embo Journal vol. 19, (15) 3990-4003. 10.1093/emboj/19.15.3990

Bloch W, Huggel K, Sasaki T, Grose R, Bugnon P, Addicks K, Timpl R and Werner S (2000). The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. The Faseb Journal : Official Publication of The Federation of American Societies For Experimental Biology vol. 14, (15) 2373-2376. 10.1096/fj.00-0490fje

1999

Grose R and Martin P (1999). Parallels between wound repair and morphogenesis in the embryo. Seminars in Cell and Developmental Biology vol. 10, (4) 395-404. 10.1006/scdb.1999.0326

Grants

Exploring the role of adenosine axis in the tumour microenvironment of pancreatic cancer
Grose RP, Tomas-Bort E and McCormick PJ
£104,971 Barts Charity (01-09-2019 - 28-02-2023)

Myoepithelial degradome in the progression of DCIS to invasive cancer
Grose RP and Carter E
£328,142 Cancer Research UK (01-02-2019 - 31-01-2023)

Myoepithelial degradome in the progression of DCIS to invasive cancer
Grose R
£149,769 Cancer Research UK (01-02-2019 - 31-01-2023)

TRACER 3D cultures to unravel the role of myoepithelial cells in breast cancer progression
Grose RP and Roozitalab R
£13,363 Natural Environment Research Council [2006-2012] (01-09-2021 - 31-08-2022)

Myoepithelial/luminal cross-talk in the progression of DCIS to invasive breast cancer
Rodriguez Cutillas P, Grose R and Carter EP
£201,816 Breast Cancer Now (01-05-2018 - 30-06-2022)